| Year |
Citation |
Score |
| 2024 |
Barylko B, Taylor CA, Wang J, Earnest S, Stippec S, Binns DD, Brautigam CA, Jameson DM, DeMartino GN, Cobb MH, Albanesi JP. Mimicking Protein Kinase C Phosphorylation Inhibits Arc/Arg3.1 Palmitoylation and Its Interaction with Nucleic Acids. International Journal of Molecular Sciences. 25. PMID 38255853 DOI: 10.3390/ijms25020780 |
0.332 |
|
| 2023 |
Martin-Vega A, Cobb MH. Navigating the ERK1/2 MAPK Cascade. Biomolecules. 13. PMID 37892237 DOI: 10.3390/biom13101555 |
0.438 |
|
| 2023 |
Jung JU, Cobb MH. WNK1 controls endosomal trafficking through TRIM27-dependent regulation of actin assembly. Proceedings of the National Academy of Sciences of the United States of America. 120: e2300310120. PMID 37307465 DOI: 10.1073/pnas.2300310120 |
0.373 |
|
| 2023 |
Kalwat MA, Rodrigues-Dos-Santos K, Binns DD, Wei S, Zhou A, Evans MR, Posner BA, Roth MG, Cobb MH. Small molecule glucagon release inhibitors with activity in human islets. Frontiers in Endocrinology. 14: 1114799. PMID 37152965 DOI: 10.3389/fendo.2023.1114799 |
0.723 |
|
| 2022 |
Jaykumar AB, Plumber S, Barry DM, Binns D, Wichaidit C, Grzemska M, Earnest S, Goldsmith EJ, Cleaver O, Cobb MH. WNK1 collaborates with TGF-β in endothelial cell junction turnover and angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 119: e2203743119. PMID 35867836 DOI: 10.1073/pnas.2203743119 |
0.798 |
|
| 2022 |
Rodrigues-Dos-Santos K, Roy G, Binns DD, Grzemska MG, Barella LF, Armoo F, McCoy MK, Huynh AV, Yang JZ, Posner BA, Cobb MH, Kalwat MA. Small molecule-mediated insulin hypersecretion induces transient ER stress response and loss of beta cell function. Endocrinology. PMID 35641126 DOI: 10.1210/endocr/bqac081 |
0.769 |
|
| 2021 |
Wang XD, Kim C, Zhang Y, Rindhe S, Cobb MH, Yu Y. Cholesterol Regulates the Tumor Adaptive Resistance to MAPK Pathway Inhibition. Journal of Proteome Research. PMID 34751028 DOI: 10.1021/acs.jproteome.1c00550 |
0.325 |
|
| 2021 |
Kalwat MA, Scheuner D, Rodrigues Dos Santos K, Eizirik DL, Cobb MH. The pancreatic β cell response to secretory demands and adaption to stress. Endocrinology. PMID 34407177 DOI: 10.1210/endocr/bqab173 |
0.744 |
|
| 2021 |
Jaykumar AB, Jung JU, Parida PK, Dang TT, Wichaidit C, Kannangara AR, Earnest S, Goldsmith EJ, Pearson GW, Malladi S, Cobb MH. WNK1 Enhances Migration and Invasion in Breast Cancer Models. Molecular Cancer Therapeutics. PMID 34253593 DOI: 10.1158/1535-7163.MCT-21-0174 |
0.688 |
|
| 2020 |
Liu Z, Yoon J, Wichaidit C, Jaykumar AB, Dbouk HA, Embry AE, Liu L, Henderson JM, Chang AN, Cobb MH, Miller RT. Control of Podocyte and Glomerular Capillary Wall Structure and Elasticity by WNK1 Kinase. Frontiers in Cell and Developmental Biology. 8: 618898. PMID 33604334 DOI: 10.3389/fcell.2020.618898 |
0.309 |
|
| 2020 |
Kalwat MA, Huang Z, Binns DD, McGlynn K, Cobb MH. α-Adrenergic Disruption of β Cell BDNF-TrkB Receptor Tyrosine Kinase Signaling. Frontiers in Cell and Developmental Biology. 8: 576396. PMID 33178692 DOI: 10.3389/fcell.2020.576396 |
0.794 |
|
| 2019 |
Shen C, Li B, Astudillo L, Deutscher MP, Cobb MH, Capobianco AJ, Lee E, Robbins DJ. The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (/) of CK1α. Biochemistry. PMID 31820934 DOI: 10.1021/Acs.Biochem.9B00891 |
0.625 |
|
| 2019 |
Kalwat M, Cobb MH. Measuring Relative Insulin Secretion using a Co-Secreted Luciferase Surrogate. Journal of Visualized Experiments : Jove. PMID 31305532 DOI: 10.3791/59926 |
0.71 |
|
| 2018 |
Gallolu Kankanamalage S, Karra AS, Cobb MH. WNK pathways in cancer signaling networks. Cell Communication and Signaling : Ccs. 16: 72. PMID 30390653 DOI: 10.1186/s12964-018-0287-1 |
0.814 |
|
| 2018 |
Kalwat MA, Hwang IH, Macho J, Grzemska MG, Yang JZ, McGlynn K, MacMillan JB, Cobb MH. Chromomycin A potently inhibits glucose-stimulated insulin secretion from pancreatic β cells. The Journal of General Physiology. PMID 30352794 DOI: 10.1085/Jgp.201812177 |
0.788 |
|
| 2018 |
Jaykumar AB, Karra AS, Cobb MH. Pulling a MAST1 on Cisplatin Resistance. Cancer Cell. 34: 183-185. PMID 30107173 DOI: 10.1016/j.ccell.2018.07.010 |
0.799 |
|
| 2018 |
Thorne CA, Chen IW, Sanman LE, Cobb MH, Wu LF, Altschuler SJ. Enteroid Monolayers Reveal an Autonomous WNT and BMP Circuit Controlling Intestinal Epithelial Growth and Organization. Developmental Cell. PMID 29503158 DOI: 10.1016/J.Devcel.2018.01.024 |
0.666 |
|
| 2017 |
Kalwat MA, Wichaidit C, Nava Garcia AY, McCoy MK, McGlynn K, Hwang IH, MacMillan JB, Posner BA, Cobb MH. Correction to Insulin Promoter-Driven Gaussia Luciferase-Based Insulin Secretion Biosensor Assay for Discovery of β-Cell Glucose-Sensing Pathways. Acs Sensors. 2: 316. PMID 28723136 DOI: 10.1021/acssensors.7b00012 |
0.731 |
|
| 2017 |
Li B, Orton D, Neitzel LR, Astudillo L, Shen C, Long J, Chen X, Kirkbride KC, Doundoulakis T, Guerra ML, Zaias J, Fei DL, Rodriguez-Blanco J, Thorne C, Wang Z, ... ... Cobb MH, et al. Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors. Science Signaling. 10. PMID 28655862 DOI: 10.1126/Scisignal.Aak9916 |
0.794 |
|
| 2017 |
Karra AS, Stippec S, Cobb MH. Assaying Protein Kinase Activity with Radiolabeled ATP. Journal of Visualized Experiments : Jove. PMID 28605363 DOI: 10.3791/55504 |
0.821 |
|
| 2017 |
Kalwat MA, Cobb M. Mechanisms of the Amplifying Pathway of Insulin Secretion in the β Cell. Pharmacology & Therapeutics. PMID 28527919 DOI: 10.1016/j.pharmthera.2017.05.003 |
0.741 |
|
| 2017 |
Gallolu Kankanamalage S, Lee AY, Wichaidit C, Lorente-Rodriguez A, Shah AM, Stippec S, Whitehurst AW, Cobb MH. WNK1 is an unexpected autophagy inhibitor. Autophagy. 1-2. PMID 28282258 DOI: 10.1080/15548627.2017.1286431 |
0.751 |
|
| 2017 |
Guerra ML, Kalwat MA, McGlynn K, Cobb MH. Sucralose activates an ERK1/2-ribosomal protein S6 signaling axis. Febs Open Bio. 7: 174-186. PMID 28174684 DOI: 10.1002/2211-5463.12172 |
0.835 |
|
| 2016 |
Gallolu Kankanamalage S, Lee AY, Wichaidit C, Lorente-Rodriguez A, Shah AM, Stippec S, Whitehurst AW, Cobb MH. Multistep regulation of autophagy by WNK1. Proceedings of the National Academy of Sciences of the United States of America. PMID 27911840 DOI: 10.1073/pnas.1617649113 |
0.765 |
|
| 2016 |
Kalwat MA, Wichaidit C, Nava Garcia AY, McCoy MK, McGlynn K, Hwang IH, MacMillan JB, Posner BA, Cobb MH. Insulin promoter-driven Gaussia luciferase-based insulin secretion biosensor assay for discovery of β-cell glucose-sensing pathways. Acs Sensors. 1: 1208-1212. PMID 27819058 DOI: 10.1021/Acssensors.6B00433 |
0.732 |
|
| 2016 |
McReynolds AC, Karra AS, Li Y, Lopez ED, Turjanski AG, Dioum E, Lorenz K, Zaganjor E, Stippec S, McGlynn K, Earnest S, Cobb MH. Phosphorylation or mutation of the ERK2 activation loop alters oligonucleotide binding. Biochemistry. PMID 26950759 DOI: 10.1021/Acs.Biochem.6B00096 |
0.812 |
|
| 2016 |
Kalwat MA, Huang Z, Wichaidit C, McGlynn K, Earnest S, Savoia C, Dioum EM, Schneider JW, Hutchison MR, Cobb MH. Isoxazole alters metabolites and gene expression, decreasing proliferation and promoting a neuroendocrine phenotype in β-cells. Acs Chemical Biology. PMID 26828310 DOI: 10.1021/acschembio.5b00993 |
0.737 |
|
| 2015 |
Karra AS, Taylor CA, Thorne CA, Cobb MH. A Kinase Divided. Cancer Cell. 28: 145-7. PMID 26267529 DOI: 10.1016/J.Ccell.2015.07.008 |
0.819 |
|
| 2015 |
Taylor CA, Juang YC, Earnest S, Sengupta S, Goldsmith EJ, Cobb MH. Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK. Biochemistry. PMID 26208601 DOI: 10.1021/Acs.Biochem.5B00593 |
0.302 |
|
| 2015 |
Wauson EM, Guerra ML, Dyachok J, McGlynn K, Giles J, Ross EM, Cobb MH. Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells. Molecular Endocrinology (Baltimore, Md.). 29: 1114-22. PMID 26168033 DOI: 10.1210/Me.2014-1181 |
0.828 |
|
| 2014 |
Dbouk HA, Weil LM, Perera GK, Dellinger MT, Pearson G, Brekken RA, Cobb MH. Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK. Proceedings of the National Academy of Sciences of the United States of America. 111: 15999-6004. PMID 25362046 DOI: 10.1073/Pnas.1419057111 |
0.747 |
|
| 2014 |
Klein AM, Cobb MH. ERK5 signaling gets XIAPed: a role for ubiquitin in the disassembly of a MAPK cascade. The Embo Journal. 33: 1735-6. PMID 25012518 DOI: 10.15252/embj.201489205 |
0.569 |
|
| 2014 |
Zaganjor E, Weil LM, Gonzales JX, Minna JD, Cobb MH. Ras transformation uncouples the kinesin-coordinated cellular nutrient response. Proceedings of the National Academy of Sciences of the United States of America. 111: 10568-73. PMID 25002494 DOI: 10.1073/Pnas.1411016111 |
0.726 |
|
| 2014 |
Piala AT, Moon TM, Akella R, He H, Cobb MH, Goldsmith EJ. Chloride sensing by WNK1 involves inhibition of autophosphorylation. Science Signaling. 7: ra41. PMID 24803536 DOI: 10.1126/Scisignal.2005050 |
0.311 |
|
| 2014 |
Wauson EM, Dbouk HA, Ghosh AB, Cobb MH. G protein-coupled receptors and the regulation of autophagy. Trends in Endocrinology and Metabolism: Tem. 25: 274-82. PMID 24751357 DOI: 10.1016/J.Tem.2014.03.006 |
0.741 |
|
| 2014 |
Osborne JK, Guerra ML, Gonzales JX, McMillan EA, Minna JD, Cobb MH. NeuroD1 mediates nicotine-induced migration and invasion via regulation of the nicotinic acetylcholine receptor subunits in a subset of neural and neuroendocrine carcinomas. Molecular Biology of the Cell. 25: 1782-92. PMID 24719457 DOI: 10.1091/Mbc.E13-06-0316 |
0.633 |
|
| 2014 |
Guerra ML, Wauson EM, McGlynn K, Cobb MH. Muscarinic control of MIN6 pancreatic β cells is enhanced by impaired amino acid signaling. The Journal of Biological Chemistry. 289: 14370-9. PMID 24695728 DOI: 10.1074/Jbc.M114.565069 |
0.801 |
|
| 2014 |
Zaganjor E, Osborne JK, Weil LM, Diaz-Martinez LA, Gonzales JX, Singel SM, Larsen JE, Girard L, Minna JD, Cobb MH. Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells. Oncogene. 33: 5457-66. PMID 24240690 DOI: 10.1038/Onc.2013.486 |
0.706 |
|
| 2013 |
Sengupta S, Lorente-RodrÃguez A, Earnest S, Stippec S, Guo X, Trudgian DC, Mirzaei H, Cobb MH. Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals. Proceedings of the National Academy of Sciences of the United States of America. 110: 18826-31. PMID 24191005 DOI: 10.1073/Pnas.1318676110 |
0.437 |
|
| 2013 |
Wauson EM, Guerra ML, Barylko B, Albanesi JP, Cobb MH. Off-target effects of MEK inhibitors. Biochemistry. 52: 5164-6. PMID 23848362 DOI: 10.1021/Bi4007644 |
0.822 |
|
| 2013 |
Wauson EM, Lorente-RodrÃguez A, Cobb MH. Minireview: Nutrient sensing by G protein-coupled receptors. Molecular Endocrinology (Baltimore, Md.). 27: 1188-97. PMID 23820899 DOI: 10.1210/me.2013-1100 |
0.73 |
|
| 2013 |
Xu D, Cobb MG, Gavilano L, Witherspoon SM, Williams D, White CD, Taverna P, Bednarski BK, Kim HJ, Baldwin AS, Baines AT. Inhibition of oncogenic Pim-3 kinase modulates transformed growth and chemosensitizes pancreatic cancer cells to gemcitabine. Cancer Biology & Therapy. 14: 492-501. PMID 23760491 DOI: 10.4161/Cbt.24343 |
0.313 |
|
| 2013 |
Klein AM, Zaganjor E, Cobb MH. Chromatin-tethered MAPKs. Current Opinion in Cell Biology. 25: 272-7. PMID 23434067 DOI: 10.1016/J.Ceb.2013.01.002 |
0.811 |
|
| 2013 |
Wauson EM, Zaganjor E, Cobb MH. Amino acid regulation of autophagy through the GPCR TAS1R1-TAS1R3. Autophagy. 9: 418-9. PMID 23222068 DOI: 10.4161/Auto.22911 |
0.775 |
|
| 2012 |
Sengupta S, Tu SW, Wedin K, Earnest S, Stippec S, Luby-Phelps K, Cobb MH. Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activity. The Journal of Biological Chemistry. 287: 37868-79. PMID 22989884 DOI: 10.1074/jbc.M112.398750 |
0.313 |
|
| 2012 |
Wauson EM, Zaganjor E, Lee AY, Guerra ML, Ghosh AB, Bookout AL, Chambers CP, Jivan A, McGlynn K, Hutchison MR, Deberardinis RJ, Cobb MH. The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy. Molecular Cell. 47: 851-62. PMID 22959271 DOI: 10.1016/J.Molcel.2012.08.001 |
0.777 |
|
| 2012 |
Osborne JK, Zaganjor E, Cobb MH. Signal control through Raf: in sickness and in health. Cell Research. 22: 14-22. PMID 22143568 DOI: 10.1038/Cr.2011.193 |
0.774 |
|
| 2010 |
Klein AM, Dioum EM, Cobb MH. Exposing contingency plans for kinase networks. Cell. 143: 867-9. PMID 21145453 DOI: 10.1016/j.cell.2010.11.046 |
0.539 |
|
| 2010 |
Duan L, Cobb MH. Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback. Proceedings of the National Academy of Sciences of the United States of America. 107: 22314-9. PMID 21135229 DOI: 10.1073/pnas.1016630108 |
0.314 |
|
| 2010 |
Heise CJ, Xu BE, Deaton SL, Cha SK, Cheng CJ, Earnest S, Sengupta S, Juang YC, Stippec S, Xu Y, Zhao Y, Huang CL, Cobb MH. Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members. The Journal of Biological Chemistry. 285: 25161-7. PMID 20525693 DOI: 10.1074/Jbc.M110.103432 |
0.371 |
|
| 2009 |
Dioum EM, Wauson EM, Cobb MH. MAP-ping unconventional protein-DNA interactions. Cell. 139: 462-3. PMID 19879834 DOI: 10.1016/j.cell.2009.10.007 |
0.729 |
|
| 2009 |
Jivan A, Earnest S, Juang YC, Cobb MH. Radial spoke protein 3 is a mammalian protein kinase A-anchoring protein that binds ERK1/2. The Journal of Biological Chemistry. 284: 29437-45. PMID 19684019 DOI: 10.1074/jbc.M109.048181 |
0.363 |
|
| 2009 |
Zheng Y, Xia Y, Hawke D, Halle M, Tremblay ML, Gao X, Zhou XZ, Aldape K, Cobb MH, Xie K, He J, Lu Z. FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Molecular Cell. 35: 11-25. PMID 19595712 DOI: 10.1016/J.Molcel.2009.06.013 |
0.301 |
|
| 2009 |
Min X, Akella R, He H, Humphreys JM, Tsutakawa SE, Lee SJ, Tainer JA, Cobb MH, Goldsmith EJ. The structure of the MAP2K MEK6 reveals an autoinhibitory dimer. Structure (London, England : 1993). 17: 96-104. PMID 19141286 DOI: 10.1016/J.Str.2008.11.007 |
0.331 |
|
| 2009 |
Chen W, Chen Y, Xu BE, Juang YC, Stippec S, Zhao Y, Cobb MH. Regulation of a third conserved phosphorylation site in SGK1. The Journal of Biological Chemistry. 284: 3453-60. PMID 19068477 DOI: 10.1074/Jbc.M807502200 |
0.414 |
|
| 2008 |
Lawrence MC, McGlynn K, Shao C, Duan L, Naziruddin B, Levy MF, Cobb MH. Chromatin-bound mitogen-activated protein kinases transmit dynamic signals in transcription complexes in beta-cells. Proceedings of the National Academy of Sciences of the United States of America. 105: 13315-20. PMID 18755896 DOI: 10.1073/pnas.0806465105 |
0.343 |
|
| 2008 |
Lawrence MC, Jivan A, Shao C, Duan L, Goad D, Zaganjor E, Osborne J, McGlynn K, Stippec S, Earnest S, Chen W, Cobb MH. The roles of MAPKs in disease. Cell Research. 18: 436-42. PMID 18347614 DOI: 10.1038/Cr.2008.37 |
0.769 |
|
| 2008 |
Lawrence M, Shao C, Duan L, McGlynn K, Cobb MH. The protein kinases ERK1/2 and their roles in pancreatic beta cells. Acta Physiologica (Oxford, England). 192: 11-7. PMID 18171425 DOI: 10.1111/j.1748-1716.2007.01785.x |
0.365 |
|
| 2007 |
Huang CL, Cha SK, Wang HR, Xie J, Cobb MH. WNKs: protein kinases with a unique kinase domain. Experimental & Molecular Medicine. 39: 565-73. PMID 18059132 DOI: 10.1038/emm.2007.62 |
0.371 |
|
| 2007 |
Oh E, Heise CJ, English JM, Cobb MH, Thurmond DC. WNK1 is a novel regulator of Munc18c-syntaxin 4 complex formation in soluble NSF attachment protein receptor (SNARE)-mediated vesicle exocytosis. The Journal of Biological Chemistry. 282: 32613-22. PMID 17848561 DOI: 10.1074/jbc.M706591200 |
0.665 |
|
| 2007 |
Yazicioglu MN, Goad DL, Ranganathan A, Whitehurst AW, Goldsmith EJ, Cobb MH. Mutations in ERK2 binding sites affect nuclear entry. The Journal of Biological Chemistry. 282: 28759-67. PMID 17656361 DOI: 10.1074/Jbc.M703460200 |
0.701 |
|
| 2007 |
Raman M, Chen W, Cobb MH. Differential regulation and properties of MAPKs. Oncogene. 26: 3100-12. PMID 17496909 DOI: 10.1038/sj.onc.1210392 |
0.447 |
|
| 2007 |
Raman M, Earnest S, Zhang K, Zhao Y, Cobb MH. TAO kinases mediate activation of p38 in response to DNA damage. The Embo Journal. 26: 2005-14. PMID 17396146 DOI: 10.1038/Sj.Emboj.7601668 |
0.362 |
|
| 2007 |
Lee BH, Chen W, Stippec S, Cobb MH. Biological cross-talk between WNK1 and the transforming growth factor beta-Smad signaling pathway. The Journal of Biological Chemistry. 282: 17985-96. PMID 17392271 DOI: 10.1074/jbc.M702664200 |
0.35 |
|
| 2007 |
Casar B, Sanz-Moreno V, Yazicioglu MN, RodrÃguez J, Berciano MT, Lafarga M, Cobb MH, Crespo P. Mxi2 promotes stimulus-independent ERK nuclear translocation. The Embo Journal. 26: 635-46. PMID 17255949 DOI: 10.1038/sj.emboj.7601523 |
0.351 |
|
| 2006 |
Wilsbacher JL, Juang YC, Khokhlatchev AV, Gallagher E, Binns D, Goldsmith EJ, Cobb MH. Characterization of mitogen-activated protein kinase (MAPK) dimers. Biochemistry. 45: 13175-82. PMID 17073439 DOI: 10.1021/Bi061041W |
0.349 |
|
| 2006 |
Heise CJ, Cobb MH. Expression and characterization of MAP kinases in bacteria. Methods (San Diego, Calif.). 40: 209-12. PMID 16908184 DOI: 10.1016/j.ymeth.2006.06.012 |
0.427 |
|
| 2006 |
Anselmo AN, Earnest S, Chen W, Juang YC, Kim SC, Zhao Y, Cobb MH. WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 10883-8. PMID 16832045 DOI: 10.1073/Pnas.0604607103 |
0.417 |
|
| 2006 |
Polychronopoulos S, Verykokakis M, Yazicioglu MN, Sakarellos-Daitsiotis M, Cobb MH, Mavrothalassitis G. The transcriptional ETS2 repressor factor associates with active and inactive Erks through distinct FXF motifs. The Journal of Biological Chemistry. 281: 25601-11. PMID 16799155 DOI: 10.1074/jbc.M605185200 |
0.381 |
|
| 2006 |
Ranganathan A, Pearson GW, Chrestensen CA, Sturgill TW, Cobb MH. The MAP kinase ERK5 binds to and phosphorylates p90 RSK. Archives of Biochemistry and Biophysics. 449: 8-16. PMID 16626623 DOI: 10.1016/J.Abb.2006.02.023 |
0.765 |
|
| 2006 |
Ranganathan A, Yazicioglu MN, Cobb MH. The nuclear localization of ERK2 occurs by mechanisms both independent of and dependent on energy. The Journal of Biological Chemistry. 281: 15645-52. PMID 16595679 DOI: 10.1074/jbc.M513866200 |
0.362 |
|
| 2006 |
Pearson GW, Earnest S, Cobb MH. Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals. Molecular and Cellular Biology. 26: 3039-47. PMID 16581779 DOI: 10.1128/MCB.26.8.3039-3047.2006 |
0.783 |
|
| 2006 |
You YJ, Kim J, Cobb M, Avery L. Starvation activates MAP kinase through the muscarinic acetylcholine pathway in Caenorhabditis elegans pharynx. Cell Metabolism. 3: 237-45. PMID 16581001 DOI: 10.1016/J.Cmet.2006.02.012 |
0.337 |
|
| 2006 |
Chen Z, Cobb MH. Activation of MEKK1 by Rho GTPases. Methods in Enzymology. 406: 468-78. PMID 16472679 DOI: 10.1016/S0076-6879(06)06035-6 |
0.432 |
|
| 2005 |
Xu BE, Stippec S, Lazrak A, Huang CL, Cobb MH. WNK1 activates SGK1 by a phosphatidylinositol 3-kinase-dependent and non-catalytic mechanism. The Journal of Biological Chemistry. 280: 34218-23. PMID 16081417 DOI: 10.1074/jbc.M505735200 |
0.393 |
|
| 2005 |
Lenertz LY, Lee BH, Min X, Xu BE, Wedin K, Earnest S, Goldsmith EJ, Cobb MH. Properties of WNK1 and implications for other family members. The Journal of Biological Chemistry. 280: 26653-8. PMID 15883153 DOI: 10.1074/Jbc.M502598200 |
0.327 |
|
| 2005 |
Xu BE, Lee BH, Min X, Lenertz L, Heise CJ, Stippec S, Goldsmith EJ, Cobb MH. WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension. Cell Research. 15: 6-10. PMID 15686619 DOI: 10.1038/Sj.Cr.7290256 |
0.344 |
|
| 2004 |
Whitehurst A, Cobb MH, White MA. Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways. Molecular and Cellular Biology. 24: 10145-50. PMID 15542825 DOI: 10.1128/Mcb.24.23.10145-10150.2004 |
0.756 |
|
| 2004 |
Zhou T, Raman M, Gao Y, Earnest S, Chen Z, Machius M, Cobb MH, Goldsmith EJ. Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K. Structure (London, England : 1993). 12: 1891-900. PMID 15458637 DOI: 10.1016/J.Str.2004.07.021 |
0.38 |
|
| 2004 |
Khoo S, Gibson TB, Arnette D, Lawrence M, January B, McGlynn K, Vanderbilt CA, Griffen SC, German MS, Cobb MH. MAP kinases and their roles in pancreatic beta-cells. Cell Biochemistry and Biophysics. 40: 191-200. PMID 15289654 DOI: 10.1385/CBB:40:3:191 |
0.363 |
|
| 2004 |
Anselmo AN, Cobb MH. Protein kinase function and glutathionylation. The Biochemical Journal. 381: e1-2. PMID 15270699 DOI: 10.1042/BJ20040873 |
0.41 |
|
| 2004 |
Min X, Lee BH, Cobb MH, Goldsmith EJ. Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension. Structure (London, England : 1993). 12: 1303-11. PMID 15242606 DOI: 10.1016/J.Str.2004.04.014 |
0.311 |
|
| 2004 |
Whitehurst AW, Robinson FL, Moore MS, Cobb MH. The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions. The Journal of Biological Chemistry. 279: 12840-7. PMID 14707138 DOI: 10.1074/Jbc.M310031200 |
0.752 |
|
| 2004 |
Chen W, Yazicioglu M, Cobb MH. Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily. The Journal of Biological Chemistry. 279: 11129-36. PMID 14707132 DOI: 10.1074/jbc.M313562200 |
0.448 |
|
| 2004 |
Xu BE, Stippec S, Lenertz L, Lee BH, Zhang W, Lee YK, Cobb MH. WNK1 activates ERK5 by an MEKK2/3-dependent mechanism. The Journal of Biological Chemistry. 279: 7826-31. PMID 14681216 DOI: 10.1074/Jbc.M313465200 |
0.409 |
|
| 2004 |
Gallagher ED, Gutowski S, Sternweis PC, Cobb MH. RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity. The Journal of Biological Chemistry. 279: 1872-7. PMID 14581471 DOI: 10.1074/Jbc.M309525200 |
0.38 |
|
| 2003 |
Khoo S, Griffen SC, Xia Y, Baer RJ, German MS, Cobb MH. Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells. The Journal of Biological Chemistry. 278: 32969-77. PMID 12810726 DOI: 10.1074/jbc.M301198200 |
0.315 |
|
| 2003 |
Arnette D, Gibson TB, Lawrence MC, January B, Khoo S, McGlynn K, Vanderbilt CA, Cobb MH. Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic beta cells. The Journal of Biological Chemistry. 278: 32517-25. PMID 12783880 DOI: 10.1074/jbc.M301174200 |
0.305 |
|
| 2003 |
Chen Z, Raman M, Chen L, Lee SF, Gilman AG, Cobb MH. TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. The Journal of Biological Chemistry. 278: 22278-83. PMID 12665513 DOI: 10.1074/Jbc.M301173200 |
0.418 |
|
| 2002 |
Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, et al. Overview of the Alliance for Cellular Signaling. Nature. 420: 703-6. PMID 12478301 DOI: 10.1038/Nature01304 |
0.414 |
|
| 2002 |
Chen W, White MA, Cobb MH. Stimulus-specific requirements for MAP3 kinases in activating the JNK pathway. The Journal of Biological Chemistry. 277: 49105-10. PMID 12351623 DOI: 10.1074/jbc.M204934200 |
0.416 |
|
| 2002 |
Pearson GW, Cobb MH. Cell condition-dependent regulation of ERK5 by cAMP. The Journal of Biological Chemistry. 277: 48094-8. PMID 12297510 DOI: 10.1074/jbc.M208535200 |
0.787 |
|
| 2002 |
Gallagher ED, Xu S, Moomaw C, Slaughter CA, Cobb MH. Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation. The Journal of Biological Chemistry. 277: 45785-92. PMID 12228228 DOI: 10.1074/jbc.M207702200 |
0.397 |
|
| 2002 |
Christerson LB, Gallagher E, Vanderbilt CA, Whitehurst AW, Wells C, Kazempour R, Sternweis PC, Cobb MH. p115 Rho GTPase activating protein interacts with MEKK1. Journal of Cellular Physiology. 192: 200-8. PMID 12115726 DOI: 10.1002/Jcp.10125 |
0.748 |
|
| 2002 |
Lu Z, Xu S, Joazeiro C, Cobb MH, Hunter T. The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Molecular Cell. 9: 945-56. PMID 12049732 DOI: 10.1016/S1097-2765(02)00519-1 |
0.558 |
|
| 2002 |
Whitehurst AW, Wilsbacher JL, You Y, Luby-Phelps K, Moore MS, Cobb MH. ERK2 enters the nucleus by a carrier-independent mechanism. Proceedings of the National Academy of Sciences of the United States of America. 99: 7496-501. PMID 12032311 DOI: 10.1073/Pnas.112495999 |
0.731 |
|
| 2002 |
Robinson FL, Whitehurst AW, Raman M, Cobb MH. Identification of novel point mutations in ERK2 that selectively disrupt binding to MEK1. The Journal of Biological Chemistry. 277: 14844-52. PMID 11823456 DOI: 10.1074/Jbc.M107776200 |
0.763 |
|
| 2002 |
English JM, Cobb MH. Pharmacological inhibitors of MAPK pathways. Trends in Pharmacological Sciences. 23: 40-5. PMID 11804650 DOI: 10.1016/S0165-6147(00)01865-4 |
0.402 |
|
| 2002 |
Robinson MJ, Xu Be BE, Stippec S, Cobb MH. Different domains of the mitogen-activated protein kinases ERK3 and ERK2 direct subcellular localization and upstream specificity in vivo. The Journal of Biological Chemistry. 277: 5094-100. PMID 11741894 DOI: 10.1074/jbc.M110935200 |
0.37 |
|
| 2001 |
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH. MAP kinases. Chemical Reviews. 101: 2449-76. PMID 11749383 DOI: 10.1021/cr000241p |
0.718 |
|
| 2001 |
Gallagher ED, Cobb MH. ERKs weigh in on ribosome mass. Molecular Cell. 8: 932-3. PMID 11741528 DOI: 10.1016/S1097-2765(01)00387-2 |
0.303 |
|
| 2001 |
Berman KS, Hutchison M, Avery L, Cobb MH. kin-18, a C. elegans protein kinase involved in feeding. Gene. 279: 137-47. PMID 11733138 DOI: 10.1016/S0378-1119(01)00752-1 |
0.397 |
|
| 2001 |
Berman K, McKay J, Avery L, Cobb M. Isolation and characterization of pmk-(1-3): three p38 homologs in Caenorhabditis elegans. Molecular Cell Biology Research Communications : McBrc. 4: 337-44. PMID 11703092 DOI: 10.1006/mcbr.2001.0300 |
0.339 |
|
| 2001 |
Xu Be, Stippec S, Robinson FL, Cobb MH. Hydrophobic as well as charged residues in both MEK1 and ERK2 are important for their proper docking. The Journal of Biological Chemistry. 276: 26509-15. PMID 11352917 DOI: 10.1074/Jbc.M102769200 |
0.308 |
|
| 2001 |
Wilsbacher JL, Cobb MH. Bacterial expression of activated mitogen-activated protein kinases. Methods in Enzymology. 332: 387-400. PMID 11305113 DOI: 10.1016/S0076-6879(01)32217-6 |
0.334 |
|
| 2001 |
Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, Cobb MH. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocrine Reviews. 22: 153-83. PMID 11294822 DOI: 10.1210/Edrv.22.2.0428 |
0.765 |
|
| 2001 |
Chen Z, Cobb MH. Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2. The Journal of Biological Chemistry. 276: 16070-5. PMID 11279118 DOI: 10.1074/jbc.M100681200 |
0.411 |
|
| 2001 |
Pearson G, English JM, White MA, Cobb MH. ERK5 and ERK2 cooperate to regulate NF-kappaB and cell transformation. The Journal of Biological Chemistry. 276: 7927-31. PMID 11118448 DOI: 10.1074/Jbc.M009764200 |
0.758 |
|
| 2000 |
Pearson G, Bumeister R, Henry DO, Cobb MH, White MA. Uncoupling Raf1 from MEK1/2 impairs only a subset of cellular responses to Raf activation. The Journal of Biological Chemistry. 275: 37303-6. PMID 11018021 DOI: 10.1074/Jbc.C000570200 |
0.782 |
|
| 2000 |
Karandikar M, Xu S, Cobb MH. MEKK1 binds raf-1 and the ERK2 cascade components. The Journal of Biological Chemistry. 275: 40120-7. PMID 10969079 DOI: 10.1074/jbc.M005926200 |
0.423 |
|
| 2000 |
Lee HY, Suh YA, Robinson MJ, Clifford JL, Hong WK, Woodgett JR, Cobb MH, Mangelsdorf DJ, Kurie JM. Stress pathway activation induces phosphorylation of retinoid X receptor. The Journal of Biological Chemistry. 275: 32193-9. PMID 10938283 DOI: 10.1074/Jbc.M005490200 |
0.416 |
|
| 2000 |
Xu B, English JM, Wilsbacher JL, Stippec S, Goldsmith EJ, Cobb MH. WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. The Journal of Biological Chemistry. 275: 16795-801. PMID 10828064 DOI: 10.1074/Jbc.275.22.16795 |
0.384 |
|
| 2000 |
Nichols A, Camps M, Gillieron C, Chabert C, Brunet A, Wilsbacher J, Cobb M, Pouyssegur J, Shaw JP, Arkinstall S. Substrate recognition domains within extracellular signal-regulated kinase mediate binding and catalytic activation of mitogen-activated protein kinase phosphatase-3. The Journal of Biological Chemistry. 275: 24613-21. PMID 10811804 DOI: 10.1074/Jbc.M001515200 |
0.501 |
|
| 2000 |
Chaudhary A, King WG, Mattaliano MD, Frost JA, Diaz B, Morrison DK, Cobb MH, Marshall MS, Brugge JS. Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338. Current Biology : Cb. 10: 551-4. PMID 10801448 DOI: 10.1016/S0960-9822(00)00475-9 |
0.406 |
|
| 2000 |
Liou J, Kiefer F, Dang A, Hashimoto A, Cobb MH, Kurosaki T, Weiss A. HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1. Immunity. 12: 399-408. PMID 10795738 DOI: 10.1016/S1074-7613(00)80192-2 |
0.42 |
|
| 2000 |
Frost JA, Swantek JL, Stippec S, Yin MJ, Gaynor R, Cobb MH. Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1. The Journal of Biological Chemistry. 275: 19693-9. PMID 10779525 DOI: 10.1074/jbc.M909860199 |
0.375 |
|
| 2000 |
Cobb MH, Goldsmith EJ. Dimerization in MAP-kinase signaling. Trends in Biochemical Sciences. 25: 7-9. PMID 10637602 DOI: 10.1016/S0968-0004(99)01508-X |
0.391 |
|
| 1999 |
Karandikar M, Cobb MH. Scaffolding and protein interactions in MAP kinase modules. Cell Calcium. 26: 219-26. PMID 10643560 DOI: 10.1054/ceca.1999.0074 |
0.391 |
|
| 1999 |
English J, Pearson G, Wilsbacher J, Swantek J, Karandikar M, Xu S, Cobb MH. New insights into the control of MAP kinase pathways. Experimental Cell Research. 253: 255-70. PMID 10579927 DOI: 10.1006/Excr.1999.4687 |
0.728 |
|
| 1999 |
Xu Be, Wilsbacher JL, Collisson T, Cobb MH. The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo. The Journal of Biological Chemistry. 274: 34029-35. PMID 10567369 DOI: 10.1074/jbc.274.48.34029 |
0.364 |
|
| 1999 |
Wang J, Frost JA, Cobb MH, Ross EM. Reciprocal signaling between heterotrimeric G proteins and the p21-stimulated protein kinase. The Journal of Biological Chemistry. 274: 31641-7. PMID 10531372 DOI: 10.1074/Jbc.274.44.31641 |
0.387 |
|
| 1999 |
English JM, Pearson G, Hockenberry T, Shivakumar L, White MA, Cobb MH. Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control. The Journal of Biological Chemistry. 274: 31588-92. PMID 10531364 DOI: 10.1074/jbc.274.44.31588 |
0.758 |
|
| 1999 |
Chen Z, Hutchison M, Cobb MH. Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain. The Journal of Biological Chemistry. 274: 28803-7. PMID 10497253 DOI: 10.1074/jbc.274.40.28803 |
0.401 |
|
| 1999 |
Christerson LB, Vanderbilt CA, Cobb MH. MEKK1 interacts with alpha-actinin and localizes to stress fibers and focal adhesions. Cell Motility and the Cytoskeleton. 43: 186-98. PMID 10401575 DOI: 10.1002/(SICI)1097-0169(1999)43:3<186::AID-CM2>3.0.CO;2-1 |
0.338 |
|
| 1999 |
Wilsbacher JL, Goldsmith EJ, Cobb MH. Phosphorylation of MAP kinases by MAP/ERK involves multiple regions of MAP kinases. The Journal of Biological Chemistry. 274: 16988-94. PMID 10358048 DOI: 10.1074/Jbc.274.24.16988 |
0.35 |
|
| 1999 |
Cobb MH. MAP kinase pathways. Progress in Biophysics and Molecular Biology. 71: 479-500. PMID 10354710 DOI: 10.1016/S0079-6107(98)00056-X |
0.372 |
|
| 1998 |
Robinson MJ, Stippec SA, Goldsmith E, White MA, Cobb MH. A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation. Current Biology : Cb. 8: 1141-50. PMID 9799732 DOI: 10.1016/S0960-9822(07)00485-X |
0.447 |
|
| 1998 |
Hutchison M, Berman KS, Cobb MH. Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. The Journal of Biological Chemistry. 273: 28625-32. PMID 9786855 DOI: 10.1074/jbc.273.44.28625 |
0.43 |
|
| 1998 |
Wang Z, Canagarajah BJ, Boehm JC, Kassisà S, Cobb MH, Young PR, Abdel-Meguid S, Adams JL, Goldsmith EJ. Structural basis of inhibitor selectivity in MAP kinases. Structure (London, England : 1993). 6: 1117-28. PMID 9753691 DOI: 10.1016/S0969-2126(98)00113-0 |
0.373 |
|
| 1998 |
Dang A, Frost JA, Cobb MH. The MEK1 proline-rich insert is required for efficient activation of the mitogen-activated protein kinases ERK1 and ERK2 in mammalian cells. The Journal of Biological Chemistry. 273: 19909-13. PMID 9677429 DOI: 10.1074/jbc.273.31.19909 |
0.417 |
|
| 1998 |
Yin MJ, Christerson LB, Yamamoto Y, Kwak YT, Xu S, Mercurio F, Barbosa M, Cobb MH, Gaynor RB. HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation. Cell. 93: 875-84. PMID 9630230 DOI: 10.1016/S0092-8674(00)81447-6 |
0.355 |
|
| 1998 |
Khokhlatchev AV, Canagarajah B, Wilsbacher J, Robinson M, Atkinson M, Goldsmith E, Cobb MH. Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation. Cell. 93: 605-15. PMID 9604935 DOI: 10.1016/S0092-8674(00)81189-7 |
0.395 |
|
| 1998 |
English JM, Pearson G, Baer R, Cobb MH. Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases. The Journal of Biological Chemistry. 273: 3854-60. PMID 9461566 DOI: 10.1074/jbc.273.7.3854 |
0.762 |
|
| 1997 |
Xu S, Cobb MH. MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases. The Journal of Biological Chemistry. 272: 32056-60. PMID 9405400 DOI: 10.1074/jbc.272.51.32056 |
0.435 |
|
| 1997 |
Frost JA, Steen H, Shapiro P, Lewis T, Ahn N, Shaw PE, Cobb MH. Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. The Embo Journal. 16: 6426-38. PMID 9351825 DOI: 10.1093/Emboj/16.21.6426 |
0.413 |
|
| 1997 |
Xu S, Khoo S, Dang A, Witt S, Do V, Zhen E, Schaefer EM, Cobb MH. Differential regulation of mitogen-activated protein/ERK kinase (MEK)1 and MEK2 and activation by a Ras-independent mechanism. Molecular Endocrinology (Baltimore, Md.). 11: 1618-25. PMID 9328344 DOI: 10.1210/mend.11.11.0010 |
0.44 |
|
| 1997 |
Canagarajah BJ, Khokhlatchev A, Cobb MH, Goldsmith EJ. Activation mechanism of the MAP kinase ERK2 by dual phosphorylation. Cell. 90: 859-69. PMID 9298898 DOI: 10.1016/S0092-8674(00)80351-7 |
0.334 |
|
| 1997 |
Khoo S, Cobb MH. Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion. Proceedings of the National Academy of Sciences of the United States of America. 94: 5599-604. PMID 9159118 DOI: 10.1073/pnas.94.11.5599 |
0.398 |
|
| 1997 |
Su YC, Han J, Xu S, Cobb M, Skolnik EY. NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. The Embo Journal. 16: 1279-90. PMID 9135144 DOI: 10.1093/emboj/16.6.1279 |
0.339 |
|
| 1997 |
Wang Z, Harkins PC, Ulevitch RJ, Han J, Cobb MH, Goldsmith EJ. The structure of mitogen-activated protein kinase p38 at 2.1-A resolution. Proceedings of the National Academy of Sciences of the United States of America. 94: 2327-32. PMID 9122194 DOI: 10.1073/Pnas.94.6.2327 |
0.338 |
|
| 1997 |
Khokhlatchev A, Xu S, English J, Wu P, Schaefer E, Cobb MH. Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases. The Journal of Biological Chemistry. 272: 11057-62. PMID 9110999 DOI: 10.1074/jbc.272.17.11057 |
0.402 |
|
| 1997 |
Robinson MJ, Cobb MH. Mitogen-activated protein kinase pathways. Current Opinion in Cell Biology. 9: 180-6. PMID 9069255 DOI: 10.1016/S0955-0674(97)80061-0 |
0.429 |
|
| 1996 |
Gilbreth M, Yang P, Wang D, Frost J, Polverino A, Cobb MH, Marcus S. The highly conserved skb1 gene encodes a protein that interacts with Shk1, a fission yeast Ste20/PAK homolog. Proceedings of the National Academy of Sciences of the United States of America. 93: 13802-7. PMID 8943016 DOI: 10.1073/Pnas.93.24.13802 |
0.359 |
|
| 1996 |
Robinson MJ, Cheng M, Khokhlatchev A, Ebert D, Ahn N, Guan KL, Stein B, Goldsmith E, Cobb MH. Contributions of the mitogen-activated protein (MAP) kinase backbone and phosphorylation loop to MEK specificity. The Journal of Biological Chemistry. 271: 29734-9. PMID 8939908 DOI: 10.1074/Jbc.271.47.29734 |
0.36 |
|
| 1996 |
Cobb MH, Xu S, Cheng M, Ebert D, Robbins D, Goldsmith E, Robinson M. Structural analysis of the MAP kinase ERK2 and studies of MAP kinase regulatory pathways. Advances in Pharmacology (San Diego, Calif.). 36: 49-65. PMID 8783554 DOI: 10.1016/S1054-3589(08)60576-1 |
0.609 |
|
| 1996 |
Frost JA, Xu S, Hutchison MR, Marcus S, Cobb MH. Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members. Molecular and Cellular Biology. 16: 3707-13. PMID 8668187 DOI: 10.1128/Mcb.16.7.3707 |
0.424 |
|
| 1996 |
Cheng M, Zhen E, Robinson MJ, Ebert D, Goldsmith E, Cobb MH. Characterization of a protein kinase that phosphorylates serine 189 of the mitogen-activated protein kinase homolog ERK3. The Journal of Biological Chemistry. 271: 12057-62. PMID 8662649 DOI: 10.1074/Jbc.271.20.12057 |
0.403 |
|
| 1996 |
Xu S, Robbins DJ, Christerson LB, English JM, Vanderbilt CA, Cobb MH. Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain. Proceedings of the National Academy of Sciences of the United States of America. 93: 5291-5. PMID 8643568 DOI: 10.1073/pnas.93.11.5291 |
0.527 |
|
| 1996 |
Cheng M, Boulton TG, Cobb MH. ERK3 is a constitutively nuclear protein kinase. The Journal of Biological Chemistry. 271: 8951-8. PMID 8621539 DOI: 10.1074/jbc.271.15.8951 |
0.412 |
|
| 1995 |
Zhai L, Graves PR, Robinson LC, Italiano M, Culbertson MR, Rowles J, Cobb MH, DePaoli-Roach AA, Roach PJ. Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes. The Journal of Biological Chemistry. 270: 12717-24. PMID 7759525 DOI: 10.1074/Jbc.270.21.12717 |
0.3 |
|
| 1995 |
Xu S, Robbins D, Frost J, Dang A, Lange-Carter C, Cobb MH. MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 92: 6808-12. PMID 7624324 DOI: 10.1073/pnas.92.15.6808 |
0.613 |
|
| 1995 |
Marcus S, Polverino A, Chang E, Robbins D, Cobb MH, Wigler MH. Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. Proceedings of the National Academy of Sciences of the United States of America. 92: 6180-4. PMID 7597098 DOI: 10.1073/Pnas.92.13.6180 |
0.604 |
|
| 1995 |
Polverino A, Frost J, Yang P, Hutchison M, Neiman AM, Cobb MH, Marcus S. Activation of mitogen-activated protein kinase cascades by p21-activated protein kinases in cell-free extracts of Xenopus oocytes. The Journal of Biological Chemistry. 270: 26067-70. PMID 7592806 DOI: 10.1074/Jbc.270.44.26067 |
0.399 |
|
| 1995 |
Zhang J, Zhang F, Ebert D, Cobb MH, Goldsmith EJ. Activity of the MAP kinase ERK2 is controlled by a flexible surface loop Structure. 3: 299-307. PMID 7540485 DOI: 10.1016/S0969-2126(01)00160-5 |
0.331 |
|
| 1995 |
English JM, Vanderbilt CA, Xu S, Marcus S, Cobb MH. Isolation of MEK5 and differential expression of alternatively spliced forms. The Journal of Biological Chemistry. 270: 28897-902. PMID 7499418 DOI: 10.1074/Jbc.270.48.28897 |
0.403 |
|
| 1994 |
Frost JA, Geppert TD, Cobb MH, Feramisco JR. A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum. Proceedings of the National Academy of Sciences of the United States of America. 91: 3844-8. PMID 8170999 |
0.305 |
|
| 1994 |
Zhang F, Strand A, Robbins D, Cobb MH, Goldsmith EJ. Atomic structure of the MAP kinase ERK2 at 2.3 A resolution. Nature. 367: 704-11. PMID 8107865 DOI: 10.1038/367704A0 |
0.58 |
|
| 1994 |
Robbins DJ, Zhen E, Cheng M, Xu S, Ebert D, Cobb MH. MAP kinases ERK1 and ERK2: pleiotropic enzymes in a ubiquitous signaling network. Advances in Cancer Research. 63: 93-116. PMID 8036991 |
0.534 |
|
| 1994 |
Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M, Karin M, Brenner DA. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases Proceedings of the National Academy of Sciences of the United States of America. 91: 6030-6034. PMID 8016110 DOI: 10.1073/Pnas.91.13.6030 |
0.301 |
|
| 1994 |
Minden A, Lin A, Smeal T, Dérijard B, Cobb M, Davis R, Karin M. c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases Molecular and Cellular Biology. 14: 6683-6688. PMID 7935387 DOI: 10.1128/mcb.14.10.6683-6688.1994 |
0.345 |
|
| 1994 |
Cobb MH, Xu S, Hepler JE, Hutchison M, Frost J, Robbins DJ. Regulation of the MAP kinase cascade. Cellular & Molecular Biology Research. 40: 253-6. PMID 7874203 |
0.607 |
|
| 1994 |
Cobb MH, Hepler JE, Cheng M, Robbins D. The mitogen-activated protein kinases, ERK1 and ERK2. Seminars in Cancer Biology. 5: 261-8. PMID 7803762 |
0.614 |
|
| 1993 |
Robbins DJ, Zhen E, Owaki H, Vanderbilt CA, Ebert D, Geppert TD, Cobb MH. Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro. The Journal of Biological Chemistry. 268: 5097-106. PMID 8444886 |
0.607 |
|
| 1993 |
Zhang F, Robbins DJ, Cobb MH, Goldsmith EJ. Crystallization and preliminary X-ray studies of extracellular signal-regulated kinase-2/MAP kinase with an incorporated His-tag. Journal of Molecular Biology. 233: 550-2. PMID 8411162 DOI: 10.1006/Jmbi.1993.1532 |
0.589 |
|
| 1993 |
Verlhac MH, De Pennart H, Maro B, Cobb MH, Clarke HJ. MAP kinase becomes stably activated at metaphase and is associated with microtubule-organizing centers during meiotic maturation of mouse oocytes Developmental Biology. 158: 330-340. PMID 8344454 DOI: 10.1006/DBIO.1993.1192 |
0.32 |
|
| 1993 |
Robbins DJ, Zhen E, Cheng M, Xu S, Vanderbilt CA, Ebert D, Garcia C, Dang A, Cobb MH. Regulation and properties of extracellular signal-regulated protein kinases 1, 2, and 3. Journal of the American Society of Nephrology : Jasn. 4: 1104-10. PMID 8305637 |
0.624 |
|
| 1993 |
Sontag E, Fedorov S, Kamibayashi C, Robbins D, Cobb M, Mumby M. The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation. Cell. 75: 887-97. PMID 8252625 DOI: 10.1016/0092-8674(93)90533-V |
0.629 |
|
| 1993 |
Cheng JT, Cobb MH, Baer R. Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1. Molecular and Cellular Biology. 13: 801-808. DOI: 10.1128/MCB.13.2.801 |
0.418 |
|
| 1992 |
Robbins DJ, Cobb MH. Extracellular signal-regulated kinases 2 autophosphorylates on a subset of peptides phosphorylated in intact cells in response to insulin and nerve growth factor: analysis by peptide mapping. Molecular Biology of the Cell. 3: 299-308. PMID 1627831 |
0.61 |
|
| 1992 |
Owaki H, Makar R, Boulton TG, Cobb MH, Geppert TD. Extracellular signal-regulated kinases in T cells: Characterization of human ERK1 and ERK2 cDNAs Biochemical and Biophysical Research Communications. 182: 1416-1422. PMID 1540184 DOI: 10.1016/0006-291X(92)91891-S |
0.373 |
|
| 1992 |
Robbins DJ, Cheng M, Zhen E, Vanderbilt CA, Feig LA, Cobb MH. Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade. Proceedings of the National Academy of Sciences of the United States of America. 89: 6924-8. PMID 1495981 DOI: 10.1073/Pnas.89.15.6924 |
0.546 |
|
| 1992 |
Loeb DM, Tsao H, Cobb MH, Greene LA. NGF and other growth factors induce an association between ERK1 and the NGF receptor, gp140prototrk Neuron. 9: 1053-1065. PMID 1463607 DOI: 10.1016/0896-6273(92)90065-L |
0.329 |
|
| 1992 |
Funasaka Y, Boulton T, Cobb M, Yarden Y, Fan B, Lyman SD, Williams DE, Anderson DM, Zakut R, Mishima Y. c-Kit-kinase induces a cascade of protein tyrosine phosphorylation in normal human melanocytes in response to mast cell growth factor and stimulates mitogen-activated protein kinase but is down-regulated in melanomas. Molecular Biology of the Cell. 3: 197-209. PMID 1372524 DOI: 10.1091/Mbc.3.2.197 |
0.518 |
|
| 1992 |
Haycock JW, Ahn NG, Cobb MH, Krebs EG. ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ. Proceedings of the National Academy of Sciences of the United States of America. 89: 2365-9. PMID 1347949 DOI: 10.1073/Pnas.89.6.2365 |
0.396 |
|
| 1992 |
Shibuya EK, Boulton TG, Cobb MH, Ruderman JV. Activation of p42 MAP kinase and the release of oocytes from cell cycle arrest. The Embo Journal. 11: 3963-75. PMID 1327752 DOI: 10.1002/J.1460-2075.1992.Tb05490.X |
0.374 |
|
| 1992 |
Ahn NG, Robbins DJ, Haycock JW, Seger R, Cobb MH, Krebs EG. Identification of an activator of the microtubule-associated protein 2 kinases ERK1 and ERK2 in PC12 cells stimulated with nerve growth factor or bradykinin. Journal of Neurochemistry. 59: 147-56. PMID 1319464 DOI: 10.1111/J.1471-4159.1992.Tb08885.X |
0.611 |
|
| 1992 |
Lee RM, Cobb MH, Blackshear PJ. Evidence that extracellular signal-regulated kinases are the insulin-activated Raf-1 kinase kinases. Journal of Biological Chemistry. 267: 1088-1092. DOI: 10.1016/s0021-9258(18)48399-8 |
0.422 |
|
| 1991 |
Boulton TG, Nye SH, Robbins DJ, Ip NY, Radziejewska E, Morgenbesser SD, DePinho RA, Panayotatos N, Cobb MH, Yancopoulos GD. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell. 65: 663-75. PMID 2032290 DOI: 10.1016/0092-8674(91)90098-J |
0.615 |
|
| 1991 |
Boulton TG, Gregory JS, Cobb MH. Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase Biochemistry®. 30: 278-286. PMID 1846291 DOI: 10.1021/BI00215A038 |
0.365 |
|
| 1991 |
Cobb MH, Boulton TG, Robbins DJ. Extracellular signal-regulated kinases: ERKs in progress. Cell Regulation. 2: 965-78. PMID 1801927 |
0.591 |
|
| 1991 |
Seger R, Ahn NG, Boulton TG, Yancopoulos GD, Panayotatos N, Radziejewska E, Ericsson L, Bratlien RL, Cobb MH, Krebs EG. Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation. Proceedings of the National Academy of Sciences of the United States of America. 88: 6142-6. PMID 1712480 DOI: 10.1073/Pnas.88.14.6142 |
0.397 |
|
| 1991 |
Cobb MH, Robbins DJ, Boulton TG. ERKs, extracellular signal-regulated MAP-2 kinases. Current Opinion in Cell Biology. 3: 1025-32. PMID 1667578 DOI: 10.1016/0955-0674(91)90124-H |
0.607 |
|
| 1991 |
Boulton TG, Cobb MH. Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies Cell Regulation. 2: 357-371. PMID 1654126 DOI: 10.1091/MBC.2.5.357 |
0.425 |
|
| 1990 |
Boulton TG, Yancopoulos GD, Gregory JS, Slaughter C, Moomaw C, Hsu J, Cobb MH. An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control Science. 249: 64-67. PMID 2164259 DOI: 10.1126/SCIENCE.2164259 |
0.457 |
|
| 1990 |
Yancopoulos GD, Maisonpierre PC, Ip NY, Aldrich TH, Belluscio L, Boulton TG, Cobb MH, Squinto SP, Furth ME. Neurotrophic factors, their receptors, and the signal transduction pathways they activate. Cold Spring Harbor Symposia On Quantitative Biology. 55: 371-9. PMID 1966766 DOI: 10.1101/Sqb.1990.055.01.038 |
0.368 |
|
| 1988 |
Ellis L, Levitan A, Cobb MH, Ramos P. Efficient expression in insect cells of a soluble, active human insulin receptor protein-tyrosine kinase domain by use of a baculovirus vector Journal of Virology. 62: 1634-1639. PMID 2833613 DOI: 10.1128/JVI.62.5.1634-1639.1988 |
0.358 |
|
| 1986 |
Cobb MH, Burr JG, Linder ME, Gray TB, Gregory JS. A similar ribosomal protein S6 kinase activity is found in insulin-treated 3T3-L1 cells and chick embryo fibroblasts transformed by Rous sarcoma virus Biochemical and Biophysical Research Communications. 137: 702-708. PMID 3015127 DOI: 10.1016/0006-291X(86)91135-6 |
0.334 |
|
| 1985 |
Smith RM, Cobb MH, Rosen OM, Jarett L. Ultrastructural analysis of the organization and distribution of insulin receptors on the surface of 3T3-L1 adipocytes: Rapid microaggregation and migration of occupied receptors Journal of Cellular Physiology. 123: 167-179. PMID 3920228 DOI: 10.1002/Jcp.1041230204 |
0.522 |
|
| 1984 |
Cobb MH, Rosen OM. The insulin receptor and tyrosine protein kinase activity Bba - Reviews On Cancer. 738: 1-8. PMID 6331499 DOI: 10.1016/0304-419X(84)90016-7 |
0.623 |
|
| 1983 |
Rosen OM, Herrera R, Olowe Y, Petruzzelli LM, Cobb MH. Phosphorylation activates the insulin receptor tyrosine protein kinase Proceedings of the National Academy of Sciences of the United States of America. 80: 3237-3240. PMID 6574482 DOI: 10.1073/Pnas.80.11.3237 |
0.613 |
|
| 1983 |
Cobb MH, Rosen OM. Description of a protein kinase derived from insulin-treated 3T3-L1 cells that catalyzes the phosphorylation of ribosomal protein S6 and casein. Journal of Biological Chemistry. 258: 12472-12481. DOI: 10.1016/s0021-9258(17)44200-1 |
0.326 |
|
| 1982 |
Petruzzelli LM, Ganguly S, Smith CJ, Cobb MH, Rubin CS, Rosen OM. Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta. Proceedings of the National Academy of Sciences of the United States of America. 79: 6792-6. PMID 6294652 DOI: 10.1073/Pnas.79.22.6792 |
0.725 |
|
| 1981 |
Rosen OM, Rubin CS, Cobb MH, Smith CJ. Insulin stimulates the phosphorylation of ribosomal protein S6 in a cell-free system derived from 3T3-L1 adipocytes. The Journal of Biological Chemistry. 256: 3630-3. PMID 7012140 |
0.679 |
|
| 1980 |
Cobb MH, Heagy W, Danner J, Lenhoff HM, Marshall GR. Effect of glutathione on cyclic nucleotide levels in hydra attenuata Comparative Biochemistry and Physiology. Part C, Comparative. 65: 111-115. DOI: 10.1016/0306-4492(80)90030-1 |
0.435 |
|
| 1978 |
Danner J, Cobb MH, Heagy W, Lenhoff HM, Marshall GR. Interaction of glutathione analogues with Hydra attenuata gamma-glutamyltransferase. The Biochemical Journal. 175: 547-53. PMID 33656 DOI: 10.1042/Bj1750547 |
0.404 |
|
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