| Year |
Citation |
Score |
| 2023 |
Carrasco Pro S, Hook H, Bray D, Berenzy D, Moyer D, Yin M, Labadorf AT, Tewhey R, Siggers T, Fuxman Bass JI. Widespread perturbation of ETS factor binding sites in cancer. Nature Communications. 14: 913. PMID 36808133 DOI: 10.1038/s41467-023-36535-8 |
0.325 |
|
| 2022 |
Bray D, Hook H, Zhao R, Keenan JL, Penvose A, Osayame Y, Mohaghegh N, Chen X, Parameswaran S, Kottyan LC, Weirauch MT, Siggers T. CASCADE: high-throughput characterization of regulatory complex binding altered by non-coding variants. Cell Genomics. 2. PMID 35252945 DOI: 10.1016/j.xgen.2022.100098 |
0.438 |
|
| 2022 |
Hook H, Zhao RW, Bray D, Keenan JL, Siggers T. High-Throughput Analysis of the Cell and DNA Site-Specific Binding of Native NF-κB Dimers Using Nuclear Extract Protein-Binding Microarrays (NextPBMs). Methods in Molecular Biology (Clifton, N.J.). 2366: 43-66. PMID 34236632 DOI: 10.1007/978-1-0716-1669-7_4 |
0.509 |
|
| 2021 |
Williams LM, Sridhar S, Samaroo J, Peart J, Adindu EK, Addanki A, DiRusso CJ, Aguirre Carrión PJ, Rodriguez-Sastre N, Siggers T, Gilmore TD. Comparison of NF-κB from the protists Capsaspora owczarzaki and Acanthoeca spectabilis reveals extensive evolutionary diversification of this transcription factor. Communications Biology. 4: 1404. PMID 34916615 DOI: 10.1038/s42003-021-02924-2 |
0.445 |
|
| 2019 |
Williams LM, Inge MM, Mansfield KM, Rasmussen A, Afghani J, Agrba M, Albert C, Andersson C, Babaei M, Babaei M, Bagdasaryants A, Bonilla A, Browne A, Carpenter S, Chen T, ... ... Siggers T, et al. Transcription factor NF-κB in a basal metazoan, the sponge, has conserved and unique sequences, activities, and regulation. Developmental and Comparative Immunology. 103559. PMID 31751628 DOI: 10.1016/J.Dci.2019.103559 |
0.452 |
|
| 2019 |
Bruno L, Ramlall V, Studer RA, Sauer S, Bradley D, Dharmalingam G, Carroll T, Ghoneim M, Chopin M, Nutt SL, Elderkin S, Rueda DS, Fisher AG, Siggers T, Beltrao P, et al. Selective deployment of transcription factor paralogs with submaximal strength facilitates gene regulation in the immune system. Nature Immunology. PMID 31451789 DOI: 10.1038/S41590-019-0471-5 |
0.406 |
|
| 2019 |
Penvose A, Keenan JL, Bray D, Ramlall V, Siggers T. Comprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity. Nature Communications. 10: 2514. PMID 31175293 DOI: 10.1038/S41467-019-10264-3 |
0.565 |
|
| 2019 |
Mohaghegh N, Bray D, Keenan J, Penvose A, Andrilenas KK, Ramlall V, Siggers T. NextPBM: a platform to study cell-specific transcription factor binding and cooperativity. Nucleic Acids Research. 47: e31. PMID 30657937 DOI: 10.1093/Nar/Gkz020 |
0.573 |
|
| 2018 |
Andrilenas KK, Ramlall V, Kurland J, Leung B, Harbaugh AG, Siggers T. DNA-binding landscape of IRF3, IRF5 and IRF7 dimers: implications for dimer-specific gene regulation. Nucleic Acids Research. PMID 29361124 DOI: 10.1093/Nar/Gky002 |
0.586 |
|
| 2017 |
Mansfield KM, Carter NM, Nguyen L, Cleves PA, Alshanbayeva A, Williams LM, Crowder C, Penvose AR, Finnerty JR, Weis VM, Siggers TW, Gilmore TD. Transcription factor NF-κB is modulated by symbiotic status in a sea anemone model of cnidarian bleaching. Scientific Reports. 7: 16025. PMID 29167511 DOI: 10.1038/S41598-017-16168-W |
0.39 |
|
| 2016 |
Kuzu G, Kaye EG, Chery J, Siggers T, Yang L, Dobson JR, Boor S, Bliss J, Liu W, Jogl G, Rohs R, Singh ND, Bulyk ML, Tolstorukov MY, Larschan E. Expansion of GA Dinucleotide Repeats Increases the Density of CLAMP Binding Sites on the X-Chromosome to Promote Drosophila Dosage Compensation. Plos Genetics. 12: e1006120. PMID 27414415 DOI: 10.1371/Journal.Pgen.1006120 |
0.346 |
|
| 2016 |
Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, et al. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science (New York, N.Y.). 351: 1450-4. PMID 27013732 DOI: 10.1126/Science.Aad2257 |
0.565 |
|
| 2015 |
Siggers T, Gilmore TD, Barron B, Penvose A. Characterizing the DNA binding site specificity of NF-κB with protein-binding microarrays (PBMs). Methods in Molecular Biology (Clifton, N.J.). 1280: 609-30. PMID 25736775 DOI: 10.1007/978-1-4939-2422-6_36 |
0.584 |
|
| 2015 |
Andrilenas KK, Penvose A, Siggers T. Using protein-binding microarrays to study transcription factor specificity: homologs, isoforms and complexes. Briefings in Functional Genomics. 14: 17-29. PMID 25431149 DOI: 10.1093/Bfgp/Elu046 |
0.574 |
|
| 2014 |
Siggers T, Reddy J, Barron B, Bulyk ML. Diversification of transcription factor paralogs via noncanonical modularity in C2H2 zinc finger DNA binding. Molecular Cell. 55: 640-8. PMID 25042805 DOI: 10.1016/J.Molcel.2014.06.019 |
0.596 |
|
| 2014 |
Siggers T, Gordân R. Protein–DNA binding: complexities and multi-protein codes Nucleic Acids Research. 42: 2099-2111. PMID 24243859 DOI: 10.1093/Nar/Gkt1112 |
0.523 |
|
| 2013 |
Soruco MM, Chery J, Bishop EP, Siggers T, Tolstorukov MY, Leydon AR, Sugden AU, Goebel K, Feng J, Xia P, Vedenko A, Bulyk ML, Park PJ, Larschan E. The CLAMP protein links the MSL complex to the X chromosome during Drosophila dosage compensation. Genes & Development. 27: 1551-6. PMID 23873939 DOI: 10.1101/Gad.214585.113 |
0.405 |
|
| 2011 |
Siggers T, Duyzend MH, Reddy J, Khan S, Bulyk ML. Non-DNA-binding cofactors enhance DNA-binding specificity of a transcriptional regulatory complex. Molecular Systems Biology. 7: 555. PMID 22146299 DOI: 10.1038/Msb.2011.89 |
0.601 |
|
| 2011 |
Siggers T, Chang AB, Teixeira A, Wong D, Williams KJ, Ahmed B, Ragoussis J, Udalova IA, Smale ST, Bulyk ML. Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-κB family DNA binding. Nature Immunology. 13: 95-102. PMID 22101729 DOI: 10.1038/Ni.2151 |
0.552 |
|
| 2011 |
Wong D, Teixeira A, Oikonomopoulos S, Humburg P, Lone IN, Saliba D, Siggers T, Bulyk M, Angelov D, Dimitrov S, Udalova IA, Ragoussis J. Extensive characterization of NF-κB binding uncovers non-canonical motifs and advances the interpretation of genetic functional traits Genome Biology. 12. PMID 21801342 DOI: 10.1186/Gb-2011-12-7-R70 |
0.585 |
|
| 2010 |
Rowan S, Siggers T, Lachke SA, Yue Y, Bulyk ML, Maas RL. Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity. Genes & Development. 24: 980-5. PMID 20413611 DOI: 10.1101/Gad.1890410 |
0.541 |
|
| 2010 |
Giorgetti L, Siggers T, Tiana G, Caprara G, Notarbartolo S, Corona T, Pasparakis M, Milani P, Bulyk ML, Natoli G. Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputs. Molecular Cell. 37: 418-28. PMID 20159560 DOI: 10.1016/J.Molcel.2010.01.016 |
0.519 |
|
| 2009 |
Viiri KM, Jänis J, Siggers T, Heinonen TY, Valjakka J, Bulyk ML, Mäki M, Lohi O. DNA-binding and -bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositides. Molecular and Cellular Biology. 29: 342-56. PMID 19015240 DOI: 10.1128/Mcb.01213-08 |
0.541 |
|
| 2009 |
McCord RP, Zhu C, Siggers TW, Bulyk ML. Linking Yeast Transcription Factor Structural Class and Detailed Binding Preferences with in vivo Regulatory Functions Biophysical Journal. 96: 62a. DOI: 10.1016/J.Bpj.2008.12.218 |
0.556 |
|
| 2009 |
Giorgetti L, Siggers T, Yaeger S, Tiana G, Caprara G, Milani P, Bulyk ML, Natoli G. A Graded Response of a Transcription Factor to Increasing Doses of External Stimuli: A Thermodynamic Framework Describing the Behavior of NF-kB Biophysical Journal. 96: 304a-305a. DOI: 10.1016/J.Bpj.2008.12.1517 |
0.514 |
|
| 2007 |
Siggers TW, Honig B. Structure-based prediction of C2H2 zinc-finger binding specificity: sensitivity to docking geometry. Nucleic Acids Research. 35: 1085-97. PMID 17264128 DOI: 10.1093/Nar/Gkl1155 |
0.549 |
|
| 2005 |
Siggers T, Silkov T, Honig B. Bending in the right direction Structure. 13: 1400-1401. PMID 16216570 DOI: 10.1016/J.Str.2005.09.002 |
0.563 |
|
| 2005 |
Siggers TW, Silkov A, Honig B. Structural alignment of protein--DNA interfaces: insights into the determinants of binding specificity. Journal of Molecular Biology. 345: 1027-45. PMID 15644202 DOI: 10.1016/J.Jmb.2004.11.010 |
0.518 |
|
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