Jon Violin

Affiliations: 
1997-2003 UCSD School of Medicine, San Diego, CA, United States 
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"Jon Violin"

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Alexandra C. Newton grad student 1997-2003 UCSD (Chemistry Tree)
 (Spatiotemporal dynamics of protein kinase C signaling.)
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Publications

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Moye LS, Tipton AF, Dripps I, et al. (2018) Delta opioid receptor agonists are effective for multiple types of headache disorders. Neuropharmacology
Koblish M, Carr R, Siuda ER, et al. (2017) TRV0109101, a G Protein-Biased Agonist of the -Opioid Receptor, Does Not Promote Opioid-Induced Mechanical Allodynia following Chronic Administration. The Journal of Pharmacology and Experimental Therapeutics. 362: 254-262
Wobblish M, Carr R, Cowan C, et al. (2017) (224) Assessment of Nociceptive Sensitization with TRV9101, a Novel μ Receptor G Protein Pathway Selective Modulator (μ-GPS), versus Fentanyl, Morphine, and Oxycodone The Journal of Pain. 18: S32
Siuda ER, Carr R, Rominger DH, et al. (2016) Biased mu-opioid receptor ligands: a promising new generation of pain therapeutics. Current Opinion in Pharmacology. 32: 77-84
Tarigopula M, Davis RT, Mungai PT, et al. (2015) Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model. Cardiovascular Research. 107: 226-34
Felker GM, Butler J, Collins SP, et al. (2015) Heart failure therapeutics on the basis of a biased ligand of the angiotensin-2 type 1 receptor. Rationale and design of the BLAST-AHF study (Biased Ligand of the Angiotensin Receptor Study in Acute Heart Failure). Jacc. Heart Failure. 3: 193-201
Soergel DG, Subach RA, Burnham N, et al. (2014) Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers. Pain. 155: 1829-35
Violin JD, Crombie AL, Soergel DG, et al. (2014) Biased ligands at G-protein-coupled receptors: Promise and progress Trends in Pharmacological Sciences. 35: 308-316
Rominger DH, Cowan CL, Gowen-MacDonald W, et al. (2014) Biased ligands: pathway validation for novel GPCR therapeutics. Current Opinion in Pharmacology. 16: 108-15
Strachan RT, Sun JP, Rominger DH, et al. (2014) Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR). The Journal of Biological Chemistry. 289: 14211-24
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