David M. Ornitz - Publications

Affiliations: 
Biology & Biomedical Sciences (Molecular Cell Biology) Washington University, Saint Louis, St. Louis, MO 
Area:
Cell Biology

213 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Dong Z, Santeford A, Ban N, Lee TJ, Smith C, Ornitz DM, Apte RS. FGF2-induced STAT3 activation regulates pathologic neovascularization. Experimental Eye Research. 107775. PMID 31449793 DOI: 10.1016/j.exer.2019.107775  0.56
2019 Hagan AS, Boylan M, Smith C, Perez-Santamarina E, Kowalska K, Hung IH, Lewis RM, Hajihosseini MK, Lewandoski M, Ornitz DM. Generation and validation of novel conditional flox and inducible Cre alleles targeting fibroblast growth factor 18 (Fgf18). Developmental Dynamics : An Official Publication of the American Association of Anatomists. PMID 31290205 DOI: 10.1002/dvdy.85  0.64
2019 Yang LM, Cheah KSE, Huh SH, Ornitz DM. Sox2 and FGF20 interact to regulate organ of Corti hair cell and supporting cell development in a spatially-graded manner. Plos Genetics. 15: e1008254. PMID 31276493 DOI: 10.1371/journal.pgen.1008254  0.92
2019 McKenzie J, Smith C, Karuppaiah K, Langberg J, Silva MJ, Ornitz DM. Osteocyte Death and Bone Overgrowth in Mice Lacking Fibroblast Growth Factor Receptors 1 and 2 in Mature Osteoblasts and Osteocytes. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 31206783 DOI: 10.1002/jbmr.3742  0.48
2019 Hegab AE, Ozaki M, Kameyama N, Gao J, Kagawa S, Yasuda H, Soejima K, Yin Y, Guzy RD, Nakamura Y, Ornitz DM, Betsuyaku T. Effect of FGF/FGFR pathway blocking on lung adenocarcinoma and its cancer-associated fibroblasts. The Journal of Pathology. PMID 31090071 DOI: 10.1002/path.5290  0.4
2019 McKey J, Bunce C, Batchvarov IS, Ornitz DM, Capel B. Neural crest-derived neurons invade the ovary but not the testis during mouse gonad development. Proceedings of the National Academy of Sciences of the United States of America. PMID 30819894 DOI: 10.1073/pnas.1814930116  0.4
2018 Mok KW, Saxena N, Heitman N, Grisanti L, Srivastava D, Muraro MJ, Jacob T, Sennett R, Wang Z, Su Y, Yang LM, Ma'ayan A, Ornitz DM, Kasper M, Rendl M. Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent. Developmental Cell. PMID 30595537 DOI: 10.1016/j.devcel.2018.11.034  0.56
2018 Oladipupo SS, Kabir AU, Smith C, Choi K, Ornitz DM. Impaired tumor growth and angiogenesis in mice heterozygous for Vegfr2 (Flk1). Scientific Reports. 8: 14724. PMID 30283071 DOI: 10.1038/s41598-018-33037-2  0.68
2018 Yang LM, Ornitz DM. Sculpting the skull through neurosensory epithelial-mesenchymal signaling. Developmental Dynamics : An Official Publication of the American Association of Anatomists. PMID 30117627 DOI: 10.1002/dvdy.24664  0.56
2018 Yang LM, Huh SH, Ornitz DM. FGF20-Expressing, Wnt-Responsive Olfactory Epithelial Progenitors Regulate Underlying Turbinate Growth to Optimize Surface Area. Developmental Cell. PMID 30100263 DOI: 10.1016/j.devcel.2018.07.010  0.92
2018 Koo HY, El-Baz LMF, House SL, Cilvik SN, Dorry SJ, Shoukry NM, Salem ML, Hafez HS, Dulin NO, Ornitz DM, Guzy RD. Fibroblast growth factor 2 decreases bleomycin-induced pulmonary fibrosis and inhibits fibroblast collagen production and myofibroblast differentiation. The Journal of Pathology. PMID 29873400 DOI: 10.1002/path.5106  0.32
2018 Hegab AE, Ozaki M, Kagawa S, Hamamoto J, Yasuda H, Naoki K, Soejima K, Yin Y, Kinoshita T, Yaguchi T, Kawakami Y, Ornitz DM, Betsuyaku T. Tumor associated macrophages support the growth of FGF9-induced lung adenocarcinoma by multiple mechanisms. Lung Cancer (Amsterdam, Netherlands). 119: 25-35. PMID 29656749 DOI: 10.1016/j.lungcan.2018.02.015  0.4
2017 Elo T, Lindfors PH, Lan Q, Voutilainen M, Trela E, Ohlsson C, Huh SH, Ornitz DM, Poutanen M, Howard BA, Mikkola ML. Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty. Scientific Reports. 7: 5049. PMID 28698625 DOI: 10.1038/s41598-017-04637-1  0.92
2017 Guzy RD, Li L, Smith C, Dorry SJ, Koo HY, Chen L, Ornitz DM. Pulmonary fibrosis requires cell-autonomous mesenchymal fibroblast growth factor (FGF) signaling. The Journal of Biological Chemistry. PMID 28487375 DOI: 10.1074/jbc.M117.791764  0.48
2016 Öztürk E, Arlov Ø, Aksel S, Li L, Ornitz DM, Skjåk-Bræk G, Zenobi-Wong M. Sulfated hydrogel matrices direct mitogenicity and maintenance of chondrocyte phenotype through activation of FGF signaling. Advanced Functional Materials. 26: 3649-3662. PMID 28919847 DOI: 10.1002/adfm.201600092  0.48
2016 Zhang H, Kamiya N, Tsuji T, Takeda H, Scott G, Rajderkar S, Ray MK, Mochida Y, Allen B, Lefebvre V, Hung IH, Ornitz DM, Kunieda T, Mishina Y. Elevated Fibroblast Growth Factor Signaling Is Critical for the Pathogenesis of the Dwarfism in Evc2/Limbin Mutant Mice. Plos Genetics. 12: e1006510. PMID 28027321 DOI: 10.1371/journal.pgen.1006510  0.68
2016 Xia X, Kumru OS, Blaber SI, Middaugh CR, Li L, Ornitz DM, Suh JM, Atkins AR, Downes M, Evans RM, Tenorio CA, Bienkiewicz E, Blaber M. An S116R Phosphorylation Site Mutation in Human Fibroblast Growth Factor-1 Differentially Affects Mitogenic and Glucose-Lowering Activities. Journal of Pharmaceutical Sciences. 105: 3507-3519. PMID 27773526 DOI: 10.1016/j.xphs.2016.09.005  0.48
2016 Yin Y, Ren X, Smith C, Guo Q, Malabunga M, Guernah I, Zhang Y, Shen J, Sun H, Chehab N, Loizos N, Ludwig DL, Ornitz DM. Inhibition of FGF Receptor 3-dependent lung adenocarcinoma with a human monoclonal antibody. Disease Models & Mechanisms. PMID 27056048 DOI: 10.1242/dmm.024760  0.96
2016 Karuppaiah K, Yu K, Lim J, Chen J, Smith C, Long F, Ornitz DM. FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth. Development (Cambridge, England). PMID 27052727 DOI: 10.1242/dev.131722  0.96
2016 Xia X, Kumru OS, Blaber SI, Middaugh CR, Li L, Ornitz DM, Sutherland MA, Tenorio CA, Blaber M. Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application. Journal of Pharmaceutical Sciences. 105: 1444-53. PMID 27019961 DOI: 10.1016/j.xphs.2016.02.010  0.48
2016 Redmann V, Lamb CA, Hwang S, Orchard RC, Kim S, Razi M, Milam A, Park S, Yokoyama CC, Kambal A, Kreamalmeyer D, Bosch MK, Xiao M, Green K, Kim J, ... ... Ornitz DM, et al. Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival. Scientific Reports. 6: 23326. PMID 26987296 DOI: 10.1038/srep23326  0.96
2016 Bosch MK, Nerbonne JM, Townsend RR, Miyazaki H, Nukina N, Ornitz DM, Marionneau C. Proteomic Analysis of Native Cerebellar iFGF14 Complexes. Channels (Austin, Tex.). 0. PMID 26889602 DOI: 10.1080/19336950.2016.1153203  0.96
2016 Hung IH, Schoenwolf GC, Lewandoski M, Ornitz DM. A combined series of Fgf9 and Fgf18 mutant alleles identifies unique and redundant roles in skeletal development. Developmental Biology. PMID 26794256 DOI: 10.1016/j.ydbio.2016.01.008  0.96
2016 House SL, Castro AM, Lupu TS, Weinheimer C, Smith C, Kovacs A, Ornitz DM. Endothelial Fibroblast Growth Factor Receptor signaling is required for vascular remodeling following cardiac ischemia-reperfusion injury. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00758.2015. PMID 26747503 DOI: 10.1152/ajpheart.00758.2015  0.48
2015 Luo X, Fu Y, Loza AJ, Murali B, Leahy KM, Ruhland MK, Gang M, Su X, Zamani A, Shi Y, Lavine KJ, Ornitz DM, Weilbaecher KN, Long F, Novack DV, et al. Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development. Cell Reports. PMID 26725121 DOI: 10.1016/j.celrep.2015.12.016  0.96
2015 Park C, Lee TJ, Bhang SH, Liu F, Nakamura R, Oladipupo SS, Pitha-Rowe I, Capoccia B, Choi HS, Kim TM, Urao N, Ushio-Fukai M, Lee DJ, Miyoshi H, Kim BS, ... ... Ornitz DM, et al. Injury-Mediated Vascular Regeneration Requires Endothelial ER71/ETV2. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 26586661 DOI: 10.1161/ATVBAHA.115.306430  0.56
2015 Yu K, Karuppaiah K, Ornitz DM. Mesenchymal fibroblast growth factor receptor signaling regulates palatal shelf elevation during secondary palate formation. Developmental Dynamics : An Official Publication of the American Association of Anatomists. PMID 26250517 DOI: 10.1002/dvdy.24319  0.96
2015 Ornitz DM, Marie PJ. Fibroblast growth factor signaling in skeletal development and disease. Genes & Development. 29: 1463-86. PMID 26220993 DOI: 10.1101/gad.266551.115  0.96
2015 Yin Y, Castro AM, Hoekstra M, Yan TJ, Kanakamedala AC, Dehner LP, Hill DA, Ornitz DM. Fibroblast Growth Factor 9 Regulation by MicroRNAs Controls Lung Development and Links DICER1 Loss to the Pathogenesis of Pleuropulmonary Blastoma. Plos Genetics. 11: e1005242. PMID 25978641 DOI: 10.1371/journal.pgen.1005242  0.96
2015 Bosch MK, Carrasquillo Y, Ransdell JL, Kanakamedala A, Ornitz DM, Nerbonne JM. Intracellular FGF14 (iFGF14) Is Required for Spontaneous and Evoked Firing in Cerebellar Purkinje Neurons and for Motor Coordination and Balance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6752-69. PMID 25926453 DOI: 10.1523/JNEUROSCI.2663-14.2015  0.96
2015 Huh SH, Warchol ME, Ornitz DM. Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling. Elife. 4. PMID 25915623 DOI: 10.7554/eLife.05921  0.96
2015 Ornitz DM, Itoh N. The Fibroblast Growth Factor signaling pathway. Wiley Interdisciplinary Reviews. Developmental Biology. 4: 215-66. PMID 25772309 DOI: 10.1002/wdev.176  0.96
2015 Okazawa M, Murashima A, Harada M, Nakagata N, Noguchi M, Morimoto M, Kimura T, Ornitz DM, Yamada G. Region-specific regulation of cell proliferation by FGF receptor signaling during the Wolffian duct development. Developmental Biology. 400: 139-47. PMID 25678108 DOI: 10.1016/j.ydbio.2015.01.023  0.96
2015 House SL, Wang J, Castro AM, Weinheimer C, Kovacs A, Ornitz DM. Fibroblast growth factor 2 is an essential cardioprotective factor in a closed-chest model of cardiac ischemia-reperfusion injury. Physiological Reports. 3. PMID 25626875 DOI: 10.14814/phy2.12278  0.48
2015 Arai D, Hegab AE, Soejima K, Kuroda A, Ishioka K, Yasuda H, Naoki K, Kagawa S, Hamamoto J, Yin Y, Ornitz DM, Betsuyaku T. Characterization of the cell of origin and propagation potential of the fibroblast growth factor 9-induced mouse model of lung adenocarcinoma. The Journal of Pathology. 235: 593-605. PMID 25413587 DOI: 10.1002/path.4486  0.96
2015 Guzy RD, Stoilov I, Elton TJ, Mecham RP, Ornitz DM. Fibroblast growth factor 2 is required for epithelial recovery, but not for pulmonary fibrosis, in response to bleomycin. American Journal of Respiratory Cell and Molecular Biology. 52: 116-28. PMID 24988442 DOI: 10.1165/rcmb.2014-0184OC  0.96
2014 Lavine KJ, Epelman S, Uchida K, Weber KJ, Nichols CG, Schilling JD, Ornitz DM, Randolph GJ, Mann DL. Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart. Proceedings of the National Academy of Sciences of the United States of America. 111: 16029-34. PMID 25349429 DOI: 10.1073/pnas.1406508111  0.96
2014 Kim JY, Lee RH, Kim TM, Kim DW, Jeon YJ, Huh SH, Oh SY, Kyba M, Kataoka H, Choi K, Ornitz DM, Chae JI, Park C. OVOL2 is a critical regulator of ER71/ETV2 in generating FLK1+, hematopoietic, and endothelial cells from embryonic stem cells. Blood. 124: 2948-52. PMID 25267199 DOI: 10.1182/blood-2014-03-556332  0.96
2014 Oladipupo SS, Smith C, Santeford A, Park C, Sene A, Wiley LA, Osei-Owusu P, Hsu J, Zapata N, Liu F, Nakamura R, Lavine KJ, Blumer KJ, Choi K, Apte RS, ... Ornitz DM, et al. Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 111: 13379-84. PMID 25139991 DOI: 10.1073/pnas.1324235111  0.96
2014 Bosch MK, Nerbonne JM, Ornitz DM. Dual transgene expression in murine cerebellar Purkinje neurons by viral transduction in vivo. Plos One. 9: e104062. PMID 25093726 DOI: 10.1371/journal.pone.0104062  0.96
2014 Moreland KT, Hong M, Lu W, Rowley CW, Ornitz DM, De Yoreo JJ, Thalmann R. In vitro calcite crystal morphology is modulated by otoconial proteins otolin-1 and otoconin-90. Plos One. 9: e95333. PMID 24748133 DOI: 10.1371/journal.pone.0095333  0.96
2014 Chen J, Shi Y, Regan J, Karuppaiah K, Ornitz DM, Long F. Osx-Cre targets multiple cell types besides osteoblast lineage in postnatal mice. Plos One. 9: e85161. PMID 24454809 DOI: 10.1371/journal.pone.0085161  0.96
2013 Cilvik SN, Wang JI, Lavine KJ, Uchida K, Castro A, Gierasch CM, Weinheimer CJ, House SL, Kovacs A, Nichols CG, Ornitz DM. Fibroblast growth factor receptor 1 signaling in adult cardiomyocytes increases contractility and results in a hypertrophic cardiomyopathy. Plos One. 8: e82979. PMID 24349409 DOI: 10.1371/journal.pone.0082979  0.96
2013 Xiao M, Bosch MK, Nerbonne JM, Ornitz DM. FGF14 localization and organization of the axon initial segment. Molecular and Cellular Neurosciences. 56: 393-403. PMID 23891806 DOI: 10.1016/j.mcn.2013.07.008  0.96
2013 Yin Y, Betsuyaku T, Garbow JR, Miao J, Govindan R, Ornitz DM. Rapid induction of lung adenocarcinoma by fibroblast growth factor 9 signaling through FGF receptor 3. Cancer Research. 73: 5730-41. PMID 23867472 DOI: 10.1158/0008-5472.CAN-13-0495  0.96
2013 Gay D, Kwon O, Zhang Z, Spata M, Plikus MV, Holler PD, Ito M, Yang Z, Treffeisen E, Kim CD, Nace A, Zhang X, Baratono S, Wang F, Ornitz DM, et al. Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding. Nature Medicine. 19: 916-23. PMID 23727932 DOI: 10.1038/nm.3181  0.96
2013 Huh SH, Närhi K, Lindfors PH, Häärä O, Yang L, Ornitz DM, Mikkola ML. Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles. Genes & Development. 27: 450-8. PMID 23431057 DOI: 10.1101/gad.198945.112  0.96
2013 Lin C, Yin Y, Bell SM, Veith GM, Chen H, Huh SH, Ornitz DM, Ma L. Delineating a Conserved Genetic Cassette Promoting Outgrowth of Body Appendages Plos Genetics. 9. PMID 23358455 DOI: 10.1371/journal.pgen.1003231  0.96
2013 Long F, Ornitz DM. Development of the endochondral skeleton. Cold Spring Harbor Perspectives in Biology. 5: a008334. PMID 23284041 DOI: 10.1101/cshperspect.a008334  0.96
2012 Meyer M, Müller AK, Yang J, Moik D, Ponzio G, Ornitz DM, Grose R, Werner S. FGF receptors 1 and 2 are key regulators of keratinocyte migration in vitro and in wounded skin. Journal of Cell Science. 125: 5690-701. PMID 22992463 DOI: 10.1242/jcs.108167  0.96
2012 Häärä O, Harjunmaa E, Lindfors PH, Huh SH, Fliniaux I, Åberg T, Jernvall J, Ornitz DM, Mikkola ML, Thesleff I. Ectodysplasin regulates activator-inhibitor balance in murine tooth development through fgf20 signaling Development (Cambridge). 139: 3189-3199. PMID 22833125 DOI: 10.1242/dev.079558  0.96
2012 Barak H, Huh SH, Chen S, Jeanpierre C, Martinovic J, Parisot M, Bole-Feysot C, Nitschké P, Salomon R, Antignac C, Ornitz DM, Kopan R. FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. Developmental Cell. 22: 1191-207. PMID 22698282 DOI: 10.1016/j.devcel.2012.04.018  0.96
2012 Ornitz DM, Yin Y. Signaling networks regulating development of the lower respiratory tract. Cold Spring Harbor Perspectives in Biology. 4. PMID 22550231 DOI: 10.1101/cshperspect.a008318  0.96
2012 Huh SH, Jones J, Warchol ME, Ornitz DM. Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal. Plos Biology. 10: e1001231. PMID 22235191 DOI: 10.1371/journal.pbio.1001231  0.96
2011 Vega-Hernández M, Kovacs A, De Langhe S, Ornitz DM. FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium. Development (Cambridge, England). 138: 3331-40. PMID 21750042 DOI: 10.1242/dev.064410  0.96
2011 Yin Y, Wang F, Ornitz DM. Mesothelial- and epithelial-derived FGF9 have distinct functions in the regulation of lung development. Development (Cambridge, England). 138: 3169-77. PMID 21750028 DOI: 10.1242/dev.065110  0.96
2011 Yu K, Ornitz DM. Histomorphological study of palatal shelf elevation during murine secondary palate formation. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 240: 1737-44. PMID 21618642 DOI: 10.1002/dvdy.22670  0.96
2011 Hurle B, Marques-Bonet T, Antonacci F, Hughes I, Ryan JF, Eichler EE, Ornitz DM, Green ED. Lineage-specific evolution of the vertebrate Otopetrin gene family revealed by comparative genomic analyses. Bmc Evolutionary Biology. 11: 23. PMID 21261979 DOI: 10.1186/1471-2148-11-23  0.96
2011 Kim E, Hyrc KL, Speck J, Salles FT, Lundberg YW, Goldberg MP, Kachar B, Warchol ME, Ornitz DM. Missense mutations in Otopetrin 1 affect subcellular localization and inhibition of purinergic signaling in vestibular supporting cells. Molecular and Cellular Neurosciences. 46: 655-61. PMID 21236346 DOI: 10.1016/j.mcn.2011.01.005  0.96
2011 Itoh N, Ornitz DM. Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease. Journal of Biochemistry. 149: 121-30. PMID 20940169 DOI: 10.1093/jb/mvq121  0.96
2010 Böhm F, Speicher T, Hellerbrand C, Dickson C, Partanen JM, Ornitz DM, Werner S. FGF receptors 1 and 2 control chemically induced injury and compound detoxification in regenerating livers of mice. Gastroenterology. 139: 1385-96. PMID 20603121 DOI: 10.1053/j.gastro.2010.06.069  0.96
2010 Lu W, Zhou D, Freeman JJ, Thalmann I, Ornitz DM, Thalmann R. In vitro effects of recombinant otoconin 90 upon calcite crystal growth. Significance of tertiary structure. Hearing Research. 268: 172-83. PMID 20595020 DOI: 10.1016/j.heares.2010.05.019  0.96
2010 Kim E, Hyrc KL, Speck J, Lundberg YW, Salles FT, Kachar B, Goldberg MP, Warchol ME, Ornitz DM. Regulation of cellular calcium in vestibular supporting cells by otopetrin 1. Journal of Neurophysiology. 104: 3439-50. PMID 20554841 DOI: 10.1152/jn.00525.2010  0.96
2010 Yang J, Meyer M, Müller AK, Böhm F, Grose R, Dauwalder T, Verrey F, Kopf M, Partanen J, Bloch W, Ornitz DM, Werner S. Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis. The Journal of Cell Biology. 188: 935-52. PMID 20308431 DOI: 10.1083/jcb.200910126  0.96
2010 Huh SH, Ornitz DM. Beta-catenin deficiency causes DiGeorge syndrome-like phenotypes through regulation of Tbx1. Development (Cambridge, England). 137: 1137-47. PMID 20215350 DOI: 10.1242/dev.045534  0.96
2010 Martinez MD, Schmid GJ, McKenzie JA, Ornitz DM, Silva MJ. Healing of non-displaced fractures produced by fatigue loading of the mouse ulna. Bone. 46: 1604-12. PMID 20215063 DOI: 10.1016/j.bone.2010.02.030  0.96
2010 Snyder-Warwick AK, Perlyn CA, Pan J, Yu K, Zhang L, Ornitz DM. Analysis of a gain-of-function FGFR2 Crouzon mutation provides evidence of loss of function activity in the etiology of cleft palate. Proceedings of the National Academy of Sciences of the United States of America. 107: 2515-20. PMID 20133659 DOI: 10.1073/pnas.0913985107  0.96
2010 Lavine KJ, Ornitz DM. The Epicardial Signaling Center in Development and Disease Heart Development and Regeneration. 345-359. DOI: 10.1016/B978-0-12-381332-9.00017-7  0.96
2009 Kalinina J, Byron SA, Makarenkova HP, Olsen SK, Eliseenkova AV, Larochelle WJ, Dhanabal M, Blais S, Ornitz DM, Day LA, Neubert TA, Pollock PM, Mohammadi M. Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix. Molecular and Cellular Biology. 29: 4663-78. PMID 19564416 DOI: 10.1128/MCB.01780-08  0.96
2009 Laezza F, Lampert A, Kozel MA, Gerber BR, Rush AM, Nerbonne JM, Waxman SG, Dib-Hajj SD, Ornitz DM. FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels. Molecular and Cellular Neurosciences. 42: 90-101. PMID 19465131 DOI: 10.1016/j.mcn.2009.05.007  0.96
2009 Goetz R, Dover K, Laezza F, Shtraizent N, Huang X, Tchetchik D, Eliseenkova AV, Xu CF, Neubert TA, Ornitz DM, Goldfarb M, Mohammadi M. Crystal structure of a fibroblast growth factor homologous factor (FHF) defines a conserved surface on FHFs for binding and modulation of voltage-gated sodium channels. The Journal of Biological Chemistry. 284: 17883-96. PMID 19406745 DOI: 10.1074/jbc.M109.001842  0.96
2009 Schmid GJ, Kobayashi C, Sandell LJ, Ornitz DM. Fibroblast growth factor expression during skeletal fracture healing in mice. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 238: 766-74. PMID 19235733 DOI: 10.1002/dvdy.21882  0.96
2009 Harada M, Murakami H, Okawa A, Okimoto N, Hiraoka S, Nakahara T, Akasaka R, Shiraishi Y, Futatsugi N, Mizutani-Koseki Y, Kuroiwa A, Shirouzu M, Yokoyama S, Taiji M, Iseki S, ... Ornitz DM, et al. FGF9 monomer-dimer equilibrium regulates extracellular matrix affinity and tissue diffusion. Nature Genetics. 41: 289-98. PMID 19219044 DOI: 10.1038/ng.316  0.96
2009 Lavine KJ, Ornitz DM. Shared circuitry: developmental signaling cascades regulate both embryonic and adult coronary vasculature. Circulation Research. 104: 159-69. PMID 19179669 DOI: 10.1161/CIRCRESAHA.108.191239  0.96
2009 Shakkottai VG, Xiao M, Xu L, Wong M, Nerbonne JM, Ornitz DM, Yamada KA. FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons. Neurobiology of Disease. 33: 81-8. PMID 18930825 DOI: 10.1016/j.nbd.2008.09.019  0.96
2008 Lavine KJ, Long F, Choi K, Smith C, Ornitz DM. Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development. Development (Cambridge, England). 135: 3161-71. PMID 18725519 DOI: 10.1242/dev.019919  0.96
2008 Geske MJ, Zhang X, Patel KK, Ornitz DM, Stappenbeck TS. Fgf9 signaling regulates small intestinal elongation and mesenchymal development. Development (Cambridge, England). 135: 2959-68. PMID 18653563 DOI: 10.1242/dev.020453  0.96
2008 Lavine KJ, Kovacs A, Ornitz DM. Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice. The Journal of Clinical Investigation. 118: 2404-14. PMID 18568073 DOI: 10.1172/JCI34561  0.96
2008 Yin Y, White AC, Huh SH, Hilton MJ, Kanazawa H, Long F, Ornitz DM. An FGF-WNT gene regulatory network controls lung mesenchyme development. Developmental Biology. 319: 426-36. PMID 18533146 DOI: 10.1016/j.ydbio.2008.04.009  0.96
2008 Zhao H, Yang T, Madakashira BP, Thiels CA, Bechtle CA, Garcia CM, Zhang H, Yu K, Ornitz DM, Beebe DC, Robinson ML. Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation. Developmental Biology. 318: 276-88. PMID 18455718 DOI: 10.1016/j.ydbio.2008.03.028  0.96
2008 Konishi M, Nakamura H, Miwa H, Chambon P, Ornitz DM, Itoh N. Role of Fgf receptor 2c in adipocyte hypertrophy in mesenteric white adipose tissue. Molecular and Cellular Endocrinology. 287: 13-9. PMID 18396371 DOI: 10.1016/j.mce.2008.02.010  0.96
2008 Lavine KJ, Schmid GJ, Smith CS, Ornitz DM. Novel tool to suppress cell proliferation in vivo demonstrates that myocardial and coronary vascular growth represent distinct developmental programs. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 237: 713-24. PMID 18297725 DOI: 10.1002/dvdy.21468  0.96
2008 Hughes I, Binkley J, Hurle B, Green ED, Sidow A, Ornitz DM. Identification of the Otopetrin Domain, a conserved domain in vertebrate otopetrins and invertebrate otopetrin-like family members. Bmc Evolutionary Biology. 8: 41. PMID 18254951 DOI: 10.1186/1471-2148-8-41  0.96
2008 Yu K, Ornitz DM. FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis. Development (Cambridge, England). 135: 483-91. PMID 18094024 DOI: 10.1242/dev.013268  0.96
2008 Itoh N, Ornitz DM. Functional evolutionary history of the mouse Fgf gene family. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 237: 18-27. PMID 18058912 DOI: 10.1002/dvdy.21388  0.96
2008 Lavine KJ, Ornitz DM. Fibroblast growth factors and Hedgehogs: at the heart of the epicardial signaling center. Trends in Genetics : Tig. 24: 33-40. PMID 18054407 DOI: 10.1016/j.tig.2007.10.007  0.96
2007 Laezza F, Gerber BR, Lou JY, Kozel MA, Hartman H, Craig AM, Ornitz DM, Nerbonne JM. The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 12033-44. PMID 17978045 DOI: 10.1523/JNEUROSCI.2282-07.2007  0.96
2007 White AC, Lavine KJ, Ornitz DM. FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network. Development (Cambridge, England). 134: 3743-52. PMID 17881491 DOI: 10.1242/dev.004879  0.96
2007 Saarimäki-Vire J, Peltopuro P, Lahti L, Naserke T, Blak AA, Vogt Weisenhorn DM, Yu K, Ornitz DM, Wurst W, Partanen J. Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 8581-92. PMID 17687036 DOI: 10.1523/JNEUROSCI.0192-07.2007  0.96
2007 Goldfarb M, Schoorlemmer J, Williams A, Diwakar S, Wang Q, Huang X, Giza J, Tchetchik D, Kelley K, Vega A, Matthews G, Rossi P, Ornitz DM, D'Angelo E. Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels. Neuron. 55: 449-63. PMID 17678857 DOI: 10.1016/j.neuron.2007.07.006  0.96
2007 Hughes I, Saito M, Schlesinger PH, Ornitz DM. Otopetrin 1 activation by purinergic nucleotides regulates intracellular calcium. Proceedings of the National Academy of Sciences of the United States of America. 104: 12023-8. PMID 17606897 DOI: 10.1073/pnas.0705182104  0.96
2007 Hung IH, Yu K, Lavine KJ, Ornitz DM. FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod. Developmental Biology. 307: 300-13. PMID 17544391 DOI: 10.1016/j.ydbio.2007.04.048  0.96
2007 Lavine KJ, Ornitz DM. Rebuilding the coronary vasculature: hedgehog as a new candidate for pharmacologic revascularization. Trends in Cardiovascular Medicine. 17: 77-83. PMID 17418368 DOI: 10.1016/j.tcm.2007.01.002  0.96
2007 Wozniak DF, Xiao M, Xu L, Yamada KA, Ornitz DM. Impaired spatial learning and defective theta burst induced LTP in mice lacking fibroblast growth factor 14. Neurobiology of Disease. 26: 14-26. PMID 17236779 DOI: 10.1016/j.nbd.2006.11.014  0.96
2007 Lin Y, Liu G, Zhang Y, Hu YP, Yu K, Lin C, McKeehan K, Xuan JW, Ornitz DM, Shen MM, Greenberg N, McKeehan WL, Wang F. Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis. Development (Cambridge, England). 134: 723-34. PMID 17215304 DOI: 10.1242/dev.02765  0.96
2007 Xiao M, Xu L, Laezza F, Yamada K, Feng S, Ornitz DM. Impaired hippocampal synaptic transmission and plasticity in mice lacking fibroblast growth factor 14. Molecular and Cellular Neurosciences. 34: 366-77. PMID 17208450 DOI: 10.1016/j.mcn.2006.11.020  0.96
2007 Smith SM, West LA, Govindraj P, Zhang X, Ornitz DM, Hassell JR. Heparan and chondroitin sulfate on growth plate perlecan mediate binding and delivery of FGF-2 to FGF receptors. Matrix Biology : Journal of the International Society For Matrix Biology. 26: 175-84. PMID 17169545 DOI: 10.1016/j.matbio.2006.10.012  0.96
2007 Liu Z, Lavine KJ, Hung IH, Ornitz DM. FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate. Developmental Biology. 302: 80-91. PMID 17014841 DOI: 10.1016/j.ydbio.2006.08.071  0.96
2007 Yu K, Ornitz DM. The FGF ligand-receptor signaling system in chondrogenesis, osteogenesis and vascularization of the endochondral skeleton International Congress Series. 1302: 67-78. DOI: 10.1016/j.ics.2006.09.021  0.96
2006 Kaga Y, Shoemaker WJ, Furusho M, Bryant M, Rosenbluth J, Pfeiffer SE, Oh L, Rasband M, Lappe-Siefke C, Yu K, Ornitz DM, Nave KA, Bansal R. Mice with conditional inactivation of fibroblast growth factor receptor-2 signaling in oligodendrocytes have normal myelin but display dramatic hyperactivity when combined with Cnp1 inactivation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 12339-50. PMID 17122059 DOI: 10.1523/JNEUROSCI.3573-06.2006  0.96
2006 Hinoi E, Bialek P, Chen YT, Rached MT, Groner Y, Behringer RR, Ornitz DM, Karsenty G. Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium. Genes & Development. 20: 2937-42. PMID 17050674 DOI: 10.1101/gad.1482906  0.96
2006 Park C, Lavine K, Mishina Y, Deng CX, Ornitz DM, Choi K. Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation. Development (Cambridge, England). 133: 3473-84. PMID 16887829 DOI: 10.1242/dev.02499  0.96
2006 Perlyn CA, Morriss-Kay G, Darvann T, Tenenbaum M, Ornitz DM. A model for the pharmacological treatment of crouzon syndrome. Neurosurgery. 59: 210-5; discussion 21. PMID 16823318 DOI: 10.1227/01.NEU.0000224323.53866.1E  0.96
2006 Gutin G, Fernandes M, Palazzolo L, Paek H, Yu K, Ornitz DM, McConnell SK, Hébert JM. FGF signalling generates ventral telencephalic cells independently of SHH. Development (Cambridge, England). 133: 2937-46. PMID 16818446 DOI: 10.1242/dev.02465  0.96
2006 Jacob AL, Smith C, Partanen J, Ornitz DM. Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation. Developmental Biology. 296: 315-28. PMID 16815385 DOI: 10.1016/j.ydbio.2006.05.031  0.96
2006 Lavine KJ, White AC, Park C, Smith CS, Choi K, Long F, Hui CC, Ornitz DM. Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes & Development. 20: 1651-66. PMID 16778080 DOI: 10.1101/gad.1411406  0.96
2006 Thalmann I, Hughes I, Tong BD, Ornitz DM, Thalmann R. Microscale analysis of proteins in inner ear tissues and fluids with emphasis on endolymphatic sac, otoconia, and organ of Corti. Electrophoresis. 27: 1598-608. PMID 16609936 DOI: 10.1002/elps.200500768  0.96
2006 Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, Ornitz DM. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. The Journal of Biological Chemistry. 281: 15694-700. PMID 16597617 DOI: 10.1074/jbc.M601252200  0.96
2006 White AC, Xu J, Yin Y, Smith C, Schmid G, Ornitz DM. FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains. Development (Cambridge, England). 133: 1507-17. PMID 16540513 DOI: 10.1242/dev.02313  0.96
2006 Hughes I, Thalmann I, Thalmann R, Ornitz DM. Mixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development. Brain Research. 1091: 58-74. PMID 16529728 DOI: 10.1016/j.brainres.2006.01.074  0.96
2006 McDowell LM, Frazier BA, Studelska DR, Giljum K, Chen J, Liu J, Yu K, Ornitz DM, Zhang L. Inhibition or activation of Apert syndrome FGFR2 (S252W) signaling by specific glycosaminoglycans. The Journal of Biological Chemistry. 281: 6924-30. PMID 16373332 DOI: 10.1074/jbc.M512932200  0.96
2006 Zhang X, Stappenbeck TS, White AC, Lavine KJ, Gordon JI, Ornitz DM. Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development. Development (Cambridge, England). 133: 173-80. PMID 16308329 DOI: 10.1242/dev.02175  0.96
2005 Lou JY, Laezza F, Gerber BR, Xiao M, Yamada KA, Hartmann H, Craig AM, Nerbonne JM, Ornitz DM. Fibroblast growth factor 14 is an intracellular modulator of voltage-gated sodium channels. The Journal of Physiology. 569: 179-93. PMID 16166153 DOI: 10.1113/jphysiol.2005.097220  0.96
2005 Yu X, Ibrahimi OA, Goetz R, Zhang F, Davis SI, Garringer HJ, Linhardt RJ, Ornitz DM, Mohammadi M, White KE. Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23. Endocrinology. 146: 4647-56. PMID 16081635 DOI: 10.1210/en.2005-0670  0.96
2005 Wang Y, Xiao R, Yang F, Karim BO, Iacovelli AJ, Cai J, Lerner CP, Richtsmeier JT, Leszl JM, Hill CA, Yu K, Ornitz DM, Elisseeff J, Huso DL, Jabs EW. Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse. Development (Cambridge, England). 132: 3537-48. PMID 15975938 DOI: 10.1242/dev.01914  0.96
2005 Ornitz DM. FGF signaling in the developing endochondral skeleton. Cytokine & Growth Factor Reviews. 16: 205-13. PMID 15863035 DOI: 10.1016/j.cytogfr.2005.02.003  0.96
2005 Garcia CM, Yu K, Zhao H, Ashery-Padan R, Ornitz DM, Robinson ML, Beebe DC. Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 233: 516-27. PMID 15778993 DOI: 10.1002/dvdy.20356  0.96
2005 White KE, Cabral JM, Davis SI, Fishburn T, Evans WE, Ichikawa S, Fields J, Yu X, Shaw NJ, McLellan NJ, McKeown C, Fitzpatrick D, Yu K, Ornitz DM, Econs MJ. Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation. American Journal of Human Genetics. 76: 361-7. PMID 15625620 DOI: 10.1086/427956  0.96
2005 Lavine KJ, Yu K, White AC, Zhang X, Smith C, Partanen J, Ornitz DM. Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo. Developmental Cell. 8: 85-95. PMID 15621532 DOI: 10.1016/j.devcel.2004.12.002  0.96
2005 Hu H, Hilton MJ, Tu X, Yu K, Ornitz DM, Long F. Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development (Cambridge, England). 132: 49-60. PMID 15576404 DOI: 10.1242/dev.01564  0.96
2004 Hughes I, Blasiole B, Huss D, Warchol ME, Rath NP, Hurle B, Ignatova E, Dickman JD, Thalmann R, Levenson R, Ornitz DM. Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio. Developmental Biology. 276: 391-402. PMID 15581873 DOI: 10.1016/j.ydbio.2004.09.001  0.96
2004 Itoh N, Ornitz DM. Evolution of the Fgf and Fgfr gene families. Trends in Genetics : Tig. 20: 563-9. PMID 15475116 DOI: 10.1016/j.tig.2004.08.007  0.96
2004 Pirvola U, Zhang X, Mantela J, Ornitz DM, Ylikoski J. Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactions. Developmental Biology. 273: 350-60. PMID 15328018 DOI: 10.1016/j.ydbio.2004.06.010  0.96
2004 Ignatova EG, Thalmann I, Xu B, Ornitz DM, Thalmann R. Molecular mechanisms underlying ectopic otoconia-like particles in the endolymphatic sac of embryonic mice. Hearing Research. 194: 65-72. PMID 15276677 DOI: 10.1016/j.heares.2004.03.019  0.96
2004 Umemori H, Linhoff MW, Ornitz DM, Sanes JR. FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain. Cell. 118: 257-70. PMID 15260994 DOI: 10.1016/j.cell.2004.06.025  0.96
2004 Schmahl J, Kim Y, Colvin JS, Ornitz DM, Capel B. Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination Development. 131: 3627-3636. PMID 15229180 DOI: 10.1242/dev.01239  0.96
2004 Long H, Sabatier C, Ma L, Plump A, Yuan W, Ornitz DM, Tamada A, Murakami F, Goodman CS, Tessier-Lavigne M. Conserved roles for Slit and Robo proteins in midline commissural axon guidance. Neuron. 42: 213-23. PMID 15091338 DOI: 10.1016/S0896-6273(04)00179-5  0.96
2004 Xiao L, Naganawa T, Obugunde E, Gronowicz G, Ornitz DM, Coffin JD, Hurley MM. Stat1 controls postnatal bone formation by regulating fibroblast growth factor signaling in osteoblasts. The Journal of Biological Chemistry. 279: 27743-52. PMID 15073186 DOI: 10.1074/jbc.M314323200  0.96
2004 Bialek P, Kern B, Yang X, Schrock M, Sosic D, Hong N, Wu H, Yu K, Ornitz DM, Olson EN, Justice MJ, Karsenty G. A twist code determines the onset of osteoblast differentiation. Developmental Cell. 6: 423-35. PMID 15030764 DOI: 10.1016/S1534-5807(04)00058-9  0.96
2004 Amizuka N, Davidson D, Liu H, Valverde-Franco G, Chai S, Maeda T, Ozawa H, Hammond V, Ornitz DM, Goltzman D, Henderson JE. Signalling by fibroblast growth factor receptor 3 and parathyroid hormone-related peptide coordinate cartilage and bone development. Bone. 34: 13-25. PMID 14751559 DOI: 10.1016/j.bone.2003.08.009  0.96
2004 Valverde-Franco G, Liu H, Davidson D, Chai S, Valderrama-Carvajal H, Goltzman D, Ornitz DM, Henderson JE. Defective bone mineralization and osteopenia in young adult FGFR3-/- mice. Human Molecular Genetics. 13: 271-84. PMID 14681299 DOI: 10.1093/hmg/ddh034  0.96
2003 Olsen SK, Garbi M, Zampieri N, Eliseenkova AV, Ornitz DM, Goldfarb M, Mohammadi M. Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs. The Journal of Biological Chemistry. 278: 34226-36. PMID 12815063 DOI: 10.1074/jbc.M303183200  0.96
2003 Yu K, Xu J, Liu Z, Sosic D, Shao J, Olson EN, Towler DA, Ornitz DM. Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth. Development (Cambridge, England). 130: 3063-74. PMID 12756187 DOI: 10.1242/dev.00491  0.96
2003 Yuan W, Rao Y, Babiuk RP, Greer JJ, Wu JY, Ornitz DM. A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3. Proceedings of the National Academy of Sciences of the United States of America. 100: 5217-22. PMID 12702769 DOI: 10.1073/pnas.0730709100  0.96
2003 Hurle B, Ignatova E, Massironi SM, Mashimo T, Rios X, Thalmann I, Thalmann R, Ornitz DM. Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1. Human Molecular Genetics. 12: 777-89. PMID 12651873 DOI: 10.1093/hmg/ddg087  0.96
2003 Oh LY, Denninger A, Colvin JS, Vyas A, Tole S, Ornitz DM, Bansal R. Fibroblast growth factor receptor 3 signaling regulates the onset of oligodendrocyte terminal differentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 883-94. PMID 12574417  0.96
2003 Šošić D, Richardson JA, Yu K, Ornitz DM, Olson EN. Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. Cell. 112: 169-80. PMID 12553906 DOI: 10.1016/S0092-8674(03)00002-3  0.96
2003 Pringle NP, Yu WP, Howell M, Colvin JS, Ornitz DM, Richardson WD. Fgfr3 expression by astrocytes and their precursors: evidence that astrocytes and oligodendrocytes originate in distinct neuroepithelial domains. Development (Cambridge, England). 130: 93-102. PMID 12441294 DOI: 10.1242/dev.00184  0.96
2002 Minina E, Kreschel C, Naski MC, Ornitz DM, Vortkamp A. Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation. Developmental Cell. 3: 439-49. PMID 12361605 DOI: 10.1016/S1534-5807(02)00261-7  0.96
2002 Willis DM, Loewy AP, Charlton-Kachigian N, Shao JS, Ornitz DM, Towler DA. Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex. The Journal of Biological Chemistry. 277: 37280-91. PMID 12145306 DOI: 10.1074/jbc.M206482200  0.96
2002 Wang Q, Bardgett ME, Wong M, Wozniak DF, Lou J, McNeil BD, Chen C, Nardi A, Reid DC, Yamada K, Ornitz DM. Ataxia and paroxysmal dyskinesia in mice lacking axonally transported FGF14. Neuron. 35: 25-38. PMID 12123606 DOI: 10.1016/S0896-6273(02)00744-4  0.96
2002 Ornitz DM, Marie PJ. FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Genes & Development. 16: 1446-65. PMID 12080084 DOI: 10.1101/gad.990702  0.96
2002 Liu Z, Xu J, Colvin JS, Ornitz DM. Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18. Genes & Development. 16: 859-69. PMID 11937493 DOI: 10.1101/gad.965602  0.96
2001 Zhao S, Hung FC, Colvin JS, White A, Dai W, Lovicu FJ, Ornitz DM, Overbeek PA. Patterning the optic neuroepithelium by FGF signaling and Ras activation. Development (Cambridge, England). 128: 5051-60. PMID 11748141  0.96
2001 Thalmann R, Ignatova E, Kachar B, Ornitz DM, Thalmann I. Development and maintenance of otoconia: biochemical considerations. Annals of the New York Academy of Sciences. 942: 162-78. PMID 11710459  0.96
2001 Hurle B, Lane K, Kenney J, Tarantino LM, Bucan M, Brownstein BH, Ornitz DM. Physical mapping of the mouse tilted locus identifies an association between human deafness loci DFNA6/14 and vestibular system development. Genomics. 77: 189-99. PMID 11597144 DOI: 10.1006/geno.2001.6632  0.96
2001 Wang Q, Green RP, Zhao G, Ornitz DM. Differential regulation of endochondral bone growth and joint development by FGFR1 and FGFR3 tyrosine kinase domains Development. 128: 3867-3876. PMID 11585811  0.96
2001 Colvin JS, White AC, Pratt SJ, Ornitz DM. Lung hypoplasia and neonatal death in Fgf9-null mice identify this gene as an essential regulator of lung mesenchyme. Development (Cambridge, England). 128: 2095-106. PMID 11493531  0.96
2001 Ibrahimi OA, Eliseenkova AV, Plotnikov AN, Yu K, Ornitz DM, Mohammadi M. Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome. Proceedings of the National Academy of Sciences of the United States of America. 98: 7182-7. PMID 11390973 DOI: 10.1073/pnas.121183798  0.96
2001 Colvin JS, Green RP, Schmahl J, Capel B, Ornitz DM. Male-to-female sex reversal in mice lacking fibroblast growth factor 9 Cell. 104: 875-889. PMID 11290325 DOI: 10.1016/S0092-8674(01)00284-7  0.96
2001 Ornitz DM. Regulation of chondrocyte growth and differentiation by fibroblast growth factor receptor 3 Novartis Foundation Symposium. 232: 63-76; discussion 76. PMID 11277088  0.96
2001 Yu K, Ornitz DM. Uncoupling fibroblast growth factor receptor 2 ligand binding specificity leads to apert syndrome-like phenotypes Proceedings of the National Academy of Sciences of the United States of America. 98: 3641-3643. PMID 11274381 DOI: 10.1073/pnas.081082498  0.96
2000 Yu K, Herr AB, Waksman G, Ornitz DM. Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome Proceedings of the National Academy of Sciences of the United States of America. 97: 14536-14541. PMID 11121055 DOI: 10.1073/pnas.97.26.14536  0.96
2000 Tarantino LM, Feiner L, Alavizadeh A, Wiltshire T, Hurle B, Ornitz DM, Webber AL, Raper J, Lengeling A, Rowe LB, Bucan M. A high-resolution radiation hybrid map of the proximal portion of mouse chromosome 5. Genomics. 66: 55-64. PMID 10843805 DOI: 10.1006/geno.2000.6183  0.96
2000 Xu J, Liu Z, Ornitz DM. Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures. Development (Cambridge, England). 127: 1833-43. PMID 10751172  0.96
2000 Ornitz DM. FGFs, heparan sulfate and FGFRs: Complex interactions essential for development Bioessays. 22: 108-112. PMID 10655030 DOI: 10.1002/(SICI)1521-1878(200002)22:2<108::AID-BIES2>3.0.CO;2-M  0.96
2000 Henderson JE, Naski MC, Aarts MM, Wang D, Cheng L, Goltzman D, Ornitz DM. Expression of FGFR3 with the G380R achondroplasia mutation inhibits proliferation and maturation of CFK2 chondrocytic cells. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 15: 155-65. PMID 10646125 DOI: 10.1359/jbmr.2000.15.1.155  0.96
2000 Wang Q, McEwen DG, Ornitz DM. Subcellular and developmental expression of alternatively spliced forms of fibroblast growth factor 14 Mechanisms of Development. 90: 283-287. PMID 10640713 DOI: 10.1016/S0925-4773(99)00241-5  0.96
1999 Chellaiah A, Yuan W, Chellaiah M, Ornitz DM. Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity. The Journal of Biological Chemistry. 274: 34785-94. PMID 10574949 DOI: 10.1074/jbc.274.49.34785  0.96
1999 McEwen DG, Green RP, Naski MC, Towler DA, Ornitz DM. Fibroblast growth factor receptor 3 gene transcription is suppressed by cyclic adenosine 3',5'-monophosphate. Identification of a chondrocytic regulatory element Journal of Biological Chemistry. 274: 30934-30942. PMID 10521488 DOI: 10.1074/jbc.274.43.30934  0.96
1999 Colvin JS, Feldman B, Nadeau JH, Goldfarb M, Ornitz DM. Genomic organization and embryonic expression of the mouse fibroblast growth factor 9 gene. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 216: 72-88. PMID 10474167 DOI: 10.1002/(SICI)1097-0177(199909)216:1<72::AID-DVDY9>3.0.CO;2-9  0.96
1999 Yuan W, Zhou L, Chen JH, Wu JY, Rao Y, Ornitz DM. The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance. Developmental Biology. 212: 290-306. PMID 10433822 DOI: 10.1006/dbio.1999.9371  0.96
1999 Xu J, Lawshé A, MacArthur CA, Ornitz DM. Genomic structure, mapping, activity and expression of fibroblast growth factor 17 Mechanisms of Development. 83: 165-178. PMID 10381577 DOI: 10.1016/S0925-4773(99)00034-9  0.96
1999 Wang Y, Thalmann I, Thalmann R, Ornitz DM. Mapping the mouse otoconin-90 (Oc90) gene to chromosome 15 Genomics. 58: 214-215. PMID 10366455 DOI: 10.1006/geno.1999.5821  0.96
1999 Ying HC, Hurlé B, Wang Y, Bohne BA, Wuerffel MK, Ornitz DM. High-resolution mapping of tlt, a mouse mutant lacking otoconia Mammalian Genome. 10: 544-548. PMID 10341082 DOI: 10.1007/s003359901041  0.96
1999 Li HS, Chen JH, Wu W, Fagaly T, Zhou L, Yuan W, Dupuis S, Jiang ZH, Nash W, Gick C, Ornitz DM, Wu JY, Rao Y. Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons. Cell. 96: 807-18. PMID 10102269  0.96
1998 Wang Y, Kowalski PE, Thalmann I, Ornitz DM, Mager DL, Thalmann R. Otoconin-90, the mammalian otoconial matrix protein, contains two domains of homology to secretory phospholipase A2 Proceedings of the National Academy of Sciences of the United States of America. 95: 15345-15350. PMID 9860971 DOI: 10.1073/pnas.95.26.15345  0.96
1998 Daphna-Iken D, Shankar DB, Lawshé A, Ornitz DM, Shackleford GM, MacArthur CA. MMTV-Fgf8 transgenic mice develop mammary and salivary gland neoplasia and ovarian stromal hyperplasia Oncogene. 17: 2711-2717. PMID 9840935  0.96
1998 Naski MC, Colvin JS, Coffin JD, Ornitz DM. Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3. Development (Cambridge, England). 125: 4977-88. PMID 9811582  0.96
1998 Ornitz DM, Bohne BA, Thalmann I, Harding GW, Thalmann R. Otoconial agenesis in tilted mutant mice Hearing Research. 122: 60-70. PMID 9714575 DOI: 10.1016/S0378-5955(98)00080-X  0.96
1998 Lin HY, Xu J, Ischenko I, Ornitz DM, Halegoua S, Hayman MJ. Identification of the cytoplasmic regions of fibroblast growth factor (FGF) receptor 1 which play important roles in induction of neurite outgrowth in PC12 cells by FGF-1 Molecular and Cellular Biology. 18: 3762-3770. PMID 9632759  0.96
1998 Kato M, Wang H, Kainulainen V, Fitzgerald ML, Ledbetter S, Ornitz DM, Bernfield M. Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2. Nature Medicine. 4: 691-7. PMID 9623978 DOI: 10.1038/nm0698-691  0.96
1998 McEwen DG, Ornitz DM. Regulation of the fibroblast growth factor receptor 3 promoter and intron I enhancer by Sp1 family transcription factors Journal of Biological Chemistry. 273: 5349-5357. PMID 9478995 DOI: 10.1074/jbc.273.9.5349  0.96
1998 Xu X, Weinstein M, Li C, Naski M, Cohen RI, Ornitz DM, Leder P, Deng C. Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development (Cambridge, England). 125: 753-65. PMID 9435295  0.96
1998 Naski MC, Ornitz DM. FGF signaling in skeletal development Pediatric Pathology and Molecular Medicine. 18: 355-379.  0.96
1997 Osterhout DJ, Ebner S, Xu J, Ornitz DM, Zazanis GA, McKinnon RD. Transplanted oligodendrocyte progenitor cells expressing a dominant- negative FGF receptor transgene fail to migrate in vivo Journal of Neuroscience. 17: 9122-9132. PMID 9364059  0.96
1997 Herr AB, Ornitz DM, Sasisekharan R, Venkataraman G, Waksman G. Heparin-induced self-association of fibroblast growth factor-2: Evidence for two oligomerization processes Journal of Biological Chemistry. 272: 16382-16389. PMID 9195945 DOI: 10.1074/jbc.272.26.16382  0.96
1997 McEwen DG, Ornitz DM. Determination of fibro-blast growth factor receptor expression in mouse, rat and human samples using a single primer pair Biotechniques. 22: 1068-1070. PMID 9187753  0.96
1997 Miao HQ, Ornitz DM, Aingorn E, Ben-Sasson SA, Vlodavsky I. Modulation of fibroblast growth factor-2 receptor binding, dimerization, signaling, and angiogenic activity by a synthetic heparin-mimicking polyanionic compound Journal of Clinical Investigation. 99: 1565-1575. PMID 9120000  0.96
1997 Blunt AG, Lawshé A, Cunningham ML, Seto ML, Ornitz DM, MacArthur CA. Overlapping expression and redundant activation of mesenchymal fibroblast growth factor (FGF) receptors by alternatively spliced FGF-8 ligands Journal of Biological Chemistry. 272: 3733-3738. PMID 9013630 DOI: 10.1074/jbc.272.6.3733  0.96
1997 Herr AB, Ornitz DM, Sasisekharan R, Voiikatamrnan G, Waksmart G. Sub-populations of heparan sulfate induce active and inactive dimers of fibroblast growth factor-2 Faseb Journal. 11.  0.96
1997 Herr AH, Ornitz DM, Sasisekharan R, Venkataraman G, Waksman U. Unique interactions of fibroblast growth factor-2 with sub-populations of heparan sulfate Faseb Journal. 11.  0.96
1996 Lin HY, Xu J, Ornitz DM, Halegoua S, Hayman MJ. The fibroblast growth factor receptor-1 is necessary for the induction of neurite outgrowth in PC12 cells by aFGF Journal of Neuroscience. 16: 4579-4587. PMID 8764646  0.96
1996 Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M. Receptor specificity of the fibroblast growth factor family. The Journal of Biological Chemistry. 271: 15292-7. PMID 8663044 DOI: 10.1074/jbc.271.25.15292  0.96
1996 Naski MC, Wang Q, Xu J, Ornitz DM. Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia Nature Genetics. 13: 233-237. PMID 8640234 DOI: 10.1038/ng0696-233  0.96
1996 Colvin JS, Bohne BA, Harding GW, McEwen DG, Ornitz DM. Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nature Genetics. 12: 390-7. PMID 8630492 DOI: 10.1038/ng0496-390  0.96
1996 Santos-Ocampo S, Colvin JS, Chellaiah A, Ornitz DM. Expression and biological activity of mouse fibroblast growth factor-9. The Journal of Biological Chemistry. 271: 1726-31. PMID 8576175 DOI: 10.1074/jbc.271.3.1726  0.96
1996 Venkataraman G, Sasisekharan V, Herr AB, Ornitz DM, Waksman G, Cooney CL, Langer R, Sasisekharan R. Preferential self-association of basic fibroblast growth factor is stabilized by heparin during receptor dimerization and activation Proceedings of the National Academy of Sciences of the United States of America. 93: 845-850. PMID 8570646 DOI: 10.1073/pnas.93.2.845  0.96
1995 MacArthur CA, Lawshe A, Xu J, Santos-Ocampo S, Heikinheimo M, Chellaiah AT, Ornitz DM. FGF-8 isoforms activate receptor splice forms that are expressed in mesenchymal regions of mouse development Development. 121: 3603-3613. PMID 8582274  0.96
1995 Benvenisty N, Ornitz DM. BK1: An FGF-responsive central nervous system-derived cell line Growth Factors. 12: 49-55. PMID 8527163 DOI: 10.3109/08977199509003213  0.96
1995 Ornitz DM, Herr AB, Nilsson M, Westman J, Svahn CM, Waksman G. FGF binding and FGF receptor activation by synthetic heparan-derived di- and trisaccharides Science. 268: 432-436. PMID 7536345  0.96
1995 Westman J, Nilsson M, Ornitz DM, Svahn CM. Synthesis and fibroblast growth factor binding of oligosaccharides related to heparin and heparan sulphate Journal of Carbohydrate Chemistry. 14: 95-113. DOI: 10.1080/07328309508006439  0.96
1994 Shen MM, Skoda RC, Cardiff RD, Campos-Torres J, Leder P, Ornitz DM. Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies. The Embo Journal. 13: 1375-85. PMID 8137821  0.96
1994 Deng CX, Wynshaw-Boris A, Shen MM, Daugherty C, Ornitz DM, Leder P. Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes & Development. 8: 3045-57. PMID 8001823  0.96
1994 Chellaiah AT, McEwen DG, Werner S, Xu J, Ornitz DM. Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1 Journal of Biological Chemistry. 269: 11620-11627. PMID 7512569  0.96
1993 Tutrone RF, Ball RA, Ornitz DM, Leder P, Richie JP. Benign prostatic hyperplasia in a transgenic mouse: a new hormonally sensitive investigatory model. The Journal of Urology. 149: 633-9. PMID 7679760  0.96
1992 Benvenisty N, Ornitz DM, Bennett GL, Sahagan BG, Kuo A, Cardiff RD, Leder P. Brain tumours and lymphomas in transgenic mice that carry HTLV-I LTR/c-myc and Ig/tax genes. Oncogene. 7: 2399-405. PMID 1461648  0.96
1992 Ornitz DM, Leder P. Ligand specificity and heparin dependence of fibroblast growth factor receptors 1 and 3. The Journal of Biological Chemistry. 267: 16305-11. PMID 1379594  0.96
1992 Ornitz DM, Cardiff RD, Kuo A, Leder P. Int-2, an autocrine and/or ultra-short-range effector in transgenic mammary tissue transplants. Journal of the National Cancer Institute. 84: 887-92. PMID 1317463 DOI: 10.1093/jnci/84.11.887  0.96
1992 Ornitz DM, Yayon A, Flanagan JG, Svahn CM, Levi E, Leder P. Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells. Molecular and Cellular Biology. 12: 240-7. PMID 1309590  0.96
1991 Yayon A, Klagsbrun M, Esko JD, Leder P, Ornitz DM. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell. 64: 841-8. PMID 1847668 DOI: 10.1016/0092-8674(91)90512-W  0.96
1991 Ornitz DM, Moreadith RW, Leder P. Binary system for regulating transgene expression in mice: targeting int-2 gene expression with yeast GAL4/UAS control elements. Proceedings of the National Academy of Sciences of the United States of America. 88: 698-702. PMID 1846961 DOI: 10.1073/pnas.88.3.698  0.96
1987 Ornitz DM, Hammer RE, Davison BL, Brinster RL, Palmiter RD. Promoter and enhancer elements from the rat elastase I gene function independently of each other and of heterologous enhancers Molecular and Cellular Biology. 7: 3466-3472. PMID 3683390  0.96
1987 Pinkert CA, Ornitz DM, Brinster RL, Palmiter RD. An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice Genes &Amp; Development. 1: 268-276. PMID 3678824  0.96
1987 Hammer RE, Swift GH, Ornitz DM, Quaife CJ, Palmiter RD, Brinster RL, MacDonald RJ. The rat elastase I regulatory element is an enhancer that directs correct cell specificity and developmental onset of expression in transgenic mice Molecular and Cellular Biology. 7: 2956-2967. PMID 3670302  0.96
1987 Quaife CJ, Pinkert CA, Ornitz DM, Palmiter RD, Brinster RL. Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice Cell. 48: 1023-1034. PMID 3470144 DOI: 10.1016/0092-8674(87)90710-0  0.96
1987 MacDonald RJ, Swift GH, Hammer RE, Ornitz DM, Davis BP, Brinster RL, Palmiter RD. Chapter 1 Targeted expression of cloned genes in transgenic mice Progress in Brain Research. 71: 3-12. PMID 3295992 DOI: 10.1016/S0079-6123(08)61809-9  0.96
1987 Ornitz DM, Hammer RE, Messing A, Palmiter RD, Brinster RL. Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice. Science (New York, N.Y.). 238: 188-93. PMID 2821617  0.96
1986 MacDonald RJ, Hammer RE, Swift GH, Ornitz DM, Davis BP, Palmiter RD, Brinster RL. Tissue-specific expression of pancreatic genes in transgenic mice Annals of the New York Academy of Sciences. 478: 131-146. PMID 3541749  0.96
1985 Ornitz DM, Palmiter RD, Hammer RE, Brinster RL, Swift GH, MacDonald RJ. Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice Nature. 313: 600-602. PMID 3844051 DOI: 10.1038/313600a0  0.96
1985 Ornitz DM, Palmiter RD, Messing A, Hammer RE, Pinkert CA, Brinster RL. Elastase I promoter directs expression of human growth hormone and SV40 T antigen genes to pancreatic acinar cells in transgenic mice. Cold Spring Harbor Symposia On Quantitative Biology. 50: 399-409. PMID 3006998  0.96
1985 MacDonald RJ, Swift GH, Ornitz DM. Targeted expression of cloned genes to the pancreas of transgenic mice Federation Proceedings. 44.  0.96
1981 Renosto F, Ornitz DM, Peterson D, Segel IH. Nitrate reductase from Penicillium chrysogenum. Purification and kinetic mechanism Journal of Biological Chemistry. 256: 8616-8625. PMID 6790545  0.96
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