Parents
Sign in to add mentor| Alexandra C. Newton | grad student | 2003-2009 | UCSD (Chemistry Tree) | |
| (Mechanisms that regulate the maturation and down-regulation of protein kinase C.) | ||||
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Publications
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| Baffi TR, Lordén G, Wozniak JM, et al. (2021) mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif. Science Signaling. 14 |
| Gould CM, Antal CE, Reyes G, et al. (2011) Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form Journal of Biological Chemistry. 286: 28922-28930 |
| Hoshi N, Langeberg LK, Gould CM, et al. (2010) Interaction with AKAP79 modifies the cellular pharmacology of PKC. Molecular Cell. 37: 541-50 |
| Gould CM, Kannan N, Taylor SS, et al. (2009) The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. The Journal of Biological Chemistry. 284: 4921-35 |
| Gould CM, Newton AC. (2008) The life and death of protein kinase C Current Drug Targets. 9: 614-625 |
| Facchinetti V, Ouyang W, Wei H, et al. (2008) The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. The Embo Journal. 27: 1932-43 |
| Chen D, Gould C, Garza R, et al. (2007) Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. The Journal of Biological Chemistry. 282: 33776-87 |
| Gould C, Wong CF. (2002) Designing specific protein kinase inhibitors: insights from computer simulations and comparative sequence/structure analysis. Pharmacology & Therapeutics. 93: 169-78 |