Beverly H. Koller - Publications

Genetics & Molecular Biology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Genetics, Molecular Biology

141 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Perryman A, Speen AM, Kim HH, Hoffman JR, Clapp PW, Rivera Martin W, Snouwaert JN, Koller BH, Porter NA, Jaspers I. Oxysterols Modify NLRP2 in Epithelial Cells, Identifying a Mediator of Ozone-induced Inflammation. American Journal of Respiratory Cell and Molecular Biology. PMID 34126877 DOI: 10.1165/rcmb.2021-0032OC  0.32
2021 Conde E, Bertrand R, Balbino B, Bonnefoy J, Stackowicz J, Caillot N, Colaone F, Hamdi S, Houmadi R, Loste A, Kamphuis JBJ, Huetz F, Guilleminault L, Gaudenzio N, Mougel A, ... ... Koller BH, et al. Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice. Nature Communications. 12: 2574. PMID 33976140 DOI: 10.1038/s41467-021-22834-5  0.32
2020 Koller BH, Snouwaert JN, Douillet C, Jania LA, El-Masri H, Thomas DJ, Stýblo M. Arsenic Metabolism in Mice Carrying a Locus Humanized by Syntenic Replacement. Environmental Health Perspectives. 128: 87003. PMID 32779937 DOI: 10.1289/Ehp6943  0.32
2019 Behrens KA, Jania LA, Snouwaert JN, Nguyen M, Moy SS, Tikunov AP, Macdonald JM, Koller BH. Beyond detoxification: Pleiotropic functions of multiple glutathione S-transferase isoforms protect mice against a toxic electrophile. Plos One. 14: e0225449. PMID 31747445 DOI: 10.1371/Journal.Pone.0225449  0.32
2019 Snouwaert JN, Jania L, Nguyen M, Dontu P, Besse J, Akla B, Ferré PJ, Koller BH. Abstract 503: Prostaglandin E2 produced by tumor cells or by the host tumor microenvironment is not completely abolished by aspirin or celecoxib and limits the ability of the host immune system to control tumor growth Cancer Research. 79: 503-503. DOI: 10.1158/1538-7445.Am2019-503  0.32
2018 Snouwaert JN, Church RJ, Jania L, Nguyen M, Wheeler ML, Saintsing A, Mieczkowski P, Manuel de Villena FP, Armao D, Moy SS, Lorenzo DN, Koller BH. A Mutation in the Borcs7 Subunit of the Lysosome Regulatory BORC Complex Results in Motor Deficits and Dystrophic Axonopathy in Mice. Cell Reports. 24: 1254-1265. PMID 30067980 DOI: 10.1016/J.Celrep.2018.06.118  0.32
2016 Snouwaert JN, Nguyen M, Repenning PW, Dye R, Livingston EW, Kovarova M, Moy SS, Brigman BE, Bateman TA, Ting JP, Koller BH. An NLRP3 Mutation Causes Arthropathy and Osteoporosis in Humanized Mice. Cell Reports. 17: 3077-3088. PMID 27974218 DOI: 10.1016/J.Celrep.2016.11.052  0.32
2015 Fay MJ, Nguyen MT, Snouwaert JN, Dye R, Grant DJ, Bodnar WM, Koller BH. Xenobiotic Metabolism in Mice Lacking the UDP-Glucuronosyltransferase 2 Family. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 1838-46. PMID 26354949 DOI: 10.1124/Dmd.115.065482  0.32
2015 Yang Y, Gomez JA, Herrera M, Perez-Marco R, Repenning P, Zhang Z, Payne A, Pratt RE, Koller B, Beierwaltes WH, Coffman T, Mirotsou M, Dzau VJ. Salt restriction leads to activation of adult renal mesenchymal stromal cell-like cells via prostaglandin E2 and E-prostanoid receptor 4. Hypertension. 65: 1047-54. PMID 25776075 DOI: 10.1161/Hypertensionaha.114.04611  0.76
2015 Kaushal V, Dye R, Pakavathkumar P, Foveau B, Flores J, Hyman B, Ghetti B, Koller BH, LeBlanc AC. Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation. Cell Death and Differentiation. PMID 25744023 DOI: 10.1038/Cdd.2015.16  0.76
2014 Kovarova M, Koller BH. PGE₂ promotes apoptosis induced by cytokine deprivation through EP3 receptor and induces Bim in mouse mast cells. Plos One. 9: e102948. PMID 25054560 DOI: 10.1371/Journal.Pone.0102948  0.76
2014 Xiang Z, Snouwaert JN, Kovarova M, Nguyen M, Repenning PW, Latour AM, Cyphert JM, Koller BH. Mice lacking three Loci encoding 14 glutathione transferase genes: a novel tool for assigning function to the GSTP, GSTM, and GSTT families. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 1074-83. PMID 24658454 DOI: 10.1124/Dmd.113.056481  0.76
2014 Gorfu G, Cirelli KM, Melo MB, Mayer-Barber K, Crown D, Koller BH, Masters S, Sher A, Leppla SH, Moayeri M, Saeij JP, Grigg ME. Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii. Mbio. 5. PMID 24549849 DOI: 10.1128/Mbio.01117-13  0.76
2013 Abdul-Sater AA, Tattoli I, Jin L, Grajkowski A, Levi A, Koller BH, Allen IC, Beaucage SL, Fitzgerald KA, Ting JP, Cambier JC, Girardin SE, Schindler C. Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome. Embo Reports. 14: 900-6. PMID 24008845 DOI: 10.1038/Embor.2013.132  0.76
2013 Sparks MA, Makhanova NA, Griffiths RC, Snouwaert JN, Koller BH, Coffman TM. Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death. Hypertension. 61: 166-73. PMID 23150508 DOI: 10.1161/Hypertensionaha.112.193250  0.76
2012 Hesker PR, Nguyen M, Kovarova M, Ting JP, Koller BH. Genetic loss of murine pyrin, the Familial Mediterranean Fever protein, increases interleukin-1β levels. Plos One. 7: e51105. PMID 23226472 DOI: 10.1371/Journal.Pone.0051105  0.76
2012 Schneider M, Zimmermann AG, Roberts RA, Zhang L, Swanson KV, Wen H, Davis BK, Allen IC, Holl EK, Ye Z, Rahman AH, Conti BJ, Eitas TK, Koller BH, Ting JP. The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. Nature Immunology. 13: 823-31. PMID 22863753 DOI: 10.1038/Ni.2378  0.76
2012 Kovarova M, Hesker PR, Jania L, Nguyen M, Snouwaert JN, Xiang Z, Lommatzsch SE, Huang MT, Ting JP, Koller BH. NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice. Journal of Immunology (Baltimore, Md. : 1950). 189: 2006-16. PMID 22753929 DOI: 10.4049/Jimmunol.1201065  0.76
2012 Moy SS, Nikolova VD, Riddick NV, Baker LK, Koller BH. Preweaning sensorimotor deficits and adolescent hypersociability in Grin1 knockdown mice. Developmental Neuroscience. 34: 159-73. PMID 22571986 DOI: 10.1159/000337984  0.76
2012 Kovarova M, Koller B. Differentiation of mast cells from embryonic stem cells. Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. Unit 22F.10.1-16. PMID 22470136 DOI: 10.1002/0471142735.Im22F10S97  0.76
2012 Church RJ, Jania LA, Koller BH. Prostaglandin E(2) produced by the lung augments the effector phase of allergic inflammation. Journal of Immunology (Baltimore, Md. : 1950). 188: 4093-102. PMID 22412193 DOI: 10.4049/Jimmunol.1101873  0.76
2012 Gruzdev A, Nguyen M, Kovarova M, Koller BH. PGE2 through the EP4 receptor controls smooth muscle gene expression patterns in the ductus arteriosus critical for remodeling at birth. Prostaglandins & Other Lipid Mediators. 97: 109-19. PMID 22342504 DOI: 10.1016/J.Prostaglandins.2012.02.001  0.76
2012 Allen IC, Jania CM, Wilson JE, Tekeppe EM, Hua X, Brickey WJ, Kwan M, Koller BH, Tilley SL, Ting JP. Analysis of NLRP3 in the development of allergic airway disease in mice. Journal of Immunology (Baltimore, Md. : 1950). 188: 2884-93. PMID 22323538 DOI: 10.4049/Jimmunol.1102488  0.76
2012 Duncan GE, Koller BH, Moy SS. Effects of the selective kainate receptor antagonist ACET on altered sensorimotor gating in a genetic model of reduced NMDA receptor function. Brain Research. 1443: 98-105. PMID 22297176 DOI: 10.1016/J.Brainres.2012.01.009  0.76
2012 Ledford JG, Kovarova M, Jania LA, Nguyen M, Koller BH. ONZIN deficiency attenuates contact hypersensitivity responses in mice. Immunology and Cell Biology. 90: 733-42. PMID 22249203 DOI: 10.1038/Icb.2011.107  0.76
2012 Cyphert JM, Allen IC, Church RJ, Latour AM, Snouwaert JN, Coffman TM, Koller BH. Allergic inflammation induces a persistent mechanistic switch in thromboxane-mediated airway constriction in the mouse. American Journal of Physiology. Lung Cellular and Molecular Physiology. 302: L140-51. PMID 21984570 DOI: 10.1152/Ajplung.00152.2011  0.76
2011 Facemire CS, Nguyen M, Jania L, Beierwaltes WH, Kim HS, Koller BH, Coffman TM. A major role for the EP4 receptor in regulation of renin. American Journal of Physiology. Renal Physiology. 301: F1035-41. PMID 21835766 DOI: 10.1152/Ajprenal.00054.2011  0.76
2011 Gurley SB, Riquier-Brison AD, Schnermann J, Sparks MA, Allen AM, Haase VH, Snouwaert JN, Le TH, McDonough AA, Koller BH, Coffman TM. AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metabolism. 13: 469-75. PMID 21459331 DOI: 10.1016/J.Cmet.2011.03.001  0.76
2011 Kim WK, Park JS, Sul OJ, Seo JH, Choi BK, Park HY, Latour AM, Koller BH, Kwon BS, Jeong CS. Role of TNFR-related 2 mediated immune responses in dextran sulfate sodium-induced inflammatory bowel disease. Molecules and Cells. 31: 99-104. PMID 21347711 DOI: 10.1007/S10059-011-0013-Y  0.76
2011 Sparks MA, Parsons KK, Stegbauer J, Gurley SB, Vivekanandan-Giri A, Fortner CN, Snouwaert J, Raasch EW, Griffiths RC, Haystead TA, Le TH, Pennathur S, Koller B, Coffman TM. Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension. Hypertension. 57: 577-85. PMID 21242463 DOI: 10.1161/Hypertensionaha.110.165274  0.76
2011 Cyphert JM, Kovarova M, Koller BH. Unique populations of lung mast cells are required for antigen-mediated bronchoconstriction. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. 41: 260-9. PMID 20718780 DOI: 10.1111/J.1365-2222.2010.03583.X  0.76
2010 Kim WK, Sul OJ, Kwak JS, Hur HY, Latour AM, Koller BH, Kwon BS, Jeong CS. Nuclear factor of activated T cells negatively regulates expression of the tumor necrosis factor receptor-related 2 gene in T cells. Experimental & Molecular Medicine. 42: 805-10. PMID 20948279 DOI: 10.3858/Emm.2010.42.12.083  0.76
2010 Arthur JC, Lich JD, Ye Z, Allen IC, Gris D, Wilson JE, Schneider M, Roney KE, O'Connor BP, Moore CB, Morrison A, Sutterwala FS, Bertin J, Koller BH, Liu Z, et al. Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity. Journal of Immunology (Baltimore, Md. : 1950). 185: 4515-9. PMID 20861349 DOI: 10.4049/Jimmunol.1002227  0.76
2010 Koller BH, Marrack P, Kappler JW, Smithies O. Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. 1990. Journal of Immunology (Baltimore, Md. : 1950). 184: 4592-5. PMID 20410496  0.76
2010 Kovarova M, Latour AM, Chason KD, Tilley SL, Koller BH. Human embryonic stem cells: a source of mast cells for the study of allergic and inflammatory diseases. Blood. 115: 3695-703. PMID 20200352 DOI: 10.1182/Blood-2009-08-237206  0.76
2010 Facemire CS, Griffiths R, Audoly LP, Koller BH, Coffman TM. The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background. Hypertension. 55: 531-8. PMID 20065147 DOI: 10.1161/Hypertensionaha.109.145631  0.76
2010 Duncan GE, Inada K, Koller BH, Moy SS. Increased sensitivity to kainic acid in a genetic model of reduced NMDA receptor function. Brain Research. 1307: 166-76. PMID 19840778 DOI: 10.1016/J.Brainres.2009.10.023  0.76
2010 Koller BH, Marrack P, Kappler JW, Smithies O. Normal development of mice deficient in β2M, MHC class I proteins, and CD8+ T cells Journal of Immunology. 184: 1227-1230. DOI: 10.1126/science.2112266  0.76
2009 Cyphert JM, Kovarova M, Allen IC, Hartney JM, Murphy DL, Wess J, Koller BH. Cooperation between mast cells and neurons is essential for antigen-mediated bronchoconstriction. Journal of Immunology (Baltimore, Md. : 1950). 182: 7430-9. PMID 19494266 DOI: 10.4049/Jimmunol.0900039  0.76
2009 Duncan GE, Inada K, Farrington JS, Koller BH, Moy SS. Neural activation deficits in a mouse genetic model of NMDA receptor hypofunction in tests of social aggression and swim stress. Brain Research. 1265: 186-95. PMID 19232330 DOI: 10.1016/J.Brainres.2009.02.002  0.76
2009 Németh K, Leelahavanichkul A, Yuen PS, Mayer B, Parmelee A, Doi K, Robey PG, Leelahavanichkul K, Koller BH, Brown JM, Hu X, Jelinek I, Star RA, Mezey E. Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nature Medicine. 15: 42-9. PMID 19098906 DOI: 10.1038/Nm.1905  0.76
2009 Jania LA, Chandrasekharan S, Backlund MG, Foley NA, Snouwaert J, Wang IM, Clark P, Audoly LP, Koller BH. Microsomal prostaglandin E synthase-2 is not essential for in vivo prostaglandin E2 biosynthesis. Prostaglandins & Other Lipid Mediators. 88: 73-81. PMID 19010439 DOI: 10.1016/J.Prostaglandins.2008.10.003  0.76
2009 Németh K, Leelahavanichkul A, Yuen PST, Mayer B, Parmelee A, Doi K, Robey PG, Leelahavanichkul K, Koller BH, Brown JM, Hu X, Jelinek I, Star RA, Mezey E. Reply to 'Mesenchymal stem cells: Another anti-inflammatory treatment for sepsis?' Nature Medicine. 15: 602. DOI: 10.1038/Nm0609-602A  0.76
2008 Duncan GE, Inada K, Farrington JS, Koller BH. Seizure responses and induction of Fos by the NMDA agonist (tetrazol-5-yl)glycine in a genetic model of NMDA receptor hypofunction. Brain Research. 1221: 41-8. PMID 18550035 DOI: 10.1016/J.Brainres.2008.05.001  0.76
2008 Coggins KG, Coffman TM, Koller BH. The Hippocratic finger points the blame at PGE2. Nature Genetics. 40: 691-2. PMID 18509311 DOI: 10.1038/Ng0608-691  0.76
2008 Sul OJ, Lee HW, Kim WK, Choi JH, Kwak JS, Choi YJ, Latour AM, Koller BH, Jeong CS, Kwon BS. Regulation of the murine TR2/HVEM gene expression by IRF. Biochemical and Biophysical Research Communications. 367: 277-83. PMID 18155158 DOI: 10.1016/J.Bbrc.2007.12.071  0.76
2008 Moy SS, Nadler JJ, Poe MD, Nonneman RJ, Young NB, Koller BH, Crawley JN, Duncan GE, Bodfish JW. Development of a mouse test for repetitive, restricted behaviors: relevance to autism. Behavioural Brain Research. 188: 178-94. PMID 18068825 DOI: 10.1016/J.Bbr.2007.10.029  0.76
2007 Nguyen M, Pace AJ, Koller BH. Mice lacking NKCC1 are protected from development of bacteremia and hypothermic sepsis secondary to bacterial pneumonia. The Journal of Experimental Medicine. 204: 1383-93. PMID 17517966 DOI: 10.1084/Jem.20061205  0.76
2007 Francois H, Facemire C, Kumar A, Audoly L, Koller B, Coffman T. Role of microsomal prostaglandin E synthase 1 in the kidney. Journal of the American Society of Nephrology : Jasn. 18: 1466-75. PMID 17442791 DOI: 10.1681/Asn.2006040343  0.76
2007 Lovgren AK, Kovarova M, Koller BH. cPGES/p23 is required for glucocorticoid receptor function and embryonic growth but not prostaglandin E2 synthesis. Molecular and Cellular Biology. 27: 4416-30. PMID 17438133 DOI: 10.1128/Mcb.02314-06  0.76
2007 Ledford JG, Kovarova M, Koller BH. Impaired host defense in mice lacking ONZIN. Journal of Immunology (Baltimore, Md. : 1950). 178: 5132-43. PMID 17404296 DOI: 10.4049/Jimmunol.178.8.5132  0.76
2007 Inada K, Farrington JS, Moy SS, Koller BH, Duncan GE. Assessment of NMDA receptor activation in vivo by Fos induction after challenge with the direct NMDA agonist (tetrazol-5-yl)glycine: effects of clozapine and haloperidol. Journal of Neural Transmission (Vienna, Austria : 1996). 114: 899-908. PMID 17318306 DOI: 10.1007/S00702-007-0628-5  0.76
2007 Tilley SL, Jaradat M, Stapleton C, Dixon D, Hua X, Erikson CJ, McCaskill JG, Chason KD, Liao G, Jania L, Koller BH, Jetten AM. Retinoid-related orphan receptor gamma controls immunoglobulin production and Th1/Th2 cytokine balance in the adaptive immune response to allergen. Journal of Immunology (Baltimore, Md. : 1950). 178: 3208-18. PMID 17312169 DOI: 10.4049/Jimmunol.178.5.3208  0.76
2007 Hua X, Kovarova M, Chason KD, Nguyen M, Koller BH, Tilley SL. Enhanced mast cell activation in mice deficient in the A2b adenosine receptor. The Journal of Experimental Medicine. 204: 117-28. PMID 17200408 DOI: 10.1084/Jem.20061372032807C  0.76
2007 Qi J, Chi L, Faber J, Koller B, Banes AJ. ATP reduces gel compaction in osteoblast-populated collagen gels. Journal of Applied Physiology (Bethesda, Md. : 1985). 102: 1152-60. PMID 17122380 DOI: 10.1152/Japplphysiol.00535.2006  0.76
2006 Cressman VL, Backlund DC, Avrutskaya AV, Leadon SA, Godfrey V, Koller BH. Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice. Molecular and Cellular Biology. 26: 9571. PMID 17135280 DOI: 10.1128/Mcb.01939-06  0.76
2006 Duncan GE, Moy SS, Lieberman JA, Koller BH. Typical and atypical antipsychotic drug effects on locomotor hyperactivity and deficits in sensorimotor gating in a genetic model of NMDA receptor hypofunction. Pharmacology, Biochemistry, and Behavior. 85: 481-91. PMID 17097724 DOI: 10.1016/J.Pbb.2006.09.017  0.76
2006 Allen IC, Pace AJ, Jania LA, Ledford JG, Latour AM, Snouwaert JN, Bernier V, Stocco R, Therien AG, Koller BH. Expression and function of NPSR1/GPRA in the lung before and after induction of asthma-like disease. American Journal of Physiology. Lung Cellular and Molecular Physiology. 291: L1005-17. PMID 16829631 DOI: 10.1152/Ajplung.00174.2006  0.76
2006 Biswas S, Bhattacherjee P, Paterson C, Tilley S, Koller B. Ocular inflammatory responses in the EP2 and EP4 receptor knockout mice Ocular Immunology and Inflammation. 14: 157-163. PMID 16766399 DOI: 10.1080/09273940600665879  0.76
2006 Moy SS, Perez A, Koller BH, Duncan GE. Amphetamine-induced disruption of prepulse inhibition in mice with reduced NMDA receptor function. Brain Research. 1089: 186-94. PMID 16638606 DOI: 10.1016/J.Brainres.2006.03.073  0.76
2006 Lovgren AK, Jania LA, Hartney JM, Parsons KK, Audoly LP, Fitzgerald GA, Tilley SL, Koller BH. COX-2-derived prostacyclin protects against bleomycin-induced pulmonary fibrosis. American Journal of Physiology. Lung Cellular and Molecular Physiology. 291: L144-56. PMID 16473862 DOI: 10.1152/Ajplung.00492.2005  0.76
2006 Duncan GE, Moy SS, Lieberman JA, Koller BH. Effects of haloperidol, clozapine, and quetiapine on sensorimotor gating in a genetic model of reduced NMDA receptor function. Psychopharmacology. 184: 190-200. PMID 16362405 DOI: 10.1007/S00213-005-0214-1  0.76
2006 Parsons KK, Maeda N, Yamauchi M, Banes AJ, Koller BH. Ascorbic acid-independent synthesis of collagen in mice. American Journal of Physiology. Endocrinology and Metabolism. 290: E1131-9. PMID 16352673 DOI: 10.1152/Ajpendo.00339.2005  0.76
2006 Allen IC, Hartney JM, Coffman TM, Penn RB, Wess J, Koller BH. Thromboxane A2 induces airway constriction through an M3 muscarinic acetylcholine receptor-dependent mechanism. American Journal of Physiology. Lung Cellular and Molecular Physiology. 290: L526-33. PMID 16243899 DOI: 10.1152/Ajplung.00340.2005  0.76
2006 Hartney JM, Coggins KG, Tilley SL, Jania LA, Lovgren AK, Audoly LP, Koller BH. Prostaglandin E2 protects lower airways against bronchoconstriction. American Journal of Physiology. Lung Cellular and Molecular Physiology. 290: L105-13. PMID 16113047 DOI: 10.1152/Ajplung.00221.2005  0.76
2006 Banes AJ, Fox AM, Qi J, Koller B. The role of P2Y1 and P2Y2 purinoceptors in determining mechanosensitivity in connective tissue cells McB Molecular and Cellular Biomechanics. 3: 211. DOI: 10.1016/S0021-9290(06)83116-7  0.76
2005 Nguyen M, Pace AJ, Koller BH. Age-induced reprogramming of mast cell degranulation. Journal of Immunology (Baltimore, Md. : 1950). 175: 5701-7. PMID 16237060 DOI: 10.4049/Jimmunol.175.9.5701  0.76
2005 Chandrasekharan S, Foley NA, Jania L, Clark P, Audoly LP, Koller BH. Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary gland. Journal of Lipid Research. 46: 2636-48. PMID 16204198 DOI: 10.1194/Jlr.M500213-Jlr200  0.76
2005 Francois H, Athirakul K, Howell D, Dash R, Mao L, Kim HS, Rockman HA, Fitzgerald GA, Koller BH, Coffman TM. Prostacyclin protects against elevated blood pressure and cardiac fibrosis. Cell Metabolism. 2: 201-7. PMID 16154102 DOI: 10.1016/J.Cmet.2005.08.005  0.76
2005 McDaniel N, Pace AJ, Spiegel S, Engelhardt R, Koller BH, Seidler U, Lytle C. Role of Na-K-2Cl cotransporter-1 in gastric secretion of nonacidic fluid and pepsinogen. American Journal of Physiology. Gastrointestinal and Liver Physiology. 289: G550-60. PMID 16093421 DOI: 10.1152/Ajpgi.00095.2005  0.76
2005 Rocha PN, Plumb TJ, Robinson LA, Spurney R, Pisetsky D, Koller BH, Coffman TM. Role of thromboxane A2 in the induction of apoptosis of immature thymocytes by lipopolysaccharide. Clinical and Diagnostic Laboratory Immunology. 12: 896-903. PMID 16085905 DOI: 10.1128/Cdli.12.8.896-903.2005  0.76
2005 Cabuy E, Newton C, Joksic G, Woodbine L, Koller B, Jeggo PA, Slijepcevic P. Accelerated telomere shortening and telomere abnormalities in radiosensitive cell lines. Radiation Research. 164: 53-62. PMID 15966765 DOI: 10.1667/Rr3376  0.76
2005 Gu P, Goodwin B, Chung AC, Xu X, Wheeler DA, Price RR, Galardi C, Peng L, Latour AM, Koller BH, Gossen J, Kliewer SA, Cooney AJ. Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development. Molecular and Cellular Biology. 25: 3492-505. PMID 15831456 DOI: 10.1128/Mcb.25.9.3492-3505.2005  0.76
2005 Francois H, Athirakul K, Howell D, Dash R, Mao L, Kim HS, Rockman HA, FitzGerald GA, Koller BH, Coffman TM. NSAIDs and cardiovascular risk - Reply [2] Cell Metabolism. 2: 339-340. DOI: 10.1016/j.cmet.2005.11.009  0.76
2004 Egan KM, Lawson JA, Fries S, Koller B, Rader DJ, Smyth EM, Fitzgerald GA. COX-2-derived prostacyclin confers atheroprotection on female mice. Science (New York, N.Y.). 306: 1954-7. PMID 15550624 DOI: 10.1126/Science.1103333  0.76
2004 Miyamoto S, Snouwaert JN, Koller BH, Moy SS, Lieberman JA, Duncan GE. Amphetamine-induced Fos is reduced in limbic cortical regions but not in the caudate or accumbens in a genetic model of NMDA receptor hypofunction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 2180-8. PMID 15467708 DOI: 10.1038/Sj.Npp.1300548  0.76
2004 Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS, Dove WF, Duyk G, Dymecki S, Eppig JT, Grieder FB, Heintz N, Hicks G, Insel TR, Joyner A, ... Koller BH, et al. The knockout mouse project. Nature Genetics. 36: 921-4. PMID 15340423 DOI: 10.1038/Ng0904-921  0.76
2004 Duncan GE, Moy SS, Perez A, Eddy DM, Zinzow WM, Lieberman JA, Snouwaert JN, Koller BH. Deficits in sensorimotor gating and tests of social behavior in a genetic model of reduced NMDA receptor function. Behavioural Brain Research. 153: 507-19. PMID 15265649 DOI: 10.1016/J.Bbr.2004.01.008  0.76
2004 Goulet JL, Pace AJ, Key ML, Byrum RS, Nguyen M, Tilley SL, Morham SG, Langenbach R, Stock JL, McNeish JD, Smithies O, Coffman TM, Koller BH. E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation. Journal of Immunology (Baltimore, Md. : 1950). 173: 1321-6. PMID 15240726 DOI: 10.4049/Jimmunol.173.2.1321  0.76
2003 Thomas DW, Rocha PN, Nataraj C, Robinson LA, Spurney RF, Koller BH, Coffman TM. Proinflammatory actions of thromboxane receptors to enhance cellular immune responses. Journal of Immunology (Baltimore, Md. : 1950). 171: 6389-95. PMID 14662837 DOI: 10.4049/Jimmunol.171.12.6389  0.76
2003 Andre P, Delaney SM, LaRocca T, Vincent D, DeGuzman F, Jurek M, Koller B, Phillips DR, Conley PB. P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries. The Journal of Clinical Investigation. 112: 398-406. PMID 12897207 DOI: 10.1172/Jci17864  0.76
2003 Tilley SL, Tsai M, Williams CM, Wang ZS, Erikson CJ, Galli SJ, Koller BH. Identification of A3 receptor- and mast cell-dependent and -independent components of adenosine-mediated airway responsiveness in mice. Journal of Immunology (Baltimore, Md. : 1950). 171: 331-7. PMID 12817015 DOI: 10.4049/jimmunol.171.1.331  0.76
2003 Gowen LC, Avrutskaya AV, Latour AM, Koller BH, Leadon SA. Retraction. Science (New York, N.Y.). 300: 1657. PMID 12805518 DOI: 10.1126/science.300.5626.1657b  0.76
2003 Tilley SL, Hartney JM, Erikson CJ, Jania C, Nguyen M, Stock J, McNeisch J, Valancius C, Panettieri RA, Penn RB, Koller BH. Receptors and pathways mediating the effects of prostaglandin E2 on airway tone. American Journal of Physiology. Lung Cellular and Molecular Physiology. 284: L599-606. PMID 12618422 DOI: 10.1152/Ajplung.00324.2002  0.76
2003 Jiang J, Song Y, Bai C, Koller BH, Matthay MA, Verkman AS. Pleural surface fluorescence measurement of Na+ and Cl- transport across the air space-capillary barrier. Journal of Applied Physiology (Bethesda, Md. : 1985). 94: 343-52. PMID 12391048 DOI: 10.1152/Japplphysiol.00562.2002  0.76
2002 Bhattacherjee P, Mukhopadhyay P, Tilley SL, Koller BH, Geoghgan T, Paterson CA. Blood-aqueous barrier in prostaglandin EP2 receptor knockout mice. Ocular Immunology and Inflammation. 10: 187-96. PMID 12789594 DOI: 10.1076/Ocii.  0.76
2002 Nguyen M, Solle M, Audoly LP, Tilley SL, Stock JL, McNeish JD, Coffman TM, Dombrowicz D, Koller BH. Receptors and signaling mechanisms required for prostaglandin E2-mediated regulation of mast cell degranulation and IL-6 production. Journal of Immunology (Baltimore, Md. : 1950). 169: 4586-93. PMID 12370397 DOI: 10.4049/Jimmunol.169.8.4586  0.76
2002 Duncan G, Miyamoto S, Gu H, Lieberman J, Koller B, Snouwaert J. Alterations in regional brain metabolism in genetic and pharmacological models of reduced NMDA receptor function. Brain Research. 951: 166-76. PMID 12270494 DOI: 10.1016/S0006-8993(02)03156-6  0.76
2002 Fabre JE, Goulet JL, Riche E, Nguyen M, Coggins K, Offenbacher S, Koller BH. Transcellular biosynthesis contributes to the production of leukotrienes during inflammatory responses in vivo. The Journal of Clinical Investigation. 109: 1373-80. PMID 12021253 DOI: 10.1172/Jci14869  0.76
2002 Andrews HN, Mullan PB, McWilliams S, Sebelova S, Quinn JE, Gilmore PM, McCabe N, Pace A, Koller B, Johnston PG, Haber DA, Harkin DP. BRCA1 regulates the interferon gamma-mediated apoptotic response. The Journal of Biological Chemistry. 277: 26225-32. PMID 12011077 DOI: 10.1074/Jbc.M201316200  0.76
2002 Coggins KG, Latour A, Nguyen MS, Audoly L, Coffman TM, Koller BH. Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus. Nature Medicine. 8: 91-2. PMID 11821873 DOI: 10.1038/Nm0202-91  0.76
2001 Goulet JL, Griffiths RC, Ruiz P, Mannon RB, Flannery P, Platt JL, Koller BH, Coffman TM. Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice. Journal of Immunology (Baltimore, Md. : 1950). 167: 6631-6. PMID 11714834 DOI: 10.4049/Jimmunol.167.11.6631  0.76
2001 Nataraj C, Thomas DW, Tilley SL, Nguyen M, Mannon R, Koller BH, Coffman TM. Receptors for prostaglandin E2 that regulate cellular immune responses in the mouse Journal of Clinical Investigation. 108: 1229-1235. PMID 11602631 DOI: 10.1172/Jci13640  0.76
2001 Backlund MG, Trasti SL, Backlund DC, Cressman VL, Godfrey V, Koller BH. Impact of ionizing radiation and genetic background on mammary tumorigenesis in p53-deficient mice. Cancer Research. 61: 6577-82. PMID 11522657  0.76
2001 Gillie DJ, Pace AJ, Coakley RJ, Koller BH, Barker PM. Liquid and ion transport by fetal airway and lung epithelia of mice deficient in sodium-potassium-2-chloride transporter. American Journal of Respiratory Cell and Molecular Biology. 25: 14-20. PMID 11472970 DOI: 10.1165/Ajrcmb.25.1.4500  0.76
2001 Grubb BR, Pace AJ, Lee E, Koller BH, Boucher RC. Alterations in airway ion transport in NKCC1-deficient mice. American Journal of Physiology. Cell Physiology. 281: C615-23. PMID 11443061 DOI: 10.1152/Ajpcell.2001.281.2.C615  0.76
2001 Tilley SL, Coffman TM, Koller BH. Mixed messages: Modulation of inflammation and immune responses by prostaglandins and thromboxanes Journal of Clinical Investigation. 108: 15-23. PMID 11435451 DOI: 10.1172/Jci13416  0.76
2001 Aprelikova O, Pace AJ, Fang B, Koller BH, Liu ET. BRCA1 is a selective co-activator of 14-3-3 sigma gene transcription in mouse embryonic stem cells. The Journal of Biological Chemistry. 276: 25647-50. PMID 11384963 DOI: 10.1074/Jbc.C100265200  0.76
2001 Pace AJ, Madden VJ, Henson OW, Koller BH, Henson MM. Ultrastructure of the inner ear of NKCC1-deficient mice. Hearing Research. 156: 17-30. PMID 11377879 DOI: 10.1016/S0378-5955(01)00263-5  0.76
2001 Staudinger JL, Goodwin B, Jones SA, Hawkins-Brown D, MacKenzie KI, LaTour A, Liu Y, Klaassen CD, Brown KK, Reinhard J, Willson TM, Koller BH, Kliewer SA. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proceedings of the National Academy of Sciences of the United States of America. 98: 3369-74. PMID 11248085 DOI: 10.1073/Pnas.051551698  0.76
2001 Loftin CD, Trivedi DB, Tiano HF, Clark JA, Lee CA, Epstein JA, Morham SG, Breyer MD, Nguyen M, Hawkins BM, Goulet JL, Smithies O, Koller BH, Langenbach R. Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2. Proceedings of the National Academy of Sciences of the United States of America. 98: 1059-64. PMID 11158594 DOI: 10.1073/Pnas.98.3.1059  0.76
2001 Audoly LP, Ruan X, Wagner VA, Goulet JL, Tilley SL, Koller BH, Coffman TM, Arendshorst WJ. Role of EP(2) and EP(3) PGE(2) receptors in control of murine renal hemodynamics. American Journal of Physiology. Heart and Circulatory Physiology. 280: H327-33. PMID 11123248 DOI: 10.1152/Ajpheart.2001.280.1.H327  0.76
2001 Fabre JE, King BF, Koller BH. Study of aggregation of platelets lacking the P2Y1 receptor Drug Development Research. 52: 150-155. DOI: 10.1002/Ddr.1109  0.76
2000 Grubb BR, Lee E, Pace AJ, Koller BH, Boucher RC. Intestinal ion transport in NKCC1-deficient mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. 279: G707-18. PMID 11005757 DOI: 10.1152/Ajpgi.2000.279.4.G707  0.76
2000 Goulet JL, Byrum RS, Key ML, Nguyen M, Wagoner VA, Koller BH. Genetic factors determine the contribution of leukotrienes to acute inflammatory responses. Journal of Immunology (Baltimore, Md. : 1950). 164: 4899-907. PMID 10779800 DOI: 10.4049/Jimmunol.164.9.4899  0.76
2000 Pace AJ, Lee E, Athirakul K, Coffman TM, O'Brien DA, Koller BH. Failure of spermatogenesis in mouse lines deficient in the Na(+)-K(+)-2Cl(-) cotransporter. The Journal of Clinical Investigation. 105: 441-50. PMID 10683373 DOI: 10.1172/Jci8553  0.76
2000 Salvatore CA, Tilley SL, Latour AM, Fletcher DS, Koller BH, Jacobson MA. Disruption of the A(3) adenosine receptor gene in mice and its effect on stimulated inflammatory cells. The Journal of Biological Chemistry. 275: 4429-34. PMID 10660615 DOI: 10.1074/Jbc.275.6.4429  0.32
1999 Snouwaert JN, Gowen LC, Latour AM, Mohn AR, Xiao A, DiBiase L, Koller BH. BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene. Oncogene. 18: 7900-7. PMID 10630642 DOI: 10.1038/Sj.Onc.1203334  0.32
1999 Mohn AR, Gainetdinov RR, Caron MG, Koller BH. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia Cell. 98: 427-436. PMID 10481908 DOI: 10.1016/S0092-8674(00)81972-8  0.76
1999 Cressman VL, Lazarowski E, Homolya L, Boucher RC, Koller BH, Grubb BR. Effect of loss of P2Y(2) receptor gene expression on nucleotide regulation of murine epithelial Cl(-) transport. The Journal of Biological Chemistry. 274: 26461-8. PMID 10473606 DOI: 10.1074/Jbc.274.37.26461  0.32
1999 Homolya L, Watt WC, Lazarowski ER, Koller BH, Boucher RC. Nucleotide-regulated calcium signaling in lung fibroblasts and epithelial cells from normal and P2Y(2) receptor (-/-) mice. The Journal of Biological Chemistry. 274: 26454-60. PMID 10473605 DOI: 10.1074/Jbc.274.37.26454  0.76
1998 Snouwaert JN, Gowen LC, Lee V, Koller BH. Characterization of Brca1 deficient mice. Breast Disease. 10: 33-44. PMID 15687547 DOI: 10.3233/Bd-1998-101-206  0.32
1998 Thomas DW, Mannon RB, Mannon PJ, Latour A, Oliver JA, Hoffman M, Smithies O, Koller BH, Coffman TM. Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2. The Journal of Clinical Investigation. 102: 1994-2001. PMID 9835625 DOI: 10.1172/Jci5116  0.76
1998 Gowen LC, Avrutskaya AV, Latour AM, Koller BH, Leadon SA. BRCA1 required for transcription-coupled repair of oxidative DNA damage. Science (New York, N.Y.). 281: 1009-12. PMID 9703501 DOI: 10.1126/Science.281.5379.1009  0.32
1997 Nguyen M, Camenisch T, Snouwaert JN, Hicks E, Coffman TM, Anderson PA, Malouf NN, Koller BH. The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth. Nature. 390: 78-81. PMID 9363893 DOI: 10.1038/36342  0.32
1997 Mohn AR, Feddersen RM, Nguyen MS, Koller BH. Phenotypic analysis of mice lacking the highly abundant Purkinje cell- and bipolar neuron-specific PCP2 protein Molecular and Cellular Neurosciences. 9: 63-76. PMID 9204480 DOI: 10.1006/Mcne.1997.0606  0.76
1997 Byrum RS, Goulet JL, Griffiths RJ, Koller BH. Role of the 5-lipoxygenase-activating protein (FLAP) in murine acute inflammatory responses. The Journal of Experimental Medicine. 185: 1065-75. PMID 9091580 DOI: 10.1084/Jem.185.6.1065  0.76
1996 Voelkel NF, Tuder RM, Wade K, Höper M, Lepley RA, Goulet JL, Koller BH, Fitzpatrick F. Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats. The Journal of Clinical Investigation. 97: 2491-8. PMID 8647941 DOI: 10.1172/Jci118696  0.76
1996 Gowen LC, Johnson BL, Latour AM, Sulik KK, Koller BH. Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nature Genetics. 12: 191-4. PMID 8563759 DOI: 10.1038/Ng0296-191  0.76
1995 Snouwaert JN, Brigman KK, Latour AM, Iraj E, Schwab U, Gilmour MI, Koller BH. A murine model of cystic fibrosis. American Journal of Respiratory and Critical Care Medicine. 151: S59-64. PMID 7533607 DOI: 10.1164/Ajrccm/151.3_Pt_2.S59  0.76
1994 Goulet JL, Snouwaert JN, Latour AM, Coffman TM, Koller BH. Altered inflammatory responses in leukotriene-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 91: 12852-6. PMID 7809134 DOI: 10.1073/Pnas.91.26.12852  0.76
1993 Desai NM, Bassiri H, Kim J, Koller BH, Smithies O, Barker CF, Naji A, Markmann JF. Islet allograft, islet xenograft, and skin allograft survival in CD8+ T lymphocyte-deficient mice. Transplantation. 55: 718-22. PMID 8475541 DOI: 10.1097/00007890-199304000-00006  0.76
1993 Desai NM, Bassiri H, Odorico JS, Koller BH, Smithies O, Naji A, Barker CF, Markmann JF. Pancreatic islet allograft and xenograft survival in CD8+ T-lymphocyte-deficient recipients. Transplantation Proceedings. 25: 961-2. PMID 8442280  0.76
1993 Coffman T, Geier S, Ibrahim S, Griffiths R, Spurney R, Smithies O, Koller B, Sanfilippo F. Improved renal function in mouse kidney allografts lacking MHC class I antigens. Journal of Immunology (Baltimore, Md. : 1950). 151: 425-35. PMID 8326135  0.76
1992 Spriggs MK, Koller BH, Sato T, Morrissey PJ, Fanslow WC, Smithies O, Voice RF, Widmer MB, Maliszewski CR. Beta 2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses. Proceedings of the National Academy of Sciences of the United States of America. 89: 6070-4. PMID 1631092 DOI: 10.1073/Pnas.89.13.6070  1
1992 Koller BH, Smithies O. Altering genes in animals by gene targeting. Annual Review of Immunology. 10: 705-30. PMID 1591000 DOI: 10.1146/Annurev.Iy.10.040192.003421  1
1992 Markmann JF, Bassiri H, Desai NM, Odorico JS, Kim JI, Koller BH, Smithies O, Barker CF. Indefinite survival of MHC class I-deficient murine pancreatic islet allografts. Transplantation. 54: 1085-9. PMID 1465773 DOI: 10.1097/00007890-199212000-00025  1
1992 Clarke LL, Grubb BR, Gabriel SE, Smithies O, Koller BH, Boucher RC. Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis. Science (New York, N.Y.). 257: 1125-8. PMID 1380724 DOI: 10.1126/Science.257.5073.1125  1
1992 Snouwaert JN, Brigman KK, Latour AM, Malouf NN, Boucher RC, Smithies O, Koller BH. An animal model for cystic fibrosis made by gene targeting. Science (New York, N.Y.). 257: 1083-8. PMID 1380723 DOI: 10.1126/Science.257.5073.1083  1
1992 Muller D, Koller BH, Whitton JL, Lapan KE, Brigman KK, Frelinger JA. LCMV-specific, class II-restricted cytotoxic T cells in β2-microglobulin-deficient mice Science. 255: 1576-1578. PMID 1347959 DOI: 10.1126/Science.1347959  0.76
1991 Koller BH, Kim HS, Latour AM, Brigman K, Boucher RC, Scambler P, Wainwright B, Smithies O. Toward an animal model of cystic fibrosis: targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 88: 10730-4. PMID 1720548 DOI: 10.1073/Pnas.88.23.10730  1
1990 Reid LH, Gregg RG, Smithies O, Koller BH. Regulatory elements in the introns of the human HPRT gene are necessary for its expression in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 87: 4299-303. PMID 2349238 DOI: 10.1073/Pnas.87.11.4299  0.76
1990 Koller BH, Marrack P, Kappler JW, Smithies O. Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. Science (New York, N.Y.). 248: 1227-30. PMID 2112266 DOI: 10.1126/Science.2112266  1
1990 Geraghty DE, Wei XH, Orr HT, Koller BH. Human leukocyte antigen F (HLA-F). An expressed HLA gene composed of a class I coding sequence linked to a novel transcribed repetitive element. The Journal of Experimental Medicine. 171: 1-18. PMID 1688605 DOI: 10.1084/Jem.171.1.1  0.76
1989 Koller BH, Smithies O. Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination. Proceedings of the National Academy of Sciences of the United States of America. 86: 8932-5. PMID 2682666 DOI: 10.1073/Pnas.86.22.8932  1
1989 Koller BH, Hagemann LJ, Doetschman T, Hagaman JR, Huang S, Williams PJ, First NL, Maeda N, Smithies O. Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 86: 8927-31. PMID 2573070 DOI: 10.1073/Pnas.86.22.8927  1
1989 Koller BH, Geraghty DE, DeMars R, Duvick L, Rich SS, Orr HT. Chromosomal organization of the human major histocompatibility complex class I gene family. The Journal of Experimental Medicine. 169: 469-80. PMID 2562983 DOI: 10.1084/Jem.169.2.469  0.76
1988 Shimizu Y, Geraghty DE, Koller BH, Orr HT, DeMars R. Transfer and expression of three cloned human non-HLA-A,B,C class I major histocompatibility complex genes in mutant lymphoblastoid cells. Proceedings of the National Academy of Sciences of the United States of America. 85: 227-31. PMID 3257565 DOI: 10.1073/Pnas.85.1.227  0.76
1987 Geraghty DE, Koller BH, Orr HT. A human major histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment. Proceedings of the National Academy of Sciences of the United States of America. 84: 9145-9. PMID 3480534 DOI: 10.1073/Pnas.84.24.9145  0.76
1987 Koller BH, Geraghty D, Orr HT, Shimizu Y, DeMars R. Organization of the human class I major histocompatibility complex genes. Immunologic Research. 6: 1-10. PMID 3040873 DOI: 10.1007/Bf02918100  0.76
1984 Koller BH, Sidwell B, DeMars R, Orr HT. Isolation of HLA locus-specific DNA probes from the 3'-untranslated region. Proceedings of the National Academy of Sciences of the United States of America. 81: 5175-8. PMID 6591185 DOI: 10.1073/Pnas.81.16.5175  0.76
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