Dirk Hockemeyer - Publications

Molecular and Cell Biology University of California, Berkeley, Berkeley, CA 
Telomere biology of human stem cells

43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Schmutz I, Mensenkamp AR, Takai KK, Haadsma M, Spruijt L, de Voer RM, Choo SS, Lorbeer FK, van Grinsven EJ, Hockemeyer D, Jongmans MC, de Lange T. is a haploinsufficient tumor suppressor that limits telomere length. Elife. 9. PMID 33258446 DOI: 10.7554/eLife.61235  1
2020 Boyle JM, Hennick KM, Regalado SG, Vogan JM, Zhang X, Collins K, Hockemeyer D. Telomere length set point regulation in human pluripotent stem cells critically depends on the shelterin protein TPP1. Molecular Biology of the Cell. mbcE19080447. PMID 32903138 DOI: 10.1091/Mbc.E19-08-0447  1
2018 Schöneberg J, Dambournet D, Liu TL, Forster R, Hockemeyer D, Betzig E, Drubin DG. 4D cell biology: big data image analytics and lattice light-sheet imaging reveal dynamics of clathrin-mediated endocytosis in stem cell derived intestinal organoids. Molecular Biology of the Cell. mbcE18060375. PMID 30188768 DOI: 10.1016/J.Bpj.2018.11.928  1
2018 Blair JD, Hockemeyer D, Bateup HS. Genetically engineered human cortical spheroid models of tuberous sclerosis. Nature Medicine. PMID 30127391 DOI: 10.1038/S41591-018-0139-Y  1
2018 Liu TL, Upadhyayula S, Milkie DE, Singh V, Wang K, Swinburne IA, Mosaliganti KR, Collins ZM, Hiscock TW, Shea J, Kohrman AQ, Medwig TN, Dambournet D, Forster R, Cunniff B, ... ... Hockemeyer D, et al. Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms. Science (New York, N.Y.). 360. PMID 29674564 DOI: 10.1126/Science.Aaq1392  1
2017 Blair JD, Hockemeyer D, Doudna JA, Bateup HS, Floor SN. Widespread Translational Remodeling during Human Neuronal Differentiation. Cell Reports. 21: 2005-2016. PMID 29141229 DOI: 10.1016/J.Celrep.2017.10.095  1
2017 Chiba K, Lorbeer FK, Shain AH, McSwiggen DT, Schruf E, Oh A, Ryu J, Darzacq X, Bastian BC, Hockemeyer D. Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism. Science (New York, N.Y.). PMID 28818973 DOI: 10.1126/Science.Aao0535  1
2016 Chiba K, Vogan JM, Wu RA, Gill MS, Zhang X, Collins K, Hockemeyer D. Endogenous TERT N-terminal tagging affects human telomerase function at telomeres in vivo. Molecular and Cellular Biology. PMID 27872149 DOI: 10.1128/Mcb.00541-16  1
2016 Vogan JM, Zhang X, Youmans DT, Regalado SG, Johnson JZ, Hockemeyer D, Collins K. Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies. Elife. 5. PMID 27525486 DOI: 10.7554/Elife.18221  1
2016 Hockemeyer D, Jaenisch R. Induced Pluripotent Stem Cells Meet Genome Editing. Cell Stem Cell. 18: 573-86. PMID 27152442 DOI: 10.1016/J.Stem.2016.04.013  1
2016 Blair JD, Bateup HS, Hockemeyer DF. Establishment of Genome-edited Human Pluripotent Stem Cell Lines: From Targeting to Isolation. Journal of Visualized Experiments : Jove. PMID 26863600 DOI: 10.3791/53583  1
2015 Hockemeyer D, Collins K. Control of telomerase action at human telomeres. Nature Structural & Molecular Biology. 22: 848-52. PMID 26581518 DOI: 10.1038/Nsmb.3083  1
2015 Johnson JZ, Hockemeyer D. Human stem cell-based disease modeling: prospects and challenges. Current Opinion in Cell Biology. 37: 84-90. PMID 26546888 DOI: 10.1016/J.Ceb.2015.10.007  1
2015 Chiba K, Johnson JZ, Vogan JM, Wagner T, Boyle JM, Hockemeyer D. Cancer-associated TERT promoter mutations abrogate telomerase silencing. Elife. 4. PMID 26194807 DOI: 10.7554/Elife.07918  1
2015 Chiba K, Hockemeyer D. Genome editing in human pluripotent stem cells using site-specific nucleases. Methods in Molecular Biology (Clifton, N.J.). 1239: 267-80. PMID 25408412 DOI: 10.1007/978-1-4939-1862-1_15  1
2014 Kabir S, Hockemeyer D, de Lange T. TALEN gene knockouts reveal no requirement for the conserved human shelterin protein Rap1 in telomere protection and length regulation. Cell Reports. 9: 1273-80. PMID 25453752 DOI: 10.1016/J.Celrep.2014.10.014  1
2014 Sexton AN, Regalado SG, Lai CS, Cost GJ, O'Neil CM, Urnov FD, Gregory PD, Jaenisch R, Collins K, Hockemeyer D. Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation. Genes & Development. 28: 1885-99. PMID 25128433 DOI: 10.1101/Gad.246819.114  1
2014 Forster R, Chiba K, Schaeffer L, Regalado SG, Lai CS, Gao Q, Kiani S, Farin HF, Clevers H, Cost GJ, Chan A, Rebar EJ, Urnov FD, Gregory PD, Pachter L, ... ... Hockemeyer D, et al. Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells. Stem Cell Reports. 2: 838-52. PMID 24936470 DOI: 10.1016/J.Stemcr.2014.05.001  1
2014 Forster R, Hockemeyer D. Genome editing 101: let's go digital. Nature Methods. 11: 248-9. PMID 24577275 DOI: 10.1038/Nmeth.2859  1
2013 Li Y, Wang H, Muffat J, Cheng AW, Orlando DA, Lovén J, Kwok SM, Feldman DA, Bateup HS, Gao Q, Hockemeyer D, Mitalipova M, Lewis CA, Vander Heiden MG, Sur M, et al. Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons. Cell Stem Cell. 13: 446-58. PMID 24094325 DOI: 10.1016/J.Stem.2013.09.001  1
2011 Gao Q, Steine EJ, Barrasa MI, Hockemeyer D, Pawlak M, Fu D, Reddy S, Bell GW, Jaenisch R. Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression. Proceedings of the National Academy of Sciences of the United States of America. 108: 18061-6. PMID 22011581 DOI: 10.1073/Pnas.1114946108  1
2011 Major T, Menon J, Auyeung G, Soldner F, Hockemeyer D, Jaenisch R, Tabar V. Transgene excision has no impact on in vivo integration of human iPS derived neural precursors. Plos One. 6: e24687. PMID 21961042 DOI: 10.1371/Journal.Pone.0024687  1
2011 Soldner F, Laganière J, Cheng AW, Hockemeyer D, Gao Q, Alagappan R, Khurana V, Golbe LI, Myers RH, Lindquist S, Zhang L, Guschin D, Fong LK, Vu BJ, Meng X, et al. Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell. 146: 318-31. PMID 21757228 DOI: 10.1016/J.Cell.2011.06.019  1
2011 Hockemeyer D, Wang H, Kiani S, Lai CS, Gao Q, Cassady JP, Cost GJ, Zhang L, Santiago Y, Miller JC, Zeitler B, Cherone JM, Meng X, Hinkley SJ, Rebar EJ, et al. Genetic engineering of human pluripotent cells using TALE nucleases. Nature Biotechnology. 29: 731-4. PMID 21738127 DOI: 10.1038/Nbt.1927  1
2010 Hockemeyer D, Jaenisch R. Gene targeting in human pluripotent cells. Cold Spring Harbor Symposia On Quantitative Biology. 75: 201-9. PMID 21209393 DOI: 10.1101/Sqb.2010.75.021  1
2010 Hargus G, Cooper O, Deleidi M, Levy A, Lee K, Marlow E, Yow A, Soldner F, Hockemeyer D, Hallett PJ, Osborn T, Jaenisch R, Isacson O. Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats. Proceedings of the National Academy of Sciences of the United States of America. 107: 15921-6. PMID 20798034 DOI: 10.1073/Pnas.1010209107  1
2010 Guenther MG, Frampton GM, Soldner F, Hockemeyer D, Mitalipova M, Jaenisch R, Young RA. Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. Cell Stem Cell. 7: 249-57. PMID 20682450 DOI: 10.1016/J.Stem.2010.06.015  1
2010 DeKelver RC, Choi VM, Moehle EA, Paschon DE, Hockemeyer D, Meijsing SH, Sancak Y, Cui X, Steine EJ, Miller JC, Tam P, Bartsevich VV, Meng X, Rupniewski I, Gopalan SM, et al. Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Research. 20: 1133-42. PMID 20508142 DOI: 10.1101/Gr.106773.110  1
2009 Hockemeyer D, Soldner F, Beard C, Gao Q, Mitalipova M, DeKelver RC, Katibah GE, Amora R, Boydston EA, Zeitler B, Meng X, Miller JC, Zhang L, Rebar EJ, Gregory PD, et al. Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nature Biotechnology. 27: 851-7. PMID 19680244 DOI: 10.1038/Nbt.1562  1
2009 Sfeir A, Kosiyatrakul ST, Hockemeyer D, MacRae SL, Karlseder J, Schildkraut CL, de Lange T. Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell. 138: 90-103. PMID 19596237 DOI: 10.1016/J.Cell.2009.06.021  1
2009 Soldner F, Hockemeyer D, Beard C, Gao Q, Bell GW, Cook EG, Hargus G, Blak A, Cooper O, Mitalipova M, Isacson O, Jaenisch R. Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell. 136: 964-77. PMID 19269371 DOI: 10.1016/J.Cell.2009.02.013  1
2009 Palm W, Hockemeyer D, Kibe T, de Lange T. Functional dissection of human and mouse POT1 proteins. Molecular and Cellular Biology. 29: 471-82. PMID 18955498 DOI: 10.1128/Mcb.01352-08  1
2009 Soldner F, Hockemeyer D, Beard C, Gao Q, Bell GW, Cook EG, Hargus G, Blak A, Cooper O, Mitalipova M, Isacson O, Jaenisch R. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors (DOI:10.1016/j.cell.2009.02.013) Cell. 137: 1356. DOI: 10.1016/j.cell.2009.06.017  1
2009 Hockemeyer D, Soldner F, Jaenisch R. Direct Reprogramming of Somatic Cells to a Pluripotent State Essentials of Stem Cell Biology. 29-31. DOI: 10.1016/B978-0-12-374729-7.00004-4  1
2008 Hockemeyer D, Soldner F, Cook EG, Gao Q, Mitalipova M, Jaenisch R. A drug-inducible system for direct reprogramming of human somatic cells to pluripotency. Cell Stem Cell. 3: 346-53. PMID 18786421 DOI: 10.1016/J.Stem.2008.08.014  1
2008 Hockemeyer D, Palm W, Wang RC, Couto SS, de Lange T. Engineered telomere degradation models dyskeratosis congenita. Genes & Development. 22: 1773-85. PMID 18550783 DOI: 10.1101/Gad.1679208  1
2007 Hockemeyer D, Palm W, Else T, Daniels JP, Takai KK, Ye JZ, Keegan CE, de Lange T, Hammer GD. Telomere protection by mammalian Pot1 requires interaction with Tpp1. Nature Structural & Molecular Biology. 14: 754-61. PMID 17632522 DOI: 10.1038/Nsmb1270  1
2006 Hockemeyer D, Daniels JP, Takai H, de Lange T. Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres. Cell. 126: 63-77. PMID 16839877 DOI: 10.1016/J.Cell.2006.04.044  1
2005 Hockemeyer D, Sfeir AJ, Shay JW, Wright WE, de Lange T. POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. The Embo Journal. 24: 2667-78. PMID 15973431 DOI: 10.1038/Sj.Emboj.7600733  1
2004 Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT, de Lange T. POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes & Development. 18: 1649-54. PMID 15231715 DOI: 10.1101/Gad.1215404  1
2004 Schratt G, Philippar U, Hockemeyer D, Schwarz H, Alberti S, Nordheim A. SRF regulates Bcl-2 expression and promotes cell survival during murine embryonic development. The Embo Journal. 23: 1834-44. PMID 15057274 DOI: 10.1038/Sj.Emboj.7600188  1
2004 Wang Z, Wang DZ, Hockemeyer D, McAnally J, Nordheim A, Olson EN. Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. Nature. 428: 185-9. PMID 15014501 DOI: 10.1038/Nature02382  1
2002 Wang DZ, Li S, Hockemeyer D, Sutherland L, Wang Z, Schratt G, Richardson JA, Nordheim A, Olson EN. Potentiation of serum response factor activity by a family of myocardin-related transcription factors. Proceedings of the National Academy of Sciences of the United States of America. 99: 14855-60. PMID 12397177 DOI: 10.1073/Pnas.222561499  1
Show low-probability matches.