Jonathan J Miner, MD/PhD
Affiliations: | 2017-2021 | Medicine | Washington University School of Medicine, St. Louis, MO, United States |
| 2021- | Medicine | University of Pennsylvania, Philadelphia, PA, United States |
Area:
Rare diseases, gene therapies, TREX1, RVCL, STING, SAVI, host-microbe interactions, cell-intrinsic innate immunity, autoimmunity, virology, rheumatologyWebsite:
https://www.med.upenn.edu/rvcl/Google:
"Jonathan Miner"Parents
Sign in to add mentor| Rodger P. McEver | grad student | 2002-2008 | University of Oklahoma College of Medicine, OMRF |
| Michael S. Diamond | post-doc | 2013-2017 | Washington University School Medicine (Neurotree) |
Children
Sign in to add trainee| Samuel D Chauvin | grad student | 2022- | Penn |
| Derek J. Platt | grad student | 2017-2021 | Washington University School of Medicine |
| Joe Holley | post-doc | 2021- | Penn |
| Subhajit Poddar | research scientist | 2021- | Penn |
Collaborators
Sign in to add collaborator| Megan T. Baldridge | collaborator | 2017- | Washington University School of Medicine |
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Publications
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| Chauvin SD, Ando S, Holley JA, et al. (2024) Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans. Nature Communications. 15: 4696 |
| Chauvin SD, Stinson WA, Platt DJ, et al. (2023) Regulation of cGAS and STING signaling during inflammation and infection. The Journal of Biological Chemistry. 104866 |
| Stinson WA, Miner CA, Zhao FR, et al. (2022) The IFN-γ receptor promotes immune dysregulation and disease in STING gain-of-function mice. Jci Insight. 7 |
| Platt DJ, Lawrence D, Rodgers R, et al. (2021) Transferrable protection by gut microbes against STING-associated lung disease. Cell Reports. 35: 109113 |
| Walker FC, Hassan E, Peterson ST, et al. (2021) Norovirus evolution in immunodeficient mice reveals potentiated pathogenicity via a single nucleotide change in the viral capsid. Plos Pathogens. 17: e1009402 |
| Rhee RL, Lu J, Bittinger K, et al. (2021) Dynamic Changes in the Nasal Microbiome Associated with Disease Activity in Patients with Granulomatosis with Polyangiitis. Arthritis & Rheumatology (Hoboken, N.J.) |
| Miner JJ, Platt DJ, Ghaznavi CM, et al. (2020) HSV-1 and Zika Virus but Not SARS-CoV-2 Replicate in the Human Cornea and Are Restricted by Corneal Type III Interferon. Cell Reports. 33: 108339 |
| Ford AL, Chin VW, Fellah S, et al. (2020) Lesion evolution and neurodegeneration in RVCL-S: A monogenic microvasculopathy. Neurology |
| Platt DJ, Miner JJ. (2020) Immunopathology of Zika virus infection. Advances in Virus Research. 107: 223-246 |
| Bennion BG, Croft CA, Ai TL, et al. (2020) STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice. Cell Reports. 31: 107771 |