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Kevin J. Frankowski, Ph.D. - Publications

Affiliations: 
University of Delaware, Newark, DE, United States 
Area:
Stereoselective synthesis of natural products; New methods in synthetic organic chemistry; Computational organometa llic chemistry
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Moritz AE, Free RB, Weiner WS, Akano EO, Gandhi D, Abramyan A, Keck TM, Ferrer M, Hu X, Southall N, Steiner J, Aubé J, Shi L, Frankowski KJ, Sibley DR. Discovery, Optimization and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist. Journal of Medicinal Chemistry. PMID 32342685 DOI: 10.1021/Acs.Jmedchem.0C00424  0.344
2018 Luderman KD, Conroy JL, Free RB, Southall N, Ferrer M, Sanchez-Soto M, Moritz AE, Willette BKA, Fyfe TJ, Jain P, Titus S, Hazelwood LA, Aube J, Lane JR, Frankowski KJ, et al. Identification of positive allosteric modulators of the D1 dopamine receptor that act at diverse binding sites. Molecular Pharmacology. PMID 30068735 DOI: 10.1124/Mol.118.113175  0.345
2018 Chun LS, Vekariya RH, Free RB, Li Y, Lin DT, Su P, Liu F, Namkung Y, Laporte SA, Moritz AE, Aubé J, Frankowski KJ, Sibley DR. Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the DDopamine Receptor. Frontiers in Synaptic Neuroscience. 10: 2. PMID 29515433 DOI: 10.3389/Fnsyn.2018.00002  0.339
2016 McLeod MC, Aubé J, Frankowski KJ. Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples. Bioorganic & Medicinal Chemistry Letters. PMID 27839919 DOI: 10.1016/J.Bmcl.2016.10.065  0.344
2016 Scarry SM, Lovell KM, Frankowski KJ, Bohn LM, Aubé J. Synthesis of Kappa Opioid Antagonists Based On Pyrrolo[1,2-alpha]quinoxalinones Using an N-Arylation/Condensation/Oxidation Reaction Sequence. The Journal of Organic Chemistry. PMID 27399050 DOI: 10.1021/Acs.Joc.6B01350  0.322
2016 Luderman KD, Conroy JL, Free RB, Southall NT, Ferrer M, Aubé J, Frankowski KJ, Sibley DR. Structurally Diverse Positive Allosteric Modulators of the D1 Dopamine Receptor Potentiate G‐Protein and β‐Arrestin‐Mediated Signaling The Faseb Journal. 30. DOI: 10.1096/Fasebj.30.1_Supplement.931.9  0.321
2015 He S, Jain P, Lin B, Ferrer M, Hu Z, Southall N, Hu X, Zheng W, Neuenswander B, Cho CH, Chen Y, Worlikar SA, Aubé J, Larock RC, Schoenen FJ, ... ... Frankowski KJ, et al. High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors. Acs Combinatorial Science. PMID 26332742 DOI: 10.1021/Acscombsci.5B00101  0.342
2015 Morgenweck J, Frankowski KJ, Prisinzano TE, Aubé J, Bohn LM. Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus. Neuropharmacology. PMID 26318102 DOI: 10.1016/J.Neuropharm.2015.08.027  0.31
2015 Zhou L, Stahl EL, Lovell KM, Frankowski KJ, Prisinzano TE, Aubé J, Bohn LM. Characterization of kappa opioid receptor mediated, dynorphin-stimulated [(35)S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting. Neuropharmacology. PMID 26160155 DOI: 10.1016/J.Neuropharm.2015.07.001  0.345
2015 Sweeney NL, Hanson AM, Mukherjee S, Ndjomou J, Geiss BJ, Steel JJ, Frankowski KJ, Li K, Schoenen FJ, Frick DN. Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase. Acs Infectious Diseases. 1: 140-148. PMID 26029739 DOI: 10.1021/Id5000458  0.318
2015 Lovell KM, Frankowski KJ, Stahl EL, Slauson SR, Yoo E, Prisinzano TE, Aubé J, Bohn LM. Structure-Activity Relationship Studies of Functionally Selective Kappa Opioid Receptor Agonists that Modulate ERK 1/2 Phosphorylation While Preserving G Protein Over βArrestin2 Signaling Bias. Acs Chemical Neuroscience. PMID 25891774 DOI: 10.1021/Acschemneuro.5B00092  0.333
2015 Frankowski KJ, Slauson SR, Lovell KM, Phillips AM, Streicher JM, Zhou L, Whipple DA, Schoenen FJ, Prisinzano TE, Bohn LM, Aubé J. Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif. Bioorganic & Medicinal Chemistry. 23: 3948-56. PMID 25593096 DOI: 10.1016/J.Bmc.2014.12.033  0.35
2013 Zhou L, Lovell KM, Frankowski KJ, Slauson SR, Phillips AM, Streicher JM, Stahl E, Schmid CL, Hodder P, Madoux F, Cameron MD, Prisinzano TE, Aubé J, Bohn LM. Development of functionally selective, small molecule agonists at kappa opioid receptors. The Journal of Biological Chemistry. 288: 36703-16. PMID 24187130 DOI: 10.1074/Jbc.M113.504381  0.352
2013 Vardy E, Mosier PD, Frankowski KJ, Wu H, Katritch V, Westkaemper RB, Aubé J, Stevens RC, Roth BL. Chemotype-selective modes of action of κ-opioid receptor agonists. The Journal of Biological Chemistry. 288: 34470-83. PMID 24121503 DOI: 10.1074/Jbc.M113.515668  0.31
2013 Sweeney NL, Shadrick WR, Mukherjee S, Li K, Frankowski KJ, Schoenen FJ, Frick DN. Primuline derivatives that mimic RNA to stimulate hepatitis C virus NS3 helicase-catalyzed ATP hydrolysis. The Journal of Biological Chemistry. 288: 19949-57. PMID 23703611 DOI: 10.1074/Jbc.M113.463166  0.305
2012 Ndjomou J, Kolli R, Mukherjee S, Shadrick WR, Hanson AM, Sweeney NL, Bartczak D, Li K, Frankowski KJ, Schoenen FJ, Frick DN. Fluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation. Antiviral Research. 96: 245-55. PMID 22940425 DOI: 10.1016/J.Antiviral.2012.08.006  0.306
2012 Frankowski KJ, Hedrick MP, Gosalia P, Li K, Shi S, Whipple D, Ghosh P, Prisinzano TE, Schoenen FJ, Su Y, Vasile S, Sergienko E, Gray W, Hariharan S, Milan L, et al. Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. Acs Chemical Neuroscience. 3: 221-236. PMID 22737280 DOI: 10.1021/Cn200128X  0.334
2012 Li K, Frankowski KJ, Belon CA, Neuenswander B, Ndjomou J, Hanson AM, Shanahan MA, Schoenen FJ, Blagg BS, Aubé J, Frick DN. Optimization of potent hepatitis C virus NS3 helicase inhibitors isolated from the yellow dyes thioflavine S and primuline. Journal of Medicinal Chemistry. 55: 3319-30. PMID 22409723 DOI: 10.1021/Jm300021V  0.312
2012 Frankowski KJ, Setola V, Evans JM, Neuenswander B, Roth BL, Aubé J. Synthesis and receptor profiling of Stemona alkaloid analogues reveal a potent class of sigma ligands (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 17, (6727-6732) DOI: 10.1073/pnas.1016558108) Proceedings of the National Academy of Sciences of the United States of America. 109: 15526-15527. DOI: 10.1073/Pnas.1213952109  0.302
2011 Frankowski KJ, Setola V, Evans JM, Neuenswander B, Roth BL, Aubé J. Synthesis and receptor profiling of Stemona alkaloid analogues reveal a potent class of sigma ligands. Proceedings of the National Academy of Sciences of the United States of America. 108: 6727-32. PMID 21368188 DOI: 10.1073/Pnas.1016558108  0.382
2010 Frankowski KJ, Ghosh P, Setola V, Tran TB, Roth BL, Aubé J. N-Alkyl-octahydroisoquinolin-1-one-8-carboxamides: a Novel Class of Selective, Nonbasic, Nitrogen-Containing κ-Opioid Receptor Ligands. Acs Medicinal Chemistry Letters. 1: 189-193. PMID 20729985 DOI: 10.1021/Ml100040T  0.348
2008 Frankowski KJ, Neuenswander B, Aubé J. Explorations of stemona alkaloid-inspired analogues: skeletal modification and functional group diversification. Journal of Combinatorial Chemistry. 10: 721-5. PMID 18698827 DOI: 10.1021/Cc800078H  0.341
2008 Nöth J, Frankowski KJ, Neuenswander B, Aubé J, Reiser O. Efficient synthesis of gamma-lactams by a tandem reductive amination/lactamization sequence. Journal of Combinatorial Chemistry. 10: 456-9. PMID 18338857 DOI: 10.1021/Cc700202C  0.307
2008 Taber DF, Sikkander MI, Berry JF, Frankowski KJ. Preparation of 2-iodo allylic alcohols from 2-butyn-1,4-diol Journal of Organic Chemistry. 73: 1605-1607. PMID 18197678 DOI: 10.1021/Jo7021197  0.552
2008 Frankowski KJ, Wrobleski A, Aubé J. Chapter 12 The total synthesis of amphibian alkaloids using the intramolecular schmidt reaction Strategies and Tactics in Organic Synthesis. 7: 408-459. DOI: 10.1016/S1874-6004(08)80016-0  0.314
2007 Frankowski KJ, Hirt EE, Zeng Y, Neuenswander B, Fowler D, Schoenen F, Aubé J. Synthesis of N-alkyl-octahydroisoquinolin-1-one-8-carboxamide libraries using a tandem Diels-Alder/acylation sequence. Journal of Combinatorial Chemistry. 9: 1188-92. PMID 17896822 DOI: 10.1021/Cc700127F  0.323
2006 Taber DF, Frankowski KJ. Grubbs's cross metathesis of eugenol with cis-2-butene-1,4-diol to make a natural product. An organometallic experiment for the undergraduate lab Journal of Chemical Education. 83: 283-284. DOI: 10.1021/Ed083P283  0.468
2005 Taber DF, Frankowski KJ. Synthesis of (+)-sulcatine G Journal of Organic Chemistry. 70: 6417-6421. PMID 16050704 DOI: 10.1021/Jo0508752  0.479
2003 Taber DF, Frankowski KJ. Grubbs' catalyst in paraffin: An air-stable preparation for alkene metathesis Journal of Organic Chemistry. 68: 6047-6048. PMID 12868947 DOI: 10.1021/Jo030005P  0.468
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