| Year |
Citation |
Score |
| 2023 |
Konstantinidou M, Visser EJ, Vandenboorn E, Chen S, Jaishankar P, Overmans M, Dutta S, Neitz RJ, Renslo AR, Ottmann C, Brunsveld L, Arkin MR. Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein-Protein Interaction from Nonselective Fragments. Journal of the American Chemical Society. PMID 37676236 DOI: 10.1021/jacs.3c05161 |
0.305 |
|
| 2023 |
Gahbauer S, Correy GJ, Schuller M, Ferla MP, Doruk YU, Rachman M, Wu T, Diolaiti M, Wang S, Neitz RJ, Fearon D, Radchenko DS, Moroz YS, Irwin JJ, Renslo AR, et al. Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America. 120: e2212931120. PMID 36598939 DOI: 10.1073/pnas.2212931120 |
0.34 |
|
| 2022 |
Gahbauer S, Correy GJ, Schuller M, Ferla MP, Doruk YU, Rachman M, Wu T, Diolaiti M, Wang S, Neitz RJ, Fearon D, Radchenko D, Moroz Y, Irwin JJ, Renslo AR, et al. Structure-based inhibitor optimization for the Nsp3 Macrodomain of SARS-CoV-2. Biorxiv : the Preprint Server For Biology. PMID 35794891 DOI: 10.1101/2022.06.27.497816 |
0.377 |
|
| 2018 |
LaPorte MG, Burnett JC, Colombo R, Bulfer SL, Alverez C, Chou TF, Neitz RJ, Green N, Moore WJ, Yue Z, Li S, Arkin MR, Wipf P, Huryn DM. Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97. Acs Medicinal Chemistry Letters. 9: 1075-1081. PMID 30429948 DOI: 10.1021/Acsmedchemlett.8B00372 |
0.53 |
|
| 2016 |
Alverez C, Bulfer SL, Chakrasali R, Chimenti MS, Deshaies RJ, Green N, Kelly M, LaPorte MG, Lewis TS, Liang M, Moore WJ, Neitz RJ, Peshkov VA, Walters MA, Zhang F, et al. Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway. Acs Medicinal Chemistry Letters. 7: 182-7. PMID 26985295 DOI: 10.1021/Acsmedchemlett.5B00396 |
0.482 |
|
| 2016 |
Banerjee S, Bartesaghi A, Merk A, Rao P, Bulfer SL, Yan Y, Green N, Mroczkowski B, Neitz RJ, Wipf P, Falconieri V, Deshaies RJ, Milne JL, Huryn D, Arkin M, et al. 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition. Science (New York, N.Y.). PMID 26822609 DOI: 10.1126/Science.Aad7974 |
0.375 |
|
| 2016 |
Long T, Neitz RJ, Beasley R, Kalyanaraman C, Suzuki BM, Jacobson MP, Dissous C, McKerrow JH, Drewry DH, Zuercher WJ, Singh R, Caffrey CR. Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni. Plos Neglected Tropical Diseases. 10: e0004356. PMID 26751972 DOI: 10.1371/Journal.Pntd.0004356 |
0.309 |
|
| 2016 |
Alverez C, Bulfer SL, Chakrasali R, Chimenti MS, Deshaies RJ, Green N, Kelly M, LaPorte MG, Lewis TS, Liang M, Moore WJ, Neitz RJ, Peshkov VA, Walters MA, Zhang F, et al. Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway Acs Medicinal Chemistry Letters. 7: 182-187. DOI: 10.1021/acsmedchemlett.5b00396 |
0.427 |
|
| 2015 |
Alverez C, Arkin MR, Bulfer SL, Colombo R, Kovaliov M, LaPorte MG, Lim C, Liang M, Moore WJ, Neitz RJ, Yan Y, Yue Z, Huryn DM, Wipf P. Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97. Acs Medicinal Chemistry Letters. 6: 1225-30. PMID 26713109 DOI: 10.1021/Acsmedchemlett.5B00364 |
0.548 |
|
| 2015 |
Neitz RJ, Bryant C, Chen S, Gut J, Hugo Caselli E, Ponce S, Chowdhury S, Xu H, Arkin MR, Ellman JA, Renslo AR. Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease. Bioorganic & Medicinal Chemistry Letters. 25: 4834-7. PMID 26144347 DOI: 10.1016/J.Bmcl.2015.06.066 |
0.472 |
|
| 2015 |
Alverez C, Arkin MR, Bulfer SL, Colombo R, Kovaliov M, Laporte MG, Lim C, Liang M, Moore WJ, Neitz RJ, Yan Y, Yue Z, Huryn DM, Wipf P. Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97 Acs Medicinal Chemistry Letters. 6: 1225-1230. DOI: 10.1021/acsmedchemlett.5b00364 |
0.617 |
|
| 2013 |
Ng RA, Sun M, Bowers S, Hom RK, Probst GD, John V, Fang LY, Maillard M, Gailunas A, Brogley L, Neitz RJ, Tung JS, Pleiss MA, Konradi AW, Sham HL, et al. Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 4674-9. PMID 23856050 DOI: 10.1016/j.bmcl.2013.06.006 |
0.527 |
|
| 2013 |
Bowers S, Truong AP, Ye M, Aubele DL, Sealy JM, Neitz RJ, Hom RK, Chan W, Dappen MS, Galemmo RA, Konradi AW, Sham HL, Zhu YL, Beroza P, Tonn G, et al. Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 2743-9. PMID 23522834 DOI: 10.1016/J.Bmcl.2013.02.065 |
0.387 |
|
| 2013 |
Garofalo AW, Adler M, Aubele DL, Bowers S, Franzini M, Goldbach E, Lorentzen C, Neitz RJ, Probst GD, Quinn KP, Santiago P, Sham HL, Tam D, Truong AP, Ye XM, et al. Novel cinnoline-based inhibitors of LRRK2 kinase activity. Bioorganic & Medicinal Chemistry Letters. 23: 71-4. PMID 23219325 DOI: 10.1016/J.Bmcl.2012.11.021 |
0.325 |
|
| 2011 |
Neitz RJ, Konradi AW, Sham HL, Zmolek W, Wong K, Qin A, Lorentzen C, Nakamura D, Quinn KP, Sauer JM, Powell K, Ruslim L, Chereau D, Ren Z, Anderson J, et al. Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement. Bioorganic & Medicinal Chemistry Letters. 21: 3726-9. PMID 21570836 DOI: 10.1016/j.bmcl.2011.04.074 |
0.36 |
|
| 2011 |
Bowers S, Truong AP, Neitz RJ, Neitzel M, Probst GD, Hom RK, Peterson B, Galemmo RA, Konradi AW, Sham HL, Tóth G, Pan H, Yao N, Artis DR, Brigham EF, et al. Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor. Bioorganic & Medicinal Chemistry Letters. 21: 1838-43. PMID 21316234 DOI: 10.1016/j.bmcl.2011.01.046 |
0.447 |
|
| 2010 |
Hom RK, Bowers S, Sealy JM, Truong AP, Probst GD, Neitzel ML, Neitz RJ, Fang L, Brogley L, Wu J, Konradi AW, Sham HL, Tóth G, Pan H, Yao N, et al. Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK. Bioorganic & Medicinal Chemistry Letters. 20: 7303-7. PMID 21071223 DOI: 10.1016/j.bmcl.2010.10.066 |
0.478 |
|
| 2004 |
Roush WR, Neitz RJ. Studies on the synthesis of landomycin A. Synthesis of the originally assigned structure of the aglycone, landomycinone, and revision of structure. The Journal of Organic Chemistry. 69: 4906-12. PMID 15255715 DOI: 10.1021/Jo049426C |
0.474 |
|
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