Jacob G Kirkland, Ph.D.

2021- Cell Cycle and Cancer Biology Oklahoma Medical Research Foundation, USA 
chromatin, epigenetics, cancer


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Carlos Corvera research assistant 2004-2007 UCSF
Rohinton T. Kamakaka grad student 2007-2013 UC Santa Cruz
Gerald Crabtree post-doc 2014- Stanford Medical School (Neurotree)
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Weber CM, Hafner A, Kirkland JG, et al. (2021) mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution. Nature Structural & Molecular Biology. 28: 501-511
Chory EJ, Kirkland JG, Chang CY, et al. (2020) Chemical Inhibitors of a Selective SWI/SNF Function Synergize with ATR Inhibition in Cancer Cell Killing. Acs Chemical Biology
Seoane JA, Kirkland JG, Caswell-Jin JL, et al. (2019) Chromatin regulators mediate anthracycline sensitivity in breast cancer. Nature Medicine
Hamdani O, Dhillon N, Hsieh TS, et al. (2019) Transfer RNA Genes Affect Chromosome Structure and Function via Local Effects. Molecular and Cellular Biology
Seoane JA, Kirkland JG, Caswell-Jin JL, et al. (2019) Abstract 2108: Chromatin state as a mechanism of anthracycline response in breast cancer Cancer Research. 79: 2108-2108
Hodges HC, Stanton BZ, Cermakova K, et al. (2018) Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers. Nature Structural & Molecular Biology. 25: 61-72
Braun SMG, Kirkland JG, Chory EJ, et al. (2017) Rapid and reversible epigenome editing by endogenous chromatin regulators. Nature Communications. 8: 560
Hodges C, Kirkland JG, Crabtree GR. (2016) The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer. Cold Spring Harbor Perspectives in Medicine
Kirkland JG, Peterson MR, Still CD, et al. (2015) Heterochromatin formation via recruitment of DNA repair proteins. Molecular Biology of the Cell. 26: 1395-410
Snider CE, Stephens AD, Kirkland JG, et al. (2014) Dyskerin, tRNA genes, and condensin tether pericentric chromatin to the spindle axis in mitosis. The Journal of Cell Biology. 207: 189-99
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