Hiten Madhani - Publications

Biochemistry and Molecular Biology University of California, San Francisco, San Francisco, CA 
Molecular Biology

82 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Brimacombe CA, Burke JE, Parsa JY, Catania S, O'Meara TR, Witchley JN, Burrack LS, Madhani HD, Noble SM. A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans. Plos Biology. 17: e3000331. PMID 31226107 DOI: 10.1371/journal.pbio.3000331  0.48
2019 Burke JE, Longhurst AD, Natarajan P, Rao B, Liu J, Sales-Lee J, Mortensen Y, Moresco JJ, Diedrich JK, Yates JR, Madhani HD. A Non-Dicer RNase III and Four Other Novel Factors Required for RNAi-Mediated Transposon Suppression in the Human Pathogenic Yeast . G3 (Bethesda, Md.). PMID 31092606 DOI: 10.1534/g3.119.400330  0.4
2018 Harrigan P, Madhani HD, El-Samad H. Real-Time Genetic Compensation Defines the Dynamic Demands of Feedback Control. Cell. 175: 877-886.e10. PMID 30340045 DOI: 10.1016/j.cell.2018.09.044  0.6
2018 Burke JE, Longhurst AD, Merkurjev D, Sales-Lee J, Rao B, Moresco JJ, Yates JR, Li JJ, Madhani HD. Spliceosome Profiling Visualizes Operations of a Dynamic RNP at Nucleotide Resolution. Cell. 173: 1014-1030.e17. PMID 29727661 DOI: 10.1016/j.cell.2018.03.020  0.4
2018 Garcia-Santamarina S, Festa RA, Smith AD, Yu CH, Probst C, Ding C, Homer CM, Yin J, Noonan JP, Madhani H, Perfect JR, Thiele DJ. Genome-wide analysis of the regulation of Cu metabolism in Cryptococcus neoformans. Molecular Microbiology. PMID 29608794 DOI: 10.1111/mmi.13960  0.32
2018 Roth R, Madhani HD, Garcia JF. Total RNA Isolation and Quantification of Specific RNAs in Fission Yeast. Methods in Molecular Biology (Clifton, N.J.). 1721: 63-72. PMID 29423847 DOI: 10.1007/978-1-4939-7546-4_6  0.6
2016 Clarke SC, Dumesic PA, Homer CM, O'Donoghue AJ, La Greca F, Pallova L, Majer P, Madhani HD, Craik CS. Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence. Plos Pathogens. 12: e1006051. PMID 27977806 DOI: 10.1371/journal.ppat.1006051  1
2016 Inada M, Nichols RJ, Parsa JY, Homer CM, Benn RA, Hoxie RS, Madhani HD, Shuman S, Schwer B, Pleiss JA. Phospho-site mutants of the RNA Polymerase II C-terminal domain alter subtelomeric gene expression and chromatin modification state in fission yeast. Nucleic Acids Research. PMID 27402158 DOI: 10.1093/nar/gkw603  0.32
2016 Homer CM, Summers DK, Goranov AI, Clarke SC, Wiesner DL, Diedrich JK, Moresco JJ, Toffaletti D, Upadhya R, Caradonna I, Petnic S, Pessino V, Cuomo CA, Lodge JK, Perfect J, ... ... Madhani HD, et al. Intracellular Action of a Secreted Peptide Required for Fungal Virulence. Cell Host & Microbe. PMID 27212659 DOI: 10.1016/j.chom.2016.05.001  1
2015 Dumesic PA, Rosenblad MA, Samuelsson T, Nguyen T, Moresco JJ, Yates JR, Madhani HD. Noncanoncial signal recognition particle RNAs in a major eukaryotic phylum revealed by purification of SRP from the human pathogen Cryptococcus neoformans. Nucleic Acids Research. PMID 26275773 DOI: 10.1093/nar/gkv819  1
2015 Desjardins CA, Sanscrainte ND, Goldberg JM, Heiman D, Young S, Zeng Q, Madhani HD, Becnel JJ, Cuomo CA. Contrasting host-pathogen interactions and genome evolution in two generalist and specialist microsporidian pathogens of mosquitoes. Nature Communications. 6: 7121. PMID 25968466 DOI: 10.1038/ncomms8121  1
2015 Garcia JF, Al-Sady B, Madhani HD. Intrinsic Toxicity of Unchecked Heterochromatin Spread Is Suppressed by Redundant Chromatin Boundary Functions in Schizosacchromyces pombe. G3 (Bethesda, Md.). 5: 1453-61. PMID 25957277 DOI: 10.1534/g3.115.018663  1
2015 Dumesic PA, Homer CM, Moresco JJ, Pack LR, Shanle EK, Coyle SM, Strahl BD, Fujimori DG, Yates JR, Madhani HD. Product binding enforces the genomic specificity of a yeast polycomb repressive complex. Cell. 160: 204-18. PMID 25533783 DOI: 10.1016/j.cell.2014.11.039  1
2015 Goranov AI, Madhani HD. Functional profiling of human fungal pathogen genomes. Cold Spring Harbor Perspectives in Medicine. 5: a019596. PMID 25377143 DOI: 10.1101/cshperspect.a019596  1
2014 Brown JC, Nelson J, VanderSluis B, Deshpande R, Butts A, Kagan S, Polacheck I, Krysan DJ, Myers CL, Madhani HD. Unraveling the biology of a fungal meningitis pathogen using chemical genetics. Cell. 159: 1168-87. PMID 25416953 DOI: 10.1016/j.cell.2014.10.044  1
2014 Butts A, Koselny K, Chabrier-Roselló Y, Semighini CP, Brown JC, Wang X, Annadurai S, DiDone L, Tabroff J, Childers WE, Abou-Gharbia M, Wellington M, Cardenas ME, Madhani HD, Heitman J, et al. Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo. Mbio. 5: e00765-13. PMID 24520056 DOI: 10.1128/mBio.00765-13  1
2014 Dumesic PA, Madhani HD. Recognizing the enemy within: licensing RNA-guided genome defense. Trends in Biochemical Sciences. 39: 25-34. PMID 24280023 DOI: 10.1016/j.tibs.2013.10.003  1
2013 Dumesic PA, Madhani HD. The spliceosome as a transposon sensor. Rna Biology. 10: 1653-60. PMID 24418889 DOI: 10.4161/rna.26800  1
2013 Madhani HD. snRNA catalysts in the spliceosome's ancient core. Cell. 155: 1213-5. PMID 24315092 DOI: 10.1016/j.cell.2013.11.022  1
2013 Madhani HD. The frustrated gene: origins of eukaryotic gene expression. Cell. 155: 744-9. PMID 24209615 DOI: 10.1016/j.cell.2013.10.003  1
2013 Marina DB, Shankar S, Natarajan P, Finn KJ, Madhani HD. A conserved ncRNA-binding protein recruits silencing factors to heterochromatin through an RNAi-independent mechanism. Genes & Development. 27: 1851-6. PMID 24013500 DOI: 10.1101/gad.226019.113  1
2013 Al-Sady B, Madhani HD, Narlikar GJ. Division of labor between the chromodomains of HP1 and Suv39 methylase enables coordination of heterochromatin spread. Molecular Cell. 51: 80-91. PMID 23849629 DOI: 10.1016/j.molcel.2013.06.013  1
2013 Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Marina DB, Garcia JF, Madhani HD, Cooke R, Schuck P, Cheng Y, Narlikar GJ. A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature. 496: 377-81. PMID 23485968 DOI: 10.1038/nature12032  1
2013 Dumesic PA, Natarajan P, Chen C, Drinnenberg IA, Schiller BJ, Thompson J, Moresco JJ, Yates JR, Bartel DP, Madhani HD. Stalled spliceosomes are a signal for RNAi-mediated genome defense. Cell. 152: 957-68. PMID 23415457 DOI: 10.1016/j.cell.2013.01.046  1
2012 Brown JC, Madhani HD. Approaching the functional annotation of fungal virulence factors using cross-species genetic interaction profiling. Plos Genetics. 8: e1003168. PMID 23300468 DOI: 10.1371/journal.pgen.1003168  1
2012 Xu M, Soloveychik M, Ranger M, Schertzberg M, Shah Z, Raisner R, Venkatasubrahmanyan S, Tsui K, Gebbia M, Hughes T, van Bakel H, Nislow C, Madhani HD, Meneghini MD. Timing of transcriptional quiescence during gametogenesis is controlled by global histone H3K4 demethylation. Developmental Cell. 23: 1059-71. PMID 23123093 DOI: 10.1016/j.devcel.2012.10.005  1
2012 Rougemaille M, Braun S, Coyle S, Dumesic PA, Garcia JF, Isaac RS, Libri D, Narlikar GJ, Madhani HD. Ers1 links HP1 to RNAi. Proceedings of the National Academy of Sciences of the United States of America. 109: 11258-63. PMID 22733737 DOI: 10.1073/pnas.1204947109  1
2012 Braun S, Madhani HD. Shaping the landscape: mechanistic consequences of ubiquitin modification of chromatin. Embo Reports. 13: 619-30. PMID 22688965 DOI: 10.1038/embor.2012.78  1
2011 Madhani HD. Quorum sensing in fungi: Q&A. Plos Pathogens. 7: e1002301. PMID 22046125 DOI: 10.1371/journal.ppat.1002301  1
2011 Kiely CM, Marguerat S, Garcia JF, Madhani HD, Bähler J, Winston F. Spt6 is required for heterochromatic silencing in the fission yeast Schizosaccharomyces pombe. Molecular and Cellular Biology. 31: 4193-204. PMID 21844224 DOI: 10.1128/MCB.05568-11  1
2011 El-Samad H, Madhani HD. Can a systems perspective help us appreciate the biological meaning of small effects? Developmental Cell. 21: 11-3. PMID 21763599 DOI: 10.1016/j.devcel.2011.06.005  1
2011 Charles GM, Chen C, Shih SC, Collins SR, Beltrao P, Zhang X, Sharma T, Tan S, Burlingame AL, Krogan NJ, Madhani HD, Narlikar GJ. Site-specific acetylation mark on an essential chromatin-remodeling complex promotes resistance to replication stress. Proceedings of the National Academy of Sciences of the United States of America. 108: 10620-5. PMID 21673141 DOI: 10.1073/pnas.1019735108  1
2011 Chun CD, Brown JC, Madhani HD. A major role for capsule-independent phagocytosis-inhibitory mechanisms in mammalian infection by Cryptococcus neoformans. Cell Host & Microbe. 9: 243-51. PMID 21402362 DOI: 10.1016/j.chom.2011.02.003  1
2011 Braun S, Garcia JF, Rowley M, Rougemaille M, Shankar S, Madhani HD. The Cul4-Ddb1(Cdt)² ubiquitin ligase inhibits invasion of a boundary-associated antisilencing factor into heterochromatin. Cell. 144: 41-54. PMID 21215368 DOI: 10.1016/j.cell.2010.11.051  1
2010 Chun CD, Madhani HD. Applying genetics and molecular biology to the study of the human pathogen Cryptococcus neoformans. Methods in Enzymology. 470: 797-831. PMID 20946836 DOI: 10.1016/S0076-6879(10)70033-1  1
2010 McCullagh E, Seshan A, El-Samad H, Madhani HD. Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathway. Nature Cell Biology. 12: 954-62. PMID 20852627 DOI: 10.1038/ncb2097  1
2010 Chun CD, Madhani HD. Ctr2 links copper homeostasis to polysaccharide capsule formation and phagocytosis inhibition in the human fungal pathogen Cryptococcus neoformans. Plos One. 5. PMID 20824073 DOI: 10.1371/journal.pone.0012503  1
2010 Garcia JF, Dumesic PA, Hartley PD, El-Samad H, Madhani HD. Combinatorial, site-specific requirement for heterochromatic silencing factors in the elimination of nucleosome-free regions. Genes & Development. 24: 1758-71. PMID 20675407 DOI: 10.1101/gad.1946410  1
2010 Bao MZ, Shock TR, Madhani HD. Multisite phosphorylation of the Saccharomyces cerevisiae filamentous growth regulator Tec1 is required for its recognition by the E3 ubiquitin ligase adaptor Cdc4 and its subsequent destruction in vivo. Eukaryotic Cell. 9: 31-6. PMID 19897738 DOI: 10.1128/EC.00250-09  1
2009 Hwang WW, Madhani HD. Nonredundant requirement for multiple histone modifications for the early anaphase release of the mitotic exit regulator Cdc14 from nucleolar chromatin. Plos Genetics. 5: e1000588. PMID 19662160 DOI: 10.1371/journal.pgen.1000588  1
2009 Hartley PD, Madhani HD. Mechanisms that specify promoter nucleosome location and identity. Cell. 137: 445-58. PMID 19410542 DOI: 10.1016/j.cell.2009.02.043  1
2009 Shock TR, Thompson J, Yates JR, Madhani HD. Hog1 mitogen-activated protein kinase (MAPK) interrupts signal transduction between the Kss1 MAPK and the Tec1 transcription factor to maintain pathway specificity. Eukaryotic Cell. 8: 606-16. PMID 19218425 DOI: 10.1128/EC.00005-09  1
2009 Madhani HD, Haldar K, McFadden G. "Pearls": A new type of open-access educational resource Plos Pathogens. 5. DOI: 10.1371/journal.ppat.1000499  1
2008 Liu OW, Chun CD, Chow ED, Chen C, Madhani HD, Noble SM. Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans. Cell. 135: 174-88. PMID 18854164 DOI: 10.1016/j.cell.2008.07.046  1
2008 Madhani HD, Francis NJ, Kingston RE, Kornberg RD, Moazed D, Narlikar GJ, Panning B, Struhl K. Epigenomics: a roadmap, but to where? Science (New York, N.Y.). 322: 43-4. PMID 18832628 DOI: 10.1126/science.322.5898.43b  1
2008 Raisner RM, Madhani HD. Genomewide screen for negative regulators of sirtuin activity in Saccharomyces cerevisiae reveals 40 loci and links to metabolism. Genetics. 179: 1933-44. PMID 18689887 DOI: 10.1534/genetics.108.088443  1
2008 Rougemaille M, Shankar S, Braun S, Rowley M, Madhani HD. Ers1, a rapidly diverging protein essential for RNA interference-dependent heterochromatic silencing in Schizosaccharomyces pombe. The Journal of Biological Chemistry. 283: 25770-3. PMID 18658154 DOI: 10.1074/jbc.C800140200  1
2008 Breslow DK, Cameron DM, Collins SR, Schuldiner M, Stewart-Ornstein J, Newman HW, Braun S, Madhani HD, Krogan NJ, Weissman JS. A comprehensive strategy enabling high-resolution functional analysis of the yeast genome. Nature Methods. 5: 711-8. PMID 18622397 DOI: 10.1038/nmeth.1234  1
2008 Raisner RM, Hartley PD, Meneghini MD, Bao MZ, Liu CL, Schreiber SL, Rando OJ, Madhani HD. Histone Variant H2A.Z Marks the 5′ Ends of Both Active and Inactive Genes in Euchromatin (DOI:10.1016/j.cell.2005.10.002) Cell. 134: 188. DOI: 10.1016/j.cell.2008.06.046  1
2007 Venkatasubrahmanyam S, Hwang WW, Meneghini MD, Tong AH, Madhani HD. Genome-wide, as opposed to local, antisilencing is mediated redundantly by the euchromatic factors Set1 and H2A.Z. Proceedings of the National Academy of Sciences of the United States of America. 104: 16609-14. PMID 17925448 DOI: 10.1073/pnas.0700914104  1
2007 Chow ED, Liu OW, O'Brien S, Madhani HD. Exploration of whole-genome responses of the human AIDS-associated yeast pathogen Cryptococcus neoformans var grubii: nitric oxide stress and body temperature. Current Genetics. 52: 137-48. PMID 17661046 DOI: 10.1007/s00294-007-0147-9  1
2007 Cantin GT, Shock TR, Park SK, Madhani HD, Yates JR. Optimizing TiO2-based phosphopeptide enrichment for automated multidimensional liquid chromatography coupled to tandem mass spectrometry. Analytical Chemistry. 79: 4666-73. PMID 17523591 DOI: 10.1021/ac0618730  1
2007 Liu OW, Kelly MJ, Chow ED, Madhani HD. Parallel beta-helix proteins required for accurate capsule polysaccharide synthesis and virulence in the yeast Cryptococcus neoformans. Eukaryotic Cell. 6: 630-40. PMID 17337638 DOI: 10.1128/EC.00398-06  1
2007 Chun CD, Liu OW, Madhani HD. A link between virulence and homeostatic responses to hypoxia during infection by the human fungal pathogen Cryptococcus neoformans. Plos Pathogens. 3: e22. PMID 17319742 DOI: 10.1371/journal.ppat.0030022  1
2007 Tompa R, Madhani HD. Histone H3 lysine 36 methylation antagonizes silencing in Saccharomyces cerevisiae independently of the Rpd3S histone deacetylase complex. Genetics. 175: 585-93. PMID 17179083 DOI: 10.1534/genetics.106.067751  1
2006 Madhani HD. Functional analysis of protein kinase networks in living cells: beyond "knock-outs" and "knock-downs". Methods (San Diego, Calif.). 40: 251-4. PMID 16884918 DOI: 10.1016/j.ymeth.2006.06.006  1
2006 Raisner RM, Madhani HD. Patterning chromatin: form and function for H2A.Z variant nucleosomes. Current Opinion in Genetics & Development. 16: 119-24. PMID 16503125 DOI: 10.1016/j.gde.2006.02.005  1
2006 Schwartz MA, Madhani HD. Control of MAPK signaling specificity by a conserved residue in the MEK-binding domain of the yeast scaffold protein Ste5. Current Genetics. 49: 351-63. PMID 16463042 DOI: 10.1007/s00294-006-0061-6  1
2005 Raisner RM, Hartley PD, Meneghini MD, Bao MZ, Liu CL, Schreiber SL, Rando OJ, Madhani HD. Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin. Cell. 123: 233-48. PMID 16239142 DOI: 10.1016/j.cell.2005.10.002  1
2004 Bao MZ, Schwartz MA, Cantin GT, Yates JR, Madhani HD. Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast. Cell. 119: 991-1000. PMID 15620357 DOI: 10.1016/j.cell.2004.11.052  1
2004 Schwartz MA, Madhani HD. Principles of MAP kinase signaling specificity in Saccharomyces cerevisiae. Annual Review of Genetics. 38: 725-48. PMID 15568991 DOI: 10.1146/annurev.genet.39.073003.112634  1
2004 Kobor MS, Venkatasubrahmanyam S, Meneghini MD, Gin JW, Jennings JL, Link AJ, Madhani HD, Rine J. A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin. Plos Biology. 2: E131. PMID 15045029 DOI: 10.1371/journal.pbio.0020131  1
2003 Meneghini MD, Wu M, Madhani HD. Conserved histone variant H2A.Z protects euchromatin from the ectopic spread of silent heterochromatin. Cell. 112: 725-36. PMID 12628191 DOI: 10.1016/S0092-8674(03)00123-5  1
2003 Hwang WW, Venkatasubrahmanyam S, Ianculescu AG, Tong A, Boone C, Madhani HD. A conserved RING finger protein required for histone H2B monoubiquitination and cell size control. Molecular Cell. 11: 261-6. PMID 12535538 DOI: 10.1016/S1097-2765(02)00826-2  1
2002 Brugnera E, Haney L, Grimsley C, Lu M, Walk SF, Tosello-Trampont AC, Macara IG, Madhani H, Fink GR, Ravichandran KS. Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Nature Cell Biology. 4: 574-82. PMID 12134158 DOI: 10.1038/ncb824  1
2001 Madhani HD. Accounting for specificity in receptor tyrosine kinase signaling Cell. 106: 9-11. PMID 11461696 DOI: 10.1016/S0092-8674(01)00422-6  1
2000 Madhani HD. Interplay of intrinsic and extrinsic signals in yeast differentiation Proceedings of the National Academy of Sciences of the United States of America. 97: 13461-13463. PMID 11095703 DOI: 10.1073/pnas.011511198  1
1999 Madhani HD, Galitski T, Lander ES, Fink GR. Effectors of a developmental mitogen-activated protein kinase cascade revealed by expression signatures of signaling mutants. Proceedings of the National Academy of Sciences of the United States of America. 96: 12530-5. PMID 10535956 DOI: 10.1073/pnas.96.22.12530  1
1999 Rupp S, Summers E, Lo HJ, Madhani H, Fink G. MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene Embo Journal. 18: 1257-1269. PMID 10064592  1
1998 Madhani HD, Fink GR. The control of filamentous differentiation and virulence in fungi Trends in Cell Biology. 8: 348-353. PMID 9728395 DOI: 10.1016/S0962-8924(98)01298-7  1
1998 Madhani HD, Fink GR. The riddle of MAP kinase signaling specificity Trends in Genetics. 14: 151-155. PMID 9594663 DOI: 10.1016/S0168-9525(98)01425-5  1
1997 Madhani HD, Styles CA, Fink GR. MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation Cell. 91: 673-684. PMID 9393860  1
1997 Madhani HD, Fink GR. Combinatorial control required for the specificity of yeast MAPK signaling Science. 275: 1314-1317. PMID 9036858 DOI: 10.1126/science.275.5304.1314  1
1994 Madhani HD, Guthrie C. Genetic interactions between the yeast RNA helicase homolog Prp16 and spliceosomal snRNAs identify candidate ligands for the Prp16 RNA-dependent ATPase. Genetics. 137: 677-87. PMID 8088513  1
1994 Madhani HD, Guthrie C. Randomization-selection analysis of snRNAs in vivo: evidence for a tertiary interaction in the spliceosome. Genes & Development. 8: 1071-86. PMID 7926788  1
1994 Madhani HD, Guthrie C. Dynamic RNA-RNA interactions in the spliceosome. Annual Review of Genetics. 28: 1-26. PMID 7534458 DOI: 10.1146/annurev.ge.28.120194.000245  1
1992 Madhani HD, Guthrie C. A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome Cell. 71: 803-817. PMID 1423631 DOI: 10.1016/0092-8674(92)90556-R  1
1990 Madhani HD, Bordonné R, Guthrie C. Multiple roles for U6 snRNA in the splicing pathway Genes and Development. 4: 2264-2277. PMID 2149118  1
1990 Guthrie C, Madhani HD. Greetings from the RNA world New Biologist. 2: 684-687. PMID 1704252  1
1988 Jacks T, Madhani HD, Masiarz FR, Varmus HE. Signals for ribosomal frameshifting in the rous sarcoma virus gag-pol region Cell. 55: 447-458. PMID 2846182 DOI: 10.1016/0092-8674(88)90031-1  1
1986 Madhani HD, Bohr VA, Hanawalt PC. Differential DNA repair in transcriptionally active and inactive proto-oncogenes: c-abl and c-mos. Cell. 45: 417-23. PMID 3698104 DOI: 10.1016/0092-8674(86)90327-2  1
1986 Madhani HD, Leadon SA, Smith CA, Hanawalt PC. alpha DNA in African green monkey cells is organized into extremely long tandem arrays. The Journal of Biological Chemistry. 261: 2314-8. PMID 3003109  1
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