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Tyler A. Johnson, Ph.D. - Publications

Affiliations: 
University of California, Santa Cruz, Santa Cruz, CA, United States 
Area:
chemistry of tropical marine sponges and marine-derived fungi
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32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Dutta N, Gerke JA, Odron SF, Morris JD, Hruby A, Torres TC, Shemtov SJ, Clarke JG, Chang MC, Shaghasi H, Ray MN, Averbukh M, Hoang S, Oorloff M, Alcala A, ... ... Johnson TA, et al. Investigating impacts of marine sponge derived mycothiazole and its acetylated derivative on mitochondrial function and aging. Biorxiv : the Preprint Server For Biology. PMID 38077060 DOI: 10.1101/2023.11.27.568896  0.482
2022 Takahashi-Ruiz L, Morris JD, Crews P, Johnson TA, Risinger AL. In Vivo Evaluation of (-)-Zampanolide Demonstrates Potent and Persistent Antitumor Efficacy When Targeted to the Tumor Site. Molecules (Basel, Switzerland). 27. PMID 35807495 DOI: 10.3390/molecules27134244  0.517
2022 Morris JD, Takahashi-Ruiz L, Persi LN, Summers JC, McCauley EP, Chan PYW, Amberchan G, Lizama-Chamu I, Coppage DA, Crews P, Risinger AL, Johnson TA. Re-evaluation of the Fijianolide/Laulimalide Chemotype Suggests an Alternate Mechanism of Action for C-15/C-20 Analogs. Acs Omega. 7: 8824-8832. PMID 35309480 DOI: 10.1021/acsomega.1c07146  0.54
2020 Johnson TA, Morris JD, Coppage DA, Cook CV, Persi LN, Ogarrio MA, Garcia TC, McIntosh NL, McCauley EP, Media J, Maheshwari M, Valeriote FA, Shaw J, Crews P. Reinvestigation of Mycothiazole Reveals the Penta-2,4-dien-1-ol Residue Imparts Picomolar Potency and 8 Configuration. Acs Medicinal Chemistry Letters. 11: 108-113. PMID 32071675 DOI: 10.1021/Acsmedchemlett.9B00302  0.575
2018 McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, ... ... Johnson TA, et al. Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports. PMID 30468235 DOI: 10.1039/c8np90041h  0.454
2018 McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, ... ... Johnson TA, et al. The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural Product Reports. PMID 30003207 DOI: 10.1039/C7Np00064B  0.514
2018 Lorig-Roach N, Hamkins-Indik F, Johnson TA, Tenney K, Valeriote FA, Crews P. The potential of achiral sponge-derived and synthetic bromoindoles as selective cytotoxins against PANC-1 tumor cells. Tetrahedron. 74: 217-223. PMID 29576661 DOI: 10.1016/J.Tet.2017.11.029  0.632
2017 Lin S, McCauley EP, Lorig-Roach N, Tenney K, Naphen CN, Yang AM, Johnson TA, Hernadez T, Rattan R, Valeriote FA, Crews P. Another Look at Pyrroloiminoquinone Alkaloids-Perspectives on Their Therapeutic Potential from Known Structures and Semisynthetic Analogues. Marine Drugs. 15. PMID 28353633 DOI: 10.3390/Md15040098  0.64
2016 Johnson TA, Milan-Lobo L, Che T, Ferwerda M, Lambo E, McIntosh NL, Li F, He L, Lorig-Roach N, Crews P, Whistler JL. Identification of the first marine-derived opioid receptor "balanced" agonist with a signaling profile that resembles the endorphins. Acs Chemical Neuroscience. PMID 27744679 DOI: 10.1021/Acschemneuro.6B00167  0.559
2015 Theodore CM, Lorig-Roach N, Still PC, Johnson TA, Draškovi? M, Schwochert JA, Naphen CN, Crews MS, Barker SA, Valeriote FA, Lokey RS, Crews P. Biosynthetic products from a nearshore-derived gram-negative bacterium enable reassessment of the kailuin depsipeptides. Journal of Natural Products. 78: 441-52. PMID 25699470 DOI: 10.1021/Np500840N  0.744
2014 Still PC, Johnson TA, Theodore CM, Loveridge ST, Crews P. Scrutinizing the scaffolds of marine biosynthetics from different source organisms: Gram-negative cultured bacterial products enter center stage. Journal of Natural Products. 77: 690-702. PMID 24571234 DOI: 10.1021/Np500041X  0.726
2013 Johnson TA, Sohn J, Ward AE, Cohen TL, Lorig-Roach ND, Chen H, Pilli RA, Widjaja EA, Hanafi M, Kardono LB, Lotulung PD, Boundy-Mills K, Bjeldanes LF. (+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines. Bioorganic & Medicinal Chemistry. 21: 4358-64. PMID 23735825 DOI: 10.1016/J.Bmc.2013.04.055  0.353
2013 Rohena CC, Peng J, Johnson TA, Crews P, Mooberry SL. Chemically diverse microtubule stabilizing agents initiate distinct mitotic defects and dysregulated expression of key mitotic kinases. Biochemical Pharmacology. 85: 1104-14. PMID 23399639 DOI: 10.1016/J.Bcp.2013.01.030  0.516
2013 Johnson TA, Sohn J, Inman WD, Bjeldanes LF, Rayburn K. Lipophilic stinging nettle extracts possess potent anti-inflammatory activity, are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 20: 143-7. PMID 23092723 DOI: 10.1016/J.Phymed.2012.09.016  0.32
2013 Rohena CC, Peng J, Johnson TA, Crews P, Mooberry SL. Abstract 4501: Diverse microtubule stabilizers cause differential expression of mitotic kinases leading to distinct centrosomal and mitotic defects. Cancer Research. 73: 4501-4501. DOI: 10.1158/1538-7445.Am2013-4501  0.498
2012 Valeriote FA, Tenney K, Media J, Pietraszkiewicz H, Edelstein M, Johnson TA, Amagata T, Crews P. Discovery and development of anticancer agents from marine sponges: perspectives based on a chemistry-experimental therapeutics collaborative program. Journal of Experimental Therapeutics & Oncology. 10: 119-34. PMID 23350352  0.61
2012 Johnson TA, Sohn J, Vaske YM, White KN, Cohen TL, Vervoort HC, Tenney K, Valeriote FA, Bjeldanes LF, Crews P. Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries. Bioorganic & Medicinal Chemistry. 20: 4348-55. PMID 22705020 DOI: 10.1016/J.Bmc.2012.05.043  0.599
2011 Johnson TA, Sohn J, Inman WD, Estee SA, Loveridge ST, Vervoort HC, Tenney K, Liu J, Ang KK, Ratnam J, Bray WM, Gassner NC, Shen YY, Lokey RS, McKerrow JH, et al. Natural product libraries to accelerate the high-throughput discovery of therapeutic leads. Journal of Natural Products. 74: 2545-55. PMID 22129061 DOI: 10.1021/Np200673B  0.665
2010 Wu QX, Crews MS, Draskovic M, Sohn J, Johnson TA, Tenney K, Valeriote FA, Yao XJ, Bjeldanes LF, Crews P. Azonazine, a novel dipeptide from a Hawaiian marine sediment-derived fungus, Aspergillus insulicola. Organic Letters. 12: 4458-61. PMID 20866076 DOI: 10.1021/Ol101396N  0.55
2010 Morgan JB, Mahdi F, Liu Y, Coothankandaswamy V, Jekabsons MB, Johnson TA, Sashidhara KV, Crews P, Nagle DG, Zhou YD. The marine sponge metabolite mycothiazole: a novel prototype mitochondrial complex I inhibitor. Bioorganic & Medicinal Chemistry. 18: 5988-94. PMID 20637638 DOI: 10.1016/J.Bmc.2010.06.072  0.63
2010 Shaw J, Valeriote FA, Media J, Johnson TA, Amagata T, Tenney K, Crews P. Development and validation of a rapid method for the detection of latrunculol A in plasma. Analytical and Bioanalytical Chemistry. 396: 1741-4. PMID 20043220 DOI: 10.1007/S00216-009-3385-5  0.502
2010 Johnson TA, Morgan MV, Aratow NA, Estee SA, Sashidhara KV, Loveridge ST, Segraves NL, Crews P. Assessing pressurized liquid extraction for the high-throughput extraction of marine-sponge-derived natural products. Journal of Natural Products. 73: 359-64. PMID 20030364 DOI: 10.1021/Np900565A  0.543
2009 Johnson TA, Amagata T, Sashidhara KV, Oliver AG, Tenney K, Matainaho T, Ang KK, McKerrow JH, Crews P. The aignopsanes, a new class of sesquiterpenes from selected chemotypes of the sponge Cacospongia mycofijiensis. Organic Letters. 11: 1975-8. PMID 19385671 DOI: 10.1021/Ol900446D  0.549
2008 Amagata T, Johnson TA, Cichewicz RH, Tenney K, Mooberry SL, Media J, Edelstein M, Valeriote FA, Crews P. Interrogating the bioactive pharmacophore of the latrunculin chemotype by investigating the metabolites of two taxonomically unrelated sponges. Journal of Medicinal Chemistry. 51: 7234-42. PMID 18942825 DOI: 10.1021/Jm8008585  0.61
2008 Johnson TA, Amagata T, Oliver AG, Tenney K, Valeriote FA, Crews P. The unexpected isolation of CTP-431, a novel thiopyrone from the sponge Cacospongia mycofijiensis. The Journal of Organic Chemistry. 73: 7255-9. PMID 18715038 DOI: 10.1021/Jo801096M  0.567
2007 Deschamps JD, Gautschi JT, Whitman S, Johnson TA, Gassner NC, Crews P, Holman TR. Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorganic & Medicinal Chemistry. 15: 6900-8. PMID 17826100 DOI: 10.1016/J.Bmc.2007.08.015  0.586
2007 Johnson TA, Tenney K, Cichewicz RH, Morinaka BI, White KN, Amagata T, Subramanian B, Media J, Mooberry SL, Valeriote FA, Crews P. Sponge-derived fijianolide polyketide class: further evaluation of their structural and cytotoxicity properties. Journal of Medicinal Chemistry. 50: 3795-803. PMID 17622130 DOI: 10.1021/Jm070410Z  0.646
2006 Sonnenschein RN, Johnson TA, Tenney K, Valeriote FA, Crews P. A reassignment of (-)-mycothiazole and the isolation of a related diol. Journal of Natural Products. 69: 145-7. PMID 16441088 DOI: 10.1021/Np0503597  0.633
2004 Segraves EN, Shah RR, Segraves NL, Johnson TA, Whitman S, Sui JK, Kenyon VA, Cichewicz RH, Crews P, Holman TR. Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. Journal of Medicinal Chemistry. 47: 4060-5. PMID 15267244 DOI: 10.1021/Jm049872S  0.606
2003 Amagata T, Whitman S, Johnson TA, Stessman CC, Loo CP, Lobkovsky E, Clardy J, Crews P, Holman TR. Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases Journal of Natural Products. 66: 230-235. PMID 12608855 DOI: 10.1021/Np020462L  0.615
2003 Segraves NL, Lopez S, Johnson TA, Said SA, Fu X, Schmitz FJ, Pietraszkiewicz H, Valeriote FA, Crews P. Structures and cytotoxicities of fascaplysin and related alkaloids from two marine phyla - Fascaplysinopsis sponges and Didemnum tunicates Tetrahedron Letters. 44: 3471-3475. DOI: 10.1016/S0040-4039(03)00671-3  0.678
2002 Thale Z, Johnson T, Tenney K, Wenzel PJ, Lobkovsky E, Clardy J, Media J, Pietraszkiewicz H, Valeriote FA, Crews P. Structures and cytotoxic properties of sponge-derived bisannulated acridines. The Journal of Organic Chemistry. 67: 9384-91. PMID 12492342 DOI: 10.1021/Jo026459O  0.747
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