Yoshiki Sasai - Publications

Affiliations: 
RIKEN Kobe, Kōbe-shi, Hyōgo-ken, Japan 
Area:
Developmental Neurobiology

147 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kuwahara A, Yamasaki S, Mandai M, Watari K, Matsushita K, Fujiwara M, Hori Y, Hiramine Y, Nukaya D, Iwata M, Kishino A, Takahashi M, Sasai Y, Kimura T. Publisher Correction: Preconditioning the Initial State of Feeder-free Human Pluripotent Stem Cells Promotes Self-formation of Three-dimensional Retinal Tissue. Scientific Reports. 10: 2237. PMID 32024912 DOI: 10.1038/S41598-020-58892-W  0.377
2019 Kuwahara A, Yamasaki S, Mandai M, Watari K, Matsushita K, Fujiwara M, Hori Y, Hiramine Y, Nukaya D, Iwata M, Kishino A, Takahashi M, Sasai Y, Kimura T. Preconditioning the Initial State of Feeder-free Human Pluripotent Stem Cells Promotes Self-formation of Three-dimensional Retinal Tissue. Scientific Reports. 9: 18936. PMID 31831759 DOI: 10.1038/S41598-019-55130-W  0.421
2018 Okuda S, Takata N, Hasegawa Y, Kawada M, Inoue Y, Adachi T, Sasai Y, Eiraku M. Strain-triggered mechanical feedback in self-organizing optic-cup morphogenesis. Science Advances. 4. PMID 30474058 DOI: 10.1126/Sciadv.Aau1354  0.706
2017 Takata N, Abbey D, Fiore L, Acosta S, Feng R, Gil HJ, Lavado A, Geng X, Interiano A, Neale G, Eiraku M, Sasai Y, Oliver G. An Eye Organoid Approach Identifies Six3 Suppression of R-spondin 2 as a Critical Step in Mouse Neuroretina Differentiation. Cell Reports. 21: 1534-1549. PMID 29117559 DOI: 10.1016/j.celrep.2017.10.041  0.703
2017 Takata N, Sakakura E, Eiraku M, Kasukawa T, Sasai Y. Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism. Nature Communications. 8: 1339. PMID 29109536 DOI: 10.1038/s41467-017-01105-2  0.394
2017 Ohgushi M, Minaguchi M, Eiraku M, Sasai Y. A RHO Small GTPase Regulator ABR Secures Mitotic Fidelity in Human Embryonic Stem Cells. Stem Cell Reports. PMID 28579391 DOI: 10.1016/j.stemcr.2017.05.003  0.447
2017 Shiraishi A, Muguruma K, Sasai Y. Generation of thalamic neurons from mouse embryonic stem cells. Development (Cambridge, England). PMID 28219951 DOI: 10.1242/dev.144071  0.415
2016 Ishida Y, Kawakami H, Kitajima H, Nishiyama A, Sasai Y, Inoue H, Muguruma K. Vulnerability of Purkinje Cells Generated from Spinocerebellar Ataxia Type 6 Patient-Derived iPSCs. Cell Reports. 17: 1482-1490. PMID 27806289 DOI: 10.1016/j.celrep.2016.10.026  0.377
2016 Hasegawa Y, Takata N, Okuda S, Kawada M, Eiraku M, Sasai Y. Emergence of dorsal-ventral polarity in ES cell-derived retinal tissue. Development (Cambridge, England). PMID 27633992 DOI: 10.1242/dev.134601  0.744
2016 Takata N, Sakakura E, Sasai Y. IGF-2/IGF-1R signaling has distinct effects on Sox1, Irx3, and Six3 expressions during ES cell derived-neuroectoderm development in vitro. In Vitro Cellular & Developmental Biology. Animal. PMID 26956358 DOI: 10.1007/s11626-016-0012-6  0.43
2016 Takata N, Sakakura E, Kasukawa T, Sakuma T, Yamamoto T, Sasai Y. Establishment of functional genomics pipeline in epiblast-like tissue by combining transcriptomic analysis and gene knock-down/-in/-out using RNAi and CRISPR/Cas9. Human Gene Therapy. PMID 26839115 DOI: 10.1089/hum.2015.148  0.423
2016 Ozone C, Suga H, Eiraku M, Kadoshima T, Yonemura S, Takata N, Oiso Y, Tsuji T, Sasai Y. Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells. Nature Communications. 7: 10351. PMID 26762480 DOI: 10.1038/ncomms10351  0.409
2015 Shirai H, Mandai M, Matsushita K, Kuwahara A, Yonemura S, Nakano T, Assawachananont J, Kimura T, Saito K, Terasaki H, Eiraku M, Sasai Y, Takahashi M. Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration. Proceedings of the National Academy of Sciences of the United States of America. PMID 26699487 DOI: 10.1073/Pnas.1512590113  0.355
2015 Sakaguchi H, Kadoshima T, Soen M, Narii N, Ishida Y, Ohgushi M, Takahashi J, Eiraku M, Sasai Y. Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue. Nature Communications. 6: 8896. PMID 26573335 DOI: 10.1038/Ncomms9896  0.428
2015 Takata N, Sakakura E, Sasai Y. Activation of Wnt/ß-catenin signaling in ESC promotes rostral forebrain differentiation in vitro. In Vitro Cellular & Developmental Biology. Animal. PMID 26563247 DOI: 10.1007/s11626-015-9975-y  0.429
2015 Okuda S, Inoue Y, Eiraku M, Adachi T, Sasai Y. Modeling cell apoptosis for simulating three-dimensional multicellular morphogenesis based on a reversible network reconnection framework. Biomechanics and Modeling in Mechanobiology. PMID 26361766 DOI: 10.1007/s10237-015-0724-7  0.73
2015 Ohgushi M, Minaguchi M, Sasai Y. Rho-Signaling-Directed YAP/TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem Cells. Cell Stem Cell. 17: 448-61. PMID 26321201 DOI: 10.1016/j.stem.2015.07.009  0.43
2015 Andrabi M, Kuraku S, Takata N, Sasai Y, Love NR. Comparative, transcriptome analysis of self-organizing optic tissues. Scientific Data. 2: 150030. PMID 26110066 DOI: 10.1038/Sdata.2015.30  0.393
2015 Kuwahara A, Ozone C, Nakano T, Saito K, Eiraku M, Sasai Y. Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue. Nature Communications. 6: 6286. PMID 25695148 DOI: 10.1038/ncomms7286  0.455
2015 Merkle FT, Maroof A, Wataya T, Sasai Y, Studer L, Eggan K, Schier AF. Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells. Development (Cambridge, England). 142: 633-43. PMID 25670790 DOI: 10.1242/Dev.117978  0.4
2015 Muguruma K, Nishiyama A, Kawakami H, Hashimoto K, Sasai Y. Self-organization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells. Cell Reports. 10: 537-50. PMID 25640179 DOI: 10.1016/j.celrep.2014.12.051  0.446
2015 Okuda S, Inoue Y, Eiraku M, Adachi T, Sasai Y. Vertex dynamics simulations of viscosity-dependent deformation during tissue morphogenesis. Biomechanics and Modeling in Mechanobiology. 14: 413-25. PMID 25227116 DOI: 10.1007/s10237-014-0613-5  0.681
2014 Obokata H, Wakayama T, Sasai Y, Kojima K, Vacanti MP, Niwa H, Yamato M, Vacanti CA. Retraction: Stimulus-triggered fate conversion of somatic cells into pluripotency. Nature. 511: 112. PMID 24990753 DOI: 10.1038/nature13598  0.478
2014 Obokata H, Sasai Y, Niwa H, Kadota M, Andrabi M, Takata N, Tokoro M, Terashita Y, Yonemura S, Vacanti CA, Wakayama T. Retraction: Bidirectional developmental potential in reprogrammed cells with acquired pluripotency. Nature. 511: 112. PMID 24990752 DOI: 10.1038/nature13599  0.499
2014 Assawachananont J, Mandai M, Okamoto S, Yamada C, Eiraku M, Yonemura S, Sasai Y, Takahashi M. Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice. Stem Cell Reports. 2: 662-74. PMID 24936453 DOI: 10.1016/J.Stemcr.2014.03.011  0.378
2014 Numata R, Okumura N, Nakahara M, Ueno M, Kinoshita S, Kanematsu D, Kanemura Y, Sasai Y, Koizumi N. Cultivation of corneal endothelial cells on a pericellular matrix prepared from human decidua-derived mesenchymal cells. Plos One. 9: e88169. PMID 24505413 DOI: 10.1371/journal.pone.0088169  0.386
2014 Obokata H, Sasai Y, Niwa H, Kadota M, Andrabi M, Takata N, Tokoro M, Terashita Y, Yonemura S, Vacanti CA, Wakayama T. Bidirectional developmental potential in reprogrammed cells with acquired pluripotency. Nature. 505: 676-80. PMID 24476891 DOI: 10.1038/nature12969  0.502
2014 Obokata H, Wakayama T, Sasai Y, Kojima K, Vacanti MP, Niwa H, Yamato M, Vacanti CA. Stimulus-triggered fate conversion of somatic cells into pluripotency. Nature. 505: 641-7. PMID 24476887 DOI: 10.1038/nature12968  0.459
2014 Ono K, Kita T, Sato S, O'Neill P, Mak SS, Paschaki M, Ito M, Gotoh N, Kawakami K, Sasai Y, Ladher RK. FGFR1-Frs2/3 signalling maintains sensory progenitors during inner ear hair cell formation. Plos Genetics. 10: e1004118. PMID 24465223 DOI: 10.1371/journal.pgen.1004118  0.325
2014 Okuda S, Eiraku M, Sasai Y. 2P137 3D vertex model for revealing mechanics in multicellular morphogenesis(09. Development & Differentiation,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014)) Seibutsu Butsuri. 54: S217. DOI: 10.2142/biophys.54.S217_5  0.68
2014 Niwa H, Obokata H, Sasai Y. Essential technical tips for STAP cell conversion culture from somatic cells Protocol Exchange. DOI: 10.1038/Protex.2014.008  0.405
2014 Takata N, Sakakura E, Kasukawa T, Eiraku M, Sasai Y. GP2-7: The IGF/IGFR pathway regulates axial patterning during early neural development in mammal Growth Hormone & Igf Research. 24: S29. DOI: 10.1016/S1096-6374(14)50074-3  0.334
2013 Kadoshima T, Sakaguchi H, Nakano T, Soen M, Ando S, Eiraku M, Sasai Y. Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex. Proceedings of the National Academy of Sciences of the United States of America. 110: 20284-9. PMID 24277810 DOI: 10.1073/pnas.1315710110  0.392
2013 Inomata H, Shibata T, Haraguchi T, Sasai Y. Scaling of dorsal-ventral patterning by embryo size-dependent degradation of Spemann's organizer signals. Cell. 153: 1296-311. PMID 23746842 DOI: 10.1016/J.Cell.2013.05.004  0.338
2013 Okuda S, Inoue Y, Eiraku M, Sasai Y, Adachi T. Apical contractility in growing epithelium supports robust maintenance of smooth curvatures against cell-division-induced mechanical disturbance. Journal of Biomechanics. 46: 1705-13. PMID 23676291 DOI: 10.1016/j.jbiomech.2013.03.035  0.703
2013 Chen YJ, Vogt D, Wang Y, Visel A, Silberberg SN, Nicholas CR, Danjo T, Pollack JL, Pennacchio LA, Anderson S, Sasai Y, Baraban SC, Kriegstein AR, Alvarez-Buylla A, Rubenstein JL. Use of "MGE enhancers" for labeling and selection of embryonic stem cell-derived medial ganglionic eminence (MGE) progenitors and neurons. Plos One. 8: e61956. PMID 23658702 DOI: 10.1371/Journal.Pone.0061956  0.504
2013 Nicholas CR, Chen J, Tang Y, Southwell DG, Chalmers N, Vogt D, Arnold CM, Chen YJ, Stanley EG, Elefanty AG, Sasai Y, Alvarez-Buylla A, Rubenstein JL, Kriegstein AR. Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. Cell Stem Cell. 12: 573-86. PMID 23642366 DOI: 10.1016/J.Stem.2013.04.005  0.466
2013 Sasai Y. Next-generation regenerative medicine: organogenesis from stem cells in 3D culture. Cell Stem Cell. 12: 520-30. PMID 23642363 DOI: 10.1016/j.stem.2013.04.009  0.431
2013 Fukusumi H, Shofuda T, Kanematsu D, Yamamoto A, Suemizu H, Nakamura M, Yamasaki M, Ohgushi M, Sasai Y, Kanemura Y. Feeder-free generation and long-term culture of human induced pluripotent stem cells using pericellular matrix of decidua derived mesenchymal cells. Plos One. 8: e55226. PMID 23383118 DOI: 10.1371/Journal.Pone.0055226  0.48
2013 Sasai Y. Cytosystems dynamics in self-organization of tissue architecture. Nature. 493: 318-26. PMID 23325214 DOI: 10.1038/nature11859  0.335
2013 Okuda S, Inoue Y, Eiraku M, Sasai Y, Adachi T. Modeling cell proliferation for simulating three-dimensional tissue morphogenesis based on a reversible network reconnection framework. Biomechanics and Modeling in Mechanobiology. 12: 987-96. PMID 23196700 DOI: 10.1007/s10237-012-0458-8  0.738
2013 Okuda S, Inoue Y, Eiraku M, Sasai Y, Adachi T. Reversible network reconnection model for simulating large deformation in dynamic tissue morphogenesis. Biomechanics and Modeling in Mechanobiology. 12: 627-44. PMID 22941051 DOI: 10.1007/s10237-012-0430-7  0.699
2013 OKUDA S, INOUE Y, EIRAKU M, SASAI Y, ADACHI T. S021011 Reversible Network Reconnection Simulation of Effects of Apical Contractility on Curvatures of Growing Epithelia The Proceedings of Mechanical Engineering Congress, Japan. 2013: _S021011-1-_S021011-. DOI: 10.1299/jsmemecj.2013._S021011-1  0.629
2012 Nasu M, Takata N, Danjo T, Sakaguchi H, Kadoshima T, Futaki S, Sekiguchi K, Eiraku M, Sasai Y. Robust formation and maintenance of continuous stratified cortical neuroepithelium by laminin-containing matrix in mouse ES cell culture. Plos One. 7: e53024. PMID 23300850 DOI: 10.1371/journal.pone.0053024  0.347
2012 Sasai Y, Eiraku M, Suga H. In vitro organogenesis in three dimensions: self-organising stem cells. Development (Cambridge, England). 139: 4111-21. PMID 23093423 DOI: 10.1242/dev.079590  0.408
2012 Nakano T, Ando S, Takata N, Kawada M, Muguruma K, Sekiguchi K, Saito K, Yonemura S, Eiraku M, Sasai Y. Self-formation of optic cups and storable stratified neural retina from human ESCs. Cell Stem Cell. 10: 771-85. PMID 22704518 DOI: 10.1016/j.stem.2012.05.009  0.391
2012 Eiraku M, Sasai Y. Self-formation of layered neural structures in three-dimensional culture of ES cells. Current Opinion in Neurobiology. 22: 768-77. PMID 22405989 DOI: 10.1016/j.conb.2012.02.005  0.473
2012 Muguruma K, Sasai Y. In vitro recapitulation of neural development using embryonic stem cells: from neurogenesis to histogenesis. Development, Growth & Differentiation. 54: 349-57. PMID 22404483 DOI: 10.1111/j.1440-169X.2012.01329.x  0.505
2012 Doi D, Morizane A, Kikuchi T, Onoe H, Hayashi T, Kawasaki T, Motono M, Sasai Y, Saiki H, Gomi M, Yoshikawa T, Hayashi H, Shinoyama M, Refaat MM, Suemori H, et al. Prolonged maturation culture favors a reduction in the tumorigenicity and the dopaminergic function of human ESC-derived neural cells in a primate model of Parkinson's disease. Stem Cells (Dayton, Ohio). 30: 935-45. PMID 22328536 DOI: 10.1002/Stem.1060  0.461
2012 Eiraku M, Sasai Y. Mouse embryonic stem cell culture for generation of three-dimensional retinal and cortical tissues. Nature Protocols. 7: 69-79. PMID 22179593 DOI: 10.1038/nprot.2011.429  0.427
2012 Eiraku M, Adachi T, Sasai Y. Relaxation-expansion model for self-driven retinal morphogenesis: a hypothesis from the perspective of biosystems dynamics at the multi-cellular level. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 34: 17-25. PMID 22052700 DOI: 10.1002/bies.201100070  0.37
2012 Okuda S, Inoue Y, Eiraku M, Sasai Y, Adachi T. 1PT219 Simulations of large deformation during tissue morphogenesis using reversible network reconnection model(The 50th Annual Meeting of the Biophysical Society of Japan) Seibutsu Butsuri. 52: S105. DOI: 10.2142/biophys.52.S105_5  0.662
2011 Suga H, Kadoshima T, Minaguchi M, Ohgushi M, Soen M, Nakano T, Takata N, Wataya T, Muguruma K, Miyoshi H, Yonemura S, Oiso Y, Sasai Y. Self-formation of functional adenohypophysis in three-dimensional culture. Nature. 480: 57-62. PMID 22080957 DOI: 10.1038/nature10637  0.445
2011 Eiraku M, Takata N, Ishibashi H, Kawada M, Sakakura E, Okuda S, Sekiguchi K, Adachi T, Sasai Y. Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature. 472: 51-6. PMID 21475194 DOI: 10.1038/nature09941  0.745
2011 Ohgushi M, Sasai Y. Lonely death dance of human pluripotent stem cells: ROCKing between metastable cell states. Trends in Cell Biology. 21: 274-82. PMID 21444207 DOI: 10.1016/j.tcb.2011.02.004  0.43
2011 Kamiya D, Banno S, Sasai N, Ohgushi M, Inomata H, Watanabe K, Kawada M, Yakura R, Kiyonari H, Nakao K, Jakt LM, Nishikawa S, Sasai Y. Intrinsic transition of embryonic stem-cell differentiation into neural progenitors. Nature. 470: 503-9. PMID 21326203 DOI: 10.1038/nature09726  0.542
2011 Danjo T, Eiraku M, Muguruma K, Watanabe K, Kawada M, Yanagawa Y, Rubenstein JL, Sasai Y. Subregional specification of embryonic stem cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 1919-33. PMID 21289201 DOI: 10.1523/Jneurosci.5128-10.2011  0.507
2011 OKUDA S, INOUE Y, EIRAKU M, SASAI Y, ADACHI T. J025021 Mathematical Insight into Modeling Morphological Development of Sheet-Like Multicellular Tissue The Proceedings of Mechanical Engineering Congress, Japan. 2011: _J025021-1-_J025021-. DOI: 10.1299/jsmemecj.2011._J025021-1  0.656
2011 Danjo T, Eiraku M, Muguruma K, Watanabe K, Kawada M, Yanagawa Y, Rubenstein JL, Sasai Y. Subregional specification of ES cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals Neuroscience Research. 71: e126. DOI: 10.1016/J.Neures.2011.07.538  0.396
2010 Aramaki T, Sasai N, Yakura R, Sasai Y. Jiraiya attenuates BMP signaling by interfering with type II BMP receptors in neuroectodermal patterning. Developmental Cell. 19: 547-61. PMID 20951346 DOI: 10.1016/j.devcel.2010.09.001  0.403
2010 Muguruma K, Nishiyama A, Ono Y, Miyawaki H, Mizuhara E, Hori S, Kakizuka A, Obata K, Yanagawa Y, Hirano T, Sasai Y. Ontogeny-recapitulating generation and tissue integration of ES cell-derived Purkinje cells. Nature Neuroscience. 13: 1171-80. PMID 20835252 DOI: 10.1038/Nn.2638  0.652
2010 Takai A, Inomata H, Arakawa A, Yakura R, Matsuo-Takasaki M, Sasai Y. Anterior neural development requires Del1, a matrix-associated protein that attenuates canonical Wnt signaling via the Ror2 pathway. Development (Cambridge, England). 137: 3293-302. PMID 20823067 DOI: 10.1242/dev.051136  0.409
2010 Ohgushi M, Matsumura M, Eiraku M, Murakami K, Aramaki T, Nishiyama A, Muguruma K, Nakano T, Suga H, Ueno M, Ishizaki T, Suemori H, Narumiya S, Niwa H, Sasai Y. Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells. Cell Stem Cell. 7: 225-39. PMID 20682448 DOI: 10.1016/j.stem.2010.06.018  0.409
2010 Mizuhara E, Minaki Y, Nakatani T, Kumai M, Inoue T, Muguruma K, Sasai Y, Ono Y. Purkinje cells originate from cerebellar ventricular zone progenitors positive for Neph3 and E-cadherin. Developmental Biology. 338: 202-14. PMID 20004188 DOI: 10.1016/j.ydbio.2009.11.032  0.431
2010 Ikeya M, Fukushima K, Kawada M, Onishi S, Furuta Y, Yonemura S, Kitamura T, Nosaka T, Sasai Y. Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors. Developmental Biology. 337: 405-14. PMID 19914233 DOI: 10.1016/J.Ydbio.2009.11.013  0.408
2010 Muguruma K, Nishiyama A, Ono Y, Miyawaki H, Mizuhara E, Yanagawa Y, Hirano T, Sasai Y. Steered differentiation and prospective selection of cerebellar Purkinje cells in the ES cell culture system Neuroscience Research. 68: e243. DOI: 10.1016/J.Neures.2010.07.1078  0.64
2009 Osakada F, Jin ZB, Hirami Y, Ikeda H, Danjyo T, Watanabe K, Sasai Y, Takahashi M. In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. Journal of Cell Science. 122: 3169-79. PMID 19671662 DOI: 10.1242/Jcs.050393  0.716
2009 Osakada F, Ikeda H, Sasai Y, Takahashi M. Stepwise differentiation of pluripotent stem cells into retinal cells. Nature Protocols. 4: 811-24. PMID 19444239 DOI: 10.1038/Nprot.2009.51  0.722
2009 Nagase T, Ueno M, Matsumura M, Muguruma K, Ohgushi M, Kondo N, Kanematsu D, Kanemura Y, Sasai Y. Pericellular matrix of decidua-derived mesenchymal cells: a potent human-derived substrate for the maintenance culture of human ES cells. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 238: 1118-30. PMID 19384957 DOI: 10.1002/dvdy.21944  0.421
2009 Eiraku M, Sasai Y. Self-organized formation of cortical neural tissue from embryonic stem cells Neuroscience Research. 65: S23-S24. DOI: 10.1016/j.neures.2009.09.1621  0.43
2008 Eiraku M, Watanabe K, Matsuo-Takasaki M, Kawada M, Yonemura S, Matsumura M, Wataya T, Nishiyama A, Muguruma K, Sasai Y. Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals. Cell Stem Cell. 3: 519-32. PMID 18983967 DOI: 10.1016/j.stem.2008.09.002  0.397
2008 Wataya T, Muguruma K, Sasai Y. [Human pluripotent stem cell and neural differentiation]. Brain and Nerve = Shinkei Kenkyū No Shinpo. 60: 1165-72. PMID 18975604  0.386
2008 Inomata H, Haraguchi T, Sasai Y. Robust stability of the embryonic axial pattern requires a secreted scaffold for chordin degradation. Cell. 134: 854-65. PMID 18775317 DOI: 10.1016/j.cell.2008.07.008  0.387
2008 Wataya T, Ando S, Muguruma K, Ikeda H, Watanabe K, Eiraku M, Kawada M, Takahashi J, Hashimoto N, Sasai Y. Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation. Proceedings of the National Academy of Sciences of the United States of America. 105: 11796-801. PMID 18697938 DOI: 10.1073/Pnas.0803078105  0.523
2008 Sasai N, Yakura R, Kamiya D, Nakazawa Y, Sasai Y. Ectodermal factor restricts mesoderm differentiation by inhibiting p53. Cell. 133: 878-90. PMID 18510931 DOI: 10.1016/j.cell.2008.03.035  0.395
2008 Sasai Y, Ogushi M, Nagase T, Ando S. Bridging the gap from frog research to human therapy: a tale of neural differentiation in Xenopus animal caps and human pluripotent cells. Development, Growth & Differentiation. 50: S47-55. PMID 18494707 DOI: 10.1111/j.1440-169X.2008.01010.x  0.404
2008 Osakada F, Ikeda H, Mandai M, Wataya T, Watanabe K, Yoshimura N, Akaike A, Akaike A, Sasai Y, Takahashi M. Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells. Nature Biotechnology. 26: 215-24. PMID 18246062 DOI: 10.1038/Nbt1384  0.757
2008 Hayashi H, Morizane A, Koyanagi M, Ono Y, Sasai Y, Hashimoto N, Takahashi J. Meningeal cells induce dopaminergic neurons from embryonic stem cells. The European Journal of Neuroscience. 27: 261-8. PMID 18215228 DOI: 10.1111/J.1460-9568.2008.06027.X  0.46
2008 Osakada F, Sasai Y, Takahashi M. Control of neural differentiation from pluripotent stem cells Inflammation and Regeneration. 28: 166-173. DOI: 10.2492/Inflammregen.28.166  0.747
2008 Osakada F, Ikeda H, Mandai M, Wataya T, Watanabe K, Yoshimura N, Akaike A, Sasai Y, Takahashi M. Corrigendum: Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells (Nature Biotechnology (2008) 26, (215-224)) Nature Biotechnology. 26: 352. DOI: 10.1038/Nbt0308-352B  0.712
2007 Watanabe K, Ueno M, Kamiya D, Nishiyama A, Matsumura M, Wataya T, Takahashi JB, Nishikawa S, Nishikawa S, Muguruma K, Sasai Y. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nature Biotechnology. 25: 681-6. PMID 17529971 DOI: 10.1038/nbt1310  0.46
2007 Arakawa A, Matsuo-Takasaki M, Takai A, Inomata H, Matsumura M, Ikeya M, Takahashi K, Miyachi Y, Sasai N, Sasai Y. The secreted EGF-Discoidin factor xDel1 is essential for dorsal development of the Xenopus embryo. Developmental Biology. 306: 160-9. PMID 17433289 DOI: 10.1016/j.ydbio.2007.03.008  0.447
2007 Onai T, Matsuo-Takasaki M, Inomata H, Aramaki T, Matsumura M, Yakura R, Sasai N, Sasai Y. XTsh3 is an essential enhancing factor of canonical Wnt signaling in Xenopus axial determination. The Embo Journal. 26: 2350-60. PMID 17431396 DOI: 10.1038/sj.emboj.7601684  0.358
2007 Sasai Y. A matter of some importins: nuclear transport factors in ES cell maintenance and differentiation. Developmental Cell. 12: 172-4. PMID 17276333 DOI: 10.1016/j.devcel.2007.01.006  0.416
2007 Maki N, Takechi K, Sano S, Tarui H, Sasai Y, Agata K. Rapid accumulation of nucleostemin in nucleolus during newt regeneration. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 236: 941-50. PMID 17133523 DOI: 10.1002/Dvdy.21027  0.464
2007 Sasai Y. Regulatory mechanisms of neural differentiation from pluripotent cells Neuroscience Research. 58: S19. DOI: 10.1016/j.neures.2007.06.110  0.485
2006 Ikeya M, Kawada M, Kiyonari H, Sasai N, Nakao K, Furuta Y, Sasai Y. Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis. Development (Cambridge, England). 133: 4463-73. PMID 17035289 DOI: 10.1242/Dev.02647  0.372
2006 Ueno M, Matsumura M, Watanabe K, Nakamura T, Osakada F, Takahashi M, Kawasaki H, Kinoshita S, Sasai Y. Neural conversion of ES cells by an inductive activity on human amniotic membrane matrix. Proceedings of the National Academy of Sciences of the United States of America. 103: 9554-9. PMID 16766664 DOI: 10.1073/Pnas.0600104103  0.761
2006 Yamazoe H, Kobori M, Murakami Y, Yano K, Satoh M, Mizuseki K, Sasai Y, Iwata H. One-step induction of neurons from mouse embryonic stem cells in serum-free media containing vitamin B12 and heparin. Cell Transplantation. 15: 135-45. PMID 16719047 DOI: 10.3727/000000006783982061  0.789
2006 Brederlau A, Correia AS, Anisimov SV, Elmi M, Paul G, Roybon L, Morizane A, Bergquist F, Riebe I, Nannmark U, Carta M, Hanse E, Takahashi J, Sasai Y, Funa K, et al. Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: effect of in vitro differentiation on graft survival and teratoma formation. Stem Cells (Dayton, Ohio). 24: 1433-40. PMID 16556709 DOI: 10.1634/Stemcells.2005-0393  0.402
2006 Morizane A, Takahashi J, Shinoyama M, Ideguchi M, Takagi Y, Fukuda H, Koyanagi M, Sasai Y, Hashimoto N. Generation of graftable dopaminergic neuron progenitors from mouse ES cells by a combination of coculture and neurosphere methods. Journal of Neuroscience Research. 83: 1015-27. PMID 16493682 DOI: 10.1002/Jnr.20799  0.434
2006 Sakuragi M, Sasai N, Ikeya M, Kawada M, Onai T, Katahira T, Nakamura H, Sasai Y. Functional analysis of chick ONT1 reveals distinguishable activities among olfactomedin-related signaling factors. Mechanisms of Development. 123: 114-23. PMID 16412616 DOI: 10.1016/j.mod.2005.11.005  0.448
2006 Su HL, Muguruma K, Matsuo-Takasaki M, Kengaku M, Watanabe K, Sasai Y. Generation of cerebellar neuron precursors from embryonic stem cells. Developmental Biology. 290: 287-96. PMID 16406324 DOI: 10.1016/j.ydbio.2005.11.010  0.504
2006 Fukuda H, Takahashi J, Watanabe K, Hayashi H, Morizane A, Koyanagi M, Sasai Y, Hashimoto N. Fluorescence-activated cell sorting-based purification of embryonic stem cell-derived neural precursors averts tumor formation after transplantation. Stem Cells (Dayton, Ohio). 24: 763-71. PMID 16223855 DOI: 10.1634/Stemcells.2005-0137  0.441
2005 Ikeya M, Kawada M, Nakazawa Y, Sakuragi M, Sasai N, Ueno M, Kiyonari H, Nakao K, Sasai Y. Gene disruption/knock-in analysis of mONT3: vector construction by employing both in vivo and in vitro recombinations. The International Journal of Developmental Biology. 49: 807-23. PMID 16172977 DOI: 10.1387/ijdb.051975mi  0.328
2005 Sasai Y. Directed differentiation of neural and sensory tissues from embryonic stem cells in vitro. Ernst Schering Research Foundation Workshop. 101-9. PMID 16080289  0.471
2005 Matsuo-Takasaki M, Matsumura M, Sasai Y. An essential role of Xenopus Foxi1a for ventral specification of the cephalic ectoderm during gastrulation. Development (Cambridge, England). 132: 3885-94. PMID 16079156 DOI: 10.1242/dev.01959  0.43
2005 Ikeda H, Osakada F, Watanabe K, Mizuseki K, Haraguchi T, Miyoshi H, Kamiya D, Honda Y, Sasai N, Yoshimura N, Takahashi M, Sasai Y. Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 102: 11331-6. PMID 16076961 DOI: 10.1073/Pnas.0500010102  0.822
2005 Watanabe K, Sasai Y. [In vitro differentiation of telencephalic precursors from ES cells]. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 50: 711-6. PMID 15926504  0.382
2005 Sasai Y. Developmental biology: a blank canvas no more. Nature. 435: 433-4. PMID 15917790 DOI: 10.1038/435433a  0.41
2005 Yamazoe H, Murakami Y, Mizuseki K, Sasai Y, Iwata H. Collection of neural inducing factors from PA6 cells using heparin solution and their immobilization on plastic culture dishes for the induction of neurons from embryonic stem cells. Biomaterials. 26: 5746-54. PMID 15878380 DOI: 10.1016/J.Biomaterials.2005.02.021  0.806
2005 Sato T, Sasai N, Sasai Y. Neural crest determination by co-activation of Pax3 and Zic1 genes in Xenopus ectoderm. Development (Cambridge, England). 132: 2355-63. PMID 15843410 DOI: 10.1242/dev.01823  0.445
2005 Watanabe K, Kamiya D, Nishiyama A, Katayama T, Nozaki S, Kawasaki H, Watanabe Y, Mizuseki K, Sasai Y. Directed differentiation of telencephalic precursors from embryonic stem cells. Nature Neuroscience. 8: 288-96. PMID 15696161 DOI: 10.1038/Nn1402  0.829
2005 Takagi Y, Takahashi J, Saiki H, Morizane A, Hayashi T, Kishi Y, Fukuda H, Okamoto Y, Koyanagi M, Ideguchi M, Hayashi H, Imazato T, Kawasaki H, Suemori H, Omachi S, ... ... Sasai Y, et al. Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. The Journal of Clinical Investigation. 115: 102-9. PMID 15630449 DOI: 10.1172/Jci21137  0.581
2005 Irioka T, Watanabe K, Mizusawa H, Mizuseki K, Sasai Y. Distinct effects of caudalizing factors on regional specification of embryonic stem cell-derived neural precursors. Brain Research. Developmental Brain Research. 154: 63-70. PMID 15617756 DOI: 10.1016/J.Devbrainres.2004.10.004  0.791
2004 Sasai N, Nakazawa Y, Haraguchi T, Sasai Y. The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movements. Nature Cell Biology. 6: 741-8. PMID 15258592 DOI: 10.1038/ncb1158  0.394
2004 Onai T, Sasai N, Matsui M, Sasai Y. Xenopus XsalF: anterior neuroectodermal specification by attenuating cellular responsiveness to Wnt signaling. Developmental Cell. 7: 95-106. PMID 15239957 DOI: 10.1016/j.devcel.2004.06.004  0.373
2004 Sakamoto T, Nakagawa T, Endo T, Kim TS, Iguchi F, Naito Y, Sasai Y, Ito J. Fates of mouse embryonic stem cells transplanted into the inner ears of adult mice and embryonic chickens. Acta Oto-Laryngologica. Supplementum. 48-52. PMID 15078078 DOI: 10.1080/03655230310016825  0.459
2004 Haruta M, Sasai Y, Kawasaki H, Amemiya K, Ooto S, Kitada M, Suemori H, Nakatsuji N, Ide C, Honda Y, Takahashi M. In vitro and in vivo characterization of pigment epithelial cells differentiated from primate embryonic stem cells. Investigative Ophthalmology & Visual Science. 45: 1020-5. PMID 14985325 DOI: 10.1167/Iovs.03-1034  0.605
2003 Tada M, Morizane A, Kimura H, Kawasaki H, Ainscough JF, Sasai Y, Nakatsuji N, Tada T. Pluripotency of reprogrammed somatic genomes in embryonic stem hybrid cells. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 227: 504-10. PMID 12889059 DOI: 10.1002/Dvdy.10337  0.606
2003 Ooto S, Haruta M, Honda Y, Kawasaki H, Sasai Y, Takahashi M. Induction of the differentiation of lentoids from primate embryonic stem cells. Investigative Ophthalmology & Visual Science. 44: 2689-93. PMID 12766074 DOI: 10.1167/Iovs.02-1168  0.637
2003 Mizuseki K, Sakamoto T, Watanabe K, Muguruma K, Ikeya M, Nishiyama A, Arakawa A, Suemori H, Nakatsuji N, Kawasaki H, Murakami F, Sasai Y. Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 5828-33. PMID 12724518 DOI: 10.1073/Pnas.1037282100  0.839
2002 Sasai Y. Generation of dopaminergic neurons from embryonic stem cells. Journal of Neurology. 249: II41-4. PMID 12375063 DOI: 10.1007/s00415-002-1208-0  0.482
2002 Morizane A, Takahashi J, Takagi Y, Sasai Y, Hashimoto N. Optimal conditions for in vivo induction of dopaminergic neurons from embryonic stem cells through stromal cell-derived inducing activity. Journal of Neuroscience Research. 69: 934-9. PMID 12205686 DOI: 10.1002/Jnr.10363  0.425
2002 Tsuda H, Sasai N, Matsuo-Takasaki M, Sakuragi M, Murakami Y, Sasai Y. Dorsalization of the neural tube by Xenopus tiarin, a novel patterning factor secreted by the flanking nonneural head ectoderm. Neuron. 33: 515-28. PMID 11856527 DOI: 10.1016/S0896-6273(02)00590-1  0.442
2002 Kawasaki H, Suemori H, Mizuseki K, Watanabe K, Urano F, Ichinose H, Haruta M, Takahashi M, Yoshikawa K, Nishikawa S, Nakatsuji N, Sasai Y. Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity. Proceedings of the National Academy of Sciences of the United States of America. 99: 1580-5. PMID 11818560 DOI: 10.1073/Pnas.032662199  0.823
2002 Kawasaki H, Mizuseki K, Sasai Y. Selective neural induction from ES cells by stromal cell-derived inducing activity and its potential therapeutic application in Parkinson's disease. Methods in Molecular Biology (Clifton, N.J.). 185: 217-27. PMID 11768991 DOI: 10.1385/1-59259-241-4:217  0.803
2001 Sasai N, Mizuseki K, Sasai Y. Requirement of FoxD3-class signaling for neural crest determination in Xenopus. Development (Cambridge, England). 128: 2525-36. PMID 11493569  0.782
2001 Sasai Y. Roles of Sox factors in neural determination: conserved signaling in evolution? The International Journal of Developmental Biology. 45: 321-6. PMID 11291862 DOI: 10.1387/Ijdb.11291862  0.44
2001 Sasai Y. Regulation of neural determination by evolutionarily conserved signals: anti-BMP factors and what next? Current Opinion in Neurobiology. 11: 22-6. PMID 11179868 DOI: 10.1016/S0959-4388(00)00169-0  0.377
2000 Kawasaki H, Mizuseki K, Nishikawa S, Kaneko S, Kuwana Y, Nakanishi S, Nishikawa SI, Sasai Y. Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. Neuron. 28: 31-40. PMID 11086981 DOI: 10.1016/S0896-6273(00)00083-0  0.816
2000 Matsui M, Mizuseki K, Nakatani J, Nakanishi S, Sasai Y. Xenopus kielin: A dorsalizing factor containing multiple chordin-type repeats secreted from the embryonic midline. Proceedings of the National Academy of Sciences of the United States of America. 97: 5291-6. PMID 10779551 DOI: 10.1073/Pnas.090020497  0.809
2000 Nakatani J, Mizuseki K, Tsuda H, Nakanishi S, Sasai Y. Xenopus Xenf: an early endodermal nuclear factor that is regulated in a pathway distinct from Sox17 and Mix-related gene pathways. Mechanisms of Development. 91: 81-9. PMID 10704833 DOI: 10.1016/S0925-4773(99)00274-9  0.79
2000 Kishi M, Mizuseki K, Sasai N, Yamazaki H, Shiota K, Nakanishi S, Sasai Y. Requirement of Sox2-mediated signaling for differentiation of early Xenopus neuroectoderm. Development (Cambridge, England). 127: 791-800. PMID 10648237  0.8
1998 Sasai Y. Identifying the missing links: genes that connect neural induction and primary neurogenesis in vertebrate embryos. Neuron. 21: 455-8. PMID 9768831 DOI: 10.1016/S0896-6273(00)80554-1  0.45
1998 Mizuseki K, Kishi M, Shiota K, Nakanishi S, Sasai Y. SoxD: an essential mediator of induction of anterior neural tissues in Xenopus embryos. Neuron. 21: 77-85. PMID 9697853 DOI: 10.1016/S0896-6273(00)80516-4  0.815
1998 Yamanaka Y, Mizuno T, Sasai Y, Kishi M, Takeda H, Kim CH, Hibi M, Hirano T. A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner. Genes & Development. 12: 2345-53. PMID 9694799 DOI: 10.1101/Gad.12.15.2345  0.385
1998 Mizuseki K, Kishi M, Matsui M, Nakanishi S, Sasai Y. Xenopus Zic-related-1 and Sox-2, two factors induced by chordin, have distinct activities in the initiation of neural induction. Development (Cambridge, England). 125: 579-87. PMID 9435279  0.777
1998 Sasai Y. The neural inducer chordin and its downstream genes Neuroscience Research. 31: S42. DOI: 10.1016/S0168-0102(98)81641-6  0.351
1997 Sasai Y, De Robertis EM. Ectodermal patterning in vertebrate embryos. Developmental Biology. 182: 5-20. PMID 9073437 DOI: 10.1006/dbio.1996.8445  0.616
1996 Sasai Y, Lu B, Piccolo S, De Robertis EM. Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps. The Embo Journal. 15: 4547-55. PMID 8887546 DOI: 10.1002/J.1460-2075.1996.Tb00832.X  0.732
1996 Bouwmeester T, Kim S, Sasai Y, Lu B, De Robertis EM. Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature. 382: 595-601. PMID 8757128 DOI: 10.1038/382595a0  0.578
1996 Holley SA, Neul JL, Attisano L, Wrana JL, Sasai Y, O'Connor MB, De Robertis EM, Ferguson EL. The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor. Cell. 86: 607-17. PMID 8752215 DOI: 10.1016/S0092-8674(00)80134-8  0.618
1996 Piccolo S, Sasai Y, Lu B, De Robertis EM. Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4. Cell. 86: 589-98. PMID 8752213 DOI: 10.1016/S0092-8674(00)80132-4  0.685
1996 De Robertis EM, Sasai Y. A common plan for dorsoventral patterning in Bilateria. Nature. 380: 37-40. PMID 8598900 DOI: 10.1038/380037a0  0.605
1996 Sasai Y, Lu B, Piccolo S, De Robertis EM. Endoderm induction by the organizer-secreted factors chordin and noggin in Xenopus animal caps. The Embo Journal. 15: 4547-4555. DOI: 10.1002/j.1460-2075.1996.tb00832.x  0.535
1995 Sasai Y, Lu B, Steinbeisser H, De Robertis EM. Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. Nature. 376: 333-6. PMID 7630399 DOI: 10.1038/376333a0  0.634
1995 Holley SA, Jackson PD, Sasai Y, Lu B, De Robertis EM, Hoffmann FM, Ferguson EL. A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin. Nature. 376: 249-53. PMID 7617035 DOI: 10.1038/376249a0  0.593
1995 Steinbeisser H, Fainsod A, Niehrs C, Sasai Y, De Robertis EM. The role of gsc and BMP-4 in dorsal-ventral patterning of the marginal zone in Xenopus: a loss-of-function study using antisense RNA. The Embo Journal. 14: 5230-43. PMID 7489713  0.537
1995 Sasai Y, Lu B, Steinbeisser H, De Robertis EM. Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. Nature. 377: 757. PMID 7477270 DOI: 10.1038/377757a0  0.529
1995 Steinbeisser H, Fainsod A, Niehrs C, Sasai Y, De Robertis EM. The role of gsc and BMP-4 in dorsal-ventral patterning of the marginal zone in Xenopus: a loss-of-function study using antisense RNA. The Embo Journal. 14: 5230-5243. DOI: 10.1002/j.1460-2075.1995.tb00208.x  0.751
1994 Sasai Y, Lu B, Steinbeisser H, Geissert D, Gont LK, De Robertis EM. Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes. Cell. 79: 779-90. PMID 8001117 DOI: 10.1016/0092-8674(94)90068-X  0.611
1994 Ishibashi M, Moriyoshi K, Sasai Y, Shiota K, Nakanishi S, Kageyama R. Persistent expression of helix-loop-helix factor HES-1 prevents mammalian neural differentiation in the central nervous system. The Embo Journal. 13: 1799-805. PMID 7909512 DOI: 10.1002/J.1460-2075.1994.Tb06448.X  0.473
1993 Ishibashi M, Sasai Y, Nakanishi S, Kageyama R. Molecular characterization of HES-2, a mammalian helix-loop-helix factor structurally related to Drosophila hairy and Enhancer of split. European Journal of Biochemistry / Febs. 215: 645-52. PMID 8354270 DOI: 10.1111/J.1432-1033.1993.Tb18075.X  0.636
1992 Sasai Y, Kageyama R, Tagawa Y, Shigemoto R, Nakanishi S. Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split. Genes & Development. 6: 2620-34. PMID 1340473 DOI: 10.1101/Gad.6.12B.2620  0.688
1990 Nakanishi S, Ohkubo H, Kakizuka A, Yokota Y, Shigemoto R, Sasai Y, Takumi T. Molecular characterization of mammalian tachykinin receptors and a possible epithelial potassium channel. Recent Progress in Hormone Research. 46: 59-83; discussion 83. PMID 2177908 DOI: 10.1016/B978-0-12-571146-3.50007-9  0.537
1989 Sasai Y, Nakanishi S. Molecular characterization of rat substance K receptor and its mRNAs. Biochemical and Biophysical Research Communications. 165: 695-702. PMID 2480781 DOI: 10.1016/S0006-291X(89)80022-1  0.593
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