Alfred LM Bothwell

Yale University School of Medicine, New Haven, CT 
Immunology, molecular biology, cancer
"Alfred Bothwell"


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Sidney Altman grad student 1971-1975 Graduate Student (Chemistry Tree)
Joseph Sambrook post-doc 1975-1976 CSHL (Neurotree)
David Baltimore post-doc 1976-1982 MIT
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Horowitz MC, Bothwell AL, Hesslein DG, et al. (2005) B cells and osteoblast and osteoclast development. Immunological Reviews. 208: 141-53
Horowitz MC, Xi Y, Pflugh DL, et al. (2004) Pax5-deficient mice exhibit early onset osteopenia with increased osteoclast progenitors. Journal of Immunology (Baltimore, Md. : 1950). 173: 6583-91
Johnson K, Pflugh DL, Yu D, et al. (2004) B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5. Nature Immunology. 5: 853-61
Hesslein DG, Pflugh DL, Chowdhury D, et al. (2003) Pax5 is required for recombination of transcribed, acetylated, 5' IgH V gene segments. Genes & Development. 17: 37-42
Khan KD, Shuai K, Lindwall G, et al. (1993) Induction of the Ly-6A/E gene by interferon alpha/beta and gamma requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein binds. Proceedings of the National Academy of Sciences of the United States of America. 90: 6806-10
Zhang F, Crise B, Su B, et al. (1992) The lateral mobility of some membrane proteins is determined by their ectodomains. Biophysical Journal. 62: 92-4
Zhang F, Crise B, Su B, et al. (1991) Lateral diffusion of membrane-spanning and glycosylphosphatidylinositol-linked proteins: toward establishing rules governing the lateral mobility of membrane proteins. The Journal of Cell Biology. 115: 75-84
Bothwell AL, Paskind M, Reth M, et al. (1982) Somatic variants of murine immunoglobulin lambda light chains. Nature. 298: 380-2
Bothwell AL, Paskind M, Reth M, et al. (1981) Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region. Cell. 24: 625-37
Mather EL, Alt FW, Bothwell AL, et al. (1981) Expression of J chain RNA in cell lines representing different stages of B lymphocyte differentiation. Cell. 23: 369-78
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