Year |
Citation |
Score |
2019 |
Kelleher JF, Campbell V, Chen J, Gollob J, Ji N, Kamadurai H, Klaus C, Li H, Loh C, McDonald A, Rong H, Rusin S, Sharma K, Vigil D, Walker D, et al. Abstract LB-272: KYM-001, a first-in-class oral IRAK4 protein degrader, induces tumor regression in xenograft models of MYD88-mutant ABC DLBCL alone and in combination with BTK inhibition Cancer Research. 79. DOI: 10.1158/1538-7445.Am2019-Lb-272 |
0.33 |
|
2013 |
Vigil D, Der CJ. Inhibitors of the ROCK serine/threonine kinases: key effectors of the RhoA small GTPase. The Enzymes. 33: 193-212. PMID 25033806 DOI: 10.1016/B978-0-12-416749-0.00009-9 |
0.342 |
|
2010 |
Vigil D, Cherfils J, Rossman KL, Der CJ. Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nature Reviews. Cancer. 10: 842-57. PMID 21102635 DOI: 10.1038/Nrc2960 |
0.309 |
|
2006 |
Rho BS, Hung LW, Holton JM, Vigil D, Kim SI, Park MS, Terwilliger TC, Pédelacq JD. Functional and structural characterization of a thiol peroxidase from Mycobacterium tuberculosis. Journal of Molecular Biology. 361: 850-63. PMID 16884737 DOI: 10.1016/J.Jmb.2006.05.076 |
0.307 |
|
2006 |
Kim C, Vigil D, Anand G, Taylor SS. Structure and dynamics of PKA signaling proteins. European Journal of Cell Biology. 85: 651-4. PMID 16647784 DOI: 10.1016/J.Ejcb.2006.02.004 |
0.403 |
|
2006 |
Vigil D, Blumenthal DK, Taylor SS, Trewhella J. Solution scattering reveals large differences in the global structures of type II protein kinase A isoforms. Journal of Molecular Biology. 357: 880-9. PMID 16460759 DOI: 10.1016/J.Jmb.2006.01.006 |
0.587 |
|
2006 |
Vigil D, Lin JH, Sotriffer CA, Pennypacker JK, McCammon JA, Taylor SS. A simple electrostatic switch important in the activation of type I protein kinase A by cyclic AMP. Protein Science : a Publication of the Protein Society. 15: 113-21. PMID 16322564 DOI: 10.1110/Ps.051723606 |
0.588 |
|
2005 |
Taylor SS, Kim C, Vigil D, Haste NM, Yang J, Wu J, Anand GS. Dynamics of signaling by PKA. Biochimica Et Biophysica Acta. 1754: 25-37. PMID 16214430 DOI: 10.1016/J.Bbapap.2005.08.024 |
0.584 |
|
2005 |
Vigil D, Blumenthal DK, Taylor SS, Trewhella J. The conformationally dynamic C helix of the RIalpha subunit of protein kinase A mediates isoform-specific domain reorganization upon C subunit binding. The Journal of Biological Chemistry. 280: 35521-7. PMID 16109722 DOI: 10.1074/Jbc.M506769200 |
0.579 |
|
2004 |
Vigil D, Blumenthal DK, Brown S, Taylor SS, Trewhella J. Differential effects of substrate on type I and type II PKA holoenzyme dissociation. Biochemistry. 43: 5629-36. PMID 15134437 DOI: 10.1021/Bi0499157 |
0.512 |
|
2004 |
Vigil D, Blumenthal DK, Heller WT, Brown S, Canaves JM, Taylor SS, Trewhella J. Conformational differences among solution structures of the type Ialpha, IIalpha and IIbeta protein kinase A regulatory subunit homodimers: role of the linker regions. Journal of Molecular Biology. 337: 1183-94. PMID 15046986 DOI: 10.1016/J.Jmb.2004.02.028 |
0.59 |
|
2004 |
Heller WT, Vigil D, Brown S, Blumenthal DK, Taylor SS, Trewhella J. C subunits binding to the protein kinase A RI alpha dimer induce a large conformational change. The Journal of Biological Chemistry. 279: 19084-90. PMID 14985329 DOI: 10.1074/Jbc.M313405200 |
0.528 |
|
2001 |
Vigil D, Gallagher SC, Trewhella J, GarcÃa AE. Functional dynamics of the hydrophobic cleft in the N-domain of calmodulin. Biophysical Journal. 80: 2082-92. PMID 11325712 DOI: 10.1016/S0006-3495(01)76182-6 |
0.392 |
|
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