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Lance M. Hellman, Ph.D. - Publications

Affiliations: 
University of Kentucky, Lexington, KY 
Area:
Protein-nucleic acid interactions
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Singh NK, Alonso JA, Devlin JR, Keller GLJ, Gray GI, Chiranjivi AK, Foote SG, Landau LM, Arbuiso AG, Weiss LI, Rosenberg AM, Hellman LM, Nishimura MI, Baker BM. A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometry. Nature Communications. 13: 7189. PMID 36424374 DOI: 10.1038/s41467-022-34896-0  0.806
2022 Liu C, Liu H, Dasgupta M, Hellman LM, Zhang X, Qu K, Xue H, Wang Y, Fan F, Chang Q, Yu D, Ge L, Zhang Y, Cui Z, Zhang P, et al. Validation and promise of a TCR mimic antibody for cancer immunotherapy of hepatocellular carcinoma. Scientific Reports. 12: 12068. PMID 35840635 DOI: 10.1038/s41598-022-15946-5  0.6
2021 Ma J, Ayres CM, Hellman LM, Devlin JR, Baker BM. Dynamic allostery controls the peptide sensitivity of the Ly49C natural killer receptor. The Journal of Biological Chemistry. 100686. PMID 33891944 DOI: 10.1016/j.jbc.2021.100686  0.615
2021 Smith AR, Alonso JA, Ayres CM, Singh NK, Hellman LM, Baker BM. Structurally silent peptide anchor modifications allosterically modulate T cell recognition in a receptor-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33468649 DOI: 10.1073/pnas.2018125118  0.82
2020 Singh NK, Alonso JA, Harris DT, Anderson SD, Ma J, Hellman LM, Rosenberg AM, Kolawole EM, Evavold BD, Kranz DM, Baker BM. An Engineered T Cell Receptor Variant Realizes the Limits of Functional Binding Modes. Biochemistry. PMID 33074657 DOI: 10.1021/acs.biochem.0c00689  0.825
2019 Ayres CM, Abualrous ET, Bailey A, Abraham C, Hellman LM, Corcelli SA, Noé F, Elliott T, Baker BM. Dynamically Driven Allostery in MHC Proteins: Peptide-Dependent Tuning of Class I MHC Global Flexibility. Frontiers in Immunology. 10: 966. PMID 31130956 DOI: 10.3389/Fimmu.2019.00966  0.665
2018 Hellman LM, Foley KC, Singh NK, Alonso JA, Riley TP, Devlin JR, Ayres CM, Keller GLJ, Zhang Y, Vander Kooi CW, Nishimura MI, Baker BM. Improving T Cell Receptor On-Target Specificity via Structure-Guided Design. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 30617019 DOI: 10.1016/J.Ymthe.2018.12.010  0.784
2018 Riley TP, Hellman LM, Gee MH, Mendoza JL, Alonso JA, Foley KC, Nishimura MI, Vander Kooi CW, Garcia KC, Baker BM. T cell receptor cross-reactivity expanded by dramatic peptide-MHC adaptability. Nature Chemical Biology. 14: 934-942. PMID 30224695 DOI: 10.1038/S41589-018-0130-4  0.805
2018 Spear TT, Wang Y, Smith TW, Simms PE, Garrett-Mayer E, Hellman LM, Baker BM, Nishimura MI. Altered Peptide Ligands Impact the Diversity of Polyfunctional Phenotypes in T Cell Receptor Gene-Modified T Cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 29503203 DOI: 10.1016/J.Ymthe.2018.01.015  0.686
2017 Moore T, Wagner CR, Scurti GM, Hutchens KA, Godellas C, Clark AL, Kolawole EM, Hellman LM, Singh NK, Huyke FA, Wang SY, Calabrese KM, Embree HD, Orentas R, Shirai K, et al. Correction to: Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells. Cancer Immunology, Immunotherapy : Cii. PMID 29264697 DOI: 10.1007/S00262-017-2102-Z  0.698
2017 Moore T, Wagner CR, Scurti GM, Hutchens KA, Godellas C, Clark AL, Kolawole EM, Hellman LM, Singh NK, Huyke FA, Wang SY, Calabrese KM, Embree HD, Orentas R, Shirai K, et al. Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells. Cancer Immunology, Immunotherapy : Cii. PMID 29052782 DOI: 10.1007/S00262-017-2073-0  0.717
2017 Spear TT, Wang Y, Foley KC, Murray DC, Scurti GM, Simms PE, Garrett-Mayer E, Hellman LM, Baker BM, Nishimura MI. Critical biological parameters modulate affinity as a determinant of function in T-cell receptor gene-modified T-cells. Cancer Immunology, Immunotherapy : Cii. PMID 28634816 DOI: 10.1007/S00262-017-2032-9  0.685
2017 Wang Y, Singh NK, Spear TT, Hellman LM, Piepenbrink KH, McMahan RH, Rosen HR, Vander Kooi CW, Nishimura MI, Baker BM. How an alloreactive T-cell receptor achieves peptide and MHC specificity. Proceedings of the National Academy of Sciences of the United States of America. PMID 28572406 DOI: 10.1073/Pnas.1700459114  0.79
2016 Riley TP, Ayres CM, Hellman LM, Singh NK, Cosiano M, Cimons JM, Anderson MJ, Piepenbrink KH, Pierce BG, Weng Z, Baker BM. A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces. Protein Engineering, Design & Selection : Peds. PMID 27624308 DOI: 10.1093/Protein/Gzw050  0.774
2016 Spear TT, Riley TP, Lyons GE, Callender GG, Roszkowski JJ, Wang Y, Simms PE, Scurti GM, Foley KC, Murray DC, Hellman LM, McMahan RH, Iwashima M, Garrett-Mayer E, Rosen HR, et al. Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability. Journal of Leukocyte Biology. PMID 26921345 DOI: 10.1189/Jlb.2A1215-561R  0.791
2016 Hellman LM, Yin L, Wang Y, Blevins SJ, Riley TP, Belden OS, Spear TT, Nishimura MI, Stern LJ, Baker BM. Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide-MHC complexes. Journal of Immunological Methods. PMID 26906089 DOI: 10.1016/J.Jim.2016.02.016  0.763
2016 Chicka MC, Ren Q, Richards D, Hellman LM, Zhang J, Fried MG, Whiteheart SW. Role of Munc13-4 as a Ca2+-dependent tether during platelet secretion. The Biochemical Journal. 473: 627-39. PMID 26637270 DOI: 10.1042/Bj20151150  0.458
2015 Thompson MG, Larson M, Vidrine A, Barrios K, Navarro F, Meyers K, Simms P, Prajapati K, Chitsike L, Hellman LM, Baker BM, Watkins SK. FOXO3-NF-κB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function. Journal of Immunology (Baltimore, Md. : 1950). PMID 26561547 DOI: 10.4049/Jimmunol.1501758  0.539
2014 Hellman LM, Spear TJ, Koontz CJ, Melikishvili M, Fried MG. Repair of O6-methylguanine adducts in human telomeric G-quadruplex DNA by O6-alkylguanine-DNA alkyltransferase. Nucleic Acids Research. 42: 9781-91. PMID 25080506 DOI: 10.1093/Nar/Gku659  0.443
2014 Pierce BG, Hellman LM, Hossain M, Singh NK, Vander Kooi CW, Weng Z, Baker BM. Computational design of the affinity and specificity of a therapeutic T cell receptor. Plos Computational Biology. 10: e1003478. PMID 24550723 DOI: 10.1371/Journal.Pcbi.1003478  0.825
2014 Pierce BG, Hellman LM, Hossain M, Singh NK, Kooi CWV, Weng Z, Baker BM. Scores from ZAFFI (ZF) and Rosetta (Ros), predicted peptide contacts, and measured energies (in kcal/mol) for DMF5 point mutants binding to ELA/HLA-A2 and AAG/HLA-A2. Plos Computational Biology. DOI: 10.1371/Journal.Pcbi.1003478.T002  0.764
2013 Smith EC, Smith SE, Carter JR, Webb SR, Gibson KM, Hellman LM, Fried MG, Dutch RE. Trimeric transmembrane domain interactions in paramyxovirus fusion proteins: roles in protein folding, stability, and function. The Journal of Biological Chemistry. 288: 35726-35. PMID 24178297 DOI: 10.1074/Jbc.M113.514554  0.522
2013 Lee M, Artola-Recolons C, Carrasco-López C, Martínez-Caballero S, Hesek D, Spink E, Lastochkin E, Zhang W, Hellman LM, Boggess B, Hermoso JA, Mobashery S. Cell-wall remodeling by the zinc-protease AmpDh3 from Pseudomonas aeruginosa. Journal of the American Chemical Society. 135: 12604-7. PMID 23931161 DOI: 10.1021/Ja407445X  0.315
2012 Hawse WF, Champion MM, Joyce MV, Hellman LM, Hossain M, Ryan V, Pierce BG, Weng Z, Baker BM. Cutting edge: Evidence for a dynamically driven T cell signaling mechanism. Journal of Immunology (Baltimore, Md. : 1950). 188: 5819-23. PMID 22611242 DOI: 10.4049/Jimmunol.1200952  0.799
2012 Smith EC, Culler MR, Hellman LM, Fried MG, Creamer TP, Dutch RE. Beyond anchoring: the expanding role of the hendra virus fusion protein transmembrane domain in protein folding, stability, and function. Journal of Virology. 86: 3003-13. PMID 22238302 DOI: 10.1128/Jvi.05762-11  0.506
2012 Popa A, Carter JR, Smith SE, Hellman L, Fried MG, Dutch RE. Residues in the hendra virus fusion protein transmembrane domain are critical for endocytic recycling. Journal of Virology. 86: 3014-26. PMID 22238299 DOI: 10.1128/Jvi.05826-11  0.449
2012 Elverson HE, Hellman LM, Melikishvili M, Zhao C, Whiteheart SW, Fried MG. Histidine-Tag-Specific Optical Probes for Analytical Ultracentrifugation Analysis Biophysical Journal. 102: 483a-484a. DOI: 10.1016/J.Bpj.2011.11.2650  0.539
2011 Hellman LM, Zhao C, Melikishvili M, Tao X, Hopper JE, Whiteheart SW, Fried MG. Histidine-tag-directed chromophores for tracer analyses in the analytical ultracentrifuge. Methods (San Diego, Calif.). 54: 31-8. PMID 21187151 DOI: 10.1016/J.Ymeth.2010.12.033  0.478
2010 Parker MW, Hellman LM, Xu P, Fried MG, Vander Kooi CW. Furin processing of semaphorin 3F determines its anti-angiogenic activity by regulating direct binding and competition for neuropilin. Biochemistry. 49: 4068-75. PMID 20387901 DOI: 10.1021/Bi100327R  0.487
2010 Zhao C, Hellman LM, Zhan X, Bowman WS, Whiteheart SW, Fried MG. Hexahistidine-tag-specific optical probes for analyses of proteins and their interactions. Analytical Biochemistry. 399: 237-45. PMID 20036207 DOI: 10.1016/J.Ab.2009.12.028  0.532
2010 Hellman LM, Rodgers DW, Fried MG. Phenomenological partial-specific volumes for G-quadruplex DNAs. European Biophysics Journal : Ebj. 39: 389-96. PMID 19238377 DOI: 10.1007/S00249-009-0411-7  0.454
2010 Zhao C, Hellman LM, Zhan X, Whiteheart SW, Fried MG. (his)6-Tag-Specific Optical Probes For Analyses of Proteins and Their Interactions Biophysical Journal. 98: 60a. DOI: 10.1016/J.Bpj.2009.12.345  0.528
2009 Melikishvili M, Hellman LM, Fried MG. Use of DNA length variation to detect periodicities in positively cooperative, nonspecific binding. Methods in Enzymology. 466: 65-81. PMID 21609858 DOI: 10.1016/S0076-6879(09)66004-3  0.49
2008 Hellman LM, Tackett WJ, Lawson EL, Fried MG. Cold Denaturation of Quadruplex DNA The Faseb Journal. 22: 192-192. DOI: 10.1096/Fasebj.22.2_Supplement.192  0.42
2007 Hellman LM, Fried MG. Electrophoretic mobility shift assay (EMSA) for detecting protein-nucleic acid interactions. Nature Protocols. 2: 1849-61. PMID 17703195 DOI: 10.1038/Nprot.2007.249  0.463
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