Peter J. Ratcliffe
Affiliations: | University of Oxford, Oxford, United Kingdom |
Area:
hypoxia biologyWebsite:
https://www.magd.ox.ac.uk/member-of-staff/peter-ratcliffe/Google:
"Sir Peter J. Ratcliffe"Bio:
The Nobel Prize in Physiology or Medicine 2019 was awarded jointly to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza "for their discoveries of how cells sense and adapt to oxygen availability"
DOI: 10.1073/pnas.1617222113
https://www.cam.ac.uk/research/news/cambridge-alumnus-sir-peter-ratcliffe-awarded-2019-nobel-prize-in-physiology-or-medicine
Cross-listing: Chemistry Tree
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Publications
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| Tian YM, Holdship P, To TQ, et al. (2023) Comparative analysis of N-terminal cysteine dioxygenation and prolyl-hydroxylation as oxygen-sensing pathways in mammalian cells. The Journal of Biological Chemistry. 299: 105156 |
| Lafleur VN, Halim S, Choudhry H, et al. (2023) Multi-level interaction between HIF and AHR transcriptional pathways in kidney carcinoma. Life Science Alliance. 6 |
| Lombardi O, Li R, Halim S, et al. (2022) Pan-cancer analysis of tissue and single-cell HIF-pathway activation using a conserved gene signature. Cell Reports. 41: 111652 |
| Williams CS, Rathmell WK, Carethers JM, et al. (2022) A global view of the aspiring physician-scientist. Elife. 11 |
| Sugimoto Y, Ratcliffe PJ. (2022) Isoform-resolved mRNA profiling of ribosome load defines interplay of HIF and mTOR dysregulation in kidney cancer. Nature Structural & Molecular Biology. 29: 871-880 |
| Cockman ME, Sugimoto Y, Pegg HB, et al. (2022) Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6. Proceedings of the National Academy of Sciences of the United States of America. 119: e2201483119 |
| Mirchandani AS, Jenkins SJ, Bain CC, et al. (2022) Author Correction: Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation. Nature Immunology |
| Mirchandani AS, Jenkins SJ, Bain CC, et al. (2022) Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation. Nature Immunology |
| Leissing TM, Hardy AP, Chan H, et al. (2022) Factor inhibiting HIF can catalyse two asparaginyl-hydroxylations in VNVN motifs of ankyrin fold proteins. The Journal of Biological Chemistry. 102020 |
| Frise MC, Holdsworth DA, Johnson AW, et al. (2022) Publisher Correction: Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation. Scientific Reports. 12: 3685 |