Jonathan Kipnis - Publications

Affiliations: 
University of Virginia, Charlottesville, VA 
Area:
neuroimmunology, cognition, CNS injury, neuroprotection, neurogenesis, synaptogenesis, mental diseases
Website:
http://www.healthsystem.virginia.edu/internet/neurosci/faculty/kipnis/home.cfm

153 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Xu W, Rustenhoven J, Nelson CA, Dykstra T, Ferreiro A, Papadopoulos Z, Burnham CD, Dantas G, Fremont DH, Kipnis J. A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan. Neuron. PMID 37582366 DOI: 10.1016/j.neuron.2023.07.010  0.799
2023 Drieu A, Du S, Kipnis M, Bosch ME, Herz J, Lee C, Jiang H, Manis M, Ulrich JD, Kipnis J, Holtzman DM, Gratuze M. Parenchymal border macrophages regulate tau pathology and tau-mediated neurodegeneration. Life Science Alliance. 6. PMID 37562846 DOI: 10.26508/lsa.202302087  0.699
2023 Mamuladze T, Kipnis J. Type 2 immunity in the brain and brain borders. Cellular & Molecular Immunology. PMID 37429945 DOI: 10.1038/s41423-023-01043-8  0.326
2023 Salvador AFM, Dykstra T, Rustenhoven J, Gao W, Blackburn SM, Bhasiin K, Dong MQ, Guimarães RM, Gonuguntla S, Smirnov I, Kipnis J, Herz J. Age-dependent immune and lymphatic responses after spinal cord injury. Neuron. PMID 37148871 DOI: 10.1016/j.neuron.2023.04.011  0.786
2023 Brase L, You SF, D'Oliveira Albanus R, Del-Aguila JL, Dai Y, Novotny BC, Soriano-Tarraga C, Dykstra T, Fernandez MV, Budde JP, Bergmann K, Morris JC, Bateman RJ, Perrin RJ, McDade E, ... ... Kipnis J, et al. Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers. Nature Communications. 14: 2314. PMID 37085492 DOI: 10.1038/s41467-023-37437-5  0.774
2023 Rustenhoven J, Pavlou G, Storck SE, Dykstra T, Du S, Wan Z, Quintero D, Scallan JP, Smirnov I, Kamm RD, Kipnis J. Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage. The Journal of Experimental Medicine. 220. PMID 37027179 DOI: 10.1084/jem.20221929  0.809
2023 Chen X, Firulyova M, Manis M, Herz J, Smirnov I, Aladyeva E, Wang C, Bao X, Finn MB, Hu H, Shchukina I, Kim MW, Yuede CM, Kipnis J, Artyomov MN, et al. Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy. Nature. PMID 36890231 DOI: 10.1038/s41586-023-05788-0  0.756
2023 Kim MW, Kipnis J. Picking a (neuroimmune) fight against fragile regulation of addiction. Cell. PMID 36693375 DOI: 10.1016/j.cell.2023.01.003  0.329
2023 Seo DO, O'Donnell D, Jain N, Ulrich JD, Herz J, Li Y, Lemieux M, Cheng J, Hu H, Serrano JR, Bao X, Franke E, Karlsson M, Meier M, Deng S, ... ... Kipnis J, et al. ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy. Science (New York, N.Y.). 379: eadd1236. PMID 36634180 DOI: 10.1126/science.add1236  0.697
2022 Goldman DH, Dykstra T, Smirnov I, Blackburn SM, Da Mesquita S, Kipnis J, Herz J. Age-associated suppression of exploratory activity during sickness is linked to meningeal lymphatic dysfunction and microglia activation. Nature Aging. 2: 704-713. PMID 37065770 DOI: 10.1038/s43587-022-00268-y  0.803
2022 Rustenhoven J, Kipnis J. Brain borders at the central stage of neuroimmunology. Nature. 612: 417-429. PMID 36517712 DOI: 10.1038/s41586-022-05474-7  0.332
2022 Drieu A, Du S, Storck SE, Rustenhoven J, Papadopoulos Z, Dykstra T, Zhong F, Kim K, Blackburn S, Mamuladze T, Harari O, Karch CM, Bateman RJ, Perrin R, Farlow M, ... ... Kipnis J, et al. Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid. Nature. PMID 36352225 DOI: 10.1038/s41586-022-05397-3  0.792
2022 Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, ... ... Kipnis J, et al. Microglia states and nomenclature: A field at its crossroads. Neuron. 110: 3458-3483. PMID 36327895 DOI: 10.1016/j.neuron.2022.10.020  0.41
2022 Silvin A, Uderhardt S, Piot C, Da Mesquita S, Yang K, Geirsdottir L, Mulder K, Eyal D, Liu Z, Bridlance C, Thion MS, Zhang XM, Kong WT, Deloger M, Fontes V, ... ... Kipnis J, et al. Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration. Immunity. 55: 1448-1465.e6. PMID 35931085 DOI: 10.1016/j.immuni.2022.07.004  0.767
2022 Salvador AFM, Kipnis J. Immune response after central nervous system injury. Seminars in Immunology. 101629. PMID 35753867 DOI: 10.1016/j.smim.2022.101629  0.338
2022 Mazzitelli JA, Smyth LCD, Cross KA, Dykstra T, Sun J, Du S, Mamuladze T, Smirnov I, Rustenhoven J, Kipnis J. Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels. Nature Neuroscience. PMID 35301477 DOI: 10.1038/s41593-022-01029-1  0.781
2022 Derecki NC, Kipnis J. Retraction Note: From neurons to microglia, with complements. Nature Neuroscience. PMID 35027763 DOI: 10.1038/s41593-021-00892-8  0.709
2021 Herz J, Fu Z, Kim K, Dykstra T, Wall M, Li H, Salvador AF, Zou B, Yan N, Blackburn SM, Andrews PH, Goldman DH, Papadopoulos Z, Smirnov I, Xie XS, ... Kipnis J, et al. GABAergic neuronal IL-4R mediates T cell effect on memory. Neuron. 109: 3609-3618.e9. PMID 34793707 DOI: 10.1016/j.neuron.2021.10.022  0.805
2021 Cugurra A, Mamuladze T, Rustenhoven J, Dykstra T, Beroshvili G, Greenberg ZJ, Baker W, Papadopoulos Z, Drieu A, Blackburn S, Kanamori M, Brioschi S, Herz J, Schuettpelz LG, Colonna M, ... ... Kipnis J, et al. Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma. Science (New York, N.Y.). PMID 34083447 DOI: 10.1126/science.abf7844  0.817
2021 Da Mesquita S, Herz J, Wall M, Dykstra T, de Lima KA, Norris GT, Dabhi N, Kennedy T, Baker W, Kipnis J. Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology. Science Advances. 7. PMID 34020948 DOI: 10.1126/sciadv.abe4601  0.817
2021 Da Mesquita S, Papadopoulos Z, Dykstra T, Brase L, Farias FG, Wall M, Jiang H, Kodira CD, de Lima KA, Herz J, Louveau A, Goldman DH, Salvador AF, Onengut-Gumuscu S, Farber E, ... ... Kipnis J, et al. Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy. Nature. PMID 33911285 DOI: 10.1038/s41586-021-03489-0  0.774
2021 Rustenhoven J, Drieu A, Mamuladze T, de Lima KA, Dykstra T, Wall M, Papadopoulos Z, Kanamori M, Salvador AF, Baker W, Lemieux M, Da Mesquita S, Cugurra A, Fitzpatrick J, Sviben S, ... ... Kipnis J, et al. Functional characterization of the dural sinuses as a neuroimmune interface. Cell. PMID 33508229 DOI: 10.1016/j.cell.2020.12.040  0.823
2020 Alves de Lima K, Rustenhoven J, Da Mesquita S, Wall M, Salvador AF, Smirnov I, Martelossi Cebinelli G, Mamuladze T, Baker W, Papadopoulos Z, Lopes MB, Cao WS, Xie XS, Herz J, Kipnis J. Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons. Nature Immunology. PMID 32929273 DOI: 10.1038/S41590-020-0776-4  0.786
2020 Bolte AC, Dutta AB, Hurt ME, Smirnov I, Kovacs MA, McKee CA, Ennerfelt HE, Shapiro D, Nguyen BH, Frost EL, Lammert CR, Kipnis J, Lukens JR. Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis. Nature Communications. 11: 4524. PMID 32913280 DOI: 10.1038/S41467-020-18113-4  0.357
2020 Oliver G, Kipnis J, Randolph GJ, Harvey NL. The Lymphatic Vasculature in the 21 Century: Novel Functional Roles in Homeostasis and Disease. Cell. 182: 270-296. PMID 32707093 DOI: 10.1016/j.cell.2020.06.039  0.355
2020 Alves de Lima K, Rustenhoven J, Kipnis J. Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease. Annual Review of Immunology. 38: 597-620. PMID 32340575 DOI: 10.1146/annurev-immunol-102319-103410  0.463
2020 Papadopoulos Z, Herz J, Kipnis J. Meningeal Lymphatics: From Anatomy to Central Nervous System Immune Surveillance. Journal of Immunology (Baltimore, Md. : 1950). 204: 286-293. PMID 31907271 DOI: 10.4049/Jimmunol.1900838  0.767
2019 Rustenhoven J, Kipnis J. Smelling Danger: Olfactory Stem Cells Control Immune Defense during Chronic Inflammation. Cell Stem Cell. 25: 449-451. PMID 31585089 DOI: 10.1016/j.stem.2019.09.006  0.343
2019 Rustenhoven J, Herz J, Kipnis J. Old T Cells Interfer(on) with Neurogenesis. Trends in Immunology. PMID 31422900 DOI: 10.1016/J.It.2019.07.007  0.751
2019 Sandrone S, Moreno-Zambrano D, Kipnis J, van Gijn J. A (delayed) history of the brain lymphatic system. Nature Medicine. 25: 538-540. PMID 30948855 DOI: 10.1038/s41591-019-0417-3  0.317
2019 Norris GT, Kipnis J. Immune cells and CNS physiology: Microglia and beyond. The Journal of Experimental Medicine. 216: 60-70. PMID 30504438 DOI: 10.1084/jem.20180199  0.442
2018 Da Mesquita S, Louveau A, Vaccari A, Smirnov I, Cornelison RC, Kingsmore KM, Contarino C, Onengut-Gumuscu S, Farber E, Raper D, Viar KE, Powell RD, Baker W, Dabhi N, Bai R, ... ... Kipnis J, et al. Publisher Correction: Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease. Nature. PMID 30397347 DOI: 10.1038/S41586-018-0689-7  0.765
2018 Da Mesquita S, Fu Z, Kipnis J. The Meningeal Lymphatic System: A New Player in Neurophysiology. Neuron. 100: 375-388. PMID 30359603 DOI: 10.1016/j.neuron.2018.09.022  0.785
2018 Herz J, Louveau A, Da Mesquita S, Kipnis J. Morphological and Functional Analysis of CNS-Associated Lymphatics. Methods in Molecular Biology (Clifton, N.J.). 1846: 141-151. PMID 30242757 DOI: 10.1007/978-1-4939-8712-2_9  0.789
2018 Louveau A, Herz J, Alme MN, Salvador AF, Dong MQ, Viar KE, Herod SG, Knopp J, Setliff JC, Lupi AL, Da Mesquita S, Frost EL, Gaultier A, Harris TH, Cao R, ... ... Kipnis J, et al. CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature. Nature Neuroscience. PMID 30224810 DOI: 10.1038/S41593-018-0227-9  0.831
2018 Da Mesquita S, Louveau A, Vaccari A, Smirnov I, Cornelison RC, Kingsmore KM, Contarino C, Onengut-Gumuscu S, Farber E, Raper D, Viar KE, Powell RD, Baker W, Dabhi N, Bai R, ... ... Kipnis J, et al. Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease. Nature. PMID 30046111 DOI: 10.1038/S41586-018-0368-8  0.808
2018 Louveau A, Filiano AJ, Kipnis J. Meningeal whole mount preparation and characterization of neural cells by flow cytometry. Current Protocols in Immunology. 121. PMID 30008983 DOI: 10.1002/Cpim.50  0.818
2018 Norris GT, Smirnov I, Filiano AJ, Shadowen HM, Cody KR, Thompson JA, Harris TH, Gaultier A, Overall CC, Kipnis J. Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury. The Journal of Experimental Medicine. PMID 29941548 DOI: 10.1084/Jem.20172244  0.699
2018 Cronk JC, Filiano AJ, Louveau A, Marin I, Marsh R, Ji E, Goldman DH, Smirnov I, Geraci N, Acton S, Overall CC, Kipnis J. Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia. The Journal of Experimental Medicine. PMID 29643186 DOI: 10.1084/Jem.20180247  0.813
2018 Mrdjen D, Pavlovic A, Hartmann FJ, Schreiner B, Utz SG, Leung BP, Lelios I, Heppner FL, Kipnis J, Merkler D, Greter M, Becher B. High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease. Immunity. PMID 29426702 DOI: 10.1016/J.Immuni.2018.01.011  0.46
2018 Louveau A, Kipnis J. Sex, Gut, and Microglia. Developmental Cell. 44: 137-138. PMID 29401417 DOI: 10.1016/J.Devcel.2018.01.003  0.723
2018 Kipnis J. Immune system: The "seventh sense". The Journal of Experimental Medicine. PMID 29339443 DOI: 10.1084/jem.20172295  0.365
2017 Kipnis J, Filiano AJ. Neuroimmunology in 2017: The central nervous system: privileged by immune connections. Nature Reviews. Immunology. PMID 29279610 DOI: 10.1038/Nri.2017.152  0.713
2017 Absinta M, Ha SK, Nair G, Sati P, Luciano NJ, Palisoc M, Louveau A, Zaghloul KA, Pittaluga S, Kipnis J, Reich DS. Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI. Elife. 6. PMID 28971799 DOI: 10.7554/Elife.29738  0.739
2017 Louveau A, Plog BA, Antila S, Alitalo K, Nedergaard M, Kipnis J. Understanding the functions and relationships of the glymphatic system and meningeal lymphatics. The Journal of Clinical Investigation. 127: 3210-3219. PMID 28862640 DOI: 10.1172/Jci90603  0.748
2017 Jung E, Gardner D, Choi D, Park E, Jin Seong Y, Yang S, Castorena-Gonzalez J, Louveau A, Zhou Z, Lee GK, Perrault DP, Lee S, Johnson M, Daghlian G, Lee M, ... ... Kipnis J, et al. Development and Characterization of A Novel Prox1-EGFP Lymphatic and Schlemm's Canal Reporter Rat. Scientific Reports. 7: 5577. PMID 28717161 DOI: 10.1038/S41598-017-06031-3  0.7
2017 Herz J, Filiano AJ, Smith A, Yogev N, Kipnis J. Myeloid Cells in the Central Nervous System. Immunity. 46: 943-956. PMID 28636961 DOI: 10.1016/J.Immuni.2017.06.007  0.821
2017 Da Mesquita S, Kipnis J. DAMed in (Trem) 2 Steps. Cell. 169: 1172-1174. PMID 28622503 DOI: 10.1016/j.cell.2017.05.039  0.744
2017 Filiano AJ, Gadani SP, Kipnis J. How and why do T cells and their derived cytokines affect the injured and healthy brain? Nature Reviews. Neuroscience. PMID 28446786 DOI: 10.1038/Nrn.2017.39  0.812
2017 Cronk JC, Herz J, Kim TS, Louveau A, Moser EK, Sharma AK, Smirnov I, Tung KS, Braciale TJ, Kipnis J. Influenza A induces dysfunctional immunity and death in MeCP2-overexpressing mice. Jci Insight. 2: e88257. PMID 28138553 DOI: 10.1172/Jci.Insight.88257  0.803
2017 Absinta M, Ha S, Nair G, Sati P, Luciano NJ, Palisoc M, Louveau A, Zaghloul KA, Pittaluga S, Kipnis J, Reich DS. Author response: Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI Elife. DOI: 10.7554/Elife.29738.018  0.717
2016 Gadani SP, Smirnov I, Smith AT, Overall CC, Kipnis J. Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury. The Journal of Experimental Medicine. PMID 27994070 DOI: 10.1084/Jem.20161982  0.764
2016 Louveau A, Da Mesquita S, Kipnis J. Lymphatics in Neurological Disorders: A Neuro-Lympho-Vascular Component of Multiple Sclerosis and Alzheimer's Disease? Neuron. 91: 957-73. PMID 27608759 DOI: 10.1016/J.Neuron.2016.08.027  0.811
2016 Kipnis J. Multifaceted interactions between adaptive immunity and the central nervous system. Science (New York, N.Y.). 353: 766-71. PMID 27540163 DOI: 10.1126/science.aag2638  0.457
2016 Raper D, Louveau A, Kipnis J. How Do Meningeal Lymphatic Vessels Drain the CNS? Trends in Neurosciences. PMID 27460561 DOI: 10.1016/J.Tins.2016.07.001  0.741
2016 Filiano AJ, Xu Y, Tustison NJ, Marsh RL, Baker W, Smirnov I, Overall CC, Gadani SP, Turner SD, Weng Z, Peerzade SN, Chen H, Lee KS, Scott MM, Beenhakker MP, ... ... Kipnis J, et al. Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour. Nature. PMID 27409813 DOI: 10.1038/Nature18626  0.801
2016 Marin IA, Kipnis J. Central Nervous System: (Immunological) Ivory Tower or Not? Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27402496 DOI: 10.1038/npp.2016.122  0.461
2016 Herz J, Kipnis J. Bugs and Brain: How Infection Makes You Feel Blue. Immunity. 44: 718-20. PMID 27096312 DOI: 10.1016/J.Immuni.2016.03.010  0.738
2016 Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, Derecki NC, Castle D, Mandell JW, Lee KS, Harris TH, Kipnis J. Corrigendum: Structural and functional features of central nervous system lymphatic vessels. Nature. PMID 26909581 DOI: 10.1038/Nature16999  0.779
2016 Gadani SP, Kipnis J. Shedding light on IL-33 in the eye. The Journal of Experimental Medicine. 213: 141. PMID 26858363 DOI: 10.1084/jem.2132insight2  0.711
2016 Gadani SP, Kipnis J. Natural killers in the brain's nursery. Nature Neuroscience. 19: 176-7. PMID 26814583 DOI: 10.1038/nn.4227  0.764
2016 Ellwardt E, Walsh JT, Kipnis J, Zipp F. Understanding the Role of T Cells in CNS Homeostasis. Trends in Immunology. PMID 26775912 DOI: 10.1016/j.it.2015.12.008  0.432
2015 Louveau A, Harris TH, Kipnis J. Revisiting the Mechanisms of CNS Immune Privilege. Trends in Immunology. 36: 569-77. PMID 26431936 DOI: 10.1016/J.It.2015.08.006  0.753
2015 Filiano AJ, Kipnis J. Breaking bad blood: β2-microglobulin as a pro-aging factor in blood. Nature Medicine. 21: 844-5. PMID 26248266 DOI: 10.1038/Nm.3926  0.662
2015 Gadani SP, Walsh JT, Lukens JR, Kipnis J. Dealing with Danger in the CNS: The Response of the Immune System to Injury. Neuron. 87: 47-62. PMID 26139369 DOI: 10.1016/J.Neuron.2015.05.019  0.775
2015 Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, Derecki NC, Castle D, Mandell JW, Lee KS, Harris TH, Kipnis J. Structural and functional features of central nervous system lymphatic vessels. Nature. 523: 337-41. PMID 26030524 DOI: 10.1038/Nature14432  0.825
2015 Cronk JC, Derecki NC, Litvak V, Kipnis J. Unexpected cellular players in Rett syndrome pathology. Neurobiology of Disease. PMID 25982834 DOI: 10.1016/J.Nbd.2015.05.005  0.758
2015 Walsh JT, Hendrix S, Boato F, Smirnov I, Zheng J, Lukens JR, Gadani S, Hechler D, Gölz G, Rosenberger K, Kammertöns T, Vogt J, Vogelaar C, Siffrin V, Radjavi A, ... ... Kipnis J, et al. MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4. The Journal of Clinical Investigation. 125: 2547. PMID 25938785 DOI: 10.1172/JCI82458  0.726
2015 Cronk JC, Derecki NC, Ji E, Xu Y, Lampano AE, Smirnov I, Baker W, Norris GT, Marin I, Coddington N, Wolf Y, Turner SD, Aderem A, Klibanov AL, Harris TH, ... ... Kipnis J, et al. Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli. Immunity. 42: 679-91. PMID 25902482 DOI: 10.1016/J.Immuni.2015.03.013  0.753
2015 Gadani SP, Kipnis J. Brainless immunity no more. Nature Immunology. 16: 440-1. PMID 25898188 DOI: 10.1038/ni.3145  0.739
2015 Gadani SP, Walsh JT, Smirnov I, Zheng J, Kipnis J. The glia-derived alarmin IL-33 orchestrates the immune response and promotes recovery following CNS injury. Neuron. 85: 703-9. PMID 25661185 DOI: 10.1016/j.neuron.2015.01.013  0.761
2015 Walsh JT, Hendrix S, Boato F, Smirnov I, Zheng J, Lukens JR, Gadani S, Hechler D, Gölz G, Rosenberger K, Kammertöns T, Vogt J, Vogelaar C, Siffrin V, Radjavi A, ... ... Kipnis J, et al. MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4. The Journal of Clinical Investigation. 125: 699-714. PMID 25607842 DOI: 10.1172/Jci76210  0.768
2015 Filiano AJ, Gadani SP, Kipnis J. Interactions of innate and adaptive immunity in brain development and function. Brain Research. 1617: 18-27. PMID 25110235 DOI: 10.1016/J.Brainres.2014.07.050  0.825
2014 Walsh JT, Zheng J, Smirnov I, Lorenz U, Tung K, Kipnis J. Regulatory T cells in central nervous system injury: a double-edged sword. Journal of Immunology (Baltimore, Md. : 1950). 193: 5013-22. PMID 25320276 DOI: 10.4049/Jimmunol.1302401  0.411
2014 Derecki NC, Katzmarski N, Kipnis J, Meyer-Luehmann M. Microglia as a critical player in both developmental and late-life CNS pathologies. Acta Neuropathologica. 128: 333-45. PMID 25056803 DOI: 10.1007/S00401-014-1321-Z  0.784
2014 Walsh JT, Watson N, Kipnis J. T cells in the central nervous system: messengers of destruction or purveyors of protection? Immunology. 141: 340-4. PMID 24708415 DOI: 10.1111/imm.12187  0.468
2014 Radjavi A, Smirnov I, Kipnis J. Brain antigen-reactive CD4+ T cells are sufficient to support learning behavior in mice with limited T cell repertoire. Brain, Behavior, and Immunity. 35: 58-63. PMID 24012647 DOI: 10.1016/j.bbi.2013.08.013  0.395
2014 Radjavi A, Smirnov I, Derecki N, Kipnis J. Dynamics of the meningeal CD4(+) T-cell repertoire are defined by the cervical lymph nodes and facilitate cognitive task performance in mice. Molecular Psychiatry. 19: 531-3. PMID 23752249 DOI: 10.1038/Mp.2013.79  0.778
2014 Derecki N, Kipnis J. Mouse meninges isolation for FACS Protocol Exchange. DOI: 10.1038/Protex.2014.030  0.707
2014 Norris G, Derecki N, Kipnis J. Microglial Sholl Analysis Protocol Exchange. DOI: 10.1038/Protex.2014.029  0.706
2014 Louveau A, Gadani S, Harris T, Kipnis J. Chemokine-induced trafficking of T cells into the meninges through the brain "gates" Journal of Neuroimmunology. 275: 202. DOI: 10.1016/J.Jneuroim.2014.08.543  0.792
2014 Filiano A, Gadani S, Huberts A, Marsh R, Kipnis J. 87. T cell malfunction and a pro-inflammatory skew in autism spectrum disorders Brain, Behavior, and Immunity. 40: e25-e26. DOI: 10.1016/J.Bbi.2014.06.107  0.822
2013 Cronk JC, Kipnis J. Microglia - the brain's busy bees. F1000prime Reports. 5: 53. PMID 24381729 DOI: 10.12703/P5-53  0.431
2013 Derecki NC, Kipnis J. From neurons to microglia, with complements. Nature Neuroscience. 16: 1712-3. PMID 24270269 DOI: 10.1038/Nn.3579  0.728
2013 Schwartz M, Kipnis J, Rivest S, Prat A. How do immune cells support and shape the brain in health, disease, and aging? The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 17587-96. PMID 24198349 DOI: 10.1523/Jneurosci.3241-13.2013  0.634
2013 Marin I, Kipnis J. Learning and memory ... and the immune system. Learning & Memory (Cold Spring Harbor, N.Y.). 20: 601-6. PMID 24051097 DOI: 10.1101/lm.028357.112  0.433
2013 Derecki NC, Cronk JC, Kipnis J. The role of microglia in brain maintenance: implications for Rett syndrome. Trends in Immunology. 34: 144-50. PMID 23122051 DOI: 10.1016/J.It.2012.10.002  0.789
2012 Gadani SP, Cronk JC, Norris GT, Kipnis J. IL-4 in the brain: a cytokine to remember. Journal of Immunology (Baltimore, Md. : 1950). 189: 4213-9. PMID 23087426 DOI: 10.4049/jimmunol.1202246  0.747
2012 Kipnis J, Gadani S, Derecki NC. Pro-cognitive properties of T cells. Nature Reviews. Immunology. 12: 663-9. PMID 22903149 DOI: 10.1038/Nri3280  0.819
2012 Derecki NC, Cronk JC, Lu Z, Xu E, Abbott SB, Guyenet PG, Kipnis J. Wild-type microglia arrest pathology in a mouse model of Rett syndrome. Nature. 484: 105-9. PMID 22425995 DOI: 10.1038/Nature10907  0.758
2012 Cronk J, Derecki N, Kipnis J. Measurement of neuron soma size by fluorescent Nissl stain Protocol Exchange. DOI: 10.1038/Protex.2012.022  0.706
2012 Derecki N, Cronk J, Kipnis J. Assay of phagocytic function in primary murine microglia Protocol Exchange. DOI: 10.1038/Protex.2012.017  0.727
2012 Derecki N, Cronk J, Kipnis J. FACS of acutely isolated mouse microglia Protocol Exchange. DOI: 10.1038/Protex.2012.016  0.711
2011 Lu Z, Elliott MR, Chen Y, Walsh JT, Klibanov AL, Ravichandran KS, Kipnis J. Phagocytic activity of neuronal progenitors regulates adult neurogenesis. Nature Cell Biology. 13: 1076-83. PMID 21804544 DOI: 10.1038/ncb2299  0.346
2011 Walsh JT, Kipnis J. Regulatory T cells in CNS injury: the simple, the complex and the confused. Trends in Molecular Medicine. 17: 541-7. PMID 21741881 DOI: 10.1016/j.molmed.2011.05.012  0.432
2011 Schwartz M, Kipnis J. A conceptual revolution in the relationships between the brain and immunity. Brain, Behavior, and Immunity. 25: 817-9. PMID 21187141 DOI: 10.1016/J.Bbi.2010.12.015  0.605
2011 Derecki NC, Quinnies KM, Kipnis J. Alternatively activated myeloid (M2) cells enhance cognitive function in immune compromised mice. Brain, Behavior, and Immunity. 25: 379-85. PMID 21093578 DOI: 10.1016/J.Bbi.2010.11.009  0.791
2010 Derecki NC, Cardani AN, Yang CH, Quinnies KM, Crihfield A, Lynch KR, Kipnis J. Regulation of learning and memory by meningeal immunity: a key role for IL-4. The Journal of Experimental Medicine. 207: 1067-80. PMID 20439540 DOI: 10.1084/Jem.20091419  0.776
2010 Derecki NC, Privman E, Kipnis J. Rett syndrome and other autism spectrum disorders--brain diseases of immune malfunction? Molecular Psychiatry. 15: 355-63. PMID 20177406 DOI: 10.1038/Mp.2010.21  0.786
2010 Lu Z, Kipnis J. Thrombospondin 1--a key astrocyte-derived neurogenic factor. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 1925-34. PMID 20124433 DOI: 10.1096/fj.09-150573  0.338
2010 Kipnis J. Meningeal immunity – A new player in regulation of cognitive function Brain Behavior and Immunity. 24. DOI: 10.1016/J.Bbi.2010.07.211  0.346
2009 Yan Z, Garg SK, Kipnis J, Banerjee R. Extracellular redox modulation by regulatory T cells. Nature Chemical Biology. 5: 721-3. PMID 19718041 DOI: 10.1038/Nchembio.212  0.367
2009 Garg SK, Kipnis J, Banerjee R. IFN-gamma and IL-4 differentially shape metabolic responses and neuroprotective phenotype of astrocytes. Journal of Neurochemistry. 108: 1155-66. PMID 19141080 DOI: 10.1111/J.1471-4159.2009.05872.X  0.315
2009 Kipnis J, Derecki N. 68. Role of T cells in cognition and neural plasticity Brain, Behavior, and Immunity. 23: S43-S44. DOI: 10.1016/J.Bbi.2009.06.073  0.748
2008 Kipnis J, Derecki NC, Yang C, Scrable H. Immunity and cognition: what do age-related dementia, HIV-dementia and 'chemo-brain' have in common? Trends in Immunology. 29: 455-63. PMID 18789764 DOI: 10.1016/J.It.2008.07.007  0.791
2008 Yamamoto M, Kiyota T, Walsh SM, Liu J, Kipnis J, Ikezu T. Cytokine-mediated inhibition of fibrillar amyloid-beta peptide degradation by human mononuclear phagocytes. Journal of Immunology (Baltimore, Md. : 1950). 181: 3877-86. PMID 18768842 DOI: 10.4049/Jimmunol.181.6.3877  0.308
2008 Hanisch UK, Johnson TV, Kipnis J. Toll-like receptors: roles in neuroprotection? Trends in Neurosciences. 31: 176-82. PMID 18329736 DOI: 10.1016/j.tins.2008.01.005  0.398
2008 Garg SK, Banerjee R, Kipnis J. Neuroprotective immunity: T cell-derived glutamate endows astrocytes with a neuroprotective phenotype. Journal of Immunology (Baltimore, Md. : 1950). 180: 3866-73. PMID 18322194 DOI: 10.4049/Jimmunol.180.6.3866  0.386
2008 Brynskikh A, Warren T, Zhu J, Kipnis J. Adaptive immunity affects learning behavior in mice. Brain, Behavior, and Immunity. 22: 861-9. PMID 18249087 DOI: 10.1016/J.Bbi.2007.12.008  0.39
2008 Gorantla S, Liu J, Wang T, Holguin A, Sneller HM, Dou H, Kipnis J, Poluektova L, Gendelman HE. Modulation of innate immunity by copolymer-1 leads to neuroprotection in murine HIV-1 encephalitis. Glia. 56: 223-32. PMID 18046731 DOI: 10.1002/Glia.20607  0.366
2008 Zhang Y, Zhou Y, Schweizer U, Savaskan NE, Hua D, Kipnis J, Hatfield DL, Gladyshev VN. Comparative analysis of selenocysteine machinery and selenoproteome gene expression in mouse brain identifies neurons as key functional sites of selenium in mammals. The Journal of Biological Chemistry. 283: 2427-38. PMID 18032379 DOI: 10.1074/Jbc.M707951200  0.331
2008 Kipnis J, Schwartz M. Protective and regenerative autoimmunity in CNS injury Neuroimmune Pharmacology. 661-677. DOI: 10.1007/978-0-387-72573-4_45  0.419
2007 Schwartz M, Kipnis J. Model of acute injury to study neuroprotection. Methods in Molecular Biology (Clifton, N.J.). 399: 41-53. PMID 18309924 DOI: 10.1007/978-1-59745-504-6_4  0.513
2007 Liu J, Johnson TV, Lin J, Ramirez SH, Bronich TK, Caplan S, Persidsky Y, Gendelman HE, Kipnis J. T cell independent mechanism for copolymer-1-induced neuroprotection. European Journal of Immunology. 37: 3143-54. PMID 17948266 DOI: 10.1002/Eji.200737398  0.425
2007 Lewitus GM, Zhu J, Xiong H, Hallworth R, Kipnis J. CD4(+)CD25(-) effector T-cells inhibit hippocampal long-term potentiation in vitro. The European Journal of Neuroscience. 26: 1399-406. PMID 17880384 DOI: 10.1111/J.1460-9568.2007.05788.X  0.36
2007 Johnson TV, Camras CB, Kipnis J. Bacterial DNA confers neuroprotection after optic nerve injury by suppressing CD4+CD25+ regulatory T-cell activity. Investigative Ophthalmology & Visual Science. 48: 3441-9. PMID 17652711 DOI: 10.1167/iovs.06-1351  0.401
2007 Ziv Y, Finkelstein A, Geffen Y, Kipnis J, Smirnov I, Shpilman S, Vertkin I, Kimron M, Lange A, Hecht T, Reyman KG, Marder JB, Schwartz M, Yoles E. A novel immune-based therapy for stroke induces neuroprotection and supports neurogenesis. Stroke; a Journal of Cerebral Circulation. 38: 774-82. PMID 17261737 DOI: 10.1161/01.Str.0000255784.27298.23  0.554
2006 Schwartz M, Butovsky O, Kipnis J. Does inflammation in an autoimmune disease differ from inflammation in neurodegenerative diseases? Possible implications for therapy. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 1: 4-10. PMID 18040786 DOI: 10.1007/S11481-005-9010-2  0.519
2006 Lewitus GM, Kipnis J, Avidan H, Ben-Nun A, Schwartz M. Neuroprotection induced by mucosal tolerance is epitope-dependent: conflicting effects in different strains. Journal of Neuroimmunology. 175: 31-8. PMID 16626813 DOI: 10.1016/J.Jneuroim.2006.02.013  0.794
2006 Cohen H, Ziv Y, Cardon M, Kaplan Z, Matar MA, Gidron Y, Schwartz M, Kipnis J. Maladaptation to mental stress mitigated by the adaptive immune system via depletion of naturally occurring regulatory CD4+CD25+ cells. Journal of Neurobiology. 66: 552-63. PMID 16555237 DOI: 10.1002/Neu.20249  0.59
2006 Kipnis J, Cardon M, Strous RD, Schwartz M. Loss of autoimmune T cells correlates with brain diseases: possible implications for schizophrenia? Trends in Molecular Medicine. 12: 107-12. PMID 16469540 DOI: 10.1016/J.Molmed.2006.01.003  0.615
2006 Ziv Y, Ron N, Butovsky O, Landa G, Sudai E, Greenberg N, Cohen H, Kipnis J, Schwartz M. Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nature Neuroscience. 9: 268-75. PMID 16415867 DOI: 10.1038/Nn1629  0.594
2006 Liu J, Lin J, Olds P, Bronich T, Persidsky Y, Kipnis J. Sa.4. T-Cell-Independent Neuroprotective Effects of Glatiramer Acetate Clinical Immunology. 119: S106. DOI: 10.1016/J.Clim.2006.04.236  0.34
2006 Lin J, Liu J, Labunskay G, Kipnis J. T cells support brain plasticity and cognition Brain Behavior and Immunity. 20: 43-44. DOI: 10.1016/J.Bbi.2006.04.083  0.366
2005 Kadiu I, Glanzer JG, Kipnis J, Gendelman HE, Thomas MP. Mononuclear phagocytes in the pathogenesis of neurodegenerative diseases. Neurotoxicity Research. 8: 25-50. PMID 16260384 DOI: 10.1007/Bf03033818  0.452
2005 Kipnis J, Schwartz M. Controlled autoimmunity in CNS maintenance and repair: naturally occurring CD4+CD25+ regulatory T-Cells at the crossroads of health and disease. Neuromolecular Medicine. 7: 197-206. PMID 16247180 DOI: 10.1385/Nmm:7:3:197  0.572
2005 Schwartz M, Kipnis J. Therapeutic T cell-based vaccination for neurodegenerative disorders: the role of CD4+CD25+ regulatory T cells. Annals of the New York Academy of Sciences. 1051: 701-8. PMID 16127010 DOI: 10.1196/Annals.1361.114  0.622
2005 Schwartz M, Kipnis J. Protective autoimmunity and neuroprotection in inflammatory and noninflammatory neurodegenerative diseases. Journal of the Neurological Sciences. 233: 163-6. PMID 15949502 DOI: 10.1016/J.Jns.2005.03.014  0.581
2004 Avidan H, Kipnis J, Butovsky O, Caspi RR, Schwartz M. Vaccination with autoantigen protects against aggregated beta-amyloid and glutamate toxicity by controlling microglia: effect of CD4+CD25+ T cells. European Journal of Immunology. 34: 3434-45. PMID 15549735 DOI: 10.1002/Eji.200424883  0.797
2004 Schwartz M, Kipnis J. Self and non-self discrimination is needed for the existence rather than deletion of autoimmunity: the role of regulatory T cells in protective autoimmunity. Cellular and Molecular Life Sciences : Cmls. 61: 2285-9. PMID 15378200 DOI: 10.1007/S00018-004-4233-6  0.505
2004 Kipnis J, Avidan H, Caspi RR, Schwartz M. Dual effect of CD4+CD25+ regulatory T cells in neurodegeneration: a dialogue with microglia. Proceedings of the National Academy of Sciences of the United States of America. 101: 14663-9. PMID 15331781 DOI: 10.1073/Pnas.0404842101  0.813
2004 Schwartz M, Kipnis J. A common vaccine for fighting neurodegenerative disorders: recharging immunity for homeostasis. Trends in Pharmacological Sciences. 25: 407-12. PMID 15276709 DOI: 10.1016/J.Tips.2004.06.010  0.579
2004 Kipnis J, Cardon M, Avidan H, Lewitus GM, Mordechay S, Rolls A, Shani Y, Schwartz M. Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4+CD25+ regulatory T-cell activity: implications for neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 6133-43. PMID 15240805 DOI: 10.1523/Jneurosci.0600-04.2004  0.799
2004 Kipnis J, Cohen H, Cardon M, Ziv Y, Schwartz M. T cell deficiency leads to cognitive dysfunction: implications for therapeutic vaccination for schizophrenia and other psychiatric conditions. Proceedings of the National Academy of Sciences of the United States of America. 101: 8180-5. PMID 15141078 DOI: 10.1073/Pnas.0402268101  0.546
2004 Kipnis J, Avidan H, Markovich Y, Mizrahi T, Hauben E, Prigozhina TB, Slavin S, Schwartz M. Low-dose gamma-irradiation promotes survival of injured neurons in the central nervous system via homeostasis-driven proliferation of T cells. The European Journal of Neuroscience. 19: 1191-8. PMID 15016077 DOI: 10.1111/J.1460-9568.2004.03207.X  0.81
2004 Shaked I, Porat Z, Gersner R, Kipnis J, Schwartz M. Early activation of microglia as antigen-presenting cells correlates with T cell-mediated protection and repair of the injured central nervous system. Journal of Neuroimmunology. 146: 84-93. PMID 14698850 DOI: 10.1016/J.Jneuroim.2003.10.049  0.614
2004 Schwartz M, Kipnis J. Therapeutic T-cell-based vaccination versus pharmacological intervention for neuroprotection: Restoring lost homeostasis Drug Discovery Today: Therapeutic Strategies. 1: 281-286. DOI: 10.1016/J.Ddstr.2004.11.021  0.576
2003 Monsonego A, Beserman ZP, Kipnis J, Yoles E, Weiner HL, Schwartz M. Beneficial effect of orally administered myelin basic protein in EAE-susceptible Lewis rats in a model of acute CNS degeneration. Journal of Autoimmunity. 21: 131-8. PMID 12935782 DOI: 10.1016/S0896-8411(03)00091-X  0.547
2003 Kipnis J, Nevo U, Panikashvili D, Alexandrovich A, Yoles E, Akselrod S, Shohami E, Schwartz M. Therapeutic vaccination for closed head injury. Journal of Neurotrauma. 20: 559-69. PMID 12906740 DOI: 10.1089/089771503767168483  0.548
2003 Angelov DN, Waibel S, Guntinas-Lichius O, Lenzen M, Neiss WF, Tomov TL, Yoles E, Kipnis J, Schori H, Reuter A, Ludolph A, Schwartz M. Therapeutic vaccine for acute and chronic motor neuron diseases: implications for amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences of the United States of America. 100: 4790-5. PMID 12668759 DOI: 10.1073/Pnas.0530191100  0.501
2003 Nevo U, Kipnis J, Golding I, Shaked I, Neumann A, Akselrod S, Schwartz M. Autoimmunity as a special case of immunity: removing threats from within. Trends in Molecular Medicine. 9: 88-93. PMID 12657429 DOI: 10.1016/S1471-4914(03)00024-8  0.5
2002 Kipnis J, Mizrahi T, Hauben E, Shaked I, Shevach E, Schwartz M. Neuroprotective autoimmunity: naturally occurring CD4+CD25+ regulatory T cells suppress the ability to withstand injury to the central nervous system. Proceedings of the National Academy of Sciences of the United States of America. 99: 15620-5. PMID 12429857 DOI: 10.1073/Pnas.232565399  0.741
2002 Schwartz M, Kipnis J. Autoimmunity on alert: naturally occurring regulatory CD4(+)CD25(+) T cells as part of the evolutionary compromise between a 'need' and a 'risk'. Trends in Immunology. 23: 530-4. PMID 12401405 DOI: 10.1016/S1471-4906(02)02322-0  0.562
2002 Schwartz M, Kipnis J. Multiple sclerosis as a by-product of the failure to sustain protective autoimmunity: a paradigm shift. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 8: 405-13. PMID 12374425 DOI: 10.1177/107385802236966  0.572
2002 Kipnis J, Mizrahi T, Yoles E, Ben-Nun A, Schwartz M, Ben-Nur A. Myelin specific Th1 cells are necessary for post-traumatic protective autoimmunity. Journal of Neuroimmunology. 130: 78-85. PMID 12225890 DOI: 10.1016/S0165-5728(02)00219-9  0.75
2002 Bakalash S, Kipnis J, Yoles E, Schwartz M. Resistance of retinal ganglion cells to an increase in intraocular pressure is immune-dependent. Investigative Ophthalmology & Visual Science. 43: 2648-53. PMID 12147598  0.468
2002 Kipnis J, Schwartz M. Dual action of glatiramer acetate (Cop-1) in the treatment of CNS autoimmune and neurodegenerative disorders. Trends in Molecular Medicine. 8: 319-23. PMID 12114110 DOI: 10.1016/S1471-4914(02)02373-0  0.528
2002 Kipnis J, Mizrahi T, Yoles E, Ben-Nun A, Schwartz M. Erratum to “Myelin specific Th1 cells are necessary for post-traumatic protective autoimmunity” [J. Neuroimmunol. 130 (2002) 78–85] Journal of Neuroimmunology. 132: 196. DOI: 10.1016/S0165-5728(02)00326-0  0.708
2002 Schwartz M, Kipnis J. Prospects for therapeutic vaccination with glatiramer acetate for neurodegenerative diseases such as Alzheimer's disease Drug Development Research. 56: 143-149. DOI: 10.1002/Ddr.10069  0.542
2001 Kipnis J, Yoles E, Schori H, Hauben E, Shaked I, Schwartz M. Neuronal survival after CNS insult is determined by a genetically encoded autoimmune response. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 4564-71. PMID 11425884 DOI: 10.1523/Jneurosci.21-13-04564.2001  0.565
2001 Schwartz M, Kipnis J. Protective autoimmunity: regulation and prospects for vaccination after brain and spinal cord injuries. Trends in Molecular Medicine. 7: 252-8. PMID 11378514 DOI: 10.1016/S1471-4914(01)01993-1  0.565
2001 Schori H, Kipnis J, Yoles E, WoldeMussie E, Ruiz G, Wheeler LA, Schwartz M. Vaccination for protection of retinal ganglion cells against death from glutamate cytotoxicity and ocular hypertension: implications for glaucoma. Proceedings of the National Academy of Sciences of the United States of America. 98: 3398-403. PMID 11248090 DOI: 10.1073/Pnas.041609498  0.57
2000 Kipnis J, Yoles E, Porat Z, Cohen A, Mor F, Sela M, Cohen IR, Schwartz M. T cell immunity to copolymer 1 confers neuroprotection on the damaged optic nerve: possible therapy for optic neuropathies. Proceedings of the National Academy of Sciences of the United States of America. 97: 7446-51. PMID 10861010 DOI: 10.1073/Pnas.97.13.7446  0.549
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