| Year |
Citation |
Score |
| 2019 |
Adeosun SO, Hou X, Shi L, Stockmeier CA, Zheng B, Raffai RL, Weisgraber KH, Mosley TH, Ming Wang J. Female Mice with Apolipoprotein E4 Domain Interaction Demonstrated Impairments in Spatial Learning and Memory Performance and Disruption of Hippocampal Cyto-Architecture. Neurobiology of Learning and Memory. PMID 30954674 DOI: 10.1016/J.Nlm.2019.03.012 |
0.319 |
|
| 2015 |
Adeosun SO, Hou X, Zhao X, Stockmeier C, Mosley T, Zheng B, Raffai R, Zhang Q, Weisgraber KH, Wang JM. P2-028: Apolipoprotein e ε4 domain interaction in size of hippocampal subregions, density of newborn neurons, and cognitive behaviors Alzheimer's & Dementia. 11: P491-P492. DOI: 10.1016/J.Jalz.2015.06.564 |
0.351 |
|
| 2014 |
Adeosun SO, Hou X, Zheng B, Stockmeier C, Ou X, Paul I, Mosley T, Weisgraber K, Wang JM. Cognitive deficits and disruption of neurogenesis in a mouse model of apolipoprotein E4 domain interaction. The Journal of Biological Chemistry. 289: 2946-59. PMID 24324264 DOI: 10.1074/Jbc.M113.497909 |
0.387 |
|
| 2012 |
Zhang L, Yan F, Zhang S, Lei D, Charles MA, Cavigiolio G, Oda M, Krauss RM, Weisgraber KH, Rye KA, Pownall HJ, Qiu X, Ren G. Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein. Nature Chemical Biology. 8: 342-9. PMID 22344176 DOI: 10.1038/Nchembio.796 |
0.393 |
|
| 2012 |
Peters-Libeu C, Miller J, Rutenber E, Newhouse Y, Krishnan P, Cheung K, Hatters D, Brooks E, Widjaja K, Tran T, Mitra S, Arrasate M, Mosquera LA, Taylor D, Weisgraber KH, et al. Disease-associated polyglutamine stretches in monomeric huntingtin adopt a compact structure. Journal of Molecular Biology. 421: 587-600. PMID 22306738 DOI: 10.1016/J.Jmb.2012.01.034 |
0.323 |
|
| 2012 |
Chen HK, Liu Z, Meyer-Franke A, Brodbeck J, Miranda RD, McGuire JG, Pleiss MA, Ji ZS, Balestra ME, Walker DW, Xu Q, Jeong DE, Budamagunta MS, Voss JC, Freedman SB, ... Weisgraber KH, et al. Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons. The Journal of Biological Chemistry. 287: 5253-66. PMID 22158868 DOI: 10.1074/Jbc.M111.276162 |
0.406 |
|
| 2011 |
Brodbeck J, McGuire J, Liu Z, Meyer-Franke A, Balestra ME, Jeong DE, Pleiss M, McComas C, Hess F, Witter D, Peterson S, Childers M, Goulet M, Liverton N, Hargreaves R, ... ... Weisgraber KH, et al. Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors. The Journal of Biological Chemistry. 286: 17217-26. PMID 21454574 DOI: 10.1074/Jbc.M110.217380 |
0.424 |
|
| 2011 |
Chen HK, Ji ZS, Dodson SE, Miranda RD, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Y, Mahley RW. Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease. The Journal of Biological Chemistry. 286: 5215-21. PMID 21118811 DOI: 10.1074/Jbc.M110.151084 |
0.375 |
|
| 2011 |
Zhang L, Song J, Cavigiolio G, Ishida BY, Zhang S, Kane JP, Weisgraber KH, Oda MN, Rye KA, Pownall HJ, Ren G. Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopy. Journal of Lipid Research. 52: 175-84. PMID 20978167 DOI: 10.1194/Jlr.D010959 |
0.405 |
|
| 2011 |
Newhouse Y, Weisgraber KH. Apolipoprotein E expression and purification. Methods in Molecular Biology (Clifton, N.J.). 670: 127-40. PMID 20967588 DOI: 10.1007/978-1-60761-744-0_10 |
0.418 |
|
| 2010 |
Zhang L, Song J, Newhouse Y, Zhang S, Weisgraber KH, Ren G. An optimized negative-staining protocol of electron microscopy for apoE4 POPC lipoprotein. Journal of Lipid Research. 51: 1228-36. PMID 19965615 DOI: 10.1194/Jlr.D002493 |
0.372 |
|
| 2010 |
Tetali SD, Budamagunta MS, Simion C, den Hartigh LJ, Kálai T, Hideg K, Hatters DM, Weisgraber KH, Voss JC, Rutledge JC. VLDL lipolysis products increase VLDL fluidity and convert apolipoprotein E4 into a more expanded conformation. Journal of Lipid Research. 51: 1273-83. PMID 19965582 DOI: 10.1194/Jlr.M000406 |
0.309 |
|
| 2010 |
Ren G, Zhang S, Cavigiolio G, Lei D, Oda M, Weisgraber KH, Rye K, Pownall HJ, Qiu X. Cholesteryl Ester Transfer Protein Penetrates Lipoproteins For Cholesteryl Ester Transfer Biophysical Journal. 98: 36a. DOI: 10.1016/J.Bpj.2009.12.212 |
0.405 |
|
| 2009 |
Zhong N, Weisgraber KH. Understanding the basis for the association of apoE4 with Alzheimer's disease: opening the door for therapeutic approaches. Current Alzheimer Research. 6: 415-8. PMID 19874264 DOI: 10.2174/156720509789207921 |
0.631 |
|
| 2009 |
Zhong N, Ramaswamy G, Weisgraber KH. Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function. The Journal of Biological Chemistry. 284: 27273-80. PMID 19666463 DOI: 10.1074/jbc.M109.014464 |
0.632 |
|
| 2009 |
Tesseur I, Zhang H, Brecht W, Corn J, Gong JS, Yanagisawa K, Michikawa M, Weisgraber K, Huang Y, Wyss-Coray T. Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3. Journal of Neurochemistry. 110: 1254-62. PMID 19549280 DOI: 10.1111/J.1471-4159.2009.06222.X |
0.334 |
|
| 2009 |
Hatters DM, Voss JC, Budamagunta MS, Newhouse YN, Weisgraber KH. Insight on the molecular envelope of lipid-bound apolipoprotein E from electron paramagnetic resonance spectroscopy. Journal of Molecular Biology. 386: 261-71. PMID 19124026 DOI: 10.1016/J.Jmb.2008.12.040 |
0.359 |
|
| 2009 |
Mahley RW, Weisgraber KH, Huang Y. Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS. Journal of Lipid Research. 50: S183-8. PMID 19106071 DOI: 10.1194/Jlr.R800069-Jlr200 |
0.445 |
|
| 2009 |
Zhong N, Weisgraber KH. Understanding the association of apolipoprotein E4 with Alzheimer disease: clues from its structure. The Journal of Biological Chemistry. 284: 6027-31. PMID 18948255 DOI: 10.1074/jbc.R800009200 |
0.596 |
|
| 2009 |
Xu Q, Savage MJ, Jeong M, Wu G, Brecht WJ, Hsieh S, Steele MX, Joachim C, Smith AD, Freedman SB, Weisgraber KH, Mahley RW, Huang Y. Apolipoprotein E fragmentation in human brain and CSF samples is isoform and Alzheimer's disease dependent Alzheimers & Dementia. 5. DOI: 10.1016/J.Jalz.2009.04.470 |
0.352 |
|
| 2009 |
Chen H, Ji Z, Miranda RD, McGuire J, Wong J, Vongs A, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Y, Seabrook GR, Mahley RW. Apolipoprotein E4-induced mitochondrial dysfunction depends on its structure and can be rescued by a structure corrector Alzheimers & Dementia. 5: 307. DOI: 10.1016/J.Jalz.2009.04.468 |
0.316 |
|
| 2008 |
Zhong N, Scearce-Levie K, Ramaswamy G, Weisgraber KH. Apolipoprotein E4 domain interaction: synaptic and cognitive deficits in mice. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 4: 179-92. PMID 18631967 DOI: 10.1016/j.jalz.2008.01.006 |
0.624 |
|
| 2008 |
Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubinstein E, Boucheix C, Yang X, Stanley P, ... ... Weisgraber KH, et al. Genes contributing to prion pathogenesis. The Journal of General Virology. 89: 1777-88. PMID 18559949 DOI: 10.1099/Vir.0.2008/001255-0 |
0.304 |
|
| 2008 |
Zhong N, Weisgraber KH. O3-03-02: Apolipoprotein E4 domain interaction causes astrocyte dysfunction Alzheimer's & Dementia. 4: T163-T163. DOI: 10.1016/j.jalz.2008.05.424 |
0.593 |
|
| 2007 |
Mahley RW, Huang Y, Weisgraber KH. Detrimental effects of apolipoprotein E4: potential therapeutic targets in Alzheimer's disease. Current Alzheimer Research. 4: 537-40. PMID 18220516 DOI: 10.2174/156720507783018334 |
0.387 |
|
| 2007 |
Zhang Y, Vasudevan S, Sojitrawala R, Zhao W, Cui C, Xu C, Fan D, Newhouse Y, Balestra R, Jerome WG, Weisgraber K, Li Q, Wang J. A monomeric, biologically active, full-length human apolipoprotein E. Biochemistry. 46: 10722-32. PMID 17715945 DOI: 10.1021/bi700672v |
0.468 |
|
| 2007 |
Peters-Libeu CA, Newhouse Y, Hall SC, Witkowska HE, Weisgraber KH. Apolipoprotein E*dipalmitoylphosphatidylcholine particles are ellipsoidal in solution. Journal of Lipid Research. 48: 1035-44. PMID 17308333 DOI: 10.1194/jlr.M600545-JLR200 |
0.389 |
|
| 2006 |
Hatters DM, Zhong N, Rutenber E, Weisgraber KH. Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils. Journal of Molecular Biology. 361: 932-44. PMID 16890957 DOI: 10.1016/j.jmb.2006.06.080 |
0.619 |
|
| 2006 |
Safar JG, Wille H, Geschwind MD, Deering C, Latawiec D, Serban A, King DJ, Legname G, Weisgraber KH, Mahley RW, Miller BL, Dearmond SJ, Prusiner SB. Human prions and plasma lipoproteins. Proceedings of the National Academy of Sciences of the United States of America. 103: 11312-7. PMID 16849426 DOI: 10.1073/Pnas.0604021103 |
0.384 |
|
| 2006 |
Hatters DM, Peters-Libeu CA, Weisgraber KH. Apolipoprotein E structure: insights into function. Trends in Biochemical Sciences. 31: 445-54. PMID 16820298 DOI: 10.1016/j.tibs.2006.06.008 |
0.458 |
|
| 2006 |
Mahley RW, Huang Y, Weisgraber KH. Putting cholesterol in its place: apoE and reverse cholesterol transport. The Journal of Clinical Investigation. 116: 1226-9. PMID 16670767 DOI: 10.1172/Jci28632 |
0.372 |
|
| 2006 |
Mahley RW, Weisgraber KH, Huang Y. Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 103: 5644-51. PMID 16567625 DOI: 10.1073/Pnas.0600549103 |
0.434 |
|
| 2006 |
Braun NA, Mohler PJ, Weisgraber KH, Hasty AH, Linton MF, Yancey PG, Su YR, Fazio S, Swift LL. Intracellular trafficking of recycling apolipoprotein E in Chinese hamster ovary cells. Journal of Lipid Research. 47: 1176-86. PMID 16534141 DOI: 10.1194/Jlr.M500503-Jlr200 |
0.409 |
|
| 2006 |
Peters-Libeu CA, Newhouse Y, Hatters DM, Weisgraber KH. Model of biologically active apolipoprotein E bound to dipalmitoylphosphatidylcholine. The Journal of Biological Chemistry. 281: 1073-9. PMID 16278220 DOI: 10.1074/jbc.M510851200 |
0.454 |
|
| 2005 |
Newhouse Y, Peters-Libeu C, Weisgraber KH. Crystallization and preliminary X-ray diffraction analysis of apolipoprotein E-containing lipoprotein particles. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 981-4. PMID 16511213 DOI: 10.1107/S1744309105032410 |
0.347 |
|
| 2005 |
Ye S, Huang Y, Müllendorff K, Dong L, Giedt G, Meng EC, Cohen FE, Kuntz ID, Weisgraber KH, Mahley RW. Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target. Proceedings of the National Academy of Sciences of the United States of America. 102: 18700-5. PMID 16344478 DOI: 10.1073/Pnas.0508693102 |
0.416 |
|
| 2005 |
Ramaswamy G, Xu Q, Huang Y, Weisgraber KH. Effect of domain interaction on apolipoprotein E levels in mouse brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10658-63. PMID 16291938 DOI: 10.1523/Jneurosci.1922-05.2005 |
0.426 |
|
| 2005 |
Hatters DM, Budamagunta MS, Voss JC, Weisgraber KH. Modulation of apolipoprotein E structure by domain interaction: differences in lipid-bound and lipid-free forms. The Journal of Biological Chemistry. 280: 34288-95. PMID 16076841 DOI: 10.1074/Jbc.M506044200 |
0.419 |
|
| 2005 |
Zhang S, Picard MH, Vasile E, Zhu Y, Raffai RL, Weisgraber KH, Krieger M. Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice. Circulation. 111: 3457-64. PMID 15967843 DOI: 10.1161/CIRCULATIONAHA.104.523563 |
0.33 |
|
| 2005 |
Hatters DM, Peters-Libeu CA, Weisgraber KH. Engineering conformational destabilization into mouse apolipoprotein E. A model for a unique property of human apolipoprotein E4. The Journal of Biological Chemistry. 280: 26477-82. PMID 15890642 DOI: 10.1074/jbc.M503910200 |
0.483 |
|
| 2005 |
Ruiz J, Kouiavskaia D, Migliorini M, Robinson S, Saenko EL, Gorlatova N, Li D, Lawrence D, Hyman BT, Weisgraber KH, Strickland DK. The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor. Journal of Lipid Research. 46: 1721-31. PMID 15863833 DOI: 10.1194/Jlr.M500114-Jlr200 |
0.403 |
|
| 2005 |
Hasty AH, Plummer MR, Weisgraber KH, Linton MF, Fazio S, Swift LL. The recycling of apolipoprotein E in macrophages: influence of HDL and apolipoprotein A-I. Journal of Lipid Research. 46: 1433-9. PMID 15805547 DOI: 10.1194/Jlr.M400418-Jlr200 |
0.43 |
|
| 2005 |
Sauer I, Dunay IR, Weisgraber K, Bienert M, Dathe M. An apolipoprotein E-derived peptide mediates uptake of sterically stabilized liposomes into brain capillary endothelial cells Biochemistry. 44: 2021-2029. PMID 15697227 DOI: 10.1021/bi048080x |
0.332 |
|
| 2005 |
Zhao Y, Thorngate FE, Weisgraber KH, Williams DL, Parks JS. Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins. Biochemistry. 44: 1013-25. PMID 15654758 DOI: 10.1021/bi0481489 |
0.436 |
|
| 2005 |
Raffai RL, Loeb SM, Weisgraber KH. Apolipoprotein E promotes the regression of atherosclerosis independently of lowering plasma cholesterol levels. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 436-41. PMID 15591220 DOI: 10.1161/01.ATV.0000152613.83243.12 |
0.43 |
|
| 2004 |
Huang Y, Weisgraber KH, Mucke L, Mahley RW. Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease. Journal of Molecular Neuroscience : Mn. 23: 189-204. PMID 15181247 DOI: 10.1385/Jmn:23:3:189 |
0.414 |
|
| 2004 |
Farkas MH, Weisgraber KH, Shepherd VL, Linton MF, Fazio S, Swift LL. The recycling of apolipoprotein E and its amino-terminal 22 kDa fragment: evidence for multiple redundant pathways. Journal of Lipid Research. 45: 1546-54. PMID 15145976 DOI: 10.1194/Jlr.M400104-Jlr200 |
0.479 |
|
| 2004 |
Xu Q, Brecht WJ, Weisgraber KH, Mahley RW, Huang Y. Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer. The Journal of Biological Chemistry. 279: 25511-6. PMID 15054100 DOI: 10.1074/Jbc.M311256200 |
0.393 |
|
| 2003 |
Harris FM, Brecht WJ, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, Fish JD, Masliah E, Hopkins PC, Scearce-Levie K, Weisgraber KH, Mucke L, Mahley RW, Huang Y. Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 10966-71. PMID 12939405 DOI: 10.1073/Pnas.1434398100 |
0.404 |
|
| 2003 |
Raffaï RL, McPherson R, Weisgraber KH, Innerarity TL, Rassart E, Bersot TP, Milne RW. Antibody phenotyping test for the human apolipoprotein E2 isoform. Clinical Chemistry. 49: 1524-6. PMID 12928236 DOI: 10.1373/49.9.1524 |
0.421 |
|
| 2003 |
Saito H, Dhanasekaran P, Baldwin F, Weisgraber KH, Phillips MC, Lund-Katz S. Effects of polymorphism on the lipid interaction of human apolipoprotein E. The Journal of Biological Chemistry. 278: 40723-9. PMID 12917433 DOI: 10.1074/jbc.M304814200 |
0.448 |
|
| 2003 |
Raffai RL, Weisgraber KH. Cholesterol: from heart attacks to Alzheimer's disease. Journal of Lipid Research. 44: 1423-30. PMID 12837845 DOI: 10.1194/jlr.R300007-JLR200 |
0.341 |
|
| 2003 |
Kasravi FB, Welch WJ, Peters-Lideu CA, Weisgraber KH, Harris HW. Induction of cytokine tolerance in rodent hepatocytes by chylomicron-bound LPS is low-density lipoprotein receptor dependent. Shock (Augusta, Ga.). 19: 157-62. PMID 12578125 DOI: 10.1097/00024382-200302000-00012 |
0.317 |
|
| 2003 |
Raffaï RL, Hasty AH, Wang Y, Mettler SE, Sanan DA, Linton MF, Fazio S, Weisgraber KH. Hepatocyte-derived ApoE is more effective than non-hepatocyte-derived ApoE in remnant lipoprotein clearance. The Journal of Biological Chemistry. 278: 11670-5. PMID 12551940 DOI: 10.1074/Jbc.M212873200 |
0.388 |
|
| 2002 |
Morrow JA, Hatters DM, Lu B, Hochtl P, Oberg KA, Rupp B, Weisgraber KH. Apolipoprotein E4 forms a molten globule. A potential basis for its association with disease. The Journal of Biological Chemistry. 277: 50380-5. PMID 12393895 DOI: 10.1074/jbc.M204898200 |
0.377 |
|
| 2002 |
Segall ML, Dhanasekaran P, Baldwin F, Anantharamaiah GM, Weisgraber KH, Phillips MC, Lund-Katz S. Influence of apoE domain structure and polymorphism on the kinetics of phospholipid vesicle solubilization. Journal of Lipid Research. 43: 1688-700. PMID 12364553 DOI: 10.1194/Jlr.M200157-Jlr200 |
0.407 |
|
| 2002 |
Zeleny M, Swertfeger DK, Weisgraber KH, Hui DY. Distinct apolipoprotein E isoform preference for inhibition of smooth muscle cell migration and proliferation. Biochemistry. 41: 11820-3. PMID 12269825 DOI: 10.1021/bi026202k |
0.301 |
|
| 2002 |
Acharya P, Segall ML, Zaiou M, Morrow J, Weisgraber KH, Phillips MC, Lund-Katz S, Snow J. Comparison of the stabilities and unfolding pathways of human apolipoprotein E isoforms by differential scanning calorimetry and circular dichroism. Biochimica Et Biophysica Acta. 1584: 9-19. PMID 12213488 DOI: 10.1016/S1388-1981(02)00263-9 |
0.418 |
|
| 2002 |
Ji ZS, Miranda RD, Newhouse YM, Weisgraber KH, Huang Y, Mahley RW. Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells. The Journal of Biological Chemistry. 277: 21821-8. PMID 11912196 DOI: 10.1074/Jbc.M112109200 |
0.345 |
|
| 2002 |
Raffai RL, Weisgraber KH. Hypomorphic apolipoprotein E mice: a new model of conditional gene repair to examine apolipoprotein E-mediated metabolism. The Journal of Biological Chemistry. 277: 11064-8. PMID 11792702 DOI: 10.1074/jbc.M111222200 |
0.382 |
|
| 2001 |
Raffai RL, Dong LM, Farese RV, Weisgraber KH. Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E. Proceedings of the National Academy of Sciences of the United States of America. 98: 11587-91. PMID 11553788 DOI: 10.1073/pnas.201279298 |
0.499 |
|
| 2001 |
Saito H, Dhanasekaran P, Baldwin F, Weisgraber KH, Lund-Katz S, Phillips MC. Lipid binding-induced conformational change in human apolipoprotein E. Evidence for two lipid-bound states on spherical particles. The Journal of Biological Chemistry. 276: 40949-54. PMID 11533033 DOI: 10.1074/jbc.M106337200 |
0.309 |
|
| 2001 |
Dong J, Peters-Libeu CA, Weisgraber KH, Segelke BW, Rupp B, Capila I, Hernáiz MJ, LeBrun LA, Linhardt RJ. Interaction of the N-terminal domain of apolipoprotein E4 with heparin. Biochemistry. 40: 2826-34. PMID 11258893 DOI: 10.1021/Bi002417N |
0.401 |
|
| 2000 |
Dong J, Balestra ME, Newhouse YM, Weisgraber KH. Human apolipoprotein E7:lysine mutations in the carboxy-terminal domain are directly responsible for preferential binding to very low density lipoproteins. Journal of Lipid Research. 41: 1783-9. PMID 11060347 |
0.368 |
|
| 2000 |
Morrow JA, Segall ML, Lund-Katz S, Phillips MC, Knapp M, Rupp B, Weisgraber KH. Differences in stability among the human apolipoprotein E isoforms determined by the amino-terminal domain. Biochemistry. 39: 11657-66. PMID 10995233 DOI: 10.1021/bi000099m |
0.422 |
|
| 2000 |
Lund-Katz S, Zaiou M, Wehrli S, Dhanasekaran P, Baldwin F, Weisgraber KH, Phillips MC. Effects of lipid interaction on the lysine microenvironments in apolipoprotein E. The Journal of Biological Chemistry. 275: 34459-64. PMID 10921925 DOI: 10.1074/jbc.M005265200 |
0.316 |
|
| 2000 |
Segelke BW, Forstner M, Knapp M, Trakhanov SD, Parkin S, Newhouse YM, Bellamy HD, Weisgraber KH, Rupp B. Conformational flexibility in the apolipoprotein E amino-terminal domain structure determined from three new crystal forms: implications for lipid binding. Protein Science : a Publication of the Protein Society. 9: 886-97. PMID 10850798 DOI: 10.1110/ps.9.5.886 |
0.378 |
|
| 2000 |
Lu B, Morrow JA, Weisgraber KH. Conformational reorganization of the four-helix bundle of human apolipoprotein E in binding to phospholipid. The Journal of Biological Chemistry. 275: 20775-81. PMID 10801877 DOI: 10.1074/jbc.M003508200 |
0.393 |
|
| 2000 |
Klezovitch O, Formato M, Cherchi GM, Weisgraber KH, Scanu AM. Structural determinants in the C-terminal domain of apolipoprotein E mediating binding to the protein core of human aortic biglycan. The Journal of Biological Chemistry. 275: 18913-8. PMID 10751422 DOI: 10.1074/jbc.M909644199 |
0.441 |
|
| 2000 |
Raffaï R, Weisgraber KH, MacKenzie R, Rupp B, Rassart E, Hirama T, Innerarity TL, Milne R. Binding of an antibody mimetic of the human low density lipoprotein receptor to apolipoprotein E is governed through electrostatic forces. Studies using site-directed mutagenesis and molecular modeling. The Journal of Biological Chemistry. 275: 7109-16. PMID 10702278 DOI: 10.1074/jbc.275.10.7109 |
0.462 |
|
| 2000 |
Morrow JA, Arnold KS, Dong J, Balestra ME, Innerarity TL, Weisgraber KH. Effect of arginine 172 on the binding of apolipoprotein E to the low density lipoprotein receptor. The Journal of Biological Chemistry. 275: 2576-80. PMID 10644716 DOI: 10.1074/jbc.275.4.2576 |
0.406 |
|
| 1999 |
Forstner M, Peters-Libeu C, Contreras-Forrest E, Newhouse Y, Knapp M, Rupp B, Weisgraber KH. Carboxyl-terminal domain of human apolipoprotein E: expression, purification, and crystallization. Protein Expression and Purification. 17: 267-72. PMID 10545275 DOI: 10.1006/prep.1999.1144 |
0.42 |
|
| 1999 |
Rozek A, Sparrow JT, Weisgraber KH, Cushley RJ. Conformation of human apolipoprotein C-I in a lipid-mimetic environment determined by CD and NMR spectroscopy. Biochemistry. 38: 14475-84. PMID 10545169 DOI: 10.1021/Bi982966H |
0.36 |
|
| 1999 |
Morrow JA, Arnold KS, Weisgraber KH. Functional characterization of apolipoprotein E isoforms overexpressed in Escherichia coli. Protein Expression and Purification. 16: 224-30. PMID 10419818 DOI: 10.1006/prep.1999.1069 |
0.499 |
|
| 1999 |
Raffaï R, Vukmirica J, Weisgraber KH, Rassart E, Innerarity TL, Milne R. Bacterial expression and purification of the Fab fragment of a monoclonal antibody specific for the low-density lipoprotein receptor-binding site of human apolipoprotein E. Protein Expression and Purification. 16: 84-90. PMID 10336864 DOI: 10.1006/Prep.1999.1031 |
0.413 |
|
| 1999 |
Orth M, Weng W, Funke H, Steinmetz A, Assmann G, Nauck M, Dierkes J, Ambrosch A, Weisgraber KH, Mahley RW, Wieland H, Luley C. Effects of a frequent apolipoprotein E isoform, ApoE4Freiburg (Leu28-->Pro), on lipoproteins and the prevalence of coronary artery disease in whites. Arteriosclerosis, Thrombosis, and Vascular Biology. 19: 1306-15. PMID 10323784 DOI: 10.1161/01.Atv.19.5.1306 |
0.431 |
|
| 1999 |
Trakhanov S, Parkin S, Raffaï R, Milne R, Newhouse YM, Weisgraber KH, Rupp B. Structure of a monoclonal 2E8 Fab antibody fragment specific for the low-density lipoprotein-receptor binding region of apolipoprotein E refined at 1.9 A. Acta Crystallographica. Section D, Biological Crystallography. 55: 122-8. PMID 10089402 DOI: 10.1107/S090744499800938X |
0.444 |
|
| 1999 |
Gillotte KL, Zaiou M, Lund-Katz S, Anantharamaiah GM, Holvoet P, Dhoest A, Palgunachari MN, Segrest JP, Weisgraber KH, Rothblat GH, Phillips MC. Apolipoprotein-mediated plasma membrane microsolubilization. Role of lipid affinity and membrane penetration in the efflux of cellular cholesterol and phospholipid. The Journal of Biological Chemistry. 274: 2021-8. PMID 9890960 DOI: 10.1074/Jbc.274.4.2021 |
0.435 |
|
| 1998 |
Pitas RE, Ji ZS, Weisgraber KH, Mahley RW. Role of apolipoprotein E in modulating neurite outgrowth: potential effect of intracellular apolipoprotein E. Biochemical Society Transactions. 26: 257-62. PMID 9649758 DOI: 10.1042/Bst0260257 |
0.374 |
|
| 1998 |
Dong LM, Innerarity TL, Arnold KS, Newhouse YM, Weisgraber KH. The carboxyl terminus in apolipoprotein E2 and the seven amino acid repeat in apolipoprotein E-Leiden: role in receptor-binding activity. Journal of Lipid Research. 39: 1173-80. PMID 9643348 |
0.306 |
|
| 1998 |
Dichek HL, Brecht W, Fan J, Ji ZS, McCormick SP, Akeefe H, Conzo L, Sanan DA, Weisgraber KH, Young SG, Taylor JM, Mahley RW. Overexpression of hepatic lipase in transgenic mice decreases apolipoprotein B-containing and high density lipoproteins. Evidence that hepatic lipase acts as a ligand for lipoprotein uptake. The Journal of Biological Chemistry. 273: 1896-903. PMID 9442022 DOI: 10.1074/jbc.273.4.1896 |
0.397 |
|
| 1997 |
Grunfeld C, Doerrler W, Pang M, Jensen P, Weisgraber KH, Feingold KR. Abnormalities of apolipoprotein E in the acquired immunodeficiency syndrome. The Journal of Clinical Endocrinology and Metabolism. 82: 3734-40. PMID 9360533 DOI: 10.1210/Jcem.82.11.4366 |
0.397 |
|
| 1997 |
Simmons T, Newhouse YM, Arnold KS, Innerarity TL, Weisgraber KH. Human low density lipoprotein receptor fragment. Successful refolding of a functionally active ligand-binding domain produced in Escherichia coli. The Journal of Biological Chemistry. 272: 25531-6. PMID 9325268 DOI: 10.1074/jbc.272.41.25531 |
0.403 |
|
| 1997 |
Gutman CR, Strittmatter WJ, Weisgraber KH, Matthew WD. Apolipoprotein E binds to and potentiates the biological activity of ciliary neurotrophic factor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 6114-21. PMID 9236223 DOI: 10.1523/Jneurosci.17-16-06114.1997 |
0.384 |
|
| 1996 |
Weisgraber KH, Mahley RW. Human apolipoprotein E: the Alzheimer's disease connection. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 10: 1485-94. PMID 8940294 DOI: 10.1096/Fasebj.10.13.8940294 |
0.43 |
|
| 1996 |
Montine TJ, Huang DY, Valentine WM, Amarnath V, Saunders A, Weisgraber KH, Graham DG, Strittmatter WJ. Crosslinking of apolipoprotein E by products of lipid peroxidation. Journal of Neuropathology and Experimental Neurology. 55: 202-10. PMID 8786379 DOI: 10.1097/00005072-199602000-00009 |
0.442 |
|
| 1996 |
Dong LM, Parkin S, Trakhanov SD, Rupp B, Simmons T, Arnold KS, Newhouse YM, Innerarity TL, Weisgraber KH. Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemia. Nature Structural Biology. 3: 718-22. PMID 8756331 DOI: 10.1038/Nsb0896-718 |
0.359 |
|
| 1996 |
Dong LM, Weisgraber KH. Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins. The Journal of Biological Chemistry. 271: 19053-7. PMID 8702576 DOI: 10.1074/jbc.271.32.19053 |
0.426 |
|
| 1996 |
Roses AD, Einstein G, Gilbert J, Goedert M, Han SH, Huang D, Hulette C, Masliah E, Pericak-Vance MA, Saunders AM, Schmechel DE, Strittmatter WJ, Weisgraber KH, Xi PT. Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism. Annals of the New York Academy of Sciences. 777: 146-57. PMID 8624078 DOI: 10.1111/J.1749-6632.1996.Tb34413.X |
0.446 |
|
| 1996 |
Fleming LM, Weisgraber KH, Strittmatter WJ, Troncoso JC, Johnson GV. Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins. Experimental Neurology. 138: 252-60. PMID 8620924 DOI: 10.1006/Exnr.1996.0064 |
0.407 |
|
| 1995 |
Evans KC, Berger EP, Cho CG, Weisgraber KH, Lansbury PT. Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 92: 763-7. PMID 7846048 DOI: 10.1073/Pnas.92.3.763 |
0.388 |
|
| 1995 |
Minnich A, Weisgraber KH, Newhouse Y, Dong LM, Fortin LJ, Tremblay M, Davignon J. Identification and characterization of a novel apolipoprotein E variant, apolipoprotein E3' (Arg136-->His): association with mild dyslipidemia and double pre-beta very low density lipoproteins. Journal of Lipid Research. 36: 57-66. PMID 7706948 |
0.358 |
|
| 1995 |
Saxena U, Auerbach BJ, Ferguson E, Wölle J, Marcel YL, Weisgraber KH, Hegele RA, Bisgaier CL. Apolipoprotein B and E basic amino acid clusters influence low-density lipoprotein association with lipoprotein lipase anchored to the subendothelial matrix. Arteriosclerosis, Thrombosis, and Vascular Biology. 15: 1240-7. PMID 7627718 DOI: 10.1161/01.Atv.15.8.1240 |
0.437 |
|
| 1995 |
Huang DY, Weisgraber KH, Goedert M, Saunders AM, Roses AD, Strittmatter WJ. ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation. Neuroscience Letters. 192: 209-12. PMID 7566652 DOI: 10.1016/0304-3940(95)11649-H |
0.383 |
|
| 1995 |
Huang DY, Weisgraber KH, Strittmatter WJ, Matthew WD. Interaction of apolipoprotein E with laminin increases neuronal adhesion and alters neurite morphology. Experimental Neurology. 136: 251-7. PMID 7498414 DOI: 10.1006/Exnr.1995.1101 |
0.352 |
|
| 1994 |
Nathan BP, Bellosta S, Sanan DA, Weisgraber KH, Mahley RW, Pitas RE. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science (New York, N.Y.). 264: 850-2. PMID 8171342 DOI: 10.1126/Science.8171342 |
0.431 |
|
| 1994 |
Weisgraber KH. Apolipoprotein E: structure-function relationships. Advances in Protein Chemistry. 45: 249-302. PMID 8154371 DOI: 10.1016/S0065-3233(08)60642-7 |
0.453 |
|
| 1994 |
Weisgraber KH, Newhouse YM, McPherson A. Crystallization and preliminary X-ray analysis of human plasma apolipoprotein C-I. Journal of Molecular Biology. 236: 382-4. PMID 8107122 DOI: 10.1006/Jmbi.1994.1146 |
0.301 |
|
| 1994 |
Han SH, Einstein G, Weisgraber KH, Strittmatter WJ, Saunders AM, Pericak-Vance M, Roses AD, Schmechel DE. Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study. Journal of Neuropathology and Experimental Neurology. 53: 535-44. PMID 8083695 DOI: 10.1097/00005072-199409000-00013 |
0.37 |
|
| 1994 |
Dong LM, Wilson C, Wardell MR, Simmons T, Mahley RW, Weisgraber KH, Agard DA. Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms. The Journal of Biological Chemistry. 269: 22358-65. PMID 8071364 DOI: 10.2210/Pdb1Le4/Pdb |
0.456 |
|
| 1994 |
Weisgraber KH, Roses AD, Strittmatter WJ. The role of apolipoprotein E in the nervous system. Current Opinion in Lipidology. 5: 110-6. PMID 8044413 DOI: 10.1097/00041433-199404000-00007 |
0.445 |
|
| 1994 |
Fazio S, Horie Y, Simonet WS, Weisgraber KH, Taylor JM, Rall SC. Altered lipoprotein metabolism in transgenic mice expressing low levels of a human receptor-binding-defective apolipoprotein E variant. Journal of Lipid Research. 35: 408-16. PMID 8014576 |
0.342 |
|
| 1994 |
Wilson C, Mau T, Weisgraber KH, Wardell MR, Mahley RW, Agard DA. Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein. Structure (London, England : 1993). 2: 713-8. PMID 7994571 DOI: 10.1016/S0969-2126(00)00072-1 |
0.476 |
|
| 1994 |
Strittmatter WJ, Saunders AM, Goedert M, Weisgraber KH, Dong LM, Jakes R, Huang DY, Pericak-Vance M, Schmechel D, Roses AD. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 91: 11183-6. PMID 7972031 DOI: 10.1073/Pnas.91.23.11183 |
0.421 |
|
| 1994 |
Huang DY, Goedert M, Jakes R, Weisgraber KH, Garner CC, Saunders AM, Pericak-Vance MA, Schmechel DE, Roses AD, Strittmatter WJ. Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease. Neuroscience Letters. 182: 55-8. PMID 7891887 DOI: 10.1016/0304-3940(94)90204-6 |
0.413 |
|
| 1994 |
Weisgraber KH, Pitas RE, Mahley RW. Lipoproteins, neurobiology, and Alzheimer's disease: Structure and function of apolipoprotein E Current Opinion in Structural Biology. 4: 507-515. DOI: 10.1016/S0959-440X(94)90212-7 |
0.455 |
|
| 1994 |
Roses A, Saunders A, Corder E, Risch N, Haines J, Pericak-Vance M, Han S, Einstein G, Hulette C, Schmechel D, Goedert M, Jakes R, Dong L, Weisgraber K, Holsti M, et al. Apolipoprotein E-e4 and apolipoprotein E-e2 are susceptibility genes that affect the rate of disease expressivity of late-onset familial and sporadic Alzheimer disease Journal of the Neurological Sciences. 127: 2. DOI: 10.1016/0022-510X(94)90109-0 |
0.373 |
|
| 1994 |
Saxena U, Auerbach B, Ferguson E, Woelle J, Marcel Y, Weisgraber K, Bisgaier C. Effects of apo E on the LPL-mediated retention of apo B containing lipoproteins by arterial matrix Atherosclerosis. 109: 260-261. DOI: 10.1016/0021-9150(94)94041-X |
0.389 |
|
| 1993 |
Fazio S, Horie Y, Weisgraber KH, Havekes LM, Rall SC. Preferential association of apolipoprotein E Leiden with very low density lipoproteins of human plasma. Journal of Lipid Research. 34: 447-53. PMID 8468528 |
0.341 |
|
| 1993 |
Schmidt EB, Illingworth DR, Bacon S, Mahley RW, Weisgraber KH. Hypocholesterolemic effects of cholestyramine and colestipol in patients with familial defective apolipoprotein B-100. Atherosclerosis. 98: 213-7. PMID 8457260 DOI: 10.1016/0021-9150(93)90130-M |
0.327 |
|
| 1993 |
Strittmatter WJ, Weisgraber KH, Huang DY, Dong LM, Salvesen GS, Pericak-Vance M, Schmechel D, Saunders AM, Goldgaber D, Roses AD. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 90: 8098-102. PMID 8367470 DOI: 10.1073/Pnas.90.17.8098 |
0.336 |
|
| 1993 |
de Silva HV, Lauer SJ, Mahley RW, Weisgraber KH, Taylor JM. Apolipoproteins E and C-III have opposing roles in the clearance of lipoprotein remnants in transgenic mice. Biochemical Society Transactions. 21: 483-7. PMID 8359515 DOI: 10.1042/Bst0210483 |
0.371 |
|
| 1993 |
Westerlund JA, Weisgraber KH. Discrete carboxyl-terminal segments of apolipoprotein E mediate lipoprotein association and protein oligomerization. The Journal of Biological Chemistry. 268: 15745-50. PMID 8340399 |
0.347 |
|
| 1993 |
Lund-Katz S, Weisgraber KH, Mahley RW, Phillips MC. Conformation of apolipoprotein E in lipoproteins. The Journal of Biological Chemistry. 268: 23008-15. PMID 8226815 |
0.336 |
|
| 1992 |
Horie Y, Fazio S, Westerlund JR, Weisgraber KH, Rall SC. The functional characteristics of a human apolipoprotein E variant (cysteine at residue 142) may explain its association with dominant expression of type III hyperlipoproteinemia. The Journal of Biological Chemistry. 267: 1962-8. PMID 1730728 |
0.344 |
|
| 1992 |
Thuren T, Weisgraber KH, Sisson P, Waite M. Role of apolipoprotein E in hepatic lipase catalyzed hydrolysis of phospholipid in high-density lipoproteins. Biochemistry. 31: 2332-8. PMID 1540589 DOI: 10.1021/Bi00123A018 |
0.438 |
|
| 1992 |
Handelmann GE, Boyles JK, Weisgraber KH, Mahley RW, Pitas RE. Effects of apolipoprotein E, beta-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro. Journal of Lipid Research. 33: 1677-88. PMID 1464751 |
0.332 |
|
| 1992 |
Illingworth DR, Vakar F, Mahley RW, Weisgraber KH. Hypocholesterolaemic effects of lovastatin in familial defective apolipoprotein B-100. Lancet. 339: 598-600. PMID 1347103 DOI: 10.1016/0140-6736(92)90875-4 |
0.326 |
|
| 1991 |
Wilson C, Wardell MR, Weisgraber KH, Mahley RW, Agard DA. Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E. Science (New York, N.Y.). 252: 1817-22. PMID 2063194 DOI: 10.1126/Science.2063194 |
0.452 |
|
| 1991 |
Weisgraber KH, Shinto LH. Identification of the disulfide-linked homodimer of apolipoprotein E3 in plasma. Impact on receptor binding activity. The Journal of Biological Chemistry. 266: 12029-34. PMID 2050696 |
0.313 |
|
| 1991 |
Mahley RW, Weisgraber KH, Innerarity TL, Rall SC. Genetic defects in lipoprotein metabolism. Elevation of atherogenic lipoproteins caused by impaired catabolism. Jama. 265: 78-83. PMID 1845776 DOI: 10.1001/jama.1991.03460010078035 |
0.43 |
|
| 1991 |
Wardell MR, Rall SC, Schaefer EJ, Kane JP, Weisgraber KH. Two apolipoprotein E5 variants illustrate the importance of the position of additional positive charge on receptor-binding activity. Journal of Lipid Research. 32: 521-8. PMID 1648586 |
0.306 |
|
| 1990 |
Kowal RC, Herz J, Weisgraber KH, Mahley RW, Brown MS, Goldstein JL. Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein. The Journal of Biological Chemistry. 265: 10771-9. PMID 2355022 |
0.353 |
|
| 1990 |
Wardell MR, Rall SC, Brennan SO, Nye ER, George PM, Janus ED, Weisgraber KH. Apolipoprotein E2-Dunedin (228 Arg replaced by Cys): an apolipoprotein E2 variant with normal receptor-binding activity. Journal of Lipid Research. 31: 535-43. PMID 2341812 |
0.366 |
|
| 1990 |
Weisgraber KH. Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112. Journal of Lipid Research. 31: 1503-11. PMID 2280190 |
0.348 |
|
| 1990 |
Weisgraber KH, Innerarity TL, Rall SC, Mahley RW. Atherogenic lipoproteins resulting from genetic defects of apolipoproteins B and E. Annals of the New York Academy of Sciences. 598: 37-48. PMID 2248450 DOI: 10.1111/J.1749-6632.1990.Tb42274.X |
0.402 |
|
| 1990 |
Crook D, Weisgraber KH, Boyles JK, Mahley RW. Isolation and characterization of plasma lipoproteins of common marmoset monkey. Comparison of effects of control and atherogenic diets. Arteriosclerosis (Dallas, Tex.). 10: 633-47. PMID 2114868 DOI: 10.1161/01.Atv.10.4.633 |
0.389 |
|
| 1990 |
Crook D, Weisgraber KH, Rall SC, Mahley RW. Isolation and characterization of several plasma apolipoproteins of common marmoset monkey. Arteriosclerosis (Dallas, Tex.). 10: 625-32. PMID 2114867 DOI: 10.1161/01.Atv.10.4.625 |
0.378 |
|
| 1989 |
Weisgraber KH, Newhouse YM, Taylor JM, Tuan B, Nestruck AC, Davignon J, Mahley RW. Apolipoprotein E2(Arg158----Cys) frequency in a hyperlipidemic French-Canadian population of apolipoprotein E2/2 subjects. Determination by synthetic oligonucleotide probes. Arteriosclerosis (Dallas, Tex.). 9: 50-7. PMID 2912421 DOI: 10.1161/01.Atv.9.1.50 |
0.44 |
|
| 1989 |
Mahley RW, Weisgraber KH, Hussain MM, Greenman B, Fisher M, Vogel T, Gorecki M. Intravenous infusion of apolipoprotein E accelerates clearance of plasma lipoproteins in rabbits. The Journal of Clinical Investigation. 83: 2125-30. PMID 2723074 DOI: 10.1172/JCI114126 |
0.312 |
|
| 1989 |
Gong EL, Nichols AV, Weisgraber KH, Forte TM, Shore VG, Blanche PJ. Discoidal complexes containing apolipoprotein E and their transformation by lecithin-cholesterol acyltransferase. Biochimica Et Biophysica Acta. 1006: 317-28. PMID 2597674 DOI: 10.1016/0005-2760(89)90019-2 |
0.391 |
|
| 1989 |
Wardell MR, Weisgraber KH, Havekes LM, Rall SC. Apolipoprotein E3-Leiden contains a seven-amino acid insertion that is a tandem repeat of residues 121-127. The Journal of Biological Chemistry. 264: 21205-10. PMID 2556398 |
0.323 |
|
| 1989 |
Rall SC, Newhouse YM, Clarke HR, Weisgraber KH, McCarthy BJ, Mahley RW, Bersot TP. Type III hyperlipoproteinemia associated with apolipoprotein E phenotype E3/3. Structure and genetics of an apolipoprotein E3 variant. The Journal of Clinical Investigation. 83: 1095-101. PMID 2539388 DOI: 10.1172/JCI113988 |
0.416 |
|
| 1988 |
Weisgraber KH, Newhouse YM, Mahley RW. Apolipoprotein E genotyping using the polymerase chain reaction and allele-specific oligonucleotide probes. Biochemical and Biophysical Research Communications. 157: 1212-7. PMID 3207421 DOI: 10.1016/S0006-291X(88)81003-9 |
0.326 |
|
| 1988 |
Weisgraber KH, Innerarity TL, Newhouse YM, Young SG, Arnold KS, Krauss RM, Vega GL, Grundy SM, Mahley RW. Familial defective apolipoprotein B-100: enhanced binding of monoclonal antibody MB47 to abnormal low density lipoproteins. Proceedings of the National Academy of Sciences of the United States of America. 85: 9758-62. PMID 3200853 DOI: 10.1073/Pnas.85.24.9758 |
0.371 |
|
| 1988 |
Aggerbeck LP, Wetterau JR, Weisgraber KH, Mahley RW, Agard DA. Crystallization and preliminary X-ray diffraction studies on the amino-terminal (receptor-binding) domain of human apolipoprotein E3 from serum very low density lipoproteins. Journal of Molecular Biology. 202: 179-81. PMID 3172212 DOI: 10.1016/0022-2836(88)90531-1 |
0.45 |
|
| 1988 |
Majack RA, Castle CK, Goodman LV, Weisgraber KH, Mahley RW, Shooter EM, Gebicke-Haerter PJ. Expression of apolipoprotein E by cultured vascular smooth muscle cells is controlled by growth state. The Journal of Cell Biology. 107: 1207-13. PMID 2458361 |
0.303 |
|
| 1987 |
Innerarity TL, Weisgraber KH, Arnold KS, Mahley RW, Krauss RM, Vega GL, Grundy SM. Familial defective apolipoprotein B-100: low density lipoproteins with abnormal receptor binding. Proceedings of the National Academy of Sciences of the United States of America. 84: 6919-23. PMID 3477815 DOI: 10.1073/Pnas.84.19.6919 |
0.389 |
|
| 1987 |
Pitas RE, Boyles JK, Lee SH, Hui D, Weisgraber KH. Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain. The Journal of Biological Chemistry. 262: 14352-60. PMID 3115992 |
0.336 |
|
| 1987 |
Gebicke-Haerter PJ, Darby JK, Shooter EM, Riccardi VM, Weisgraber KH, Boyles JK, Mahley RW. Apolipoprotein E synthesis in neurofibrosarcoma and schwannoma cell cultures from two individuals with neurofibromatosis. Experimental Neurology. 95: 323-35. PMID 3100319 DOI: 10.1016/0014-4886(87)90142-7 |
0.348 |
|
| 1987 |
Innerarity TL, Weisgraber KH, Rall SC, Mahley RW. Functional domains of apolipoprotein E and apolipoprotein B. Acta Medica Scandinavica. Supplementum. 715: 51-9. PMID 3035881 DOI: 10.1111/J.0954-6820.1987.Tb09903.X |
0.385 |
|
| 1986 |
Weisgraber KH, Mahley RW. Characterization of apolipoprotein E-containing lipoproteins. Methods in Enzymology. 129: 145-66. PMID 3724537 DOI: 10.1016/0076-6879(86)29067-9 |
0.421 |
|
| 1986 |
Rall SC, Weisgraber KH, Mahley RW. Isolation and characterization of apolipoprotein E. Methods in Enzymology. 128: 273-87. PMID 3724506 DOI: 10.1016/0076-6879(86)28073-8 |
0.381 |
|
| 1986 |
Bersot TP, Innerarity TL, Pitas RE, Rall SC, Weisgraber KH, Mahley RW. Fat feeding in humans induces lipoproteins of density less than 1.006 that are enriched in apolipoprotein [a] and that cause lipid accumulation in macrophages. The Journal of Clinical Investigation. 77: 622-30. PMID 2935560 DOI: 10.1172/JCI112345 |
0.325 |
|
| 1985 |
Vogel T, Weisgraber KH, Zeevi MI, Ben-Artzi H, Levanon AZ, Rall SC, Innerarity TL, Hui DY, Taylor JM, Kanner D. Human apolipoprotein E expression in Escherichia coli: structural and functional identity of the bacterially produced protein with plasma apolipoprotein E. Proceedings of the National Academy of Sciences of the United States of America. 82: 8696-700. PMID 3909150 |
0.352 |
|
| 1985 |
Mahley RW, Innerarity TL, Rall SC, Weisgraber KH. Lipoproteins of special significance in atherosclerosis. Insights provided by studies of type III hyperlipoproteinemia. Annals of the New York Academy of Sciences. 454: 209-21. PMID 3000263 DOI: 10.1111/j.1749-6632.1985.tb11860.x |
0.463 |
|
| 1985 |
Weisgraber KH, Innerarity TL, Rall SC, Mahley RW. Receptor interactions controlling lipoprotein metabolism. Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire. 63: 898-905. PMID 2998579 DOI: 10.1139/o85-111 |
0.356 |
|
| 1985 |
Weisgraber KH, Innerarity TL, Rall SC, Mahley RW. Apolipoprotein E: receptor binding properties. Advances in Experimental Medicine and Biology. 183: 159-71. PMID 2412412 |
0.34 |
|
| 1984 |
Utermann G, Haas J, Steinmetz A, Paetzold R, Rall SC, Weisgraber KH, Mahley RW. Apolipoprotein A-IGiessen (Pro143----Arg). A mutant that is defective in activating lecithin:cholesterol acyltransferase. European Journal of Biochemistry / Febs. 144: 325-31. PMID 6489332 DOI: 10.1111/J.1432-1033.1984.TB08467.X |
0.373 |
|
| 1984 |
Rall SC, Weisgraber KH, Mahley RW, Ogawa Y, Fielding CJ, Utermann G, Haas J, Steinmetz A, Menzel HJ, Assmann G. Abnormal lecithin:cholesterol acyltransferase activation by a human apolipoprotein A-I variant in which a single lysine residue is deleted. The Journal of Biological Chemistry. 259: 10063-70. PMID 6432779 |
0.329 |
|
| 1984 |
Innerarity TL, Weisgraber KH, Arnold KS, Rall SC, Mahley RW. Normalization of receptor binding of apolipoprotein E2. Evidence for modulation of the binding site conformation. The Journal of Biological Chemistry. 259: 7261-7. PMID 6327714 |
0.334 |
|
| 1984 |
Weisgraber KH, Rall SC, Innerarity TL, Mahley RW, Kuusi T, Ehnholm C. A novel electrophoretic variant of human apolipoprotein E. Identification and characterization of apolipoprotein E1. The Journal of Clinical Investigation. 73: 1024-33. PMID 6323533 DOI: 10.1172/JCI111287 |
0.322 |
|
| 1984 |
Innerarity TL, Bersot TP, Arnold KS, Weisgraber KH, Davis PA, Forte TM, Mahley RW. Receptor binding activity of high-density lipoproteins containing apoprotein E from abetalipoproteinemic and normal neonate plasma. Metabolism: Clinical and Experimental. 33: 186-95. PMID 6319954 DOI: 10.1016/0026-0495(84)90133-1 |
0.356 |
|
| 1984 |
Funke H, Boyles J, Weisgraber KH, Ludwig EH, Hui DY, Mahley RW. Uptake of apolipoprotein E-containing high density lipoproteins by hepatic parenchymal cells. Arteriosclerosis (Dallas, Tex.). 4: 452-61. PMID 6089725 |
0.322 |
|
| 1983 |
Rall SC, Weisgraber KH, Innerarity TL, Bersot TP, Mahley RW, Blum CB. Identification of a new structural variant of human apolipoprotein E, E2(Lys146 leads to Gln), in a type III hyperlipoproteinemic subject with the E3/2 phenotype. The Journal of Clinical Investigation. 72: 1288-97. PMID 6313758 DOI: 10.1172/JCI111085 |
0.416 |
|
| 1983 |
Weisgraber KH, Innerarity TL, Harder KJ, Mahley RW, Milne RW, Marcel YL, Sparrow JT. The receptor-binding domain of human apolipoprotein E. Monoclonal antibody inhibition of binding. The Journal of Biological Chemistry. 258: 12348-54. PMID 6313653 |
0.323 |
|
| 1983 |
Innerarity TL, Friedlander EJ, Rall SC, Weisgraber KH, Mahley RW. The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments. The Journal of Biological Chemistry. 258: 12341-7. PMID 6313652 |
0.351 |
|
| 1983 |
Rall SC, Weisgraber KH, Innerarity TL, Mahley RW. Identical structural and receptor binding defects in apolipoprotein E2 in hypo-, normo-, and hypercholesterolemic dysbetalipoproteinemia. The Journal of Clinical Investigation. 71: 1023-31. PMID 6300187 DOI: 10.1172/Jci110829 |
0.45 |
|
| 1982 |
Rall SC, Weisgraber KH, Innerarity TL, Mahley RW. Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects. Proceedings of the National Academy of Sciences of the United States of America. 79: 4696-700. PMID 6289314 |
0.316 |
|
| 1981 |
Mahley RW, Hui DY, Innerarity TL, Weisgraber KH. Two independent lipoprotein receptors on hepatic membranes of dog, swine, and man. Apo-B,E and apo-E receptors. The Journal of Clinical Investigation. 68: 1197-206. PMID 6271808 DOI: 10.1172/Jci110365 |
0.421 |
|
| 1980 |
Weisgraber KH, Troxler RF, Rall SC, Mahley RW. Comparison of the human, canine and swine E apoproteins. Biochemical and Biophysical Research Communications. 95: 374-80. PMID 7417263 DOI: 10.1016/0006-291X(80)90748-2 |
0.371 |
|
| 1980 |
Weisgraber KH, Mahley RW. Subfractionation of human high density lipoproteins by heparin-Sepharose affinity chromatography. Journal of Lipid Research. 21: 316-25. PMID 7381326 |
0.333 |
|
| 1980 |
Mahley RW, Weisgraber KH, Melchior GW, Innerarity TL, Holcombe KS. Inhibition of receptor-mediated clearance of lysine and arginine-modified lipoproteins from the plasma of rats and monkeys. Proceedings of the National Academy of Sciences of the United States of America. 77: 225-9. PMID 6767236 DOI: 10.1073/Pnas.77.1.225 |
0.361 |
|
| 1979 |
Mahley RW, Innerarity TL, Weisgraber KH, Oh SY. Altered Metabolism (In Vivo and In Vitro) of Plasma Lipoproteins after Selective Chemical Modification of Lysine Residues of the Apoproteins Journal of Clinical Investigation. 64: 743-750. PMID 224077 DOI: 10.1172/Jci109518 |
0.388 |
|
| 1979 |
Mahley RW, Weisgraber KH, Innerarity TL, Windmueller HG. Accelerated clearance of low-density and high-density lipoproteins and retarded clearance of E apoprotein-containing lipoproteins from the plasma of rats after modification of lysine residues. Proceedings of the National Academy of Sciences of the United States of America. 76: 1746-50. PMID 221905 DOI: 10.1073/Pnas.76.4.1746 |
0.391 |
|
| 1977 |
Weisgraber KH, Mahley RW, Assmann G. The rat arginine-rich apoprotein and its redistribution following injection of iodinated lipoproteins into normal and hypercholesterolemic rats. Atherosclerosis. 28: 121-40. PMID 199205 DOI: 10.1016/0021-9150(77)90150-2 |
0.369 |
|
| 1976 |
Mahley RW, Weisgraber KH, Innerarity T. Atherogenic hyperlipoproteinemia induced by cholesterol feeding the Patas monkey. Biochemistry. 15: 2979-85. PMID 182200 DOI: 10.1021/Bi00659A007 |
0.362 |
|
| 1975 |
Mahley RW, Weisgraber KH, Innerarity T, Brewer HB, Assmann G. Swine lipoproteins and atherosclerosis. Changes in the plasma lipoproteins and apoproteins induced by cholesterol feeding. Biochemistry. 14: 2817-23. PMID 167808 DOI: 10.1021/Bi00684A005 |
0.41 |
|
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