Sarah E McClelland
Affiliations: | Barts Cancer Institute |
Area:
Chromosome segregation, chromosomal instability, cancer cell biology, replication stress, aneuploidyGoogle:
"Sarah McClelland"Parents
Sign in to add mentor| mark szczelkun | grad student | 1999-2003 | University of Bristol |
| Andrew D. McAinsh | post-doc | (Chemistry Tree) | |
| Charles Swanton | post-doc | Francis Crick Institute |
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Publications
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| Lu WT, Zalmas LP, Bailey C, et al. (2024) TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling. Nature Cell Biology |
| Guscott MA, McClelland SE. (2024) Experimental evolution of cancer chromosomal changes. Nature Genetics. 56: 743-745 |
| Andrade JR, Gallagher AD, Maharaj J, et al. (2023) Disentangling the roles of aneuploidy, chromosomal instability and tumour heterogeneity in developing resistance to cancer therapies. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 31: 28 |
| Tovini L, Johnson SC, Guscott MA, et al. (2023) Targeted assembly of ectopic kinetochores to induce chromosome-specific segmental aneuploidies. The Embo Journal. e111587 |
| Guscott M, Saha A, Maharaj J, et al. (2022) The multifaceted role of micronuclei in tumour progression: A whole organism perspective. The International Journal of Biochemistry & Cell Biology. 152: 106300 |
| MacDonald C, McClelland SE. (2021) Chromosome Instability through the Ages: Parallels between Speciation and Somatic (Cancer) Evolution. Trends in Genetics : Tig |
| Tamura N, Shaikh N, Muliaditan D, et al. (2020) Specific mechanisms of chromosomal instability indicate therapeutic sensitivities in high-grade serous ovarian carcinoma. Cancer Research |
| Tovini L, McClelland SE. (2020) Towards restoring proper chromosome segregation and preventing ageing. Embo Reports. 21: e50322 |
| Dumont M, Gamba R, Gestraud P, et al. (2019) Human chromosome-specific aneuploidy is influenced by DNA-dependent centromeric features. The Embo Journal. e102924 |
| Johnson SC, McClelland SE. (2019) Watching cancer cells evolve through chromosomal instability. Nature. 570: 166-167 |