Kathryn R. Singleton
Affiliations: | 2009-2013 | Craniofacial Biology | University of Colorado Anschutz Medical Campus, Denver, Aurora, CO |
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"Kathryn Singleton"
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| Lin KH, Rutter JC, Xie A, et al. (2020) Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer. Nature Genetics |
| Hinz TK, Kleczko EK, Singleton KR, et al. (2019) Functional RNAi Screens Define Distinct Protein Kinase Vulnerabilities in EGFR-Dependent HNSCC Cell Lines. Molecular Pharmacology |
| Pilling AB, Kim J, Estrada-Bernal A, et al. (2018) ALK is a critical regulator of the MYC-signaling axis in ALK positive lung cancer. Oncotarget. 9: 8823-8835 |
| Singleton KR, Crawford L, Tsui E, et al. (2017) Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence. Cell Reports. 21: 2796-2812 |
| Singleton KR, Earley KT, Heasley LE. (2017) Analysis of Drug Resistance Using Kinome-Wide Functional Screens. Methods in Molecular Biology (Clifton, N.J.). 1636: 163-177 |
| Singleton KR, Wood KC. (2016) Narrowing the focus: a toolkit to systematically connect oncogenic signaling pathways with cancer phenotypes. Genes & Cancer. 7: 218-228 |
| Singleton KR, Hinz TK, Kleczko EK, et al. (2015) Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC. Cancer Research. 75: 4398-406 |
| Kleczko EK, Kim J, Keysar SB, et al. (2015) An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases. Plos One. 10: e0123600 |
| Martz CA, Ottina KA, Singleton KR, et al. (2014) Systematic identification of signaling pathways with potential to confer anticancer drug resistance. Science Signaling. 7: ra121 |
| Kim J, Vasu VT, Mishra R, et al. (2014) Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy. Bioinformatics (Oxford, England). 30: 2393-8 |