Dirk Hockemeyer - Publications

Molecular and Cell Biology University of California, Berkeley, Berkeley, CA, United States 
Telomere biology of human stem cells

55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Li H, Bartke R, Zhao L, Verma Y, Horacek A, Rechav Ben-Natan A, Pangilinan GR, Krishnappa N, Nielsen R, Hockemeyer D. Functional annotation of variants of the BRCA2 gene via locally haploid human pluripotent stem cells. Nature Biomedical Engineering. PMID 37488236 DOI: 10.1038/s41551-023-01065-7  0.329
2023 Turkalo TK, Maffia A, Schabort JJ, Regalado SG, Bhakta M, Blanchette M, Spierings DCJ, Lansdorp PM, Hockemeyer D. A non-genetic switch triggers alternative telomere lengthening and cellular immortalization in ATRX deficient cells. Nature Communications. 14: 939. PMID 36805596 DOI: 10.1038/s41467-023-36294-6  0.382
2022 Li H, Busquets O, Verma Y, Syed KM, Kutnowski N, Pangilinan GR, Gilbert LA, Bateup HS, Rio DC, Hockemeyer D, Soldner F. Highly efficient generation of isogenic pluripotent stem cell models using prime editing. Elife. 11. PMID 36069759 DOI: 10.7554/eLife.79208  0.303
2022 Choo S, Lorbeer FK, Regalado SG, Short SB, Wu SS, Rieser G, Bertuch AA, Hockemeyer D. Editing TINF2 as a potential therapeutic approach to restore telomere length in dyskeratosis congenita. Blood. PMID 35421215 DOI: 10.1182/blood.2021013750  0.409
2020 Schmutz I, Mensenkamp AR, Takai KK, Haadsma M, Spruijt L, de Voer RM, Choo SS, Lorbeer FK, van Grinsven EJ, Hockemeyer D, Jongmans MC, de Lange T. is a haploinsufficient tumor suppressor that limits telomere length. Elife. 9. PMID 33258446 DOI: 10.7554/eLife.61235  0.525
2020 Boyle JM, Hennick KM, Regalado SG, Vogan JM, Zhang X, Collins K, Hockemeyer D. Telomere length set point regulation in human pluripotent stem cells critically depends on the shelterin protein TPP1. Molecular Biology of the Cell. mbcE19080447. PMID 32903138 DOI: 10.1091/Mbc.E19-08-0447  0.519
2020 Shin JJ, Schröder MS, Caiado F, Wyman SK, Bray NL, Bordi M, Dewitt MA, Vu JT, Kim WT, Hockemeyer D, Manz MG, Corn JE. Controlled Cycling and Quiescence Enables Efficient HDR in Engraftment-Enriched Adult Hematopoietic Stem and Progenitor Cells. Cell Reports. 32: 108093. PMID 32877675 DOI: 10.1016/J.Celrep.2020.108093  0.435
2020 Lorbeer FK, Hockemeyer D. TERT promoter mutations and telomeres during tumorigenesis. Current Opinion in Genetics & Development. 60: 56-62. PMID 32163830 DOI: 10.1016/J.Gde.2020.02.001  0.39
2019 Simic MS, Moehle EA, Schinzel RT, Lorbeer FK, Halloran JJ, Heydari K, Sanchez M, Jullié D, Hockemeyer D, Dillin A. Transient activation of the UPR is an essential step in the acquisition of pluripotency during reprogramming. Science Advances. 5: eaaw0025. PMID 30989118 DOI: 10.1126/Sciadv.Aaw0025  0.4
2019 Hockemeyer D. Decision letter: Persistent epigenetic memory impedes rescue of the telomeric phenotype in human ICF iPSCs following DNMT3B correction Elife. DOI: 10.7554/Elife.47859.Sa1  0.307
2018 Schöneberg J, Dambournet D, Liu TL, Forster R, Hockemeyer D, Betzig E, Drubin DG. 4D cell biology: big data image analytics and lattice light-sheet imaging reveal dynamics of clathrin-mediated endocytosis in stem cell derived intestinal organoids. Molecular Biology of the Cell. mbcE18060375. PMID 30188768 DOI: 10.1016/J.Bpj.2018.11.928  0.306
2018 Blair JD, Hockemeyer D, Bateup HS. Genetically engineered human cortical spheroid models of tuberous sclerosis. Nature Medicine. PMID 30127391 DOI: 10.1038/S41591-018-0139-Y  0.427
2018 Dambournet D, Sochacki KA, Cheng AT, Akamatsu M, Taraska JW, Hockemeyer D, Drubin DG. Genome-edited human stem cells expressing fluorescently labeled endocytic markers allow quantitative analysis of clathrin-mediated endocytosis during differentiation. The Journal of Cell Biology. PMID 29980624 DOI: 10.1083/Jcb.201710084  0.434
2018 Liu TL, Upadhyayula S, Milkie DE, Singh V, Wang K, Swinburne IA, Mosaliganti KR, Collins ZM, Hiscock TW, Shea J, Kohrman AQ, Medwig TN, Dambournet D, Forster R, Cunniff B, ... ... Hockemeyer D, et al. Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms. Science (New York, N.Y.). 360. PMID 29674564 DOI: 10.1126/Science.Aaq1392  0.33
2017 Blair JD, Hockemeyer D, Doudna JA, Bateup HS, Floor SN. Widespread Translational Remodeling during Human Neuronal Differentiation. Cell Reports. 21: 2005-2016. PMID 29141229 DOI: 10.1016/J.Celrep.2017.10.095  0.404
2017 Chiba K, Lorbeer FK, Shain AH, McSwiggen DT, Schruf E, Oh A, Ryu J, Darzacq X, Bastian BC, Hockemeyer D. Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism. Science (New York, N.Y.). PMID 28818973 DOI: 10.1126/Science.Aao0535  0.405
2017 Rodrigues GMC, Gaj T, Adil MM, Wahba J, Rao AT, Lorbeer FK, Kulkarni RU, Diogo MM, Cabral JMS, Miller EW, Hockemeyer D, Schaffer DV. Defined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3D Culture System. Stem Cell Reports. PMID 28552605 DOI: 10.1016/J.Stemcr.2017.04.027  0.419
2016 Chiba K, Vogan JM, Wu RA, Gill MS, Zhang X, Collins K, Hockemeyer D. Endogenous TERT N-terminal tagging affects human telomerase function at telomeres in vivo. Molecular and Cellular Biology. PMID 27872149 DOI: 10.1128/Mcb.00541-16  0.504
2016 Vogan JM, Zhang X, Youmans DT, Regalado SG, Johnson JZ, Hockemeyer D, Collins K. Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies. Elife. 5. PMID 27525486 DOI: 10.7554/Elife.18221  0.424
2016 Hockemeyer D, Jaenisch R. Induced Pluripotent Stem Cells Meet Genome Editing. Cell Stem Cell. 18: 573-86. PMID 27152442 DOI: 10.1016/J.Stem.2016.04.013  0.548
2016 Blair JD, Bateup HS, Hockemeyer DF. Establishment of Genome-edited Human Pluripotent Stem Cell Lines: From Targeting to Isolation. Journal of Visualized Experiments : Jove. PMID 26863600 DOI: 10.3791/53583  0.366
2016 Vogan JM, Zhang X, Youmans DT, Regalado SG, Johnson JZ, Hockemeyer D, Collins K. Author response: Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies Elife. DOI: 10.7554/Elife.18221.018  0.339
2015 Hockemeyer D, Collins K. Control of telomerase action at human telomeres. Nature Structural & Molecular Biology. 22: 848-52. PMID 26581518 DOI: 10.1038/Nsmb.3083  0.43
2015 Johnson JZ, Hockemeyer D. Human stem cell-based disease modeling: prospects and challenges. Current Opinion in Cell Biology. 37: 84-90. PMID 26546888 DOI: 10.1016/J.Ceb.2015.10.007  0.437
2015 Chiba K, Johnson JZ, Vogan JM, Wagner T, Boyle JM, Hockemeyer D. Cancer-associated TERT promoter mutations abrogate telomerase silencing. Elife. 4. PMID 26194807 DOI: 10.7554/Elife.07918  0.421
2015 Chiba K, Hockemeyer D. Genome editing in human pluripotent stem cells using site-specific nucleases. Methods in Molecular Biology (Clifton, N.J.). 1239: 267-80. PMID 25408412 DOI: 10.1007/978-1-4939-1862-1_15  0.407
2014 Kabir S, Hockemeyer D, de Lange T. TALEN gene knockouts reveal no requirement for the conserved human shelterin protein Rap1 in telomere protection and length regulation. Cell Reports. 9: 1273-80. PMID 25453752 DOI: 10.1016/J.Celrep.2014.10.014  0.639
2014 Sexton AN, Regalado SG, Lai CS, Cost GJ, O'Neil CM, Urnov FD, Gregory PD, Jaenisch R, Collins K, Hockemeyer D. Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation. Genes & Development. 28: 1885-99. PMID 25128433 DOI: 10.1101/Gad.246819.114  0.627
2014 Forster R, Chiba K, Schaeffer L, Regalado SG, Lai CS, Gao Q, Kiani S, Farin HF, Clevers H, Cost GJ, Chan A, Rebar EJ, Urnov FD, Gregory PD, Pachter L, ... ... Hockemeyer D, et al. Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells. Stem Cell Reports. 2: 838-52. PMID 24936470 DOI: 10.1016/J.Stemcr.2014.05.001  0.571
2014 Forster R, Hockemeyer D. Genome editing 101: let's go digital. Nature Methods. 11: 248-9. PMID 24577275 DOI: 10.1038/Nmeth.2859  0.412
2014 Forster R, Chiba K, Schaeffer L, Regalado S, Lai C, Gao Q, Kiani S, Farin H, Clevers H, Cost G, Chan A, Rebar E, Urnov F, Gregory P, Pachter L, ... ... Hockemeyer D, et al. Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells Stem Cell Reports. 3: 215. DOI: 10.1016/J.Stemcr.2014.06.014  0.559
2013 Li Y, Wang H, Muffat J, Cheng AW, Orlando DA, Lovén J, Kwok SM, Feldman DA, Bateup HS, Gao Q, Hockemeyer D, Mitalipova M, Lewis CA, Vander Heiden MG, Sur M, et al. Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons. Cell Stem Cell. 13: 446-58. PMID 24094325 DOI: 10.1016/J.Stem.2013.09.001  0.721
2011 Gao Q, Steine EJ, Barrasa MI, Hockemeyer D, Pawlak M, Fu D, Reddy S, Bell GW, Jaenisch R. Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression. Proceedings of the National Academy of Sciences of the United States of America. 108: 18061-6. PMID 22011581 DOI: 10.1073/Pnas.1114946108  0.456
2011 Major T, Menon J, Auyeung G, Soldner F, Hockemeyer D, Jaenisch R, Tabar V. Transgene excision has no impact on in vivo integration of human iPS derived neural precursors. Plos One. 6: e24687. PMID 21961042 DOI: 10.1371/Journal.Pone.0024687  0.549
2011 Soldner F, Laganière J, Cheng AW, Hockemeyer D, Gao Q, Alagappan R, Khurana V, Golbe LI, Myers RH, Lindquist S, Zhang L, Guschin D, Fong LK, Vu BJ, Meng X, et al. Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell. 146: 318-31. PMID 21757228 DOI: 10.1016/J.Cell.2011.06.019  0.682
2011 Hockemeyer D, Wang H, Kiani S, Lai CS, Gao Q, Cassady JP, Cost GJ, Zhang L, Santiago Y, Miller JC, Zeitler B, Cherone JM, Meng X, Hinkley SJ, Rebar EJ, et al. Genetic engineering of human pluripotent cells using TALE nucleases. Nature Biotechnology. 29: 731-4. PMID 21738127 DOI: 10.1038/Nbt.1927  0.59
2010 Hockemeyer D, Jaenisch R. Gene targeting in human pluripotent cells. Cold Spring Harbor Symposia On Quantitative Biology. 75: 201-9. PMID 21209393 DOI: 10.1101/Sqb.2010.75.021  0.602
2010 Hargus G, Cooper O, Deleidi M, Levy A, Lee K, Marlow E, Yow A, Soldner F, Hockemeyer D, Hallett PJ, Osborn T, Jaenisch R, Isacson O. Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats. Proceedings of the National Academy of Sciences of the United States of America. 107: 15921-6. PMID 20798034 DOI: 10.1073/Pnas.1010209107  0.513
2010 Guenther MG, Frampton GM, Soldner F, Hockemeyer D, Mitalipova M, Jaenisch R, Young RA. Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. Cell Stem Cell. 7: 249-57. PMID 20682450 DOI: 10.1016/J.Stem.2010.06.015  0.551
2010 DeKelver RC, Choi VM, Moehle EA, Paschon DE, Hockemeyer D, Meijsing SH, Sancak Y, Cui X, Steine EJ, Miller JC, Tam P, Bartsevich VV, Meng X, Rupniewski I, Gopalan SM, et al. Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Research. 20: 1133-42. PMID 20508142 DOI: 10.1101/Gr.106773.110  0.564
2009 Hockemeyer D, Soldner F, Beard C, Gao Q, Mitalipova M, DeKelver RC, Katibah GE, Amora R, Boydston EA, Zeitler B, Meng X, Miller JC, Zhang L, Rebar EJ, Gregory PD, et al. Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nature Biotechnology. 27: 851-7. PMID 19680244 DOI: 10.1038/Nbt.1562  0.574
2009 Sfeir A, Kosiyatrakul ST, Hockemeyer D, MacRae SL, Karlseder J, Schildkraut CL, de Lange T. Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication. Cell. 138: 90-103. PMID 19596237 DOI: 10.1016/J.Cell.2009.06.021  0.703
2009 Soldner F, Hockemeyer D, Beard C, Gao Q, Bell GW, Cook EG, Hargus G, Blak A, Cooper O, Mitalipova M, Isacson O, Jaenisch R. Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell. 136: 964-77. PMID 19269371 DOI: 10.1016/J.Cell.2009.02.013  0.564
2009 Palm W, Hockemeyer D, Kibe T, de Lange T. Functional dissection of human and mouse POT1 proteins. Molecular and Cellular Biology. 29: 471-82. PMID 18955498 DOI: 10.1128/Mcb.01352-08  0.597
2009 Hockemeyer D, Palm W, Else T, Daniels J, Takai KK, Ye JZ, Keegan CE, de Lange T, Hammer GD. Erratum: Corrigendum: Telomere protection by mammalian Pot1 requires interaction with Tpp1 Nature Structural & Molecular Biology. 16: 572-572. DOI: 10.1038/Nsmb0509-572A  0.307
2009 Soldner F, Hockemeyer D, Beard C, Gao Q, Bell GW, Cook EG, Hargus G, Blak A, Cooper O, Mitalipova M, Isacson O, Jaenisch R. Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors (DOI:10.1016/j.cell.2009.02.013) Cell. 137: 1356. DOI: 10.1016/j.cell.2009.06.017  0.492
2009 Hockemeyer D, Soldner F, Jaenisch R. Direct Reprogramming of Somatic Cells to a Pluripotent State Essentials of Stem Cell Biology. 29-31. DOI: 10.1016/B978-0-12-374729-7.00004-4  0.45
2008 Hockemeyer D, Soldner F, Cook EG, Gao Q, Mitalipova M, Jaenisch R. A drug-inducible system for direct reprogramming of human somatic cells to pluripotency. Cell Stem Cell. 3: 346-53. PMID 18786421 DOI: 10.1016/J.Stem.2008.08.014  0.569
2008 Hockemeyer D, Palm W, Wang RC, Couto SS, de Lange T. Engineered telomere degradation models dyskeratosis congenita. Genes & Development. 22: 1773-85. PMID 18550783 DOI: 10.1101/Gad.1679208  0.553
2007 Hockemeyer D, Palm W, Else T, Daniels JP, Takai KK, Ye JZ, Keegan CE, de Lange T, Hammer GD. Telomere protection by mammalian Pot1 requires interaction with Tpp1. Nature Structural & Molecular Biology. 14: 754-61. PMID 17632522 DOI: 10.1038/Nsmb1270  0.625
2006 Hockemeyer D, Daniels JP, Takai H, de Lange T. Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres. Cell. 126: 63-77. PMID 16839877 DOI: 10.1016/J.Cell.2006.04.044  0.632
2005 Hockemeyer D, Sfeir AJ, Shay JW, Wright WE, de Lange T. POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. The Embo Journal. 24: 2667-78. PMID 15973431 DOI: 10.1038/Sj.Emboj.7600733  0.618
2004 Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT, de Lange T. POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes & Development. 18: 1649-54. PMID 15231715 DOI: 10.1101/Gad.1215404  0.585
2004 Schratt G, Philippar U, Hockemeyer D, Schwarz H, Alberti S, Nordheim A. SRF regulates Bcl-2 expression and promotes cell survival during murine embryonic development. The Embo Journal. 23: 1834-44. PMID 15057274 DOI: 10.1038/Sj.Emboj.7600188  0.389
2002 Wang DZ, Li S, Hockemeyer D, Sutherland L, Wang Z, Schratt G, Richardson JA, Nordheim A, Olson EN. Potentiation of serum response factor activity by a family of myocardin-related transcription factors. Proceedings of the National Academy of Sciences of the United States of America. 99: 14855-60. PMID 12397177 DOI: 10.1073/Pnas.222561499  0.338
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