Robert J. Lefkowitz
Affiliations: | Duke University, Durham, NC |
Area:
G protein-coupled receptorsWebsite:
http://cardiology.medicine.duke.edu/faculty/details/0096962Google:
"Robert Lefkowitz"Bio:
The Nobel Prize in Chemistry 2012 was awarded jointly to Robert J. Lefkowitz and Brian K. Kobilka "for studies of G-protein-coupled receptors."
Cross-listing: Neurotree - Chemistry Tree
Parents
Sign in to add mentor| Ira Pastan | post-doc | 1968-1970 | NIH (Neurotree) |
| Jesse Roth | post-doc | 1968-1970 | NIH (Neurotree) |
| Edgar Haber | post-doc | 1970-1973 | Harvard Medical School (Neurotree) |
Children
Sign in to add trainee| Ronald D. Vale | research assistant | Duke Medical School | |
| Jeffery Benovic | grad student | Duke (Neurotree) | |
| Tom Cahill | grad student | Duke (Neurotree) | |
| Henrik G. Dohlman | grad student | Duke University / HHMI (Physics Tree) | |
| Anthony Nguyen | grad student | Duke (Neurotree) | |
| Robert W. Walters | grad student | Duke (Neurotree) | |
| Seungkirl Ahn | grad student | 2002 | Duke (Neurotree) |
| Alberuni M. Zamah | grad student | 2002 | Duke (Neurotree) |
| Christopher D Nelson | grad student | 2002-2007 | Duke (Neurotree) |
| Kelly N. Nobles | grad student | 2010 | Duke (Neurotree) |
| Minjung Choi | grad student | 2012-2018 | Duke (Neurotree) |
| Shahab Akhter | post-doc | Duke (Neurotree) | |
| R. Wayne Alexander | post-doc | Duke (Neurotree) | |
| Lee Allen | post-doc | Duke (Neurotree) | |
| Jeffrey Arriza | post-doc | Duke (Neurotree) | |
| Haavard Attramadal | post-doc | Duke (Neurotree) | |
| William G. Barnes | post-doc | Duke (Neurotree) | |
| Jeffrey L. Benovic | post-doc | Duke | |
| Tim Van Biesen | post-doc | Duke (Neurotree) | |
| Nanette H. Bishopric | post-doc | Duke | |
| Jeremy T. Blitzer | post-doc | Duke (FlyTree) | |
| Mark Bolanowski | post-doc | Duke (Neurotree) | |
| Erin Bressler | post-doc | Duke (Neurotree) | |
| Margaret Briggs-Gowan | post-doc | Duke (Neurotree) | |
| Ernst Burgisser | post-doc | Duke (Neurotree) | |
| Sheng Cai | post-doc | Duke (Neurotree) | |
| Paul G. Campbell | post-doc | Duke (Literature Tree) | |
| Mei Wang Casey | post-doc | Duke (Neurotree) | |
| Arnab K. Chatterjee | post-doc | Duke (Chemistry Tree) | |
| Minyong Chen | post-doc | Duke (Chemistry Tree) | |
| Jing Ruth Chen | post-doc | Duke (Neurotree) | |
| Wei Chen | post-doc | Duke (Physics Tree) | |
| Yishan Cheng | post-doc | Duke (Neurotree) | |
| Minjung Choi | post-doc | Duke (Neurotree) | |
| Audrey Claing | post-doc | Duke (Neurotree) | |
| William T. Clarke | post-doc | Duke (Neurotree) | |
| Benjamin T. Cocanougher | post-doc | Duke University / HHMI (Chemistry Tree) | |
| Sheila Collins | post-doc | Duke (Neurotree) | |
| Mei Cong | post-doc | Duke (Neurotree) | |
| Susanna Cotecchia | post-doc | Duke (Neurotree) | |
| Yehia Daaka | post-doc | Duke University School of Medicine (Chemistry Tree) | |
| Laura Davidson | post-doc | Duke (Neurotree) | |
| Albert S. Davies | post-doc | Duke (MathTree) | |
| Andre DeLean | post-doc | Duke (Neurotree) | |
| Scott M. DeWire | post-doc | Duke (Microtree) | |
| Kenneth Dickinson | post-doc | Duke (Neurotree) | |
| Matthew T. Drake | post-doc | Duke (Chemistry Tree) | |
| Mark Drazner | post-doc | Duke (Neurotree) | |
| David M. Feldman | post-doc | Duke (Neurotree) | |
| Mark Fereshteh | post-doc | Duke (Neurotree) | |
| Michael E. Field | post-doc | Duke (Neurotree) | |
| Zoey Fredericks | post-doc | Duke (Neurotree) | |
| Neil Freedman | post-doc | Duke (Neurotree) | |
| Jennifer Freedman | post-doc | Duke (Neurotree) | |
| Tom Frielle | post-doc | Duke (Neurotree) | |
| Tiffany Garrison | post-doc | Duke (Neurotree) | |
| Diane GetsyPalmer | post-doc | Duke (Neurotree) | |
| Larry Goldstein | post-doc | Duke (FlyTree) | |
| Thomas Gore | post-doc | Duke (Neurotree) | |
| Emily M. Harris | post-doc | Duke (Neurotree) | |
| William Hausdorff | post-doc | Duke (Neurotree) | |
| Brian Hawes | post-doc | Duke (Neurotree) | |
| James Heinsimer | post-doc | Duke (Neurotree) | |
| Mark Hnatowich | post-doc | Duke (Neurotree) | |
| Brian Jeffrey Hoffman | post-doc | Duke (Chemistry Tree) | |
| Dan Houtz | post-doc | Duke (Neurotree) | |
| Liaoyuan Hu | post-doc | Duke (Neurotree) | |
| Liyin Huang | post-doc | Duke (Neurotree) | |
| Guido Iaccarino | post-doc | Duke (Neurotree) | |
| Christopher D. Ingersoll | post-doc | Duke (Biomechanics Tree) | |
| Richard Kent | post-doc | Duke (Biomechanics Tree) | |
| Khuda Dad Khan | post-doc | Duke (Neurotree) | |
| Klim King | post-doc | Duke (Neurotree) | |
| Michael Kjelsberg | post-doc | Duke (Neurotree) | |
| Andrew Kleist | post-doc | Duke (Neurotree) | |
| Bjoern Klink | post-doc | Duke (Neurotree) | |
| Walter Koch | post-doc | Duke (Neurotree) | |
| Trudy Kohout | post-doc | Duke (Neurotree) | |
| Jeffrey J. Kovacs | post-doc | Duke (Neurotree) | |
| Kathleen Krueger | post-doc | Duke (SocTree) | |
| Hitoshi Kurose | post-doc | Duke (Neurotree) | |
| Madan Kwatra | post-doc | Duke (Neurotree) | |
| Richard Lebovitz | post-doc | Duke (Neurotree) | |
| L. M. Fredrik Leeb-Lundberg | post-doc | Duke (Chemistry Tree) | |
| Stephen B. Liggett | post-doc | Duke | |
| Fannie Lin | post-doc | Duke (Neurotree) | |
| Yuan Lin | post-doc | Duke (Physics Tree) | |
| Mathew Lo | post-doc | Duke (Neurotree) | |
| Jon Lomasney | post-doc | Duke (Neurotree) | |
| Wulfing Lorenz | post-doc | Duke (Neurotree) | |
| Louis Luttrell | post-doc | Duke | |
| Sandy Macrae | post-doc | Duke (Neurotree) | |
| Negin P. Martin | post-doc | Duke (Chemistry Tree) | |
| Ali Masoudi | post-doc | Duke (Physics Tree) | |
| Ali Masoudi | post-doc | Duke Medical School (Neurotree) | |
| Hiroyaki Matsui | post-doc | Duke (Neurotree) | |
| Stuart Maudsley | post-doc | Duke (Neurotree) | |
| Federico Mayor | post-doc | Duke (Neurotree) | |
| Patsy McDonald | post-doc | Duke (Neurotree) | |
| Thomas Michel | post-doc | Duke (Neurotree) | |
| John Mickey | post-doc | Duke (Neurotree) | |
| Carmelo Milano | post-doc | Duke (Neurotree) | |
| William E. Miller | post-doc | Duke (Neurotree) | |
| Debra Mullikin-Kilpatrick | post-doc | Duke (Neurotree) | |
| Hiroyasu Nakata | post-doc | Duke (Neurotree) | |
| Ponnal Nambi | post-doc | Duke (Neurotree) | |
| Canan Nebigil | post-doc | Duke (Neurotree) | |
| Chris Nelson | post-doc | Duke (Neurotree) | |
| Brian F. O'Dowd | post-doc | Duke (Neurotree) | |
| Lina M. Obeid | post-doc | Duke (MathTree) | |
| James Onorato | post-doc | Duke (Neurotree) | |
| Martin Opperman | post-doc | Duke (Neurotree) | |
| Natalia Pakharukova | post-doc | Duke (Neurotree) | |
| Biswaranjan Pani | post-doc | Duke (Neurotree) | |
| Gang Pei | post-doc | Duke (Neurotree) | |
| Karsten Peppel | post-doc | Duke (Neurotree) | |
| Steve Perry | post-doc | Duke (Chemistry Tree) | |
| Kristen J. Pierce | post-doc | Duke (ID Tree) | |
| Linda J. Pike | post-doc | Duke (Chemistry Tree) | |
| Julie Pitcher | post-doc | Duke (Neurotree) | |
| Steve Plonk | post-doc | Duke (Neurotree) | |
| Tom Povsic | post-doc | Duke (Neurotree) | |
| Nadeem Rahman | post-doc | Duke (Neurotree) | |
| Michael Raisch | post-doc | Duke (Neurotree) | |
| Keshava Rajagopal | post-doc | Duke | |
| Sudar Rajagopal | post-doc | Duke (Neurotree) | |
| John C. Raymond | post-doc | Duke (Physics Tree) | |
| John W. Regan | post-doc | Duke (Neurotree) | |
| Rosana Reis | post-doc | Duke (Neurotree) | |
| Eric Reiter | post-doc | Duke (Neurotree) | |
| Xiu-Rong Ren | post-doc | Duke (Neurotree) | |
| Greg Della Rocca | post-doc | Duke (Neurotree) | |
| Neil Roth | post-doc | Duke (Neurotree) | |
| Greg Sabo | post-doc | Duke (Neurotree) | |
| Philippe Samama | post-doc | Duke (Neurotree) | |
| Mika Scheinin | post-doc | Duke (Neurotree) | |
| Douglas Schocken | post-doc | Duke (Neurotree) | |
| Debra A. Schwinn | post-doc | Duke (Neurotree) | |
| Sudha K. Shenoy | post-doc | Duke (Neurotree) | |
| Robert Shorr | post-doc | Duke (Neurotree) | |
| Arun K. Shukla | post-doc | Duke (Neurotree) | |
| Robert F. Spurney | post-doc | Duke (Neurotree) | |
| Dean Staus | post-doc | Duke (Neurotree) | |
| Gary L. Stiles | post-doc | Duke (Neurotree) | |
| Robert Stoffel | post-doc | Duke (Neurotree) | |
| Carl Stone | post-doc | Duke (Neurotree) | |
| Ryan Strachan | post-doc | Duke (Neurotree) | |
| Cathy Strader | post-doc | Duke (Neurotree) | |
| Ruth Strasser | post-doc | Duke (Neurotree) | |
| Daniel Stroik | post-doc | Duke (Neurotree) | |
| Berta Strulovici | post-doc | Duke (Neurotree) | |
| Jinpeng Sun | post-doc | Duke (Neurotree) | |
| Robert L. Tate | post-doc | Duke (Microtree) | |
| Blossom Tewelde | post-doc | Duke (Neurotree) | |
| Michael Tharp | post-doc | Duke (Neurotree) | |
| Alex Thomsen | post-doc | Duke (Neurotree) | |
| Akira Tohgo | post-doc | Duke (Neurotree) | |
| Kazushige Touhara | post-doc | Duke (Neurotree) | |
| Bie Shung Tsai | post-doc | Duke (Neurotree) | |
| Vivek Upadhyay | post-doc | Duke (Neurotree) | |
| Johnathan Violin | post-doc | Duke (Neurotree) | |
| Huijun Wei | post-doc | Duke (Chemistry Tree) | |
| Michael Wessels | post-doc | Duke (Neurotree) | |
| Erin J. Whalen | post-doc | Duke (Neurotree) | |
| Jarl Wikberg | post-doc | Duke (Neurotree) | |
| R. Sanders Williams | post-doc | Duke (Neurotree) | |
| Lewis T. Williams | post-doc | Duke (Neurotree) | |
| Laura M. Wingler | post-doc | Duke (Chemistry Tree) | |
| Dennis Scott Witherow | post-doc | Duke | |
| Kevin Xiao | post-doc | Duke (Neurotree) | |
| Helen Yao | post-doc | Duke (Neurotree) | |
| Takaaki Yoshimasa | post-doc | Duke (Neurotree) | |
| Musa Zamah | post-doc | Duke (Neurotree) | |
| Yunxiang Zang | post-doc | Duke (Neurotree) | |
| Dave Zidar | post-doc | Duke (Neurotree) | |
| Marc Caron | post-doc | 1973-1976 | Duke |
| Lee Limbird | post-doc | 1973-1978 | Duke (Neurotree) |
| Warren J. Strittmatter | post-doc | 1978-1978 | Duke (Neurotree) |
| Richard A. Cerione | post-doc | 1982-1985 | Duke University / HHMI (Chemistry Tree) |
| David R. Sibley | post-doc | 1983-1987 | Duke (Neurotree) |
| Brian K. Kobilka | post-doc | 1984-1989 | Duke (Chemistry Tree) |
| Michel Bouvier | post-doc | 1985-1989 | Université de Montréal (Neurotree) |
| James Inglese | post-doc | 1989-1994 | Duke (Neurotree) |
| Richard T Premont | post-doc | 1992-1997 | Duke University School of Medicine (Chemistry Tree) |
| Randy A. Hall | post-doc | 1996-1999 | Duke (Neurotree) |
| Guido Iaccarino | post-doc | 1996-1999 | Duke University / HHMI (Neurotree) |
| David S Feldman | post-doc | 1997-2000 | Duke University / HHMI (Neurotree) |
| Sudarshan Rajagopal | post-doc | 2008-2011 | Duke University School of Medicine (Chemistry Tree) |
| Makoto R. Hara | post-doc | 2006-2012 | Duke (Neurotree) |
| Alem Kahsai | research scientist | Duke (Chemistry Tree) | |
| Jihee Kim | research scientist | Duke (Neurotree) | |
| Lindsay Rein | research scientist | Duke (Neurotree) | |
| Paul J Shim | research scientist | (Neurotree) | |
| Jim Wisler | research scientist | Duke (Neurotree) | |
| Martin J. Lohse | research scientist | 1988-1990 | Duke University / HHMI (Neurotree) |
| Jennifer J. Linderman | research scientist | 1996-1997 | Duke (Neurotree) |
| Michael E Rockman | research scientist | 2009-2010 | Duke (Chemistry Tree) |
| Kurt D. Newman | division chief | Duke (Pediatric Surgery Tree) |
Collaborators
Sign in to add collaborator| Abraham White | collaborator | 1975-1981 | Duke (Chemistry Tree) |
| Bruno Giros | collaborator | 1992-1994 | Duke University Medical Center (Neurotree) |
BETA: Related publications
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Publications
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| Pakharukova N, Thomas BN, Bansia H, et al. (2024) Beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy. Biorxiv : the Preprint Server For Biology |
| Liu S, Anderson PJ, Rajagopal S, et al. (2024) G Protein-Coupled Receptors: A Century of Research and Discovery. Circulation Research. 135: 174-197 |
| Casiraghi M, Wang H, Brennan P, et al. (2024) Molecular insights into G protein specificity and biased agonism at the β -adrenergic receptor. Biorxiv : the Preprint Server For Biology |
| Rockman HA, Lefkowitz RJ. (2024) G protein-coupled receptors: from radioligand binding to cellular signaling. The Journal of Clinical Investigation. 134 |
| Lefkowitz RJ, Rockman HA, Shim PJ, et al. (2023) How carvedilol does not activate β-adrenoceptors. Nature Communications. 14: 7866 |
| Kahsai AW, Shah KS, Shim PJ, et al. (2023) Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin. Proceedings of the National Academy of Sciences of the United States of America. 120: e2303794120 |
| Ahn S, Maarsingh H, Walker JK, et al. (2023) Allosteric modulator potentiates β2AR agonist-promoted bronchoprotection in asthma models. The Journal of Clinical Investigation |
| Li A, Liu S, Huang R, et al. (2023) Loss of biased signaling at a G protein-coupled receptor in overexpressed systems. Plos One. 18: e0283477 |
| Asher WB, Terry DS, Gregorio GGA, et al. (2022) GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision. Cell |
| Utz PJ, Jain MK, Cheung VG, et al. (2022) Translating science to medicine: The case for physician-scientists. Science Translational Medicine. 14: eabg7852 |