Sima Lev

Weizmann Institute of Science, Rehovot, Israel 
Cell signaling, Membrane trafficking, Cancer biology
"Sima Lev"
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Verma N, Müller AK, Kothari C, et al. (2020) Correction: Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis. Cancer Research. 80: 362
Kedan A, Verma N, Saroha A, et al. (2018) PYK2 negatively regulates the Hippo pathway in TNBC by stabilizing TAZ protein. Cell Death & Disease. 9: 985
Shin SY, Müller AK, Verma N, et al. (2018) Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for triple-negative breast cancer. Plos Computational Biology. 14: e1006192
Panayotopoulou EG, Müller AK, Börries M, et al. (2017) Targeting of apoptotic pathways by SMAC or BH3 mimetics distinctly sensitizes paclitaxel-resistant triple negative breast cancer cells. Oncotarget
Yu J, Lei R, Zhuang X, et al. (2016) MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells. Nature Communications. 7: 13884
Verma N, Müller AK, Kothari C, et al. (2016) Targeting of PYK2 synergizes with EGFR antagonists in basal-like TNBC and circumvents HER3-associated resistance via the NEDD4-NDRG1 axis. Cancer Research
Selitrennik M, Lev S. (2016) The role of phosphatidylinositol-transfer proteins at membrane contact sites. Biochemical Society Transactions. 44: 419-24
Selitrennik M, Lev S. (2015) PYK2 integrates growth factor and cytokine receptors signaling and potentiates breast cancer invasion via a positive feedback loop. Oncotarget. 6: 22214-26
Verma N, Keinan O, Selitrennik M, et al. (2015) PYK2 sustains endosomal-derived receptor signalling and enhances epithelial-to-mesenchymal transition. Nature Communications. 6: 6064
Keinan O, Kedan A, Gavert N, et al. (2014) The lipid-transfer protein Nir2 enhances epithelial-mesenchymal transition and facilitates breast cancer metastasis. Journal of Cell Science. 127: 4740-9
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