Year |
Citation |
Score |
2023 |
Campione SA, Kelliher CM, Orlando DA, Tran TQ, Haase SB. Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons. Journal of Visualized Experiments : Jove. PMID 37358275 DOI: 10.3791/65466 |
0.765 |
|
2019 |
Hu S, Marineau JJ, Rajagopal N, Hamman KB, Choi YJ, Schmidt DR, Ke N, Johannessen L, Bradley MJ, Orlando DA, Alnemy SR, Ren Y, Ciblat S, Winter DK, Kabro A, et al. Discovery and characterization of SY-1365, a selective, covalent inhibitor of CDK7. Cancer Research. PMID 31064851 DOI: 10.1158/0008-5472.Can-19-0119 |
0.427 |
|
2019 |
Hu S, Marineau J, Hamman K, Bradley M, Savinainen A, Alnemy S, Rajagopal N, Orlando D, Chuaqui C, Olson E. Abstract 4421: SY-5609, an orally available selective CDK7 inhibitor demonstrates broad anti-tumor activity in vivo Cancer Research. 79: 4421-4421. DOI: 10.1158/1538-7445.Sabcs18-4421 |
0.353 |
|
2019 |
Ke N, Johannessen L, Rajagopal N, Orlando D, Carulli J, Hodgson G. Abstract 4409: Prospective identification of RB pathway alterations predict response to SY-1365, a selective CDK7 inhibitor, in a panel of high-grade serous ovarian cancer (HGSOC) patient derived xenograft (PDX) models Cancer Research. 79: 4409-4409. DOI: 10.1158/1538-7445.Sabcs18-4409 |
0.312 |
|
2018 |
Guenther M, Lambert A, Chen M, Fiore C, Eaton M, Orlando D, Bierie B, Weinberg R, Fritz C, Olson E. Abstract P2-04-03: Epigenomic analysis of cancer stem cell (CSC)-enriched triple-negative breast cancer (TNBC) populations reveals gene regulatory circuitry and novel tumor cell vulnerabilities Cancer Research. 78. DOI: 10.1158/1538-7445.Sabcs17-P2-04-03 |
0.407 |
|
2018 |
Rajagopal N, Hodgson G, Hu S, McKeown M, Bush A, Fritz C, Orlando D, Olson E, Tomaso Ed. Abstract P1-09-08:BCL2L1(BCL-XL) expression and MYC super-enhancer positivity predict sensitivity to the covalent CDK7 inhibitor SY-1365 in triple negative breast cancer (TNBC) cell lines Cancer Research. 78. DOI: 10.1158/1538-7445.Sabcs17-P1-09-08 |
0.404 |
|
2018 |
Konstantinopoulos PA, Hodgson G, Rajagopal N, Johannessen L, Liu JF, Kirschmeier PT, Zhou S, Tran CA, Orlando D, Fritz C, Tomaso Ed, Matulonis UA. Abstract 1525: SY-1365, a selective CDK7 inhibitor, exhibits potent antitumor activity against ovarian cancer models in vitro and in vivo Cancer Research. 78: 1525-1525. DOI: 10.1158/1538-7445.Am2018-1525 |
0.349 |
|
2017 |
McKeown MR, Corces MR, Eaton ML, Fiore C, Lee E, Lopez JT, Chen MW, Smith D, Chan SM, Koenig JL, Austgen K, Guenther MG, Orlando DA, Lovén J, Fritz CC, et al. Super-Enhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML Including an RARα Dependency Targetable by SY-1425, a Potent and Selective RARα Agonist. Cancer Discovery. PMID 28729405 DOI: 10.1158/2159-8290.Cd-17-0399 |
0.364 |
|
2017 |
Hu S, Ke N, Ren Y, Miljovska S, Rajagopal N, McKeown M, Orlando D, Sprott K, Choi YJ, Olson E, Fritz CC. Abstract 1151: SY-1365, a potent and selective CDK7 inhibitor, exhibits promising anti-tumor activity in multiple preclinical models of aggressive solid tumors Cancer Research. 77: 1151-1151. DOI: 10.1158/1538-7445.Am2017-1151 |
0.414 |
|
2017 |
Bradley M, Marineau J, Choi Y, Hamman K, Malojcic G, Orlando D, Ren Y, Ke N, Hu S, Olson E, Fritz C, Roberts C. Abstract 1143: Targeting the transcriptional kinases CDK12 and CDK13 in breast and ovarian cancer Cancer Research. 77: 1143-1143. DOI: 10.1158/1538-7445.Am2017-1143 |
0.392 |
|
2016 |
Hu S, Ke N, Ren Y, Lopez J, Miljovska S, Orlando D, Schmidt D, Bradley M, Sprott K, Olson E, Fritz CC, Choi YJ. Abstract 4820: Selective CDK7 inhibitors suppress super enhancer-genes, induce massive apoptosis in acute myeloid leukemia and demonstrate durablein vivoefficacy Cancer Research. 76: 4820-4820. DOI: 10.1158/1538-7445.Am2016-4820 |
0.431 |
|
2015 |
Orlando DA, McKeown MR, Chen MW, Collins C, Guenther MG, Fritz CC. Abstract A1-69: Predicting drug response by profiling the epigenome: Super-enhancers as biomarkers Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-A1-69 |
0.326 |
|
2015 |
Guenther MG, Orlando DA, Eaton ML, Collins CA, Chen MW, Solanki S, Loven J, Fritz CC, Olson ER. Abstract P1-06-04: Super-enhancer analysis defines breast cancer subtype and identifies tumor dependencies Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P1-06-04 |
0.364 |
|
2015 |
Collins C, Chen MW, Eaton M, Orlando D, McKeown M, Fritz C, Olson E, Guenther M. Abstract 3837: Super-enhancers define breast cancer subclasses and identify novel tumor cell vulnerabilities Cancer Research. 75: 3837-3837. DOI: 10.1158/1538-7445.Am2015-3837 |
0.353 |
|
2014 |
Orlando DA, Chen MW, Brown VE, Solanki S, Choi YJ, Olson ER, Fritz CC, Bradner JE, Guenther MG. Quantitative ChIP-Seq normalization reveals global modulation of the epigenome. Cell Reports. 9: 1163-70. PMID 25437568 DOI: 10.1016/J.Celrep.2014.10.018 |
0.36 |
|
2013 |
Dowen JM, Bilodeau S, Orlando DA, Hübner MR, Abraham BJ, Spector DL, Young RA. Multiple structural maintenance of chromosome complexes at transcriptional regulatory elements. Stem Cell Reports. 1: 371-8. PMID 24286025 DOI: 10.1016/J.Stemcr.2013.09.002 |
0.403 |
|
2013 |
Li Y, Wang H, Muffat J, Cheng AW, Orlando DA, Lovén J, Kwok SM, Feldman DA, Bateup HS, Gao Q, Hockemeyer D, Mitalipova M, Lewis CA, Vander Heiden MG, Sur M, et al. Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons. Cell Stem Cell. 13: 446-58. PMID 24094325 DOI: 10.1016/J.Stem.2013.09.001 |
0.343 |
|
2013 |
Lovén J, Hoke HA, Lin CY, Lau A, Orlando DA, Vakoc CR, Bradner JE, Lee TI, Young RA. Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell. 153: 320-34. PMID 23582323 DOI: 10.1016/J.Cell.2013.03.036 |
0.393 |
|
2013 |
Whyte WA, Orlando DA, Hnisz D, Abraham BJ, Lin CY, Kagey MH, Rahl PB, Lee TI, Young RA. Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell. 153: 307-19. PMID 23582322 DOI: 10.1016/J.Cell.2013.03.035 |
0.482 |
|
2013 |
Guo X, Bernard A, Orlando DA, Haase SB, Hartemink AJ. Branching process deconvolution algorithm reveals a detailed cell-cycle transcription program. Proceedings of the National Academy of Sciences of the United States of America. 110: E968-77. PMID 23388635 DOI: 10.1073/Pnas.1120991110 |
0.738 |
|
2013 |
Sigova AA, Mullen AC, Molinie B, Gupta S, Orlando DA, Guenther MG, Almada AE, Lin C, Sharp PA, Giallourakis CC, Young RA. Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 2876-81. PMID 23382218 DOI: 10.1073/Pnas.1221904110 |
0.575 |
|
2013 |
Simmons Kovacs LA, Mayhew MB, Orlando DA, Jin Y, Li Q, Huang C, Reed SI, Mukherjee S, Haase SB. Errata to Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network [Molecular Cell, 45 (2012) 669-679] Molecular Cell. 49: 1177-1179. DOI: 10.1016/j.molcel.2013.03.007 |
0.788 |
|
2012 |
Lovén J, Orlando DA, Sigova AA, Lin CY, Rahl PB, Burge CB, Levens DL, Lee TI, Young RA. Revisiting global gene expression analysis. Cell. 151: 476-82. PMID 23101621 DOI: 10.1016/J.Cell.2012.10.012 |
0.4 |
|
2012 |
Orlando DA, Guenther MG, Frampton GM, Young RA. CpG island structure and trithorax/polycomb chromatin domains in human cells. Genomics. 100: 320-6. PMID 22819920 DOI: 10.1016/J.Ygeno.2012.07.006 |
0.352 |
|
2012 |
Simmons Kovacs LA, Mayhew MB, Orlando DA, Jin Y, Li Q, Huang C, Reed SI, Mukherjee S, Haase SB. Cyclin-dependent kinases are regulators and effectors of oscillations driven by a transcription factor network. Molecular Cell. 45: 669-79. PMID 22306294 DOI: 10.1016/J.Molcel.2011.12.033 |
0.692 |
|
2012 |
Whyte WA, Bilodeau S, Orlando DA, Hoke HA, Frampton GM, Foster CT, Cowley SM, Young RA. Enhancer decommissioning by LSD1 during embryonic stem cell differentiation. Nature. 482: 221-5. PMID 22297846 DOI: 10.1038/Nature10805 |
0.394 |
|
2011 |
Mullen AC, Orlando DA, Newman JJ, Lovén J, Kumar RM, Bilodeau S, Reddy J, Guenther MG, DeKoter RP, Young RA. Master transcription factors determine cell-type-specific responses to TGF-β signaling. Cell. 147: 565-76. PMID 22036565 DOI: 10.1016/J.Cell.2011.08.050 |
0.412 |
|
2011 |
Ceol CJ, Houvras Y, Jane-Valbuena J, Bilodeau S, Orlando DA, Battisti V, Fritsch L, Lin WM, Hollmann TJ, Ferré F, Bourque C, Burke CJ, Turner L, Uong A, Johnson LA, et al. The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. Nature. 471: 513-7. PMID 21430779 DOI: 10.1038/Nature09806 |
0.348 |
|
2011 |
Kagey MH, Newman JJ, Bilodeau S, Zhan Y, Orlando DA, Van Berkum NL, Ebmeier CC, Goossens J, Rahl PB, Levine SS, Taatjes DJ, Dekker J, Young RA. Mediator and cohesin connect gene expression and chromatin architecture (Nature (2010) 467 (430-435)) Nature. 472: 247. DOI: 10.1038/Nature09930 |
0.394 |
|
2010 |
Kagey MH, Newman JJ, Bilodeau S, Zhan Y, Orlando DA, van Berkum NL, Ebmeier CC, Goossens J, Rahl PB, Levine SS, Taatjes DJ, Dekker J, Young RA. Mediator and cohesin connect gene expression and chromatin architecture. Nature. 467: 430-5. PMID 20720539 DOI: 10.1038/nature09380 |
0.379 |
|
2010 |
Orlando DA, Brady SM, Fink TM, Benfey PN, Ahnert SE. Detecting separate time scales in genetic expression data. Bmc Genomics. 11: 381. PMID 20565716 DOI: 10.1186/1471-2164-11-381 |
0.677 |
|
2009 |
Orlando DA, Iversen ES, Hartemink AJ, Haase SB. A branching process model for flow cytometry and budding index measurements in cell synchrony experiments. The Annals of Applied Statistics. 3: 1521-1541. PMID 21853014 DOI: 10.1214/09-Aoas264 |
0.668 |
|
2009 |
Cartwright DA, Brady SM, Orlando DA, Sturmfels B, Benfey PN. Reconstructing spatiotemporal gene expression data from partial observations. Bioinformatics (Oxford, England). 25: 2581-7. PMID 19608707 DOI: 10.1093/Bioinformatics/Btp437 |
0.713 |
|
2009 |
Orlando DA, Brady SM, Koch JD, Dinneny JR, Benfey PN. Manipulating large-scale Arabidopsis microarray expression data: identifying dominant expression patterns and biological process enrichment. Methods in Molecular Biology (Clifton, N.J.). 553: 57-77. PMID 19588101 DOI: 10.1007/978-1-60327-563-7_4 |
0.779 |
|
2009 |
Crutchley J, King KM, Keaton MA, Szkotnicki L, Orlando DA, Zyla TR, Bardes ES, Lew DJ. Molecular dissection of the checkpoint kinase Hsl1p. Molecular Biology of the Cell. 20: 1926-36. PMID 19211841 DOI: 10.1091/Mbc.E08-08-0848 |
0.392 |
|
2008 |
Simmons Kovacs LA, Orlando DA, Haase SB. Transcription networks and cyclin/CDKs: the yin and yang of cell cycle oscillators. Cell Cycle (Georgetown, Tex.). 7: 2626-9. PMID 18758238 DOI: 10.4161/Cc.7.17.6515 |
0.757 |
|
2008 |
Chaudhuri B, Hörmann F, Lalonde S, Brady SM, Orlando DA, Benfey P, Frommer WB. Protonophore- and pH-insensitive glucose and sucrose accumulation detected by FRET nanosensors in Arabidopsis root tips. The Plant Journal : For Cell and Molecular Biology. 56: 948-62. PMID 18702670 DOI: 10.1111/J.1365-313X.2008.03652.X |
0.639 |
|
2008 |
Orlando DA, Lin CY, Bernard A, Wang JY, Socolar JE, Iversen ES, Hartemink AJ, Haase SB. Global control of cell-cycle transcription by coupled CDK and network oscillators. Nature. 453: 944-7. PMID 18463633 DOI: 10.1038/Nature06955 |
0.79 |
|
2007 |
Brady SM, Orlando DA, Lee JY, Wang JY, Koch J, Dinneny JR, Mace D, Ohler U, Benfey PN. A high-resolution root spatiotemporal map reveals dominant expression patterns. Science (New York, N.Y.). 318: 801-6. PMID 17975066 DOI: 10.1126/Science.1146265 |
0.778 |
|
2007 |
Orlando DA, Lin CY, Bernard A, Iversen ES, Hartemink AJ, Haase SB. A probabilistic model for cell cycle distributions in synchrony experiments. Cell Cycle (Georgetown, Tex.). 6: 478-88. PMID 17329975 DOI: 10.4161/Cc.6.4.3859 |
0.689 |
|
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