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Jeffrey M. Spraggins, Ph.D. - Publications

Affiliations: 
Chemistry and Biochemistry University of Delaware, Newark, DE, United States 
Area:
FT-ICR
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60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Djambazova KV, van Ardenne JM, Spraggins JM. Advances in Imaging Mass Spectrometry for Biomedical and Clinical Research. Trends in Analytical Chemistry : Trac. 169. PMID 38045023 DOI: 10.1016/j.trac.2023.117344  0.351
2023 Esselman AB, Patterson NH, Migas LG, Dufresne M, Djambazova KV, Colley ME, Van de Plas R, Spraggins JM. Microscopy-Directed Imaging Mass Spectrometry for Rapid High Spatial Resolution Molecular Imaging of Glomeruli. Journal of the American Society For Mass Spectrometry. 34: 1305-1314. PMID 37319264 DOI: 10.1021/jasms.3c00033  0.382
2023 Sharman K, Patterson NH, Migas LG, Neumann EK, Allen J, Gibson-Corley KN, Spraggins JM, Van de Plas R, Skaar EP, Caprioli RM. MALDI IMS-Derived Molecular Contour Maps: Augmenting Histology Whole-Slide Images. Journal of the American Society For Mass Spectrometry. PMID 37061946 DOI: 10.1021/jasms.2c00370  0.334
2022 Djambazova KV, Dufresne M, Migas LG, Kruse ARS, Van de Plas R, Caprioli RM, Spraggins JM. MALDI TIMS IMS of Disialoganglioside Isomers─GD1a and GD1b in Murine Brain Tissue. Analytical Chemistry. 95: 1176-1183. PMID 36574465 DOI: 10.1021/acs.analchem.2c03939  0.308
2022 Su P, McGee JP, Durbin KR, Hollas MAR, Yang M, Neumann EK, Allen JL, Drown BS, Butun FA, Greer JB, Early BP, Fellers RT, Spraggins JM, Laskin J, Camarillo JM, et al. Highly multiplexed, label-free proteoform imaging of tissues by individual ion mass spectrometry. Science Advances. 8: eabp9929. PMID 35947651 DOI: 10.1126/sciadv.abp9929  0.415
2022 Perry WJ, Grunenwald CM, Van de Plas R, Witten JC, Martin DR, Apte SS, Cassat JE, Pettersson GB, Caprioli RM, Skaar EP, Spraggins JM. Visualizing Staphylococcus aureus pathogenic membrane modification within the host infection environment by multimodal imaging mass spectrometry. Cell Chemical Biology. PMID 35654040 DOI: 10.1016/j.chembiol.2022.05.004  0.301
2022 Guiberson ER, Good CJ, Wexler AG, Skaar EP, Spraggins JM, Caprioli RM. Multimodal Imaging Mass Spectrometry of Murine Gastrointestinal Tract with Retained Luminal Content. Journal of the American Society For Mass Spectrometry. PMID 35545232 DOI: 10.1021/jasms.1c00360  0.36
2022 Richardson LT, Neumann EK, Caprioli RM, Spraggins JM, Solouki T. Referenced Kendrick Mass Defect Annotation and Class-Based Filtering of Imaging MS Lipidomics Experiments. Analytical Chemistry. 94: 5504-5513. PMID 35344335 DOI: 10.1021/acs.analchem.1c03715  0.357
2022 Kruse ARS, Spraggins JM. Uncovering Molecular Heterogeneity in the Kidney With Spatially Targeted Mass Spectrometry. Frontiers in Physiology. 13: 837773. PMID 35222094 DOI: 10.3389/fphys.2022.837773  0.363
2021 Fincher JA, Djambazova KV, Klein DR, Dufresne M, Migas LG, Van de Plas R, Caprioli RM, Spraggins JM. Molecular Mapping of Neutral Lipids Using Silicon Nanopost Arrays and TIMS Imaging Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 34435768 DOI: 10.1021/jasms.1c00159  0.393
2021 Neumann EK, Patterson NH, Allen JL, Migas LG, Yang H, Brewer M, Anderson DM, Harvey J, Gutierrez DB, Harris RC, deCaestecker MP, Fogo AB, Van de Plas R, Caprioli RM, Spraggins JM. Protocol for multimodal analysis of human kidney tissue by imaging mass spectrometry and CODEX multiplexed immunofluorescence. Star Protocols. 2: 100747. PMID 34430920 DOI: 10.1016/j.xpro.2021.100747  0.319
2020 Li L, Laskin J, Spraggins J. 35th ASMS Asilomar Conference on Mass Spectrometry. Mass Spectrometry Imaging: New Developments and Applications. Journal of the American Society For Mass Spectrometry. 31: 2390-2391. PMID 33595332 DOI: 10.1021/jasms.0c00404  0.309
2020 McMillen JC, Fincher JA, Klein DR, Spraggins JM, Caprioli RM. Effect of MALDI matrices on lipid analyses of biological tissues using MALDI-2 postionization mass spectrometry. Journal of Mass Spectrometry : Jms. 55: e4663. PMID 33241625 DOI: 10.1002/jms.4663  0.326
2020 Rivera ES, Djambazova KV, Neumann EK, Caprioli RM, Spraggins JM. Integrating ion mobility and imaging mass spectrometry for comprehensive analysis of biological tissues: A brief review and perspective. Journal of Mass Spectrometry : Jms. e4614. PMID 32955134 DOI: 10.1002/Jms.4614  0.465
2020 Neumann EK, Djambazova KV, Caprioli RM, Spraggins JM. Multimodal Imaging Mass Spectrometry: Next Generation Molecular Mapping in Biology and Medicine. Journal of the American Society For Mass Spectrometry. PMID 32886506 DOI: 10.1021/Jasms.0C00232  0.454
2020 Prentice BM, Ryan DJ, Grove KJ, Cornett DS, Caprioli RM, Spraggins JM. Dynamic range expansion by gas-phase ion fractionation and enrichment for imaging mass spectrometry. Analytical Chemistry. PMID 32845133 DOI: 10.1021/Acs.Analchem.0C02121  0.411
2020 Djambazova K, Klein DR, Migas LG, Neumann EK, Rivera ES, Van de Plas R, Caprioli RM, Spraggins JM. Resolving the Complexity of Spatial Lipidomics Using MALDI TIMS Imaging Mass Spectrometry. Analytical Chemistry. PMID 32808523 DOI: 10.1021/Acs.Analchem.0C02520  0.491
2020 Neumann EK, Migas LG, Allen JL, Caprioli RM, Van de Plas R, Spraggins JM. Spatial Metabolomics of the Human Kidney using MALDI Trapped Ion Mobility Imaging Mass Spectrometry. Analytical Chemistry. PMID 32668145 DOI: 10.1021/Acs.Analchem.0C02051  0.432
2020 Anderson DM, Messinger JD, Patterson NH, Rivera ES, Kotnala A, Spraggins JM, Caprioli RM, Curcio C, Schey KL. Lipid Landscape of the Human Retina and Supporting Tissues Revealed by High Resolution Imaging Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 32628476 DOI: 10.1021/Jasms.0C00119  0.426
2020 Jones MA, Cho SH, Patterson NH, Van de Plas R, Spraggins JM, Boothby MR, Caprioli RM. Discovering new lipidomic features using cell type specific fluorophore expression to provide spatial and biological specificity in a multimodal workflow with MALDI Imaging Mass Spectrometry. Analytical Chemistry. PMID 32298091 DOI: 10.1021/Acs.Analchem.0C00446  0.453
2020 Perry WJ, Weiss A, Van de Plas R, Spraggins JM, Caprioli RM, Skaar EP. Integrated molecular imaging technologies for investigation of metals in biological systems: A brief review. Current Opinion in Chemical Biology. 55: 127-135. PMID 32087551 DOI: 10.1016/J.Cbpa.2020.01.008  0.383
2019 Spraggins JM, Schwamborn K, Heeren RMA, Eberlin LS. The Importance of Clinical Tissue Imaging. Clinical Mass Spectrometry (Del Mar, Calif.). 12: 47-49. PMID 32483555 DOI: 10.1016/J.Clinms.2019.04.001  0.36
2019 Perry WJ, Patterson NH, Prentice BM, Neumann EK, Caprioli RM, Spraggins JM. Uncovering Matrix Effects on Lipid Analyses in MALDI Imaging Mass Spectrometry Experiments. Journal of Mass Spectrometry : Jms. e4491. PMID 31860760 DOI: 10.1002/Jms.4491  0.415
2019 Perry WJ, Spraggins JM, Sheldon JR, Grunenwald CM, Heinrichs DE, Cassat JE, Skaar EP, Caprioli RM. exhibits heterogeneous siderophore production within the vertebrate host. Proceedings of the National Academy of Sciences of the United States of America. PMID 31611408 DOI: 10.1073/Pnas.1913991116  0.3
2019 Spraggins JM, Djambazova KV, Rivera ES, Migas L, Neumann EK, Fuetterer A, Suetering J, Goedecke N, Ly A, Van de Plas R, Caprioli RM. High Performance Molecular Imaging with MALDI Trapped Ion Mobility Time-of-Flight (timsTOF) Mass Spectrometry. Analytical Chemistry. PMID 31593446 DOI: 10.1021/Acs.Analchem.9B03612  0.498
2019 Ryan DJ, Patterson NH, Putnam NE, Wilde AD, Weiss A, Perry WJ, Cassat JE, Skaar EP, Caprioli RM, Spraggins JM. MicroLESA: Integrating Autofluorescence Microscopy, In Situ Micro-Digestions, and Liquid Extraction Surface Analysis for High Spatial Resolution Targeted Proteomic Studies. Analytical Chemistry. PMID 31149808 DOI: 10.1021/Acs.Analchem.8B05889  0.366
2019 Prentice BM, Hart NJ, Phillips N, Haliyur R, Judd A, Armandala R, Spraggins JM, Lowe CL, Boyd KL, Stein RW, Wright CV, Norris JL, Powers AC, Brissova M, Caprioli RM. Imaging mass spectrometry enables molecular profiling of mouse and human pancreatic tissue. Diabetologia. PMID 30955045 DOI: 10.1007/S00125-019-4855-8  0.444
2019 Spivey EC, McMillen JC, Ryan DJ, Spraggins JM, Caprioli RM. Combining MALDI-2 and Transmission Geometry Laser Optics to Achieve High Sensitivity for Ultra-High Spatial Resolution Surface Analysis. Journal of Mass Spectrometry : Jms. PMID 30675932 DOI: 10.1002/Jms.4335  0.349
2019 Spraggins JM, Siegel TP. Biomedical imaging by high performance mass spectrometry International Journal of Mass Spectrometry. 437: 1-2. DOI: 10.1016/J.Ijms.2018.11.018  0.434
2018 Ryan DJ, Spraggins JM, Caprioli RM. Protein identification strategies in MALDI imaging mass spectrometry: a brief review. Current Opinion in Chemical Biology. 48: 64-72. PMID 30476689 DOI: 10.1016/J.Cbpa.2018.10.023  0.447
2018 Cressman ENK, Spraggins JM. Viewing the Future of IR through Molecular Histology: An Overview of Imaging Mass Spectrometry. Journal of Vascular and Interventional Radiology : Jvir. PMID 30274858 DOI: 10.1016/J.Jvir.2018.07.004  0.442
2018 Kleinridders A, Ferris HA, Reyzer ML, Rath M, Soto M, Manier ML, Spraggins J, Yang Z, Stanton RC, Caprioli RM, Kahn CR. Regional differences in brain glucose metabolism determined by imaging mass spectrometry. Molecular Metabolism. PMID 29681509 DOI: 10.1016/J.Molmet.2018.03.013  0.303
2018 Cassat JE, Moore JL, Wilson KJ, Stark Z, Prentice BM, Van de Plas R, Perry WJ, Zhang Y, Virostko J, Colvin DC, Rose KL, Judd AM, Reyzer ML, Spraggins JM, Grunenwald CM, et al. Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions. Science Translational Medicine. 10. PMID 29540616 DOI: 10.1126/Scitranslmed.Aan6361  0.392
2018 Prentice BM, Ryan D, Van de Plas R, Caprioli RM, Spraggins JM. Enhanced Ion Transmission Efficiency up to m/z 24,000 for MALDI Protein Imaging Mass Spectrometry. Analytical Chemistry. PMID 29444410 DOI: 10.1021/Acs.Analchem.7B05105  0.423
2017 Anderson DMG, Ablonczy Z, Koutalos Y, Hanneken AM, Spraggins JM, Calcutt MW, Crouch RK, Caprioli RM, Schey KL. Bis(monoacylglycero)phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas. Scientific Reports. 7: 17352. PMID 29229934 DOI: 10.1038/S41598-017-17402-1  0.381
2017 Ryan DJ, Nei D, Prentice BM, Rose KL, Caprioli RM, Spraggins JM. Protein Identification in Imaging Mass Spectrometry through Spatially Targeted Liquid Micro-Extractions. Rapid Communications in Mass Spectrometry : Rcm. PMID 29226434 DOI: 10.1002/Rcm.8042  0.387
2017 Verbeeck N, Spraggins JM, Murphy MJ, Wang HD, Deutch AY, Caprioli RM, de Plas RV. Connecting Imaging Mass Spectrometry and Magnetic Resonance Imaging-based Anatomical Atlases for Automated Anatomical Interpretation and Differential Analysis. Biochimica Et Biophysica Acta. PMID 28254588 DOI: 10.1016/J.Bbapap.2017.02.016  0.398
2017 Norris JL, Farrow MA, Gutierrez DB, Palmer LD, Muszynski N, Sherrod SD, Pino JC, Allen JL, Spraggins JM, Lubbock AL, Jordan AT, Burns W, Poland JC, Romer CE, Manier ML, et al. An integrated, high-throughput, multi-omics platform enables data-driven construction of cellular responses and reveals global drug mechanisms of action. Journal of Proteome Research. PMID 28088864 DOI: 10.1021/Acs.Jproteome.6B01004  0.309
2017 Kleinridders A, Ferris H, Reyzer M, Rath M, Soto M, Spraggins J, Caprioli R, Kahn C. Regional nrain glucose metabolism determined by imaging mass spectrometry Diabetologie Und Stoffwechsel. 12: S1-S84. DOI: 10.1055/S-0037-1601726  0.368
2016 Nye-Wood MG, Spraggins JM, Caprioli RM, Schey KL, Donaldson PJ, Grey AC. Spatial distributions of glutathione and its endogenous conjugates in normal bovine lens and a model of lens aging. Experimental Eye Research. PMID 27838309 DOI: 10.1016/J.Exer.2016.11.008  0.396
2016 Zubair F, Laibinis PE, Swisher WG, Yang J, Spraggins JM, Norris JL, Caprioli RM. Trypsin and MALDI matrix pre-coated targets simplify sample preparation for mapping proteomic distributions within biological tissues by imaging mass spectrometry. Journal of Mass Spectrometry : Jms. PMID 27676701 DOI: 10.1002/Jms.3888  0.439
2016 Spraggins JM, Rizzo DG, Moore JL, Noto MJ, Skaar EP, Caprioli RM. Next-generation technologies for spatial proteomics: Integrating ultra-high speed MALDI-TOF and high mass resolution MALDI FTICR imaging mass spectrometry for protein analysis. Proteomics. PMID 27060368 DOI: 10.1002/Pmic.201600003  0.487
2015 de Macedo CS, Anderson DM, Pascarelli BM, Spraggins JM, Sarno EN, Schey KL, Pessolani MC. MALDI imaging reveals lipid changes in the skin of leprosy patients before and after multidrug therapy (MDT). Journal of Mass Spectrometry : Jms. 50: 1374-85. PMID 26634971 DOI: 10.1002/Jms.3708  0.335
2015 Wenke JL, Rose KL, Spraggins JM, Schey KL. MALDI Imaging Mass Spectrometry Spatially Maps Age-Related Deamidation and Truncation of Human Lens Aquaporin-0. Investigative Ophthalmology & Visual Science. 56: 7398-7405. PMID 26574799 DOI: 10.1167/Iovs.15-18117  0.426
2015 Gessel M, Spraggins JM, Voziyan P, Hudson BG, Caprioli RM. Decellularization of intact tissue enables MALDI imaging mass spectrometry analysis of the extracellular matrix. Journal of Mass Spectrometry : Jms. 50: 1288-93. PMID 26505774 DOI: 10.1002/Jms.3696  0.449
2015 Wijetunge CD, Saeed I, Boughton BA, Spraggins JM, Caprioli RM, Bacic A, Roessner U, Halgamuge SK. EXIMS: an improved data analysis pipeline based on a new peak picking method for EXploring Imaging Mass Spectrometry data. Bioinformatics (Oxford, England). PMID 26063840 DOI: 10.1093/Bioinformatics/Btv356  0.392
2015 Spraggins JM, Rizzo DG, Moore JL, Rose KL, Hammer ND, Skaar EP, Caprioli RM. MALDI FTICR IMS of Intact Proteins: Using Mass Accuracy to Link Protein Images with Proteomics Data. Journal of the American Society For Mass Spectrometry. 26: 974-85. PMID 25904064 DOI: 10.1007/S13361-015-1147-5  0.439
2015 Anderson DM, Spraggins JM, Rose KL, Schey KL. High spatial resolution imaging mass spectrometry of human optic nerve lipids and proteins. Journal of the American Society For Mass Spectrometry. 26: 940-7. PMID 25893273 DOI: 10.1007/S13361-015-1143-9  0.303
2015 Marien E, Meister M, Muley T, Fieuws S, Bordel S, Derua R, Spraggins J, Van de Plas R, Dehairs J, Wouters J, Bagadi M, Dienemann H, Thomas M, Schnabel PA, Caprioli RM, et al. Non-small cell lung cancer is characterized by dramatic changes in phospholipid profiles. International Journal of Cancer. Journal International Du Cancer. 137: 1539-48. PMID 25784292 DOI: 10.1002/Ijc.29517  0.355
2015 Van de Plas R, Yang J, Spraggins J, Caprioli RM. Image fusion of mass spectrometry and microscopy: a multimodality paradigm for molecular tissue mapping. Nature Methods. 12: 366-72. PMID 25707028 DOI: 10.1038/Nmeth.3296  0.459
2014 Manier ML, Spraggins JM, Reyzer ML, Norris JL, Caprioli RM. A derivatization and validation strategy for determining the spatial localization of endogenous amine metabolites in tissues using MALDI imaging mass spectrometry. Journal of Mass Spectrometry : Jms. 49: 665-73. PMID 25044893 DOI: 10.1002/Jms.3411  0.44
2014 Grove KJ, Voziyan PA, Spraggins JM, Wang S, Paueksakon P, Harris RC, Hudson BG, Caprioli RM. Diabetic nephropathy induces alterations in the glomerular and tubule lipid profiles. Journal of Lipid Research. 55: 1375-1385. PMID 24864273 DOI: 10.1194/Jlr.M049189  0.308
2014 Anderson DM, Ablonczy Z, Koutalos Y, Spraggins J, Crouch RK, Caprioli RM, Schey KL. High resolution MALDI imaging mass spectrometry of retinal tissue lipids. Journal of the American Society For Mass Spectrometry. 25: 1394-403. PMID 24819461 DOI: 10.1007/S13361-014-0883-2  0.393
2014 Ablonczy Z, Smith N, Anderson DM, Grey AC, Spraggins J, Koutalos Y, Schey KL, Crouch RK. The utilization of fluorescence to identify the components of lipofuscin by imaging mass spectrometry. Proteomics. 14: 936-44. PMID 24453194 DOI: 10.1002/Pmic.201300406  0.406
2013 Anderson DM, Mills D, Spraggins J, Lambert WS, Calkins DJ, Schey KL. High-resolution matrix-assisted laser desorption ionization-imaging mass spectrometry of lipids in rodent optic nerve tissue. Molecular Vision. 19: 581-92. PMID 23559852  0.302
2012 Thiery G, Mernaugh RL, Yan H, Spraggins JM, Yang J, Parl FF, Caprioli RM. Targeted multiplex imaging mass spectrometry with single chain fragment variable (scfv) recombinant antibodies. Journal of the American Society For Mass Spectrometry. 23: 1689-96. PMID 22869296 DOI: 10.1007/S13361-012-0423-X  0.4
2012 Angel PM, Spraggins JM, Baldwin HS, Caprioli R. Enhanced sensitivity for high spatial resolution lipid analysis by negative ion mode matrix assisted laser desorption ionization imaging mass spectrometry. Analytical Chemistry. 84: 1557-64. PMID 22243218 DOI: 10.1021/Ac202383M  0.462
2011 Spraggins JM, Caprioli RM. High-speed MALDI-TOF imaging mass spectrometry: rapid ion image acquisition and considerations for next generation instrumentation. Journal of the American Society For Mass Spectrometry. 22: 1022-31. PMID 21953043 DOI: 10.1007/S13361-011-0121-0  0.447
2011 Berry KA, Hankin JA, Barkley RM, Spraggins JM, Caprioli RM, Murphy RC. MALDI imaging of lipid biochemistry in tissues by mass spectrometry. Chemical Reviews. 111: 6491-512. PMID 21942646 DOI: 10.1021/Cr200280P  0.422
2009 Spraggins JM, Lloyd JA, Johnston MV, Laskin J, Ridge DP. Fragmentation mechanisms of oxidized peptides elucidated by SID, RRKM modeling, and molecular dynamics. Journal of the American Society For Mass Spectrometry. 20: 1579-92. PMID 19560936 DOI: 10.1016/J.Jasms.2009.04.012  0.519
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