| Year |
Citation |
Score |
| 2021 |
Zhang L, Misiara L, Samaranayake GJ, Sharma N, Nguyen DM, Tahara YK, Kool ET, Rai P. OGG1 co-inhibition antagonizes the tumor-inhibitory effects of targeting MTH1. Redox Biology. 40: 101848. PMID 33450725 DOI: 10.1016/j.redox.2020.101848 |
0.303 |
|
| 2019 |
Samaranayake GJ, Troccoli CI, Zhang L, Huynh M, Jayaraj CJ, Ji D, McPherson L, Onishi Y, Nguyen DM, Robbins DJ, Karbaschi M, Cooke MS, Barrientos A, Kool ET, Rai P. The existence of MTH1-independent 8-oxodGTPase activity in cancer cells as a compensatory mechanism against on-target effects of MTH1 inhibitors. Molecular Cancer Therapeutics. PMID 31744893 DOI: 10.1158/1535-7163.Mct-19-0437 |
0.384 |
|
| 2019 |
McPherson LA, Troccoli CI, Ji D, Bowles AE, Gardiner ML, Mohsen MG, Nagathihalli NS, Nguyen DM, Robbins DJ, Merchant NB, Kool ET, Rai P, Ford JM. Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue. Dna Repair. 102644. PMID 31311767 DOI: 10.1016/J.Dnarep.2019.102644 |
0.389 |
|
| 2019 |
Zhu Y, Liu J, Park J, Rai P, Zhai RG. Subcellular compartmentalization of NAD and its role in cancer: A sereNADe of metabolic melodies. Pharmacology & Therapeutics. PMID 30974124 DOI: 10.1016/J.Pharmthera.2019.04.002 |
0.357 |
|
| 2019 |
Rai P, Sobol RW. Mechanisms of MTH1 inhibition-induced DNA strand breaks: The slippery slope from the oxidized nucleotide pool to genotoxic damage. Dna Repair. 77: 18-26. PMID 30852368 DOI: 10.1016/J.Dnarep.2019.03.001 |
0.42 |
|
| 2018 |
Nagathihalli NS, Castellanos J, Lamichhane P, Messaggio F, Shi C, Dai X, Rai P, Chen X, VanSaun MN, Merchant NB. Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer. Cancer Research. PMID 30154150 DOI: 10.1158/0008-5472.Can-18-0634 |
0.331 |
|
| 2018 |
Samaranayake GJ, Troccoli CI, Huynh MQ, Lyles RDZ, Kwon D, Ban Y, Chen SX, Jorda M, Burnstein K, Rai P. Abstract B032: Inappropriate AR reactivation-induced redox stress as a novel therapeutic target in castration-resistant prostate cancer Cancer Research. 78. DOI: 10.1158/1538-7445.Prca2017-B032 |
0.331 |
|
| 2018 |
Troccoli C, Lyles R, Samaranayake G, Huynh M, Kwon D, Ban Y, Chen S, Jorda M, Sharma N, Banerjee S, Burnstein K, Rai P. The ROS duality in castration-resistant prostate cancer emergence and progression Free Radical Biology and Medicine. 128: S75. DOI: 10.1016/J.Freeradbiomed.2018.10.163 |
0.349 |
|
| 2018 |
Rai P. Towards a better understanding of human MutT Homolog 1 (MTH1) as a therapeutic target in cancer Free Radical Biology and Medicine. 128. DOI: 10.1016/J.Freeradbiomed.2018.10.157 |
0.355 |
|
| 2017 |
Samaranayake GJ, Troccoli CI, Huynh M, Lyles RDZ, Kage K, Win A, Lakshmanan V, Kwon D, Ban Y, Chen SX, Zarco ER, Jorda M, Burnstein KL, Rai P. Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer. Nature Communications. 8: 1204. PMID 29089489 DOI: 10.1038/S41467-017-01269-X |
0.315 |
|
| 2017 |
Rodriguez-Blanco J, Pednekar L, Penas C, Li B, Martin V, Long J, Lee E, Weiss WA, Rodriguez C, Mehrdad N, Nguyen DM, Ayad NG, Rai P, Capobianco AJ, Robbins DJ. Inhibition of WNT signaling attenuates self-renewal of SHH-subgroup medulloblastoma. Oncogene. PMID 28714964 DOI: 10.1038/Onc.2017.232 |
0.312 |
|
| 2017 |
Samaranayake GJ, Huynh M, Rai P. MTH1 as a Chemotherapeutic Target: The Elephant in the Room. Cancers. 9. PMID 28481306 DOI: 10.3390/Cancers9050047 |
0.377 |
|
| 2017 |
Samaranayake GJ, Troccoli CI, Cunningham TA, Rai P. Abstract A38: MTH1 Inhibition as an effective tumor-suppressive strategy in RAS-driven cancer Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Pmccavuln16-A38 |
0.366 |
|
| 2015 |
Li B, Giambelli C, Tang B, Winterbottom E, Long J, Jin K, Wang Z, Liang Fei D, Nguyen DM, Athar M, Wang B, Subbarayan PR, Wang L, Rai P, Ardalan B, et al. Arsenic Attenuates GLI Signaling, Increasing or Decreasing its Transcriptional Program in a Context Dependent Manner. Molecular Pharmacology. PMID 26573582 DOI: 10.1124/Mol.115.100867 |
0.307 |
|
| 2015 |
Giribaldi MG, Munoz A, Halvorsen K, Patel A, Rai P. MTH1 expression is required for effective transformation by oncogenic HRAS. Oncotarget. 6: 11519-29. PMID 25893378 DOI: 10.18632/Oncotarget.3447 |
0.316 |
|
| 2015 |
Patel A, Burton DG, Halvorsen K, Balkan W, Reiner T, Perez-Stable C, Cohen A, Munoz A, Giribaldi MG, Singh S, Robbins DJ, Nguyen DM, Rai P. MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways. Oncogene. 34: 2586-96. PMID 25023700 DOI: 10.1038/Onc.2014.195 |
0.407 |
|
| 2014 |
Patel A, Halvorsen K, Balkan W, Cohen A, Reiner T, Robbins D, Nguyen D, Rai P. Abstract B14: Human Mut T homolog 1 (MTH1) as a novel facilitator of KRAS-driven lung cancer Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Rasonc14-B14 |
0.38 |
|
| 2013 |
Burton DG, Giribaldi MG, Munoz A, Halvorsen K, Patel A, Jorda M, Perez-Stable C, Rai P. Androgen deprivation-induced senescence promotes outgrowth of androgen-refractory prostate cancer cells. Plos One. 8: e68003. PMID 23840802 DOI: 10.1371/Journal.Pone.0068003 |
0.319 |
|
| 2012 |
Rai P. Human Mut T Homolog 1 (MTH1): a roadblock for the tumor-suppressive effects of oncogenic RAS-induced ROS. Small Gtpases. 3: 120-5. PMID 22790201 DOI: 10.4161/Sgtp.19556 |
0.369 |
|
| 2011 |
Rai P, Young JJ, Burton DG, Giribaldi MG, Onder TT, Weinberg RA. Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence. Oncogene. 30: 1489-96. PMID 21076467 DOI: 10.1038/Onc.2010.520 |
0.352 |
|
| 2011 |
Rai P. Corrigendum to "Oxidation in the nucleotide pool, the DNA damage response and cellular senescence: Defective bricks build a defective house" [Mutation Research 703 (2010) 71-81] Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 724: 88. DOI: 10.1016/J.Mrgentox.2011.06.001 |
0.307 |
|
| 2010 |
Rai P. Oxidation in the nucleotide pool, the DNA damage response and cellular senescence: Defective bricks build a defective house. Mutation Research. 703: 71-81. PMID 20673809 DOI: 10.1016/J.Mrgentox.2010.07.010 |
0.413 |
|
| 2010 |
Young JJ, Patel A, Rai P. Suppression of thioredoxin-1 induces premature senescence in normal human fibroblasts. Biochemical and Biophysical Research Communications. 392: 363-8. PMID 20074557 DOI: 10.1016/J.Bbrc.2010.01.026 |
0.31 |
|
| 2009 |
Rai P, Onder TT, Young JJ, McFaline JL, Pang B, Dedon PC, Weinberg RA. Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Proceedings of the National Academy of Sciences of the United States of America. 106: 169-74. PMID 19118192 DOI: 10.1073/Pnas.0809834106 |
0.379 |
|
| 2007 |
Matsuda S, Fillo JD, Henry AA, Rai P, Wilkens SJ, Dwyer TJ, Geierstanger BH, Wemmer DE, Schultz PG, Spraggon G, Romesberg FE. Efforts toward expansion of the genetic alphabet: structure and replication of unnatural base pairs. Journal of the American Chemical Society. 129: 10466-73. PMID 17685517 DOI: 10.1021/Ja072276D |
0.608 |
|
| 2005 |
Rai P, Wemmer DE, Linn S. Preferential binding and structural distortion by Fe2+ at RGGG-containing DNA sequences correlates with enhanced oxidative cleavage at such sequences. Nucleic Acids Research. 33: 497-510. PMID 15659581 DOI: 10.1093/Nar/Gki192 |
0.489 |
|
| 2001 |
Rai P, Cole TD, Wemmer DE, Linn S. Localization of Fe(2+) at an RTGR sequence within a DNA duplex explains preferential cleavage by Fe(2+) and H2O2. Journal of Molecular Biology. 312: 1089-101. PMID 11580252 DOI: 10.1006/Jmbi.2001.5010 |
0.494 |
|
| 1999 |
Henle ES, Han Z, Tang N, Rai P, Luo Y, Linn S. Sequence-specific DNA cleavage by Fe2+-mediated fenton reactions has possible biological implications Journal of Biological Chemistry. 274: 962-971. PMID 9873038 DOI: 10.1074/Jbc.274.2.962 |
0.383 |
|
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