| Year |
Citation |
Score |
| 2024 |
Montalvo MJ, Bandey IN, Rezvan A, Wu KL, Saeedi A, Kulkarni R, Li Y, An X, Sefat KMSR, Varadarajan N. Decoding the mechanisms of chimeric antigen receptor (CAR) T cell-mediated killing of tumors: insights from granzyme and Fas inhibition. Cell Death & Disease. 15: 109. PMID 38307835 DOI: 10.1038/s41419-024-06461-8 |
0.342 |
|
| 2022 |
Romain G, Strati P, Rezvan A, Fathi M, Bandey IN, Adolacion JR, Heeke DS, Liadi I, Marques-Piubelli ML, Solis Soto LM, Mahendra A, Vega F, Cooper LJ, Singh H, Mattie M, ... ... Varadarajan N, et al. Multidimensional single-cell analysis identifies a role for CD2-CD58 interactions in clinical antitumor T cell responses. The Journal of Clinical Investigation. PMID 35881486 DOI: 10.1172/JCI159402 |
0.309 |
|
| 2021 |
Bandey IN, Adolacion JRT, Romain G, Paniagua MM, An X, Saeedi A, Liadi I, You Z, Rajanayake RB, Hwu P, Singh H, Cooper LJ, Varadarajan N. Designed improvement to T-cell immunotherapy by multidimensional single cell profiling. Journal For Immunotherapy of Cancer. 9. PMID 33722906 DOI: 10.1136/jitc-2020-001877 |
0.3 |
|
| 2020 |
Rath JA, Bajwa G, Carreres B, Hoyer E, Gruber I, Martínez-Paniagua MA, Yu YR, Nouraee N, Sadeghi F, Wu M, Wang T, Hebeisen M, Rufer N, Varadarajan N, Ho PC, et al. Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4 T cells. Science Advances. 6: eaaz7809. PMID 32923584 DOI: 10.1126/Sciadv.Aaz7809 |
0.417 |
|
| 2020 |
Daher M, Basar R, Gokdemir E, Baran N, Uprety N, Nunez Cortes AK, Mendt M, Kerbauy LN, Banerjee PP, Hernandez Sanabria M, Imahashi N, Li L, Lim FLWIL, Fathi M, Rezvan A, ... ... Varadarajan N, et al. Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells. Blood. PMID 32902645 DOI: 10.1182/Blood.2020007748 |
0.346 |
|
| 2020 |
Doshi A, Sadeghi F, Varadarajan N, Cirino PC. Small-molecule inducible transcriptional control in mammalian cells. Critical Reviews in Biotechnology. 1-20. PMID 32862714 DOI: 10.1080/07388551.2020.1808583 |
0.306 |
|
| 2020 |
Fousek K, Watanabe J, Joseph SK, George A, An X, Byrd TT, Morris JS, Luong A, Martínez-Paniagua MA, Sanber K, Navai SA, Gad AZ, Salsman VS, Mathew PR, Kim HN, ... ... Varadarajan N, et al. CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression. Leukemia. PMID 32205861 DOI: 10.1038/S41375-020-0792-2 |
0.364 |
|
| 2019 |
Ramesh B, Abnouf S, Mali S, Moree WJ, Patil U, Bark SJ, Varadarajan N. Engineered ChymotrypsiN for Mass Spectrometry-Based Detection of Protein Glycosylation. Acs Chemical Biology. PMID 31710461 DOI: 10.1021/Acschembio.9B00506 |
0.403 |
|
| 2019 |
Liadi I, Singh H, Romain G, Roysam B, Cooper LJ, Varadarajan N. Defining potency of CAR T cells: Fast and furious or slow and steady. Oncoimmunology. 8: e1051298. PMID 31646063 DOI: 10.1080/2162402X.2015.1051298 |
0.445 |
|
| 2019 |
An X, Adolacion JR, Alfayez M, Matthews J, Flores W, Kornblau SM, Saeedi A, Basu S, Daver NG, Varadarajan N. Single-Cell Deconvolution Identifies T-Cell Correlates of Response to PD-1 Blockade Treatment in AML Blood. 134: 1950-1950. DOI: 10.1182/Blood-2019-122081 |
0.394 |
|
| 2019 |
Joseph R, Soundararajan R, Vasaikar S, Yang F, Isgandarova S, Tian L, Haemmerle M, Mino B, Zhou T, Raja GV, Pena ER, Hollander PD, Bhangre N, Shin C, Martinez M, ... ... Varadarajan N, et al. Abstract 3761: Regulation of metastasis by CD8 T lymphocytes Cancer Research. 79: 3761-3761. DOI: 10.1158/1538-7445.Am2019-3761 |
0.331 |
|
| 2019 |
Fathi M, Joseph R, Martinez-Paniagua M, Adolacion JR, An X, Mahendra A, Gabrusiewicz K, Chatterjee S, Mani SA, Varadarajan N. Abstract 2907: Exosome secretion is an inheritable property of cancer cells: Single-cell profiling of exosome secretion Cancer Research. 79: 2907-2907. DOI: 10.1158/1538-7445.Am2019-2907 |
0.393 |
|
| 2018 |
An X, Varadarajan N. Single-cell technologies for profiling T cells to enable monitoring of immunotherapies. Current Opinion in Chemical Engineering. 19: 142-152. PMID 31131208 DOI: 10.1016/J.Coche.2018.01.003 |
0.392 |
|
| 2018 |
Lu H, Li J, Martinez Paniagua MA, Bandey IN, Amritkar A, Singh H, Mayerich D, Varadarajan N, Roysam B. TIMING 2.0: High-throughput single-cell profiling of dynamic cell-cell interactions by time-lapse imaging microscopy in nanowell grids. Bioinformatics (Oxford, England). PMID 30084956 DOI: 10.1093/Bioinformatics/Bty676 |
0.333 |
|
| 2018 |
Fousek K, Watanabe J, George A, An X, Samaha HS, Navai SA, Byrd TT, Jang A, Kim HN, Joseph S, Baker M, Varadarajan N, Hegde MG, Kim Y, Heisterkamp N, et al. Targeting CD19-negative relapsed B-acute lymphoblastic leukemia using trivalent CAR T cells. Journal of Clinical Oncology. 36: 121-121. DOI: 10.1200/Jco.2018.36.5_Suppl.121 |
0.385 |
|
| 2018 |
Fousek K, Watanabe J, An X, George A, Samaha H, Navai S, Byrd TT, Kirzner J, Kim HN, Jang A, Joseph S, Baker M, Hegde M, Varadarajan N, Heisterkamp N, et al. Abstract A50: Trivalent CAR T cells mitigate CD19-negative relapse and improve tumor control in primary pre-B cell acute lymphoblastic leukemia (B-ALL) Cancer Immunology Research. 6. DOI: 10.1158/2326-6074.Tumimm17-A50 |
0.387 |
|
| 2017 |
An X, Sendra VG, Liadi I, Ramesh B, Romain G, Haymaker C, Martinez-Paniagua M, Lu Y, Radvanyi LG, Roysam B, Varadarajan N. Single-cell profiling of dynamic cytokine secretion and the phenotype of immune cells. Plos One. 12: e0181904. PMID 28837583 DOI: 10.1371/Journal.Pone.0181904 |
0.393 |
|
| 2017 |
Ritthipichai K, Haymaker C, Martinez-Paniagua M, Aschenbrenner A, Yi X, Zhang M, Kale C, Hailemichael Y, Overwijk WW, Vence L, Roszik J, Varadarajan N, Nurieva R, Radvanyi LG, Hwu P, et al. Multifaceted role of BTLA in the control of CD8+ T cell fate after antigen encounter. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28754817 DOI: 10.1158/1078-0432.Ccr-16-1217 |
0.397 |
|
| 2017 |
Varadarajan N. Unmassked: Single-Cell Profiling of Immune Cell Populations in Tumors. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28684257 DOI: 10.1016/J.Ymthe.2017.06.024 |
0.361 |
|
| 2017 |
Lee CH, Romain G, Yan W, Watanabe M, Charab W, Todorova B, Lee J, Triplett K, Donkor M, Lungu OI, Lux A, Marshall N, Lindorfer MA, Goff OR, Balbino B, ... ... Varadarajan N, et al. IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions. Nature Immunology. PMID 28604720 DOI: 10.1038/Ni.3770 |
0.351 |
|
| 2017 |
Fousek K, Watanabe J, George A, An X, Samaha H, Navai SA, Byrd TT, Jang A, Kim HN, Joseph S, Baker M, Varadarajan N, Hegde MG, Kim Y, Heisterkamp N, et al. Targeting Primary Pre-B Cell Acute Lymphoblastic Leukemia and CD19-Negative Relapses Using Trivalent CAR T Cells Blood. 130: 4614-4614. DOI: 10.1182/Blood.V130.Suppl_1.4614.4614 |
0.394 |
|
| 2016 |
Moogk D, Zhong S, Yu Z, Liadi I, Rittase W, Fang V, Dougherty J, Perez-Garcia A, Osman I, Zhu C, Varadarajan N, Restifo NP, Frey AB, Krogsgaard M. Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets. Journal of Immunology (Baltimore, Md. : 1950). PMID 27271569 DOI: 10.4049/Jimmunol.1600178 |
0.356 |
|
| 2016 |
Romain G, Singh H, Liadi I, Adolacion JR, Cooper LJN, Varadarajan N. Abstract B082: Migratory T cells demonstrate superior persistence and enhanced tumor control Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-B082 |
0.444 |
|
| 2016 |
Singh H, Huls MH, Figliola MJ, Zhang L, Mi T, Maiti S, Romain G, Olivares S, Su S, Hurton LV, Varadarajan N, Cooper LJ, Kebriaei P. 278. Next-Generation Non-Viral Gene Transfer to Redirect T-Cell Specificity Molecular Therapy. 24: S110-S111. DOI: 10.1016/S1525-0016(16)33087-8 |
0.411 |
|
| 2015 |
Merouane A, Rey-Villamizar N, Lu Y, Liadi I, Romain G, Lu J, Singh H, Cooper LJ, Varadarajan N, Roysam B. Automated profiling of individual cell-cell interactions from high-throughput time-lapse imaging microscopy in nanowell grids (TIMING). Bioinformatics (Oxford, England). PMID 26059718 DOI: 10.1093/Bioinformatics/Btv355 |
0.357 |
|
| 2015 |
Liadi I, Singh H, Romain G, Rey-Villamizar N, Merouane A, Adolacion JR, Kebriaei P, Huls H, Qiu P, Roysam B, Cooper LJ, Varadarajan N. Individual Motile CD4(+) T Cells Can Participate in Efficient Multikilling through Conjugation to Multiple Tumor Cells. Cancer Immunology Research. 3: 473-82. PMID 25711538 DOI: 10.1158/2326-6066.Cir-14-0195 |
0.437 |
|
| 2015 |
Martinez-Paniagua M, Haymaker C, Adolacion JR, Radvanyi L, Hwu P, Roysam B, Bernatchez C, Varadarajan N. Single-cell motility and gene expression signature as predictors of the overall survival of act in melanoma patients Journal For Immunotherapy of Cancer. 3. DOI: 10.1186/2051-1426-3-S2-P33 |
0.371 |
|
| 2015 |
Romain G, Singh H, Liadi I, Adolacion JR, Roysam B, Cooper L, Varadarajan N. Single cell metrics of the efficacy of CAR T cells Journal For Immunotherapy of Cancer. 3. DOI: 10.1186/2051-1426-3-S2-P324 |
0.44 |
|
| 2014 |
Ramesh B, Frei CS, Cirino PC, Varadarajan N. Functional enrichment by direct plasmid recovery after fluorescence activated cell sorting. Biotechniques. 59: 157-61. PMID 26345509 DOI: 10.2144/000114329 |
0.367 |
|
| 2014 |
Romain G, Senyukov V, Rey-Villamizar N, Merouane A, Kelton W, Liadi I, Mahendra A, Charab W, Georgiou G, Roysam B, Lee DA, Varadarajan N. Antibody Fc engineering improves frequency and promotes kinetic boosting of serial killing mediated by NK cells. Blood. 124: 3241-9. PMID 25232058 DOI: 10.1182/Blood-2014-04-569061 |
0.385 |
|
| 2014 |
Ogunniyi AO, Thomas BA, Politano TJ, Varadarajan N, Landais E, Poignard P, Walker BD, Kwon DS, Love JC. Profiling human antibody responses by integrated single-cell analysis. Vaccine. 32: 2866-73. PMID 24602776 DOI: 10.1016/J.Vaccine.2014.02.020 |
0.354 |
|
| 2014 |
Varadarajan N, Liadi I, Romain G, Singh H, Cooper L. Functional and molecular characterization of single serial killer CAR+ T cells demonstrates adaptive modification of behavior and fate based on tumor cell density Journal For Immunotherapy of Cancer. 2. DOI: 10.1186/2051-1426-2-S3-P145 |
0.438 |
|
| 2014 |
Varadarajan N, Cooper LJ, Ivan L, Singh H, Roysam B, Gabrielle R, Amin M. Functional and Molecular Characterization of Serial Killer CAR+ T Cells Demonstrates Adaptive Modification of Fate and Behavior Based on Tumor Cell Density Blood. 124: 658-658. DOI: 10.1182/Blood.V124.21.658.658 |
0.439 |
|
| 2014 |
Singh H, Liadi I, Romain G, Varadarajan N, Cooper LJ. Evaluating the Effector Function of Individual CD19-Specific T Cells to Assess the Therapeutic Impact of a Manufactured Product Biology of Blood and Marrow Transplantation. 20: S134-S135. DOI: 10.1016/J.Bbmt.2013.12.207 |
0.352 |
|
| 2013 |
Sendra VG, Lie A, Romain G, Agarwal SK, Varadarajan N. Detection and isolation of auto-reactive human antibodies from primary B cells. Methods (San Diego, Calif.). 64: 153-9. PMID 23811296 DOI: 10.1016/J.Ymeth.2013.06.018 |
0.366 |
|
| 2013 |
Liadi I, Roszik J, Romain G, Cooper LJ, Varadarajan N. Quantitative high-throughput single-cell cytotoxicity assay for T cells. Journal of Visualized Experiments : Jove. e50058. PMID 23407457 DOI: 10.3791/50058 |
0.426 |
|
| 2013 |
DeKosky BJ, Ippolito GC, Deschner RP, Lavinder JJ, Wine Y, Rawlings BM, Varadarajan N, Giesecke C, Dörner T, Andrews SF, Wilson PC, Hunicke-Smith SP, Willson CG, Ellington AD, Georgiou G. High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire. Nature Biotechnology. 31: 166-9. PMID 23334449 DOI: 10.1038/Nbt.2492 |
0.311 |
|
| 2013 |
Liadi I, Singh H, Romain G, Rey-Villamizar N, Merouane A, Roysam B, Cooper LJ, Varadarajan N. Quantitative single-cell characterization of CAR+ T cell effector functions Journal For Immunotherapy of Cancer. 1: P36. DOI: 10.1186/2051-1426-1-S1-P36 |
0.443 |
|
| 2013 |
Romain G, Senyukov VV, Liadi I, Kelton W, Georgiou G, Lee DA, Varadarajan N. Single-cell quantification of functional outcomes of CD16 ligation in NK cells by Fc-engineered antibodies Journal For Immunotherapy of Cancer. 1. DOI: 10.1186/2051-1426-1-S1-O5 |
0.413 |
|
| 2013 |
Varadarajan N, Liadi I, Romain G, Singh H, Cooper LJN. Abstract 4745: Quantitative single-cell functional characterization of CD19-specific CAR+ T Cells for immunotherapy. Cancer Research. 73: 4745-4745. DOI: 10.1158/1538-7445.Am2013-4745 |
0.447 |
|
| 2012 |
Ramesh B, Sendra VG, Cirino PC, Varadarajan N. Single-cell characterization of autotransporter-mediated Escherichia coli surface display of disulfide bond-containing proteins. The Journal of Biological Chemistry. 287: 38580-9. PMID 23019324 DOI: 10.1074/Jbc.M112.388199 |
0.339 |
|
| 2012 |
Skretas G, Makino T, Varadarajan N, Pogson M, Georgiou G. Multi-copy genes that enhance the yield of mammalian G protein-coupled receptors in Escherichia coli. Metabolic Engineering. 14: 591-602. PMID 22609824 DOI: 10.1016/J.Nbt.2012.08.406 |
0.303 |
|
| 2012 |
Varadarajan N, Kwon DS, Law KM, Ogunniyi AO, Anahtar MN, Richter JM, Walker BD, Love JC. Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving. Proceedings of the National Academy of Sciences of the United States of America. 109: 3885-90. PMID 22355106 DOI: 10.1073/Pnas.1111205109 |
0.43 |
|
| 2011 |
Varadarajan N, Julg B, Yamanaka YJ, Chen H, Ogunniyi AO, McAndrew E, Porter LC, Piechocka-Trocha A, Hill BJ, Douek DC, Pereyra F, Walker BD, Love JC. A high-throughput single-cell analysis of human CD8⺠T cell functions reveals discordance for cytokine secretion and cytolysis. The Journal of Clinical Investigation. 121: 4322-31. PMID 21965332 DOI: 10.1172/Jci58653 |
0.401 |
|
| 2009 |
Varadarajan N, Pogson M, Georgiou G, Iverson BL. Proteases that can distinguish among different post-translational forms of tyrosine engineered using multicolor flow cytometry. Journal of the American Chemical Society. 131: 18186-90. PMID 19924991 DOI: 10.1021/Ja907803K |
0.614 |
|
| 2009 |
Varadarajan N, Cantor JR, Georgiou G, Iverson BL. Construction and flow cytometric screening of targeted enzyme libraries. Nature Protocols. 4: 893-901. PMID 19478805 DOI: 10.1038/Nprot.2009.60 |
0.611 |
|
| 2008 |
Varadarajan N, Georgiou G, Iverson BL. An engineered protease that cleaves specifically after sulfated tyrosine. Angewandte Chemie (International Ed. in English). 47: 7861-3. PMID 18780393 DOI: 10.1002/Anie.200800736 |
0.635 |
|
| 2008 |
Varadarajan N, Rodriguez S, Hwang BY, Georgiou G, Iverson BL. Highly active and selective endopeptidases with programmed substrate specificities. Nature Chemical Biology. 4: 290-4. PMID 18391948 DOI: 10.1038/Nchembio.80 |
0.585 |
|
| 2007 |
Hwang BY, Varadarajan N, Li H, Rodriguez S, Iverson BL, Georgiou G. Substrate specificity of the Escherichia coli outer membrane protease OmpP. Journal of Bacteriology. 189: 522-30. PMID 17085556 DOI: 10.1128/JB.01493-06 |
0.552 |
|
| 2005 |
Varadarajan N, Gam J, Olsen MJ, Georgiou G, Iverson BL. Engineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity. Proceedings of the National Academy of Sciences of the United States of America. 102: 6855-60. PMID 15867160 DOI: 10.1073/Pnas.0500063102 |
0.663 |
|
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