Robert J. Lefkowitz

Affiliations: 
Duke University, Durham, NC 
Area:
G protein-coupled receptors
Website:
http://cardiology.medicine.duke.edu/faculty/details/0096962
Google:
"Robert Lefkowitz"
Bio:

The Nobel Prize in Chemistry 2012 was awarded jointly to Robert J. Lefkowitz and Brian K. Kobilka "for studies of G-protein-coupled receptors."

Cross-listing: Neurotree - Chemistry Tree

Parents

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Ira Pastan post-doc 1968-1970 NIH (Neurotree)
Jesse Roth post-doc 1968-1970 NIH (Neurotree)
Edgar Haber post-doc 1970-1973 Harvard Medical School (Neurotree)

Children

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Jeffery Benovic grad student Duke (Neurotree)
Tom Cahill grad student Duke (Neurotree)
Henrik G. Dohlman grad student Duke University / HHMI (Physics Tree)
Anthony Nguyen grad student Duke (Neurotree)
Robert W. Walters grad student Duke (Neurotree)
Seungkirl Ahn grad student 2002 Duke (Neurotree)
Alberuni M. Zamah grad student 2002 Duke (Neurotree)
Christopher D Nelson grad student 2002-2007 Duke (Neurotree)
Kelly N. Nobles grad student 2010 Duke (Neurotree)
Minjung Choi grad student 2012-2018 Duke (Neurotree)
Shahab Akhter post-doc Duke (Neurotree)
R. Wayne Alexander post-doc Duke (Neurotree)
Lee Allen post-doc Duke (Neurotree)
Jeffrey Arriza post-doc Duke (Neurotree)
Haavard Attramadal post-doc Duke (Neurotree)
William G. Barnes post-doc Duke (Neurotree)
Jeffrey L. Benovic post-doc Duke
Tim Van Biesen post-doc Duke (Neurotree)
Nanette H. Bishopric post-doc Duke
Jeremy T. Blitzer post-doc Duke (FlyTree)
Mark Bolanowski post-doc Duke (Neurotree)
Erin Bressler post-doc Duke (Neurotree)
Margaret Briggs-Gowan post-doc Duke (Neurotree)
Ernst Burgisser post-doc Duke (Neurotree)
Sheng Cai post-doc Duke (Neurotree)
Paul G. Campbell post-doc Duke (Literature Tree)
Mei Wang Casey post-doc Duke (Neurotree)
Arnab K. Chatterjee post-doc Duke (Chemistry Tree)
Minyong Chen post-doc Duke (Chemistry Tree)
Jing Ruth Chen post-doc Duke (Neurotree)
Wei Chen post-doc Duke (Physics Tree)
Yishan Cheng post-doc Duke (Neurotree)
Minjung Choi post-doc Duke (Neurotree)
Audrey Claing post-doc Duke (Neurotree)
William T. Clarke post-doc Duke (Neurotree)
Benjamin T. Cocanougher post-doc Duke University / HHMI (Chemistry Tree)
Sheila Collins post-doc Duke (Neurotree)
Mei Cong post-doc Duke (Neurotree)
Susanna Cotecchia post-doc Duke (Neurotree)
Yehia Daaka post-doc Duke University School of Medicine (Chemistry Tree)
Laura Davidson post-doc Duke (Neurotree)
Albert S. Davies post-doc Duke (MathTree)
Andre DeLean post-doc Duke (Neurotree)
Scott M. DeWire post-doc Duke (Microtree)
Kenneth Dickinson post-doc Duke (Neurotree)
Matthew T. Drake post-doc Duke (Chemistry Tree)
Mark Drazner post-doc Duke (Neurotree)
David M. Feldman post-doc Duke (Neurotree)
Mark Fereshteh post-doc Duke (Neurotree)
Michael E. Field post-doc Duke (Neurotree)
Zoey Fredericks post-doc Duke (Neurotree)
Neil Freedman post-doc Duke (Neurotree)
Jennifer Freedman post-doc Duke (Neurotree)
Tom Frielle post-doc Duke (Neurotree)
Tiffany Garrison post-doc Duke (Neurotree)
Diane GetsyPalmer post-doc Duke (Neurotree)
Larry Goldstein post-doc Duke (FlyTree)
Thomas Gore post-doc Duke (Neurotree)
Emily M. Harris post-doc Duke (Neurotree)
William Hausdorff post-doc Duke (Neurotree)
Brian Hawes post-doc Duke (Neurotree)
James Heinsimer post-doc Duke (Neurotree)
Mark Hnatowich post-doc Duke (Neurotree)
Brian Jeffrey Hoffman post-doc Duke (Chemistry Tree)
Dan Houtz post-doc Duke (Neurotree)
Liaoyuan Hu post-doc Duke (Neurotree)
Liyin Huang post-doc Duke (Neurotree)
Guido Iaccarino post-doc Duke (Neurotree)
Christopher D. Ingersoll post-doc Duke (Biomechanics Tree)
Richard Kent post-doc Duke (Biomechanics Tree)
Khuda Dad Khan post-doc Duke (Neurotree)
Klim King post-doc Duke (Neurotree)
Michael Kjelsberg post-doc Duke (Neurotree)
Andrew Kleist post-doc Duke (Neurotree)
Bjoern Klink post-doc Duke (Neurotree)
Walter Koch post-doc Duke (Neurotree)
Trudy Kohout post-doc Duke (Neurotree)
Jeffrey J. Kovacs post-doc Duke (Neurotree)
Kathleen Krueger post-doc Duke (SocTree)
Hitoshi Kurose post-doc Duke (Neurotree)
Madan Kwatra post-doc Duke (Neurotree)
Richard Lebovitz post-doc Duke (Neurotree)
L. M. Fredrik Leeb-Lundberg post-doc Duke (Chemistry Tree)
Stephen B. Liggett post-doc Duke
Fannie Lin post-doc Duke (Neurotree)
Yuan Lin post-doc Duke (Physics Tree)
Mathew Lo post-doc Duke (Neurotree)
Jon Lomasney post-doc Duke (Neurotree)
Wulfing Lorenz post-doc Duke (Neurotree)
Louis Luttrell post-doc Duke
Sandy Macrae post-doc Duke (Neurotree)
Negin P. Martin post-doc Duke (Chemistry Tree)
Ali Masoudi post-doc Duke (Physics Tree)
Ali Masoudi post-doc Duke Medical School (Neurotree)
Hiroyaki Matsui post-doc Duke (Neurotree)
Stuart Maudsley post-doc Duke (Neurotree)
Federico Mayor post-doc Duke (Neurotree)
Patsy McDonald post-doc Duke (Neurotree)
Thomas Michel post-doc Duke (Neurotree)
John Mickey post-doc Duke (Neurotree)
Carmelo Milano post-doc Duke (Neurotree)
William E. Miller post-doc Duke (Neurotree)
Debra Mullikin-Kilpatrick post-doc Duke (Neurotree)
Hiroyasu Nakata post-doc Duke (Neurotree)
Ponnal Nambi post-doc Duke (Neurotree)
Canan Nebigil post-doc Duke (Neurotree)
Chris Nelson post-doc Duke (Neurotree)
Brian F. O'Dowd post-doc Duke (Neurotree)
Lina M. Obeid post-doc Duke (MathTree)
James Onorato post-doc Duke (Neurotree)
Martin Opperman post-doc Duke (Neurotree)
Natalia Pakharukova post-doc Duke (Neurotree)
Biswaranjan Pani post-doc Duke (Neurotree)
Gang Pei post-doc Duke (Neurotree)
Karsten Peppel post-doc Duke (Neurotree)
Steve Perry post-doc Duke (Chemistry Tree)
Kristen J. Pierce post-doc Duke (ID Tree)
Linda J. Pike post-doc Duke (Chemistry Tree)
Julie Pitcher post-doc Duke (Neurotree)
Steve Plonk post-doc Duke (Neurotree)
Tom Povsic post-doc Duke (Neurotree)
Nadeem Rahman post-doc Duke (Neurotree)
Michael Raisch post-doc Duke (Neurotree)
Keshava Rajagopal post-doc Duke
Sudar Rajagopal post-doc Duke (Neurotree)
John C. Raymond post-doc Duke (Physics Tree)
John W. Regan post-doc Duke (Neurotree)
Rosana Reis post-doc Duke (Neurotree)
Eric Reiter post-doc Duke (Neurotree)
Xiu-Rong Ren post-doc Duke (Neurotree)
Greg Della Rocca post-doc Duke (Neurotree)
Neil Roth post-doc Duke (Neurotree)
Greg Sabo post-doc Duke (Neurotree)
Philippe Samama post-doc Duke (Neurotree)
Mika Scheinin post-doc Duke (Neurotree)
Douglas Schocken post-doc Duke (Neurotree)
Debra A. Schwinn post-doc Duke (Neurotree)
Sudha K. Shenoy post-doc Duke (Neurotree)
Robert Shorr post-doc Duke (Neurotree)
Arun K. Shukla post-doc Duke (Neurotree)
Robert F. Spurney post-doc Duke (Neurotree)
Dean Staus post-doc Duke (Neurotree)
Gary L. Stiles post-doc Duke (Neurotree)
Robert Stoffel post-doc Duke (Neurotree)
Carl Stone post-doc Duke (Neurotree)
Ryan Strachan post-doc Duke (Neurotree)
Cathy Strader post-doc Duke (Neurotree)
Ruth Strasser post-doc Duke (Neurotree)
Daniel Stroik post-doc Duke (Neurotree)
Berta Strulovici post-doc Duke (Neurotree)
Jinpeng Sun post-doc Duke (Neurotree)
Robert L. Tate post-doc Duke (Microtree)
Blossom Tewelde post-doc Duke (Neurotree)
Michael Tharp post-doc Duke (Neurotree)
Alex Thomsen post-doc Duke (Neurotree)
Akira Tohgo post-doc Duke (Neurotree)
Kazushige Touhara post-doc Duke (Neurotree)
Bie Shung Tsai post-doc Duke (Neurotree)
Vivek Upadhyay post-doc Duke (Neurotree)
Ron D. Vale post-doc Duke
Johnathan Violin post-doc Duke (Neurotree)
Huijun Wei post-doc Duke (Chemistry Tree)
Michael Wessels post-doc Duke (Neurotree)
Erin J. Whalen post-doc Duke (Neurotree)
Jarl Wikberg post-doc Duke (Neurotree)
R. Sanders Williams post-doc Duke (Neurotree)
Lewis T. Williams post-doc Duke (Neurotree)
Laura M. Wingler post-doc Duke (Chemistry Tree)
Dennis Scott Witherow post-doc Duke
Kevin Xiao post-doc Duke (Neurotree)
Helen Yao post-doc Duke (Neurotree)
Takaaki Yoshimasa post-doc Duke (Neurotree)
Musa Zamah post-doc Duke (Neurotree)
Yunxiang Zang post-doc Duke (Neurotree)
Dave Zidar post-doc Duke (Neurotree)
Marc Caron post-doc 1973-1976 Duke
Lee Limbird post-doc 1973-1978 Duke (Neurotree)
Warren J. Strittmatter post-doc 1978-1978 Duke (Neurotree)
Richard A. Cerione post-doc 1982-1985 Duke University / HHMI (Chemistry Tree)
David R. Sibley post-doc 1983-1987 Duke (Neurotree)
Brian K. Kobilka post-doc 1984-1989 Duke (Chemistry Tree)
Michel Bouvier post-doc 1985-1989 Université de Montréal (Neurotree)
James Inglese post-doc 1989-1994 Duke (Neurotree)
Richard T Premont post-doc 1992-1997 Duke University School of Medicine (Chemistry Tree)
Randy A. Hall post-doc 1996-1999 Duke (Neurotree)
Guido Iaccarino post-doc 1996-1999 Duke University / HHMI (Neurotree)
David S Feldman post-doc 1997-2000 Duke University / HHMI (Neurotree)
Makoto R. Hara post-doc 2006-2012 Duke (Neurotree)
Alem Kahsai research scientist Duke (Chemistry Tree)
Jihee Kim research scientist Duke (Neurotree)
Martin J. Lohse research scientist Duke University / HHMI (Neurotree)
Lindsay Rein research scientist Duke (Neurotree)
Jim Wisler research scientist Duke (Neurotree)
Jennifer J. Linderman research scientist 1996-1997 Duke (Neurotree)
Michael E Rockman research scientist 2009-2010 Duke (Chemistry Tree)
Kurt D. Newman division chief Duke (Pediatric Surgery Tree)

Collaborators

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Abraham White collaborator 1975-1981 Duke (Chemistry Tree)
Bruno Giros collaborator 1992-1994 Duke University Medical Center (Neurotree)
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Publications

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Asher WB, Terry DS, Gregorio GGA, et al. (2022) GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision. Cell
Utz PJ, Jain MK, Cheung VG, et al. (2022) Translating science to medicine: The case for physician-scientists. Science Translational Medicine. 14: eabg7852
Zang Y, Kahsai AW, Pakharukova N, et al. (2021) The GPCR-β-arrestin complex allosterically activates C-Raf by binding its amino-terminus. The Journal of Biological Chemistry. 101369
Pani B, Ahn S, Rambarat PK, et al. (2021) . Molecular Pharmacology
Wang J, Pani B, Gokhan I, et al. (2021) β-arrestin-biased allosteric modulator potentiates Carvedilol stimulated β adrenergic receptor cardioprotection. Molecular Pharmacology
Nguyen AH, Lefkowitz RJ. (2021) Signaling at the endosome: cryo-EM structure of a GPCR-G protein-beta-arrestin megacomplex. The Febs Journal
Pakharukova N, Masoudi A, Pani B, et al. (2020) Allosteric activation of proto-oncogene kinase Src by GPCR-beta-arrestin complexes. The Journal of Biological Chemistry. 295: 16773-16784
Pakharukova N, Masoudi A, Pani B, et al. (2020) Allosteric activation of proto-oncogene kinase Src by GPCR-beta-arrestin complexes. The Journal of Biological Chemistry
Ahn S, Shenoy SK, Luttrell LM, et al. (2020) SnapShot: β-Arrestin Functions. Cell. 182: 1362-1362.e1
McMahon C, Staus DP, Wingler LM, et al. (2020) Synthetic nanobodies as angiotensin receptor blockers. Proceedings of the National Academy of Sciences of the United States of America
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