David Pincus, Ph.D. - Publications

Affiliations: 
2012 Cell Biology University of California, San Francisco, San Francisco, CA 
Area:
Secretion, UPR

42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Pincus D, Oakes SA. Unfolding emergency calls stress granules to the ER. Nature Cell Biology. PMID 38822214 DOI: 10.1038/s41556-024-01434-7  0.326
2024 Garde R, Dea A, Herwig MF, Pincus D. Feedback control of the heat shock response by spatiotemporal regulation of Hsp70. Biorxiv : the Preprint Server For Biology. PMID 38260373 DOI: 10.1101/2024.01.09.574867  0.35
2023 Ali A, Garde R, Schaffer OC, Bard JAM, Husain K, Kik SK, Davis KA, Luengo-Woods S, Igarashi MG, Drummond DA, Squires AH, Pincus D. Adaptive preservation of orphan ribosomal proteins in chaperone-dispersed condensates. Nature Cell Biology. PMID 37845327 DOI: 10.1038/s41556-023-01253-2  0.342
2023 Garde R, Singh A, Ali A, Pincus D. Transcriptional regulation of Sis1 promotes fitness but not feedback in the heat shock response. Elife. 12. PMID 37158601 DOI: 10.7554/eLife.79444  0.328
2021 Kainth AS, Chowdhary S, Pincus D, Gross DS. Primordial super-enhancers: heat shock-induced chromatin organization in yeast. Trends in Cell Biology. PMID 34001402 DOI: 10.1016/j.tcb.2021.04.004  0.314
2020 Tsvetkov P, Eisen TJ, Heinrich SU, Brune Z, Hallacli E, Newby GA, Kayatekin C, Pincus D, Lindquist S. Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition. Cell Reports. 32: 108001. PMID 32783929 DOI: 10.1016/J.Celrep.2020.108001  0.414
2020 Pincus D. Regulation of Hsf1 and the Heat Shock Response. Advances in Experimental Medicine and Biology. 1243: 41-50. PMID 32297210 DOI: 10.1007/978-3-030-40204-4_3  0.441
2020 Mace K, Krakowiak J, El-Samad H, Pincus D. Multi-kinase control of environmental stress responsive transcription. Plos One. 15: e0230246. PMID 32160258 DOI: 10.1371/Journal.Pone.0230246  0.692
2019 McCormick JW, Pincus D, Resnekov O, Reynolds KA. Strategies for Engineering and Rewiring Kinase Regulation. Trends in Biochemical Sciences. PMID 31866305 DOI: 10.1016/J.Tibs.2019.11.005  0.405
2019 Bushkin GG, Pincus D, Morgan JT, Richardson K, Lewis C, Chan SH, Bartel DP, Fink GR. mA modification of a 3' UTR site reduces RME1 mRNA levels to promote meiosis. Nature Communications. 10: 3414. PMID 31363087 DOI: 10.1038/S41467-019-11232-7  0.324
2019 Tye BW, Commins N, Ryazanova LV, Wühr M, Springer M, Pincus D, Churchman LS. Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness. Elife. 8. PMID 30843788 DOI: 10.7554/Elife.43002  0.373
2019 Chowdhary S, Kainth AS, Pincus D, Gross DS. Heat Shock Factor 1 Drives Intergenic Association of Its Target Gene Loci upon Heat Shock. Cell Reports. 26: 18-28.e5. PMID 30605674 DOI: 10.1016/J.Celrep.2018.12.034  0.382
2019 Morano K, Pincus D. Decision letter: Cytoplasmic protein misfolding titrates Hsp70 to activate nuclear Hsf1 Elife. DOI: 10.7554/Elife.47791.028  0.358
2018 Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, ... ... Pincus D, et al. Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Molecular Cell. PMID 30527540 DOI: 10.1016/J.Molcel.2018.11.028  0.531
2018 Pincus D, Pandey JP, Feder ZA, Creixell P, Resnekov O, Reynolds KA. Engineering allosteric regulation in protein kinases. Science Signaling. 11. PMID 30401787 DOI: 10.1126/Scisignal.Aar3250  0.405
2018 Pincus D, Anandhakumar J, Thiru P, Guertin MJ, Erkine AM, Gross DS. Genetic and epigenetic determinants establish a continuum of Hsf1 occupancy and activity across the yeast genome. Molecular Biology of the Cell. mbcE18060353. PMID 30332327 DOI: 10.1091/Mbc.E18-06-0353  0.354
2018 Creixell P, Pandey JP, Palmeri A, Bhattacharyya M, Creixell M, Ranganathan R, Pincus D, Yaffe MB. Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity. Cell Systems. PMID 30243563 DOI: 10.1016/J.Cels.2018.08.008  0.328
2018 Truttmann MC, Pincus D, Ploegh HL. Chaperone AMPylation modulates aggregation and toxicity of neurodegenerative disease-associated polypeptides. Proceedings of the National Academy of Sciences of the United States of America. PMID 29760078 DOI: 10.1073/Pnas.1801989115  0.37
2018 Zheng X, Beyzavi A, Krakowiak J, Patel N, Khalil AS, Pincus D. Hsf1 Phosphorylation Generates Cell-to-Cell Variation in Hsp90 Levels and Promotes Phenotypic Plasticity. Cell Reports. 22: 3099-3106. PMID 29562166 DOI: 10.1016/J.Celrep.2018.02.083  0.339
2018 Krakowiak J, Zheng X, Patel N, Feder ZA, Anandhakumar J, Valerius K, Gross DS, Khalil AS, Pincus D. Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response. Elife. 7. PMID 29393852 DOI: 10.7554/Elife.31668  0.368
2018 Pincus D. Decision letter: The proteasome biogenesis regulator Rpn4 cooperates with the unfolded protein response to promote ER stress resistance Elife. DOI: 10.7554/Elife.43244.027  0.46
2017 Pincus D, Resnekov O, Reynolds K. An evolution-based strategy for engineering allosteric regulation. Physical Biology. PMID 28266924 DOI: 10.1088/1478-3975/Aa64A4  0.397
2016 Truttmann MC, Zheng X, Hanke L, Damon JR, Grootveld M, Krakowiak J, Pincus D, Ploegh HL. Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response. Proceedings of the National Academy of Sciences of the United States of America. PMID 28031489 DOI: 10.1073/Pnas.1619234114  0.439
2016 Zheng X, Krakowiak J, Patel N, Beyzavi A, Ezike J, Khalil AS, Pincus D. Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation. Elife. 5. PMID 27831465 DOI: 10.7554/Elife.18638  0.439
2016 Pincus D. Size doesn't matter in the heat shock response. Current Genetics. PMID 27502399 DOI: 10.1007/S00294-016-0638-7  0.387
2016 Zheng X, Krakowiak J, Patel N, Beyzavi A, Ezike J, Khalil AS, Pincus D. Author response: Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation Elife. DOI: 10.7554/Elife.18638.027  0.306
2015 Damon JR, Pincus D, Ploegh HL. tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae. Molecular Biology of the Cell. 26: 270-82. PMID 25392298 DOI: 10.1091/Mbc.E14-06-1145  0.463
2014 van Anken E, Pincus D, Coyle S, Aragón T, Osman C, Lari F, Gómez Puerta S, Korennykh AV, Walter P. Specificity in endoplasmic reticulum-stress signaling in yeast entails a step-wise engagement of HAC1 mRNA to clusters of the stress sensor Ire1. Elife. 3: e05031. PMID 25549299 DOI: 10.7554/Elife.05031  0.706
2014 Pincus D, Aranda-Díaz A, Zuleta IA, Walter P, El-Samad H. Delayed Ras/PKA signaling augments the unfolded protein response. Proceedings of the National Academy of Sciences of the United States of America. 111: 14800-5. PMID 25275008 DOI: 10.1073/Pnas.1409588111  0.747
2013 Pincus D, Ryan CJ, Smith RD, Brent R, Resnekov O. Assigning quantitative function to post-translational modifications reveals multiple sites of phosphorylation that tune yeast pheromone signaling output. Plos One. 8: e56544. PMID 23554854 DOI: 10.1371/Journal.Pone.0056544  0.398
2013 Vidal SE, Pincus D, Stewart-Ornstein J, El-Samad H. Formation of subnuclear foci is a unique spatial behavior of mating MAPKs during hyperosmotic stress. Cell Reports. 3: 328-34. PMID 23416049 DOI: 10.1016/J.Celrep.2013.01.022  0.683
2013 Gardner BM, Pincus D, Gotthardt K, Gallagher CM, Walter P. Endoplasmic reticulum stress sensing in the unfolded protein response. Cold Spring Harbor Perspectives in Biology. 5: a013169. PMID 23388626 DOI: 10.1101/Cshperspect.A013169  0.738
2012 Fordyce PM, Pincus D, Kimmig P, Nelson CS, El-Samad H, Walter P, DeRisi JL. Basic leucine zipper transcription factor Hac1 binds DNA in two distinct modes as revealed by microfluidic analyses. Proceedings of the National Academy of Sciences of the United States of America. 109: E3084-93. PMID 23054834 DOI: 10.1073/Pnas.1212457109  0.673
2012 Pincus D, Walter P. A first line of defense against ER stress. The Journal of Cell Biology. 198: 277-9. PMID 22869593 DOI: 10.1083/Jcb.201207076  0.572
2011 Thomson TM, Benjamin KR, Bush A, Love T, Pincus D, Resnekov O, Yu RC, Gordon A, Colman-Lerner A, Endy D, Brent R. Scaffold number in yeast signaling system sets tradeoff between system output and dynamic range. Proceedings of the National Academy of Sciences of the United States of America. 108: 20265-70. PMID 22114196 DOI: 10.1073/Pnas.1004042108  0.409
2011 Milias-Argeitis A, Summers S, Stewart-Ornstein J, Zuleta I, Pincus D, El-Samad H, Khammash M, Lygeros J. In silico feedback for in vivo regulation of a gene expression circuit. Nature Biotechnology. 29: 1114-6. PMID 22057053 DOI: 10.1038/Nbt.2018  0.671
2011 Rubio C, Pincus D, Korennykh A, Schuck S, El-Samad H, Walter P. Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity. The Journal of Cell Biology. 193: 171-84. PMID 21444684 DOI: 10.1083/Jcb.201007077  0.772
2010 Pincus D, Chevalier MW, Aragón T, van Anken E, Vidal SE, El-Samad H, Walter P. BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response. Plos Biology. 8: e1000415. PMID 20625545 DOI: 10.1371/Journal.Pbio.1000415  0.77
2010 Pincus D, Benjamin K, Burbulis I, Tsong AE, Resnekov O. Reagents for investigating MAPK signalling in model yeast species. Yeast (Chichester, England). 27: 423-30. PMID 20162536 DOI: 10.1002/Yea.1758  0.411
2009 Aragón T, van Anken E, Pincus D, Serafimova IM, Korennykh AV, Rubio CA, Walter P. Messenger RNA targeting to endoplasmic reticulum stress signalling sites. Nature. 457: 736-40. PMID 19079237 DOI: 10.1038/Nature07641  0.76
2008 Yu RC, Pesce CG, Colman-Lerner A, Lok L, Pincus D, Serra E, Holl M, Benjamin K, Gordon A, Brent R. Negative feedback that improves information transmission in yeast signalling. Nature. 456: 755-61. PMID 19079053 DOI: 10.1038/Nature07513  0.562
2008 Pincus D, Letunic I, Bork P, Lim WA. Evolution of the phospho-tyrosine signaling machinery in premetazoan lineages. Proceedings of the National Academy of Sciences of the United States of America. 105: 9680-4. PMID 18599463 DOI: 10.1073/Pnas.0803161105  0.316
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