Wenyi Wei, Ph.D. - Publications

Affiliations: 
2002 Brown University, Providence, RI 

96 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Zhou W, Xu J, Tan M, Li H, Li H, Wei W, Sun Y. UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F. Molecular Cell. 70: 1008-1024.e6. PMID 29932898 DOI: 10.1016/j.molcel.2018.06.002  0.6
2018 Zhang J, Guo J, Qin X, Wang B, Zhang L, Wang Y, Gan W, Pandofi PP, Chen W, Wei W. The p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth. Science Signaling. 11. PMID 29588411 DOI: 10.1126/scisignal.aao1052  0.52
2017 Wang X, Cao W, Zhang J, Yan M, Xu Q, Wu X, Wan L, Zhang Z, Zhang C, Qin X, Xiao M, Ye D, Liu Y, Han Z, Wang S, ... ... Wei W, et al. A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination. The Embo Journal. PMID 28320739 DOI: 10.15252/embj.201694058  0.52
2016 Cheng J, Zhang T, Ji H, Tao K, Guo J, Wei W. Functional characterization of AMP-activated protein kinase signaling in tumorigenesis. Biochimica Et Biophysica Acta. PMID 27681874 DOI: 10.1016/j.bbcan.2016.09.006  0.92
2016 Zurlo G, Guo J, Takada M, Wei W, Zhang Q. New Insights into Protein Hydroxylation and Its Important Role in Human Diseases. Biochimica Et Biophysica Acta. PMID 27663420 DOI: 10.1016/j.bbcan.2016.09.004  0.92
2016 Zhang J, Xu K, Liu P, Geng Y, Wang B, Gan W, Guo J, Wu F, Chin YR, Berrios C, Lien EC, Toker A, DeCaprio JA, Sicinski P, Wei W. Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt. Molecular Cell. PMID 27237051 DOI: 10.1016/j.molcel.2016.04.023  0.92
2016 Shao R, Liu J, Yan G, Zhang J, Han Y, Guo J, Xu Z, Yuan Z, Liu J, Malumbres M, Wan L, Wei W, Zou W. Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid. Cell Research. PMID 27126000 DOI: 10.1038/cr.2016.51  0.92
2016 Wang BL, Shi YX, Zhang SJ, Ma Y, Wang HX, Zhang LY, Wei W, Liu XH, Li YH, Li ZM, Li BJ. Syntheses, biological activities and SAR studies of novel carboxamide compounds containing piperazine and arylsulfonyl moieties. European Journal of Medicinal Chemistry. 117: 167-178. PMID 27092414 DOI: 10.1016/j.ejmech.2016.04.005  0.6
2016 Zheng N, Wang Z, Wei W. Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteins. The International Journal of Biochemistry & Cell Biology. PMID 26860958 DOI: 10.1016/j.biocel.2016.02.005  0.92
2016 Qin X, Yan M, Zhang J, Wang X, Shen Z, Lv Z, Li Z, Wei W, Chen W. TGFβ3-mediated induction of Periostin facilitates head and neck cancer growth and is associated with metastasis. Scientific Reports. 6: 20587. PMID 26857387 DOI: 10.1038/srep20587  0.92
2016 Zheng N, Wei W, Wang Z. Emerging roles of FGF signaling in hepatocellular carcinoma Translational Cancer Research. 5: 1-6. DOI: 10.3978/j.issn.2218-676X.2016.01.05  0.92
2015 Wang Z, Dai X, Zhong J, Inuzuka H, Wan L, Li X, Wang L, Ye X, Sun L, Gao D, Zou L, Wei W. SCF(β-TRCP) promotes cell growth by targeting PR-Set7/Set8 for degradation. Nature Communications. 6: 10185. PMID 26666832 DOI: 10.1038/ncomms10185  0.92
2015 Gan W, Dai X, Lunardi A, Li Z, Inuzuka H, Liu P, Varmeh S, Zhang J, Cheng L, Sun Y, Asara JM, Beck AH, Huang J, Pandolfi PP, Wei W. SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression. Molecular Cell. PMID 26344095 DOI: 10.1016/j.molcel.2015.07.026  0.92
2015 Cao J, Dai X, Wan L, Wang H, Zhang J, Goff PS, Sviderskaya EV, Xuan Z, Xu Z, Xu X, Hinds P, Flaherty KT, Faller DV, Goding CR, Wang Y, ... Wei W, et al. The E3 ligase APC/CCdh1 promotes ubiquitylation-mediated proteolysis of PAX3 to suppress melanocyte proliferation and melanoma growth. Science Signaling. 8: ra87. PMID 26329581 DOI: 10.1126/scisignal.aab1995  0.92
2015 Liu P, Gan W, Chin YR, Ogura K, Guo J, Zhang J, Wang B, Blenis J, Cantley LC, Toker A, Su B, Wei W. PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex. Cancer Discovery. 5: 1194-209. PMID 26293922 DOI: 10.1158/2159-8290.CD-15-0460  0.92
2015 Gan W, Liu P, Wei W. Akt promotes tumorigenesis in part through modulating genomic instability via phosphorylating XLF. Nucleus (Austin, Tex.). 6: 261-5. PMID 26225792 DOI: 10.1080/19491034.2015.1074365  0.92
2015 Gan W, Liu P, Wei W. Cell cycle status dictates effectiveness of rapamycin. Cell Cycle (Georgetown, Tex.). 1-2. PMID 26126171 DOI: 10.1080/15384101.2015.1060778  0.92
2015 Wang L, Zhang J, Wan L, Zhou X, Wang Z, Wei W. Targeting Cdc20 as a novel cancer therapeutic strategy. Pharmacology & Therapeutics. 151: 141-151. PMID 25850036 DOI: 10.1016/j.pharmthera.2015.04.002  0.92
2015 Liu P, Gan W, Guo C, Xie A, Gao D, Guo J, Zhang J, Willis N, Su A, Asara JM, Scully R, Wei W. Akt-mediated phosphorylation of XLF impairs non-homologous end-joining DNA repair. Molecular Cell. 57: 648-61. PMID 25661488 DOI: 10.1016/j.molcel.2015.01.005  0.92
2015 Su J, Yin X, Zhou X, Wei W, Wang Z. The functions of F-box proteins in regulating the epithelial to mesenchymal transition. Current Pharmaceutical Design. 21: 1311-7. PMID 25506894  0.92
2015 Liu J, Shaik S, Dai X, Wu Q, Zhou X, Wang Z, Wei W. Targeting the ubiquitin pathway for cancer treatment. Biochimica Et Biophysica Acta. 1855: 50-60. PMID 25481052 DOI: 10.1016/j.bbcan.2014.11.005  0.92
2014 Gasser JA, Inuzuka H, Lau AW, Wei W, Beroukhim R, Toker A. SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer. Molecular Cell. 56: 595-607. PMID 25458846 DOI: 10.1016/j.molcel.2014.09.023  0.92
2014 Xu K, Liu P, Wei W. mTOR signaling in tumorigenesis. Biochimica Et Biophysica Acta. 1846: 638-54. PMID 25450580 DOI: 10.1016/j.bbcan.2014.10.007  0.92
2014 Li N, Fassl A, Chick J, Inuzuka H, Li X, Mansour MR, Liu L, Wang H, King B, Shaik S, Gutierrez A, Ordureau A, Otto T, Kreslavsky T, Baitsch L, ... ... Wei W, et al. Cyclin C is a haploinsufficient tumour suppressor. Nature Cell Biology. 16: 1080-91. PMID 25344755 DOI: 10.1038/ncb3046  0.92
2014 Ye X, Wang L, Shang B, Wang Z, Wei W. NEDD4: a promising target for cancer therapy. Current Cancer Drug Targets. 14: 549-56. PMID 25088038 DOI: 10.2174/1568009614666140725092430  0.92
2014 Wu X, Fukushima H, North BJ, Nagaoka Y, Nagashima K, Deng F, Okabe K, Inuzuka H, Wei W. SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination. Oncotarget. 5: 4211-21. PMID 24961988  0.92
2014 Liu P, Wang Z, Wei W. Phosphorylation of Akt at the C-terminal tail triggers Akt activation. Cell Cycle (Georgetown, Tex.). 13: 2162-4. PMID 24933731 DOI: 10.4161/cc.29584  0.92
2014 Wang L, Ye X, Liu Y, Wei W, Wang Z. Aberrant regulation of FBW7 in cancer. Oncotarget. 5: 2000-15. PMID 24899581 DOI: 10.18632/oncotarget.1859  0.92
2014 Wan L, Tan M, Yang J, Inuzuka H, Dai X, Wu T, Liu J, Shaik S, Chen G, Deng J, Malumbres M, Letai A, Kirschner MW, Sun Y, Wei W. APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction. Developmental Cell. 29: 377-91. PMID 24871945 DOI: 10.1016/j.devcel.2014.04.022  0.92
2014 Papa A, Wan L, Bonora M, Salmena L, Song MS, Hobbs RM, Lunardi A, Webster K, Ng C, Newton RH, Knoblauch N, Guarnerio J, Ito K, Turka LA, Beck AH, ... ... Wei W, et al. Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function. Cell. 157: 595-610. PMID 24766807 DOI: 10.1016/j.cell.2014.03.027  0.92
2014 Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, ... ... Wei W, et al. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 508: 541-5. PMID 24670654 DOI: 10.1038/nature13079  0.92
2014 Wang Z, Liu P, Inuzuka H, Wei W. Roles of F-box proteins in cancer. Nature Reviews. Cancer. 14: 233-47. PMID 24658274 DOI: 10.1038/nrc3700  0.92
2014 Liu J, Wan L, Liu P, Inuzuka H, Liu J, Wang Z, Wei W. SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway. Oncotarget. 5: 1026-37. PMID 24657926  0.92
2014 Zhang J, Wan L, Dai X, Sun Y, Wei W. Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis. Biochimica Et Biophysica Acta. 1845: 277-93. PMID 24569229 DOI: 10.1016/j.bbcan.2014.02.001  0.92
2014 Liu P, Guo J, Gan W, Wei W. Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity. Protein & Cell. 5: 171-7. PMID 24481632 DOI: 10.1007/s13238-014-0021-8  0.92
2013 Zhong J, Shaik S, Wan L, Tron AE, Wang Z, Sun L, Inuzuka H, Wei W. SCF β-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration. Oncotarget. 4: 2339-53. PMID 24318128  0.92
2013 Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, ... ... Wei W, et al. Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nature Cell Biology. 15: 1340-50. PMID 24161930 DOI: 10.1038/ncb2860  0.92
2013 Cao J, Wan L, Hacker E, Dai X, Lenna S, Jimenez-Cervantes C, Wang Y, Leslie NR, Xu GX, Widlund HR, Ryu B, Alani RM, Dutton-Regester K, Goding CR, Hayward NK, ... Wei W, et al. MC1R is a potent regulator of PTEN after UV exposure in melanocytes. Molecular Cell. 51: 409-22. PMID 23973372 DOI: 10.1016/j.molcel.2013.08.010  0.92
2013 Fukushima H, Ogura K, Wan L, Lu Y, Li V, Gao D, Liu P, Lau AW, Wu T, Kirschner MW, Inuzuka H, Wei W. SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. Cell Reports. 4: 803-16. PMID 23972993 DOI: 10.1016/j.celrep.2013.07.031  0.92
2013 Lau AW, Inuzuka H, Fukushima H, Wan L, Liu P, Gao D, Sun Y, Wei W. Regulation of APC(Cdh1) E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7. Cell Research. 23: 947-61. PMID 23670162 DOI: 10.1038/cr.2013.67  0.92
2013 Zhou W, Wei W, Sun Y. Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases. Cell Research. 23: 599-619. PMID 23528706 DOI: 10.1038/cr.2013.44  0.92
2013 Xie CM, Wei W, Sun Y. Role of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases in skin cancer. Journal of Genetics and Genomics = Yi Chuan Xue Bao. 40: 97-106. PMID 23522382 DOI: 10.1016/j.jgg.2013.02.001  0.92
2013 Liu F, Cao J, Wu J, Sullivan K, Shen J, Ryu B, Xu Z, Wei W, Cui R. Stat3-targeted therapies overcome the acquired resistance to vemurafenib in melanomas. The Journal of Investigative Dermatology. 133: 2041-9. PMID 23344460 DOI: 10.1038/jid.2013.32  0.92
2013 Chen H, Ma H, Inuzuka H, Diao J, Lan F, Shi YG, Wei W, Shi Y. DNA damage regulates UHRF1 stability via the SCF(β-TrCP) E3 ligase. Molecular and Cellular Biology. 33: 1139-48. PMID 23297342 DOI: 10.1128/MCB.01191-12  0.92
2013 Wang Z, Wan L, Zhong J, Inuzuka H, Liu P, Sarkar FH, Wei W. Cdc20: a potential novel therapeutic target for cancer treatment. Current Pharmaceutical Design. 19: 3210-4. PMID 23151139 DOI: 10.2174/1381612811319180005  0.92
2013 Wang Z, Shaik S, Inuzuka H, Wei W. Systems biology approaches in breast cancer studies Breast Cancer Metastasis and Drug Resistance: Progress and Prospects. 2147483647: 329-340. DOI: 10.1007/978-1-4614-5647-6_18  0.92
2012 Wang Z, Inuzuka H, Zhong J, Liu P, Sarkar FH, Sun Y, Wei W. Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2. Oncotarget. 3: 1294-300. PMID 23230084 DOI: 10.18632/oncotarget.740  0.92
2012 Wang Z, Inuzuka H, Zhong J, Fukushima H, Wan L, Liu P, Wei W. DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction. Oncotarget. 3: 1026-35. PMID 22976441 DOI: 10.18632/oncotarget.640  0.92
2012 Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, ... ... Wei W, et al. Acetylation-dependent regulation of Skp2 function. Cell. 150: 179-93. PMID 22770219 DOI: 10.1016/j.cell.2012.05.038  0.92
2012 Wang Z, Zhong J, Inuzuka H, Gao D, Shaik S, Sarkar FH, Wei W. An evolving role for DEPTOR in tumor development and progression. Neoplasia (New York, N.Y.). 14: 368-75. PMID 22745583 DOI: 10.1593/neo.12542  0.92
2012 Shaik S, Nucera C, Inuzuka H, Gao D, Garnaas M, Frechette G, Harris L, Wan L, Fukushima H, Husain A, Nose V, Fadda G, Sadow PM, Goessling W, North T, ... ... Wei W, et al. SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2. The Journal of Experimental Medicine. 209: 1289-307. PMID 22711876 DOI: 10.1084/jem.20112446  0.92
2012 Fukushima H, Matsumoto A, Inuzuka H, Zhai B, Lau AW, Wan L, Gao D, Shaik S, Yuan M, Gygi SP, Jimi E, Asara JM, Nakayama K, Nakayama KI, Wei W. SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction. Cell Reports. 1: 434-43. PMID 22708077 DOI: 10.1016/j.celrep.2012.04.002  0.92
2012 Wang Z, Wei W, Sarkar FH. miR-23a, a critical regulator of "migR"ation and metastasis in colorectal cancer. Cancer Discovery. 2: 489-91. PMID 22684455 DOI: 10.1158/2159-8290.CD-12-0177  0.92
2012 Wang Z, Inuzuka H, Zhong J, Wan L, Fukushima H, Sarkar FH, Wei W. Tumor suppressor functions of FBW7 in cancer development and progression. Febs Letters. 586: 1409-18. PMID 22673505 DOI: 10.1016/j.febslet.2012.03.017  0.92
2012 Lau AW, Fukushima H, Wei W. The Fbw7 and betaTRCP E3 ubiquitin ligases and their roles in tumorigenesis. Frontiers in Bioscience (Landmark Edition). 17: 2197-212. PMID 22652772 DOI: 10.2741/4045  0.92
2012 Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KK, Flores LG, Shao Y, Hazle JD, Yu D, Wei W, Sarbassov D, Hung MC, et al. The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell. 149: 1098-111. PMID 22632973 DOI: 10.1016/j.cell.2012.02.065  0.92
2012 Min SH, Lau AW, Lee TH, Inuzuka H, Wei S, Huang P, Shaik S, Lee DY, Finn G, Balastik M, Chen CH, Luo M, Tron AE, Decaprio JA, Zhou XZ, ... Wei W, et al. Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase. Molecular Cell. 46: 771-83. PMID 22608923 DOI: 10.1016/j.molcel.2012.04.012  0.92
2012 Wang Z, Zhong J, Gao D, Inuzuka H, Liu P, Wei W. DEPTOR ubiquitination and destruction by SCF(β-TrCP). American Journal of Physiology. Endocrinology and Metabolism. 303: E163-9. PMID 22454292 DOI: 10.1152/ajpendo.00105.2012  0.92
2012 Wang G, Wang Z, Sarkar FH, Wei W. Targeting prostate cancer stem cells for cancer therapy. Discovery Medicine. 13: 135-42. PMID 22369972  0.92
2012 Wang Z, Fukushima H, Inuzuka H, Wan L, Liu P, Gao D, Sarkar FH, Wei W. Skp2 is a promising therapeutic target in breast cancer. Frontiers in Oncology. 1. PMID 22279619 DOI: 10.3389/fonc.2011.00057  0.92
2012 Wang Z, Inuzuka H, Fukushima H, Wan L, Gao D, Shaik S, Sarkar FH, Wei W. Emerging roles of the FBW7 tumour suppressor in stem cell differentiation. Embo Reports. 13: 36-43. PMID 22157894 DOI: 10.1038/embor.2011.231  0.92
2012 Wang Z, Gao D, Fukushima H, Inuzuka H, Liu P, Wan L, Sarkar FH, Wei W. Skp2: a novel potential therapeutic target for prostate cancer. Biochimica Et Biophysica Acta. 1825: 11-7. PMID 21963805 DOI: 10.1016/j.bbcan.2011.09.002  0.92
2011 Wan L, Zou W, Gao D, Inuzuka H, Fukushima H, Berg AH, Drapp R, Shaik S, Hu D, Lester C, Eguren M, Malumbres M, Glimcher LH, Wei W. Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1. Molecular Cell. 44: 721-33. PMID 22152476 DOI: 10.1016/j.molcel.2011.09.024  0.92
2011 Gao D, Inuzuka H, Tan MK, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S, Lyssiotis CA, Gygi SP, Toker A, Cantley LC, Asara JM, ... ... Wei W, et al. mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Molecular Cell. 44: 290-303. PMID 22017875 DOI: 10.1016/j.molcel.2011.08.030  0.92
2011 Wang Z, Fukushima H, Gao D, Inuzuka H, Wan L, Lau AW, Liu P, Wei W. The two faces of FBW7 in cancer drug resistance. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 33: 851-9. PMID 22006825 DOI: 10.1002/bies.201100101  0.92
2011 Inuzuka H, Fukushima H, Shaik S, Liu P, Lau AW, Wei W. Mcl-1 ubiquitination and destruction. Oncotarget. 2: 239-44. PMID 21608150  0.92
2011 Wei W, Kaelin WG. Good COP1 or bad COP1? In vivo veritas. The Journal of Clinical Investigation. 121: 1263-5. PMID 21403396 DOI: 10.1172/JCI57080  0.92
2011 Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, ... ... Wei W, et al. SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature. 471: 104-9. PMID 21368833 DOI: 10.1038/nature09732  0.92
2010 Inuzuka H, Fukushima H, Shaik S, Wei W. Novel insights into the molecular mechanisms governing Mdm2 ubiquitination and destruction. Oncotarget. 1: 685-90. PMID 21317463 DOI: 10.18632/oncotarget.101011  0.92
2010 Gao D, Wan L, Wei W. Phosphorylation of Rictor at Thr1135 impairs the Rictor/Cullin-1 complex to ubiquitinate SGK1. Protein & Cell. 1: 881-5. PMID 21204013 DOI: 10.1007/s13238-010-0123-x  0.92
2010 Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennett E, Tron AE, Gasser JA, Lau A, Gygi SP, Harper JW, DeCaprio JA, Toker A, ... Wei W, et al. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Molecular Cell. 39: 797-808. PMID 20832730 DOI: 10.1016/j.molcel.2010.08.016  0.92
2010 Inuzuka H, Tseng A, Gao D, Zhai B, Zhang Q, Shaik S, Wan L, Ang XL, Mock C, Yin H, Stommel JM, Gygi S, Lahav G, Asara J, Xiao ZX, ... ... Wei W, et al. Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell. 18: 147-59. PMID 20708156 DOI: 10.1016/j.ccr.2010.06.015  0.92
2010 Singh A, Ye M, Bucur O, Zhu S, Tanya Santos M, Rabinovitz I, Wei W, Gao D, Hahn WC, Khosravi-Far R. Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT. Molecular Biology of the Cell. 21: 1140-52. PMID 20110348 DOI: 10.1091/mbc.E09-09-0795  0.92
2009 Gao D, Inuzuka H, Tseng A, Wei W. Akt finds its new path to regulate cell cycle through modulating Skp2 activity and its destruction by APC/Cdh1. Cell Division. 4: 11. PMID 19549334 DOI: 10.1186/1747-1028-4-11  0.92
2009 Gao D, Inuzuka H, Korenjak M, Tseng A, Wu T, Wan L, Kirschner M, Dyson N, Wei W. Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. Molecular Biology of the Cell. 20: 3305-16. PMID 19477924 DOI: 10.1091/mbc.E09-01-0092  0.92
2009 Gao D, Inuzuka H, Tseng A, Chin RY, Toker A, Wei W. Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. Nature Cell Biology. 11: 397-408. PMID 19270695 DOI: 10.1038/ncb1847  0.92
2008 Tseng A, Inuzuka H, Gao D, Singh A, Wei W. Experimental approaches to investigate the proteasomal degradation pathways involved in regulation of apoptosis. Methods in Enzymology. 446: 205-23. PMID 18603124 DOI: 10.1016/S0076-6879(08)01612-1  0.92
2007 Binné UK, Classon MK, Dick FA, Wei W, Rape M, Kaelin WG, Näär AM, Dyson NJ. Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit. Nature Cell Biology. 9: 225-32. PMID 17187060 DOI: 10.1038/ncb1532  0.92
2005 Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, Farese RV, Freeman RS, Carter BD, Kaelin WG, Schlisio S. Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer. Cancer Cell. 8: 155-67. PMID 16098468 DOI: 10.1016/j.ccr.2005.06.015  0.92
2005 Wei W, Jin J, Schlisio S, Harper JW, Kaelin WG. The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase. Cancer Cell. 8: 25-33. PMID 16023596 DOI: 10.1016/j.ccr.2005.06.005  0.92
2004 Yuan ZL, Guan YJ, Wang L, Wei W, Kane AB, Chin YE. Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells. Molecular and Cellular Biology. 24: 9390-400. PMID 15485908 DOI: 10.1128/MCB.24.21.9390-9400.2004  0.92
2004 Zhang GJ, Safran M, Wei W, Sorensen E, Lassota P, Zhelev N, Neuberg DS, Shapiro G, Kaelin WG. Bioluminescent imaging of Cdk2 inhibition in vivo. Nature Medicine. 10: 643-8. PMID 15122251 DOI: 10.1038/nm1047  0.92
2004 Wei W, Ayad NG, Wan Y, Zhang GJ, Kirschner MW, Kaelin WG. Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature. 428: 194-8. PMID 15014503 DOI: 10.1038/nature02381  0.92
2004 Martin-Ruiz C, Saretzki G, Petrie J, Ladhoff J, Jeyapalan J, Wei W, Sedivy J, von Zglinicki T. Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span. The Journal of Biological Chemistry. 279: 17826-33. PMID 14963037 DOI: 10.1074/jbc.M311980200  0.92
2003 Herbig U, Wei W, Dutriaux A, Jobling WA, Sedivy JM. Real-time imaging of transcriptional activation in live cells reveals rapid up-regulation of the cyclin-dependent kinase inhibitor gene CDKN1A in replicative cellular senescence. Aging Cell. 2: 295-304. PMID 14677632  0.92
2003 Wei W, Herbig U, Wei S, Dutriaux A, Sedivy JM. Loss of retinoblastoma but not p16 function allows bypass of replicative senescence in human fibroblasts. Embo Reports. 4: 1061-6. PMID 14566323 DOI: 10.1038/sj.embor.embor7400001  0.92
2003 Hemmer R, Wei W, Dutriaux A, Sedivy J. Somatic cell knockouts of tumor suppressor genes. Methods in Molecular Biology (Clifton, N.J.). 223: 187-206. PMID 12777730 DOI: 10.1385/1-59259-329-1:187  0.6
2003 Wei W, Jobling WA, Chen W, Hahn WC, Sedivy JM. Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts. Molecular and Cellular Biology. 23: 2859-70. PMID 12665584 DOI: 10.1128/MCB.23.8.2859-2870.2003  0.92
2002 Wang Z, Bhattacharya N, Mixter PF, Wei W, Sedivy J, Magnuson NS. Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase. Biochimica Et Biophysica Acta. 1593: 45-55. PMID 12431783 DOI: 10.1016/S0167-4889(02)00347-6  0.92
2002 Han Z, Wei W, Dunaway S, Darnowski JW, Calabresi P, Sedivy J, Hendrickson EA, Balan KV, Pantazis P, Wyche JH. Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin. The Journal of Biological Chemistry. 277: 17154-60. PMID 11877436 DOI: 10.1074/jbc.M112401200  0.92
2001 Wei W, Hemmer RM, Sedivy JM. Role of p14(ARF) in replicative and induced senescence of human fibroblasts. Molecular and Cellular Biology. 21: 6748-57. PMID 11564860 DOI: 10.1128/MCB.21.20.6748-6757.2001  0.92
1999 Wei W, Sedivy JM. Differentiation between senescence (M1) and crisis (M2) in human fibroblast cultures. Experimental Cell Research. 253: 519-22. PMID 10585275 DOI: 10.1006/excr.1999.4665  0.92
1999 Wei S, Wei S, Sedivy JM. Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts. Cancer Research. 59: 1539-43. PMID 10197626  0.92
1998 Counter CM, Hahn WC, Wei W, Caddle SD, Beijersbergen RL, Lansdorp PM, Sedivy JM, Weinberg RA. Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proceedings of the National Academy of Sciences of the United States of America. 95: 14723-8. PMID 9843956 DOI: 10.1073/pnas.95.25.14723  0.92
1997 Brown JP, Wei W, Sedivy JM. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Science (New York, N.Y.). 277: 831-4. PMID 9242615  0.92
1997 Brown JP, Wei W, Sedivy JM. Bypass of senescenoe after disruption of p21(CIP1)/(WAF1) gene in normal diploid human fibroblasts Science. 277: 831-834. DOI: 10.1126/science.277.5327.831  0.92
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