| Year |
Citation |
Score |
| 2024 |
Mahoney MW, Helander J, Kooner AS, Norman M, Damalanka VC, De Bona P, Kasperkiewicz P, Rut W, Poreba M, Kashipathy MM, Battaile KP, Lovell S, O'Donoghue AJ, Craik CS, Drag M, et al. Use of protease substrate specificity screening in the rational design of selective protease inhibitors with unnatural amino acids: Application to HGFA, matriptase, and hepsin. Protein Science : a Publication of the Protein Society. 33: e5110. PMID 39073183 DOI: 10.1002/pro.5110 |
0.308 |
|
| 2020 |
Boyce JH, Dang B, Ary B, Edmondson Q, Craik CS, DeGrado WF, Seiple IB. Platform to Discover Protease-Activated Antibiotics and Application to Siderophore-Antibiotic Conjugates. Journal of the American Chemical Society. PMID 33301681 DOI: 10.1021/jacs.0c06987 |
0.766 |
|
| 2020 |
Sevillano N, Bohn MF, Zimanyi M, Chen Y, Petzold C, Gupta S, Ralston CY, Craik CS. Structure of an affinity-matured inhibitory recombinant fab against urokinase plasminogen activator reveals basis of potency and specificity. Biochimica Et Biophysica Acta. Proteins and Proteomics. 140562. PMID 33221341 DOI: 10.1016/j.bbapap.2020.140562 |
0.313 |
|
| 2020 |
Lohse MB, Brenes LR, Ziv N, Winter MB, Craik CS, Johnson AD. An Opaque Cell-Specific Expression Program of Secreted Proteases and Transporters Allows Cell-Type Cooperation in . Genetics. PMID 32839241 DOI: 10.1534/Genetics.120.303613 |
0.309 |
|
| 2020 |
Cogan DP, Li X, Sevillano N, Mathews II, Matsui T, Craik CS, Khosla C. Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction. Journal of the American Chemical Society. 142: 14933-14939. PMID 32786753 DOI: 10.1021/Jacs.0C05133 |
0.356 |
|
| 2020 |
Lohse MB, Gulati M, Craik CS, Johnson AD, Nobile CJ. Combination of Antifungal Drugs and Protease Inhibitors Prevent Biofilm Formation and Disrupt Mature Biofilms. Frontiers in Microbiology. 11: 1027. PMID 32523574 DOI: 10.3389/Fmicb.2020.01027 |
0.307 |
|
| 2020 |
Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, ... ... Craik CS, et al. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. PMID 32353859 DOI: 10.1038/S41586-020-2286-9 |
0.307 |
|
| 2020 |
Vasiljeva O, Menendez E, Nguyen M, Craik CS, Michael Kavanaugh W. Monitoring protease activity in biological tissues using antibody prodrugs as sensing probes. Scientific Reports. 10: 5894. PMID 32246002 DOI: 10.1038/S41598-020-62339-7 |
0.377 |
|
| 2020 |
Dvořáková H, Leontovyč R, Macháček T, O'Donoghue AJ, Šedo O, Zdráhal Z, Craik CS, Caffrey CR, Horák P, Mikeš L. Isoforms of Cathepsin B1 in Neurotropic Schistosomula of Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystatin. Frontiers in Cellular and Infection Microbiology. 10: 66. PMID 32175287 DOI: 10.3389/Fcimb.2020.00066 |
0.468 |
|
| 2019 |
Ravalin M, Basu K, Gestwicki JE, Craik CS. End-binding E3 ubiquitin ligases enable protease signaling. Acs Chemical Biology. PMID 31714737 DOI: 10.1021/Acschembio.9B00621 |
0.344 |
|
| 2019 |
Ravalin M, Theofilas P, Basu K, Opoku-Nsiah KA, Assimon VA, Medina-Cleghorn D, Chen YF, Bohn MF, Arkin M, Grinberg LT, Craik CS, Gestwicki JE. Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases. Nature Chemical Biology. 15: 786-794. PMID 31320752 DOI: 10.1038/S41589-019-0322-6 |
0.304 |
|
| 2019 |
Basu K, Green EM, Cheng Y, Craik CS. Why recombinant antibodies - benefits and applications. Current Opinion in Biotechnology. 60: 153-158. PMID 30849700 DOI: 10.1016/J.Copbio.2019.01.012 |
0.32 |
|
| 2019 |
Butler VJ, Cortopassi WA, Argouarch AR, Ivry SL, Craik CS, Jacobson MP, Kao AW. Progranulin Stimulates the in vitro Maturation of pro-Cathepsin D at Acidic pH. Journal of Molecular Biology. PMID 30690031 DOI: 10.1016/J.Jmb.2019.01.027 |
0.348 |
|
| 2018 |
Damalanka VC, Han Z, Karmakar P, O'Donoghue AJ, La Greca F, Kim T, Pant S, Helander J, Klefström J, Craik CS, Janetka JW. Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology. Journal of Medicinal Chemistry. PMID 30571119 DOI: 10.1021/Acs.Jmedchem.8B01536 |
0.382 |
|
| 2018 |
Schneidman-Duhovny D, Khuri N, Dong GQ, Winter MB, Shifrut E, Friedman N, Craik CS, Pratt KP, Paz P, Aswad F, Sali A. Predicting CD4 T-cell epitopes based on antigen cleavage, MHCII presentation, and TCR recognition. Plos One. 13: e0206654. PMID 30399156 DOI: 10.1371/Journal.Pone.0206654 |
0.304 |
|
| 2018 |
Li X, Sevillano N, La Greca F, Hsu J, Mathews II, Matsui T, Craik CS, Khosla C. Discovery and characterization of a thioesterase-specific monoclonal antibody that recognizes the 6-deoxyerythronolide B synthase. Biochemistry. PMID 30289692 DOI: 10.1021/Acs.Biochem.8B00886 |
0.361 |
|
| 2018 |
Debela M, Magdolen V, Skala W, Elsässer B, Schneider EL, Craik CS, Biniossek ML, Schilling O, Bode W, Brandstetter H, Goettig P. Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin. Scientific Reports. 8: 10705. PMID 30013126 DOI: 10.1038/S41598-018-29058-6 |
0.408 |
|
| 2018 |
Li X, Sevillano N, La Greca F, Deis L, Liu YC, Deller MC, Mathews II, Matsui T, Cane DE, Craik CS, Khosla C. Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module. Journal of the American Chemical Society. PMID 29762030 DOI: 10.1021/Jacs.8B02100 |
0.317 |
|
| 2018 |
Corvo I, Ferraro F, Merlino A, Zuberbühler K, O'Donoghue AJ, Pastro L, Pi-Denis N, Basika T, Roche L, McKerrow JH, Craik CS, Caffrey CR, Tort JF. Substrate Specificity of Cysteine Proteases Beyond the S Pocket: Mutagenesis and Molecular Dynamics Investigation of Cathepsins L. Frontiers in Molecular Biosciences. 5: 40. PMID 29725596 DOI: 10.3389/Fmolb.2018.00040 |
0.448 |
|
| 2018 |
Leontovyč A, Ulrychová L, O'Donoghue AJ, Vondrášek J, Marešová L, Hubálek M, Fajtová P, Chanová M, Jiang Z, Craik CS, Caffrey CR, Mareš M, Dvořák J, Horn M. SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties. Plos Neglected Tropical Diseases. 12: e0006446. PMID 29677188 DOI: 10.1371/Journal.Pntd.0006446 |
0.327 |
|
| 2018 |
Binning JM, Smith AM, Hultquist JF, Craik CS, Caretta N, Campbell MG, Burton L, La Greca F, McGregor MJ, Ta HM, Bartholomeeusen K, Peterlin BM, Krogan NJ, Sevillano N, Cheng Y, et al. Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors. Plos Pathogens. 14: e1006830. PMID 29304101 DOI: 10.1371/Journal.Ppat.1006830 |
0.304 |
|
| 2017 |
Winter MB, La Greca F, Arastu-Kapur S, Caiazza F, Cimermancic P, Buchholz TJ, Anderl JL, Ravalin M, Bohn MF, Sali A, O'Donoghue AJ, Craik CS. Immunoproteasome functions explained by divergence in cleavage specificity and regulation. Elife. 6. PMID 29182146 DOI: 10.7554/Elife.27364 |
0.355 |
|
| 2017 |
Ivry SL, Meyer NO, Winter MB, Bohn MF, Knudsen GM, O'Donoghue AJ, Craik CS. Global substrate specificity profiling of post-translational modifying enzymes. Protein Science : a Publication of the Protein Society. PMID 29168252 DOI: 10.1002/Pro.3352 |
0.408 |
|
| 2017 |
Stefan Isaac R, Sanulli S, Tibble R, Hornsby M, Ravalin M, Craik CS, Gross JD, Narlikar GJ. Biochemical basis for distinct roles of the heterochromatin proteins Swi6 and Chp2. Journal of Molecular Biology. PMID 28942089 DOI: 10.1016/J.Jmb.2017.09.012 |
0.345 |
|
| 2017 |
Acker TM, Gable JE, Bohn MF, Jaishankar P, Thompson MC, Fraser JS, Renslo AR, Craik CS. Allosteric Inhibitors, Crystallography and Comparative Analysis Reveal Network of Coordinated Movement Across Human Herpesvirus Proteases. Journal of the American Chemical Society. PMID 28759216 DOI: 10.1021/Jacs.7B04030 |
0.409 |
|
| 2017 |
Kara E, Manna D, Løset GÅ, Schneider EL, Craik CS, Kanse S. Analysis of the substrate specificity of Factor VII activating protease (FSAP) and design of specific and sensitive peptide substrates. Thrombosis and Haemostasis. 117. PMID 28726978 DOI: 10.1160/Th17-02-0081 |
0.459 |
|
| 2017 |
Wilkinson DJ, Habgood A, Lamb HK, Thompson P, Hawkins AR, Désilets A, Leduc R, Steinmetzer T, Hammami M, Lee MS, Craik CS, Watson S, Lin H, Milner JM, Rowan AD. Matriptase induces metalloproteinase-dependent aggrecanolysis in vitro and in vivo: multiple mechanisms promote cartilage damage in osteoarthritis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 28464560 DOI: 10.1002/Art.40133 |
0.301 |
|
| 2017 |
Lourenço AL, Salvador RRS, Silva LA, Saito MS, Mello JFR, Cabral LM, Rodrigues CR, Vera MAF, Muri EMF, de Souza AMT, Craik CS, Dias LRS, Castro HC, Sathler PC. Synthesis and mechanistic evaluation of novel N'-benzylidene-carbohydrazide-1H-pyrazolo[3,4-b]pyridine derivatives as non-anionic antiplatelet agents. European Journal of Medicinal Chemistry. 135: 213-229. PMID 28453995 DOI: 10.1016/J.Ejmech.2017.04.023 |
0.301 |
|
| 2017 |
Ivry SL, Sharib JM, Dominguez DA, Roy N, Hatcher SE, Yip-Schneider M, Schmidt CM, Brand RE, Park WG, Hebrok M, Kim G, O'Donoghue AJ, Kirkwood KS, Craik CS. Global protease activity profiling provides differential diagnosis of pancreatic cysts. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28424202 DOI: 10.1158/1078-0432.Ccr-16-2987 |
0.318 |
|
| 2017 |
Roncase EJ, Moon C, Chatterjee S, González-Páez GE, Craik CS, O'Donoghue AJ, Wolan DW. Substrate Profiling and High Resolution Co-complex Crystal Structure of a Secreted C11 Protease Conserved Across Commensal Bacteria. Acs Chemical Biology. PMID 28414448 DOI: 10.1021/Acschembio.7B00143 |
0.443 |
|
| 2017 |
Meyer NO, O'Donoghue AJ, Schulze-Gahmen U, Ravalin M, Moss SM, Winter MB, Knudsen GM, Craik CS. Multiplex Substrate Profiling by Mass Spectrometry for Kinases Reveals Quantitative Substrate Motifs. Analytical Chemistry. PMID 28322550 DOI: 10.1021/Acs.Analchem.6B05002 |
0.365 |
|
| 2017 |
Guo CJ, Chang FY, Wyche TP, Backus KM, Acker TM, Funabashi M, Taketani M, Donia MS, Nayfach S, Pollard KS, Craik CS, Cravatt BF, Clardy J, Voigt CA, Fischbach MA. Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases. Cell. PMID 28111075 DOI: 10.1016/J.Cell.2016.12.021 |
0.311 |
|
| 2016 |
Clarke SC, Dumesic PA, Homer CM, O'Donoghue AJ, La Greca F, Pallova L, Majer P, Madhani HD, Craik CS. Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence. Plos Pathogens. 12: e1006051. PMID 27977806 DOI: 10.1371/Journal.Ppat.1006051 |
0.437 |
|
| 2016 |
Barkan DT, Cheng XL, Celino H, Tran TT, Bhandari A, Craik CS, Sali A, Smythe ML. Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23. Bmc Bioinformatics. 17: 481. PMID 27881076 DOI: 10.1186/S12859-016-1350-9 |
0.321 |
|
| 2016 |
Lentz CS, Ordonez AA, Kasperkiewicz P, La Greca F, O'Donoghue AJ, Schulze CJ, Powers JC, Craik CS, Drag M, Jain SK, Bogyo M. Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 27739665 DOI: 10.1021/Acsinfecdis.6B00092 |
0.392 |
|
| 2016 |
Winter MB, Salcedo EC, Lohse MB, Hartooni N, Gulati M, Sanchez H, Takagi J, Hube B, Andes DR, Johnson AD, Craik CS, Nobile CJ. Global Identification of Biofilm-Specific Proteolysis in Candida albicans. Mbio. 7. PMID 27624133 DOI: 10.1128/Mbio.01514-16 |
0.306 |
|
| 2016 |
Goupil LS, Ivry SL, Hsieh I, Suzuki BM, Craik CS, O'Donoghue AJ, McKerrow JH. Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria. Plos Neglected Tropical Diseases. 10: e0004893. PMID 27501047 DOI: 10.1371/Journal.Pntd.0004893 |
0.425 |
|
| 2016 |
Homer CM, Summers DK, Goranov AI, Clarke SC, Wiesner DL, Diedrich JK, Moresco JJ, Toffaletti D, Upadhya R, Caradonna I, Petnic S, Pessino V, Cuomo CA, Lodge JK, Perfect J, ... ... Craik CS, et al. Intracellular Action of a Secreted Peptide Required for Fungal Virulence. Cell Host & Microbe. PMID 27212659 DOI: 10.1016/J.Chom.2016.05.001 |
0.323 |
|
| 2016 |
Le Gall SM, Szabo R, Lee M, Kirchhofer D, Craik CS, Bugge TH, Camerer E. Matriptase activation connects tissue factor-dependent coagulation initiation to epithelial proteolysis and signaling. Blood. PMID 27114461 DOI: 10.1182/Blood-2015-11-683110 |
0.341 |
|
| 2016 |
Drake CR, Sevillano N, Truillet C, Craik CS, VanBrocklin HF, Evans MJ. Site-Specific Radiofluorination of Biomolecules with 8-[(18)F]-Fluorooctanoic Acid Catalyzed by Lipoic Acid Ligase. Acs Chemical Biology. PMID 27008570 DOI: 10.1021/Acschembio.6B00172 |
0.306 |
|
| 2016 |
Julien O, Zhuang M, Wiita AP, O'Donoghue AJ, Knudsen GM, Craik CS, Wells JA. Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles. Proceedings of the National Academy of Sciences of the United States of America. PMID 27006500 DOI: 10.1073/Pnas.1524900113 |
0.406 |
|
| 2016 |
Li H, O'Donoghue AJ, van der Linden WA, Xie SC, Yoo E, Foe IT, Tilley L, Craik CS, da Fonseca PC, Bogyo M. Structure- and function-based design of Plasmodium-selective proteasome inhibitors. Nature. 530: 233-6. PMID 26863983 DOI: 10.1038/Nature16936 |
0.371 |
|
| 2016 |
Gable JE, Lee GM, Acker TM, Hulce KR, Gonzalez ER, Schweigler P, Melkko S, Farady CJ, Craik CS. Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric Protease. Chemmedchem. PMID 26822284 DOI: 10.1002/Cmdc.201500526 |
0.389 |
|
| 2015 |
Bibo-Verdugo B, O'Donoghue AJ, Rojo-Arreola L, Craik CS, García-Carreño F. Complementary Proteomic and Biochemical Analysis of Peptidases in Lobster Gastric Juice Uncovers the Functional Role of Individual Enzymes in Food Digestion. Marine Biotechnology (New York, N.Y.). PMID 26613762 DOI: 10.1007/S10126-015-9681-5 |
0.398 |
|
| 2015 |
Jones SK, Clarke SC, Craik CS, Bennett RJ. Evolutionary Selection on Barrier Activity: Bar1 Is an Aspartyl Protease with Novel Substrate Specificity. Mbio. 6. PMID 26604258 DOI: 10.1128/Mbio.01604-15 |
0.407 |
|
| 2015 |
Wong KR, Menendez E, Craik CS, Kavanaugh WM, Vasiljeva O. In vivo imaging of protease activity by Probody therapeutic activation. Biochimie. PMID 26546838 DOI: 10.1016/J.Biochi.2015.11.003 |
0.356 |
|
| 2015 |
Dvořák J, Fajtová P, Ulrychová L, Leontovyč A, Rojo-Arreola L, Suzuki BM, Horn M, Mareš M, Craik CS, Caffrey CR, O'Donoghue AJ. Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles. Biochimie. PMID 26409899 DOI: 10.1016/J.Biochi.2015.09.025 |
0.302 |
|
| 2015 |
O'Donoghue AJ, Knudsen GM, Beekman C, Perry JA, Johnson AD, DeRisi JL, Craik CS, Bennett RJ. Destructin-1 is a collagen-degrading endopeptidase secreted by Pseudogymnoascus destructans, the causative agent of white-nose syndrome. Proceedings of the National Academy of Sciences of the United States of America. 112: 7478-83. PMID 25944934 DOI: 10.1073/Pnas.1507082112 |
0.383 |
|
| 2015 |
Wermelinger LS, Frattani FS, Carneiro-Lobo TC, Craik CS, Castro HC, Zingali RB. Ecotin: Exploring a feasible antithrombotic profile. International Journal of Biological Macromolecules. 78: 296-303. PMID 25881959 DOI: 10.1016/J.Ijbiomac.2015.03.071 |
0.319 |
|
| 2015 |
Kim JM, Wu S, Tomasiak TM, Mergel C, Winter MB, Stiller SB, Robles-Colmanares Y, Stroud RM, Tampé R, Craik CS, Cheng Y. Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter Nature. 517: 396-400. PMID 25363761 DOI: 10.1038/Nature13872 |
0.322 |
|
| 2015 |
Sharma V, Panwar P, O'Donoghue AJ, Cui H, Guido RV, Craik CS, Brömme D. Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor. The Biochemical Journal. 465: 163-73. PMID 25279554 DOI: 10.1042/Bj20140809 |
0.431 |
|
| 2014 |
Skala W, Utzschneider DT, Magdolen V, Debela M, Guo S, Craik CS, Brandstetter H, Goettig P. Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity. The Journal of Biological Chemistry. 289: 34267-83. PMID 25326387 DOI: 10.1074/Jbc.M114.598201 |
0.415 |
|
| 2014 |
Gable JE, Lee GM, Jaishankar P, Hearn BR, Waddling CA, Renslo AR, Craik CS. Broad-spectrum allosteric inhibition of herpesvirus proteases. Biochemistry. 53: 4648-60. PMID 24977643 DOI: 10.1021/Bi5003234 |
0.372 |
|
| 2014 |
Grove LM, Southern BD, Jin TH, White KE, Paruchuri S, Harel E, Wei Y, Rahaman SO, Gladson CL, Ding Q, Craik CS, Chapman HA, Olman MA. Urokinase-type plasminogen activator receptor (uPAR) ligation induces a raft-localized integrin signaling switch that mediates the hypermotile phenotype of fibrotic fibroblasts. The Journal of Biological Chemistry. 289: 12791-804. PMID 24644284 DOI: 10.1074/Jbc.M113.498576 |
0.325 |
|
| 2014 |
Dominguez DA, O'Donoghue AJ, Kirkwood KS, Craik CS. Abstract 2506: Differentiating pancreatic cystic neoplasms by global protease specificity Cancer Research. 74: 2506-2506. DOI: 10.1158/1538-7445.Am2014-2506 |
0.345 |
|
| 2013 |
Du X, Chen NL, Wong A, Craik CS, Brömme D. Elastin degradation by cathepsin V requires two exosites. The Journal of Biological Chemistry. 288: 34871-81. PMID 24121514 DOI: 10.1074/Jbc.M113.510008 |
0.37 |
|
| 2013 |
O'Donoghue AJ, Jin Y, Knudsen GM, Perera NC, Jenne DE, Murphy JE, Craik CS, Hermiston TW. Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase. Plos One. 8: e75141. PMID 24073241 DOI: 10.1371/Journal.Pone.0075141 |
0.446 |
|
| 2013 |
Corvo I, O'Donoghue AJ, Pastro L, Pi-Denis N, Eroy-Reveles A, Roche L, McKerrow JH, Dalton JP, Craik CS, Caffrey CR, Tort JF. Dissecting the Active Site of the Collagenolytic Cathepsin L3 Protease of the Invasive Stage of Fasciola hepatica Plos Neglected Tropical Diseases. 7. PMID 23875031 DOI: 10.1371/Journal.Pntd.0002269 |
0.445 |
|
| 2013 |
Small JL, O'Donoghue AJ, Boritsch EC, Tsodikov OV, Knudsen GM, Vandal O, Craik CS, Ehrt S. Substrate specificity of MarP, a periplasmic protease required for resistance to acid and oxidative stress in Mycobacterium tuberculosis. The Journal of Biological Chemistry. 288: 12489-99. PMID 23504313 DOI: 10.1074/Jbc.M113.456541 |
0.445 |
|
| 2013 |
Raman K, Trivedi NN, Raymond WW, Ganesan R, Kirchhofer D, Verghese GM, Craik CS, Schneider EL, Nimishakavi S, Caughey GH. Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors. The Journal of Biological Chemistry. 288: 10588-98. PMID 23447538 DOI: 10.1074/Jbc.M112.449033 |
0.38 |
|
| 2013 |
LeBeau AM, Lee M, Murphy ST, Hann BC, Warren RS, Delos Santos R, Kurhanewicz J, Hanash SM, VanBrocklin HF, Craik CS. Imaging a functional tumorigenic biomarker in the transformed epithelium. Proceedings of the National Academy of Sciences of the United States of America. 110: 93-8. PMID 23248318 DOI: 10.1073/Pnas.1218694110 |
0.346 |
|
| 2012 |
Lee GM, Balouch E, Goetz DH, Lazic A, McKerrow JH, Craik CS. Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy. Biochemistry. 51: 10087-98. PMID 23181936 DOI: 10.1021/Bi301305K |
0.373 |
|
| 2012 |
O'Donoghue AJ, Eroy-Reveles AA, Knudsen GM, Ingram J, Zhou M, Statnekov JB, Greninger AL, Hostetter DR, Qu G, Maltby DA, Anderson MO, Derisi JL, McKerrow JH, Burlingame AL, Craik CS. Global identification of peptidase specificity by multiplex substrate profiling. Nature Methods. 9: 1095-100. PMID 23023596 DOI: 10.1038/Nmeth.2182 |
0.432 |
|
| 2012 |
Craik CS, Shahian T. A screening strategy for trapping the inactive conformer of a dimeric enzyme with a small molecule inhibitor. Methods in Molecular Biology (Clifton, N.J.). 928: 119-31. PMID 22956137 DOI: 10.1007/978-1-62703-008-3_9 |
0.406 |
|
| 2012 |
Nimishakavi S, Besprozvannaya M, Raymond WW, Craik CS, Gruenert DC, Caughey GH. Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 303: L97-106. PMID 22582115 DOI: 10.1152/Ajplung.00303.2011 |
0.344 |
|
| 2012 |
Sojka D, Franta Z, Frantová H, Bartosová P, Horn M, Váchová J, O'Donoghue AJ, Eroy-Reveles AA, Craik CS, Knudsen GM, Caffrey CR, McKerrow JH, Mares M, Kopácek P. Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1). The Journal of Biological Chemistry. 287: 21152-63. PMID 22539347 DOI: 10.1074/Jbc.M112.347922 |
0.411 |
|
| 2012 |
Ingram JR, Rafi SB, Eroy-Reveles AA, Ray M, Lambeth L, Hsieh I, Ruelas D, Lim KC, Sakanari J, Craik CS, Jacobson MP, McKerrow JH. Investigation of the proteolytic functions of an expanded cercarial elastase gene family in Schistosoma mansoni. Plos Neglected Tropical Diseases. 6: e1589. PMID 22509414 DOI: 10.1371/Journal.Pntd.0001589 |
0.363 |
|
| 2012 |
Wu S, Avila-Sakar A, Kim J, Booth DS, Greenberg CH, Rossi A, Liao M, Li X, Alian A, Griner SL, Juge N, Yu Y, Mergel CM, Chaparro-Riggers J, Strop P, ... ... Craik CS, et al. Fabs enable single particle cryoEM studies of small proteins. Structure (London, England : 1993). 20: 582-92. PMID 22483106 DOI: 10.1016/J.Str.2012.02.017 |
0.439 |
|
| 2012 |
Norbury LJ, Hung A, Beckham S, Pike RN, Spithill TW, Craik CS, Choe Y, Fecondo JV, Smooker PM. Analysis of Fasciola cathepsin L5 by S2 subsite substitutions and determination of the P1-P4 specificity reveals an unusual preference. Biochimie. 94: 1119-27. PMID 22285967 DOI: 10.1016/J.Biochi.2012.01.011 |
0.36 |
|
| 2012 |
Jäger S, Kim DY, Hultquist JF, Shindo K, LaRue RS, Kwon E, Li M, Anderson BD, Yen L, Stanley D, Mahon C, Kane J, Franks-Skiba K, Cimermancic P, Burlingame A, ... ... Craik CS, et al. Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection. Nature. 481: 371-5. PMID 22190037 DOI: 10.1038/Nature10693 |
0.317 |
|
| 2012 |
Schneider EL, Lee MS, Baharuddin A, Goetz DH, Farady CJ, Ward M, Wang CI, Craik CS. A reverse binding motif that contributes to specific protease inhibition by antibodies. Journal of Molecular Biology. 415: 699-715. PMID 22154938 DOI: 10.1016/J.Jmb.2011.11.036 |
0.381 |
|
| 2011 |
Kim J, Stroud RM, Craik CS. Rapid identification of recombinant Fabs that bind to membrane proteins Methods. 55: 303-309. PMID 21958987 DOI: 10.1016/J.Ymeth.2011.09.012 |
0.305 |
|
| 2011 |
Franta Z, Sojka D, Frantova H, Dvorak J, Horn M, Srba J, Talacko P, Mares M, Schneider E, Craik CS, McKerrow JH, Caffrey CR, Kopacek P. IrCL1 - the haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus. International Journal For Parasitology. 41: 1253-62. PMID 21819989 DOI: 10.1016/J.Ijpara.2011.06.006 |
0.371 |
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| 2011 |
Lee GM, Shahian T, Baharuddin A, Gable JE, Craik CS. Enzyme inhibition by allosteric capture of an inactive conformation. Journal of Molecular Biology. 411: 999-1016. PMID 21723875 DOI: 10.1016/J.Jmb.2011.06.032 |
0.448 |
|
| 2011 |
de Poot SA, Westgeest M, Hostetter DR, Van Damme P, Plasman K, Demeyer K, Broekhuizen R, Gevaert K, Craik CS, Bovenschen N. Human and mouse granzyme M display divergent and species-specific substrate specificities. The Biochemical Journal. 437: 431-42. PMID 21564021 DOI: 10.1042/Bj20110210 |
0.406 |
|
| 2011 |
Craik CS, Page MJ, Madison EL. Proteases as therapeutics. The Biochemical Journal. 435: 1-16. PMID 21406063 DOI: 10.1042/Bj20100965 |
0.305 |
|
| 2011 |
Brown CM, Ray M, Eroy-Reveles AA, Egea P, Tajon C, Craik CS. Peptide length and leaving-group sterics influence potency of peptide phosphonate protease inhibitors. Chemistry & Biology. 18: 48-57. PMID 21276938 DOI: 10.1016/J.Chembiol.2010.11.007 |
0.433 |
|
| 2011 |
Swenerton RK, Zhang S, Sajid M, Medzihradszky KF, Craik CS, Kelly BL, McKerrow JH. The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion. The Journal of Biological Chemistry. 286: 429-40. PMID 20961853 DOI: 10.1074/Jbc.M110.138313 |
0.322 |
|
| 2010 |
Farady CJ, Craik CS. Mechanisms of macromolecular protease inhibitors. Chembiochem : a European Journal of Chemical Biology. 11: 2341-6. PMID 21053238 DOI: 10.1002/Cbic.201000442 |
0.468 |
|
| 2010 |
Na BK, Bae YA, Zo YG, Choe Y, Kim SH, Desai PV, Avery MA, Craik CS, Kim TS, Rosenthal PJ, Kong Y. Biochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4. Plos Neglected Tropical Diseases. 4: e849. PMID 20967286 DOI: 10.1371/Journal.Pntd.0000849 |
0.339 |
|
| 2010 |
Raymond WW, Trivedi NN, Makarova A, Ray M, Craik CS, Caughey GH. How immune peptidases change specificity: cathepsin G gained tryptic function but lost efficiency during primate evolution. Journal of Immunology (Baltimore, Md. : 1950). 185: 5360-8. PMID 20889553 DOI: 10.4049/Jimmunol.1002292 |
0.371 |
|
| 2010 |
Cruz CE, Fogaça AC, Nakayasu ES, Angeli CB, Belmonte R, Almeida IC, Miranda A, Miranda MT, Tanaka AS, Braz GR, Craik CS, Schneider E, Caffrey CR, Daffre S. Characterization of proteinases from the midgut of Rhipicephalus (Boophilus) microplus involved in the generation of antimicrobial peptides. Parasites & Vectors. 3: 63. PMID 20663211 DOI: 10.1186/1756-3305-3-63 |
0.3 |
|
| 2010 |
Barkan DT, Hostetter DR, Mahrus S, Pieper U, Wells JA, Craik CS, Sali A. Prediction of protease substrates using sequence and structure features. Bioinformatics (Oxford, England). 26: 1714-22. PMID 20505003 DOI: 10.1093/Bioinformatics/Btq267 |
0.388 |
|
| 2010 |
Duriseti S, Goetz DH, Hostetter DR, LeBeau AM, Wei Y, Craik CS. Antagonistic anti-urokinase plasminogen activator receptor (uPAR) antibodies significantly inhibit uPAR-mediated cellular signaling and migration. The Journal of Biological Chemistry. 285: 26878-88. PMID 20501655 DOI: 10.1074/Jbc.M109.077677 |
0.306 |
|
| 2010 |
He C, Nora GP, Schneider EL, Kerr ID, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd SE, Hruz P, Cobo ER, Le C, Liu WT, Eckmann L, Dorrestein PC, ... ... Craik CS, et al. A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. The Journal of Biological Chemistry. 285: 18516-27. PMID 20378535 DOI: 10.1074/Jbc.M109.086181 |
0.392 |
|
| 2010 |
Ohol YM, Goetz DH, Chan K, Shiloh MU, Craik CS, Cox JS. Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence. Cell Host & Microbe. 7: 210-20. PMID 20227664 DOI: 10.1016/J.Chom.2010.02.006 |
0.309 |
|
| 2010 |
Stoop AA, Joshi RV, Eggers CT, Craik CS. Analysis of an engineered plasma kallikrein inhibitor and its effect on contact activation. Biological Chemistry. 391: 425-33. PMID 20180651 DOI: 10.1515/Bc.2010.047 |
0.41 |
|
| 2010 |
Camerer E, Barker A, Duong DN, Ganesan R, Kataoka H, Cornelissen I, Darragh MR, Hussain A, Zheng YW, Srinivasan Y, Brown C, Xu SM, Regard JB, Lin CY, Craik CS, et al. Local protease signaling contributes to neural tube closure in the mouse embryo. Developmental Cell. 18: 25-38. PMID 20152175 DOI: 10.1016/J.Devcel.2009.11.014 |
0.309 |
|
| 2010 |
Darragh MR, Schneider EL, Lou J, Phojanakong PJ, Farady CJ, Marks JD, Hann BC, Craik CS. Tumor detection by imaging proteolytic activity. Cancer Research. 70: 1505-12. PMID 20145119 DOI: 10.1158/0008-5472.Can-09-1640 |
0.327 |
|
| 2010 |
Sathler PC, Craik CS, Takeuchi T, Zingali RB, Castro HC. Engineering ecotin for identifying proteins with a trypsin fold. Applied Biochemistry and Biotechnology. 160: 2355-65. PMID 19728173 DOI: 10.1007/S12010-009-8711-Z |
0.444 |
|
| 2009 |
Shahian T, Lee GM, Lazic A, Arnold LA, Velusamy P, Roels CM, Guy RK, Craik CS. Inhibition of a viral enzyme by a small-molecule dimer disruptor. Nature Chemical Biology. 5: 640-6. PMID 19633659 DOI: 10.1038/Nchembio.192 |
0.391 |
|
| 2009 |
Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC, Caffrey CR, Legac J, Hansell E, McKerrow JH, Craik CS, Rosenthal PJ, Brinen LS. Vinyl sulfones as antiparasitic agents and a structural basis for drug design. The Journal of Biological Chemistry. 284: 25697-703. PMID 19620707 DOI: 10.1074/Jbc.M109.014340 |
0.379 |
|
| 2009 |
Mahon CS, O'Donoghue AJ, Goetz DH, Murray PG, Craik CS, Tuohy MG. Characterization of a multimeric, eukaryotic prolyl aminopeptidase: an inducible and highly specific intracellular peptidase from the non-pathogenic fungus Talaromyces emersonii. Microbiology (Reading, England). 155: 3673-82. PMID 19556294 DOI: 10.1099/Mic.0.030940-0 |
0.436 |
|
| 2009 |
Dvorák J, Mashiyama ST, Sajid M, Braschi S, Delcroix M, Schneider EL, McKerrow WH, Bahgat M, Hansell E, Babbitt PC, Craik CS, McKerrow JH, Caffrey CR. SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni. Plos Neglected Tropical Diseases. 3: e449. PMID 19488406 DOI: 10.1371/Journal.Pntd.0000449 |
0.399 |
|
| 2009 |
Farady CJ, Sellers BD, Jacobson MP, Craik CS. Improving the species cross-reactivity of an antibody using computational design. Bioorganic & Medicinal Chemistry Letters. 19: 3744-7. PMID 19477127 DOI: 10.1016/J.Bmcl.2009.05.005 |
0.307 |
|
| 2009 |
Schneider EL, Craik CS. Positional scanning synthetic combinatorial libraries for substrate profiling. Methods in Molecular Biology (Clifton, N.J.). 539: 59-78. PMID 19377970 DOI: 10.1007/978-1-60327-003-8_4 |
0.381 |
|
| 2009 |
Lee GM, Craik CS. Trapping moving targets with small molecules. Science (New York, N.Y.). 324: 213-5. PMID 19359579 DOI: 10.1126/Science.1169378 |
0.317 |
|
| 2009 |
Subramanian S, Hardt M, Choe Y, Niles RK, Johansen EB, Legac J, Gut J, Kerr ID, Craik CS, Rosenthal PJ. Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3. Plos One. 4: e5156. PMID 19357776 DOI: 10.1371/Journal.Pone.0005156 |
0.425 |
|
| 2009 |
Lilla JN, Joshi RV, Craik CS, Werb Z. Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation, and stromal remodeling during mammary gland involution. The Journal of Biological Chemistry. 284: 13792-803. PMID 19297327 DOI: 10.1074/Jbc.M900508200 |
0.346 |
|
| 2009 |
Liz MA, Fleming CE, Nunes AF, Almeida MR, Mar FM, Choe Y, Craik CS, Powers JC, Bogyo M, Sousa MM. Substrate specificity of transthyretin: identification of natural substrates in the nervous system. The Biochemical Journal. 419: 467-74. PMID 19138167 DOI: 10.1042/Bj20082090 |
0.408 |
|
| 2009 |
Dolecková K, Kasný M, Mikes L, Cartwright J, Jedelský P, Schneider EL, Dvorák J, Mountford AP, Craik CS, Horák P. The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti. International Journal For Parasitology. 39: 201-11. PMID 18708063 DOI: 10.1016/J.Ijpara.2008.06.010 |
0.383 |
|
| 2009 |
Lim MD, Craik CS. Using specificity to strategically target proteases. Bioorganic & Medicinal Chemistry. 17: 1094-100. PMID 18434168 DOI: 10.1016/J.Bmc.2008.03.068 |
0.401 |
|
| 2008 |
Raorane DA, Lim MD, Chen FF, Craik CS, Majumdar A. Quantitative and label-free technique for measuring protease activity and inhibition using a microfluidic cantilever array. Nano Letters. 8: 2968-74. PMID 18720973 DOI: 10.1021/Nl8019455 |
0.322 |
|
| 2008 |
O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey CR, McKerrow JH. A parasite cysteine protease is key to host protein degradation and iron acquisition. The Journal of Biological Chemistry. 283: 28934-43. PMID 18701454 DOI: 10.1074/Jbc.M805824200 |
0.384 |
|
| 2008 |
O'Donoghue AJ, Mahon CS, Goetz DH, O'Malley JM, Gallagher DM, Zhou M, Murray PG, Craik CS, Tuohy MG. Inhibition of a secreted glutamic peptidase prevents growth of the fungus Talaromyces emersonii. The Journal of Biological Chemistry. 283: 29186-95. PMID 18687686 DOI: 10.1074/Jbc.M802366200 |
0.403 |
|
| 2008 |
Debela M, Beaufort N, Magdolen V, Schechter NM, Craik CS, Schmitt M, Bode W, Goettig P. Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7. Biological Chemistry. 389: 623-32. PMID 18627343 DOI: 10.1515/Bc.2008.075 |
0.406 |
|
| 2008 |
Lucas JJ, Hayes GR, Kalsi HK, Gilbert RO, Choe Y, Craik CS, Singh BN. Characterization of a cysteine protease from Tritrichomonas foetus that induces host-cell apoptosis. Archives of Biochemistry and Biophysics. 477: 239-43. PMID 18554499 DOI: 10.1016/J.Abb.2008.05.018 |
0.329 |
|
| 2008 |
Farady CJ, Egea PF, Schneider EL, Darragh MR, Craik CS. Structure of an Fab-protease complex reveals a highly specific non-canonical mechanism of inhibition. Journal of Molecular Biology. 380: 351-60. PMID 18514224 DOI: 10.1016/J.Jmb.2008.05.009 |
0.447 |
|
| 2008 |
DuBois KN, Abodeely M, Sakanari J, Craik CS, Lee M, McKerrow JH, Sajid M. Identification of the major cysteine protease of Giardia and its role in encystation. The Journal of Biological Chemistry. 283: 18024-31. PMID 18445589 DOI: 10.1074/Jbc.M802133200 |
0.36 |
|
| 2008 |
Stack CM, Caffrey CR, Donnelly SM, Seshaadri A, Lowther J, Tort JF, Collins PR, Robinson MW, Xu W, McKerrow JH, Craik CS, Geiger SR, Marion R, Brinen LS, Dalton JP. Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica. The Journal of Biological Chemistry. 283: 9896-908. PMID 18160404 DOI: 10.1074/Jbc.M708521200 |
0.426 |
|
| 2008 |
Darragh MR, Bhatt AS, Craik CS. MT-SP1 proteolysis and regulation of cell-microenvironment interactions. Frontiers in Bioscience : a Journal and Virtual Library. 13: 528-39. PMID 17981566 DOI: 10.2741/2698 |
0.62 |
|
| 2007 |
Lazic A, Goetz DH, Nomura AM, Marnett AB, Craik CS. Substrate modulation of enzyme activity in the herpesvirus protease family. Journal of Molecular Biology. 373: 913-23. PMID 17870089 DOI: 10.1016/J.Jmb.2007.07.073 |
0.461 |
|
| 2007 |
Liu GL, Rosa-Bauza YT, Salisbury CM, Craik C, Ellman JA, Chen FF, Lee LP. Peptide-nanoparticle hybrid SERS probes for optical detection of protease activity. Journal of Nanoscience and Nanotechnology. 7: 2323-30. PMID 17663247 DOI: 10.1166/Jnn.2007.444 |
0.306 |
|
| 2007 |
Hostetter DR, Loeb CR, Chu F, Craik CS. Hip is a pro-survival substrate of granzyme B. The Journal of Biological Chemistry. 282: 27865-74. PMID 17620340 DOI: 10.1074/Jbc.M704312200 |
0.324 |
|
| 2007 |
Goetz DH, Choe Y, Hansell E, Chen YT, McDowell M, Jonsson CB, Roush WR, McKerrow J, Craik CS. Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus. Biochemistry. 46: 8744-52. PMID 17605471 DOI: 10.1021/Bi0621415 |
0.396 |
|
| 2007 |
Meléndez-López SG, Herdman S, Hirata K, Choi MH, Choe Y, Craik C, Caffrey CR, Hansell E, Chávez-Munguía B, Yen TC, Roush WR, McKerrow J, Eckmann L, Guo J, Stanley SL, et al. Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model Eukaryotic Cell. 6: 1130-1136. PMID 17513563 DOI: 10.1128/Ec.00094-07 |
0.397 |
|
| 2007 |
Farady CJ, Sun J, Darragh MR, Miller SM, Craik CS. The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1). Journal of Molecular Biology. 369: 1041-51. PMID 17475279 DOI: 10.1016/J.Jmb.2007.03.078 |
0.424 |
|
| 2007 |
Bhatt AS, Welm A, Farady CJ, Vásquez M, Wilson K, Craik CS. Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway. Proceedings of the National Academy of Sciences of the United States of America. 104: 5771-6. PMID 17389401 DOI: 10.1073/Pnas.0606514104 |
0.589 |
|
| 2007 |
Sojka D, Hajdusek O, Dvorák J, Sajid M, Franta Z, Schneider EL, Craik CS, Vancová M, Buresová V, Bogyo M, Sexton KB, McKerrow JH, Caffrey CR, Kopácek P. IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus. International Journal For Parasitology. 37: 713-24. PMID 17336985 DOI: 10.1016/J.Ijpara.2006.12.020 |
0.38 |
|
| 2007 |
Bhatt AS, Welm A, Vásquez M, Wilson K, Craik CS. Using Coordinate Expression and Functional Profiling to Identify an Extracellular Proteolytic Signaling Pathway The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A249-C |
0.525 |
|
| 2006 |
Park K, Kuechle MK, Choe Y, Craik CS, Lawrence OT, Presland RB. Expression and characterization of constitutively active human caspase-14. Biochemical and Biophysical Research Communications. 347: 941-8. PMID 16854378 DOI: 10.1016/J.Bbrc.2006.06.156 |
0.339 |
|
| 2006 |
Castro HC, Monteiro RQ, Assafim M, Loureiro NIV, Craik C, Zingali RB. Ecotin modulates thrombin activity through exosite-2 interactions The International Journal of Biochemistry & Cell Biology. 38: 1893-1900. PMID 16843700 DOI: 10.1016/J.Biocel.2006.05.001 |
0.424 |
|
| 2006 |
Debela M, Magdolen V, Schechter N, Valachova M, Lottspeich F, Craik CS, Choe Y, Bode W, Goettig P. Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences. The Journal of Biological Chemistry. 281: 25678-88. PMID 16740631 DOI: 10.1074/Jbc.M602372200 |
0.379 |
|
| 2006 |
Baird TT, Wright WD, Craik CS. Conversion of trypsin to a functional threonine protease. Protein Science : a Publication of the Protein Society. 15: 1229-38. PMID 16672242 DOI: 10.1110/Ps.062179006 |
0.443 |
|
| 2006 |
Nomura AM, Marnett AB, Shimba N, Dötsch V, Craik CS. One functional switch mediates reversible and irreversible inactivation of a herpesvirus protease. Biochemistry. 45: 3572-9. PMID 16533039 DOI: 10.1021/Bi0523658 |
0.443 |
|
| 2006 |
Choe Y, Leonetti F, Greenbaum DC, Lecaille F, Bogyo M, Brömme D, Ellman JA, Craik CS. Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities. The Journal of Biological Chemistry. 281: 12824-32. PMID 16520377 DOI: 10.1074/Jbc.M513331200 |
0.451 |
|
| 2005 |
Nomura AM, Marnett AB, Shimba N, Dötsch V, Craik CS. Induced structure of a helical switch as a mechanism to regulate enzymatic activity. Nature Structural & Molecular Biology. 12: 1019-20. PMID 16244665 DOI: 10.1038/Nsmb1006 |
0.401 |
|
| 2005 |
Bhatt AS, Erdjument-Bromage H, Tempst P, Craik CS, Moasser MM. Adhesion signaling by a novel mitotic substrate of src kinases. Oncogene. 24: 5333-43. PMID 16007225 DOI: 10.1038/Sj.Onc.1208582 |
0.558 |
|
| 2005 |
Herter S, Piper DE, Aaron W, Gabriele T, Cutler G, Cao P, Bhatt AS, Choe Y, Craik CS, Walker N, Meininger D, Hoey T, Austin RJ. Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers. The Biochemical Journal. 390: 125-36. PMID 15839837 DOI: 10.1042/Bj20041955 |
0.652 |
|
| 2005 |
Choe Y, Brinen LS, Price MS, Engel JC, Lange M, Grisostomi C, Weston SG, Pallai PV, Cheng H, Hardy LW, Hartsough DS, McMakin M, Tilton RF, Baldino CM, Craik CS. Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease. Bioorganic & Medicinal Chemistry. 13: 2141-56. PMID 15727867 DOI: 10.1016/J.Bmc.2004.12.053 |
0.332 |
|
| 2005 |
Marnett AB, Craik CS. Papa's got a brand new tag: advances in identification of proteases and their substrates. Trends in Biotechnology. 23: 59-64. PMID 15661339 DOI: 10.1016/J.Tibtech.2004.12.010 |
0.401 |
|
| 2005 |
Matsumura M, Bhatt AS, Andress D, Clegg N, Takayama TK, Craik CS, Nelson PS. Substrates of the prostate-specific serine protease prostase/KLK4 defined by positional-scanning peptide libraries. The Prostate. 62: 1-13. PMID 15389820 DOI: 10.1002/Pros.20101 |
0.628 |
|
| 2004 |
Mahrus S, Kisiel W, Craik CS. Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B Journal of Biological Chemistry. 279: 54275-54282. PMID 15494398 DOI: 10.1074/Jbc.M411482200 |
0.37 |
|
| 2004 |
Williamson AL, Lecchi P, Turk BE, Choe Y, Hotez PJ, McKerrow JH, Cantley LC, Sajid M, Craik CS, Loukas A. A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms. The Journal of Biological Chemistry. 279: 35950-7. PMID 15199048 DOI: 10.1074/Jbc.M405842200 |
0.401 |
|
| 2004 |
Shimba N, Nomura AM, Marnett AB, Craik CS. Herpesvirus protease inhibition by dimer disruption. Journal of Virology. 78: 6657-65. PMID 15163756 DOI: 10.1128/Jvi.78.12.6657-6665.2004 |
0.398 |
|
| 2004 |
Ruggles SW, Fletterick RJ, Craik CS. Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity. The Journal of Biological Chemistry. 279: 30751-9. PMID 15123647 DOI: 10.1074/Jbc.M400949200 |
0.422 |
|
| 2004 |
Marnett AB, Nomura AM, Shimba N, Ortiz de Montellano PR, Craik CS. Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 101: 6870-5. PMID 15118083 DOI: 10.1073/Pnas.0401613101 |
0.466 |
|
| 2004 |
Eggers CT, Murray IA, Delmar VA, Day AG, Craik CS. The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase. The Biochemical Journal. 379: 107-18. PMID 14705961 DOI: 10.1042/Bj20031790 |
0.369 |
|
| 2004 |
Byoung-Kuk NA, Shenai BR, Sijwali PS, Choe Y, Pandey KC, Singh A, Craik CS, Rosenthal PJ. Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax Biochemical Journal. 378: 529-538. PMID 14629194 DOI: 10.1042/Bj20031487 |
0.414 |
|
| 2003 |
Stoop AA, Craik CS. Engineering of a macromolecular scaffold to develop specific protease inhibitors Nature Biotechnology. 21: 1063-1068. PMID 12923547 DOI: 10.1038/Nbt860 |
0.402 |
|
| 2003 |
Bell JK, Goetz DH, Mahrus S, Harris JL, Fletterick RJ, Craik CS. The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity. Nature Structural Biology. 10: 527-34. PMID 12819769 DOI: 10.1038/Nsb944 |
0.47 |
|
| 2003 |
Raymond WW, Ruggles SW, Craik CS, Caughey GH. Albumin is a substrate of human chymase. Prediction by combinatorial peptide screening and development of a selective inhibitor based on the albumin cleavage site. The Journal of Biological Chemistry. 278: 34517-24. PMID 12815038 DOI: 10.1074/Jbc.M304087200 |
0.458 |
|
| 2003 |
Bhatt AS, Takeuchi T, Ylstra B, Ginzinger D, Albertson D, Shuman MA, Craik CS. Quantitation of membrane type serine protease 1 (MT-SP1) in transformed and normal cells Biological Chemistry. 384: 257-266. PMID 12675519 DOI: 10.1515/Bc.2003.029 |
0.568 |
|
| 2003 |
Sun J, Pons J, Craik CS. Potent and selective inhibition of membrane-type serine protease 1 by human single-chain antibodies. Biochemistry. 42: 892-900. PMID 12549907 DOI: 10.1021/Bi026878F |
0.37 |
|
| 2003 |
Leiting B, Pryor KD, Wu JK, Marsilio F, Patel RA, Craik CS, Ellman JA, Cummings RT, Thornberry NA. Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII. The Biochemical Journal. 371: 525-32. PMID 12529175 DOI: 10.1042/Bj20021643 |
0.416 |
|
| 2002 |
Barrios AM, Craik CS. Scanning the prime-site substrate specificity of proteolytic enzymes: a novel assay based on ligand-enhanced lanthanide ion fluorescence. Bioorganic & Medicinal Chemistry Letters. 12: 3619-23. PMID 12443789 DOI: 10.1016/S0960-894X(02)00786-2 |
0.431 |
|
| 2002 |
Singh A, Shenai BR, Choe Y, Gut J, Sijwali PS, Craik CS, Rosenthal PJ. Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites Biochemical Journal. 368: 273-281. PMID 12169096 DOI: 10.1042/Bj20020753 |
0.424 |
|
| 2002 |
Lecaille F, Choe Y, Brandt W, Li Z, Craik CS, Brömme D. Selective inhibition of the collagenolytic activity of human cathepsin K by altering its S2 subsite specificity Biochemistry. 41: 8447-8454. PMID 12081494 DOI: 10.1021/Bi025638X |
0.373 |
|
| 2002 |
Salter JP, Choe Y, Albrecht H, Franklin C, Lim KC, Craik CS, McKerrow JH. Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes. The Journal of Biological Chemistry. 277: 24618-24. PMID 11986325 DOI: 10.1074/Jbc.M202364200 |
0.352 |
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| 2002 |
Mathieu MA, Bogyo M, Caffrey CR, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH. Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries Molecular and Biochemical Parasitology. 121: 99-105. PMID 11985866 DOI: 10.1016/S0166-6851(02)00026-9 |
0.346 |
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| 2002 |
Laboissière MC, Young MM, Pinho RG, Todd S, Fletterick RJ, Kuntz I, Craik CS. Computer-assisted mutagenesis of ecotin to engineer its secondary binding site for urokinase inhibition. The Journal of Biological Chemistry. 277: 26623-31. PMID 11959867 DOI: 10.1074/Jbc.M203076200 |
0.408 |
|
| 2002 |
Reiling KK, Endres NF, Dauber DS, Craik CS, Stroud RM. Anisotropic dynamics of the JE-2147-HIV protease complex: drug resistance and thermodynamic binding mode examined in a 1.09 A structure. Biochemistry. 41: 4582-94. PMID 11926820 DOI: 10.1021/Bi011781Z |
0.34 |
|
| 2002 |
Maly DJ, Leonetti F, Backes BJ, Dauber DS, Harris JL, Craik CS, Ellman JA. Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore. The Journal of Organic Chemistry. 67: 910-5. PMID 11856036 DOI: 10.1021/Jo016140O |
0.314 |
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| 2002 |
Wang B, Brown KC, Lodder M, Craik CS, Hecht SM. Chemically mediated site-specific proteolysis. Alteration of protein-protein interaction. Biochemistry. 41: 2805-13. PMID 11851428 DOI: 10.1021/Bi011762P |
0.428 |
|
| 2002 |
Pray TR, Reiling KK, Demirjian BG, Craik CS. Conformational change coupling the dimerization and activation of KSHV protease Biochemistry. 41: 1474-1482. PMID 11814340 DOI: 10.1021/Bi011753G |
0.364 |
|
| 2002 |
Dauber DS, Ziermann R, Parkin N, Maly DJ, Mahrus S, Harris JL, Ellman JA, Petropoulos C, Craik CS. Altered substrate specificity of drug-resistant human immunodeficiency virus type 1 protease. Journal of Virology. 76: 1359-68. PMID 11773410 DOI: 10.1128/Jvi.76.3.1359-1368.2002 |
0.397 |
|
| 2001 |
Person MD, Brown KC, Mahrus S, Craik CS, Burlingame AL. Novel inter-protein cross-link identified in the GGH-ecotin D137Y dimer Protein Science. 10: 1549-1562. PMID 11468352 DOI: 10.1110/Ps.Ps.46601 |
0.35 |
|
| 2001 |
Harris JL, Niles A, Burdick K, Maffitt M, Backes BJ, Ellman JA, Kuntz I, Haak-Frendscho M, Craik CS. Definition of the extended substrate specificity determinants for beta-tryptases I and II. The Journal of Biological Chemistry. 276: 34941-7. PMID 11438529 DOI: 10.1074/Jbc.M102997200 |
0.437 |
|
| 2001 |
Castro HC, Silva DM, Craik C, Zingali RB. Structural features of a snake venom thrombin-like enzyme: thrombin and trypsin on a single catalytic platform? Biochimica Et Biophysica Acta. 1547: 183-195. PMID 11410274 DOI: 10.1016/S0167-4838(01)00177-7 |
0.473 |
|
| 2001 |
Eggers CT, Wang SX, Fletterick RJ, Craik CS. The role of ecotin dimerization in protease inhibition. Journal of Molecular Biology. 308: 975-91. PMID 11352586 DOI: 10.1006/Jmbi.2001.4754 |
0.43 |
|
| 2001 |
Nealon K, Newcomb WW, Pray TR, Craik CS, Brown JC, Kedes DH. Lytic replication of Kaposi's sarcoma-associated herpesvirus results in the formation of multiple capsid species: isolation and molecular characterization of A, B, and C capsids from a gammaherpesvirus. Journal of Virology. 75: 2866-78. PMID 11222712 DOI: 10.1128/Jvi.75.6.2866-2878.2001 |
0.314 |
|
| 2000 |
Reiling KK, Pray TR, Craik CS, Stroud RM. Functional consequences of the Kaposi's sarcoma-associated herpesvirus protease structure: regulation of activity and dimerization by conserved structural elements. Biochemistry. 39: 12796-803. PMID 11041844 DOI: 10.1021/Bi001019H |
0.413 |
|
| 2000 |
Waugh SM, Harris JL, Fletterick R, Craik CS. The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity Nature Structural Biology. 7: 762-765. PMID 10966646 DOI: 10.1038/78992 |
0.422 |
|
| 2000 |
Harris JL, Backes BJ, Leonetti F, Mahrus S, Ellman JA, Craik CS. Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries. Proceedings of the National Academy of Sciences of the United States of America. 97: 7754-9. PMID 10869434 DOI: 10.1073/Pnas.140132697 |
0.436 |
|
| 2000 |
Gillmor SA, Takeuchi T, Yang SQ, Craik CS, Fletterick RJ. Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases. Journal of Molecular Biology. 299: 993-1003. PMID 10843853 DOI: 10.1006/Jmbi.2000.3812 |
0.401 |
|
| 2000 |
Takeuchi T, Harris JL, Huang W, Yan KW, Coughlin SR, Craik CS. Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates. The Journal of Biological Chemistry. 275: 26333-42. PMID 10831593 DOI: 10.1074/Jbc.M002941200 |
0.379 |
|
| 2000 |
Todd S, Anderson CG, Jolly DJ, Craik CS. HIV protease as a target for retrovirus vector-mediated gene therapy Biochimica Et Biophysica Acta - Protein Structure and Molecular Enzymology. 1477: 168-188. PMID 10708857 DOI: 10.1016/S0167-4838(99)00272-1 |
0.372 |
|
| 2000 |
Rozzelle JE, Dauber DS, Todd S, Kelley R, Craik CS. Macromolecular inhibitors of HIV-1 protease. Characterization of designed heterodimers Journal of Biological Chemistry. 275: 7080-7086. PMID 10702274 DOI: 10.1074/Jbc.275.10.7080 |
0.3 |
|
| 2000 |
Backes BJ, Harris JL, Leonetti F, Craik CS, Ellman JA. Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin. Nature Biotechnology. 18: 187-93. PMID 10657126 DOI: 10.1038/72642 |
0.381 |
|
| 2000 |
Todd S, Laboissière MCA, Craik CS. Yeast two-hybrid assay for examining human immunodeficiency virus protease heterodimer formation with dominant-negative inhibitors and multidrug-resistant variants Analytical Biochemistry. 277: 247-253. PMID 10625514 DOI: 10.1006/Abio.1999.4388 |
0.339 |
|
| 2000 |
Backes BJ, Harris JL, Leonetti F, Craik CS, Ellman JA. Erratum: Erratum to “Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin” Nature Biotechnology. 18: 559-559. DOI: 10.1038/75441 |
0.365 |
|
| 2000 |
Wang B, Lodder M, Zhou J, Baird TT, Brown KC, Craik CS, Hecht SM. Chemically mediated site-specific cleavage of proteins [9] Journal of the American Chemical Society. 122: 7402-7403. DOI: 10.1021/Ja0002262 |
0.324 |
|
| 2000 |
Harris JL, Craik CS. Proteases Cell. 101: 136-137. DOI: 10.1016/S0092-8674(00)80815-6 |
0.375 |
|
| 2000 |
Baird T, Wang B, Lodder M, Hecht SM, Craik CS. Generation of active trypsin by chemical cleavage Tetrahedron. 56: 9477-9485. DOI: 10.1016/S0040-4020(00)00832-2 |
0.398 |
|
| 1999 |
Takeuchi T, Shuman MA, Craik CS. Reverse biochemistry: Use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue Proceedings of the National Academy of Sciences of the United States of America. 96: 11054-11061. PMID 10500122 DOI: 10.1073/Pnas.96.20.11054 |
0.382 |
|
| 1999 |
Pray TR, Nomura AM, Pennington MW, Craik CS. Auto-inactivation by cleavage within the dimer interface of Kaposi's sarcoma-associated herpesvirus protease Journal of Molecular Biology. 289: 197-203. PMID 10366498 DOI: 10.1006/Jmbi.1999.2791 |
0.463 |
|
| 1998 |
Harris JL, Peterson EP, Hudig D, Thornberry NA, Craik CS. Definition and redesign of the extended substrate specificity of granzyme B Journal of Biological Chemistry. 273: 27364-27373. PMID 9765264 DOI: 10.1074/Jbc.273.42.27364 |
0.383 |
|
| 1998 |
Harris JL, Craik CS. Engineering enzyme specificity Current Opinion in Chemical Biology. 2: 127-132. PMID 9667915 DOI: 10.1016/S1367-5931(98)80044-6 |
0.341 |
|
| 1998 |
Yang SQ, Craik CS. Engineering bidentate macromolecular inhibitors for trypsin and urokinase-type plasminogen activator Journal of Molecular Biology. 279: 1001-1011. PMID 9642077 DOI: 10.1006/Jmbi.1998.1749 |
0.692 |
|
| 1998 |
Yang SQ, Wang CI, Gillmor SA, Fletterick RJ, Craik CS. Ecotin: a serine protease inhibitor with two distinct and interacting binding sites. Journal of Molecular Biology. 279: 945-57. PMID 9642073 DOI: 10.1006/Jmbi.1998.1748 |
0.677 |
|
| 1998 |
Dauber DS, McPhee F, Ünal A, Craik CS. Optimization of a macromolecular inhibitor of HIV-1 protease Advances in Experimental Medicine and Biology. 436: 65-70. PMID 9561201 DOI: 10.1007/978-1-4615-5373-1_9 |
0.391 |
|
| 1998 |
Craik CS, Babé LM, Dauber D, McPhee F, Rosé J, Ünal A. Engineering catalytically defective forms of HIV protease to modulate its activity Advances in Experimental Medicine and Biology. 436: 31-39. PMID 9561196 DOI: 10.1007/978-1-4615-5373-1_4 |
0.337 |
|
| 1998 |
Brown KC, Yu Z, Burlingame AL, Craik CS. Determining protein - Protein interactions by oxidative cross-linking of a glycine-glycine-histidine fusion protein Biochemistry. 37: 4397-4406. PMID 9521759 DOI: 10.1021/Bi9728046 |
0.31 |
|
| 1998 |
Rose RB, Craik CS, Stroud RM. Domain flexibility in retroviral proteases: structural implications for drug resistant mutations. Biochemistry. 37: 2607-21. PMID 9485411 DOI: 10.1021/Bi9716074 |
0.388 |
|
| 1997 |
Caldera PS, Yu Z, Knegtel RM, McPhee F, Burlingame AL, Craik CS, Kuntz ID, Ortiz de Montellano PR. Alkylation of a catalytic aspartate group of the SIV protease by an epoxide inhibitor. Bioorganic & Medicinal Chemistry. 5: 2019-27. PMID 9416419 DOI: 10.1016/S0968-0896(97)00131-4 |
0.436 |
|
| 1997 |
Babé LM, Craik CS. Viral proteases: Evolution of diverse structural motifs to optimize function Cell. 91: 427-430. PMID 9390549 DOI: 10.1016/S0092-8674(00)80426-2 |
0.41 |
|
| 1997 |
Rutenber EE, De Voss JJ, Hoffman L, Stroud RM, Lee KH, Alvarez J, McPhee F, Craik C, Ortiz De Montellano PR. The discovery, characterization and crystallographically determined binding mode of an FMOC-containing inhibitor of HIV-1 protease Bioorganic and Medicinal Chemistry. 5: 1311-1320. PMID 9377091 DOI: 10.1016/S0968-0896(97)00078-3 |
0.385 |
|
| 1997 |
Perona JJ, Craik CS. Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold Journal of Biological Chemistry. 272: 29987-29990. PMID 9374470 DOI: 10.1074/Jbc.272.48.29987 |
0.688 |
|
| 1997 |
Ünal A, Pray TR, Lagunoff M, Pennington MW, Ganem D, Craik CS. The protease and the assembly protein of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) Journal of Virology. 71: 7030-7038. PMID 9261433 DOI: 10.1128/Jvi.71.9.7030-7038.1997 |
0.441 |
|
| 1997 |
Gillmor SA, Craik CS, Fletterick RJ. Structural determinants of specificity in the cysteine protease cruzain. Protein Science : a Publication of the Protein Society. 6: 1603-11. PMID 9260273 DOI: 10.1002/Pro.5560060801 |
0.444 |
|
| 1997 |
Tsu CA, Perona JJ, Fletterick RJ, Craik CS. Structural basis for the broad substrate specificity of fiddler crab collagenolytic serine protease 1. Biochemistry. 36: 5393-401. PMID 9154921 DOI: 10.1021/Bi961753U |
0.699 |
|
| 1997 |
Perona JJ, Tsu CA, Craik CS, Fletterick RJ. Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix. Biochemistry. 36: 5381-92. PMID 9154920 DOI: 10.1021/Bi9617522 |
0.673 |
|
| 1997 |
Rutenber E, Fauman EB, Keenan RJ, Fong S, Furth PS, Montellano PROd, Meng E, Kuntz ID, DeCamp DL, Salto R, Rose JR, Craik CS, Stroud RM. Structure of a non-peptide inhibitor complexed with HIV-1 protease. Developing a cycle of structure-based drug design. Journal of Biological Chemistry. 268: 15343-15346. DOI: 10.2210/Pdb2Aid/Pdb |
0.404 |
|
| 1997 |
Laboissere MCA, Yang Q, Craik CS. Macromolecular inhibition of urokinase-type plasminogen activator Faseb Journal. 11: A1397. |
0.345 |
|
| 1996 |
McPhee F, Caldera PS, Bemis GW, McDonagh AF, Kuntz ID, Craik CS. Bile pigments as HIV-1 protease inhibitors and their effects on HIV-1 viral maturation and infectivity in vitro. The Biochemical Journal. 320: 681-6. PMID 8973584 DOI: 10.1042/Bj3200681 |
0.31 |
|
| 1996 |
Gudmundsdóttir E, Spilliaert R, Yang Q, Craik CS, Bjarnason JB, Gudmundsdóttir A. Isolation and characterization of two cDNAs from Atlantic cod encoding two distinct psychrophilic elastases Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 113: 795-801. PMID 8925447 DOI: 10.1016/0305-0491(95)02109-4 |
0.378 |
|
| 1996 |
Rutenber EE, McPhee F, Kaplan AP, Gallion SL, Hogan JC, Craik CS, Stroud RM. A new class of HIV-1 protease inhibitor: The crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere Bioorganic and Medicinal Chemistry. 4: 1545-1558. PMID 8894111 DOI: 10.1016/0968-0896(96)00147-2 |
0.391 |
|
| 1996 |
Li R, Chen X, Gong B, Selzer PM, Li Z, Davidson E, Kurzban G, Miller RE, Nuzum EO, McKerrow JH, Fletterick RJ, Gillmor SA, Craik CS, Kuntz ID, Cohen FE, et al. Structure-based design of parasitic protease inhibitors. Bioorganic & Medicinal Chemistry. 4: 1421-7. PMID 8894100 DOI: 10.1016/0968-0896(96)00136-8 |
0.369 |
|
| 1996 |
McPhee F, Good AC, Kuntz ID, Craik CS. Engineering human immunodeficiency virus 1 protease heterodimers as macromolecular inhibitors of viral maturation. Proceedings of the National Academy of Sciences of the United States of America. 93: 11477-81. PMID 8876160 DOI: 10.1073/Pnas.93.21.11477 |
0.334 |
|
| 1996 |
Rose RB, Craik CS, Douglas NL, Stroud RM. Three-dimensional structures of HIV-1 and SIV protease product complexes. Biochemistry. 35: 12933-44. PMID 8841139 DOI: 10.1021/Bi9612733 |
0.384 |
|
| 1996 |
Wang CI, Yang Q, Craik CS. Phage display of proteases and macromolecular inhibitors Methods in Enzymology. 267: 52-68. PMID 8743309 DOI: 10.1016/S0076-6879(96)67005-0 |
0.362 |
|
| 1996 |
Brinen LS, Willett WS, Craik CS, Fletterick RJ. X-ray structures of a designed binding site in trypsin show metal-dependent geometry. Biochemistry. 35: 5999-6009. PMID 8634241 DOI: 10.1021/Bi9530200 |
0.324 |
|
| 1996 |
Tsu CA, Craik CS. Substrate recognition by recombinant serine collagenase 1 from Uca pugilator. The Journal of Biological Chemistry. 271: 11563-70. PMID 8626718 DOI: 10.1074/Jbc.271.19.11563 |
0.441 |
|
| 1996 |
Yu Z, Caldera P, McPhee F, De Voss JJ, Jones PR, Burlingame AL, Kuntz ID, Craik CS, Ortiz De Montellano PR. Irreversible inhibition of the HIV-1 protease: Targeting alkylating agents to the catalytic aspartate groups Journal of the American Chemical Society. 118: 5846-5856. DOI: 10.1021/Ja954069W |
0.331 |
|
| 1995 |
Willett WS, Gillmor SA, Perona JJ, Fletterick RJ, Craik CS. Engineered metal regulation of trypsin specificity Biochemistry. 34: 2172-2180. PMID 7857928 |
0.637 |
|
| 1995 |
Perona JJ, Craik CS. Structural basis of substrate specificity in the serine proteases Protein Science. 4: 337-360. PMID 7795518 DOI: 10.1002/Pro.5560040301 |
0.648 |
|
| 1995 |
Wang C, Yang Q, Craik CS. Isolation of a High Affinity Inhibitor of Urokinase-type Plasminogen Activator by Phage Display of Ecotin Journal of Biological Chemistry. 270: 12250-12256. PMID 7744876 DOI: 10.1074/Jbc.270.20.12250 |
0.448 |
|
| 1995 |
McGrath ME, Eakin AE, Engel JC, McKerrow JH, Craik CS, Fletterick RJ. The crystal structure of cruzain: a therapeutic target for Chagas' disease. Journal of Molecular Biology. 247: 251-9. PMID 7707373 DOI: 10.1006/Jmbi.1994.0137 |
0.351 |
|
| 1995 |
Corey DR, Willett WS, Coombs GS, Craik CS. Trypsin specificity increased through substrate-assisted catalysis. Biochemistry. 34: 11521-7. PMID 7547882 DOI: 10.1021/Bi00036A027 |
0.796 |
|
| 1995 |
Rosé JR, Babé LM, Craik CS. Defining the level of human immunodeficiency virus type 1 (HIV-1) protease activity required for HIV-1 particle maturation and infectivity. Journal of Virology. 69: 2751-2758. PMID 7535864 DOI: 10.1128/Jvi.69.5.2751-2758.1995 |
0.359 |
|
| 1995 |
Babé LM, Rosé J, Craik CS. Trans-dominant inhibitory human immunodeficiency virus type 1 protease monomers prevent protease activation and virion maturation. Proceedings of the National Academy of Sciences of the United States of America. 92: 10069-10073. PMID 7479728 DOI: 10.1073/Pnas.92.22.10069 |
0.324 |
|
| 1995 |
Sloane DL, Leung R, Barnett J, Craik CS, Sigal E. Conversion of human 15-lipoxygenase to an efficient 12-lipoxygenase: the side-chain geometry of amino acids 417 and 418 determine positional specificity. Protein Engineering. 8: 275-282. PMID 7479689 DOI: 10.1093/Protein/8.3.275 |
0.4 |
|
| 1995 |
Eakin AE, McKerrow JH, Craik CS. A Cysteine Protease is a Target for the Enzyme Structure-Based Design of Antiparasitic Drugs Drug Information Journal. 29: 1501S-1517S. DOI: 10.1177/00928615950290S102 |
0.362 |
|
| 1994 |
Matthews BW, Craik CS, Neurath H. Can small cyclic peptides have the activity and specificity of proteolytic enzymes? Proceedings of the National Academy of Sciences of the United States of America. 91: 4103-5. PMID 8183878 DOI: 10.1073/Pnas.91.10.4103 |
0.375 |
|
| 1994 |
Perona JJ, Hedstrom L, Wagner RL, Rutter WJ, Craik CS, Fletterick RJ. Exogenous acetate reconstitutes the enzymatic activity of trypsin Asp189Ser. Biochemistry. 33: 3252-9. PMID 8136360 DOI: 10.1021/Bi00177A016 |
0.739 |
|
| 1994 |
Sui Z, Salto R, Li J, Craik C, Ortiz de Montellano PR. Inhibition of the HIV-1 and HIV-2 proteases by curcumin and curcumin boron complexes. Bioorganic & Medicinal Chemistry. 1: 415-22. PMID 8087563 DOI: 10.1016/S0968-0896(00)82152-5 |
0.328 |
|
| 1994 |
Rosé JR, Craik CS. Structure-assisted Design of Nonpeptide Human Immunodeficiency Virus-1 Protease Inhibitors American Journal of Respiratory and Critical Care Medicine. 150. PMID 7952656 DOI: 10.1164/Ajrccm/150.6_Pt_2.S176 |
0.384 |
|
| 1993 |
Corey DR, Shiau AK, Yang Q, Janowski BA, Craik CS. Trypsin display on the surface of bacteriophage. Gene. 128: 129-34. PMID 8508953 DOI: 10.1016/0378-1119(93)90163-W |
0.579 |
|
| 1993 |
Perona JJ, Tsu CA, McGrath ME, Craik CS, Fletterick RJ. Relocating a negative charge in the binding pocket of trypsin. Journal of Molecular Biology. 230: 934-49. PMID 8478942 DOI: 10.1006/Jmbi.1993.1211 |
0.691 |
|
| 1993 |
McGrath ME, Haymore BL, Summers NL, Craik CS, Fletterick RJ. Structure of an engineered, metal-actuated switch in trypsin. Biochemistry. 32: 1914-9. PMID 8448149 DOI: 10.1021/Bi00059A005 |
0.363 |
|
| 1993 |
Perona JJ, Craik CS, Fletterick RJ. Locating the catalytic water molecule in serine proteases Science. 261: 620-622. PMID 8342029 DOI: 10.1126/Science.8342029 |
0.584 |
|
| 1993 |
Perona JJ, Evnin LB, Craik CS. A genetic selection elucidates structural determinants of arginine versus lysine specificity in trypsin Gene. 137: 121-126. PMID 8282194 DOI: 10.1016/0378-1119(93)90259-6 |
0.671 |
|
| 1993 |
Rose RB, Rosé JR, Salto R, Craik CS, Stroud RM. Structure of the protease from simian immunodeficiency virus: complex with an irreversible nonpeptide inhibitor. Biochemistry. 32: 12498-507. PMID 8241141 DOI: 10.1021/Bi00097A030 |
0.383 |
|
| 1993 |
Gudmundsdottir A, Gudmundsdottir E, Oskarsson S, Bjarnason JB, Eakin AK, Craik CS. Isolation and characterization of cDNAs from Atlantic cod encoding two different forms of trypsinogen European Journal of Biochemistry. 217: 1091-1097. PMID 8223632 DOI: 10.1111/J.1432-1033.1993.Tb18341.X |
0.356 |
|
| 1993 |
Perona JJ, Tsu CA, Craik CS, Fletterick RJ. Crystal structures of rat anionic trypsin complexed with the protein inhibitors APPI and BPTI. Journal of Molecular Biology. 230: 919-33. PMID 7683059 DOI: 10.1006/Jmbi.1993.1210 |
0.665 |
|
| 1993 |
Sui Z, Voss JJD, Decamp DL, Li J, Craik CS, Montellano PROd. Synthesis of Haloperidol Ethanedithioketal HIV-1 Protease Inhibitors: Magnesium Chloride Facilitated Addition of Grignard Reagents Synthesis. 1993: 803-808. DOI: 10.1055/S-1993-25946 |
0.312 |
|
| 1993 |
Sawyer TK, Fisher JF, Hester JB, Smith CW, Tomasselli AG, Tarpley WG, Burton PS, Hui JO, McQuade TJ, Conradi RA, Bradford VS, Liu L, Kinner JH, Tustin J, Alexander DL, ... ... Craik C, et al. Peptidomimetic inhibitors of human immunodeficiency virus protease (HIV-PR): Design, enzyme binding and selectivity, antiviral efficacy, and cell permeability properties Bioorganic and Medicinal Chemistry Letters. 3: 819-824. DOI: 10.1016/S0960-894X(00)80673-3 |
0.319 |
|
| 1993 |
Bjarnason JB, Ásgeirsson B, Kristjánsson MM, Guðmundsdóttir Á, Fox JW, Chlebowski JF, Craik CS. Characteristics, protein engineering and applications of psychrophilic marine proteinases from Atlantic cod Studies in Organic Chemistry. 47: 205-214. DOI: 10.1016/B978-0-444-89372-7.50027-0 |
0.404 |
|
| 1992 |
McGrath ME, Vásquez JR, Craik CS, Yang AS, Honig B, Fletterick RJ. Perturbing the polar environment of Asp102 in trypsin: consequences of replacing conserved Ser214. Biochemistry. 31: 3059-64. PMID 1554694 DOI: 10.1021/Bi00127A005 |
0.355 |
|
| 1992 |
Sawyer TK, Staples DJ, Liu L, Tomasselli AG, Hui JO, O'Connell K, Schostarez H, Hester JB, Moon J, Howe WJ, Smith CW, Decamp DL, Craik CS, Dunn BM, Lowther WT, et al. HIV protease (HIV PR) inhibitor structure-activity-selectivity, and active site molecular modeling of high affinity Leu [CH(OH)CH2]Val modified viral and nonviral substrate analogs International Journal of Peptide and Protein Research. 40: 274-281. PMID 1478785 DOI: 10.1111/J.1399-3011.1992.Tb00302.X |
0.329 |
|
| 1992 |
Babé LM, Rosé J, Craik CS. Synthetic "interface" peptides alter dimeric assembly of the HIV 1 and 2 proteases. Protein Science. 1: 1244-1253. PMID 1338945 DOI: 10.1002/Pro.5560011003 |
0.336 |
|
| 1992 |
Higaki JN, Fletterick RJ, Craik CS. Engineered metalloregulation in enzymes Trends in Biochemical Sciences. 17: 100-104. PMID 1329276 DOI: 10.1016/0968-0004(92)90245-5 |
0.302 |
|
| 1992 |
Corey DR, McGrath ME, Vásquez JR, Fletterick RJ, Craik CS. An alternate geometry for the catalytic triad of serine proteases Journal of the American Chemical Society. 114: 4905-4907. DOI: 10.1021/Ja00038A067 |
0.595 |
|
| 1992 |
Corey DR, Craik CS. An investigation into the minimum requirements for peptide hydrolysis by mutation of the catalytic triad of trypsin Journal of the American Chemical Society. 114: 1784-1790. DOI: 10.1021/Ja00031A037 |
0.589 |
|
| 1991 |
Tomasselli AG, Howe WJ, Hui JO, Sawyer TK, Reardon IM, DeCamp DL, Craik CS, Heinrikson RL. Calcium-free calmodulin is a substrate of proteases from human immunodeficiency viruses 1 and 2. Proteins. 10: 1-9. PMID 2062825 DOI: 10.1002/Prot.340100102 |
0.383 |
|
| 1991 |
Wilke ME, Higaki JN, Craik CS, Fletterick RJ. Crystallographic analysis of trypsin-G226A. A specificity pocket mutant of rat trypsin with altered binding and catalysis. Journal of Molecular Biology. 219: 525-32. PMID 2051486 DOI: 10.1016/0022-2836(91)90191-8 |
0.411 |
|
| 1991 |
Babe LM, Pichuantes S, Craik CS. Inhibition of HIV protease activity by heterodimer formation. Biochemistry. 30: 106-111. PMID 1988010 DOI: 10.1021/Bi00215A016 |
0.392 |
|
| 1991 |
Sloane DL, Leung R, Craik CS, Sigal E. A primary determinant for lipoxygenase positional specificity Nature. 354: 149-152. PMID 1944593 DOI: 10.1038/354149A0 |
0.358 |
|
| 1991 |
Wilke ME, Higaki JN, Craik CS, Fletterick RJ. Crystal structure of rat trypsin-S195C at -150 degrees C. Analysis of low activity of recombinant and semisynthetic thiol proteases. Journal of Molecular Biology. 219: 511-23. PMID 1904942 DOI: 10.1016/0022-2836(91)90190-H |
0.375 |
|
| 1991 |
DeCamp DL, Babé LM, Furth P, Ortiz de Montellano P, Kuntz ID, Craik CS. Structure-based inhibition of HIV-1 protease activity and viral infectivity. Advances in Experimental Medicine and Biology. 306: 489-92. PMID 1812747 DOI: 10.1007/978-1-4684-6012-4_62 |
0.357 |
|
| 1990 |
Eakin AE, Bouvier J, Sakanari JA, Craik CS, McKerrow JH. Amplification and sequencing of genomic DNA fragments encoding cysteine proteases from protozoan parasites. Molecular and Biochemical Parasitology. 39: 1-8. PMID 2406590 DOI: 10.1016/0166-6851(90)90002-4 |
0.362 |
|
| 1990 |
Evnin LB, Vasquez JR, Craik CS. Substrate specificity of trypsin investigated by using a genetic selection. Proceedings of the National Academy of Sciences of the United States of America. 87: 6659-6663. PMID 2204062 DOI: 10.1073/Pnas.87.17.6659 |
0.407 |
|
| 1990 |
DesJarlais RL, Seibel GL, Kuntz ID, Furth PS, Alvarez JC, Ortiz de Montellano PR, DeCamp DL, Babé LM, Craik CS. Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease. Proceedings of the National Academy of Sciences of the United States of America. 87: 6644-8. PMID 2204060 DOI: 10.1073/Pnas.87.17.6644 |
0.328 |
|
| 1990 |
Vanderslice P, Ballinger SM, Tam EK, Goldstein SM, Craik CS, Caughey GH. Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family. Proceedings of the National Academy of Sciences of the United States of America. 87: 3811-3815. PMID 2187193 DOI: 10.1073/Pnas.87.10.3811 |
0.324 |
|
| 1990 |
Higaki JN, Haymore BL, Chen S, Fletterick RJ, Craik CS. Regulation of serine protease activity by an engineered metal switch. Biochemistry. 29: 8582-6. PMID 2125468 DOI: 10.1021/Bi00489A012 |
0.335 |
|
| 1990 |
Ferris AL, Hizi A, Showalter SD, Pichuantes S, Babe L, Craik CS, Hughes SH. Immunologic and proteolytic analysis of HIV-1 reverse transcriptase structure Virology. 175: 456-464. PMID 1691562 DOI: 10.1016/0042-6822(90)90430-Y |
0.321 |
|
| 1989 |
Pichuantes S, Babé LM, Barr PJ, Craik CS. Recombinant HIV1 protease secreted by Saccharomyces cerevisiae correctly processes myristylated gag polyprotein. Proteins. 6: 324-337. PMID 2695931 DOI: 10.1002/Prot.340060315 |
0.421 |
|
| 1989 |
Sakanari JA, Staunton CE, Eakin AE, Craik CS, McKerrow JH. Serine proteases from nematode and protozoan parasites: isolation of sequence homologs using generic molecular probes. Proceedings of the National Academy of Sciences of the United States of America. 86: 4863-7. PMID 2662185 DOI: 10.1073/Pnas.86.13.4863 |
0.385 |
|
| 1989 |
Vasquez JR, Evnin LB, Higaki JN, Craik CS. An expression system for trypsin Journal of Cellular Biochemistry. 39: 265-276. PMID 2651464 DOI: 10.1002/Jcb.240390306 |
0.382 |
|
| 1989 |
McGrath ME, Wilke ME, Higaki JN, Craik CS, Fletterick RJ. Crystal structures of two engineered thiol trypsins. Biochemistry. 28: 9264-70. PMID 2611228 DOI: 10.1021/Bi00450A005 |
0.409 |
|
| 1989 |
Higaki JN, Evnin LB, Craik CS. Introduction of a cysteine protease active site into trypsin. Biochemistry. 28: 9256-9263. PMID 2611227 DOI: 10.1021/Bi00450A004 |
0.447 |
|
| 1989 |
Vanderslice P, Craik CS, Nadel JA, Caughey GH. Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation. Biochemistry. 28: 4148-4155. PMID 2504277 DOI: 10.1021/Bi00436A004 |
0.384 |
|
| 1988 |
Sigal E, Grunberger D, Cashman JR, Craik CS, Caughey GH, Nadel JA. Arachidonate 15-lipoxygenase from human eosinophil-enriched leukocytes: partial purification and properties. Biochemical and Biophysical Research Communications. 150: 376-83. PMID 3337718 DOI: 10.1016/0006-291X(88)90531-1 |
0.327 |
|
| 1988 |
Higaki JN, Gibson BW, Craik CS. Evolution of catalysis in the serine proteases. Cold Spring Harbor Symposia On Quantitative Biology. 52: 615-21. PMID 3331347 DOI: 10.1101/Sqb.1987.052.01.070 |
0.377 |
|
| 1988 |
Sigal E, Craik CS, Highland E, Grunberger D, Costello LL, Dixon RA, Nadel JA. Molecular cloning and primary structure of human 15-lipoxygenase. Biochemical and Biophysical Research Communications. 157: 457-64. PMID 3202857 DOI: 10.1016/S0006-291X(88)80271-7 |
0.354 |
|
| 1988 |
Sprang SR, Fletterick RJ, Gráf L, Rutter WJ, Craik CS. Studies of specificity and catalysis in trypsin by structural analysis of site-directed mutants. Critical Reviews in Biotechnology. 8: 225-36. PMID 3063392 DOI: 10.1107/S0108767387085143 |
0.623 |
|
| 1988 |
Gráf L, Hegyi G, Likó I, Hepp J, Medzihradszky K, Craik CS, Rutter WJ. Structural and functional integrity of specificity and catalytic sites of trypsin. International Journal of Peptide and Protein Research. 32: 512-8. PMID 2907752 DOI: 10.1111/J.1399-3011.1988.Tb01382.X |
0.624 |
|
| 1988 |
Powell SK, Orci L, Craik CS, Moore HP. Efficient targeting to storage granules of human proinsulins with altered propeptide domain. The Journal of Cell Biology. 106: 1843-51. PMID 2838491 DOI: 10.1083/Jcb.106.6.1843 |
0.327 |
|
| 1987 |
Fletcher TS, Alhadeff M, Craik CS, Largman C. Isolation and characterization of a cDNA encoding rat cationic trypsinogen. Biochemistry. 26: 3081-6. PMID 3607011 DOI: 10.1021/Bi00385A020 |
0.362 |
|
| 1987 |
Craik CS, Roczniak S, Sprang S, Fletterick R, Rutter W. Redesigning trypsin via genetic engineering. Journal of Cellular Biochemistry. 33: 199-211. PMID 3553217 DOI: 10.1002/Jcb.240330307 |
0.447 |
|
| 1987 |
Craik CS, Roczniak S, Largman C, Rutter WJ. The catalytic role of the active site aspartic acid in serine proteases. Science (New York, N.Y.). 237: 909-13. PMID 3303334 DOI: 10.1126/Science.3303334 |
0.6 |
|
| 1987 |
Sprang S, Standing T, Fletterick RJ, Stroud RM, Finer-Moore J, Xuong NH, Hamlin R, Rutter WJ, Craik CS. The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis. Science (New York, N.Y.). 237: 905-9. PMID 3112942 DOI: 10.1126/Science.3112942 |
0.588 |
|
| 1987 |
Graf L, Craik CS, Patthy A, Roczniak S, Fletterick RJ, Rutter WJ. Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin. Biochemistry. 26: 2616-23. PMID 3111531 DOI: 10.1021/Bi00383A031 |
0.639 |
|
| 1987 |
Ebina Y, Araki E, Taira M, Shimada F, Mori M, Craik CS, Siddle K, Pierce SB, Roth RA, Rutter WJ. Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity. Proceedings of the National Academy of Sciences of the United States of America. 84: 704-8. PMID 3101064 DOI: 10.1073/Pnas.84.3.704 |
0.489 |
|
| 1987 |
Burgess TL, Craik CS, Matsuuchi L, Kelly RB. In vitro mutagenesis of trypsinogen: role of the amino terminus in intracellular protein targeting to secretory granules. The Journal of Cell Biology. 105: 659-68. PMID 3040770 DOI: 10.1083/Jcb.105.2.659 |
0.351 |
|
| 1985 |
Gardell SJ, Craik CS, Hilvert D, Urdea MS, Rutter WJ. Site-directed mutagenesis shows that tyrosine 248 of carboxypeptidase A does not play a crucial role in catalysis Nature. 317: 551-555. PMID 3840231 DOI: 10.1038/317551A0 |
0.606 |
|
| 1985 |
Craik CS, Largman C, Fletcher T, Roczniak S, Barr PJ, Fletterick R, Rutter WJ. Redesigning trypsin: Alteration of substrate specificity Science. 228: 291-297. PMID 3838593 DOI: 10.1126/Science.3838593 |
0.631 |
|
| 1984 |
Honey NK, Sakaguchi AY, Lalley PA, Quinto C, MacDonald RJ, Craik C, Bell GI, Rutter WJ, Naylor SL. Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse Somatic Cell and Molecular Genetics. 10: 377-383. PMID 6589791 DOI: 10.1007/Bf01535633 |
0.572 |
|
| 1984 |
Honey NK, Sakaguchi AY, Quinto C, MacDonald RJ, Bell GI, Craik C, Rutter WJ, Naylor SL. Chromosomal assignments of human genes for serine proteases trypsin, chymotrypsin B, and elastase Somatic Cell and Molecular Genetics. 10: 369-376. PMID 6589790 DOI: 10.1007/Bf01535632 |
0.579 |
|
| 1984 |
Bell GI, Quinto C, Quiroga M, Valenzuela P, Craik CS, Rutter WJ. Isolation and sequence of a rat chymotrypsin B gene. Journal of Biological Chemistry. 259: 14265-14270. DOI: 10.1016/s0021-9258(18)89887-8 |
0.368 |
|
| 1983 |
Craik CS, Rutter WJ, Fletterick R. Splice junctions: Association with variation in protein structure Science. 220: 1125-1129. PMID 6344214 DOI: 10.1126/Science.6344214 |
0.529 |
|
| 1982 |
Craik CS, Sprang S, Fletterick R, Rutter WJ. Intron-exon splice junctions map at protein surfaces. Nature. 299: 180-2. PMID 7110339 DOI: 10.1038/299180A0 |
0.528 |
|
| 1981 |
Craik CS, Buchman SR, Beychok S. O2 binding properties of the product of the central exon of beta-globin gene. Nature. 291: 87-90. PMID 7231528 DOI: 10.1038/291087A0 |
0.629 |
|
| 1980 |
Craik CS, Buchman SR, Beychok S. Characterization of globin domains: heme binding to the central exon product. Proceedings of the National Academy of Sciences of the United States of America. 77: 1384-8. PMID 6929492 DOI: 10.1073/Pnas.77.3.1384 |
0.644 |
|
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