| Year |
Citation |
Score |
| 2024 |
Ma J, Li L, Ma B, Liu T, Wang Z, Ye Q, Peng Y, Wang B, Chen Y, Xu S, Wang K, Dang F, Wang X, Zeng Z, Jian Y, ... ... Wei W, et al. MYC induces CDK4/6 inhibitors resistance by promoting pRB1 degradation. Nature Communications. 15: 1871. PMID 38424044 DOI: 10.1038/s41467-024-45796-w |
0.305 |
|
| 2023 |
Wang Z, Liu J, Chen H, Qiu X, Xie L, Kaniskan HÜ, Chen X, Jin J, Wei W. Telomere Targeting Chimera Enables Targeted Destruction of Telomeric Repeat-Binding Factor Proteins. Journal of the American Chemical Society. PMID 37141574 DOI: 10.1021/jacs.3c02783 |
0.318 |
|
| 2023 |
Rezaeian AH, Phan LM, Zhou X, Wei W, Inuzuka H. Pharmacological inhibition of the SKP2/p300 signaling axis restricts castration-resistant prostate cancer. Neoplasia (New York, N.Y.). 38: 100890. PMID 36871351 DOI: 10.1016/j.neo.2023.100890 |
0.33 |
|
| 2022 |
Rezaeian AH, Inuzuka H, Wei W. Insights into the aberrant CDK4/6 signaling pathway as a therapeutic target in tumorigenesis. Advances in Protein Chemistry and Structural Biology. 135: 179-201. PMID 37061331 DOI: 10.1016/bs.apcsb.2022.11.009 |
0.318 |
|
| 2022 |
Wu X, Xie W, Xie W, Wei W, Guo J. Beyond controlling cell size: functional analyses of S6K in tumorigenesis. Cell Death & Disease. 13: 646. PMID 35879299 DOI: 10.1038/s41419-022-05081-4 |
0.348 |
|
| 2022 |
Dai X, Zhang X, Yin Q, Hu J, Guo J, Gao Y, Snell AH, Inuzuka H, Wan L, Wei W. Acetylation-dependent regulation of BRAF oncogenic function. Cell Reports. 38: 110250. PMID 35045286 DOI: 10.1016/j.celrep.2021.110250 |
0.304 |
|
| 2021 |
Kishikawa T, Higuchi H, Wang L, Panch N, Maymi V, Best S, Lee S, Notoya G, Toker A, Matesic LE, Wulf GM, Wei W, Otsuka M, Koike K, Clohessy JG, et al. WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models. The Journal of Clinical Investigation. 131. PMID 34907909 DOI: 10.1172/JCI140436 |
0.304 |
|
| 2021 |
Shimizu K, Gi M, Suzuki S, North BJ, Watahiki A, Fukumoto S, Asara JM, Tokunaga F, Wei W, Inuzuka H. Interplay between protein acetylation and ubiquitination controls MCL1 protein stability. Cell Reports. 37: 109988. PMID 34758305 DOI: 10.1016/j.celrep.2021.109988 |
0.348 |
|
| 2021 |
Liu J, Peng Y, Wei W. Cell cycle on the crossroad of tumorigenesis and cancer therapy. Trends in Cell Biology. PMID 34304958 DOI: 10.1016/j.tcb.2021.07.001 |
0.313 |
|
| 2021 |
Zhang W, Li L, Cai L, Liang Y, Xu J, Liu Y, Zhou L, Ding C, Zhang Y, Zhao H, Qin J, Shao Z, Wei W, Jia L. Tumor-associated antigen Prame targets tumor suppressor p14/ARF for degradation as the receptor protein of CRL2 complex. Cell Death and Differentiation. PMID 33504946 DOI: 10.1038/s41418-020-00724-5 |
0.349 |
|
| 2020 |
Dang F, Nie L, Wei W. Ubiquitin signaling in cell cycle control and tumorigenesis. Cell Death and Differentiation. PMID 33130827 DOI: 10.1038/s41418-020-00648-0 |
0.37 |
|
| 2020 |
Hoshikawa S, Shimizu K, Watahiki A, Chiba M, Saito K, Wei W, Fukumoto S, Inuzuka H. Phosphorylation-dependent osterix degradation negatively regulates osteoblast differentiation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32931083 DOI: 10.1096/Fj.202001340R |
0.44 |
|
| 2020 |
Zhang S, Shen Y, Li H, Bi C, Sun Y, Xiong X, Wei W, Sun Y. The Negative Cross-Talk between SAG/RBX2/ROC2 and APC/C E3 Ligases in Regulation of Cell Cycle Progression and Drug Resistance. Cell Reports. 32: 108102. PMID 32905768 DOI: 10.1016/J.Celrep.2020.108102 |
0.338 |
|
| 2020 |
Liu J, Peng Y, Shi L, Wan L, Inuzuka H, Long J, Guo J, Zhang J, Yuan M, Zhang S, Wang X, Gao J, Dai X, Furumoto S, Jia L, ... ... Wei W, et al. Author Correction: Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle. Cell Research. PMID 32859994 DOI: 10.1038/S41422-020-00406-4 |
0.303 |
|
| 2020 |
Wang M, Liu J, Zhao Y, He R, Xu X, Guo X, Li X, Xu S, Miao J, Guo J, Zhang H, Gong J, Zhu F, Tian R, Shi C, ... ... Wei W, et al. Upregulation of METTL14 mediates the elevation of PERP mRNA N adenosine methylation promoting the growth and metastasis of pancreatic cancer. Molecular Cancer. 19: 130. PMID 32843065 DOI: 10.1186/S12943-020-01249-8 |
0.3 |
|
| 2020 |
Liu J, Peng Y, Shi L, Wan L, Inuzuka H, Long J, Guo J, Zhang J, Yuan M, Zhang S, Wang X, Gao J, Dai X, Furumoto S, Jia L, ... ... Wei W, et al. Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle. Cell Research. PMID 32669607 DOI: 10.1038/S41422-020-0372-Z |
0.391 |
|
| 2020 |
Lee YR, Yehia L, Kishikawa T, Ni Y, Leach B, Zhang J, Panch N, Liu J, Wei W, Eng C, Pandolfi PP. WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition. The New England Journal of Medicine. 382: 2103-2116. PMID 32459922 DOI: 10.1056/Nejmoa1914919 |
0.332 |
|
| 2020 |
Wang P, Dai X, Jiang W, Li Y, Wei W. RBR E3 ubiquitin ligases in tumorigenesis. Seminars in Cancer Biology. PMID 32442483 DOI: 10.1016/J.Semcancer.2020.05.002 |
0.358 |
|
| 2020 |
Wang Z, Song Y, Ye M, Dai X, Zhu X, Wei W. The diverse roles of SPOP in prostate cancer and kidney cancer. Nature Reviews. Urology. PMID 32355326 DOI: 10.1038/S41585-020-0314-Z |
0.355 |
|
| 2020 |
Li L, Zhang W, Liu Y, Liu X, Cai L, Kang J, Zhang Y, Chen W, Dong C, Zhang Y, Wang M, Wei W, Jia L. The CRL3 E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration. Signal Transduction and Targeted Therapy. 5: 42. PMID 32327643 DOI: 10.1038/S41392-020-0140-Z |
0.436 |
|
| 2020 |
Deng L, Meng T, Chen L, Wei W, Wang P. The role of ubiquitination in tumorigenesis and targeted drug discovery. Signal Transduction and Targeted Therapy. 5: 11. PMID 32296023 DOI: 10.1038/S41392-020-0107-0 |
0.442 |
|
| 2020 |
Deng L, Meng T, Chen L, Wei W, Wang P. The role of ubiquitination in tumorigenesis and targeted drug discovery. Signal Transduction and Targeted Therapy. 5: 11. PMID 32140262 DOI: 10.1038/s41392-020-0107-0 |
0.334 |
|
| 2020 |
Liu J, Chen H, Ma L, He Z, Wang D, Liu Y, Lin Q, Zhang T, Gray N, Kaniskan HÜ, Jin J, Wei W. Light-induced control of protein destruction by opto-PROTAC. Science Advances. 6: eaay5154. PMID 32128407 DOI: 10.1126/Sciadv.Aay5154 |
0.308 |
|
| 2020 |
Liu J, Ma J, Liu Y, Xia J, Li Y, Wang ZP, Wei W. PROTACs: a novel strategy for cancer therapy. Seminars in Cancer Biology. PMID 32058059 DOI: 10.1016/J.Semcancer.2020.02.006 |
0.369 |
|
| 2020 |
Chen WL, Jin X, Wang M, Liu D, Luo Q, Tian H, Cai L, Meng L, Bi R, Wang L, Xie X, Yu G, Li L, Dong C, Cai Q, ... ... Wei W, et al. GLUT5-mediated fructose utilization drives lung cancer growth by stimulating fatty acid synthesis and AMPK/mTORC1 signaling. Jci Insight. 5. PMID 32051337 DOI: 10.1172/Jci.Insight.131596 |
0.341 |
|
| 2020 |
Gan W, Dai X, Dai X, Xie J, Yin S, Zhu J, Wang C, Liu Y, Guo J, Wang M, Liu J, Hu J, Quinton RJ, Ganem NJ, Liu P, ... ... Wei W, et al. LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control. Nature Cell Biology. PMID 32015438 DOI: 10.1038/S41556-020-0463-6 |
0.383 |
|
| 2020 |
Liu J, Peng Y, Zhang J, Long J, Liu J, Wei W. Targeting SCF E3 Ligases for Cancer Therapies. Advances in Experimental Medicine and Biology. 1217: 123-146. PMID 31898226 DOI: 10.1007/978-981-15-1025-0_9 |
0.419 |
|
| 2019 |
Cheng J, Guo J, North BJ, Wang B, Cui CP, Li H, Tao K, Zhang L, Wei W. Functional analysis of deubiquitylating enzymes in tumorigenesis and development. Biochimica Et Biophysica Acta. Reviews On Cancer. 188312. PMID 31449841 DOI: 10.1016/J.Bbcan.2019.188312 |
0.395 |
|
| 2019 |
Kuai X, Li L, Chen R, Wang K, Chen M, Cui B, Zhang Y, Li J, Zhu H, Zhou H, Huang J, Qin J, Wang Z, Wei W, Gao D. SCFFBXW7/GSK3β-mediated GFI1 degradation suppresses gastric cancer cell proliferation. Cancer Research. PMID 31289136 DOI: 10.1158/0008-5472.Can-18-4032 |
0.379 |
|
| 2019 |
Zhang J, Lee YR, Dang F, Gan W, Menon AV, Katon JM, Hsu CH, Asara JM, Tibarewal P, Leslie NR, Shi Y, Pandolfi PP, Wei W. PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage. Cancer Discovery. PMID 31217297 DOI: 10.1158/2159-8290.Cd-18-0083 |
0.386 |
|
| 2019 |
Lee YR, Chen M, Lee JD, Zhang J, Lin SY, Fu TM, Chen H, Ishikawa T, Chiang SY, Katon J, Zhang Y, Shulga YV, Bester AC, Fung J, Monteleone E, ... ... Wei W, et al. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science (New York, N.Y.). 364. PMID 31097636 DOI: 10.1126/Science.Aau0159 |
0.401 |
|
| 2019 |
Guo J, Wei W. Fine-tuning AKT kinase activity through direct lysine methylation. Cell Cycle (Georgetown, Tex.). 1-6. PMID 31050579 DOI: 10.1080/15384101.2019.1609832 |
0.364 |
|
| 2019 |
Kim W, Cho YS, Wang X, Park O, Ma X, Kim H, Gan W, Jho EH, Cha B, Jeung YJ, Zhang L, Gao B, Wei W, Jiang J, Chung KS, et al. Hippo signaling is intrinsically regulated during cell cycle progression by APC/C. Proceedings of the National Academy of Sciences of the United States of America. PMID 31000600 DOI: 10.1073/Pnas.1821370116 |
0.443 |
|
| 2019 |
Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, ... ... Wei W, et al. Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nature Cell Biology. PMID 30783264 DOI: 10.1038/S41556-019-0280-Y |
0.367 |
|
| 2019 |
Guo J, Dai X, Laurent B, Zheng N, Gan W, Zhang J, Guo A, Yuan M, Liu P, Asara JM, Toker A, Shi Y, Pandolfi PP, Wei W. AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions. Nature Cell Biology. PMID 30692625 DOI: 10.1038/S41556-018-0261-6 |
0.394 |
|
| 2019 |
Fujii M, Nakayama S, Akanuma N, Pan G, Kobayashi IS, Takei H, Shimizu K, Ando M, Heo E, Gergis C, Inuzuka H, Wei W, Costa DB, Kobayashi SS. Abstract 320: Met/Ror1-β-catenin-Bcl-xL axis contributes to the emergence of drug-tolerant cells that evolve into resistant tumors inEGFR-mutant lung cancer Cancer Research. 79: 320-320. DOI: 10.1158/1538-7445.Sabcs18-320 |
0.38 |
|
| 2018 |
Cheng J, Guo J, North BJ, Tao K, Zhou P, Wei W. The emerging role for Cullin 4 family of E3 ligases in tumorigenesis. Biochimica Et Biophysica Acta. Reviews On Cancer. PMID 30602127 DOI: 10.1016/J.Bbcan.2018.11.007 |
0.372 |
|
| 2018 |
Zhang J, Chen M, Zhu Y, Dai X, Dang F, Ren J, Ren S, Shulga YV, Beca F, Gan W, Wu F, Lin YM, Zhou X, DeCaprio JA, Beck AH, ... ... Wei W, et al. SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression. Developmental Cell. PMID 30595538 DOI: 10.1016/J.Devcel.2018.11.035 |
0.396 |
|
| 2018 |
Liu S, Zhang G, Guo J, Chen X, Lei J, Ze K, Dong L, Dai X, Gao Y, Song D, Ecker B, Yang R, Feltcher C, Peng K, Feng C, ... ... Wei W, et al. Loss of Phd2 cooperates with BRAF to drive melanomagenesis. Nature Communications. 9: 5426. PMID 30575721 DOI: 10.1038/S41467-018-07126-9 |
0.381 |
|
| 2018 |
Ma Y, Cui D, Xiong X, Inuzuka H, Wei W, Sun Y, North BJ, Zhao Y. SCFβ-TrCP ubiquitinates CHK1 in an AMPK-dependent manner in response to glucose deprivation. Molecular Oncology. PMID 30428154 DOI: 10.1002/1878-0261.12403 |
0.369 |
|
| 2018 |
Cui CP, Zhang Y, Wang C, Yuan F, Li H, Yao Y, Chen Y, Li C, Wei W, Liu CH, He F, Liu Y, Zhang L. Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation. Nature Communications. 9: 4648. PMID 30405104 DOI: 10.1038/S41467-018-07025-Z |
0.342 |
|
| 2018 |
Huang LY, Zhao J, Chen H, Wan L, Inuzuka H, Guo J, Fu X, Zhai Y, Lu Z, Wang X, Han ZG, Sun Y, Wei W. SCF-mediated degradation of Brg1 suppresses gastric cancer metastasis. Nature Communications. 9: 3569. PMID 30177679 DOI: 10.1038/S41467-018-06038-Y |
0.366 |
|
| 2018 |
Chen Y, Huang Q, Liu W, Zhu Q, Cui CP, Xu L, Guo X, Wang P, Liu J, Dong G, Wei W, Liu CH, Feng Z, He F, Zhang L. Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth. Nature Communications. 9: 2464. PMID 29942010 DOI: 10.1038/S41467-018-04815-3 |
0.356 |
|
| 2018 |
Zhou W, Xu J, Tan M, Li H, Li H, Wei W, Sun Y. UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F. Molecular Cell. 70: 1008-1024.e6. PMID 29932898 DOI: 10.1016/J.Molcel.2018.06.002 |
0.317 |
|
| 2018 |
Zhang J, Guo J, Qin X, Wang B, Zhang L, Wang Y, Gan W, Pandofi PP, Chen W, Wei W. The p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth. Science Signaling. 11. PMID 29588411 DOI: 10.1126/Scisignal.Aao1052 |
0.467 |
|
| 2018 |
Clement E, Inuzuka H, Nihira NT, Wei W, Toker A. Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors. Science Signaling. 11. PMID 29535262 DOI: 10.1126/Scisignal.Aao3810 |
0.426 |
|
| 2018 |
Shimizu K, Nihira NT, Inuzuka H, Wei W. Physiological functions of FBW7 in cancer and metabolism. Cellular Signalling. PMID 29474981 DOI: 10.1016/J.Cellsig.2018.02.009 |
0.415 |
|
| 2018 |
Xie X, Hu H, Tong X, Li L, Liu X, Chen M, Yuan H, Xie X, Li Q, Zhang Y, Ouyang H, Wei M, Huang J, Liu P, Gan W, ... ... Wei W, et al. The mTOR-S6K pathway links growth signalling to DNA damage response by targeting RNF168. Nature Cell Biology. PMID 29403037 DOI: 10.1038/S41556-017-0033-8 |
0.38 |
|
| 2018 |
Wan L, Xu K, Wei Y, Zhang J, Han T, Fry C, Zhang Z, Wang YV, Huang L, Yuan M, Xia W, Chang WC, Huang WC, Liu CL, Chang YC, ... ... Wei W, et al. Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function. Molecular Cell. 69: 279-291.e5. PMID 29351847 DOI: 10.1016/J.Molcel.2017.12.024 |
0.429 |
|
| 2018 |
Zhu B, Chen S, Wang H, Yin C, Han C, Peng C, Liu Z, Wan L, Zhang X, Zhang J, Lian CG, Ma P, Xu ZX, Prince S, Wang T, ... ... Wei W, et al. The protective role of DOT1L in UV-induced melanomagenesis. Nature Communications. 9: 259. PMID 29343685 DOI: 10.1038/S41467-017-02687-7 |
0.327 |
|
| 2018 |
Chen M, Wan L, Zhang J, Zhang J, Mendez L, Clohessy JG, Berry K, Victor J, Yin Q, Zhu Y, Wei W, Pandolfi PP. Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism. Nature Communications. 9: 159. PMID 29335436 DOI: 10.1038/S41467-017-02272-Y |
0.422 |
|
| 2017 |
Cheng J, Guo J, Wang Z, North BJ, Tao K, Dai X, Wei W. Functional analysis of Cullin 3 E3 ligases in tumorigenesis. Biochimica Et Biophysica Acta. PMID 29128526 DOI: 10.1016/J.Bbcan.2017.11.001 |
0.42 |
|
| 2017 |
Dai X, Wang Z, Wei W. SPOP-mediated degradation of BRD4 dictates cellular sensitivity to BET inhibitors. Cell Cycle (Georgetown, Tex.). 0. PMID 29108467 DOI: 10.1080/15384101.2017.1388973 |
0.361 |
|
| 2017 |
Wang D, Ma L, Wang B, Liu J, Wei W. E3 ubiquitin ligases in cancer and implications for therapies. Cancer Metastasis Reviews. PMID 29043469 DOI: 10.1007/S10555-017-9703-Z |
0.349 |
|
| 2017 |
Dai X, Gan W, Li X, Wang S, Zhang W, Huang L, Liu S, Zhong Q, Guo J, Zhang J, Chen T, Shimizu K, Beca F, Blattner M, Vasudevan D, ... ... Wei W, et al. Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. Nature Medicine. PMID 28805820 DOI: 10.1038/Nm.4378 |
0.389 |
|
| 2017 |
Takada M, Zhang W, Suzuki A, Kuroda T, Yu Z, Inuzuka H, Gao D, Wan L, Zhuang M, Hu L, Zhai B, Fry C, Bloom K, Li G, Karpen G, ... Wei W, et al. FBW7 loss promotes chromosomal instability and tumorigenesis via Cyclin E1/CDK2-mediated phosphorylation of CENP-A. Cancer Research. PMID 28760857 DOI: 10.1158/0008-5472.Can-17-1240 |
0.397 |
|
| 2017 |
Guo J, Cheng J, North BJ, Wei W. Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology. Biochimica Et Biophysica Acta. PMID 28694093 DOI: 10.1016/J.Bbcan.2017.07.001 |
0.301 |
|
| 2017 |
Wang B, Jie Z, Joo D, Ordureau A, Liu P, Gan W, Guo J, Zhang J, North BJ, Dai X, Cheng X, Bian X, Zhang L, Harper JW, Sun SC, ... Wei W, et al. TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling. Nature. PMID 28489822 DOI: 10.1038/Nature22344 |
0.432 |
|
| 2017 |
Zhang J, Liu J, Wei W. "FEM1"nism controls SLBP stability during cell cycle. Cell Cycle (Georgetown, Tex.). 0. PMID 28324668 DOI: 10.1080/15384101.2017.1302226 |
0.314 |
|
| 2017 |
Wang X, Cao W, Zhang J, Yan M, Xu Q, Wu X, Wan L, Zhang Z, Zhang C, Qin X, Xiao M, Ye D, Liu Y, Han Z, Wang S, ... ... Wei W, et al. A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination. The Embo Journal. PMID 28320739 DOI: 10.15252/Embj.201694058 |
0.417 |
|
| 2017 |
Jansen VM, Bhola NE, Bauer JA, Formisano L, Lee KM, Hutchinson KE, Witkiewicz AK, Moore PD, Estrada MV, Sanchez V, Ericsson PG, Sanders M, Pohlmann PR, Pishvaian MJ, Riddle DA, ... Wei W, et al. Kinome-wide RNA interference screen reveals a role for PDK1 in acquired resistance to CDK4/6 inhibition in ER-positive breast cancer. Cancer Research. PMID 28249908 DOI: 10.1158/0008-5472.Can-16-2653 |
0.443 |
|
| 2017 |
Nihira NT, Ogura K, Shimizu K, North BJ, Zhang J, Gao D, Inuzuka H, Wei W. Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function. Science Signaling. 10. PMID 28196907 DOI: 10.1126/Scisignal.Aai8026 |
0.441 |
|
| 2017 |
Liu L, Michowski W, Inuzuka H, Shimizu K, Nihira NT, Chick JM, Li N, Geng Y, Meng AY, Ordureau A, Kołodziejczyk A, Ligon KL, Bronson RT, Polyak K, Harper JW, ... ... Wei W, et al. G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells. Nature Cell Biology. PMID 28192421 DOI: 10.1038/Ncb3474 |
0.41 |
|
| 2017 |
Wan L, Chen M, Cao J, Dai X, Yin Q, Zhang J, Song SJ, Lu Y, Liu J, Inuzuka H, Katon JM, Berry K, Fung J, Ng C, Liu P, ... ... Wei W, et al. The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. Cancer Discovery. PMID 28174173 DOI: 10.1158/2159-8290.Cd-16-0647 |
0.453 |
|
| 2017 |
Zhang L, Peng S, Dai X, Gan W, Nie X, Wei W, Hu G, Guo J. Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells. Cancer Letters. PMID 28089830 DOI: 10.1016/J.Canlet.2017.01.003 |
0.343 |
|
| 2017 |
Shimizu K, Fukushima H, Ogura K, Lien EC, Nihira NT, Zhang J, North BJ, Guo A, Nagashima K, Nakagawa T, Hoshikawa S, Watahiki A, Okabe K, Yamada A, Toker A, ... ... Wei W, et al. The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis. Science Signaling. 10. PMID 28049764 DOI: 10.1126/Scisignal.Aah4117 |
0.322 |
|
| 2016 |
Liu X, Yao Y, Ding H, Han C, Chen Y, Zhang Y, Wang C, Zhang X, Zhang Y, Zhai Y, Wang P, Wei W, Zhang J, Zhang L. USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency. Signal Transduction and Targeted Therapy. 1: 16024. PMID 29263902 DOI: 10.1038/Sigtrans.2016.24 |
0.346 |
|
| 2016 |
Wu F, Dai X, Gan W, Wan L, Li M, Mitsiades N, Wei W, Ding Q, Zhang J. Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation. Cancer Letters. PMID 27780719 DOI: 10.1016/J.Canlet.2016.10.021 |
0.379 |
|
| 2016 |
Cheng J, Zhang T, Ji H, Tao K, Guo J, Wei W. Functional characterization of AMP-activated protein kinase signaling in tumorigenesis. Biochimica Et Biophysica Acta. PMID 27681874 DOI: 10.1016/J.Bbcan.2016.09.006 |
0.397 |
|
| 2016 |
Zurlo G, Guo J, Takada M, Wei W, Zhang Q. New Insights into Protein Hydroxylation and Its Important Role in Human Diseases. Biochimica Et Biophysica Acta. PMID 27663420 DOI: 10.1016/J.Bbcan.2016.09.004 |
0.375 |
|
| 2016 |
Zheng N, Dai X, Wang Z, Wei W. A new layer of degradation mechanism for PR-Set7/Set8 during cell cycle. Cell Cycle (Georgetown, Tex.). 0. PMID 27649746 DOI: 10.1080/15384101.2016.1234552 |
0.372 |
|
| 2016 |
Zhou W, Xu J, Li H, Xu M, Chen ZJ, Wei W, Pan ZQ, Sun Y. Neddylation E2 UBE2F promotes the survival of lung cancer cells by activating CRL5 to degrade NOXA via the K11 linkage. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27591266 DOI: 10.1158/1078-0432.Ccr-16-1585 |
0.372 |
|
| 2016 |
Guo J, Chakraborty AA, Liu P, Gan W, Zheng X, Inuzuka H, Wang B, Zhang J, Zhang L, Yuan M, Novak J, Cheng JQ, Toker A, Signoretti S, Zhang Q, ... ... Wei W, et al. pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner. Science (New York, N.Y.). 353: 929-32. PMID 27563096 DOI: 10.1126/Science.Aad5755 |
0.436 |
|
| 2016 |
Liu J, Wan L, Liu J, Yuan Z, Zhang J, Guo J, Malumbres M, Liu J, Zou W, Wei W. Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner. Cell Discovery. 2: 15044. PMID 27462441 DOI: 10.1038/Celldisc.2015.44 |
0.418 |
|
| 2016 |
Zhang J, Xu K, Liu P, Geng Y, Wang B, Gan W, Guo J, Wu F, Chin YR, Berrios C, Lien EC, Toker A, DeCaprio JA, Sicinski P, Wei W. Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt. Molecular Cell. PMID 27237051 DOI: 10.1016/J.Molcel.2016.04.023 |
0.459 |
|
| 2016 |
Zheng N, Zhou Q, Wang Z, Wei W. Recent advances in SCF ubiquitin ligase complex: Clinical implications. Biochimica Et Biophysica Acta. PMID 27156687 DOI: 10.1016/J.Bbcan.2016.05.001 |
0.337 |
|
| 2016 |
Shao R, Liu J, Yan G, Zhang J, Han Y, Guo J, Xu Z, Yuan Z, Liu J, Malumbres M, Wan L, Wei W, Zou W. Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid. Cell Research. PMID 27126000 DOI: 10.1038/Cr.2016.51 |
0.345 |
|
| 2016 |
Zheng N, Wang Z, Wei W. Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteins. The International Journal of Biochemistry & Cell Biology. PMID 26860958 DOI: 10.1016/J.Biocel.2016.02.005 |
0.385 |
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| 2016 |
Qin X, Yan M, Zhang J, Wang X, Shen Z, Lv Z, Li Z, Wei W, Chen W. TGFβ3-mediated induction of Periostin facilitates head and neck cancer growth and is associated with metastasis. Scientific Reports. 6: 20587. PMID 26857387 DOI: 10.1038/Srep20587 |
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Wang Z, Dai X, Zhong J, Inuzuka H, Wan L, Li X, Wang L, Ye X, Sun L, Gao D, Zou L, Wei W. SCF(β-TRCP) promotes cell growth by targeting PR-Set7/Set8 for degradation. Nature Communications. 6: 10185. PMID 26666832 DOI: 10.1038/Ncomms10185 |
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Gan W, Dai X, Lunardi A, Li Z, Inuzuka H, Liu P, Varmeh S, Zhang J, Cheng L, Sun Y, Asara JM, Beck AH, Huang J, Pandolfi PP, Wei W. SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression. Molecular Cell. PMID 26344095 DOI: 10.1016/J.Molcel.2015.07.026 |
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Liu P, Gan W, Chin YR, Ogura K, Guo J, Zhang J, Wang B, Blenis J, Cantley LC, Toker A, Su B, Wei W. PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex. Cancer Discovery. 5: 1194-209. PMID 26293922 DOI: 10.1158/2159-8290.Cd-15-0460 |
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Gan W, Liu P, Wei W. Akt promotes tumorigenesis in part through modulating genomic instability via phosphorylating XLF. Nucleus (Austin, Tex.). 6: 261-5. PMID 26225792 DOI: 10.1080/19491034.2015.1074365 |
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Gan W, Liu P, Wei W. Cell cycle status dictates effectiveness of rapamycin. Cell Cycle (Georgetown, Tex.). 1-2. PMID 26126171 DOI: 10.1080/15384101.2015.1060778 |
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Wang L, Zhang J, Wan L, Zhou X, Wang Z, Wei W. Targeting Cdc20 as a novel cancer therapeutic strategy. Pharmacology & Therapeutics. 151: 141-151. PMID 25850036 DOI: 10.1016/J.Pharmthera.2015.04.002 |
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Liu P, Gan W, Guo C, Xie A, Gao D, Guo J, Zhang J, Willis N, Su A, Asara JM, Scully R, Wei W. Akt-mediated phosphorylation of XLF impairs non-homologous end-joining DNA repair. Molecular Cell. 57: 648-61. PMID 25661488 DOI: 10.1016/J.Molcel.2015.01.005 |
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Su J, Yin X, Zhou X, Wei W, Wang Z. The functions of F-box proteins in regulating the epithelial to mesenchymal transition. Current Pharmaceutical Design. 21: 1311-7. PMID 25506894 DOI: 10.2174/1381612821666141211144203 |
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Liu J, Shaik S, Dai X, Wu Q, Zhou X, Wang Z, Wei W. Targeting the ubiquitin pathway for cancer treatment. Biochimica Et Biophysica Acta. 1855: 50-60. PMID 25481052 DOI: 10.1016/J.Bbcan.2014.11.005 |
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Gasser JA, Inuzuka H, Lau AW, Wei W, Beroukhim R, Toker A. SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer. Molecular Cell. 56: 595-607. PMID 25458846 DOI: 10.1016/J.Molcel.2014.09.023 |
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Xu K, Liu P, Wei W. mTOR signaling in tumorigenesis. Biochimica Et Biophysica Acta. 1846: 638-54. PMID 25450580 DOI: 10.1016/J.Bbcan.2014.10.007 |
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Ye X, Wang L, Shang B, Wang Z, Wei W. NEDD4: a promising target for cancer therapy. Current Cancer Drug Targets. 14: 549-56. PMID 25088038 DOI: 10.2174/1568009614666140725092430 |
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Wu X, Fukushima H, North BJ, Nagaoka Y, Nagashima K, Deng F, Okabe K, Inuzuka H, Wei W. SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination. Oncotarget. 5: 4211-21. PMID 24961988 DOI: 10.18632/Oncotarget.1971 |
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Liu P, Wang Z, Wei W. Phosphorylation of Akt at the C-terminal tail triggers Akt activation. Cell Cycle (Georgetown, Tex.). 13: 2162-4. PMID 24933731 DOI: 10.4161/Cc.29584 |
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Wang L, Ye X, Liu Y, Wei W, Wang Z. Aberrant regulation of FBW7 in cancer. Oncotarget. 5: 2000-15. PMID 24899581 DOI: 10.18632/Oncotarget.1859 |
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Wan L, Tan M, Yang J, Inuzuka H, Dai X, Wu T, Liu J, Shaik S, Chen G, Deng J, Malumbres M, Letai A, Kirschner MW, Sun Y, Wei W. APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction. Developmental Cell. 29: 377-91. PMID 24871945 DOI: 10.1016/J.Devcel.2014.04.022 |
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Liu J, Wan L, Liu P, Inuzuka H, Liu J, Wang Z, Wei W. SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway. Oncotarget. 5: 1026-37. PMID 24657926 DOI: 10.18632/Oncotarget.1675 |
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Zhang J, Wan L, Dai X, Sun Y, Wei W. Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis. Biochimica Et Biophysica Acta. 1845: 277-93. PMID 24569229 DOI: 10.1016/J.Bbcan.2014.02.001 |
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Liu P, Guo J, Gan W, Wei W. Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity. Protein & Cell. 5: 171-7. PMID 24481632 DOI: 10.1007/S13238-014-0021-8 |
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Zhong J, Shaik S, Wan L, Tron AE, Wang Z, Sun L, Inuzuka H, Wei W. SCF β-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration. Oncotarget. 4: 2339-53. PMID 24318128 DOI: 10.18632/Oncotarget.1446 |
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Fukushima H, Ogura K, Wan L, Lu Y, Li V, Gao D, Liu P, Lau AW, Wu T, Kirschner MW, Inuzuka H, Wei W. SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. Cell Reports. 4: 803-16. PMID 23972993 DOI: 10.1016/J.Celrep.2013.07.031 |
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Lau AW, Inuzuka H, Fukushima H, Wan L, Liu P, Gao D, Sun Y, Wei W. Regulation of APC(Cdh1) E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7. Cell Research. 23: 947-61. PMID 23670162 DOI: 10.1038/Cr.2013.67 |
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Zhou W, Wei W, Sun Y. Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligases. Cell Research. 23: 599-619. PMID 23528706 DOI: 10.1038/Cr.2013.44 |
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Liu F, Cao J, Wu J, Sullivan K, Shen J, Ryu B, Xu Z, Wei W, Cui R. Stat3-targeted therapies overcome the acquired resistance to vemurafenib in melanomas. The Journal of Investigative Dermatology. 133: 2041-9. PMID 23344460 DOI: 10.1038/Jid.2013.32 |
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Chen H, Ma H, Inuzuka H, Diao J, Lan F, Shi YG, Wei W, Shi Y. DNA damage regulates UHRF1 stability via the SCF(β-TrCP) E3 ligase. Molecular and Cellular Biology. 33: 1139-48. PMID 23297342 DOI: 10.1128/Mcb.01191-12 |
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Wang Z, Wan L, Zhong J, Inuzuka H, Liu P, Sarkar FH, Wei W. Cdc20: a potential novel therapeutic target for cancer treatment. Current Pharmaceutical Design. 19: 3210-4. PMID 23151139 DOI: 10.2174/1381612811319180005 |
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Wang Z, Inuzuka H, Zhong J, Liu P, Sarkar FH, Sun Y, Wei W. Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2. Oncotarget. 3: 1294-300. PMID 23230084 DOI: 10.18632/Oncotarget.740 |
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Wei W, Lin HK. The key role of ubiquitination and sumoylation in signaling and cancer: a research topic. Frontiers in Oncology. 2: 187. PMID 23227454 DOI: 10.3389/Fonc.2012.00187 |
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Wang Z, Inuzuka H, Zhong J, Fukushima H, Wan L, Liu P, Wei W. DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction. Oncotarget. 3: 1026-35. PMID 22976441 DOI: 10.18632/Oncotarget.640 |
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Wang Z, Zhong J, Inuzuka H, Gao D, Shaik S, Sarkar FH, Wei W. An evolving role for DEPTOR in tumor development and progression. Neoplasia (New York, N.Y.). 14: 368-75. PMID 22745583 DOI: 10.1593/Neo.12542 |
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Wan L, Zou W, Gao D, Inuzuka H, Fukushima H, Berg AH, Drapp R, Shaik S, Hu D, Lester C, Eguren M, Malumbres M, Glimcher LH, Wei W. Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1. Molecular Cell. 44: 721-33. PMID 22152476 DOI: 10.1016/J.Molcel.2011.09.024 |
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Wei W, Kaelin WG. Good COP1 or bad COP1? In vivo veritas. The Journal of Clinical Investigation. 121: 1263-5. PMID 21403396 DOI: 10.1172/Jci57080 |
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Gao D, Wan L, Wei W. Phosphorylation of Rictor at Thr1135 impairs the Rictor/Cullin-1 complex to ubiquitinate SGK1. Protein & Cell. 1: 881-5. PMID 21204013 DOI: 10.1007/S13238-010-0123-X |
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Inuzuka H, Tseng A, Gao D, Zhai B, Zhang Q, Shaik S, Wan L, Ang XL, Mock C, Yin H, Stommel JM, Gygi S, Lahav G, Asara J, Xiao ZX, ... ... Wei W, et al. Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell. 18: 147-59. PMID 20708156 DOI: 10.1016/J.Ccr.2010.06.015 |
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Gao D, Inuzuka H, Tseng A, Wei W. Akt finds its new path to regulate cell cycle through modulating Skp2 activity and its destruction by APC/Cdh1. Cell Division. 4: 11. PMID 19549334 DOI: 10.1186/1747-1028-4-11 |
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Gao D, Inuzuka H, Korenjak M, Tseng A, Wu T, Wan L, Kirschner M, Dyson N, Wei W. Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. Molecular Biology of the Cell. 20: 3305-16. PMID 19477924 DOI: 10.1091/Mbc.E09-01-0092 |
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Wei W, Hemmer RM, Sedivy JM. Role of p14(ARF) in replicative and induced senescence of human fibroblasts. Molecular and Cellular Biology. 21: 6748-57. PMID 11564860 DOI: 10.1128/Mcb.21.20.6748-6757.2001 |
0.649 |
|
| 1999 |
Wei W, Sedivy JM. Differentiation between senescence (M1) and crisis (M2) in human fibroblast cultures. Experimental Cell Research. 253: 519-22. PMID 10585275 DOI: 10.1006/Excr.1999.4665 |
0.588 |
|
| 1998 |
Counter CM, Hahn WC, Wei W, Caddle SD, Beijersbergen RL, Lansdorp PM, Sedivy JM, Weinberg RA. Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proceedings of the National Academy of Sciences of the United States of America. 95: 14723-8. PMID 9843956 DOI: 10.1073/Pnas.95.25.14723 |
0.63 |
|
| 1997 |
Brown JP, Wei W, Sedivy JM. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Science (New York, N.Y.). 277: 831-4. PMID 9242615 DOI: 10.1126/Science.277.5327.831 |
0.659 |
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| 1997 |
Brown JP, Wei W, Sedivy JM. Bypass of senescenoe after disruption of p21(CIP1)/(WAF1) gene in normal diploid human fibroblasts Science. 277: 831-834. DOI: 10.1126/science.277.5327.831 |
0.618 |
|
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