James H. McKerrow - Publications

Affiliations: 
Biochemistry and Molecular Biology University of California, San Francisco, San Francisco, CA 
Area:
Biochemistry, Parasitology Biology

194 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Corvo I, Ferraro F, Merlino A, Zuberbühler K, O'Donoghue AJ, Pastro L, Pi-Denis N, Basika T, Roche L, McKerrow JH, Craik CS, Caffrey CR, Tort JF. Substrate Specificity of Cysteine Proteases Beyond the S Pocket: Mutagenesis and Molecular Dynamics Investigation of Cathepsins L. Frontiers in Molecular Biosciences. 5: 40. PMID 29725596 DOI: 10.3389/fmolb.2018.00040  0.48
2017 Long T, Rojo-Arreola L, Shi D, El-Sakkary N, Jarnagin K, Rock F, Meewan M, Rascón AA, Lin L, Cunningham KA, Lemieux GA, Podust L, Abagyan R, Ashrafi K, McKerrow JH, et al. Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target. Plos Neglected Tropical Diseases. 11: e0005680. PMID 28704396 DOI: 10.1371/journal.pntd.0005680  0.32
2016 Goupil LS, Ivry SL, Hsieh I, Suzuki BM, Craik CS, O'Donoghue AJ, McKerrow JH. Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria. Plos Neglected Tropical Diseases. 10: e0004893. PMID 27501047 DOI: 10.1371/journal.pntd.0004893  0.72
2016 Parsonage D, Sheng F, Hirata K, Debnath A, McKerrow JH, Reed SL, Abagyan R, Poole LB, Podust LM. X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action. Journal of Structural Biology. PMID 26876147 DOI: 10.1016/j.jsb.2016.02.015  0.72
2016 Jones BD, Tochowicz A, Tang Y, Cameron MD, McCall LI, Hirata K, Siqueira-Neto JL, Reed SL, McKerrow JH, Roush WR. Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain. Acs Medicinal Chemistry Letters. 7: 77-82. PMID 26819670 DOI: 10.1021/acsmedchemlett.5b00336  0.72
2016 Long T, Neitz RJ, Beasley R, Kalyanaraman C, Suzuki BM, Jacobson MP, Dissous C, McKerrow JH, Drewry DH, Zuercher WJ, Singh R, Caffrey CR. Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni. Plos Neglected Tropical Diseases. 10: e0004356. PMID 26751972 DOI: 10.1371/journal.pntd.0004356  0.72
2015 Urbina JA, McKerrow JH. Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs. Antimicrobial Agents and Chemotherapy. 59: 7923-4. PMID 26578701 DOI: 10.1128/AAC.01714-15  0.72
2015 Gaspar L, Moraes CB, Freitas-Junior LH, Ferrari S, Costantino L, Costi MP, Coron RP, Smith TK, Siqueira-Neto JL, McKerrow JH, Cordeiro-da-Silva A. Current and Future Chemotherapy For Chagas Disease. Current Medicinal Chemistry. PMID 26477622  0.72
2015 Schulze CJ, Donia MS, Siqueira-Neto JL, Ray D, Raskatov JA, Green RE, McKerrow JH, Fischbach MA, Linington RG. Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei. Acs Chemical Biology. PMID 26270237 DOI: 10.1021/acschembio.5b00308  0.72
2015 Avelar LA, Camilo CD, de Albuquerque S, Fernandes WB, Gonçalez C, Kenny PW, Leitão A, McKerrow JH, Montanari CA, Orozco EV, Ribeiro JF, Rocha JR, Rosini F, Saidel ME. Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors. Plos Neglected Tropical Diseases. 9: e0003916. PMID 26173110 DOI: 10.1371/journal.pntd.0003916  0.72
2015 Ekins S, Lage de Siqueira-Neto J, McCall LI, Sarker M, Yadav M, Ponder EL, Kallel EA, Kellar D, Chen S, Arkin M, Bunin BA, McKerrow JH, Talcott C. Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery. Plos Neglected Tropical Diseases. 9: e0003878. PMID 26114876 DOI: 10.1371/journal.pntd.0003878  0.72
2015 Fajtová P, Štefanić S, Hradilek M, Dvořák J, Vondrášek J, Jílková A, Ulrychová L, McKerrow JH, Caffrey CR, Mareš M, Horn M. Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors. Plos Neglected Tropical Diseases. 9: e0003827. PMID 26039195 DOI: 10.1371/journal.pntd.0003827  0.72
2015 Shahinas D, Debnath A, Benedict C, McKerrow JH, Pillai DR. Heat shock protein 90 inhibitors repurposed against Entamoeba histolytica. Frontiers in Microbiology. 6: 368. PMID 26029171 DOI: 10.3389/fmicb.2015.00368  0.72
2015 McCall LI, El Aroussi A, Choi JY, Vieira DF, De Muylder G, Johnston JB, Chen S, Kellar D, Siqueira-Neto JL, Roush WR, Podust LM, McKerrow JH. Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase. Plos Neglected Tropical Diseases. 9: e0003588. PMID 25768284 DOI: 10.1371/journal.pntd.0003588  0.72
2015 Fonseca NC, da Cruz LF, da Silva Villela F, do Nascimento Pereira GA, de Siqueira-Neto JL, Kellar D, Suzuki BM, Ray D, de Souza TB, Alves RJ, Sales Júnior PA, Romanha AJ, Murta SM, McKerrow JH, Caffrey CR, et al. Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1. Antimicrobial Agents and Chemotherapy. 59: 2666-77. PMID 25712353 DOI: 10.1128/AAC.04601-14  0.72
2015 Bulman CA, Bidlow CM, Lustigman S, Cho-Ngwa F, Williams D, Rascón AA, Tricoche N, Samje M, Bell A, Suzuki B, Lim KC, Supakorndej N, Supakorndej P, Wolfe AR, Knudsen GM, ... ... McKerrow JH, et al. Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. Plos Neglected Tropical Diseases. 9: e0003534. PMID 25700363 DOI: 10.1371/journal.pntd.0003534  0.72
2015 Zhou Y, Vedantham P, Lu K, Agudelo J, Carrion R, Nunneley JW, Barnard D, Pöhlmann S, McKerrow JH, Renslo AR, Simmons G. Protease inhibitors targeting coronavirus and filovirus entry. Antiviral Research. 116: 76-84. PMID 25666761 DOI: 10.1016/j.antiviral.2015.01.011  0.72
2014 Al Obeed OA, Alkhayal KA, Al Sheikh A, Zubaidi AM, Vaali-Mohammed MA, Boushey R, Mckerrow JH, Abdulla MH. Increased expression of tumor necrosis factor-α is associated with advanced colorectal cancer stages. World Journal of Gastroenterology : Wjg. 20: 18390-6. PMID 25561807 DOI: 10.3748/wjg.v20.i48.18390  0.72
2014 Jílková A, Horn M, Rezáčová P, Marešová L, Fajtová P, Brynda J, Vondrášek J, McKerrow JH, Caffrey CR, Mareš M. Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch. Structure (London, England : 1993). 22: 1786-98. PMID 25456815 DOI: 10.1016/j.str.2014.09.015  0.72
2014 Vieira DF, Choi JY, Calvet CM, Siqueira-Neto JL, Johnston JB, Kellar D, Gut J, Cameron MD, McKerrow JH, Roush WR, Podust LM. Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51. Journal of Medicinal Chemistry. 57: 10162-75. PMID 25393646 DOI: 10.1021/jm501568b  0.72
2014 Calvet CM, Vieira DF, Choi JY, Kellar D, Cameron MD, Siqueira-Neto JL, Gut J, Johnston JB, Lin L, Khan S, McKerrow JH, Roush WR, Podust LM. 4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency. Journal of Medicinal Chemistry. 57: 6989-7005. PMID 25101801 DOI: 10.1021/jm500448u  0.72
2014 McCall LI, McKerrow JH. Determinants of disease phenotype in trypanosomatid parasites. Trends in Parasitology. 30: 342-9. PMID 24946952 DOI: 10.1016/j.pt.2014.05.001  0.72
2014 Choi JY, Calvet CM, Vieira DF, Gunatilleke SS, Cameron MD, McKerrow JH, Podust LM, Roush WR. R-Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi. Acs Medicinal Chemistry Letters. 5: 434-9. PMID 24900854 DOI: 10.1021/ml500010m  0.72
2014 Dandapani S, Germain AR, Jewett I, le Quement S, Marie JC, Muncipinto G, Duvall JR, Carmody LC, Perez JR, Engel JC, Gut J, Kellar D, Siqueira-Neto JL, McKerrow JH, Kaiser M, et al. Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease. Acs Medicinal Chemistry Letters. 5: 149-53. PMID 24900788 DOI: 10.1021/ml400403u  0.72
2014 Debnath A, Shahinas D, Bryant C, Hirata K, Miyamoto Y, Hwang G, Gut J, Renslo AR, Pillai DR, Eckmann L, Reed SL, McKerrow JH. Hsp90 inhibitors as new leads to target parasitic diarrheal diseases. Antimicrobial Agents and Chemotherapy. 58: 4138-44. PMID 24820073 DOI: 10.1128/AAC.02576-14  0.72
2014 Horn M, Fajtová P, Rojo Arreola L, Ulrychová L, Bartošová-Sojková P, Franta Z, Protasio AV, Opavský D, Vondrášek J, McKerrow JH, Mareš M, Caffrey CR, Dvořák J. Trypsin- and Chymotrypsin-like serine proteases in schistosoma mansoni-- 'the undiscovered country'. Plos Neglected Tropical Diseases. 8: e2766. PMID 24676141 DOI: 10.1371/journal.pntd.0002766  0.72
2014 Debnath A, Tunac JB, Silva-Olivares A, Galindo-Gómez S, Shibayama M, McKerrow JH. In vitro efficacy of corifungin against Acanthamoeba castellanii trophozoites and cysts. Antimicrobial Agents and Chemotherapy. 58: 1523-8. PMID 24366747 DOI: 10.1128/AAC.02254-13  0.72
2013 Choi JY, Calvet CM, Gunatilleke SS, Ruiz C, Cameron MD, McKerrow JH, Podust LM, Roush WR. Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents. Journal of Medicinal Chemistry. 56: 7651-68. PMID 24079662 DOI: 10.1021/jm401067s  0.72
2013 Ndao M, Nath-Chowdhury M, Sajid M, Marcus V, Mashiyama ST, Sakanari J, Chow E, Mackey Z, Land KM, Jacobson MP, Kalyanaraman C, McKerrow JH, Arrowood MJ, Caffrey CR. A cysteine protease inhibitor rescues mice from a lethal Cryptosporidium parvum infection. Antimicrobial Agents and Chemotherapy. 57: 6063-73. PMID 24060869 DOI: 10.1128/AAC.00734-13  0.72
2013 Wiggers HJ, Rocha JR, Fernandes WB, Sesti-Costa R, Carneiro ZA, Cheleski J, da Silva AB, Juliano L, Cezari MH, Silva JS, McKerrow JH, Montanari CA. Non-peptidic cruzain inhibitors with trypanocidal activity discovered by virtual screening and in vitro assay. Plos Neglected Tropical Diseases. 7: e2370. PMID 23991231 DOI: 10.1371/journal.pntd.0002370  0.72
2013 Corvo I, O'Donoghue AJ, Pastro L, Pi-Denis N, Eroy-Reveles A, Roche L, McKerrow JH, Dalton JP, Craik CS, Caffrey CR, Tort JF. Dissecting the Active Site of the Collagenolytic Cathepsin L3 Protease of the Invasive Stage of Fasciola hepatica Plos Neglected Tropical Diseases. 7. PMID 23875031 DOI: 10.1371/journal.pntd.0002269  0.72
2013 Nishino M, Choy JW, Gushwa NN, Oses-Prieto JA, Koupparis K, Burlingame AL, Renslo AR, McKerrow JH, Taunton J. Hypothemicin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei Elife. 2013. PMID 23853713 DOI: 10.7554/eLife.00712  0.72
2013 Rascón AA, McKerrow JH. Synthetic and natural protease inhibitors provide insights into parasite development, virulence and pathogenesis Current Medicinal Chemistry. 20: 3078-3102. PMID 23514418 DOI: 10.2174/0929867311320250005  0.72
2013 Sanchez LM, Knudsen GM, Helbig C, De Muylder G, Mascuch SM, Mackey ZB, Gerwick L, Clayton C, McKerrow JH, Linington RG. Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei. Journal of Natural Products. 76: 630-41. PMID 23445522 DOI: 10.1021/np300834q  0.72
2013 Tejman-Yarden N, Miyamoto Y, Leitsch D, Santini J, Debnath A, Gut J, McKerrow JH, Reed SL, Eckmann L. A reprofiled drug, auranofin, is effective against metronidazole-resistant Giardia lamblia. Antimicrobial Agents and Chemotherapy. 57: 2029-35. PMID 23403423 DOI: 10.1128/AAC.01675-12  0.72
2013 McKerrow JH, Ingram J, Lopez-Quezada L. Cercarial Elastase (Schistosoma) Handbook of Proteolytic Enzymes. 3: 2646-2648. DOI: 10.1016/B978-0-12-382219-2.00585-8  0.72
2013 Caffrey CR, Britton C, McKerrow JH. Helminth Cysteine Proteases Handbook of Proteolytic Enzymes. 2: 1949-1957. DOI: 10.1016/B978-0-12-382219-2.00444-0  0.72
2013 Robinson MW, Brindley PJ, McKerrow JH, Dalton JP. Trematode Cysteine Endopeptidases Handbook of Proteolytic Enzymes. 2: 1941-1949. DOI: 10.1016/B978-0-12-382219-2.00443-9  0.72
2012 Mashiyama ST, Koupparis K, Caffrey CR, McKerrow JH, Babbitt PC. A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets. Plos Neglected Tropical Diseases. 6: e1942. PMID 23236535 DOI: 10.1371/journal.pntd.0001942  0.72
2012 Lee GM, Balouch E, Goetz DH, Lazic A, McKerrow JH, Craik CS. Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy. Biochemistry. 51: 10087-98. PMID 23181936 DOI: 10.1021/bi301305k  0.72
2012 Navarro G, Chokpaiboon S, De Muylder G, Bray WM, Nisam SC, McKerrow JH, Pudhom K, Linington RG. Hit-to-lead development of the chamigrane endoperoxide merulin A for the treatment of African sleeping sickness. Plos One. 7: e46172. PMID 23029428 DOI: 10.1371/journal.pone.0046172  0.72
2012 O'Donoghue AJ, Eroy-Reveles AA, Knudsen GM, Ingram J, Zhou M, Statnekov JB, Greninger AL, Hostetter DR, Qu G, Maltby DA, Anderson MO, Derisi JL, McKerrow JH, Burlingame AL, Craik CS. Global identification of peptidase specificity by multiplex substrate profiling. Nature Methods. 9: 1095-100. PMID 23023596 DOI: 10.1038/nmeth.2182  0.72
2012 dos Santos Filho JM, Moreira DR, de Simone CA, Ferreira RS, McKerrow JH, Meira CS, Guimarães ET, Soares MB. Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice. Bioorganic & Medicinal Chemistry. 20: 6423-33. PMID 23006639 DOI: 10.1016/j.bmc.2012.08.047  0.72
2012 Broadhurst MJ, Leung JM, Lim KC, Girgis NM, Gundra UM, Fallon PG, Premenko-Lanier M, McKerrow JH, McCune JM, Loke P. Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice. Plos Pathogens. 8: e1002883. PMID 22927819 DOI: 10.1371/journal.ppat.1002883  0.72
2012 Lavrado J, Mackey Z, Hansell E, McKerrow JH, Paulo A, Moreira R. Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives. Bioorganic & Medicinal Chemistry Letters. 22: 6256-60. PMID 22926067 DOI: 10.1016/j.bmcl.2012.07.104  0.72
2012 Debnath A, Tunac JB, Galindo-Gómez S, Silva-Olivares A, Shibayama M, McKerrow JH. Corifungin, a new drug lead against Naegleria, identified from a high-throughput screen. Antimicrobial Agents and Chemotherapy. 56: 5450-7. PMID 22869574 DOI: 10.1128/AAC.00643-12  0.72
2012 Gunatilleke SS, Calvet CM, Johnston JB, Chen CK, Erenburg G, Gut J, Engel JC, Ang KK, Mulvaney J, Chen S, Arkin MR, McKerrow JH, Podust LM. Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51. Plos Neglected Tropical Diseases. 6: e1736. PMID 22860142 DOI: 10.1371/journal.pntd.0001736  0.72
2012 Debnath A, Parsonage D, Andrade RM, He C, Cobo ER, Hirata K, Chen S, García-Rivera G, Orozco E, Martínez MB, Gunatilleke SS, Barrios AM, Arkin MR, Poole LB, McKerrow JH, et al. A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nature Medicine. 18: 956-60. PMID 22610278 DOI: 10.1038/nm.2758  0.72
2012 Sojka D, Franta Z, Frantová H, Bartosová P, Horn M, Váchová J, O'Donoghue AJ, Eroy-Reveles AA, Craik CS, Knudsen GM, Caffrey CR, McKerrow JH, Mares M, Kopácek P. Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1). The Journal of Biological Chemistry. 287: 21152-63. PMID 22539347 DOI: 10.1074/jbc.M112.347922  0.72
2012 Ingram JR, Rafi SB, Eroy-Reveles AA, Ray M, Lambeth L, Hsieh I, Ruelas D, Lim KC, Sakanari J, Craik CS, Jacobson MP, McKerrow JH. Investigation of the proteolytic functions of an expanded cercarial elastase gene family in Schistosoma mansoni. Plos Neglected Tropical Diseases. 6: e1589. PMID 22509414 DOI: 10.1371/journal.pntd.0001589  0.72
2012 Quezada LA, Sajid M, Lim KC, McKerrow JH. A blood fluke serine protease inhibitor regulates an endogenous larval elastase. The Journal of Biological Chemistry. 287: 7074-83. PMID 22174417 DOI: 10.1074/jbc.M111.313304  0.72
2012 Lustigman S, Mckerrow JH, Bottazzi ME. Vaccines Linked to Chemotherapy: A New Approach to Control Helminth Infections Parasitic Helminths: Targets, Screens, Drugs and Vaccines. 357-375. DOI: 10.1002/9783527652969.ch22  0.72
2011 Johnson TA, Sohn J, Inman WD, Estee SA, Loveridge ST, Vervoort HC, Tenney K, Liu J, Ang KK, Ratnam J, Bray WM, Gassner NC, Shen YY, Lokey RS, McKerrow JH, et al. Natural product libraries to accelerate the high-throughput discovery of therapeutic leads. Journal of Natural Products. 74: 2545-55. PMID 22129061 DOI: 10.1021/np200673b  0.72
2011 Abdulla MH, Lim KC, McKerrow JH, Caffrey CR. Proteomic identification of IPSE/alpha-1 as a major hepatotoxin secreted by Schistosoma mansoni eggs. Plos Neglected Tropical Diseases. 5: e1368. PMID 22039561 DOI: 10.1371/journal.pntd.0001368  0.72
2011 Doyle PS, Zhou YM, Hsieh I, Greenbaum DC, McKerrow JH, Engel JC. The Trypanosoma cruzi protease cruzain mediates immune evasion. Plos Pathogens. 7: e1002139. PMID 21909255 DOI: 10.1371/journal.ppat.1002139  0.72
2011 Jílková A, Rezácová P, Lepsík M, Horn M, Váchová J, Fanfrlík J, Brynda J, McKerrow JH, Caffrey CR, Mares M. Structural basis for inhibition of cathepsin B drug target from the human blood fluke, Schistosoma mansoni. The Journal of Biological Chemistry. 286: 35770-81. PMID 21832058 DOI: 10.1074/jbc.M111.271304  0.72
2011 Franta Z, Sojka D, Frantova H, Dvorak J, Horn M, Srba J, Talacko P, Mares M, Schneider E, Craik CS, McKerrow JH, Caffrey CR, Kopacek P. IrCL1 - the haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus. International Journal For Parasitology. 41: 1253-62. PMID 21819989 DOI: 10.1016/j.ijpara.2011.06.006  0.72
2011 De Muylder G, Ang KK, Chen S, Arkin MR, Engel JC, McKerrow JH. A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit. Plos Neglected Tropical Diseases. 5: e1253. PMID 21811648 DOI: 10.1371/journal.pntd.0001253  0.72
2011 Quezada LA, McKerrow JH. Schistosome serine protease inhibitors: parasite defense or homeostasis? Anais Da Academia Brasileira De CiêNcias. 83: 663-72. PMID 21670886  0.72
2011 Mackey ZB, Koupparis K, Nishino M, McKerrow JH. High-throughput analysis of an RNAi library identifies novel kinase targets in Trypanosoma brucei. Chemical Biology & Drug Design. 78: 454-63. PMID 21668652 DOI: 10.1111/j.1747-0285.2011.01156.x  0.72
2011 Sajid M, Robertson SA, Brinen LS, McKerrow JH. Cruzain : the path from target validation to the clinic. Advances in Experimental Medicine and Biology. 712: 100-15. PMID 21660661 DOI: 10.1007/978-1-4419-8414-2_7  0.72
2011 Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. Mining a cathepsin inhibitor library for new antiparasitic drug leads. Plos Neglected Tropical Diseases. 5: e1023. PMID 21572521 DOI: 10.1371/journal.pntd.0001023  0.72
2011 Gut J, Ang KK, Legac J, Arkin MR, Rosenthal PJ, McKerrow JH. An image-based assay for high throughput screening of Giardia lamblia. Journal of Microbiological Methods. 84: 398-405. PMID 21262276 DOI: 10.1016/j.mimet.2010.12.026  0.72
2011 Swenerton RK, Zhang S, Sajid M, Medzihradszky KF, Craik CS, Kelly BL, McKerrow JH. The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion. The Journal of Biological Chemistry. 286: 429-40. PMID 20961853 DOI: 10.1074/jbc.M110.138313  0.72
2011 Calcul L, Tenney K, Ratnam J, McKerrow JH, Crews P. Corrigendum to: Structural variations to the 9-n-methyladeninium Diterpeniod hybrid commonly isolated from agelas sponges isolated from Agelas sponges Australian Journal of Chemistry. 64: 915-921. DOI: 10.1071/CH10036-CO  0.72
2010 Ding D, Zhao Y, Meng Q, Xie D, Nare B, Chen D, Bacchi CJ, Yarlett N, Zhang YK, Hernandez V, Xia Y, Freund Y, Abdulla M, Ang KH, Ratnam J, ... McKerrow JH, et al. Discovery of novel benzoxaborole-based potent antitrypanosomal agents. Acs Medicinal Chemistry Letters. 1: 165-9. PMID 24900190 DOI: 10.1021/ml100013s  0.72
2010 Broadhurst MJ, Leung JM, Kashyap V, McCune JM, Mahadevan U, McKerrow JH, Loke P. IL-22+ CD4+ T cells are associated with therapeutic trichuris trichiura infection in an ulcerative colitis patient. Science Translational Medicine. 2: 60ra88. PMID 21123809 DOI: 10.1126/scitranslmed.3001500  0.72
2010 Stefanić S, Dvořák J, Horn M, Braschi S, Sojka D, Ruelas DS, Suzuki B, Lim KC, Hopkins SD, McKerrow JH, Caffrey CR. RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening. Plos Neglected Tropical Diseases. 4: e850. PMID 20976050 DOI: 10.1371/journal.pntd.0000850  0.72
2010 Hernandes MZ, Rabello MM, Leite AC, Cardoso MV, Moreira DR, Brondani DJ, Simone CA, Reis LC, Souza MA, Pereira VR, Ferreira RS, McKerrow JH. Studies toward the structural optimization of novel thiazolylhydrazone-based potent antitrypanosomal agents. Bioorganic & Medicinal Chemistry. 18: 7826-35. PMID 20961766 DOI: 10.1016/j.bmc.2010.09.056  0.72
2010 Chen YT, Brinen LS, Kerr ID, Hansell E, Doyle PS, McKerrow JH, Roush WR. In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. Plos Neglected Tropical Diseases. 4. PMID 20856868 DOI: 10.1371/journal.pntd.0000825  0.72
2010 Swenerton RK, Knudsen GM, Sajid M, Kelly BL, McKerrow JH. Leishmania subtilisin is a maturase for the trypanothione reductase system and contributes to disease pathology. The Journal of Biological Chemistry. 285: 31120-9. PMID 20675366 DOI: 10.1074/jbc.M110.114462  0.72
2010 Engel JC, Ang KK, Chen S, Arkin MR, McKerrow JH, Doyle PS. Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease. Antimicrobial Agents and Chemotherapy. 54: 3326-34. PMID 20547819 DOI: 10.1128/AAC.01777-09  0.72
2010 Ferreira RS, Simeonov A, Jadhav A, Eidam O, Mott BT, Keiser MJ, McKerrow JH, Maloney DJ, Irwin JJ, Shoichet BK. Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors. Journal of Medicinal Chemistry. 53: 4891-905. PMID 20540517 DOI: 10.1021/jm100488w  0.72
2010 Chen CK, Leung SS, Guilbert C, Jacobson MP, McKerrow JH, Podust LM. Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole. Plos Neglected Tropical Diseases. 4: e651. PMID 20386598 DOI: 10.1371/journal.pntd.0000651  0.72
2010 Doyle PS, Chen CK, Johnston JB, Hopkins SD, Leung SS, Jacobson MP, Engel JC, McKerrow JH, Podust LM. A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection. Antimicrobial Agents and Chemotherapy. 54: 2480-8. PMID 20385875 DOI: 10.1128/AAC.00281-10  0.72
2010 Zhang S, Kim CC, Batra S, McKerrow JH, Loke P. Delineation of diverse macrophage activation programs in response to intracellular parasites and cytokines. Plos Neglected Tropical Diseases. 4: e648. PMID 20361029 DOI: 10.1371/journal.pntd.0000648  0.72
2010 Calcul L, Inman WD, Morris AA, Tenney K, Ratnam J, McKerrow JH, Valeriote FA, Crews P. Additional insights on the bastadins: Isolation of analogues from the sponge ianthella cf. reticulata and exploration of the oxime configurations Journal of Natural Products. 73: 365-372. PMID 20102170 DOI: 10.1021/np9005986  0.72
2010 Brak K, Kerr ID, Barrett KT, Fuchi N, Debnath M, Ang K, Engel JC, McKerrow JH, Doyle PS, Brinen LS, Ellman JA. Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy. Journal of Medicinal Chemistry. 53: 1763-73. PMID 20088534 DOI: 10.1021/jm901633v  0.72
2010 Dvorák J, Beckmann S, Lim KC, Engel JC, Grevelding CG, McKerrow JH, Caffrey CR. Biolistic transformation of Schistosoma mansoni: Studies with modified reporter-gene constructs containing regulatory regions of protease genes. Molecular and Biochemical Parasitology. 170: 37-40. PMID 19914302 DOI: 10.1016/j.molbiopara.2009.11.001  0.72
2010 Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR, McKerrow JH, Inglese J, Austin CP, Thomas CJ, Shoichet BK, et al. Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. Journal of Medicinal Chemistry. 53: 52-60. PMID 19908842 DOI: 10.1021/jm901069a  0.72
2010 Calcul L, Tenney K, Ratnam J, McKerrow JH, Crews P. Structural variations to the 9-N-methyladeninium diterpenoid hybrid commonly isolated from agelas sponges Australian Journal of Chemistry. 63: 915-921. DOI: 10.1071/CH10036  0.72
2009 Ovat A, Muindi F, Fagan C, Brouner M, Hansell E, Dvorák J, Sojka D, Kopácek P, McKerrow JH, Caffrey CR, Powers JC. Aza-peptidyl Michael acceptor and epoxide inhibitors--potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases). Journal of Medicinal Chemistry. 52: 7192-210. PMID 19848405 DOI: 10.1021/jm900849h  0.72
2009 Bryant C, Kerr ID, Debnath M, Ang KK, Ratnam J, Ferreira RS, Jaishankar P, Zhao D, Arkin MR, McKerrow JH, Brinen LS, Renslo AR. Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorganic & Medicinal Chemistry Letters. 19: 6218-21. PMID 19773167 DOI: 10.1016/j.bmcl.2009.08.098  0.72
2009 Mallari JP, Shelat AA, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK. Structure-guided development of selective TbcatB inhibitors. Journal of Medicinal Chemistry. 52: 6489-93. PMID 19769357 DOI: 10.1021/jm900908p  0.72
2009 Mckerrow JH, Doyle PS, Engel JC, Podust LM, Robertson SA, Ferreira R, Saxton T, Arkin M, Kerr ID, Brinen LS, Craik CS. Two approaches to discovering and developing new drugs for Chagas disease Memorias Do Instituto Oswaldo Cruz. 104: 263-269. PMID 19753483  0.72
2009 Abodeely M, DuBois KN, Hehl A, Stefanic S, Sajid M, DeSouza W, Attias M, Engel JC, Hsieh I, Fetter RD, McKerrow JH. A contiguous compartment functions as endoplasmic reticulum and endosome/lysosome in Giardia lamblia. Eukaryotic Cell. 8: 1665-76. PMID 19749174 DOI: 10.1128/EC.00123-09  0.72
2009 Arico-Muendel C, Centrella PA, Contonio BD, Morgan BA, O'Donovan G, Paradise CL, Skinner SR, Sluboski B, Svendsen JL, White KF, Debnath A, Gut J, Wilson N, McKerrow JH, DeRisi JL, et al. Antiparasitic activities of novel, orally available fumagillin analogs. Bioorganic & Medicinal Chemistry Letters. 19: 5128-31. PMID 19648008 DOI: 10.1016/j.bmcl.2009.07.029  0.72
2009 Ferreira RS, Bryant C, Ang KK, McKerrow JH, Shoichet BK, Renslo AR. Divergent modes of enzyme inhibition in a homologous structure-activity series. Journal of Medicinal Chemistry. 52: 5005-8. PMID 19637873 DOI: 10.1021/jm9009229  0.72
2009 Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey CR, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS. Vinyl sulfones as antiparasitic agents and a structural basis for drug design. The Journal of Biological Chemistry. 284: 25697-703. PMID 19620707 DOI: 10.1074/jbc.M109.014340  0.72
2009 Abdulla MH, Ruelas DS, Wolff B, Snedecor J, Lim KC, Xu F, Renslo AR, Williams J, McKerrow JH, Caffrey CR. Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening. Plos Neglected Tropical Diseases. 3: e478. PMID 19597541 DOI: 10.1371/journal.pntd.0000478  0.72
2009 Dvorák J, Mashiyama ST, Sajid M, Braschi S, Delcroix M, Schneider EL, McKerrow WH, Bahgat M, Hansell E, Babbitt PC, Craik CS, McKerrow JH, Caffrey CR. SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni. Plos Neglected Tropical Diseases. 3: e449. PMID 19488406 DOI: 10.1371/journal.pntd.0000449  0.72
2009 Johnson TA, Amagata T, Sashidhara KV, Oliver AG, Tenney K, Matainaho T, Ang KK, McKerrow JH, Crews P. The aignopsanes, a new class of sesquiterpenes from selected chemotypes of the sponge Cacospongia mycofijiensis. Organic Letters. 11: 1975-8. PMID 19385671 DOI: 10.1021/ol900446d  0.72
2009 Balsitis SJ, Coloma J, Castro G, Alava A, Flores D, McKerrow JH, Beatty PR, Harris E. Tropism of dengue virus in mice and humans defined by viral nonstructural protein 3-specific immunostaining. The American Journal of Tropical Medicine and Hygiene. 80: 416-24. PMID 19270292  0.72
2009 Caffrey CR, Rohwer A, Oellien F, Marhöfer RJ, Braschi S, Oliveira G, McKerrow JH, Selzer PM. A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni. Plos One. 4: e4413. PMID 19198654 DOI: 10.1371/journal.pone.0004413  0.72
2009 Chen CK, Doyle PS, Yermalitskaya LV, Mackey ZB, Ang KK, McKerrow JH, Podust LM. Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit. Plos Neglected Tropical Diseases. 3: e372. PMID 19190730 DOI: 10.1371/journal.pntd.0000372  0.72
2009 Rubio BK, Tenney K, Ang KH, Abdulla M, Arkin M, McKerrow JH, Crews P. The marine sponge Diacarnus bismarckensis as a source of peroxiterpene inhibitors of Trypanosoma brucei, the causative agent of sleeping sickness Journal of Natural Products. 72: 218-222. PMID 19159277 DOI: 10.1021/np800711a  0.72
2008 McKerrow JH, Rosenthal PJ, Swenerton R, Doyle P. Development of protease inhibitors for protozoan infections. Current Opinion in Infectious Diseases. 21: 668-72. PMID 18978536 DOI: 10.1097/QCO.0b013e328315cca9  0.72
2008 Abdulla MH, O'Brien T, Mackey ZB, Sajid M, Grab DJ, McKerrow JH. RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model. Plos Neglected Tropical Diseases. 2: e298. PMID 18820745 DOI: 10.1371/journal.pntd.0000298  0.72
2008 O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey CR, McKerrow JH. A parasite cysteine protease is key to host protein degradation and iron acquisition. The Journal of Biological Chemistry. 283: 28934-43. PMID 18701454 DOI: 10.1074/jbc.M805824200  0.72
2008 Fricker SP, Mosi RM, Cameron BR, Baird I, Zhu Y, Anastassov V, Cox J, Doyle PS, Hansell E, Lau G, Langille J, Olsen M, Qin L, Skerlj R, Wong RS, ... ... McKerrow JH, et al. Metal compounds for the treatment of parasitic diseases. Journal of Inorganic Biochemistry. 102: 1839-45. PMID 18684510 DOI: 10.1016/j.jinorgbio.2008.05.010  0.72
2008 Hansell E, Braschi S, Medzihradszky KF, Sajid M, Debnath M, Ingram J, Lim KC, McKerrow JH. Proteomic analysis of skin invasion by blood fluke larvae. Plos Neglected Tropical Diseases. 2: e262. PMID 18629379 DOI: 10.1371/journal.pntd.0000262  0.72
2008 Chen YT, Lira R, Hansell E, McKerrow JH, Roush WR. Synthesis of macrocyclic trypanosomal cysteine protease inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 5860-3. PMID 18585034 DOI: 10.1016/j.bmcl.2008.06.012  0.72
2008 Kongkerd N, Uparanukraw P, Morakote N, Sajid M, McKerrow JH. Identification and characterization of a cathepsin L-like cysteine protease from Gnathostoma spinigerum. Molecular and Biochemical Parasitology. 160: 129-37. PMID 18554733 DOI: 10.1016/j.molbiopara.2008.05.001  0.72
2008 DuBois KN, Abodeely M, Sakanari J, Craik CS, Lee M, McKerrow JH, Sajid M. Identification of the major cysteine protease of Giardia and its role in encystation. The Journal of Biological Chemistry. 283: 18024-31. PMID 18445589 DOI: 10.1074/jbc.M802133200  0.72
2008 Brak K, Doyle PS, McKerrow JH, Ellman JA. Identification of a new class of nonpeptidic inhibitors of cruzain. Journal of the American Chemical Society. 130: 6404-10. PMID 18435536 DOI: 10.1021/ja710254m  0.72
2008 Mallari JP, Shelat A, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK. Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB. Bioorganic & Medicinal Chemistry Letters. 18: 2883-5. PMID 18420405 DOI: 10.1016/j.bmcl.2008.03.083  0.72
2008 Götz MG, James KE, Hansell E, Dvorák J, Seshaadri A, Sojka D, Kopácek P, McKerrow JH, Caffrey CR, Powers JC. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. Journal of Medicinal Chemistry. 51: 2816-32. PMID 18416543 DOI: 10.1021/jm701311r  0.72
2008 Mallari JP, Shelat AA, Obrien T, Caffrey CR, Kosinski A, Connelly M, Harbut M, Greenbaum D, McKerrow JH, Guy RK. Development of potent purine-derived nitrile inhibitors of the trypanosomal protease TbcatB. Journal of Medicinal Chemistry. 51: 545-52. PMID 18173229 DOI: 10.1021/jm070760l  0.72
2008 Stack CM, Caffrey CR, Donnelly SM, Seshaadri A, Lowther J, Tort JF, Collins PR, Robinson MW, Xu W, McKerrow JH, Craik CS, Geiger SR, Marion R, Brinen LS, Dalton JP. Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica. The Journal of Biological Chemistry. 283: 9896-908. PMID 18160404 DOI: 10.1074/jbc.M708521200  0.72
2008 Jaishankar P, Hansell E, Zhao DM, Doyle PS, McKerrow JH, Renslo AR. Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes. Bioorganic & Medicinal Chemistry Letters. 18: 624-8. PMID 18055204 DOI: 10.1016/j.bmcl.2007.11.070  0.72
2008 Dvorák J, Mashiyama ST, Braschi S, Sajid M, Knudsen GM, Hansell E, Lim KC, Hsieh I, Bahgat M, Mackenzie B, Medzihradszky KF, Babbitt PC, Caffrey CR, McKerrow JH. Differential use of protease families for invasion by schistosome cercariae. Biochimie. 90: 345-58. PMID 17936488 DOI: 10.1016/j.biochi.2007.08.013  0.72
2008 Aslam A, Quinn P, McIntosh RS, Shi J, Ghumra A, McKerrow JH, Bunting KA, Dunne DW, Doenhoff MJ, Morrison SL, Zhang K, Pleass RJ. Proteases from Schistosoma mansoni cercariae cleave IgE at solvent exposed interdomain regions. Molecular Immunology. 45: 567-74. PMID 17631966 DOI: 10.1016/j.molimm.2007.05.021  0.72
2007 González FV, Izquierdo J, Rodríguez S, McKerrow JH, Hansell E. Dipeptidyl-alpha,beta-epoxyesters as potent irreversible inhibitors of the cysteine proteases cruzain and rhodesain. Bioorganic & Medicinal Chemistry Letters. 17: 6697-700. PMID 17977725 DOI: 10.1016/j.bmcl.2007.10.056  0.72
2007 Davis FP, Barkan DT, Eswar N, McKerrow JH, Sali A. Host pathogen protein interactions predicted by comparative modeling. Protein Science : a Publication of the Protein Society. 16: 2585-96. PMID 17965183 DOI: 10.1110/ps.073228407  0.72
2007 Kanaji S, Tanaka Y, Sakata Y, Takeshita K, Arima K, Ohta S, Hansell EJ, Caffrey C, Mottram JC, Lowther J, Donnelly S, Stack C, Kadowaki T, Yamamoto K, McKerrow JH, et al. Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases. Febs Letters. 581: 4260-4. PMID 17707374 DOI: 10.1016/j.febslet.2007.07.072  0.72
2007 Doyle PS, Zhou YM, Engel JC, McKerrow JH. A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection. Antimicrobial Agents and Chemotherapy. 51: 3932-9. PMID 17698625 DOI: 10.1128/AAC.00436-07  0.72
2007 Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH. The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. Structure (London, England : 1993). 15: 535-43. PMID 17502099 DOI: 10.1016/j.str.2007.03.012  0.72
2007 Jolly ER, Chin CS, Miller S, Bahgat MM, Lim KC, DeRisi J, McKerrow JH. Gene expression patterns during adaptation of a helminth parasite to different environmental niches. Genome Biology. 8: R65. PMID 17456242 DOI: 10.1186/gb-2007-8-4-r65  0.72
2007 Delcroix M, Medzihradsky K, Caffrey CR, Fetter RD, McKerrow JH. Proteomic analysis of adult S. mansoni gut contents. Molecular and Biochemical Parasitology. 154: 95-7. PMID 17451823 DOI: 10.1016/j.molbiopara.2007.03.008  0.72
2007 Caffrey CR, Steverding D, Swenerton RK, Kelly B, Walshe D, Debnath A, Zhou YM, Doyle PS, Fafarman AT, Zorn JA, Land KM, Beauchene J, Schreiber K, Moll H, Ponte-Sucre A, ... ... McKerrow JH, et al. Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro. Antimicrobial Agents and Chemotherapy. 51: 2164-72. PMID 17371810 DOI: 10.1128/AAC.01418-06  0.72
2007 Debnath A, Tashker JS, Sajid M, McKerrow JH. Transcriptional and secretory responses of Entamoeba histolytica to mucins, epithelial cells and bacteria. International Journal For Parasitology. 37: 897-906. PMID 17362964 DOI: 10.1016/j.ijpara.2007.01.016  0.72
2007 Sojka D, Hajdusek O, Dvorák J, Sajid M, Franta Z, Schneider EL, Craik CS, Vancová M, Buresová V, Bogyo M, Sexton KB, McKerrow JH, Caffrey CR, Kopácek P. IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus. International Journal For Parasitology. 37: 713-24. PMID 17336985 DOI: 10.1016/j.ijpara.2006.12.020  0.72
2007 Abdulla MH, Lim KC, Sajid M, McKerrow JH, Caffrey CR. Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor. Plos Medicine. 4: e14. PMID 17214506 DOI: 10.1371/journal.pmed.0040014  0.72
2007 Hirata KK, Que X, Melendez-Lopez SG, Debnath A, Myers S, Herdman DS, Orozco E, Bhattacharya A, McKerrow JH, Reed SL. A phagocytosis mutant of Entamoeba histolytica is less virulent due to deficient proteinase expression and release. Experimental Parasitology. 115: 192-9. PMID 16987516 DOI: 10.1016/j.exppara.2006.08.004  0.72
2007 Setzer WN, Stokes SL, Penton AF, Takaku S, Haber WA, Hansell E, Caffrey CR, McKerrow JH. Cruzain inhibitory activity of leaf essential oils of neotropical lauraceae and essential oil components Natural Product Communications. 2: 1203-1210.  0.72
2007 Setzer WN, Stokes SL, Bansal A, Haber WA, Caffrey CR, Hanseir E, McKerrow JH. Chemical composition and cruzain inhibitory activity of croton draco bark essential oil from monteverde, costa rica Natural Product Communications. 2: 685-689.  0.72
2007 Agius BR, Vogler B, Stokes SL, Setzer WN, Caffrey CR, Hansell E, McKerrow JH. Inhibition of cruzain by triterpenoids isolated from a Salacia species from Monteverde, Costa Rica Natural Product Communications. 2: 1083-1084.  0.72
2006 McKerrow JH, Caffrey C, Kelly B, Loke P, Sajid M. Proteases in parasitic diseases. Annual Review of Pathology. 1: 497-536. PMID 18039124 DOI: 10.1146/annurev.pathol.1.110304.100151  0.72
2006 Renslo AR, McKerrow JH. Drug discovery and development for neglected parasitic diseases Nature Chemical Biology. 2: 701-710. PMID 17108988 DOI: 10.1038/nchembio837  0.72
2006 Blank RB, Lamb EW, Tocheva AS, Crow ET, Lim KC, McKerrow JH, Davies SJ. The common gamma chain cytokines interleukin (IL)-2 and IL-7 indirectly modulate blood fluke development via effects on CD4+ T cells. The Journal of Infectious Diseases. 194: 1609-16. PMID 17083048 DOI: 10.1086/508896  0.72
2006 Delcroix M, Sajid M, Caffrey CR, Lim KC, Dvorák J, Hsieh I, Bahgat M, Dissous C, McKerrow JH. A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite. The Journal of Biological Chemistry. 281: 39316-29. PMID 17028179 DOI: 10.1074/jbc.M607128200  0.72
2006 Mcintosh RS, Jones FM, Dunne DW, Mckerrow JH, Pleass RJ. Characterization of immunoglobulin binding by schistosomes Parasite Immunology. 28: 407-419. PMID 16916364 DOI: 10.1111/j.1365-3024.2006.00829.x  0.72
2006 Beckham SA, Law RH, Smooker PM, Quinsey NS, Caffrey CR, McKerrow JH, Pike RN, Spithill TW. Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite. Biological Chemistry. 387: 1053-61. PMID 16895475 DOI: 10.1515/BC.2006.130  0.72
2006 Wang SX, Pandey KC, Somoza JR, Sijwali PS, Kortemme T, Brinen LS, Fletterick RJ, Rosenthal PJ, McKerrow JH. Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. Proceedings of the National Academy of Sciences of the United States of America. 103: 11503-8. PMID 16864794 DOI: 10.1073/pnas.0600489103  0.72
2006 MacKey ZB, Baca AM, Mallari JP, Apsel B, Shelat A, Hansell EJ, Chiang PK, Wolff B, Guy KR, Williams J, McKerrow JH. Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei Chemical Biology and Drug Design. 67: 355-363. PMID 16784460 DOI: 10.1111/j.1747-0285.2006.00389.x  0.72
2006 DuBois KN, Abodeely M, Sajid M, Engel JC, McKerrow JH. Giardia lamblia cysteine proteases. Parasitology Research. 99: 313-6. PMID 16598471 DOI: 10.1007/s00436-006-0149-4  0.72
2006 Rapp M, Haubrich TA, Perrault J, Mackey ZB, McKerrow JH, Chiang PK, Wnuk SF. Antitrypanosomal activity of 5'-deoxy-5'-(iodomethylene)adenosine and related 6-N-cyclopropyladenosine analogues. Journal of Medicinal Chemistry. 49: 2096-102. PMID 16539398 DOI: 10.1021/jm0511379  0.72
2006 Vicik R, Hoerr V, Glaser M, Schultheis M, Hansell E, McKerrow JH, Holzgrabe U, Caffrey CR, Ponte-Sucre A, Moll H, Stich A, Schirmeister T. Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents Bioorganic and Medicinal Chemistry Letters. 16: 2753-2757. PMID 16516467 DOI: 10.1016/j.bmcl.2006.02.026  0.72
2005 Barr SC, Warner KL, Kornreic BG, Piscitelli J, Wolfe A, Benet L, McKerrow JH. A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi Antimicrobial Agents and Chemotherapy. 49: 5160-5161. PMID 16304193 DOI: 10.1128/AAC.49.12.5160-5161.2005  0.72
2005 McKerrow JH. Designing drugs for parasitic diseases of the developing world Plos Medicine. 2: 0712-0714. PMID 16120007 DOI: 10.1371/journal.pmed.0020210  0.72
2005 Knudsen GM, Medzihradszky KF, Lim KC, Hansell E, McKerrow JH. Proteomic analysis of Schistosoma mansoni cercarial secretions. Molecular & Cellular Proteomics : McP. 4: 1862-75. PMID 16112986 DOI: 10.1074/mcp.M500097-MCP200  0.72
2005 Pandey KC, Wang SX, Sijwali PS, Lau AL, McKerrow JH, Rosenthal PJ. The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif Proceedings of the National Academy of Sciences of the United States of America. 102: 9138-9143. PMID 15964982 DOI: 10.1073/pnas.0502368102  0.72
2005 Dvořák J, Delcroix M, Rossi A, Vopálenský V, Pospíšek M, Šedinová M, Mikeš L, Sajid M, Sali A, McKerrow JH, Horák P, Caffrey CR. Multiple cathepsin B isoforms in schistosomula of Trichobilharzia regenti: Identification, characterisation and putative role in migration and nutrition International Journal For Parasitology. 35: 895-910. PMID 15950230 DOI: 10.1016/j.ijpara.2005.02.018  0.72
2005 Davies SJ, Smith SJ, Lim KC, Zhang H, Purchio AF, McKerrow JH, West DB. In vivo imaging of tissue eosinophilia and eosinopoietic responses to schistosome worms and eggs. International Journal For Parasitology. 35: 851-9. PMID 15950229 DOI: 10.1016/j.ijpara.2005.02.017  0.72
2005 Caffrey CR, Placha L, Barinka C, Hradilek M, Dostál J, Sajid M, McKerrow JH, Majer P, Konvalinka J, Vondráŝek J. Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors Biological Chemistry. 386: 339-349. PMID 15899696 DOI: 10.1515/BC.2005.041  0.72
2005 Wippersteg V, Sajid M, Walshe D, Khiem D, Salter JP, McKerrow JH, Grevelding CG, Caffrey CR. Biolistic transformation of Schistosoma mansoni with 5' flanking regions of two peptidase genes promotes tissue-specific expression. International Journal For Parasitology. 35: 583-9. PMID 15862572 DOI: 10.1016/j.ijpara.2005.02.002  0.72
2005 Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain. Bioorganic & Medicinal Chemistry Letters. 15: 121-3. PMID 15582423 DOI: 10.1016/j.bmcl.2004.10.023  0.72
2004 Guiliano DB, Hong X, McKerrow JH, Blaxter ML, Oksov Y, Liu J, Ghedin E, Lustigman S. A gene family of cathepsin L-like proteases of filarial nematodes are associated with larval molting and cuticle and eggshell remodeling. Molecular and Biochemical Parasitology. 136: 227-42. PMID 15478801 DOI: 10.1016/j.molbiopara.2004.03.015  0.72
2004 Kaviratne M, Hesse M, Leusink M, Cheever AW, Davies SJ, McKerrow JH, Wakefield LM, Letterio JJ, Wynn TA. IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent. Journal of Immunology (Baltimore, Md. : 1950). 173: 4020-9. PMID 15356151  0.72
2004 Götz MG, Caffrey CR, Hansell E, McKerrow JH, Powers JC. Peptidyl allyl sulfones: A new class of inhibitors for clan CA cysteine proteases Bioorganic and Medicinal Chemistry. 12: 5203-5211. PMID 15351403 DOI: 10.1016/j.bmc.2004.07.016  0.72
2004 Mackey ZB, O'Brien TC, Greenbaum DC, Blank RB, McKerrow JH. A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei. The Journal of Biological Chemistry. 279: 48426-33. PMID 15326171 DOI: 10.1074/jbc.M402470200  0.72
2004 Debnath A, Das P, Sajid M, McKerrow JH. Identification of genomic responses to collagen binding by trophozoites of Entamoeba histolytica Journal of Infectious Diseases. 190: 448-457. PMID 15243916 DOI: 10.1086/422323  0.72
2004 Williamson AL, Lecchi P, Turk BE, Choe Y, Hotez PJ, McKerrow JH, Cantley LC, Sajid M, Craik CS, Loukas A. A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms. The Journal of Biological Chemistry. 279: 35950-7. PMID 15199048 DOI: 10.1074/jbc.M405842200  0.72
2004 Mahmoudzadeh-Niknam H, McKerrow JH. Leishmania tropica: Cysteine proteases are essential for growth and pathogenicity Experimental Parasitology. 106: 158-163. PMID 15172223 DOI: 10.1016/j.exppara.2004.03.005  0.72
2004 Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K. Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi. Journal of Medicinal Chemistry. 47: 3212-9. PMID 15163200 DOI: 10.1021/jm030549j  0.72
2004 Caffrey CR, McKerrow JH, Salter JP, Sajid M. Blood 'n' guts: an update on schistosome digestive peptidases. Trends in Parasitology. 20: 241-8. PMID 15105025 DOI: 10.1016/j.pt.2004.03.004  0.72
2004 Ekici OD, Götz MG, James KE, Li ZZ, Rukamp BJ, Asgian JL, Caffrey CR, Hansell E, Dvorák J, McKerrow JH, Potempa J, Travis J, Mikolajczyk J, Salvesen GS, Powers JC. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. Journal of Medicinal Chemistry. 47: 1889-92. PMID 15055989 DOI: 10.1021/jm049938j  0.72
2004 Hernandez DC, Lim KC, McKerrow JH, Davies SJ. Schistosoma mansoni: sex-specific modulation of parasite growth by host immune signals. Experimental Parasitology. 106: 59-61. PMID 15013791 DOI: 10.1016/j.exppara.2004.01.003  0.72
2004 Davies SJ, Lim KC, Blank RB, Kim JH, Lucas KD, Hernandez DC, Sedgwick JD, McKerrow JH. Involvement of TNF in limiting liver pathology and promoting parasite survival during schistosome infection. International Journal For Parasitology. 34: 27-36. PMID 14711587 DOI: 10.1016/j.ijpara.2003.10.010  0.72
2003 James KE, Götz MG, Caffrey CR, Hansell E, Carter W, Barrett AJ, McKerrow JH, Powers JC. Aza-peptide epoxides: potent and selective inhibitors of Schistosoma mansoni and pig kidney legumains (asparaginyl endopeptidases). Biological Chemistry. 384: 1613-8. PMID 14719804 DOI: 10.1515/BC.2003.179  0.72
2003 Bok RA, Hansell EJ, Nguyen TP, Greenberg NM, McKerrow JH, Shuman MA. Patterns of protease production during prostate cancer progression: Proteomic evidence for cascades in a transgenic model Prostate Cancer and Prostatic Diseases. 6: 272-280. PMID 14663466 DOI: 10.1038/sj.pcan.4500676  0.72
2003 Chiyanzu I, Hansell E, Gut J, Rosenthal PJ, McKerrow JH, Chibale K. Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain Bioorganic and Medicinal Chemistry Letters. 13: 3527-3530. PMID 14505663 DOI: 10.1016/S0960-894X(03)00756-X  0.72
2003 Davies SJ, McKerrow JH. Developmental plasticity in schistosomes and other helminths. International Journal For Parasitology. 33: 1277-84. PMID 13678642 DOI: 10.1016/S0020-7519(03)00161-9  0.72
2003 Sajid M, McKerrow JH, Hansell E, Mathieu MA, Lucas KD, Hsieh I, Greenbaum D, Bogyo M, Salter JP, Lim KC, Franklin C, Kim JH, Caffrey CR. Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase. Molecular and Biochemical Parasitology. 131: 65-75. PMID 12967713 DOI: 10.1016/S0166-6851(03)00194-4  0.72
2003 Nkemngu NJ, Grande R, Hansell E, McKerrow JH, Caffrey CR, Steverding D. Improved trypanocidal activities of cathepsin L inhibitors International Journal of Antimicrobial Agents. 22: 155-159. PMID 12927956 DOI: 10.1016/S0924-8579(03)00096-7  0.72
2003 Que X, Kim SH, Sajid M, Eckmann L, Dinarello CA, McKerrow JH, Reed SL. A surface amebic cysteine proteinase inactivates interleukin-18. Infection and Immunity. 71: 1274-80. PMID 12595442 DOI: 10.1128/IAI.71.3.1274-1280.2003  0.72
2002 Du X, Guo C, Hansell E, Doyle PS, Caffrey CR, Holler TP, McKerrow JH, Cohen FE. Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain. Journal of Medicinal Chemistry. 45: 2695-707. PMID 12061873 DOI: 10.1021/jm010459j  0.72
2002 Rodrigues CR, Flaherty TM, Springer C, McKerrow JH, Cohen FE. CoMFA and HQSAR of acylhydrazide cruzain inhibitors. Bioorganic & Medicinal Chemistry Letters. 12: 1537-41. PMID 12031337 DOI: 10.1016/S0960-894X(02)00189-0  0.72
2002 Salter JP, Choe Y, Albrecht H, Franklin C, Lim KC, Craik CS, McKerrow JH. Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes. The Journal of Biological Chemistry. 277: 24618-24. PMID 11986325 DOI: 10.1074/jbc.M202364200  0.72
2002 Mathieu MA, Bogyo M, Caffrey CR, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH. Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries Molecular and Biochemical Parasitology. 121: 99-105. PMID 11985866 DOI: 10.1016/S0166-6851(02)00026-9  0.72
2002 Caffrey CR, Salter JP, Lucas KD, Khiem D, Hsieh I, Lim KC, Ruppel A, McKerrow JH, Sajid M. SmCB2, a novel tegumental cathepsin B from adult Schistosoma mansoni. Molecular and Biochemical Parasitology. 121: 49-61. PMID 11985862 DOI: 10.1016/S0166-6851(02)00022-1  0.72
2002 Caffrey CR, Schanz M, Nkemngu NJ, Nkemgu-Njinkeng J, Brush M, Hansell E, Cohen FE, Flaherty TM, McKerrow JH, Steverding D. Screening of acyl hydrazide proteinase inhibitors for antiparasitic activity against Trypanosoma brucei. International Journal of Antimicrobial Agents. 19: 227-31. PMID 11932146 DOI: 10.1016/S0924-8579(01)00488-5  0.72
2002 Sajid M, McKerrow JH. Cysteine proteases of parasitic organisms Molecular and Biochemical Parasitology. 120: 1-21. PMID 11849701  0.72
2002 Que X, Brinen LS, Perkins P, Herdman S, Hirata K, Torian BE, Rubin H, McKerrow JH, Reed SL. Cysteine proteinases from distinct cellular compartments are recruited to phagocytic vesicles by Entamoeba histolytica. Molecular and Biochemical Parasitology. 119: 23-32. PMID 11755183 DOI: 10.1016/S0166-6851(01)00387-5  0.72
2002 Cichewicz RH, Lim KC, McKerrow JH, Nair MG. Kwanzoquinones A-G and other constituents of Hemerocallis fulva 'Kwanzo' roots and their activity against the human pathogenic trematode Schistosoma mansoni Tetrahedron. 58: 8597-8606. DOI: 10.1016/S0040-4020(02)00802-5  0.72
2002 Guo C, Du XH, McKerrow JH, Cohen FE. Synthesis of N1-substituted-3-aryl-4-alkyl-4, 5-dihydro-1H-1- pyrazolethiocarboxamide as novel small molecule inhibitors of cysteine protease of T. cruzi Chinese Chemical Letters. 13: 1043-1046.  0.72
2001 Caffrey CR, Hansell E, Lucas KD, Brinen LS, Alvarez Hernandez A, Cheng J, Gwaltney SL, Roush WR, Stierhof YD, Bogyo M, Steverding D, McKerrow JH. Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense. Molecular and Biochemical Parasitology. 118: 61-73. PMID 11704274 DOI: 10.1016/S0166-6851(01)00368-1  0.72
2001 Davies SJ, Grogan JL, Blank RB, Lim KC, Locksley RM, McKerrow JH. Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes. Science (New York, N.Y.). 294: 1358-61. PMID 11701932 DOI: 10.1126/science.1064462  0.72
2001 Lecaille F, Cotton J, McKerrow JH, Ferrer-Di Martino M, Boll-Bataillé E, Gauthier F, Lalmanach G. Reversible inhibition of cathepsin L-like proteases by 4-mer pseudopeptides. Febs Letters. 507: 362-6. PMID 11696372 DOI: 10.1016/S0014-5793(01)03008-3  0.72
2001 Roush WR, Cheng J, Knapp-Reed B, Alvarez-Hernandez A, McKerrow JH, Hansell E, Engel JC. Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain. Bioorganic & Medicinal Chemistry Letters. 11: 2759-62. PMID 11591518 DOI: 10.1016/S0960-894X(01)00566-2  0.72
2001 Paddock CD, McKerrow JH, Hansell E, Foreman KW, Hsieh I, Marshall N. Identification, cloning, and recombinant expression of procalin, a major triatomine allergen Journal of Immunology. 167: 2694-2699. PMID 11509613  0.72
2000 Brinen LS, Que X, McKerrow JH, Reed SL. Homology modeling of Entamoeba histolytica cysteine proteinases reveals the basis for cathepsin L-like structure with cathepsin B-like specificity. Archives of Medical Research. 31: S63-4. PMID 11070225 DOI: 10.1016/S0188-4409(00)00154-5  0.72
2000 Troeberg L, Chen X, Flaherty TM, Morty RE, Cheng M, Hua H, Springer C, McKerrow JH, Kenyon GL, Lonsdale-Eccles JD, Coetzer TH, Cohen FE. Chalcone, acyl hydrazide, and related amides kill cultured Trypanosoma brucei brucei. Molecular Medicine (Cambridge, Mass.). 6: 660-9. PMID 11055585  0.72
2000 Brinen LS, Hansell E, Cheng J, Roush WR, McKerrow JH, Fletterick RJ. A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure (London, England : 1993). 8: 831-40. PMID 10997902 DOI: 10.1016/S0969-2126(00)00173-8  0.72
2000 Salter JP, Lim KC, Hansell E, Hsieh I, McKerrow JH. Schistosome invasion of human skin and degradation of dermal elastin are mediated by a single serine protease. The Journal of Biological Chemistry. 275: 38667-73. PMID 10993899 DOI: 10.1074/jbc.M006997200  0.72
2000 Du X, Hansell E, Engel JC, Caffrey CR, Cohen FE, McKerrow JH. Aryl ureas represent a new class of anti-trypanosomal agents. Chemistry & Biology. 7: 733-42. PMID 10980453 DOI: 10.1016/S1074-5521(00)00018-1  0.72
2000 McKerrow JH, Bhargava V, Hansell E, Huling S, Kuwahara T, Matley M, Coussens L, Warren R. A functional proteomics screen of proteases in colorectal carcinoma Molecular Medicine (Cambridge, Mass.). 6: 450-460. PMID 10952024  0.72
2000 Engel JC, García CT, Hsieh I, Doyle PS, McKerrow JH. Upregulation of the secretory pathway in cysteine protease inhibitor-resistant Trypanosoma cruzi Journal of Cell Science. 113: 1345-1354. PMID 10725218  0.72
2000 Stoka V, Turk B, McKerrow JH, Björk I, Cazzulo JJ, Turk V. The high stability of cruzipain against pH-induced inactivation is not dependent on its C-terminal domain Febs Letters. 469: 29-32. PMID 10708750 DOI: 10.1016/S0014-5793(00)01221-7  0.72
2000 Caffrey CR, Mathieu MA, Gaffney AM, Salter JP, Sajid M, Lucas KD, Franklin C, Bogyo M, McKerrow JH. Identification of a cDNA encoding an active asparaginyl endopeptidase of Schistosoma mansoni and its expression in Pichia pastoris. Febs Letters. 466: 244-8. PMID 10682836 DOI: 10.1016/S0014-5793(99)01798-6  0.72
2000 Roush WR, Hernandez AA, McKerrow JH, Selzer PM, Hansell E, Engel JC. Design, synthesis and evaluation of D-Homophenylalanyl epoxysuccinate inhibitors of the trypanosomal cysteine protease cruzain Tetrahedron. 56: 9747-9762.  0.72
1999 Engel JC, Doyle PS, McKerrow JH. Trypanocidal effect of cysteine protease inhibitors in vitro and in vivo in experimental chagas disease | Efecto antiparasitario de inhibidores de cistein proteasas in vitro e in vivo en la enfermedad de chagas experimental Medicina. 59: 171-175. PMID 10668260  0.72
1999 Britton C, Redmond DL, Knox DP, McKerrow JH, Barry JD. Identification of promoter elements of parasite nematode genes in transgenic Caenorhabditis elegans. Molecular and Biochemical Parasitology. 103: 171-81. PMID 10551361 DOI: 10.1016/S0166-6851(99)00121-8  0.72
1999 Selzer PM, Pingel S, Hsieh I, Ugele B, Chan VJ, Engel JC, Bogyo M, Russell DG, Sakanari JA, Mckerrow JH. Cysteine protease inhibitors as chemotherapy: Lessons from a parasite target Proceedings of the National Academy of Sciences of the United States of America. 96: 11015-11022. PMID 10500116 DOI: 10.1073/pnas.96.20.11015  0.72
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