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Patrick J. Lupardus, Ph.D. - Publications

Affiliations: 
2005 Stanford University, Palo Alto, CA 
Area:
DNA damage response
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23 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Rajapaksa NS, Gobbi A, Drobnick J, Do S, Kolesnikov A, Liang J, Chen Y, Sujatha-Bhaskar S, Huang Z, Brightbill H, Francis R, Yu C, Choo EF, DeMent K, Ran Y, ... ... Lupardus PJ, et al. Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity. Acs Medicinal Chemistry Letters. 11: 327-333. PMID 32184965 DOI: 10.1021/Acsmedchemlett.9B00380  0.302
2019 Hamilton GL, Chen H, Deshmukh G, Eigenbrot C, Fong R, Johnson A, Kohli PB, Lupardus PJ, Liederer BM, Ramaswamy S, Wang H, Wang J, Xu Z, Zhu Y, Vucic D, et al. Potent and selective inhibitors of receptor-interacting protein kinase 1 that lack an aromatic back pocket group. Bioorganic & Medicinal Chemistry Letters. PMID 31000154 DOI: 10.1016/J.Bmcl.2019.04.014  0.341
2019 Patel S, Webster JD, Varfolomeev E, Kwon YC, Cheng JH, Zhang J, Dugger DL, Wickliffe KE, Maltzman A, Sujatha-Bhaskar S, Kohli PB, Ramaswamy S, Deshmukh G, Liederer BM, Fong R, ... ... Lupardus P, et al. RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases. Cell Death & Differentiation. 27: 161-175. DOI: 10.2210/Pdb6Nyh/Pdb  0.303
2018 Ferrao RD, Wallweber HJ, Lupardus PJ. Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation. Elife. 7. PMID 30044226 DOI: 10.7554/Elife.38089  0.359
2018 Ferrao RD, Wallweber HJ, Lupardus PJ. Author response: Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation Elife. DOI: 10.7554/Elife.38089.022  0.31
2017 Ferrao R, Lupardus PJ. The Janus Kinase (JAK) FERM and SH2 Domains: Bringing Specificity to JAK-Receptor Interactions. Frontiers in Endocrinology. 8: 71. PMID 28458652 DOI: 10.3389/Fendo.2017.00071  0.344
2016 Ferrao R, Wallweber HJ, Ho H, Tam C, Franke Y, Quinn J, Lupardus PJ. The Structural Basis for Class II Cytokine Receptor Recognition by JAK1. Structure (London, England : 1993). PMID 27133025 DOI: 10.1016/J.Str.2016.03.023  0.312
2014 Lupardus PJ, Ultsch M, Wallweber H, Bir Kohli P, Johnson AR, Eigenbrot C. Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition. Proceedings of the National Academy of Sciences of the United States of America. 111: 8025-30. PMID 24843152 DOI: 10.1073/Pnas.1401180111  0.354
2014 Wallweber HJ, Tam C, Franke Y, Starovasnik MA, Lupardus PJ. Structural basis of recognition of interferon-α receptor by tyrosine kinase 2. Nature Structural & Molecular Biology. 21: 443-8. PMID 24704786 DOI: 10.1038/Nsmb.2807  0.332
2014 Wallweber HJA, Tam C, Franke Y, Starovasnik MA, Lupardus PJ. Structural basis of IFN receptor recognition by TYK2 Nature Structural & Molecular Biology. 21: 443. DOI: 10.2210/Pdb4Po6/Pdb  0.336
2011 Shen A, Lupardus PJ, Gersch MM, Puri AW, Albrow VE, Garcia KC, Bogyo M. Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins. Nature Structural & Molecular Biology. 18: 364-71. PMID 21317893 DOI: 10.1038/Nsmb.1990  0.328
2010 Puri AW, Lupardus PJ, Deu E, Albrow VE, Garcia KC, Bogyo M, Shen A. Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB. Chemistry & Biology. 17: 1201-11. PMID 21095570 DOI: 10.1016/J.Chembiol.2010.09.011  0.311
2009 Shen A, Lupardus PJ, Albrow VE, Guzzetta A, Powers JC, Garcia KC, Bogyo M. Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin. Nature Chemical Biology. 5: 469-78. PMID 19465933 DOI: 10.1038/Nchembio.178  0.317
2008 Lupardus PJ, Shen A, Bogyo M, Garcia KC. Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain. Science (New York, N.Y.). 322: 265-8. PMID 18845756 DOI: 10.1126/Science.1162403  0.321
2007 Lupardus PJ, Van C, Cimprich KA. Analyzing the ATR-mediated checkpoint using Xenopus egg extracts. Methods (San Diego, Calif.). 41: 222-31. PMID 17189864 DOI: 10.1016/J.Ymeth.2006.07.024  0.69
2006 Chang DJ, Lupardus PJ, Cimprich KA. Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires uncoupling of DNA polymerase and mini-chromosome maintenance helicase activities. The Journal of Biological Chemistry. 281: 32081-8. PMID 16959771 DOI: 10.1074/Jbc.M606799200  0.752
2006 Bomgarden RD, Lupardus PJ, Soni DV, Yee MC, Ford JM, Cimprich KA. Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling. The Embo Journal. 25: 2605-14. PMID 16675950 DOI: 10.1038/Sj.Emboj.7601123  0.721
2006 Lupardus PJ, Cimprich KA. Phosphorylation of Xenopus Rad1 and Hus1 defines a readout for ATR activation that is independent of Claspin and the Rad9 carboxy terminus. Molecular Biology of the Cell. 17: 1559-69. PMID 16436514 DOI: 10.1091/Mbc.E05-09-0865  0.701
2006 Sobeck A, Stone S, Costanzo V, de Graaf B, Reuter T, de Winter J, Wallisch M, Akkari Y, Olson S, Wang W, Joenje H, Christian JL, Lupardus PJ, Cimprich KA, Gautier J, et al. Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks. Molecular and Cellular Biology. 26: 425-37. PMID 16382135 DOI: 10.1128/Mcb.26.2.425-437.2006  0.715
2004 Lupardus PJ, Cimprich KA. Checkpoint adaptation; molecular mechanisms uncovered. Cell. 117: 555-6. PMID 15163402 DOI: 10.1016/J.Cell.2004.05.005  0.654
2003 Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J. An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Molecular Cell. 11: 203-13. PMID 12535533 DOI: 10.1016/S1097-2765(02)00799-2  0.723
2002 Lupardus PJ, Byun T, Yee MC, Hekmat-Nejad M, Cimprich KA. A requirement for replication in activation of the ATR-dependent DNA damage checkpoint. Genes & Development. 16: 2327-32. PMID 12231621 DOI: 10.1101/Gad.1013502  0.752
1999 Wilke RA, Mehta RP, Lupardus PJ, Chen Y, Ruoho AE, Jackson MB. Sigma receptor photolabeling and sigma receptor-mediated modulation of potassium channels in tumor cells. The Journal of Biological Chemistry. 274: 18387-92. PMID 10373444 DOI: 10.1074/Jbc.274.26.18387  0.318
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