Kun-Liang Guan, PhD
|Pharmacology, Member, Moores Cancer Center||University of California, San Diego, La Jolla, CA|
Area:Molecular Biology, Cell Biology, Genetics & Genealogy
In 1963, Guan was born in Tongxiang (Jiaxing, Zhejiang Province), China. In 1982, Guan graduated (B.S.) from the Department of Biology, Hangzhou University (previous and current Zhejiang University). He did his postgraduate study at Purdue University (Ph.D. 1989; Advisor: Prof. Henry Weiner). In 1992, Guan joined the faculty in the University of Michigan (UM) Department of Biological Chemistry. From 1996 to 2000, he was an associate professor at UM. In 2000 Guan became a professor (Halvor Christensen Collegiate Professor in Life Sciences, 2003–2007) at UM.
In 1998, Kun-Liang Guan was rewarded a MacArthur Fellowship, with a grant of $230,000 over five years. Before this, he won the Schering-Plough Award, by the American Society for Biochemistry and Molecular Biology (ASBMB).
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|Tang TT, Konradi AW, Feng Y, et al. (2021) Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Molecular Cancer Therapeutics|
|You Z, Saims D, Chen S, et al. (2021) Correction: Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis. The Journal of Cell Biology. 220|
|Ma S, Wu Z, Yang F, et al. (2021) Hippo signalling maintains ER expression and ER breast cancer growth. Nature. 591: E1-E10|
|Yang H, Yu Z, Chen X, et al. (2021) Structural insights into TSC complex assembly and GAP activity on Rheb. Nature Communications. 12: 339|
|Xia YK, Zeng YR, Zhang ML, et al. (2020) Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network. Protein & Cell|
|Cheng ZL, Zhang ML, Lin HP, et al. (2020) The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming. Cell Reports. 32: 107877|
|Li J, Chen X, Ding X, et al. (2020) LATS2 Suppresses Oncogenic Wnt Signaling by Disrupting β-Catenin/BCL9 Interaction. Cell Reports. 31: 107792|
|Li X, Wang TX, Huang X, et al. (2020) Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity. Liver International : Official Journal of the International Association For the Study of the Liver|
|Zhong Y, Zhou X, Guan K, et al. (2020) Constitutively Active Rheb Regulates Nuclear mTORC1 Activity and Function The Faseb Journal. 34: 1-1|
|Koo JH, Plouffe SW, Meng Z, et al. (2019) Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth. Genes & Development|