Shuibing Chen, Ph.D. - Publications

Affiliations: 
2006 Scripps Research Institute, La Jolla, La Jolla, CA, United States 

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Cook B, Walker N, Zhang Q, Chen S, Evans T. The small molecule DIPQUO promotes osteogenic differentiation via inhibition of glycogen synthase kinase 3 β signaling. The Journal of Biological Chemistry. 100696. PMID 33895139 DOI: 10.1016/j.jbc.2021.100696  0.499
2020 Pan FC, Evans T, Chen S. Modeling endodermal organ development and diseases using human pluripotent stem cell-derived organoids. Journal of Molecular Cell Biology. PMID 32652003 DOI: 10.1093/Jmcb/Mjaa031  0.306
2020 Cederquist GY, Tchieu J, Callahan SJ, Ramnarine K, Ryan S, Zhang C, Rittenhouse C, Zeltner N, Chung SY, Zhou T, Chen S, Betel D, White RM, Tomishima M, Studer L. A Multiplex Human Pluripotent Stem Cell Platform Defines Molecular and Functional Subclasses of Autism-Related Genes. Cell Stem Cell. 27: 35-49.e6. PMID 32619517 DOI: 10.1016/J.Stem.2020.06.004  0.302
2020 Yang L, Han Y, Nilsson-Payant BE, Gupta V, Wang P, Duan X, Tang X, Zhu J, Zhao Z, Jaffré F, Zhang T, Kim TW, Harschnitz O, Redmond D, Houghton S, ... ... Chen S, et al. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Cell Stem Cell. PMID 32579880 DOI: 10.1016/J.Stem.2020.06.015  0.321
2020 Ghazizadeh Z, Hurtado R, Chen S, Evans T, Tang A. Pharmacogenetics And Drug Discovery For Anthracycline-Induced Cardiotoxicity Enabled By Sinoatrial Node-Like Cells Derived From Human Pluripotent Stem Cells Journal of the American College of Cardiology. 75: 3658. DOI: 10.1016/S0735-1097(20)34285-6  0.33
2019 Tsai SY, Ghazizadeh Z, Wang HJ, Ortega FA, Badieyan ZS, Hsu ZT, Gordillo M, Kumar R, Christini DJ, Evans T, Chen S. A Human Embryonic Stem Cell Reporter Line for Monitoring Chemical-induced Cardiotoxicity. Cardiovascular Research. PMID 31173076 DOI: 10.1093/Cvr/Cvz148  0.361
2019 Li QV, Dixon G, Verma N, Rosen BP, Gordillo M, Luo R, Xu C, Wang Q, Soh CL, Yang D, Crespo M, Shukla A, Xiang Q, Dündar F, Zumbo P, ... ... Chen S, et al. Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation. Nature Genetics. PMID 31110351 DOI: 10.1038/S41588-019-0408-9  0.381
2019 Cook B, Rafiq R, Lee H, Banks KM, El-Debs M, Chiaravalli J, Glickman JF, Das BC, Chen S, Evans T. Discovery of a Small Molecule Promoting Mouse and Human Osteoblast Differentiation via Activation of p38 MAPK-β. Cell Chemical Biology. PMID 31031140 DOI: 10.1016/J.Chembiol.2019.03.009  0.315
2019 Li H, Saucedo-Cuevas L, Yuan L, Ross D, Johansen A, Sands D, Stanley V, Guemez-Gamboa A, Gregor A, Evans T, Chen S, Tan L, Molina H, Sheets N, Shiryaev SA, et al. Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors. Neuron. PMID 30713029 DOI: 10.1016/J.Neuron.2019.01.010  0.348
2019 Chen S. Abstract 476: Pharmacogenetics and Drug Discovery for Anthracycline-Induced Cardiotoxicity Enabled by Sinoatrial Node-like Cells Derived From Human Pluripotent Stem Cells Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.476  0.342
2018 Chen S. Screening-Based Chemical Approaches to Unravel Stem Cell Biology. Stem Cell Reports. 11: 1312-1323. PMID 30540959 DOI: 10.1016/J.Stemcr.2018.11.012  0.415
2018 Zhou T, Kim TW, Chong CN, Tan L, Amin S, Sadat Badieyan Z, Mukherjee S, Ghazizadeh Z, Zeng H, Guo M, Crespo M, Zhang T, Kenyon R, Robinson CL, Apostolou E, ... ... Chen S, et al. A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival. Nature Communications. 9: 4815. PMID 30446643 DOI: 10.1038/S41467-018-07201-1  0.315
2018 Amin S, Cook B, Zhou T, Ghazizadeh Z, Lis R, Zhang T, Khalaj M, Crespo M, Perera M, Xiang JZ, Zhu Z, Tomishima M, Liu C, Naji A, Evans T, ... ... Chen S, et al. Discovery of a drug candidate for GLIS3-associated diabetes. Nature Communications. 9: 2681. PMID 29992946 DOI: 10.1038/S41467-018-04918-X  0.31
2018 Mukherjee S, Zhang T, Lacko LA, Tan L, Xiang JZ, Butler JM, Chen S. Derivation and characterization of a UCP1 reporter human ES cell line. Stem Cell Research. 30: 12-21. PMID 29777802 DOI: 10.1016/J.Scr.2018.04.007  0.353
2017 Tchieu J, Zimmer B, Fattahi F, Amin S, Zeltner N, Chen S, Studer L. A Modular Platform for Differentiation of Human PSCs into All Major Ectodermal Lineages. Cell Stem Cell. 21: 399-410.e7. PMID 28886367 DOI: 10.1016/J.Stem.2017.08.015  0.402
2017 Ghazizadeh Z, Kao DI, Amin S, Cook B, Rao S, Zhou T, Zhang T, Xiang Z, Kenyon R, Kaymakcalan O, Liu C, Evans T, Chen S. ROCKII inhibition promotes the maturation of human pancreatic beta-like cells. Nature Communications. 8: 298. PMID 28824164 DOI: 10.1038/S41467-017-00129-Y  0.321
2017 Zhou T, Tan L, Cederquist GY, Fan Y, Hartley BJ, Mukherjee S, Tomishima M, Brennand KJ, Zhang Q, Schwartz RE, Evans T, Studer L, Chen S. High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain. Cell Stem Cell. PMID 28736217 DOI: 10.1016/J.Stem.2017.06.017  0.557
2017 Crespo M, Vilar E, Tsai SY, Chang K, Amin S, Srinivasan T, Zhang T, Pipalia NH, Chen HJ, Witherspoon M, Gordillo M, Xiang JZ, Maxfield FR, Lipkin S, Evans T, ... Chen S, et al. Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing. Nature Medicine. PMID 28628110 DOI: 10.1038/Nm.4355  0.368
2017 Guo M, Zhang T, Dong X, Xiang JZ, Lei M, Evans T, Graumann J, Chen S. Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E. Cell Reports. 19: 1512-1521. PMID 28538172 DOI: 10.1016/J.Celrep.2017.04.070  0.323
2017 Ghazizadeh Z, Rassouli H, Fonoudi H, Alikhani M, Talkhabi M, Darbandi-Azar A, Chen S, Baharvand H, Aghdami N, Salekdeh GH. Transient Activation of Reprogramming Transcription Factors Using Protein Transduction Facilitates Conversion of Human Fibroblasts Toward Cardiomyocyte-Like Cells. Molecular Biotechnology. PMID 28509990 DOI: 10.1007/S12033-017-0007-X  0.376
2017 Shi ZD, Lee K, Yang D, Amin S, Verma N, Li QV, Zhu Z, Soh CL, Kumar R, Evans T, Chen S, Huangfu D. Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development. Cell Stem Cell. PMID 28196600 DOI: 10.1016/J.Stem.2017.01.001  0.33
2017 Tsai SY, Chen S, Evans T. Efficient Generation of Cardiac Purkinje-like Cells from Embryonic Stem Cells by Activating cAMP Signaling. Current Protocols in Stem Cell Biology. 40: 1F.16.1-1F.16.13. PMID 28152183 DOI: 10.1002/Cpsc.20  0.417
2017 Liang H, Zheng QL, Fang P, Zhang J, Zhang T, Liu W, Guo M, Robinson CL, Chen SB, Chen XP, Chen FP, Zeng H. Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells. Scientific Reports. 7: 40361. PMID 28098170 DOI: 10.1038/Srep40361  0.304
2016 Zeng H, Guo M, Zhou T, Tan L, Chong CN, Zhang T, Dong X, Xiang JZ, Yu AS, Yue L, Qi Q, Evans T, Graumann J, Chen S. An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery. Cell Stem Cell. PMID 27524441 DOI: 10.1016/J.Stem.2016.07.002  0.304
2016 Song W, Tung CK, Lu YC, Pardo Y, Wu M, Das M, Kao DI, Chen S, Ma M. Dynamic self-organization of microwell-aggregated cellular mixtures. Soft Matter. PMID 27275624 DOI: 10.1039/C6Sm00456C  0.366
2016 Feng L, Cook B, Tsai SY, Zhou T, LaFlamme B, Evans T, Chen S. Discovery of a Small-Molecule BMP Sensitizer for Human Embryonic Stem Cell Differentiation. Cell Reports. PMID 27210748 DOI: 10.1016/J.Celrep.2016.04.066  0.402
2016 Simsek S, Zhou T, Robinson CL, Tsai SY, Crespo M, Amin S, Lin X, Hon J, Evans T, Chen S. Modeling Cystic Fibrosis Using Pluripotent Stem Cell-Derived Human Pancreatic Ductal Epithelial Cells. Stem Cells Translational Medicine. PMID 27034411 DOI: 10.5966/Sctm.2015-0276  0.361
2016 Fattahi F, Steinbeck JA, Kriks S, Tchieu J, Zimmer B, Kishinevsky S, Zeltner N, Mica Y, El-Nachef W, Zhao H, de Stanchina E, Gershon MD, Grikscheit TC, Chen S, Studer L. Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease. Nature. PMID 26863197 DOI: 10.1038/Nature16951  0.337
2015 Li C, Lin Y, Luo R, Chen S, Wang F, Zheng P, Levi M, Yang T, Wang W. Intrarenal Renin-Angiotensin System Mediates Fatty Acid-Induced ER Stress in the Kidney. American Journal of Physiology. Renal Physiology. ajprenal.00223.2015. PMID 26672616 DOI: 10.1152/ajprenal.00223.2015  0.495
2015 Wu C, Jin X, Yang J, Yang Y, He Y, Ding L, Pan Y, Chen S, Jiang J, Huang H. Inhibition of EZH2 by chemo- and radiotherapy agents and small molecule inhibitors induces cell death in castration-resistant prostate cancer. Oncotarget. PMID 26657505 DOI: 10.18632/oncotarget.6497  0.389
2015 Liu W, Zhang Z, Chen S, Ma L, Wang H, Dong R, Wang Y, Liu Z. Global transcriptome profiling analysis reveals insight into saliva-responsive genes in alfalfa. Plant Cell Reports. PMID 26645698 DOI: 10.1007/s00299-015-1903-9  0.399
2015 Si Y, Chen YB, Chen SJ, Zheng YQ, Liu X, Liu Y, Jiang HL, Xu G, Li ZH, Huang QH, Xiong H, Zhang ZG. TLR4 drives the pathogenesis of acquired cholesteatoma by promoting local inflammation and bone destruction. Scientific Reports. 5: 16683. PMID 26639190 DOI: 10.1038/srep16683  0.347
2015 Liu XL, Wang T, Huang XJ, Zhou HY, Luan XH, Shen JY, Chen SD, Cao L. Novel ATM mutations with Ataxia-Telangiectasia. Neuroscience Letters. PMID 26628246 DOI: 10.1016/j.neulet.2015.11.036  0.439
2015 Arnold CW, Oh A, Chen S, Speier W. Evaluating topic model interpretability from a primary care physician perspective. Computer Methods and Programs in Biomedicine. PMID 26614020 DOI: 10.1016/J.Cmpb.2015.10.014  0.604
2015 Liang H, Zhang L, Wang H, Tang J, Yang J, Wu C, Chen S. Inhibitory Effect of Gardenoside on Free Fatty Acid-Induced Steatosis in HepG2 Hepatocytes. International Journal of Molecular Sciences. 16: 27749-27756. PMID 26610473 DOI: 10.3390/ijms161126058  0.346
2015 Chen S, Liu L, Guo X, Yao S, Li Y, Chen S, Zhang Y, Chen W, Du Y. Effects of colonic electrical stimulation using different individual parameter patterns and stimulation sites on gastrointestinal transit time, defecation, and food intake. International Journal of Colorectal Disease. PMID 26607906 DOI: 10.1007/s00384-015-2457-6  0.318
2015 Zheng LZ, Wang XL, Cao HJ, Chen SH, Huang L, Qin L. Src siRNA prevents corticosteroid-associated osteoporosis in a rabbit model. Bone. PMID 26597781 DOI: 10.1016/J.Bone.2015.11.010  0.354
2015 Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin AR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, ... ... Chen S, et al. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Seminars in Cancer Biology. 35: S276-304. PMID 26590477 DOI: 10.1016/J.Semcancer.2015.09.007  0.474
2015 Lu X, Huang J, Mo Z, He J, Wang L, Yang X, Tan A, Chen S, Chen J, Gu CC, Chen J, Li Y, Zhao L, Li H, Hao Y, et al. Genetic Susceptibility to Lipid Levels and Lipid Change Over Time and Risk of Incident Hyperlipidemia in Chinese Populations. Circulation. Cardiovascular Genetics. PMID 26582766 DOI: 10.1161/Circgenetics.115.001096  0.437
2015 Chen S, Han M, Chen W, He Y, Huang B, Zhao P, Huang Q, Gao L, Qu X, Li X. KIF1B promotes glioma migration and invasion via cell surface localization of MT1-MMP. Oncology Reports. PMID 26576027 DOI: 10.3892/or.2015.4426  0.368
2015 Chen S, Li Y, Yao S, Zhang Y, Liu L, Guo X, Chen W, Chen Y, Du Y. Implantable Colonic Electrical Stimulation Improves Gastrointestinal Transit and Defecation in a Canine Constipation Model. Neuromodulation : Journal of the International Neuromodulation Society. PMID 26573699 DOI: 10.1111/ner.12369  0.319
2015 Chen S, Cao L, Huang Q, Qian Y, Zhou X. The complete genome sequence of a novel maize-associated totivirus. Archives of Virology. PMID 26559960 DOI: 10.1007/s00705-015-2657-y  0.387
2015 Aad G, Abbott B, Abdallah J, Abdinov O, Aben R, Abolins M, AbouZeid OS, Abramowicz H, Abreu H, Abreu R, Abulaiti Y, Acharya BS, Adamczyk L, Adams DL, ... Chen S, et al. Search for metastable heavy charged particles with large ionisation energy loss in pp collisions at [Formula: see text] TeV using the ATLAS experiment. The European Physical Journal. C, Particles and Fields. 75: 407. PMID 26543401 DOI: 10.1140/Epjc/S10052-015-3609-0  0.471
2015 Jia B, Shi Y, Kang S, Yang S, Hu S, Li Y, Dong M, Wang W, Yang J, Zhou L, Liu P, Zhou S, Qin Y, Gui L, Zhang C, ... ... Chen S, et al. Addition of rituximab is not associated with survival benefit compared with CHOP alone for patients with stage I diffuse large B-cell lymphoma. Chinese Journal of Cancer Research = Chung-Kuo Yen Cheng Yen Chiu. 27: 516-23. PMID 26543339 DOI: 10.3978/j.issn.1000-9604.2015.10.04  0.307
2015 Arnold CW, Wallace WD, Chen S, Oh A, Abtin F, Genshaft S, Binder S, Aberle D, Enzmann D. RadPath:: A Web-based System for Integrating and Correlating Radiology and Pathology Findings During Cancer Diagnosis. Academic Radiology. PMID 26521686 DOI: 10.1016/J.Acra.2015.09.009  0.615
2015 Kulkarni A, Zeng Y, Zhou W, Van Lanen S, Zhang W, Chen S. A branch point of Streptomyces sulfur amino acid metabolism controls the production of albomycin. Applied and Environmental Microbiology. PMID 26519385 DOI: 10.1128/Aem.02517-15  0.638
2015 Wang H, Huang Q, Shi Q, Yue T, Chen S, Nakajima M, Takeuchi M, Fukuda T. Automated Assembly of Vascular-Like Microtube With Repetitive Single-Step Contact Manipulation. Ieee Transactions On Bio-Medical Engineering. 62: 2620-8. PMID 26513766 DOI: 10.1109/TBME.2015.2437952  0.364
2015 Huang Q, Zhou C, Chen X, Dong B, Chen S, Zhang N, Liu Y, Li A, Yao M, Miao J, Li Q, Wang Z. Prodrug AST-003 Improves the Therapeutic Index of the Multi-Targeted Tyrosine Kinase Inhibitor Sunitinib. Plos One. 10: e0141395. PMID 26513662 DOI: 10.1371/Journal.Pone.0141395  0.374
2015 Tsai SY, Maass K, Lu J, Fishman GI, Chen S, Evans T. Efficient Generation of Cardiac Purkinje Cells from ESCs by Activating cAMP Signaling. Stem Cell Reports. 4: 1089-102. PMID 26028533 DOI: 10.1016/J.Stemcr.2015.04.015  0.381
2015 Kao DI, Lacko LA, Ding BS, Huang C, Phung K, Gu G, Rafii S, Stuhlmann H, Chen S. Endothelial cells control pancreatic cell fate at defined stages through EGFL7 signaling. Stem Cell Reports. 4: 181-9. PMID 25601205 DOI: 10.1016/J.Stemcr.2014.12.008  0.357
2012 Kao DI, Chen S. Pluripotent stem cell-derived pancreatic β-cells: potential for regenerative medicine in diabetes. Regenerative Medicine. 7: 583-93. PMID 22817630 DOI: 10.2217/Rme.12.27  0.348
2009 Maehr R, Chen S, Snitow M, Ludwig T, Yagasaki L, Goland R, Leibel RL, Melton DA. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences of the United States of America. 106: 15768-73. PMID 19720998 DOI: 10.1073/Pnas.0906894106  0.363
2009 Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell. 4: 348-58. PMID 19341624 DOI: 10.1016/J.Stem.2009.01.014  0.419
2009 Chen S, Borowiak M, Fox JL, Maehr R, Osafune K, Davidow L, Lam K, Peng LF, Schreiber SL, Rubin LL, Melton D. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nature Chemical Biology. 5: 258-65. PMID 19287398 DOI: 10.1038/Nchembio.154  0.388
2008 Huangfu D, Osafune K, Maehr R, Guo W, Eijkelenboom A, Chen S, Muhlestein W, Melton DA. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nature Biotechnology. 26: 1269-75. PMID 18849973 DOI: 10.1038/Nbt.1502  0.407
2008 Supekova L, Supek F, Lee J, Chen S, Gray N, Pezacki JP, Schlapbach A, Schultz PG. Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening. The Journal of Biological Chemistry. 283: 29-36. PMID 17951261 DOI: 10.1074/Jbc.M703988200  0.726
2007 Qyang Y, Martin-Puig S, Chiravuri M, Chen S, Xu H, Bu L, Jiang X, Lin L, Granger A, Moretti A, Caron L, Wu X, Clarke J, Taketo MM, Laugwitz KL, et al. The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell. 1: 165-79. PMID 18371348 DOI: 10.1016/J.Stem.2007.05.018  0.581
2007 Chen S, Takanashi S, Zhang Q, Xiong W, Zhu S, Peters EC, Ding S, Schultz PG. Reversine increases the plasticity of lineage-committed mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 10482-7. PMID 17566101 DOI: 10.1073/Pnas.0704360104  0.746
2007 Chen S, Schultz PG, Brock A. An improved system for the generation and analysis of mutant proteins containing unnatural amino acids in Saccharomyces cerevisiae. Journal of Molecular Biology. 371: 112-22. PMID 17560600 DOI: 10.1016/J.Jmb.2007.05.017  0.747
2007 Liu W, Brock A, Chen S, Chen S, Schultz PG. Genetic incorporation of unnatural amino acids into proteins in mammalian cells. Nature Methods. 4: 239-44. PMID 17322890 DOI: 10.1038/nmeth1016  0.757
2006 Chen S, Do JT, Zhang Q, Yao S, Yan F, Peters EC, Schöler HR, Schultz PG, Ding S. Self-renewal of embryonic stem cells by a small molecule. Proceedings of the National Academy of Sciences of the United States of America. 103: 17266-71. PMID 17088537 DOI: 10.1073/Pnas.0608156103  0.744
2006 Chen S, Hilcove S, Ding S. Exploring stem cell biology with small molecules. Molecular Biosystems. 2: 18-24. PMID 16880919 DOI: 10.1039/B512000B  0.563
2006 Summerer D, Chen S, Wu N, Deiters A, Chin JW, Schultz PG. A genetically encoded fluorescent amino acid. Proceedings of the National Academy of Sciences of the United States of America. 103: 9785-9. PMID 16785423 DOI: 10.1073/Pnas.0603965103  0.725
2006 Yao S, Chen S, Clark J, Hao E, Beattie GM, Hayek A, Ding S. Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions. Proceedings of the National Academy of Sciences of the United States of America. 103: 6907-12. PMID 16632596 DOI: 10.1073/Pnas.0602280103  0.765
2004 Chen S, Zhang Q, Wu X, Schultz PG, Ding S. Dedifferentiation of lineage-committed cells by a small molecule. Journal of the American Chemical Society. 126: 410-1. PMID 14719906 DOI: 10.1021/Ja037390K  0.753
1995 Xiang XD, Sun X, Briceño G, Lou Y, Wang KA, Chang H, Wallace-Freedman WG, Chen SW, Schultz PG. A combinatorial approach to materials discovery. Science (New York, N.Y.). 268: 1738-40. PMID 17834993 DOI: 10.1126/Science.268.5218.1738  0.63
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