William Skach, MD PhD
Affiliations: | Oregon Health and Science University, Portland, OR |
Area:
oncology, cell biologyGoogle:
"William Skach"Bio:
Medicine residency, Chief Residency, and Oncology fellowship at UCSF; Post-doctoral training with Vishwanath R. Lingappa at UCSF; Faculty position at OHSU
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Publications
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| Clancy JP, Cotton CU, Donaldson SH, et al. (2018) CFTR modulator theratyping: Current status, gaps and future directions. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society |
| Patterson MA, Bandyopadhyay A, Devaraneni PK, et al. (2015) The Ribosome-Sec61 Translocon Complex Forms a Cytosolically Restricted Environment for Early Polytopic Membrane Protein Folding. The Journal of Biological Chemistry |
| Conti BJ, Devaraneni PK, Yang Z, et al. (2015) Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation events. Molecular Cell. 58: 269-83 |
| Conti BJ, Elferich J, Yang Z, et al. (2014) Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex. Nature Structural & Molecular Biology. 21: 228-35 |
| Liu X, O'Donnell N, Landstrom A, et al. (2012) Thermal instability of ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) channel function: protection by single suppressor mutations and inhibiting channel activity. Biochemistry. 51: 5113-24 |
| Richards R, Scholz I, Powers C, et al. (2011) The cytoplasmic domain of rhesus cytomegalovirus Rh178 interrupts translation of major histocompatibility class I leader peptide-containing proteins prior to translocation. Journal of Virology. 85: 8766-76 |
| Matsumura Y, Rooney L, Skach WR. (2011) In vitro methods for CFTR biogenesis. Methods in Molecular Biology (Clifton, N.J.). 741: 233-53 |
| Skach WR. (2009) Cellular mechanisms of membrane protein folding. Nature Structural & Molecular Biology. 16: 606-12 |
| Pitonzo D, Yang Z, Matsumura Y, et al. (2009) Sequence-specific retention and regulated integration of a nascent membrane protein by the endoplasmic reticulum Sec61 translocon. Molecular Biology of the Cell. 20: 685-98 |
| Daniel CJ, Conti B, Johnson AE, et al. (2008) Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosome. The Journal of Biological Chemistry. 283: 20864-73 |