David K. Grandy - Publications

Affiliations: 
Physiology and Pharmocology Oregon Health and Science University, Portland, OR 
Area:
Molecular pharmacology of neurotransmitter receptors

127 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Grandy DK, Miller GM, Li JX. "TAARgeting Addiction"-The Alamo Bears Witness to Another Revolution: An Overview of the Plenary Symposium of the 2015 Behavior, Biology and Chemistry Conference. Drug and Alcohol Dependence. PMID 26644139 DOI: 10.1016/j.drugalcdep.2015.11.014  0.96
2015 Soto PL, Hiranita T, Xu M, Hursh SR, Grandy DK, Katz JL. Dopamine D2-Like Receptors and Behavioral Economics of Food Reinforcement. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26205210 DOI: 10.1038/npp.2015.223  0.96
2015 Delis F, Rombola C, Bellezza R, Rosko L, Grandy DK, Volkow ND, Thanos PK. Regulation of ethanol intake under chronic mild stress: roles of dopamine receptors and transporters. Frontiers in Behavioral Neuroscience. 9: 118. PMID 26029066 DOI: 10.3389/fnbeh.2015.00118  0.96
2015 Thanos PK, Roushdy K, Sarwar Z, Rice O, Ashby CR, Grandy DK. The effect of dopamine D4 receptor density on novelty seeking, activity, social interaction, and alcohol binge drinking in adult mice. Synapse (New York, N.Y.). 69: 356-64. PMID 25914336 DOI: 10.1002/syn.21822  0.96
2014 Grandy DK. TAAR1 transforms thinking about a plant alkaloid that transformed the practice of medicine. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 17: 1545-7. PMID 24901712 DOI: 10.1017/S1461145714000911  0.96
2014 Liu X, Grandy DK, Janowsky A. Ractopamine, a livestock feed additive, is a full agonist at trace amine-associated receptor 1. The Journal of Pharmacology and Experimental Therapeutics. 350: 124-9. PMID 24799633 DOI: 10.1124/jpet.114.213116  0.96
2014 Soto PL, Hiranita T, Grandy DK, Katz JL. Choice for response alternatives differing in reinforcement frequency in dopamine D2 receptor mutant and Swiss-Webster mice. Psychopharmacology. 231: 3169-77. PMID 24682471 DOI: 10.1007/s00213-014-3495-4  0.96
2014 Di Ciano P, Grandy DK, Le Foll B. Dopamine D4 receptors in psychostimulant addiction. Advances in Pharmacology (San Diego, Calif.). 69: 301-21. PMID 24484981 DOI: 10.1016/B978-0-12-420118-7.00008-1  0.96
2014 Reese EA, Norimatsu Y, Grandy MS, Suchland KL, Bunzow JR, Grandy DK. Exploring the determinants of trace amine-associated receptor 1's functional selectivity for the stereoisomers of amphetamine and methamphetamine. Journal of Medicinal Chemistry. 57: 378-90. PMID 24354319 DOI: 10.1021/jm401316v  0.96
2014 Desai RI, Grandy DK, Lupica CR, Katz JL. Pharmacological characterization of a dopamine transporter ligand that functions as a cocaine antagonist. The Journal of Pharmacology and Experimental Therapeutics. 348: 106-15. PMID 24194528 DOI: 10.1124/jpet.113.208538  0.96
2013 Keck TM, Suchland KL, Jimenez CC, Grandy DK. Dopamine D4 receptor deficiency in mice alters behavioral responses to anxiogenic stimuli and the psychostimulant methylphenidate. Pharmacology, Biochemistry, and Behavior. 103: 831-41. PMID 23262298 DOI: 10.1016/j.pbb.2012.12.006  0.96
2012 Tallman KR, Grandy DK. A decade of pharma discovery delivers new tools targeting trace amine-associated receptor 1. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 2553-4. PMID 23070201 DOI: 10.1038/npp.2012.148  0.96
2012 Yang Y, Zhang Y, Cuevas S, Villar VA, Escano C, D Asico L, Yu P, Grandy DK, Felder RA, Armando I, Jose PA. Paraoxonase 2 decreases renal reactive oxygen species production, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of NADPH oxidase. Free Radical Biology & Medicine. 53: 437-46. PMID 22634053 DOI: 10.1016/j.freeradbiomed.2012.05.015  0.96
2012 Maison SF, Liu XP, Eatock RA, Sibley DR, Grandy DK, Liberman MC. Dopaminergic signaling in the cochlea: receptor expression patterns and deletion phenotypes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 344-55. PMID 22219295 DOI: 10.1523/JNEUROSCI.4720-11.2012  0.96
2011 Soto PL, Grandy DK, Hursh SR, Katz JL. Behavioral economics of food reinforcement and the effects of prefeeding, extinction, and eticlopride in dopamine D2 receptor mutant mice. Psychopharmacology. 215: 775-84. PMID 21287342 DOI: 10.1007/s00213-011-2173-z  0.96
2011 Thanos PK, Gopez V, Delis F, Michaelides M, Grandy DK, Wang GJ, Kunos G, Volkow ND. Upregulation of cannabinoid type 1 receptors in dopamine D2 receptor knockout mice is reversed by chronic forced ethanol consumption. Alcoholism, Clinical and Experimental Research. 35: 19-27. PMID 20958329 DOI: 10.1111/j.1530-0277.2010.01318.x  0.96
2010 Michaelides M, Pascau J, Gispert JD, Delis F, Grandy DK, Wang GJ, Desco M, Rubinstein M, Volkow ND, Thanos PK. Dopamine D4 receptors modulate brain metabolic activity in the prefrontal cortex and cerebellum at rest and in response to methylphenidate. The European Journal of Neuroscience. 32: 668-76. PMID 20646063 DOI: 10.1111/j.1460-9568.2010.07319.x  0.96
2010 Li SM, Collins GT, Paul NM, Grundt P, Newman AH, Xu M, Grandy DK, Woods JH, Katz JL. Yawning and locomotor behavior induced by dopamine receptor agonists in mice and rats. Behavioural Pharmacology. 21: 171-81. PMID 20463460 DOI: 10.1097/FBP.0b013e32833a5c68  0.96
2010 Thanos PK, Habibi R, Michaelides M, Patel UB, Suchland K, Anderson BJ, Robinson JK, Wang GJ, Grandy DK, Volkow ND. Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine. Behavioural Brain Research. 207: 508-11. PMID 19853629 DOI: 10.1016/j.bbr.2009.10.020  0.96
2009 Wang HD, Stanwood GD, Grandy DK, Deutch AY. Dystrophic dendrites in prefrontal cortical pyramidal cells of dopamine D1 and D2 but not D4 receptor knockout mice. Brain Research. 1300: 58-64. PMID 19747903 DOI: 10.1016/j.brainres.2009.09.008  0.96
2009 Ghelardoni S, Suffredini S, Frascarelli S, Brogioni S, Chiellini G, Ronca-Testoni S, Grandy DK, Scanlan TS, Cerbai E, Zucchi R. Modulation of cardiac ionic homeostasis by 3-iodothyronamine Journal of Cellular and Molecular Medicine. 13: 3082-3090. PMID 19298522 DOI: 10.1111/j.1582-4934.2009.00728.x  0.96
2009 Klieverik LP, Foppen E, Ackermans MT, Serlie MJ, Sauerwein HP, Scanlan TS, Grandy DK, Fliers E, Kalsbeek A. Central effects of thyronamines on glucose metabolism in rats. The Journal of Endocrinology. 201: 377-86. PMID 19273499 DOI: 10.1677/JOE-09-0043  0.96
2009 Tan ES, Naylor JC, Groban ES, Bunzow JR, Jacobson MP, Grandy DK, Scanlan TS. The molecular basis of species-specific ligand activation of trace amine-associated receptor 1 (TAAR(1)). Acs Chemical Biology. 4: 209-20. PMID 19256523 DOI: 10.1021/cb800304d  0.96
2009 Collins GT, Truccone A, Haji-Abdi F, Newman AH, Grundt P, Rice KC, Husbands SM, Greedy BM, Enguehard-Gueiffier C, Gueiffier A, Chen J, Wang S, Katz JL, Grandy DK, Sunahara RK, et al. Proerectile effects of dopamine D2-like agonists are mediated by the D3 receptor in rats and mice. The Journal of Pharmacology and Experimental Therapeutics. 329: 210-7. PMID 19136638 DOI: 10.1124/jpet.108.144048  0.96
2009 Thomas TC, Grandy DK, Gerhardt GA, Glaser PE. Decreased dopamine D4 receptor expression increases extracellular glutamate and alters its regulation in mouse striatum. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 436-45. PMID 18536704 DOI: 10.1038/npp.2008.74  0.96
2008 Frascarelli S, Ghelardoni S, Chiellini G, Vargiu R, Ronca-Testoni S, Scanlan TS, Grandy DK, Zucchi R. Cardiac effects of trace amines: Pharmacological characterization of trace amine-associated receptors European Journal of Pharmacology. 587: 231-236. PMID 18486124 DOI: 10.1016/j.ejphar.2008.03.055  0.96
2007 Grandy DK. Trace amine-associated receptor 1-Family archetype or iconoclast? Pharmacology & Therapeutics. 116: 355-90. PMID 17888514 DOI: 10.1016/j.pharmthera.2007.06.007  0.96
2007 Doyle KP, Suchland KL, Ciesielski TMP, Lessov NS, Grandy DK, Scanlan TS, Stenzel-Poore MP. Novel thyroxine derivatives, thyronamine and 3-iodothyronamine, induce transient hypothermia and marked neuroprotection against stroke injury Stroke. 38: 2569-2576. PMID 17690312 DOI: 10.1161/STROKEAHA.106.480277  0.96
2007 Tan ES, Miyakawa M, Bunzow JR, Grandy DK, Scanlan TS. Exploring the structure-activity relationship of the ethylamine portion of 3-iodothyronamine for rat and mouse trace amine-associated receptor 1 Journal of Medicinal Chemistry. 50: 2787-2798. PMID 17497842 DOI: 10.1021/jm0700417  0.96
2007 Thomas TC, Kruzich PJ, Joyce BM, Gash CR, Suchland K, Surgener SP, Rutherford EC, Grandy DK, Gerhardt GA, Glaser PE. Dopamine D4 receptor knockout mice exhibit neurochemical changes consistent with decreased dopamine release. Journal of Neuroscience Methods. 166: 306-14. PMID 17449106 DOI: 10.1016/j.jneumeth.2007.03.009  0.96
2007 Chiellini G, Frascarelli S, Ghelardoni S, Carnicelli V, Tobias SC, DeBarber A, Brogioni S, Ronca-Testoni S, Cerbai E, Grandy DK, Scanlan TS, Zucchi R. Cardiac effects of 3-iodothyronamine: A new aminergic system modulating cardiac function Faseb Journal. 21: 1597-1608. PMID 17284482 DOI: 10.1096/fj.06-7474com  0.96
2006 Kruzich PJ, Mitchell SH, Younkin A, Grandy DK. Dopamine D2 receptors mediate reversal learning in male C57BL/6J mice. Cognitive, Affective & Behavioral Neuroscience. 6: 86-90. PMID 16869233 DOI: 10.3758/CABN.6.1.86  0.96
2006 Hart ME, Suchland KL, Miyakawa M, Bunzow JR, Grandy DK, Scanlan TS. Trace amine-associated receptor agonists: Synthesis and evaluation of thyronamines and related analogues Journal of Medicinal Chemistry. 49: 1101-1112. PMID 16451074 DOI: 10.1021/jm0505718  0.96
2006 Tomiyama K, Makihara Y, Yamamoto H, O'Sullivan G, Nally RE, Tighe O, Kinsella A, Fienberg AA, Grandy DK, Sibley DR, Croke DT, Koshikawa N, Waddington JL. Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction 'knockout'. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 16: 437-45. PMID 16413758 DOI: 10.1016/j.euroneuro.2005.11.012  0.96
2006 Bek MJ, Wang X, Asico LD, Jones JE, Zheng S, Li X, Eisner GM, Grandy DK, Carey RM, Soares-da-Silva P, Jose PA. Angiotensin-II type 1 receptor-mediated hypertension in D4 dopamine receptor-deficient mice. Hypertension. 47: 288-95. PMID 16380537 DOI: 10.1161/01.HYP.0000198427.96225.36  0.96
2006 O'Sullivan GJ, Kinsella A, Grandy DK, Tighe O, Croke DT, Waddington JL. Ethological resolution of behavioral topography and D2-like vs. D1-like agonist responses in congenic D4 dopamine receptor "knockouts": identification of D4:D1-like interactions. Synapse (New York, N.Y.). 59: 107-18. PMID 16320306 DOI: 10.1002/syn.20225  0.96
2005 Kachroo A, Orlando LR, Grandy DK, Chen JF, Young AB, Schwarzschild MA. Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10414-9. PMID 16280580 DOI: 10.1523/JNEUROSCI.3660-05.2005  0.96
2005 Thanos PK, Rivera SN, Weaver K, Grandy DK, Rubinstein M, Umegaki H, Wang GJ, Hitzemann R, Volkow ND. Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: effects on ethanol drinking. Life Sciences. 77: 130-9. PMID 15862598 DOI: 10.1016/j.lfs.2004.10.061  0.96
2005 Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC. Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. Genomics. 85: 372-85. PMID 15718104 DOI: 10.1016/j.ygeno.2004.11.010  0.96
2005 Seeman P, Weinshenker D, Quirion R, Srivastava LK, Bhardwaj SK, Grandy DK, Premont RT, Sotnikova TD, Boksa P, El-Ghundi M, O'dowd BF, George SR, Perreault ML, Männistö PT, Robinson S, et al. Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis. Proceedings of the National Academy of Sciences of the United States of America. 102: 3513-8. PMID 15716360 DOI: 10.1073/pnas.0409766102  0.96
2005 Swanson JM, Volkow ND, Newcorn J, Casey BJ, Moyzis R, Grandy DK, Posner MI. Dopamine and glutamate in attention deficit hyperactivity disorder Dopamine and Glutamate in Psychiatric Disorders. 293-315. DOI: 10.1007/978-1-59259-852-6_13  0.96
2004 Beckstead MJ, Grandy DK, Wickman K, Williams JT. Vesicular dopamine release elicits an inhibitory postsynaptic current in midbrain dopamine neurons. Neuron. 42: 939-46. PMID 15207238 DOI: 10.1016/j.neuron.2004.05.019  0.96
2004 Kruzich PJ, Suchland KL, Grandy DK. Dopamine D4 receptor-deficient mice, congenic on the C57BL/6J background, are hypersensitive to amphetamine. Synapse (New York, N.Y.). 53: 131-9. PMID 15170825 DOI: 10.1002/syn.20043  0.96
2004 Scanlan TS, Suchland KL, Hart ME, Chiellini G, Huang Y, Kruzich PJ, Frascarelli S, Crossley DA, Bunzow JR, Ronca-Testoni S, Lin ET, Hatton D, Zucchi R, Grandy DK. 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone Nature Medicine. 10: 638-642. PMID 15146179 DOI: 10.1038/nm1051  0.96
2004 Kruzich PJ, Grandy DK. Dopamine D2 receptors mediate two-odor discrimination and reversal learning in C57BL/6 mice. Bmc Neuroscience. 5: 12. PMID 15061865 DOI: 10.1186/1471-2202-5-12  0.96
2004 Tomiyama K, McNamara FN, Clifford JJ, Kinsella A, Drago J, Fuchs S, Grandy DK, Low MJ, Rubinstein M, Tighe O, Croke DT, Koshikawa N, Waddington JL. Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout". Synapse (New York, N.Y.). 51: 71-81. PMID 14579426 DOI: 10.1002/syn.10284  0.96
2003 Qiu J, Bosch MA, Tobias SC, Grandy DK, Scanlan TS, Rønnekleiv OK, Kelly MJ. Rapid Signaling of Estrogen in Hypothalamic Neurons Involves a Novel G-Protein-Coupled Estrogen Receptor that Activates Protein Kinase C Journal of Neuroscience. 23: 9529-9540. PMID 14573532  0.96
2003 Palmer AA, Low MJ, Grandy DK, Phillips TJ. Effects of a Drd2 deletion mutation on ethanol-induced locomotor stimulation and sensitization suggest a role for epistasis. Behavior Genetics. 33: 311-24. PMID 12837020 DOI: 10.1023/A:1023450625826  0.96
2003 Katz JL, Chausmer AL, Elmer GI, Rubinstein M, Low MJ, Grandy DK. Cocaine-induced locomotor activity and cocaine discrimination in dopamine D4 receptor mutant mice. Psychopharmacology. 170: 108-14. PMID 12783155 DOI: 10.1007/s00213-003-1513-z  0.96
2002 Thanos PK, Taintor NB, Alexoff D, Vaska P, Logan J, Grandy DK, Fang Y, Lee JH, Fowler JS, Volkow ND, Rubinstein M. In vivo comparative imaging of dopamine D2 knockout and wild-type mice with (11)C-raclopride and microPET. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 43: 1570-7. PMID 12411561  0.96
2002 Chausmer AL, Elmer GI, Rubinstein M, Low MJ, Grandy DK, Katz JL. Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant mice. Psychopharmacology. 163: 54-61. PMID 12185400 DOI: 10.1007/s00213-002-1142-y  0.96
2002 Zheng F, Grandy DK, Johnson SW. Actions of orphanin FQ/nociceptin on rat ventral tegmental area neurons in vitro. British Journal of Pharmacology. 136: 1065-71. PMID 12145107 DOI: 10.1038/sj.bjp.0704806  0.96
2002 Li X, Bek M, Asico LD, Yang Z, Rubinstein M, Grandy DK, Goldstein DS, Eisner GM, Jose PA. [Disruption of the D(2) dopamine receptor produces adrenergic and endothelin B receptor-dependent hypertension]. Zhonghua Yi Xue Za Zhi. 82: 703-7. PMID 12133472  0.96
2002 Alvarez VA, Arttamangkul S, Dang V, Salem A, Whistler JL, Von Zastrow M, Grandy DK, Williams JT. mu-Opioid receptors: Ligand-dependent activation of potassium conductance, desensitization, and internalization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 5769-76. PMID 12097530  0.96
2002 Elmer GI, Pieper JO, Rubinstein M, Low MJ, Grandy DK, Wise RA. Failure of intravenous morphine to serve as an effective instrumental reinforcer in dopamine D2 receptor knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: RC224. PMID 12006606  0.96
2002 Li M, Li C, Weingarten P, Bunzow JR, Grandy DK, Zhou QY. Association of dopamine D(3) receptors with actin-binding protein 280 (ABP-280). Biochemical Pharmacology. 63: 859-63. PMID 11911837 DOI: 10.1016/S0006-2952(01)00932-7  0.96
2002 Rivera A, Cuéllar B, Girón FJ, Grandy DK, de la Calle A, Moratalla R. Dopamine D4 receptors are heterogeneously distributed in the striosomes/matrix compartments of the striatum. Journal of Neurochemistry. 80: 219-29. PMID 11902112 DOI: 10.1046/j.0022-3042.2001.00702.x  0.96
2002 Nir I, Harrison JM, Haque R, Low MJ, Grandy DK, Rubinstein M, Iuvone PM. Dysfunctional light-evoked regulation of cAMP in photoreceptors and abnormal retinal adaptation in mice lacking dopamine D4 receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 2063-73. PMID 11896146  0.96
2002 Falzone TL, Gelman DM, Young JI, Grandy DK, Low MJ, Rubinstein M. Absence of dopamine D4 receptors results in enhanced reactivity to unconditioned, but not conditioned, fear. The European Journal of Neuroscience. 15: 158-64. PMID 11860516 DOI: 10.1046/j.0953-816x.2001.01842.x  0.96
1999 Allen CN, Jiang ZG, Teshima K, Darland T, Ikeda M, Nelson CS, Quigley DI, Yoshioka T, Allen RG, Rea MA, Grandy DK. Orphanin-FQ/nociceptin (OFQ/N) modulates the activity of suprachiasmatic nucleus neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 2152-60. PMID 10066268  0.96
1999 Hirota K, Okawa H, Appadu BL, Grandy DK, Devi LA, Lambert DG. Stereoselective interaction of ketamine with recombinant mu, kappa, and delta opioid receptors expressed in Chinese hamster ovary cells. Anesthesiology. 90: 174-82. PMID 9915326  0.96
1999 Dickinson SD, Sabeti J, Larson GA, Giardina K, Rubinstein M, Kelly MA, Grandy DK, Low MJ, Gerhardt GA, Zahniser NR. Dopamine D2 receptor-deficient mice exhibit decreased dopamine transporter function but no changes in dopamine release in dorsal striatum. Journal of Neurochemistry. 72: 148-56. PMID 9886065 DOI: 10.1046/j.1471-4159.1999.0720148.x  0.96
1998 Low MJ, Kelly MA, Rubinstein M, Grandy DK. Single genes and complex phenotypes. Molecular Psychiatry. 3: 373-7. PMID 9774768  0.96
1998 Darland T, Grandy DK. The orphanin FQ system: An emerging target for the management of pain? British Journal of Anaesthesia. 81: 29-37. PMID 9771270  0.96
1998 Kidd KK, Morar B, Castiglione CM, Zhao H, Pakstis AJ, Speed WC, Bonne-Tamir B, Lu RB, Goldman D, Lee C, Nam YS, Grandy DK, Jenkins T, Kidd JR. A global survey of haplotype frequencies and linkage disequilibrium at the DRD2 locus. Human Genetics. 103: 211-27. PMID 9760208 DOI: 10.1007/s004390050809  0.96
1998 Lambert DG, Grandy DK. Orphanin FQ/nociceptin: An endogenous peptide agonist for the orphan opioid receptor British Journal of Anaesthesia. 80: 577-578. PMID 9691856  0.96
1998 Tian JH, Zhang W, Fang Y, Xu W, Grandy DK, Han JS. Endogenous orphanin FQ: Evidence for a role in the modulation of electroacupuncture analgesia and the development of tolerance to analgesia produced by morphine and electroacupuncture British Journal of Pharmacology. 124: 21-26. PMID 9630338 DOI: 10.1038/sj.bjp.0701788  0.96
1998 Darland T, Heinricher MM, Grandy DK. Orphanin FQ/nociceptin: a role in pain and analgesia, but so much more. Trends in Neurosciences. 21: 215-21. PMID 9610886 DOI: 10.1016/S0166-2236(97)01204-6  0.96
1998 Kelly MA, Rubinstein M, Phillips TJ, Lessov CN, Burkhart-Kasch S, Zhang G, Bunzow JR, Fang Y, Gerhardt GA, Grandy DK, Low MJ. Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 3470-9. PMID 9547254  0.96
1998 Wagner EJ, Rønnekleiv OK, Grandy DK, Kelly MJ. The peptide orphanin FQ inhibits beta-endorphin neurons and neurosecretory cells in the hypothalamic arcuate nucleus by activating an inwardly-rectifying K+ conductance. Neuroendocrinology. 67: 73-82. PMID 9508037 DOI: 10.1159/000054301  0.96
1998 Quigley DI, McDougall J, Darland T, Zhang G, Ronnekliev O, Grandy DK, Allen RG. Orphanin FQ is the major OFQ1-17-containing peptide produced in the rodent and monkey hypothalamus. Peptides. 19: 133-9. PMID 9437745 DOI: 10.1016/S0196-9781(97)00268-4  0.96
1998 Low MJ, Kelly MA, Rubinstein M, Grandy DK. Single genes and complex phenotypes Molecular Psychiatry. 3: 375-377.  0.96
1998 Phillips TJ, Brown KJ, Burkhart-Kasch S, Wenger CD, Kelly MA, Rubinstein M, Grandy DK, Low MJ. Alcohol preference and sensitivity are markedly reduced in mice lacking dopamine D2 receptors Molecular Cell. 1: 610-615.  0.96
1998 Juarez RA, Bryan C, Kelly MA, Grandy DK, Low MJ. Ventilatory response in dopamine D2 receptor - Deficient mice (D2R -/-) Faseb Journal. 12: A979.  0.96
1997 Morgan MM, Grisel JE, Robbins CS, Grandy DK. Antinociception mediated by the periaqueductal gray is attenuated by orphanin FQ. Neuroreport. 8: 3431-4. PMID 9427301  0.96
1997 Zhang G, Murray TF, Grandy DK. Orphanin FQ has an inhibitory effect on the guinea pig ileum and the mouse vas deferens Brain Research. 772: 102-106. PMID 9406961 DOI: 10.1016/S0006-8993(97)00858-5  0.96
1997 Heinricher MM, McGaraughty S, Grandy DK. Circuitry underlying antiopioid actions of orphanin FQ in the rostral ventromedial medulla. Journal of Neurophysiology. 78: 3351-8. PMID 9405549  0.96
1997 Nah SY, Unteutsch A, Bunzow JR, Cook SP, Beacham DW, Grandy DK. Mu and delta opioids but not kappa opioid inhibit voltage-activated Ba2+ currents in neuronal F-11 cell. Brain Research. 766: 66-71. PMID 9359588 DOI: 10.1016/S0006-8993(97)00537-4  0.96
1997 Rubinstein M, Phillips TJ, Bunzow JR, Falzone TL, Dziewczapolski G, Zhang G, Fang Y, Larson JL, McDougall JA, Chester JA, Saez C, Pugsley TA, Gershanik O, Low MJ, Grandy DK. Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell. 90: 991-1001. PMID 9323127 DOI: 10.1016/S0092-8674(00)80365-7  0.96
1997 Hirst RA, Hirota K, Grandy DK, Lambert DG. Coupling of the cloned rat κ-opioid receptor to adenylyl cyclase is dependent on receptor expression Neuroscience Letters. 232: 119-122. PMID 9302101 DOI: 10.1016/S0304-3940(97)00594-6  0.96
1997 Kelly MA, Rubinstein M, Asa SL, Zhang G, Saez C, Bunzow JR, Allen RG, Hnasko R, Ben-Jonathan N, Grandy DK, Low MJ. Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice. Neuron. 19: 103-13. PMID 9247267 DOI: 10.1016/S0896-6273(00)80351-7  0.96
1997 Smart D, Hirst RA, Hirota K, Grandy DK, Lambert DG. The effects of recombinant rat μ-opioid receptor activation in CHO cells on phospholipase C, [Ca2+](i) and adenylyl cyclase British Journal of Pharmacology. 120: 1165-1171. PMID 9134231 DOI: 10.1038/sj.bjp.0701012  0.96
1997 Arttamangkul S, Ishmael JE, Murray TF, Grandy DK, DeLander GE, Kieffer BL, Aldrich JV. Synthesis and opioid activity of conformationally constrained dynorphin A analogues. 2. Conformational constraint in the "address" sequence. Journal of Medicinal Chemistry. 40: 1211-8. PMID 9111295 DOI: 10.1021/jm960753p  0.96
1997 Tian JH, Xu W, Zhang W, Fang Y, Grisel JE, Mogil JS, Grandy DK, Han JS. Involvement of endogenous orphanin FQ in electroacupuncture-induced analgesia. Neuroreport. 8: 497-500. PMID 9080436  0.96
1997 Tian JH, Xu W, Fang Y, Mogil JS, Grisel JE, Grandy DK, Han JS. Bidirectional modulatory effect of orphanin FQ on morphine-induced analgesia: antagonism in brain and potentiation in spinal cord of the rat. British Journal of Pharmacology. 120: 676-80. PMID 9051307 DOI: 10.1038/sj.bjp.0700942  0.96
1997 Hirota K, Appadu BL, Grandy DK, Devi LA, Lambert DG. Effects of ketamine on cAMP formation in Chinese hamster ovary cells expressing recombinant opioid receptors British Journal of Anaesthesia. 79: 141P.  0.96
1996 Mogil JS, Grisel JE, Reinscheid RK, Civelli O, Belknap JK, Grandy DK. Orphanin FQ is a functional anti-opioid peptide. Neuroscience. 75: 333-7. PMID 8930999 DOI: 10.1016/0306-4522(96)00338-7  0.96
1996 Grisel JE, Mogil JS, Belknap JK, Grandy DK. Orphanin FQ acts as a supraspinal, but not a spinal, anti-opioid peptide. Neuroreport. 7: 2125-9. PMID 8930972  0.96
1996 Rønnekleiv OK, Bosch MA, Cunningham MJ, Wagner EJ, Grandy DK, Kelly MJ. Downregulation of mu-opioid receptor mRNA in the mediobasal hypothalamus of the female guinea pig following morphine treatment. Neuroscience Letters. 216: 129-32. PMID 8904800 DOI: 10.1016/S0304-3940(96)13033-0  0.96
1996 Mogil JS, Grisel JE, Zhangs G, Belknap JK, Grandy DK. Functional antagonism of mu-, delta- and kappa-opioid antinociception by orphanin FQ. Neuroscience Letters. 214: 131-4. PMID 8878101 DOI: 10.1016/0304-3940(96)12917-7  0.96
1995 Castiglione CM, Deinard AS, Speed WC, Sirugo G, Rosenbaum HC, Zhang Y, Grandy DK, Grigorenko EL, Bonne-Tamir B, Pakstis AJ. Evolution of haplotypes at the DRD2 locus. American Journal of Human Genetics. 57: 1445-56. PMID 8533775  0.96
1995 Bunzow JR, Zhang G, Bouvier C, Saez C, Ronnekleiv OK, Kelly MJ, Grandy DK. Characterization and distribution of a cloned rat mu-opioid receptor. Journal of Neurochemistry. 64: 14-24. PMID 7798908  0.96
1995 Kimura K, Sela S, Bouvier C, Grandy DK, Sidhu A. Differential coupling of D1 and D5 dopamine receptors to guanine nucleotide binding proteins in transfected GH4C1 rat somatomammotrophic cells Journal of Neurochemistry. 64: 2118-2124. PMID 7722495  0.96
1995 Henry DJ, Grandy DK, Lester HA, Davidson N, Chavkin C. Kappa-opioid receptors couple to inwardly rectifying potassium channels when coexpressed by Xenopus oocytes. Molecular Pharmacology. 47: 551-7. PMID 7700253  0.96
1995 Bouvier C, Bunzow JR, Guan HC, Unteutsch A, Civelli O, Grandy DK, Van Tol HH. Functional characterization of the human dopamine D4.2 receptor using vaccinia virus as an expression system. European Journal of Pharmacology. 290: 11-7. PMID 7664820 DOI: 10.1016/0922-4106(95)90011-X  0.96
1995 Hjorth SA, Thirstrup K, Grandy DK, Schwartz TW. Analysis of selective binding epitopes for the kappa-opioid receptor antagonist nor-binaltorphimine. Molecular Pharmacology. 47: 1089-94. PMID 7541509  0.96
1995 Reinscheid RK, Nothacker HP, Bourson A, Ardati A, Henningsen RA, Bunzow JR, Grandy DK, Langen H, Monsma FJ, Civelli O. Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor. Science (New York, N.Y.). 270: 792-4. PMID 7481766  0.96
1995 Grandy DK, Zhou QY, Bouvier C, Saez C, Bunzow JR. [5] Cloning of G protein-coupled opioid receptors using degenerate PCR and low-stringency homology screening Methods in Neurosciences. 25: 90-104. DOI: 10.1016/S1043-9471(05)80035-7  0.96
1994 Noble EP, Noble RE, Ritchie T, Syndulko K, Bohlman MC, Noble LA, Zhang Y, Sparkes RS, Grandy DK. D2 dopamine receptor gene and obesity International Journal of Eating Disorders. 15: 205-217. PMID 8199600  0.96
1994 Bunzow JR, Saez C, Mortrud M, Bouvier C, Williams JT, Low M, Grandy DK. Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta or kappa opioid receptor type. Febs Letters. 347: 284-8. PMID 8034019 DOI: 10.1016/0014-5793(94)00561-3  0.96
1994 Bouvier C, Unteutsch A, Hagen S, Zhu WZ, Bunzow JR, Grandy DK. Agonist properties of methadone at the cloned rat μ opioid receptor Regulatory Peptides. 54: 31-32. DOI: 10.1016/0167-0115(94)90374-3  0.96
1994 Saez C, Zhou QY, Civelli O, Bunzow JR, Grandy DK. Distribution of mRNA encoding a novel opioid receptor in mouse brain Regulatory Peptides. 53: S13-S14. DOI: 10.1016/0167-0115(94)90217-8  0.96
1993 Civelli O, Bunzow JR, Grandy DK. Molecular diversity of the dopamine receptors. Annual Review of Pharmacology and Toxicology. 33: 281-307. PMID 8494342 DOI: 10.1146/annurev.pa.33.040193.001433  0.96
1993 Gelernter J, Kennedy JL, Grandy DK, Zhou QY, Civelli O, Pauls DL, Pakstis A, Kurlan R, Sunahara RK, Niznik HB. Exclusion of close linkage of Tourette's syndrome to D1 dopamine receptor. The American Journal of Psychiatry. 150: 449-53. PMID 8434661  0.96
1993 Nöthen MM, Körner J, Lannfelt L, Sokoloff P, Schwartz JC, Lanczik M, Rietschel M, Cichon S, Kramer R, Fimmers R, Möller HJ, Beckmann H, Propping P, Grandy DK, Civelli O, et al. Lack of association between schizophrenia and alleles of the dopamine D1, D2, D3 and D4 receptor loci Psychiatric Genetics. 3: 89-94.  0.96
1992 Grandy DK, Civelli O. G-protein-coupled receptors: the new dopamine receptor subtypes. Current Opinion in Neurobiology. 2: 275-81. PMID 1643409 DOI: 10.1016/0959-4388(92)90115-2  0.96
1992 Civelli O, Bunzow JR, Zhou QY, Grandy DK. The diversity of the dopamine receptors. Nida Research Monograph. 126: 23-33. PMID 1491715  0.96
1992 Eubanks JH, Djabali M, Selleri L, Grandy DK, Civelli O, McElligott DL, Evans GA. Structure and linkage of the D2 dopamine receptor and neural cell adhesion molecule genes on human chromosome 11q23. Genomics. 14: 1010-8. PMID 1478642 DOI: 10.1016/S0888-7543(05)80124-7  0.96
1992 Meador-Woodruff JH, Mansour A, Grandy DK, Damask SP, Civelli O, Watson SJ. Distribution of D5 dopamine receptor mRNA in rat brain. Neuroscience Letters. 145: 209-12. PMID 1465219 DOI: 10.1016/0304-3940(92)90024-2  0.96
1992 Grandy DK, Allen LJ, Zhang Y, Magenis RE, Civelli O. Chromosomal localization of three human D5 dopamine receptor genes. Genomics. 13: 968-73. PMID 1387108 DOI: 10.1016/0888-7543(92)90009-H  0.96
1992 Zhao B, Grandy DK, Hagerup JM, Magenis RE, Smith L, Chauhan BC, Henner WD. The human gene for apurinic/apyrimidinic endonuclease (HAP1): sequence and localization to chromosome 14 band q12. Nucleic Acids Research. 20: 4097-8. PMID 1380694  0.96
1992 Grandy DK, Leduc R, Makam H, Flanagan T, Diliberto EJ, Civelli O, Viveros OH. Nucleotide and deduced amino acid sequence of bovine adrenal medulla chromogranin B (secretogranin I). Cellular and Molecular Neurobiology. 12: 185-92. PMID 1350945 DOI: 10.1007/BF00713372  0.96
1992 Nöthen MM, Erdmann J, Körner J, Lanczik M, Fritze J, Fimmers R, Grandy DK, O'Dowd B, Propping P. Lack of association between dopamine D1 and D2 receptor genes and bipolar affective disorder American Journal of Psychiatry. 149: 199-201. PMID 1346486  0.96
1992 Liu YF, Civelli O, Grandy DK, Albert PR. Differential sensitivity of the short and long human dopamine D2 receptor subtypes to protein kinase C. Journal of Neurochemistry. 59: 2311-7. PMID 1331329  0.96
1991 Moises HW, Gelernter J, Giuffra LA, Zarcone V, Wetterberg L, Civelli O, Kidd KK, Cavalli-Sforza LL, Grandy DK, Kennedy JL. No linkage between D2 dopamine receptor gene region and schizophrenia. Archives of General Psychiatry. 48: 643-7. PMID 2069495 DOI: 10.1001/archpsyc.1991.01810310061011  0.96
1991 Sarkar G, Kapelner S, Grandy DK, Marchionni M, Civelli O, Sobell J, Heston L, Sommer SS. Direct sequencing of the dopamine D2 receptor (DRD2) in schizophrenics reveals three polymorphisms but no structural change in the receptor. Genomics. 11: 8-14. PMID 1837284 DOI: 10.1016/0888-7543(91)90096-W  0.96
1991 Grandy DK, Zhang YA, Bouvier C, Zhou QY, Johnson RA, Allen L, Buck K, Bunzow JR, Salon J, Civelli O. Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes. Proceedings of the National Academy of Sciences of the United States of America. 88: 9175-9. PMID 1833775  0.96
1991 Civelli O, Bunzow JR, Grandy DK, Zhou QY, Van Tol HH. Molecular biology of the dopamine receptors. European Journal of Pharmacology. 207: 277-86. PMID 1783000 DOI: 10.1016/0922-4106(91)90001-X  0.96
1991 Hauge XY, Grandy DK, Eubanks JH, Evans GA, Civelli O, Litt M. Detection and characterization of additional DNA polymorphisms in the dopamine D2 receptor gene. Genomics. 10: 527-30. PMID 1679742 DOI: 10.1016/0888-7543(91)90431-D  0.96
1990 Devor EJ, Grandy DK, Civelli O, Litt M, Burgess AK, Isenberg KE, van de Wetering BJ, Oostra B. Genetic linkage is excluded for the D2-dopamine receptor lambda HD2G1 and flanking loci on chromosome 11q22-q23 in Tourette syndrome. Human Heredity. 40: 105-8. PMID 2335364 DOI: 10.1159/000153914  0.96
1990 Zhou QY, Grandy DK, Thambi L, Kushner JA, Van Tol HH, Cone R, Pribnow D, Salon J, Bunzow JR, Civelli O. Cloning and expression of human and rat D1 dopamine receptors. Nature. 347: 76-80. PMID 2168520 DOI: 10.1038/347076a0  0.96
1990 Grandy DK, Hanneman E, Bunzow J, Shih M, Machida CA, Bidlack JM, Civelli O. Purification, cloning, and tissue distribution of a 23-kDa rat protein isolated by morphine affinity chromatography. Molecular Endocrinology (Baltimore, Md.). 4: 1370-6. PMID 1978248 DOI: 10.1210/mend-4-9-1370  0.96
1989 Grandy DK, Litt M, Allen L, Bunzow JR, Marchionni M, Makam H, Reed L, Magenis RE, Civelli O. The human dopamine D2 receptor gene is located on chromosome 11 at q22-q23 and identifies a TaqI RFLP. American Journal of Human Genetics. 45: 778-85. PMID 2573278  0.96
1989 Grandy DK, Marchionni MA, Makam H, Stofko RE, Alfano M, Frothingham L, Fischer JB, Burke-Howie KJ, Bunzow JR, Server AC. Cloning of the cDNA and gene for a human D2 dopamine receptor. Proceedings of the National Academy of Sciences of the United States of America. 86: 9762-6. PMID 2532362 DOI: 10.1073/pnas.86.24.9762  0.96
1988 Bunzow JR, Van Tol HH, Grandy DK, Albert P, Salon J, Christie M, Machida CA, Neve KA, Civelli O. Cloning and expression of a rat D2 dopamine receptor cDNA. Nature. 336: 783-7. PMID 2974511 DOI: 10.1038/336783a0  0.96
1987 Grandy DK, Dodgson JB. Structure and organization of the chicken H2B histone gene family Nucleic Acids Research. 15: 1063-1080. PMID 3822819 DOI: 10.1093/nar/15.3.1063  0.96
1982 Grandy DK, Engel JD, Dodgson JB. Complete nucleotide sequence of a chicken H2b histone gene Journal of Biological Chemistry. 257: 8577-8580. PMID 7096326  0.96
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