Helen Piwnica-Worms - Publications

Biology & Biomedical Sciences (Molecular Cell Biology) Washington University, Saint Louis, St. Louis, MO 
Molecular Biology, Cell Biology

121/154 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Powell E, Shao J, Yuan Y, Chen HC, Cai S, Echeverria GV, Mistry N, Decker KF, Schlosberg C, Do KA, Edwards JR, Liang H, Piwnica-Worms D, Piwnica-Worms H. p53 deficiency linked to B cell translocation gene 2 (BTG2) loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in patient-derived xenograft (PDX) models of triple-negative breast cancer. Breast Cancer Research : Bcr. 18: 13. PMID 26818199 DOI: 10.1186/s13058-016-0673-9  0.72
2015 Tinkum KL, Stemler KM, White LS, Loza AJ, Jeter-Jones S, Michalski BM, Kuzmicki C, Pless R, Stappenbeck TS, Piwnica-Worms D, Piwnica-Worms H. Fasting protects mice from lethal DNA damage by promoting small intestinal epithelial stem cell survival. Proceedings of the National Academy of Sciences of the United States of America. PMID 26644583 DOI: 10.1073/pnas.1509249112  0.32
2015 Teasley DC, Parajuli S, Nguyen M, Moore HR, Alspach E, Lock YJ, Honaker Y, Saharia A, Piwnica-Worms H, Stewart SA. Flap Endonuclease 1 Limits Telomere Fragility on the Leading Strand. The Journal of Biological Chemistry. 290: 15133-45. PMID 25922071 DOI: 10.1074/jbc.M115.647388  0.72
2015 Chen X, Kim IK, Honaker Y, Paudyal SC, Koh WK, Sparks M, Li S, Piwnica-Worms H, Ellenberger T, You Z. 14-3-3 proteins restrain the Exo1 nuclease to prevent overresection. The Journal of Biological Chemistry. 290: 12300-12. PMID 25833945 DOI: 10.1074/jbc.M115.644005  0.72
2015 Diamond MI, Cai S, Boudreau A, Carey CJ, Lyle N, Pappu RV, Swamidass SJ, Bissell M, Piwnica-Worms H, Shao J. Subcellular localization and Ser-137 phosphorylation regulate tumor-suppressive activity of profilin-1. The Journal of Biological Chemistry. 290: 9075-86. PMID 25681442 DOI: 10.1074/jbc.M114.619874  0.72
2015 Sun L, Miyoshi H, Origanti S, Nice TJ, Barger AC, Manieri NA, Fogel LA, French AR, Piwnica-Worms D, Piwnica-Worms H, Virgin HW, Lenschow DJ, Stappenbeck TS. Type I interferons link viral infection to enhanced epithelial turnover and repair. Cell Host & Microbe. 17: 85-97. PMID 25482432 DOI: 10.1016/j.chom.2014.11.004  0.72
2015 Cheruiyot A, Paudyal SC, Kim IK, Sparks M, Ellenberger T, Piwnica-Worms H, You Z. Poly(ADP-ribose)-binding promotes Exo1 damage recruitment and suppresses its nuclease activities Dna Repair. 35: 106-115. DOI: 10.1016/j.dnarep.2015.09.021  0.72
2014 Powell E, Piwnica-Worms D, Piwnica-Worms H. Contribution of p53 to metastasis. Cancer Discovery. 4: 405-14. PMID 24658082 DOI: 10.1158/2159-8290.CD-13-0136  0.72
2014 Lewandowski KT, Piwnica-Worms H. Phosphorylation of the E3 ubiquitin ligase RNF41 by the kinase Par-1b is required for epithelial cell polarity. Journal of Cell Science. 127: 315-27. PMID 24259665 DOI: 10.1242/jcs.129148  0.72
2013 Tinkum KL, White LS, Marpegan L, Herzog E, Piwnica-Worms D, Piwnica-Worms H. Forkhead box O1 (FOXO1) protein, but not p53, contributes to robust induction of p21 expression in fasted mice. The Journal of Biological Chemistry. 288: 27999-8008. PMID 23918930 DOI: 10.1074/jbc.M113.494328  0.72
2013 Ma CX, Ellis MJ, Petroni GR, Guo Z, Cai SR, Ryan CE, Craig Lockhart A, Naughton MJ, Pluard TJ, Brenin CM, Picus J, Creekmore AN, Mwandoro T, Yarde ER, Reed J, ... ... Piwnica-Worms H, et al. A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer. Breast Cancer Research and Treatment. 137: 483-92. PMID 23242585 DOI: 10.1007/s10549-012-2378-9  0.72
2013 Huh J, Piwnica-Worms H. CRL4(CDT2) targets CHK1 for PCNA-independent destruction. Molecular and Cellular Biology. 33: 213-26. PMID 23109433 DOI: 10.1128/MCB.00847-12  1
2013 Origanti S, Cai SR, Munir AZ, White LS, Piwnica-Worms H. Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells Oncogene. 32: 577-588. PMID 22430210 DOI: 10.1038/onc.2012.84  0.72
2012 Ellis MJ, Ding L, Shen D, Luo J, Suman VJ, Wallis JW, Van Tine BA, Hoog J, Goiffon RJ, Goldstein TC, Ng S, Lin L, Crowder R, Snider J, Ballman K, ... ... Piwnica-Worms H, et al. Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature. 486: 353-60. PMID 22722193 DOI: 10.1038/nature11143  0.72
2012 Duxin JP, Moore HR, Sidorova J, Karanja K, Honaker Y, Dao B, Piwnica-Worms H, Campbell JL, Monnat RJ, Stewart SA. Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication. The Journal of Biological Chemistry. 287: 21980-91. PMID 22570476 DOI: 10.1074/jbc.M112.359018  0.72
2012 Ma CX, Cai S, Li S, Ryan CE, Guo Z, Schaiff WT, Lin L, Hoog J, Goiffon RJ, Prat A, Aft RL, Ellis MJ, Piwnica-Worms H. Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models. The Journal of Clinical Investigation. 122: 1541-52. PMID 22446188 DOI: 10.1172/JCI58765  0.72
2012 Ma CX, Cai S, Li S, Ryan CE, Guo Z, Schaiff WT, Lin L, Hoog J, Goiffon RJ, Prat A, Aft RL, Ellis MJ, Piwnica-Worms H. Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models (Journal of Clinical Investigation (2012) 122, 4 (1541-1552) DOI: 10.1172/JCI58765) Journal of Clinical Investigation. 122: 2702. DOI: 10.1172/JCI64256  0.72
2011 Tinkum KL, Marpegan L, White LS, Sun J, Herzog ED, Piwnica-Worms D, Piwnica-Worms H. Bioluminescence imaging captures the expression and dynamics of endogenous p21 promoter activity in living mice and intact cells. Molecular and Cellular Biology. 31: 3759-72. PMID 21791610 DOI: 10.1128/MCB.05243-11  0.72
2011 Wang YV, Leblanc M, Fox N, Mao JH, Tinkum KL, Krummel K, Engle D, Piwnica-Worms D, Piwnica-Worms H, Balmain A, Kaushansky K, Wahl GM. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes & Development. 25: 1426-38. PMID 21724834 DOI: 10.1101/gad.2024411  0.72
2011 Lee G, Origanti S, White LS, Sun J, Stappenbeck TS, Piwnica-Worms H. Contributions made by CDC25 phosphatases to proliferation of intestinal epithelial stem and progenitor cells. Plos One. 6: e15561. PMID 21283624 DOI: 10.1371/journal.pone.0015561  0.72
2011 Ma CX, Janetka JW, Piwnica-Worms H. Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics Trends in Molecular Medicine. 17: 88-96. PMID 21087899 DOI: 10.1016/j.molmed.2010.10.009  0.72
2011 Fracasso PM, Williams KJ, Chen RC, Picus J, Ma CX, Ellis MJ, Tan BR, Pluard TJ, Adkins DR, Naughton MJ, Rader JS, Arquette MA, Fleshman JW, Creekmore AN, Goodner SA, ... ... Piwnica-Worms H, et al. A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies. Cancer Chemotherapy and Pharmacology. 67: 1225-37. PMID 20694727 DOI: 10.1007/s00280-010-1410-1  0.72
2010 Lennerz JK, Hurov JB, White LS, Lewandowski KT, Prior JL, Planer GJ, Gereau RW, Piwnica-Worms D, Schmidt RE, Piwnica-Worms H. Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis. Molecular and Cellular Biology. 30: 5043-56. PMID 20733003 DOI: 10.1128/MCB.01472-09  0.72
2010 Honaker Y, Piwnica-Worms H. Casein kinase 1 functions as both penultimate and ultimate kinase in regulating Cdc25A destruction Oncogene. 29: 3324-3334. PMID 20348946 DOI: 10.1038/onc.2010.96  0.72
2010 Qian Z, Leung-Pineda V, Xuan B, Piwnica-Worms H, Yu D. Human cytomegalovirus protein pUL117 targets the mini-chromosome maintenance complex and suppresses cellular DNA synthesis. Plos Pathogens. 6: e1000814. PMID 20333247 DOI: 10.1371/journal.ppat.1000814  0.72
2009 Granot Z, Swisa A, Magenheim J, Stolovich-Rain M, Fujimoto W, Manduchi E, Miki T, Lennerz JK, Stoeckert CJ, Meyuhas O, Seino S, Permutt MA, Piwnica-Worms H, Bardeesy N, Dor Y. LKB1 regulates pancreatic beta cell size, polarity, and function. Cell Metabolism. 10: 296-308. PMID 19808022 DOI: 10.1016/j.cmet.2009.08.010  0.72
2009 Lin J, Hou KK, Piwnica-Worms H, Shaw AS. The polarity protein Par1b/EMK/MARK2 regulates T cell receptor-induced microtubule-organizing center polarization. Journal of Immunology (Baltimore, Md. : 1950). 183: 1215-21. PMID 19553522 DOI: 10.4049/jimmunol.0803887  0.72
2009 Leung-Pineda V, Huh J, Piwnica-Worms H. DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress. Cancer Research. 69: 2630-7. PMID 19276361 DOI: 10.1158/0008-5472.CAN-08-3382  0.72
2009 Lee G, White LS, Hurov KE, Stappenbeck TS, Piwnica-Worms H. Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion. Proceedings of the National Academy of Sciences of the United States of America. 106: 4701-6. PMID 19273838 DOI: 10.1073/pnas.0900751106  0.72
2008 Watkins JL, Lewandowski KT, Meek SE, Storz P, Toker A, Piwnica-Worms H. Phosphorylation of the Par-1 polarity kinase by protein kinase D regulates 14-3-3 binding and membrane association. Proceedings of the National Academy of Sciences of the United States of America. 105: 18378-83. PMID 19011111 DOI: 10.1073/pnas.0809661105  0.72
2008 Lovly CM, Yan L, Ryan CE, Takada S, Piwnica-Worms H. Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379. Molecular and Cellular Biology. 28: 5874-85. PMID 18644861 DOI: 10.1128/MCB.00821-08  0.72
2008 Nakajima H, Yonemura S, Murata M, Nakamura N, Piwnica-Worms H, Nishida E. Myt1 protein kinase is essential for Golgi and ER assembly during mitotic exit. The Journal of Cell Biology. 181: 89-103. PMID 18378775 DOI: 10.1083/jcb.200708176  0.72
2008 Kang T, Wei Y, Honaker Y, Yamaguchi H, Appella E, Hung MC, Piwnica-Worms H. GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers. Cancer Cell. 13: 36-47. PMID 18167338 DOI: 10.1016/j.ccr.2007.12.002  0.72
2007 Tarakanova VL, Leung-Pineda V, Hwang S, Yang CW, Matatall K, Basson M, Sun R, Piwnica-Worms H, Sleckman BP, Virgin HW. Gamma-herpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication. Cell Host & Microbe. 1: 275-86. PMID 18005708 DOI: 10.1016/j.chom.2007.05.008  0.72
2007 King JB, Gross J, Lovly CM, Piwnica-Worms H, Townsend RR. Identification of protein phosphorylation sites within Ser/Thr-rich cluster domains using site-directed mutagenesis and hybrid linear quadrupole ion trap Fourier transform ion cyclotron resonance mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 21: 3443-51. PMID 17918214 DOI: 10.1002/rcm.3223  0.72
2007 Hurov J, Piwnica-Worms H. The Par-1/MARK family of protein kinases: from polarity to metabolism. Cell Cycle (Georgetown, Tex.). 6: 1966-9. PMID 17721078  0.72
2007 Hurov JB, Huang M, White LS, Lennerz J, Choi CS, Cho YR, Kim HJ, Prior JL, Piwnica-Worms D, Cantley LC, Kim JK, Shulman GI, Piwnica-Worms H. Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proceedings of the National Academy of Sciences of the United States of America. 104: 5680-5. PMID 17372192 DOI: 10.1073/pnas.0701179104  0.72
2006 Leung-Pineda V, Ryan CE, Piwnica-Worms H. Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit. Molecular and Cellular Biology. 26: 7529-38. PMID 17015476 DOI: 10.1128/MCB.00447-06  0.72
2006 Dequiedt F, Martin M, Von Blume J, Vertommen D, Lecomte E, Mari N, Heinen MF, Bachmann M, Twizere JC, Huang MC, Rider MH, Piwnica-Worms H, Seufferlein T, Kettmann R. New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases. Molecular and Cellular Biology. 26: 7086-102. PMID 16980613 DOI: 10.1128/MCB.00231-06  0.72
2006 Chen YM, Wang QJ, Hu HS, Yu PC, Zhu J, Drewes G, Piwnica-Worms H, Luo ZG. Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity. Proceedings of the National Academy of Sciences of the United States of America. 103: 8534-9. PMID 16717194 DOI: 10.1073/pnas.0509955103  0.72
2006 King JB, Gross J, Lovly CM, Rohrs H, Piwnica-Worms H, Townsend RR. Accurate mass-driven analysis for the characterization of protein phosphorylation. Study of the human Chk2 protein kinase. Analytical Chemistry. 78: 2171-81. PMID 16579595 DOI: 10.1021/ac051520l  0.72
2005 Ferguson AM, White LS, Donovan PJ, Piwnica-Worms H. Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases. Molecular and Cellular Biology. 25: 2853-60. PMID 15767688 DOI: 10.1128/MCB.25.7.2853-2860.2005  0.72
2005 Puc J, Keniry M, Li HS, Pandita TK, Choudhury AD, Memeo L, Mansukhani M, Murty VV, Gaciong Z, Meek SE, Piwnica-Worms H, Hibshoosh H, Parsons R. Lack of PTEN sequesters CHK1 and initiates genetic instability. Cancer Cell. 7: 193-204. PMID 15710331 DOI: 10.1016/j.ccr.2005.01.009  0.72
2004 Murphy CI, Piwnica-Worms H, Grünwald S, Romanow WG, Francis N, Fan HY. Overview of the baculovirus expression system. Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. Unit 16.9. PMID 18265342 DOI: 10.1002/0471142727.mb1609s65  0.72
2004 Murphy CI, Piwnica-Worms H, Grünwald S, Romanow WG, Francis N, Fan HY. Expression and purification of recombinant proteins using the baculovirus system. Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. Unit 16.11. PMID 18265341 DOI: 10.1002/0471142727.mb1611s65  0.72
2004 Murphy CI, Piwnica-Worms H, Grünwald S, Romanow WG, Francis N, Fan HY. Maintenance of insect cell cultures and generation of recombinant baculoviruses. Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. Unit 16.10. PMID 18265340 DOI: 10.1002/0471142727.mb1610s65  0.72
2004 Luker KE, Smith MC, Luker GD, Gammon ST, Piwnica-Worms H, Piwnica-Worms D. Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. Proceedings of the National Academy of Sciences of the United States of America. 101: 12288-93. PMID 15284440 DOI: 10.1073/pnas.0404041101  0.72
2004 Meek SE, Lane WS, Piwnica-Worms H. Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. The Journal of Biological Chemistry. 279: 32046-54. PMID 15161933 DOI: 10.1074/jbc.M403044200  0.72
2004 Hurov JB, Watkins JL, Piwnica-Worms H. Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity. Current Biology : Cb. 14: 736-41. PMID 15084291 DOI: 10.1016/j.cub.2004.04.007  0.72
2003 Chen MS, Ryan CE, Piwnica-Worms H. Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding. Molecular and Cellular Biology. 23: 7488-97. PMID 14559997 DOI: 10.1128/MCB.23.21.7488-7497.2003  0.72
2003 Neely KE, Piwnica-Worms H. Cdc25A regulation: to destroy or not to destroy--is that the only question? Cell Cycle (Georgetown, Tex.). 2: 455-7. PMID 12963843  0.72
2003 Schwarz JK, Lovly CM, Piwnica-Worms H. Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation. Molecular Cancer Research : McR. 1: 598-609. PMID 12805407  0.72
2003 Bulavin DV, Higashimoto Y, Demidenko ZN, Meek S, Graves P, Phillips C, Zhao H, Moody SA, Appella E, Piwnica-Worms H, Fornace AJ. Dual phosphorylation controls Cdc25 phosphatases and mitotic entry. Nature Cell Biology. 5: 545-51. PMID 12766774 DOI: 10.1038/ncb994  0.72
2002 Zhao H, Watkins JL, Piwnica-Worms H. Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. Proceedings of the National Academy of Sciences of the United States of America. 99: 14795-800. PMID 12399544 DOI: 10.1073/pnas.182557299  0.72
2002 Luker GD, Sharma V, Pica CM, Dahlheimer JL, Li W, Ochesky J, Ryan CE, Piwnica-Worms H, Piwnica-Worms D. Noninvasive imaging of protein-protein interactions in living animals. Proceedings of the National Academy of Sciences of the United States of America. 99: 6961-6. PMID 11997447 DOI: 10.1073/pnas.092022399  0.72
2002 Chen F, Zhang Z, Bower J, Lu Y, Leonard SS, Ding M, Castranova V, Piwnica-Worms H, Shi X. Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway. Proceedings of the National Academy of Sciences of the United States of America. 99: 1990-5. PMID 11842186 DOI: 10.1073/pnas.032428899  0.72
2001 Rothblum-Oviatt CJ, Ryan CE, Piwnica-Worms H. 14-3-3 binding regulates catalytic activity of human Wee1 kinase. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 12: 581-9. PMID 11751453  0.72
2001 Müller J, Ory S, Copeland T, Piwnica-Worms H, Morrison DK. C-TAK1 Regulates Ras Signaling by Phosphorylating the MAPK Scaffold, KSR1 Molecular Cell. 8: 983-993. PMID 11741534 DOI: 10.1016/S1097-2765(01)00383-5  0.72
2001 Deming PB, Cistulli CA, Zhao H, Graves PR, Piwnica-Worms H, Paules RS, Downes CS, Kaufmann WK. The human decatenation checkpoint. Proceedings of the National Academy of Sciences of the United States of America. 98: 12044-9. PMID 11593014 DOI: 10.1073/pnas.221430898  0.72
2001 Crawford DF, Piwnica-Worms H. The G2 DNA Damage Checkpoint Delays Expression of Genes Encoding Mitotic Regulators Journal of Biological Chemistry. 276: 37166-37177. PMID 11483598 DOI: 10.1074/jbc.M103414200  0.72
2001 Zhao H, Piwnica-Worms H. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1 Molecular and Cellular Biology. 21: 4129-4139. PMID 11390642 DOI: 10.1128/MCB.21.13.4129-4139.2001  0.72
2001 Chen MS, Hurov J, White LS, Woodford-Thomas T, Piwnica-Worms H. Absence of apparent phenotype in mice lacking Cdc25C protein phosphatase Molecular and Cellular Biology. 21: 3853-3861. PMID 11359894 DOI: 10.1128/MCB.21.12.3853-3861.2001  0.72
2001 Graves PR, Lovly CM, Uy GL, Piwnica-Worms H. Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding. Oncogene. 20: 1839-51. PMID 11313932 DOI: 10.1038/sj.onc.1204259  0.72
2001 Hurov JB, Stappenbeck TS, Zmasek CM, White LS, Ranganath SH, Russell JH, Chan AC, Murphy KM, Piwnica-Worms H. Immune system dysfunction and autoimmune disease in mice lacking Emk (Par-1) protein kinase. Molecular and Cellular Biology. 21: 3206-19. PMID 11287624 DOI: 10.1128/MCB.21.9.3206-3219.2001  0.72
2000 Ahn JY, Schwarz JK, Piwnica-Worms H, Canman CE. Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation. Cancer Research. 60: 5934-6. PMID 11085506  0.72
2000 Graves PR, Yu L, Schwarz JK, Gales J, Sausville EA, O'Connor PM, Piwnica-Worms H. The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. The Journal of Biological Chemistry. 275: 5600-5. PMID 10681541 DOI: 10.1074/jbc.275.8.5600  0.72
1999 Piwnica-Worms H. Fools rush in Nature. 401: 535-537. PMID 10524615 DOI: 10.1038/44029  0.72
1999 Zeng Y, Piwnica-Worms H. DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding Molecular and Cellular Biology. 19: 7410-7419. PMID 10523629  0.72
1999 Liu F, Rothblum-Oviatt C, Ryan CE, Piwnica-Worms H. Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes. Molecular and Cellular Biology. 19: 5113-23. PMID 10373560  0.72
1999 Brown AL, Lee CH, Schwarz JK, Mitiku N, Piwnica-Worms H, Chung JH. A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage. Proceedings of the National Academy of Sciences of the United States of America. 96: 3745-50. PMID 10097108 DOI: 10.1073/pnas.96.7.3745  0.72
1998 Yu L, Orlandi L, Wang P, Orr MS, Senderowicz AM, Sausville EA, Silvestrini R, Watanabe N, Piwnica-Worms H, O'Connor PM. UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C phosphatase Journal of Biological Chemistry. 273: 33455-33464. PMID 9837924 DOI: 10.1074/jbc.273.50.33455  0.72
1998 Zeng Y, Forbes KC, Wu Z, Moreno S, Piwnica-Worms H, Enoch T. Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1. Nature. 395: 507-10. PMID 9774107 DOI: 10.1038/26766  0.72
1998 Thorson JA, Yu LW, Hsu AL, Shih NY, Graves PR, Tanner JW, Allen PM, Piwnica-Worms H, Shaw AS. 14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity. Molecular and Cellular Biology. 18: 5229-38. PMID 9710607 DOI: 10.1128/MCB.18.9.5229  0.72
1998 Fauman EB, Cogswell JP, Lovejoy B, Rocque WJ, Holmes W, Montana VG, Piwnica-Worms H, Rink MJ, Saper MA. Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A. Cell. 93: 617-25. PMID 9604936 DOI: 10.1016/S0092-8674(00)81190-3  0.72
1998 Peng CY, Graves PR, Ogg S, Thoma RS, Byrnes MJ, Wu Z, Stephenson MT, Piwnica-Worms H. C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 9: 197-208. PMID 9543386  0.72
1998 Piwnica-Worms H. Mitonc- and g2 checkpoint-control Faseb Journal. 12.  0.72
1997 Zhang SH, Kobayashi R, Graves PR, Piwnica-Worms H, Tonks NK. Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3β protein Journal of Biological Chemistry. 272: 27281-27287. PMID 9341175 DOI: 10.1074/jbc.272.43.27281  0.72
1997 Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H. Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science (New York, N.Y.). 277: 1501-5. PMID 9278512 DOI: 10.1126/science.277.5331.1501  0.72
1997 Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H, Elledge SJ. Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25 Science. 277: 1497-1501. PMID 9278511 DOI: 10.1126/science.277.5331.1497  0.72
1997 Liu F, Stanton JJ, Wu Z, Piwnica-Worms H. The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex Molecular and Cellular Biology. 17: 571-583. PMID 9001210  0.72
1997 Liu F, Stanton JJ, Wu J, Piwnica-Worms H. The human myt1 kinask preferentially phosphorylates CDC2 on threonine 14 and localizes to the endoplasmic retlum and golgi complex Faseb Journal. 11.  0.72
1997 Peng CY, Gravesl PR, Thoma RS, Shaw AS, Piwnica-Worms H. Reversible phosphorylation and cell cycle control Faseb Journal. 11.  0.72
1996 Piwnica-Worms H. Reversible phosphorylation and mitotic control Journal of Laboratory and Clinical Medicine. 128: 350-354. PMID 8833882  0.72
1995 Parker LL, Sylvestre PJ, Byrnes MJ, Liu F, Piwnica-Worms H. Identification of a 95-kDa WEE1-like tyrosine kinase in HeLa cells. Proceedings of the National Academy of Sciences of the United States of America. 92: 9638-42. PMID 7568188 DOI: 10.1073/pnas.92.21.9638  0.72
1994 Lee MS, Enoch T, Piwnica-Worms H. mik1+ encodes a tyrosine kinase that phosphorylates p34cdc2 on tyrosine 15. The Journal of Biological Chemistry. 269: 30530-7. PMID 7982971  0.72
1994 Ogg S, Gabrielli B, Piwnica-Worms H. Purification of a serine kinase that associates with and phosphorylates human Cdc25C on serine 216 Journal of Biological Chemistry. 269: 30461-30469. PMID 7982962  0.72
1994 Xu M, Sheppard KA, Peng CY, Yee AS, Piwnica-Worms H. Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Molecular and Cellular Biology. 14: 8420-31. PMID 7969176  0.72
1994 Songyang Z, Blechner S, Hoagland N, Hoekstra MF, Piwnica-Worms H, Cantley LC. Use of an oriented peptide library to determine the optimal substrates of protein kinases Current Biology. 4: 973-982. PMID 7874496 DOI: 10.1016/S0960-9822(00)00221-9  0.72
1994 Atherton-Fessler S, Liu F, Gabrielli B, Lee MS, Peng CY, Piwnica-Worms H. Cell cycle regulation of the p34cdc2 inhibitory kinases. Molecular Biology of the Cell. 5: 989-1001. PMID 7841526  0.72
1993 Parker LL, Walter SA, Young PG, Piwnica-Worms H. Phosphorylation and inactivation of the mitotic inhibitor Wee1 by the nim1/cdr1 kinase. Nature. 363: 736-8. PMID 8515817 DOI: 10.1038/363736a0  0.72
1993 Peeper DS, Parker LL, Ewen ME, Toebes M, Hall FL, Xu M, Zantema A, van der Eb AJ, Piwnica-Worms H. A- and B-type cyclins differentially modulate substrate specificity of cyclin-cdk complexes. The Embo Journal. 12: 1947-54. PMID 8491188  0.72
1993 Atherton-Fessler S, Parker LL, Geahlen RL, Piwnica-Worms H. Mechanisms of p34cdc2 regulation. Molecular and Cellular Biology. 13: 1675-85. PMID 8441405 DOI: 10.1128/MCB.13.3.1675  0.72
1993 Atherton-Fessler S, Hannig G, Piwnica-Worms H. Reversible tyrosine phosphorylation and cell cycle control Seminars in Cell and Developmental Biology. 4: 433-442. PMID 8305682  0.72
1993 Baumann K, Mandelkow EM, Biernat J, Piwnica-Worms H, Mandelkow E. Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5. Febs Letters. 336: 417-24. PMID 8282104 DOI: 10.1016/0014-5793(93)80849-P  0.72
1992 Gabrielli BG, Lee MS, Walker DH, Piwnica-Worms H, Maller JL. Cdc25 regulates the phosphorylation and activity of the Xenopus cdk2 protein kinase complex Journal of Biological Chemistry. 267: 18040-18046. PMID 1517236  0.72
1992 Parker LL, Piwnica-Worms H. Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science (New York, N.Y.). 257: 1955-7. PMID 1384126  0.72
1992 Auger KR, Carpenter CL, Shoelson SE, Piwnica-Worms H, Cantley LC. Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitro. The Journal of Biological Chemistry. 267: 5408-15. PMID 1372000  0.72
1992 Lee MS, Ogg S, Xu M, Parker LL, Donoghue DJ, Maller JL, Piwnica-Worms H. cdc25+ encodes a protein phosphatase that dephosphorylates p34cdc2. Molecular Biology of the Cell. 3: 73-84. PMID 1312880 DOI: 10.1091/mbc.3.1.73  0.72
1992 Lydon NB, Gay B, Mett H, Murray B, Liebetanz J, Gutzwiller A, Piwnica-Worms H, Roberts TM, McGlynn E. Purification and biochemical characterization of non-myristoylated recombinant pp60(c-src) kinase Biochemical Journal. 287: 985-993. PMID 1280108  0.72
1991 Parker LL, Atherton-Fessler S, Lee MS, Ogg S, Falk JL, Swenson KI, Piwnica-Worms H. Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1+ dependent manner. The Embo Journal. 10: 1255-63. PMID 1850698  0.72
1991 Piwnica-Worms H, Atherton-Fessler S, Lee MS, Ogg S, Swenson KI, Parker LL. p107wee1 is a serine/threonine and tyrosine kinase that promotes the tyrosine phosphorylation of the cyclin/p34cdc2 complex. Cold Spring Harbor Symposia On Quantitative Biology. 56: 567-76. PMID 1840265  0.72
1991 Roy LM, Swenson KI, Walker DH, Gabrielli BG, Li RS, Piwnica-Worms H, Maller JL. Activation of p34cdc2 kinase by cyclin A Journal of Cell Biology. 113: 507-514. PMID 1826688  0.72
1991 Mamon H, Williams N, Wood K, Frazier AL, Li P, Zmuidzinas A, Kremer N, D'Acangelo G, Qi H, Smith K, Feig L, Piwnica-Worms H, Halegoua S, Roberts T. New perspectives on Raf-1: The involvement of p21(ras) in the activation of Raf-1 and a potential role for Raf-1 in events occurring later in the cell cycle Cold Spring Harbor Symposia On Quantitative Biology. 56: 251-263. PMID 1819489  0.72
1991 Paris J, Swenson K, Piwnica-Worms H, Richter JD. Maturation-specific polyadenylation: In vitro activation by p34cdc2 and phosphorylation of a 58-kD CPE-binding protein Genes and Development. 5: 1697-1708. PMID 1653174  0.72
1990 Furukawa Y, Piwnica-Worms H, Ernst TJ, Kanakura Y, Griffin JD. cdc2 gene expression at the G1 to S transition in human T lymphocytes Science. 250: 805-808. PMID 2237430  0.72
1990 Piwnica-Worms H, Williams NG, Cheng SH, Roberts TM. Regulation of pp60c-src and its interaction with polyomavirus middle T antigen in insect cells Journal of Virology. 64: 61-68. PMID 2152834 DOI: 10.1128/jvi.64.1.61-68.1990  0.72
1990 Swenson KI, Piwnica-Worms H, McNamee H, Paul DL. Tyrosine phosphorylation of the gap junction protein connexin43 is required for the pp60v-src-induced inhibition of communication Cell Regulation. 1: 989-1002. PMID 1966893  0.72
1990 Cohen B, Yoakim M, Piwnica-Worms H, Roberts TM, Schaffhausen BS. Tyrosine phosphorylation is a signal for the trafficking of pp85, an 85-kDa phosphorylated polypeptide associated with phosphatidylinositol kinase activity Proceedings of the National Academy of Sciences of the United States of America. 87: 4458-4462. PMID 1693771  0.72
1990 Swenson KI, Piwnica-Worms H, McNamee H, Paul DL. Tyrosine phosphorylation of the gap junction protein connexin43 is required for the pp60v-src-induced inhibition of communication Molecular Biology of the Cell. 1: 989-1002.  0.72
1989 DeCaprio JA, Ludlow JW, Lynch D, Furukawa Y, Griffin J, Piwnica-Worms H, Huang CM, Livingston DM. The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element Cell. 58: 1085-1095. PMID 2673542 DOI: 10.1016/0092-8674(89)90507-2  0.72
1989 Cheng SH, Harvey R, Piwnica-Worms H, Espino PC, Roberts TM, Smith AE. Mechanism of activation of complexed pp60c-src by the middle T antigen of polyomavirus Current Topics in Microbiology and Immunology. 144: 109-120. PMID 2477197  0.72
1988 Murphy CI, Weiner B, Bikel I, Piwnica-Worms H, Bradley MK, Livingston DM. Purification and functional properties of simian virus 40 large and small T antigen overproduced in insect cells Journal of Virology. 62: 2951-2959. PMID 2969056  0.72
1988 Roberts TM, Kaplan D, Morgan W, Keller T, Mamon H, Piwnica-Worms H, Druker B, Cohen B, Schaffhausen B, Whitman M, Cantley L, Rapp U, Morrison D. Tyrosine phosphorylation in signal transduction Cold Spring Harbor Symposia On Quantitative Biology. 53: 161-171. PMID 2855480 DOI: 10.1101/SQB.1988.053.01.022  0.72
1988 Draetta G, Piwnica-Worms H, Morrison D, Druker B, Roberts T, Beach D. Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate Nature. 336: 738-744. PMID 2462672  0.72
1988 Cheng SH, Piwnica-Worms H, Harvey RW, Roberts TM, Smith AE. The carboxy terminus of pp60(c-src) is a regulatory domain and is involved in complex formation with the middle-T antigen of polyomavirus Molecular and Cellular Biology. 8: 1736-1747. PMID 2454396 DOI: 10.1128/MCB.8.4.1736  0.72
1987 Piwnica-Worms H, Saunders KB, Roberts TM, Smith AE, Cheng SH. Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src Cell. 49: 75-82. PMID 3103926 DOI: 10.1016/0092-8674(87)90757-4  0.72
1986 Piwnica-Worms H, Kaplan DR, Whitman M, Roberts TM. Retrovirus shuttle vector for study of kinase activities of pp60c-src synthesized in vitro and overproduced in vivo Molecular and Cellular Biology. 6: 2033-2040. PMID 2431288 DOI: 10.1128/MCB.6.6.2033  0.72
1986 Gee CE, Griffin J, Sastre L, Miller LJ, Springer TA, Piwnica-Worms H, Roberts TM. Differentiation of myeloid cells is accompanied by increased levels of pp60c-src protein and kinase activity. Proceedings of the National Academy of Sciences of the United States of America. 83: 5131-5. PMID 2425362  0.72
1985 Piwnica-Worms H, Keene JD. Replication of the vesicular stomatitis virus genome in permissive and nonpermissive host cells Journal of Biological Chemistry. 260: 10503-10511. PMID 2993276  0.72
1983 Piwnica-Worms H, Keene JD. Sequential synthesis of small capped RNA transcripts in Vitro by vesicular stomatitis virus Virology. 125: 206-218. PMID 6299007 DOI: 10.1016/0042-6822(83)90074-0  0.72
1982 Kurilla MG, Piwnica-Worms H, Keene JD. Rapid and transient localization of the leader RNA of vesicular stomatitis virus in the nuclei of infected cells Proceedings of the National Academy of Sciences of the United States of America. 79: 5240-5244. PMID 6291035  0.72
Low-probability matches
2019 Li S, Lavagnino Z, Lemacon D, Kong L, Ustione A, Ng X, Zhang Y, Wang Y, Zheng B, Piwnica-Worms H, Vindigni A, Piston DW, You Z. Ca-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection. Molecular Cell. PMID 31053472 DOI: 10.1016/j.molcel.2019.04.003  0.12
2015 Cheruiyot A, Paudyal SC, Kim IK, Sparks M, Ellenberger T, Piwnica-Worms H, You Z. Poly(ADP-ribose)-binding promotes Exo1 damage recruitment and suppresses its nuclease activities. Dna Repair. 35: 106-115. PMID 26519824 DOI: 10.1016/j.dnarep.2015.09.021  0.12
2019 Biagiotti G, Pisaneschi F, Gammon ST, Machetti F, Ligi MC, Giambastiani G, Tuci G, Powell E, Piwnica-Worms H, Pranzini E, Paoli P, Cicchi S, Piwnica-Worms D. Multiwalled Carbon Nanotubes for Combination Therapy: a Biodistribution and Efficacy Pilot Study. Journal of Materials Chemistry. B. 7: 2678-2687. PMID 31073405 DOI: 10.1039/C8TB03299H  0.08
2018 de la Cruz Bonilla M, Stemler KM, Taniguchi CM, Piwnica-Worms H. Stem cell enriched-epithelial spheroid cultures for rapidly assaying small intestinal radioprotectors and radiosensitizers in vitro. Scientific Reports. 8: 15410. PMID 30337664 DOI: 10.1038/s41598-018-33747-7  0.08
2019 Yang H, Shu Z, Jiang Y, Mao W, Pang L, Redwood A, Jeter-Jones SL, Jennings NB, Ornelas A, Zhou J, Rodriguez-Aguayo C, Bartholomeusz G, Iles LR, Zacharias NM, Millward SW, ... ... Piwnica-Worms H, et al. 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-2 Regulates TP53-Dependent Paclitaxel Sensitivity in Ovarian and Breast Cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31391192 DOI: 10.1158/1078-0432.CCR-18-3448  0.04
2019 Bonilla MC, Stemler KM, Jeter-Jones S, Fujimoto TN, Molkentine J, Asencio Torres GM, Zhang X, Broaddus RR, Taniguchi CM, Piwnica-Worms H. Fasting reduces intestinal radiotoxicity enabling dose-escalated radiotherapy for pancreatic cancer. International Journal of Radiation Oncology, Biology, Physics. PMID 31271824 DOI: 10.1016/j.ijrobp.2019.06.2533  0.04
2018 Echeverria GV, Powell E, Seth S, Ge Z, Carugo A, Bristow C, Peoples M, Robinson F, Qiu H, Shao J, Jeter-Jones SL, Zhang X, Ramamoorthy V, Cai S, Wu W, ... ... Piwnica-Worms H, et al. High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer. Nature Communications. 9: 5079. PMID 30498242 DOI: 10.1038/s41467-018-07406-4  0.04
2018 Cha JH, Yang WH, Xia W, Wei Y, Chan LC, Lim SO, Li CW, Kim T, Chang SS, Lee HH, Hsu JL, Wang HL, Kuo CW, Chang WC, Hadad S, ... ... Piwnica-Worms H, et al. Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1. Molecular Cell. 71: 606-620.e7. PMID 30118680 DOI: 10.1016/j.molcel.2018.07.030  0.04
2018 Murphy CI, Piwnica-Worms H, Grünwald S, Romanow WG, Francis N, Fan HY, Marr S. Expression and Purification of Recombinant Proteins Using the Baculovirus System. Current Protocols in Molecular Biology. e61. PMID 29953734 DOI: 10.1002/cpmb.61  0.04
2018 Powell E, Shao J, Picon HM, Bristow C, Ge Z, Peoples M, Robinson F, Jeter-Jones SL, Schlosberg C, Grzeskowiak CL, Yang F, Wu Y, Wistuba I, Moulder SL, Symmans WF, ... ... Piwnica-Worms H, et al. A functional genomic screen in vivo identifies CEACAM5 as a clinically relevant driver of breast cancer metastasis. Npj Breast Cancer. 4: 9. PMID 29736411 DOI: 10.1038/s41523-018-0062-x  0.04
2016 Dobrolecki LE, Airhart SD, Alferez DG, Aparicio S, Behbod F, Bentires-Alj M, Brisken C, Bult CJ, Cai S, Clarke RB, Dowst H, Ellis MJ, Gonzalez-Suarez E, Iggo RD, Kabos P, ... ... Piwnica-Worms H, et al. Patient-derived xenograft (PDX) models in basic and translational breast cancer research. Cancer Metastasis Reviews. PMID 28025748 DOI: 10.1007/s10555-016-9653-x  0.04
2020 Hu X, Harvey SE, Zheng R, Lyu J, Grzeskowiak CL, Powell E, Piwnica-Worms H, Scott KL, Cheng C. The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing. Nature Communications. 11: 486. PMID 31980632 DOI: 10.1038/s41467-020-14304-1  0.01
2019 Litton JK, Scoggins ME, Hess KR, Adrada BE, Murthy RK, Damodaran S, DeSnyder SM, Brewster AM, Barcenas CH, Valero V, Whitman GJ, Schwartz-Gomez J, Mittendorf EA, Thompson AM, Helgason T, ... ... Piwnica-Worms H, et al. Neoadjuvant Talazoparib for Patients With Operable Breast Cancer With a Germline Pathogenic Variant. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO1901304. PMID 31461380 DOI: 10.1200/JCO.19.01304  0.01
2019 Cheng CW, Biton M, Haber AL, Gunduz N, Eng G, Gaynor LT, Tripathi S, Calibasi-Kocal G, Rickelt S, Butty VL, Moreno-Serrano M, Iqbal AM, Bauer-Rowe KE, Imada S, Ulutas MS, ... ... Piwnica-Worms H, et al. Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet. Cell. 178: 1115-1131.e15. PMID 31442404 DOI: 10.1016/j.cell.2019.07.048  0.01
2019 Acharya S, Yao J, Li P, Zhang C, Lowery FJ, Zhang Q, Guo H, Qu J, Yang F, Wistuba II, Piwnica-Worms H, Sahin AA, Yu D. Sphingosine-kinase-1 signaling promotes metastasis of triple-negative breast cancer. Cancer Research. PMID 31239273 DOI: 10.1158/0008-5472.CAN-18-3803  0.01
2019 Fujimoto TN, Colbert LE, Huang Y, Molkentine JM, Deorukhkar A, Baseler L, Bonilla MC, Yu M, Lin D, Gupta S, Cabeceiras PK, Kingsley CV, Tailor RC, Sawakuchi GO, Koay EJ, ... Piwnica-Worms H, et al. Selective EGLN Inhibition Enables Ablative Radiotherapy and Improves Survival in Unresectable Pancreatic Cancer. Cancer Research. 79: 2327-2338. PMID 31043430 DOI: 10.1158/0008-5472.CAN-18-1785  0.01
2019 Echeverria GV, Ge Z, Seth S, Zhang X, Jeter-Jones S, Zhou X, Cai S, Tu Y, McCoy A, Peoples M, Sun Y, Qiu H, Chang Q, Bristow C, Carugo A, ... ... Piwnica-Worms H, et al. Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state. Science Translational Medicine. 11. PMID 30996079 DOI: 10.1126/scitranslmed.aav0936  0.01
2019 Molkentine JM, Fujimoto TN, Horvath TD, Grossberg AJ, Garcia CJG, Deorukhkar A, de la Cruz Bonilla M, Lin D, Samuel ELG, Chan WK, Lorenzi PL, Piwnica-Worms H, Dantzer R, Tour JM, Mason KA, et al. Enteral Activation of WR-2721 Mediates Radioprotection and Improved Survival from Lethal Fractionated Radiation. Scientific Reports. 9: 1949. PMID 30760738 DOI: 10.1038/s41598-018-37147-9  0.01
2019 Seth S, Huo L, Rauch GM, Adrada BE, Piwnica-Worms H, Thompson AM, Mittendorf EA, Litton JK, Symmans WF, Draetta GF, Futreal A, Moulder SL, Chang J. Delineating longitudinal patterns of response to neoadjuvant systemic therapy (NAST) in triple-negative breast cancer (TNBC): Profiling results from a randomized, TNBC enrolling trial to confirm molecular profiling improves survival (ARTEMIS; NCT02276443). Journal of Clinical Oncology. 37: 586-586. DOI: 10.1200/JCO.2019.37.15_SUPPL.586  0.01
2018 Li AG, Murphy EC, Culhane AC, Powell E, Wang H, Bronson RT, Von T, Giobbie-Hurder A, Gelman RS, Briggs KJ, Piwnica-Worms H, Zhao JJ, Kung AL, Kaelin WG, Livingston DM. BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 30254159 DOI: 10.1073/pnas.1807112115  0.01
2018 Sinha VC, Piwnica-Worms H. Intratumoral Heterogeneity in Ductal Carcinoma In Situ: Chaos and Consequence. Journal of Mammary Gland Biology and Neoplasia. PMID 30194658 DOI: 10.1007/s10911-018-9410-6  0.01
2018 Ge Z, Leighton JS, Wang Y, Peng X, Chen Z, Chen H, Sun Y, Yao F, Li J, Zhang H, Liu J, Shriver CD, Hu H, Piwnica-Worms H, et al. Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types. Cell Reports. 23: 213-226.e3. PMID 29617661 DOI: 10.1016/j.celrep.2018.03.047  0.01
2017 Litton JK, Scoggins M, Ramirez DL, Murthy RK, Whitman GJ, Hess KR, Adrada BE, Moulder SL, Barcenas CH, Valero V, Gomez JS, Mittendorf EA, Thompson A, Helgason T, Mills GB, ... Piwnica-Worms H, et al. A feasibility study of neoadjuvant talazoparib for operable breast cancer patients with a germline BRCA mutation demonstrates marked activity. Npj Breast Cancer. 3: 49. PMID 29238749 DOI: 10.1038/s41523-017-0052-4  0.01
2017 Gadhikar MA, Zhang J, Shen L, Rao X, Wang J, Zhao M, Kalu NN, Johnson FM, Byers LA, Heymach J, Hittelman WN, Udayakumar D, Pandita RK, Pandita TK, Pickering CR, ... ... Piwnica-Worms H, et al. CDKN2A/p16 deletion in head and neck cancer cells is associated with Cdk2 activation, replication stress, and vulnerability to Chk1 inhibition. Cancer Research. PMID 29229598 DOI: 10.1158/0008-5472.CAN-17-2802  0.01
2017 Sen T, Tong P, Stewart CA, Cristea S, Valliani A, Shames DS, Redwood A, Fan Y, Li L, Glisson BS, Minna J, Sage J, Gibbons DL, Piwnica-Worms H, Heymach J, et al. CHK1 inhibition in small cell lung cancer produces single-agent activity in biomarker-defined disease subsets and combination activity with cisplatin or olaparib. Cancer Research. PMID 28490518 DOI: 10.1158/0008-5472.CAN-16-3409  0.01
2017 Yam C, Hess KR, Litton JK, Yang WT, Piwnica-Worms H, Mittendorf EA, Ueno NT, Lim B, Murthy RK, Damodaran SK, Helgason T, Huo L, Thompson AM, Gilcrease M, Santiago L, et al. A randomized, triple negative breast cancer enrolling trial to confirm molecular profiling improves survival (ARTEMIS). Journal of Clinical Oncology. 35: TPS590-TPS590. DOI: 10.1200/JCO.2017.35.15_suppl.TPS590  0.01
2016 Werden SJ, Sphyris N, Sarkar TR, Paranjape AN, LaBaff AM, Taube JH, Hollier BG, Ramirez-Peña EQ, Soundararajan R, den Hollander P, Powell E, Echeverria GV, Miura N, Chang JT, Piwnica-Worms H, et al. Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth. Oncogene. PMID 27292262 DOI: 10.1038/onc.2016.203  0.01
2016 Moulder S, Litton J, Mittendorf E, Yang W, Ueno N, Hess K, Valero V, Murthy R, Ibrahim N, Lim B, Arun B, Thompson A, Piwnica-Worms H, Tripathy D, Symmans W. Improving outcomes in triple-negative breast cancer (TNBC) using molecular characterization and diagnostic imaging to identify and treat chemo-insensitive disease Annals of Oncology. 27: vi67. DOI: 10.1093/annonc/mdw364.76  0.01
2016 Litton J, Scoggins M, Ramirez D, Murthy R, Whitman G, Hess K, Adrada B, Moulder S, Barcenas C, Valero V, Booser D, Gomez JS, Mills G, Piwnica-Worms H, Arun B. A pilot study of neoadjuvant talazoparib for early-stage breast cancer patients with a BRCA mutation Annals of Oncology. 27: vi46. DOI: 10.1093/annonc/mdw364.10  0.01
2015 Moulder SL, Ueno NT, Yang WT, Ensor J, Valero V, Litton JK, Murthy RK, Ibrahim NK, Arun B, Mittendorf EA, Hunt K, Meric-Bernstam F, Thompson AM, Piwnica-Worms H, Tripathy D, et al. Women’s triple-negative, first-line treatment: Improving outcomes in triple-negative breast cancer (TNBC) using molecular triaging and diagnostic imaging to guide neoadjuvant therapy (NACT). Journal of Clinical Oncology. 33: TPS1113-TPS1113. DOI: 10.1200/jco.2015.33.15_suppl.tps1113  0.01
2012 Ma CX, Ellis MJ, Petroni GR, Lockhart AC, Naughton M, Pluard TJ, Brenin C, Picus J, Creekmore AN, Mwandoro TN, Guo Z, Cai S, Ryan C, Yarde E, Hoog J, ... ... Piwnica-Worms H, et al. Clinical and correlative science results in a phase II study of UCN-01in combination with irinotecan in recurrent triple-negative breast cancer (TNBC). Journal of Clinical Oncology. 30: 3047-3047. DOI: 10.1200/jco.2012.30.15_suppl.3047  0.01
2010 Piwnica-Worms H, Ma C, Cai S, Ryan C, Guo Z, Li S, Ellis M. 243 Targeting the Chk1/Cdc25A pathway in p53-deficient tumors European Journal of Cancer Supplements. 8: 81. DOI: 10.1016/S1359-6349(10)71948-0  0.01
1992 Parker LL, Atherton-Fessler S, Piwnica-Worms H. p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15. Proceedings of the National Academy of Sciences of the United States of America. 89: 2917-21. PMID 1372994 DOI: 10.1073/pnas.89.7.2917  0.01
Hide low-probability matches.