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Morgan A. Huse, Ph.D. - Publications

Affiliations: 
2001 Rockefeller University, New York, NY, United States 
Area:
Structural Biology of Cellular Signal Transduction and DNA Replication
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Sanchez EE, Tello-Lafoz M, Guo AJ, de Jesus M, Elbanna YA, Winer BY, Budhu S, Chan E, Rosiek E, Kondo T, DuSold J, Taylor N, Altan-Bonnet G, Olson MF, Huse M. Apoptotic contraction drives target cell release by cytotoxic T cells. Nature Immunology. PMID 37500886 DOI: 10.1038/s41590-023-01572-4  0.6
2023 de Jesus M, Settle AH, Vorselen D, Gaetjens TK, Galiano M, Wong YY, Fu TM, Santosa E, Winer BY, Tamzalit F, Wang MS, Bao Z, Sun JC, Shah P, Theriot JA, ... ... Huse M, et al. Topographical analysis of immune cell interactions reveals a biomechanical signature for immune cytolysis. Biorxiv : the Preprint Server For Biology. PMID 37131635 DOI: 10.1101/2023.04.16.537078  0.306
2022 Mansilla-Soto J, Eyquem J, Haubner S, Hamieh M, Feucht J, Paillon N, Zucchetti AE, Li Z, Sjöstrand M, Lindenbergh PL, Saetersmoen M, Dobrin A, Maurin M, Iyer A, Garcia Angus A, ... ... Huse M, et al. HLA-independent T cell receptors for targeting tumors with low antigen density. Nature Medicine. PMID 35027758 DOI: 10.1038/s41591-021-01621-1  0.32
2020 Chaudhuri PK, Wang MS, Black CT, Huse M, Kam LC. Modulating T Cell Activation Using Depth Sensing Topographic Cues. Advanced Biosystems. e2000143. PMID 32744809 DOI: 10.1002/adbi.202000143  0.371
2020 Tamzalit F, Tran D, Jin W, Boyko V, Bazzi H, Kepecs A, Kam LC, Anderson KV, Huse M. Centrioles control the capacity, but not the specificity, of cytotoxic T cell killing. Proceedings of the National Academy of Sciences of the United States of America. PMID 32041868 DOI: 10.1073/pnas.1913220117  0.308
2019 Jin W, Tamzalit F, Chaudhuri PK, Black CT, Huse M, Kam LC. T cell activation and immune synapse organization respond to the microscale mechanics of structured surfaces. Proceedings of the National Academy of Sciences of the United States of America. PMID 31527238 DOI: 10.1073/Pnas.1906986116  0.342
2019 Sanchez E, Liu X, Huse M. Actin clearance promotes polarized dynein accumulation at the immunological synapse. Plos One. 14: e0210377. PMID 31269031 DOI: 10.1371/journal.pone.0210377  0.348
2019 Hamieh M, Dobrin A, Cabriolu A, van der Stegen SJC, Giavridis T, Mansilla-Soto J, Eyquem J, Zhao Z, Whitlock BM, Miele MM, Li Z, Cunanan KM, Huse M, Hendrickson RC, Wang X, et al. CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape. Nature. PMID 30918399 DOI: 10.1038/S41586-019-1054-1  0.349
2019 Tamzalit F, Wang MS, Jin W, Tello-Lafoz M, Boyko V, Heddleston JM, Black CT, Kam LC, Huse M. Interfacial actin protrusions mechanically enhance killing by cytotoxic T cells. Science Immunology. 4. PMID 30902904 DOI: 10.1126/Sciimmunol.Aav5445  0.323
2018 Sanchez E, Huse M. Spatial and Temporal Control of T Cell Activation Using a Photoactivatable Agonist. Journal of Visualized Experiments : Jove. PMID 29757266 DOI: 10.3791/56655  0.363
2017 Tello-Lafoz M, Martínez-Martínez G, Rodríguez-Rodríguez C, Albar JP, Huse M, Gharbi S, Merida I. Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse. Traffic (Copenhagen, Denmark). 18: 491-504. PMID 28477369 DOI: 10.1111/tra.12492  0.357
2017 Oyler-Yaniv A, Oyler-Yaniv J, Whitlock BM, Liu Z, Germain RN, Huse M, Altan-Bonnet G, Krichevsky O. A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System. Immunity. PMID 28389069 DOI: 10.1016/J.Immuni.2017.03.011  0.557
2017 Le Floc'h A, Tanaka Y, Bantilan NS, Voisinne G, Altan-Bonnet G, Fukui Y, Huse M. Correction: Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse. The Journal of Experimental Medicine. PMID 28292823 DOI: 10.1084/Jem.2013132403102017C  0.541
2016 Dadi S, Chhangawala S, Whitlock BM, Franklin RA, Luo CT, Oh SA, Toure A, Pritykin Y, Huse M, Leslie CS, Li MO. Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells. Cell. PMID 26806130 DOI: 10.1016/J.Cell.2016.01.002  0.305
2014 Le Floc'h A, Huse M. Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse. Cellular and Molecular Life Sciences : Cmls. 72: 537-556. PMID 25355055 DOI: 10.1007/s00018-014-1760-7  0.346
2014 Chauveau A, Le Floc'h A, Bantilan NS, Koretzky GA, Huse M. Diacylglycerol kinase α establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse. Science Signaling. 7: ra82. PMID 25161317 DOI: 10.1126/Scisignal.2005287  0.354
2014 Huse M, Le Floc'h A, Liu X. From lipid second messengers to molecular motors: microtubule-organizing center reorientation in T cells. Immunological Reviews. 256: 95-106. PMID 24117815 DOI: 10.1111/imr.12116  0.33
2013 Le Floc'h A, Tanaka Y, Bantilan NS, Voisinne G, Altan-Bonnet G, Fukui Y, Huse M. Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse. The Journal of Experimental Medicine. 210: 2721-37. PMID 24190432 DOI: 10.1085/Jgp.1426Oia47  0.623
2013 Liu X, Kapoor TM, Chen JK, Huse M. Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II. Proceedings of the National Academy of Sciences of the United States of America. 110: 11976-81. PMID 23818610 DOI: 10.1073/Pnas.1306180110  0.371
2013 Gasteiger G, Hemmers S, Firth MA, Le Floc'h A, Huse M, Sun JC, Rudensky AY. IL-2-dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells. The Journal of Experimental Medicine. 210: 1167-78. PMID 23650441 DOI: 10.1084/Jem.20122462  0.312
2012 Ouyang W, Liao W, Luo CT, Yin N, Huse M, Kim MV, Peng M, Chan P, Ma Q, Mo Y, Meijer D, Zhao K, Rudensky AY, Atwal G, Zhang MQ, et al. Novel Foxo1-dependent transcriptional programs control T(reg) cell function. Nature. 491: 554-9. PMID 23135404 DOI: 10.1038/Nature11581  0.352
2012 Merino E, Abeyweera TP, Firth MA, Zawislak CL, Basu R, Liu X, Sun JC, Huse M. Protein kinase C-θ clustering at immunological synapses amplifies effector responses in NK cells. Journal of Immunology (Baltimore, Md. : 1950). 189: 4859-69. PMID 23077238 DOI: 10.4049/jimmunol.1200825  0.329
2012 Huse M. Microtubule-organizing center polarity and the immunological synapse: protein kinase C and beyond. Frontiers in Immunology. 3: 235. PMID 23060874 DOI: 10.3389/fimmu.2012.00235  0.38
2011 Huse M. Lymphocyte polarity, the immunological synapse and the scope of biological analogy. Bioarchitecture. 1: 180-185. PMID 22069511 DOI: 10.4161/bioa.1.4.17594  0.326
2011 Quann EJ, Liu X, Altan-Bonnet G, Huse M. A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells. Nature Immunology. 12: 647-54. PMID 21602810 DOI: 10.1038/Ni.2033  0.641
2010 Huse M. Photochemical approaches to T-cell activation. Immunology. 130: 151-7. PMID 20406301 DOI: 10.1111/j.1365-2567.2010.03267.x  0.34
2010 Kuhns MS, Girvin AT, Klein LO, Chen R, Jensen KD, Newell EW, Huppa JB, Lillemeier BF, Huse M, Chien YH, Garcia KC, Davis MM. Evidence for a functional sidedness to the alphabetaTCR. Proceedings of the National Academy of Sciences of the United States of America. 107: 5094-9. PMID 20202921 DOI: 10.1073/Pnas.1000925107  0.516
2009 Quann EJ, Merino E, Furuta T, Huse M. Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells. Nature Immunology. 10: 627-35. PMID 19430478 DOI: 10.1038/ni.1734  0.323
2008 Huse M, Quann EJ, Davis MM. Shouts, whispers and the kiss of death: directional secretion in T cells. Nature Immunology. 9: 1105-11. PMID 18800163 DOI: 10.1038/Ni.F.215  0.515
2007 Huse M, Klein LO, Girvin AT, Faraj JM, Li QJ, Kuhns MS, Davis MM. Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist. Immunity. 27: 76-88. PMID 17629516 DOI: 10.1016/J.Immuni.2007.05.017  0.551
2007 Davis MM, Krogsgaard M, Huse M, Huppa J, Lillemeier BF, Li QJ. T cells as a self-referential, sensory organ. Annual Review of Immunology. 25: 681-95. PMID 17291190 DOI: 10.1146/Annurev.Immunol.24.021605.090600  0.486
2006 Huse M, Lillemeier BF, Kuhns MS, Chen DS, Davis MM. T cells use two directionally distinct pathways for cytokine secretion. Nature Immunology. 7: 247-55. PMID 16444260 DOI: 10.1038/Ni1304  0.594
2005 Krogsgaard M, Li QJ, Sumen C, Huppa JB, Huse M, Davis MM. Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. Nature. 434: 238-43. PMID 15724150 DOI: 10.1038/Nature03391  0.672
2004 Ottesen JJ, Huse M, Sekedat MD, Muir TW. Semisynthesis of phosphovariants of Smad2 reveals a substrate preference of the activated T beta RI kinase. Biochemistry. 43: 5698-706. PMID 15134444 DOI: 10.1021/Bi0498407  0.384
2002 Huse M, Kuriyan J. The conformational plasticity of protein kinases. Cell. 109: 275-82. PMID 12015977 DOI: 10.1016/S0092-8674(02)00741-9  0.559
2002 Flavell RR, Huse M, Goger M, Trester-Zedlitz M, Kuriyan J, Muir TW. Efficient semisynthesis of a tetraphosphorylated analogue of the Type I TGFbeta receptor. Organic Letters. 4: 165-8. PMID 11796041 DOI: 10.1021/Ol016859I  0.528
2001 Wu JW, Hu M, Chai J, Seoane J, Huse M, Li C, Rigotti DJ, Kyin S, Muir TW, Fairman R, Massagué J, Shi Y. Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling. Molecular Cell. 8: 1277-89. PMID 11779503 DOI: 10.1016/S1097-2765(01)00421-X  0.396
2001 Huse M, Muir TW, Xu L, Chen YG, Kuriyan J, Massagué J. The TGF beta receptor activation process: an inhibitor- to substrate-binding switch. Molecular Cell. 8: 671-82. PMID 11583628 DOI: 10.1016/S1097-2765(01)00332-X  0.549
2000 Huse M, Holford MN, Kuriyan J, Muir TW. Semisynthesis of hyperphosphorylated type I TGFβ receptor: Addressing the mechanism of kinase activation [20] Journal of the American Chemical Society. 122: 8337-8338. DOI: 10.1021/Ja001763P  0.543
1999 Huse M, Chen YG, Massagué J, Kuriyan J. Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12. Cell. 96: 425-36. PMID 10025408 DOI: 10.1016/S0092-8674(00)80555-3  0.565
1997 Moarefi I, LaFevre-Bernt M, Sicheri F, Huse M, Lee CH, Kuriyan J, Miller WT. Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement Nature. 385: 650-653. PMID 9024665 DOI: 10.1038/385650A0  0.637
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