Umut Sahin, PhD

Molecular Biology and Genetics Bogazici University, Istanbul, Turkey 
PML, SUMO, Ubiquitin, Degradation, Targeted Therapies
"Umut Sahin"
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Auvin S, Öztürk H, Abaci YT, et al. (2019) A molecule inducing androgen receptor degradation and selectively targeting prostate cancer cells. Life Science Alliance. 2
Maretzky T, Swendeman S, Mogollon E, et al. (2017) Characterization of the Catalytic Properties of the Membrane-anchored Metalloprotease ADAM9 in Cell-based assays. The Biochemical Journal
Sahin U, Jollivet F, Berthier C, et al. (2016) Detection of Protein SUMOylation In Situ by Proximity Ligation Assays. Methods in Molecular Biology (Clifton, N.J.). 1475: 139-50
El Hajj H, Dassouki Z, Berthier C, et al. (2015) Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells. Blood. 125: 3447-54
Dassouki Z, Sahin U, El Hajj H, et al. (2015) ATL response to arsenic/interferon therapy is triggered by SUMO/PML/RNF4-dependent Tax degradation. Blood. 125: 474-82
Sahin U, de Thé H, Lallemand-Breitenbach V. (2014) PML nuclear bodies: assembly and oxidative stress-sensitive sumoylation. Nucleus (Austin, Tex.). 5: 499-507
Sahin U, Lallemand-Breitenbach V, de Thé H. (2014) PML nuclear bodies: regulation, function and therapeutic perspectives. The Journal of Pathology. 234: 289-91
Sahin U, Lapaquette P, Andrieux A, et al. (2014) Sumoylation of human argonaute 2 at lysine-402 regulates its stability. Plos One. 9: e102957
Sahin U, Ferhi O, Carnec X, et al. (2014) Interferon controls SUMO availability via the Lin28 and let-7 axis to impede virus replication. Nature Communications. 5: 4187
Sahin U, Ferhi O, Jeanne M, et al. (2014) Oxidative stress-induced assembly of PML nuclear bodies controls sumoylation of partner proteins. The Journal of Cell Biology. 204: 931-45
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