Jason R. Burke

Affiliations: 
2012 Chemistry University of California, Santa Cruz, Santa Cruz, CA, United States 
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"Jason Burke"

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Seth M. Rubin grad student 2012 UC Santa Cruz
 (Structural studies of retinoblastoma protein phosphorylation.)
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Publications

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Wolf-Saxon ER, Moorman CC, Castro A, et al. (2023) Regulatory ligand binding in plant chalcone isomerase-like (CHIL) proteins. The Journal of Biological Chemistry. 104804
Burke JR, La Clair JJ, Philippe RN, et al. (2019) Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases Acs Catalysis. 9: 8388-8396
Kaltenbach M, Burke JR, Dindo M, et al. (2018) Evolution of chalcone isomerase from a noncatalytic ancestor. Nature Chemical Biology
Pye CR, Bray WM, Brown ER, et al. (2016) A Strategy for Direct Chemical Activation of the Retinoblastoma Protein. Acs Chemical Biology
Tokarski JS, Zupa-Fernandez A, Tredup JA, et al. (2015) Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain. The Journal of Biological Chemistry. 290: 11061-74
Burke JR, Liban TJ, Restrepo T, et al. (2014) Multiple mechanisms for E2F binding inhibition by phosphorylation of the retinoblastoma protein C-terminal domain. Journal of Molecular Biology. 426: 245-55
Burke JR, Hura GL, Rubin SM. (2012) Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control. Genes & Development. 26: 1156-66
Balog ER, Burke JR, Hura GL, et al. (2011) Crystal structure of the unliganded retinoblastoma protein pocket domain. Proteins. 79: 2010-4
Burke JR, Deshong AJ, Pelton JG, et al. (2010) Phosphorylation-induced conformational changes in the retinoblastoma protein inhibit E2F transactivation domain binding. The Journal of Biological Chemistry. 285: 16286-93
Burke JR, Pelton JG, Rubin SM. (2010) Molecular Mechanisms for Phosphorylation Driven Dissociation of Rb-E2F Complexes Biophysical Journal. 98: 235a
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