| Year |
Citation |
Score |
| 2025 |
Ma X, Prokopenko D, Wang N, Aikawa T, Choi Y, Zhang C, Lei D, Ren Y, Kawatani K, Starling SC, Perkerson RB, Roy B, Quintero AC, Parsons TM, Pan Y, ... ... Bu G, et al. Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice. Neurobiology of Disease. 206: 106813. PMID 39880319 DOI: 10.1016/j.nbd.2025.106813 |
0.318 |
|
| 2024 |
Yan T, Heckman MG, Craver EC, Liu CC, Rawlinson BD, Wang X, Murray ME, Dickson DW, Ertekin-Taner N, Lou Z, Bu G, Springer W, Fiesel FC. The UFMylation pathway is impaired in Alzheimer's disease. Molecular Neurodegeneration. 19: 97. PMID 39696466 DOI: 10.1186/s13024-024-00784-y |
0.613 |
|
| 2024 |
Gheni G, Shinohara M, Masuda-Suzukake M, Shindo A, Watanabe A, Kawai K, Bu G, Tomimoto H, Hasegawa M, Sato N. Cerebral hypoperfusion reduces tau accumulation. Annals of Clinical and Translational Neurology. PMID 39621511 DOI: 10.1002/acn3.52247 |
0.307 |
|
| 2024 |
Lu W, Shue F, Kurti A, Jeevaratnam S, Macyczko JR, Roy B, Izhar T, Wang N, Bu G, Kanekiyo T, Li Y. Amyloid pathology and cognitive impairment in hAβ-KI and APP-KI mouse models of Alzheimer's disease. Neurobiology of Aging. 145: 13-23. PMID 39447490 DOI: 10.1016/j.neurobiolaging.2024.10.005 |
0.755 |
|
| 2024 |
Kloske CM, Belloy ME, Blue EE, Bowman GR, Carrillo MC, Chen X, Chiba-Falek O, Davis AA, Paolo GD, Garretti F, Gate D, Golden LR, Heinecke JW, Herz J, Huang Y, ... ... Bu G, et al. Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 39031528 DOI: 10.1002/alz.13877 |
0.807 |
|
| 2024 |
Yan T, Heckman MG, Craver EC, Liu CC, Rawlinson BD, Wang X, Murray ME, Dickson DW, Ertekin-Taner N, Lou Z, Bu G, Springer W, Fiesel FC. The UFMylation pathway is impaired in Alzheimer's disease. Biorxiv : the Preprint Server For Biology. PMID 38903110 DOI: 10.1101/2024.05.24.595755 |
0.613 |
|
| 2024 |
Shue F, White LJ, Hendrix R, Ulrich J, Henson RL, Knight W, Martens YA, Wang N, Roy B, Starling SC, Ren Y, Xiong C, Asmann YW, Syrjanen JA, Vassilaki M, ... ... Bu G, et al. CSF biomarkers of immune activation and Alzheimer's disease for predicting cognitive impairment risk in the elderly. Science Advances. 10: eadk3674. PMID 38569027 DOI: 10.1126/sciadv.adk3674 |
0.74 |
|
| 2024 |
Raulin AC, Doss SV, Heckman MG, Craver EC, Li Z, Ikezu TC, Sekiya H, Liu CC, Martens YA, Rosenberg CL, Kuchenbecker LA, DeTure M, Reichard RR, Nguyen AT, Constantopoulos E, ... ... Bu G, et al. Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer's disease. Acta Neuropathologica Communications. 12: 25. PMID 38336940 DOI: 10.1186/s40478-024-01731-0 |
0.595 |
|
| 2023 |
Liu CC, Wang N, Chen Y, Inoue Y, Shue F, Ren Y, Wang M, Qiao W, Ikezu TC, Li Z, Zhao J, Martens Y, Doss SV, Rosenberg CL, Jeevaratnam S, ... ... Bu G, et al. Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer's disease. Nature Immunology. PMID 37857825 DOI: 10.1038/s41590-023-01640-9 |
0.825 |
|
| 2023 |
Zhao J, Ikezu TC, Lu W, Macyczko JR, Li Y, Lewis-Tuffin LJ, Martens YA, Ren Y, Zhu Y, Asmann YW, Ertekin-Taner N, Kanekiyo T, Bu G. APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids. Stem Cell Research & Therapy. 14: 214. PMID 37605285 DOI: 10.1186/s13287-023-03444-y |
0.334 |
|
| 2023 |
Macyczko JR, Wang N, Lu W, Jeevaratnam S, Shue F, Martens Y, Liu CC, Kanekiyo T, Bu G, Li Y. Upregulation of sFRP1 Is More Profound in Female than Male 5xFAD Mice and Positively Associated with Amyloid Pathology. Journal of Alzheimer's Disease : Jad. PMID 37545238 DOI: 10.3233/JAD-230218 |
0.77 |
|
| 2023 |
Wang W, Li Y, Ma F, Sheng X, Chen K, Zhuo R, Wang C, Zheng H, Zhang YW, Bu G, Chen XF, Zhong L. Microglial repopulation reverses cognitive and synaptic deficits in an Alzheimer's disease model by restoring BDNF signaling. Brain, Behavior, and Immunity. PMID 37482204 DOI: 10.1016/j.bbi.2023.07.011 |
0.356 |
|
| 2023 |
Zhong L, Sheng X, Wang W, Li Y, Zhuo R, Wang K, Zhang L, Hu DD, Hong Y, Chen L, Rao H, Li T, Chen M, Lin Z, Zhang YW, ... ... Bu G, et al. TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration. Immunity. PMID 37442133 DOI: 10.1016/j.immuni.2023.06.016 |
0.358 |
|
| 2023 |
Inoue Y, Shue F, Bu G, Kanekiyo T. Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease. Molecular Neurodegeneration. 18: 46. PMID 37434208 DOI: 10.1186/s13024-023-00640-5 |
0.743 |
|
| 2023 |
Cerneckis J, Bu G, Shi Y. Pushing the boundaries of brain organoids to study Alzheimer's disease. Trends in Molecular Medicine. 29: 659-672. PMID 37353408 DOI: 10.1016/j.molmed.2023.05.007 |
0.363 |
|
| 2023 |
Guo L, Cao J, Hou J, Li Y, Huang M, Zhu L, Zhang L, Lee Y, Duarte ML, Zhou X, Wang M, Liu CC, Martens Y, Chao M, Goate A, ... Bu G, et al. Sex specific molecular networks and key drivers of Alzheimer's disease. Molecular Neurodegeneration. 18: 39. PMID 37340466 DOI: 10.1186/s13024-023-00624-5 |
0.552 |
|
| 2023 |
Qiao W, Chen Y, Zhong J, Madden BJ, Charlesworth CM, Martens YA, Liu CC, Knight J, Ikezu TC, Aishe K, Zhu Y, Meneses A, Rosenberg CL, Kuchenbecker LA, Vanmaele LK, ... ... Bu G, et al. Correction: Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology. Molecular Neurodegeneration. 18: 28. PMID 37118783 DOI: 10.1186/s13024-023-00603-w |
0.771 |
|
| 2023 |
Oue H, Yamazaki Y, Qiao W, Yuanxin C, Ren Y, Kurti A, Shue F, Parsons TM, Perkerson RB, Kawatani K, Wang N, Starling SC, Roy B, Mosneag IE, Aikawa T, ... ... Bu G, et al. LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4. Jci Insight. 8. PMID 37036005 DOI: 10.1172/jci.insight.163822 |
0.804 |
|
| 2023 |
Qiao W, Chen Y, Zhong J, Madden BJ, Charlesworth CM, Martens YA, Liu CC, Knight J, Ikezu TC, Aishe K, Zhu Y, Meneses A, Rosenberg CL, Kuchenbecker LA, Vanmaele LK, ... ... Bu G, et al. Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology. Molecular Neurodegeneration. 18: 8. PMID 36721205 DOI: 10.1186/s13024-023-00599-3 |
0.803 |
|
| 2023 |
Oatman SR, Reddy JS, Quicksall Z, Carrasquillo MM, Wang X, Liu CC, Yamazaki Y, Nguyen TT, Malphrus K, Heckman M, Biswas K, Nho K, Baker M, Martens YA, Zhao N, ... ... Bu G, et al. Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer's disease related proteins. Molecular Neurodegeneration. 18: 2. PMID 36609403 DOI: 10.1186/s13024-022-00592-2 |
0.616 |
|
| 2023 |
Raulin AC, Liu CC, Bu G. An assay to evaluate the capacity of cholesterol acceptors using BODIPY-cholesterol in cells. Star Protocols. 4: 101976. PMID 36598853 DOI: 10.1016/j.xpro.2022.101976 |
0.467 |
|
| 2022 |
Meneses AD, Koga S, Li Z, O'Leary J, Li F, Chen K, Murakami A, Qiao W, Kurti A, Heckman MG, White L, Xie M, Chen Y, Finch NA, Lim MJ, ... ... Bu G, et al. APOE2 Exacerbates TDP-43 Related Toxicity in the Absence of Alzheimer Pathology. Annals of Neurology. PMID 36546684 DOI: 10.1002/ana.26580 |
0.36 |
|
| 2022 |
Wang N, Wang M, Jeevaratnam S, Rosenberg C, Ikezu TC, Shue F, Doss SV, Alnobani A, Martens YA, Wren M, Asmann YW, Zhang B, Bu G, Liu CC. Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination. Molecular Neurodegeneration. 17: 75. PMID 36419137 DOI: 10.1186/s13024-022-00577-1 |
0.771 |
|
| 2022 |
Raulin AC, Doss SV, Trottier ZA, Ikezu TC, Bu G, Liu CC. ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies. Molecular Neurodegeneration. 17: 72. PMID 36348357 DOI: 10.1186/s13024-022-00574-4 |
0.62 |
|
| 2022 |
Macyczko JR, Wang N, Zhao J, Ren Y, Lu W, Ikezu TC, Zhao N, Liu CC, Bu G, Li Y. Suppression of Wnt/β-Catenin Signaling Is Associated with Downregulation of Wnt1, PORCN, and Rspo2 in Alzheimer's Disease. Molecular Neurobiology. PMID 36215026 DOI: 10.1007/s12035-022-03065-1 |
0.565 |
|
| 2022 |
Zhao N, Qiao W, Li F, Ren Y, Zheng J, Martens YA, Wang X, Li L, Liu CC, Chen K, Zhu Y, Ikezu TC, Li Z, Meneses AD, Jin Y, ... ... Bu G, et al. Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia. The Journal of Experimental Medicine. 219. PMID 36107206 DOI: 10.1084/jem.20212479 |
0.589 |
|
| 2022 |
Chen K, Martens YA, Meneses A, Ryu DH, Lu W, Raulin AC, Li F, Zhao J, Chen Y, Jin Y, Linares C, Goodwin M, Li Y, Liu CC, Kanekiyo T, ... ... Bu G, et al. LRP1 is a neuronal receptor for α-synuclein uptake and spread. Molecular Neurodegeneration. 17: 57. PMID 36056345 DOI: 10.1186/s13024-022-00560-w |
0.513 |
|
| 2022 |
Liu CC, Zhao J, Fu Y, Inoue Y, Ren Y, Chen Y, Doss SV, Shue F, Jeevaratnam S, Bastea L, Wang N, Martens YA, Qiao W, Wang M, Zhao N, ... ... Bu G, et al. Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function. Nature Neuroscience. 25: 1020-1033. PMID 35915180 DOI: 10.1038/s41593-022-01127-0 |
0.805 |
|
| 2022 |
Jin Y, Li F, Sonoustoun B, Kondru NC, Martens YA, Qiao W, Heckman MG, Ikezu TC, Li Z, Burgess JD, Amerna D, O'Leary J, DeTure MA, Zhao J, McLean PJ, ... ... Bu G, et al. APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer's disease with Lewy body pathology. Acta Neuropathologica. PMID 35471463 DOI: 10.1007/s00401-022-02421-8 |
0.322 |
|
| 2022 |
Li Y, Macyczko JR, Liu CC, Bu G. ApoE4 reduction: An emerging and promising therapeutic strategy for Alzheimer's disease. Neurobiology of Aging. 115: 20-28. PMID 35453035 DOI: 10.1016/j.neurobiolaging.2022.03.011 |
0.626 |
|
| 2022 |
Li Z, Heckman MG, Kanekiyo T, Martens YA, Day GS, Vassilaki M, Liu CC, Bennett DA, Petersen RC, Zhao N, Bu G. Clinicopathologic Factors Associated With Reversion to Normal Cognition in Patients With Mild Cognitive Impairment. Neurology. PMID 35314499 DOI: 10.1212/WNL.0000000000200387 |
0.421 |
|
| 2022 |
Martens YA, Zhao N, Liu CC, Kanekiyo T, Yang AJ, Goate AM, Holtzman DM, Bu G. ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias. Neuron. PMID 35298921 DOI: 10.1016/j.neuron.2022.03.004 |
0.572 |
|
| 2021 |
Meneses A, Koga S, O'Leary J, Dickson DW, Bu G, Zhao N. TDP-43 Pathology in Alzheimer's Disease. Molecular Neurodegeneration. 16: 84. PMID 34930382 DOI: 10.1186/s13024-021-00503-x |
0.372 |
|
| 2021 |
Xie M, Liu YU, Zhao S, Zhang L, Bosco DB, Pang YP, Zhong J, Sheth U, Martens YA, Zhao N, Liu CC, Zhuang Y, Wang L, Dickson DW, Mattson MP, ... Bu G, et al. TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration. Nature Neuroscience. PMID 34916658 DOI: 10.1038/s41593-021-00975-6 |
0.526 |
|
| 2021 |
Sheng X, Yao Y, Huang R, Xu Y, Zhu Y, Chen L, Zhang L, Wang W, Zhuo R, Can D, Chang CF, Zhang YW, Xu H, Bu G, Zhong L, et al. Identification of the minimal active soluble TREM2 sequence for modulating microglial phenotypes and amyloid pathology. Journal of Neuroinflammation. 18: 286. PMID 34893068 DOI: 10.1186/s12974-021-02340-7 |
0.392 |
|
| 2021 |
Zhao J, Lu W, Ren Y, Fu Y, Martens YA, Shue F, Davis MD, Wang X, Chen K, Li F, Liu CC, Graff-Radford NR, Wszolek ZK, Younkin SG, Brafman DA, ... ... Bu G, et al. Correction to: Apolipoprotein E regulates lipid metabolism and α‑synuclein pathology in human iPSC‑derived cerebral organoids. Acta Neuropathologica. PMID 34724591 DOI: 10.1007/s00401-021-02380-6 |
0.754 |
|
| 2021 |
Liu CC, Murray ME, Li X, Zhao N, Wang N, Heckman MG, Shue F, Martens Y, Li Y, Raulin AC, Rosenberg CL, Doss SV, Zhao J, Wren MC, Jia L, ... ... Bu G, et al. -Jacksonville (V236E) variant reduces self-aggregation and risk of dementia. Science Translational Medicine. 13: eabc9375. PMID 34586832 DOI: 10.1126/scitranslmed.abc9375 |
0.747 |
|
| 2021 |
Zhao J, Lu W, Ren Y, Fu Y, Martens YA, Shue F, Davis MD, Wang X, Chen K, Li F, Liu CC, Graff-Radford NR, Wszolek ZK, Younkin SG, Brafman DA, ... ... Bu G, et al. Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids. Acta Neuropathologica. PMID 34453582 DOI: 10.1007/s00401-021-02361-9 |
0.796 |
|
| 2021 |
Yamazaki A, Shue F, Yamazaki Y, Martens YA, Bu G, Liu CC. Preparation of single cell suspensions enriched in mouse brain vascular cells for single-cell RNA sequencing. Star Protocols. 2: 100715. PMID 34401781 DOI: 10.1016/j.xpro.2021.100715 |
0.749 |
|
| 2021 |
Martens YA, Xu S, Tait R, Li G, Zhao XC, Lu W, Liu CC, Kanekiyo T, Bu G, Zhao J. Generation and validation of knockout human iPSC-derived cerebral organoids. Star Protocols. 2: 100571. PMID 34151296 DOI: 10.1016/j.xpro.2021.100571 |
0.568 |
|
| 2021 |
Reddy JS, Allen M, Ho CCG, Oatman SR, İş Ö, Quicksall ZS, Wang X, Jin J, Patel TA, Carnwath TP, Nguyen TT, Malphrus KG, Lincoln SJ, Carrasquillo MM, Crook JE, ... ... Bu G, et al. Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer's disease. Acta Neuropathologica Communications. 9: 93. PMID 34020725 DOI: 10.1186/s40478-021-01199-2 |
0.353 |
|
| 2021 |
Zhao J, Fu Y, Yamazaki Y, Ren Y, Davis MD, Liu CC, Lu W, Wang X, Chen K, Cherukuri Y, Jia L, Martens YA, Job L, Shue F, Nguyen TT, ... ... Bu G, et al. Author Correction: APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids. Nature Communications. 12: 2707. PMID 33953196 DOI: 10.1038/s41467-021-23081-4 |
0.767 |
|
| 2020 |
Yamazaki Y, Liu CC, Yamazaki A, Shue F, Martens YA, Chen Y, Qiao W, Kurti A, Oue H, Ren Y, Li Y, Aikawa T, Cherukuri Y, Fryer JD, Asmann YW, ... ... Bu G, et al. Vascular ApoE4 Impairs Behavior by Modulating Gliovascular Function. Neuron. PMID 33321072 DOI: 10.1016/j.neuron.2020.11.019 |
0.795 |
|
| 2020 |
Wojtas AM, Sens JP, Kang SS, Baker KE, Berry TJ, Kurti A, Daughrity L, Jansen-West KR, Dickson DW, Petrucelli L, Bu G, Liu CC, Fryer JD. Astrocyte-derived clusterin suppresses amyloid formation in vivo. Molecular Neurodegeneration. 15: 71. PMID 33246484 DOI: 10.1186/s13024-020-00416-1 |
0.614 |
|
| 2020 |
Li Z, Shue F, Zhao N, Shinohara M, Bu G. APOE2: protective mechanism and therapeutic implications for Alzheimer's disease. Molecular Neurodegeneration. 15: 63. PMID 33148290 DOI: 10.1186/s13024-020-00413-4 |
0.773 |
|
| 2020 |
Zhao J, Fu Y, Yamazaki Y, Ren Y, Davis MD, Liu CC, Lu W, Wang X, Chen K, Cherukuri Y, Jia L, Martens YA, Job L, Shue F, Nguyen TT, ... ... Bu G, et al. APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids. Nature Communications. 11: 5540. PMID 33139712 DOI: 10.1038/s41467-020-19264-0 |
0.8 |
|
| 2020 |
Hou X, Watzlawik JO, Cook C, Liu CC, Kang SS, Lin WL, DeTure M, Heckman MG, Diehl NN, Al-Shaikh FSH, Walton RL, Ross OA, Melrose HL, Ertekin-Taner N, Bu G, et al. Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33090691 DOI: 10.1002/alz.12198 |
0.553 |
|
| 2020 |
Shinohara M, Kanekiyo T, Tachibana M, Kurti A, Shinohara M, Fu Y, Zhao J, Han X, Sullivan PM, Rebeck GW, Fryer JD, Heckman MG, Bu G. is associated with longevity independent of Alzheimer's disease. Elife. 9. PMID 33074098 DOI: 10.7554/eLife.62199 |
0.344 |
|
| 2020 |
Liu CC, Yamazaki Y, Heckman MG, Martens YA, Jia L, Yamazaki A, Diehl NN, Zhao J, Zhao N, DeTure M, Davis MD, Felton LM, Qiao W, Li Y, Li H, ... ... Bu G, et al. Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32827351 DOI: 10.1002/Alz.12104 |
0.638 |
|
| 2020 |
Carare RO, Aldea R, Agarwal N, Bacskai BJ, Bechman I, Boche D, Bu G, Bulters D, Clemens A, Counts SE, de Leon M, Eide PK, Fossati S, Greenberg SM, Hamel E, et al. Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12053. PMID 32775596 DOI: 10.1002/Dad2.12053 |
0.427 |
|
| 2020 |
Zhou X, Brooks M, Jiang P, Koga S, Zuberi AR, Baker MC, Parsons TM, Castanedes-Casey M, Phillips V, Librero AL, Kurti A, Fryer JD, Bu G, Lutz C, Dickson DW, et al. Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin-deficient mice. Embo Reports. e50197. PMID 32761777 DOI: 10.15252/Embr.202050197 |
0.331 |
|
| 2020 |
Caselli RJ, Knopman DS, Bu G. An agnostic reevaluation of the amyloid cascade hypothesis of Alzheimer's disease pathogenesis: The role of APP homeostasis. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32588983 DOI: 10.1002/Alz.12124 |
0.477 |
|
| 2020 |
Zhou X, Nicholson AM, Ren Y, Brooks M, Jiang P, Zuberi A, Phuoc HN, Perkerson RB, Matchett B, Parsons TM, Finch NA, Lin W, Qiao W, Castanedes-Casey M, Phillips V, ... ... Bu G, et al. Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies. Brain : a Journal of Neurology. PMID 32504082 DOI: 10.1093/Brain/Awaa141 |
0.35 |
|
| 2020 |
Shinohara M, Tashiro Y, Suzuki K, Fukumori A, Bu G, Sato N. Interaction between genotype and diabetes in cognitive decline. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12006. PMID 32211501 DOI: 10.1002/Dad2.12006 |
0.344 |
|
| 2020 |
Zhao N, Ren Y, Yamazaki Y, Qiao W, Li F, Felton LM, Mahmoudiandehkordi S, Kueider-Paisley A, Sonoustoun B, Arnold M, Shue F, Zheng J, Attrebi ON, Martens YA, Li Z, ... ... Bu G, et al. Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways. Neuron. PMID 32199103 DOI: 10.1016/J.Neuron.2020.02.034 |
0.803 |
|
| 2020 |
Zhao N, Attrebi ON, Ren Y, Qiao W, Sonustun B, Martens YA, Meneses AD, Li F, Shue F, Zheng J, Van Ingelgom AJ, Davis MD, Kurti A, Knight JA, Linares C, ... ... Bu G, et al. APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid. Science Translational Medicine. 12. PMID 32024798 DOI: 10.1126/Scitranslmed.Aay1809 |
0.804 |
|
| 2019 |
Zhou J, Chow HM, Liu Y, Wu D, Shi M, Li J, Wen L, Gao Y, Chen G, Zhuang K, Lin H, Zhang G, Xie W, Li H, Leng L, ... ... Bu G, et al. Cyclin-Dependent Kinase 5-Dependent BAG3 Degradation Modulates Synaptic Protein Turnover. Biological Psychiatry. PMID 31955914 DOI: 10.1016/J.Biopsych.2019.11.013 |
0.332 |
|
| 2019 |
Aikawa T, Ren Y, Yamazaki Y, Tachibana M, Johnson MR, Anderson CT, Martens YA, Holm ML, Asmann YW, Saito T, Saido TC, Fitzgerald ML, Bu G, Kanekiyo T. ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain. Proceedings of the National Academy of Sciences of the United States of America. PMID 31690660 DOI: 10.1073/Pnas.1908529116 |
0.456 |
|
| 2019 |
Yamazaki Y, Shinohara M, Yamazaki A, Ren Y, Asmann YW, Kanekiyo T, Bu G. ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA119313169. PMID 31665905 DOI: 10.1161/Atvbaha.119.313169 |
0.455 |
|
| 2019 |
Yamazaki Y, Zhao N, Caulfield TR, Liu CC, Bu G. Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. Nature Reviews. Neurology. PMID 31367008 DOI: 10.1038/S41582-019-0228-7 |
0.66 |
|
| 2019 |
Zhao S, Li Z, Zhang M, Zhang L, Zheng H, Ning J, Wang Y, Wang F, Zhang X, Gan H, Wang Y, Zhang X, Luo H, Bu G, Xu H, et al. A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II. Experimental & Molecular Medicine. 51: 84. PMID 31337748 DOI: 10.1038/S12276-019-0277-4 |
0.319 |
|
| 2019 |
Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, Wang D, Gao Y, Zhu Y, Sheng X, Chen K, Wang N, Zhu L, Can D, Marten Y, ... ... Bu G, et al. Author Correction: Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model. Nature Communications. 10: 2923. PMID 31266955 DOI: 10.1038/S41467-019-10950-2 |
0.474 |
|
| 2019 |
Shinohara M, Shinohara M, Zhao J, Fu Y, Liu CC, Kanekiyo T, Bu G. 5-HT3 Antagonist Ondansetron Increases apoE Secretion by Modulating the LXR-ABCA1 Pathway. International Journal of Molecular Sciences. 20. PMID 30934555 DOI: 10.3390/Ijms20061488 |
0.613 |
|
| 2019 |
Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, Wang D, Gao Y, Zhu Y, Sheng X, Chen K, Wang N, Zhu L, Can D, Marten Y, ... ... Bu G, et al. Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model. Nature Communications. 10: 1365. PMID 30911003 DOI: 10.1038/S41467-019-09118-9 |
0.677 |
|
| 2019 |
Yamazaki Y, Shinohara M, Shinohara M, Yamazaki A, Murray ME, Liesinger AM, Heckman MG, Lesser ER, Parisi JE, Petersen RC, Dickson DW, Kanekiyo T, Bu G. Selective loss of cortical endothelial tight junction proteins during Alzheimer's disease progression. Brain : a Journal of Neurology. PMID 30770921 DOI: 10.1093/Brain/Awz011 |
0.454 |
|
| 2019 |
Tachibana M, Holm ML, Liu CC, Shinohara M, Aikawa T, Oue H, Yamazaki Y, Martens YA, Murray ME, Sullivan PM, Weyer K, Glerup S, Dickson DW, Bu G, Kanekiyo T. APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1. The Journal of Clinical Investigation. PMID 30741718 DOI: 10.1172/Jci124853 |
0.635 |
|
| 2019 |
Allen M, Reddy JS, Carrasquillo MM, Wang X, Lincoln SJ, Nguyen T, Malphrus KG, Asmann YW, Murray ME, Bu G, Dickson DW, Ertekin-Taner N. INTEGRATIVE GENOMIC PROFILING TO IDENTIFY GENES AND PATHWAYS ASSOCIATED WITH VASCULAR RISK IN AD Alzheimer's & Dementia. 15: P1617. DOI: 10.1016/J.Jalz.2019.06.4843 |
0.334 |
|
| 2018 |
Twohig D, Rodriguez-Vieitez E, Sando SB, Berge G, Lauridsen C, Møller I, Grøntvedt GR, Bråthen G, Patra K, Bu G, Benzinger TLS, Karch CM, Fagan A, Morris JC, Bateman RJ, et al. The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease. Acta Neuropathologica Communications. 6: 130. PMID 30477568 DOI: 10.1186/S40478-018-0624-Z |
0.434 |
|
| 2018 |
Zhao N, Liu CC, Van Ingelgom AJ, Linares C, Kurti A, Knight JA, Heckman MG, Diehl NN, Shinohara M, Martens YA, Attrebi ON, Petrucelli L, Fryer JD, Wszolek ZK, Graff-Radford NR, ... ... Bu G, et al. APOE ε2 is associated with increased tau pathology in primary tauopathy. Nature Communications. 9: 4388. PMID 30348994 DOI: 10.1038/S41467-018-06783-0 |
0.628 |
|
| 2018 |
Zhao D, Meng J, Zhao Y, Huo Y, Liu Y, Zheng N, Zhang M, Gao Y, Chen Z, Sun H, Wang X, Jing C, Zhang T, Zhang X, Luo H, ... ... Bu G, et al. RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer's Disease-Associated Cognitive Deficits. Biological Psychiatry. PMID 30292394 DOI: 10.1016/J.Biopsych.2018.08.009 |
0.395 |
|
| 2018 |
Dickson DW, Heckman MG, Murray ME, Soto AI, Walton RL, Diehl NN, van Gerpen JA, Uitti RJ, Wszolek ZK, Ertekin-Taner N, Knopman DS, Petersen RC, Graff-Radford NR, Boeve BF, Bu G, et al. ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology. Neurology. PMID 30143564 DOI: 10.1212/Wnl.0000000000006212 |
0.406 |
|
| 2018 |
Hettinger JC, Lee H, Bu G, Holtzman DM, Cirrito JR. AMPA-ergic regulation of amyloid-β levels in an Alzheimer's disease mouse model. Molecular Neurodegeneration. 13: 22. PMID 29764453 DOI: 10.1186/S13024-018-0256-6 |
0.468 |
|
| 2018 |
Zhong L, Wang Z, Wang D, Wang Z, Martens YA, Wu L, Xu Y, Wang K, Li J, Huang R, Can D, Xu H, Bu G, Chen XF. Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2). Molecular Neurodegeneration. 13: 15. PMID 29587871 DOI: 10.1186/S13024-018-0247-7 |
0.479 |
|
| 2018 |
Zhao Y, Wu X, Li X, Jiang LL, Gui X, Liu Y, Sun Y, Zhu B, Piña-Crespo JC, Zhang M, Zhang N, Chen X, Bu G, An Z, Huang TY, et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron. 97: 1023-1031.e7. PMID 29518356 DOI: 10.1016/J.Neuron.2018.01.031 |
0.509 |
|
| 2018 |
Yan Y, Song L, Bejoy J, Zhao J, Kanekiyo T, Bu G, Zhou Y, Li Y. Modelling Neurodegenerative Microenvironment Using Cortical Organoids Derived from Human Stem Cells. Tissue Engineering. Part A. PMID 29361890 DOI: 10.1089/Ten.Tea.2017.0423 |
0.328 |
|
| 2017 |
Zhao Y, Li X, Huang T, Jiang LL, Tan Z, Zhang M, Cheng IH, Wang X, Bu G, Zhang YW, Wang Q, Xu H. Intracellular trafficking of TREM2 is regulated by presenilin 1. Experimental & Molecular Medicine. 49: e405. PMID 29611543 DOI: 10.1038/Emm.2017.200 |
0.378 |
|
| 2017 |
Liu CC, Zhao N, Fu Y, Wang N, Linares C, Tsai CW, Bu G. ApoE4 Accelerates Early Seeding of Amyloid Pathology. Neuron. 96: 1024-1032.e3. PMID 29216449 DOI: 10.1016/J.Neuron.2017.11.013 |
0.613 |
|
| 2017 |
Tachibana M, Yamazaki Y, Liu CC, Bu G, Kanekiyo T. Pericyte implantation in the brain enhances cerebral blood flow and reduces amyloid-β pathology in amyloid model mice. Experimental Neurology. 300: 13-21. PMID 29106980 DOI: 10.1016/J.Expneurol.2017.10.023 |
0.616 |
|
| 2017 |
Kang SS, Kurti A, Baker KE, Liu CC, Colonna M, Ulrich JD, Holtzman DM, Bu G, Fryer JD. Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal. Human Molecular Genetics. PMID 29040522 DOI: 10.1093/Hmg/Ddx366 |
0.58 |
|
| 2017 |
Zhao N, Liu CC, Van Ingelgom AJ, Martens YA, Linares C, Knight JA, Painter MM, Sullivan PM, Bu G. Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes. Neuron. 96: 115-129.e5. PMID 28957663 DOI: 10.1016/J.Neuron.2017.09.003 |
0.531 |
|
| 2017 |
Wojtas AM, Kang SS, Olley BM, Gatherer M, Shinohara M, Lozano PA, Liu CC, Kurti A, Baker KE, Dickson DW, Yue M, Petrucelli L, Bu G, Carare RO, Fryer JD. Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways. Proceedings of the National Academy of Sciences of the United States of America. PMID 28701379 DOI: 10.1016/J.Jalz.2017.06.250 |
0.658 |
|
| 2017 |
Zhong L, Zhang ZL, Li X, Liao C, Mou P, Wang T, Wang Z, Wang Z, Wei M, Xu H, Bu G, Chen XF. TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway. Frontiers in Aging Neuroscience. 9: 204. PMID 28680398 DOI: 10.3389/Fnagi.2017.00204 |
0.365 |
|
| 2017 |
Zhao J, Davis MD, Atagi Y, Shinohara M, Graff-Radford NR, Younkin SG, Wszolek ZK, Kanekiyo T, Bu G. APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes. Human Molecular Genetics. PMID 28444230 DOI: 10.1093/Hmg/Ddx155 |
0.403 |
|
| 2017 |
Zhao N, Liu CC, Qiao W, Bu G. Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease. Biological Psychiatry. PMID 28434655 DOI: 10.1016/J.Biopsych.2017.03.003 |
0.632 |
|
| 2017 |
Shinohara M, Tachibana M, Kanekiyo T, Bu G. Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies. Journal of Lipid Research. PMID 28381441 DOI: 10.1194/Jlr.R075796 |
0.5 |
|
| 2017 |
Liu CC, Hu J, Zhao N, Wang J, Na W, Cirrito JR, Kanekiyo T, Holtzman DM, Bu G. Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28275161 DOI: 10.1523/Jneurosci.3442-16.2017 |
0.664 |
|
| 2017 |
Rogers JT, Liu CC, Zhao N, Wang J, Putzke T, Yang L, Shinohara M, Fryer JD, Kanekiyo T, Bu G. Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice. Neurobiology of Aging. 53: 112-121. PMID 28254590 DOI: 10.1016/J.Neurobiolaging.2017.02.001 |
0.451 |
|
| 2017 |
Zhong L, Chen XF, Wang T, Wang Z, Liao C, Wang Z, Huang R, Wang D, Li X, Wu L, Jia L, Zheng H, Painter M, Atagi Y, Liu CC, ... ... Bu G, et al. Soluble TREM2 induces inflammatory responses and enhances microglial survival. The Journal of Experimental Medicine. PMID 28209725 DOI: 10.1084/Jem.20160844 |
0.609 |
|
| 2017 |
Nielsen HM, Chen K, Lee W, Chen Y, Bauer RJ, Reiman E, Caselli R, Bu G. Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism. Alzheimer's Research & Therapy. 9: 5. PMID 28137305 DOI: 10.1186/S13195-016-0231-9 |
0.426 |
|
| 2017 |
Zheng H, Jia L, Liu CC, Li Zhong ZR, Yang L, Chen XF, Fryer JD, Wang X, Zhang YW, Xu H, Bu G. TREM2 promotes microglial survival by activating Wnt/β-catenin pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28077724 DOI: 10.1523/Jneurosci.2459-16.2017 |
0.559 |
|
| 2016 |
Wang X, Zhou Y, Wang J, Tseng IC, Huang T, Zhao Y, Zheng Q, Gao Y, Luo H, Zhang X, Bu G, Hong W, Xu H. SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 12586-12597. PMID 27974614 DOI: 10.1523/Jneurosci.1620-16.2016 |
0.371 |
|
| 2016 |
Yang L, Liu CC, Zheng H, Kanekiyo T, Atagi Y, Jia L, Wang D, N'songo A, Can D, Xu H, Chen XF, Bu G. LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways. Journal of Neuroinflammation. 13: 304. PMID 27931217 DOI: 10.1186/S12974-016-0772-7 |
0.63 |
|
| 2016 |
Cheng J, Guo X, Zhang T, Zhong L, Bu G, Chen X. TREMs in Alzheimer's disease: Genetic and clinical investigations. Clinica Chimica Acta; International Journal of Clinical Chemistry. 463: 88-95. PMID 27769848 DOI: 10.1016/j.cca.2016.10.022 |
0.357 |
|
| 2016 |
Pottier C, Ravenscroft TA, Brown PH, Finch NA, Baker M, Parsons M, Asmann YW, Ren Y, Christopher E, Levitch D, van Blitterswijk M, Cruchaga C, Campion D, Nicolas G, Richard AC, ... ... Bu G, et al. TYROBP genetic variants in early-onset Alzheimer's disease. Neurobiology of Aging. PMID 27658901 DOI: 10.1016/J.Neurobiolaging.2016.07.028 |
0.4 |
|
| 2016 |
Kang SS, Kurti A, Wojtas A, Baker KE, Liu CC, Kanekiyo T, Deming Y, Cruchaga C, Estus S, Bu G, Fryer JD. Identification of Plexin A4 as a novel Clusterin receptor links two Alzheimer's disease risk genes. Human Molecular Genetics. PMID 27378688 DOI: 10.1093/Hmg/Ddw188 |
0.634 |
|
| 2016 |
Nicholson AM, Finch NA, Almeida M, Perkerson RB, van Blitterswijk M, Wojtas A, Cenik B, Rotondo S, Inskeep V, Almasy L, Dyer T, Peralta J, Jun G, Wood AR, Frayling TM, ... ... Bu G, et al. Prosaposin is a regulator of progranulin levels and oligomerization. Nature Communications. 7: 11992. PMID 27356620 DOI: 10.1038/Ncomms11992 |
0.365 |
|
| 2016 |
Yamazaki Y, Painter MM, Bu G, Kanekiyo T. Apolipoprotein E as a Therapeutic Target in Alzheimer's Disease: A Review of Basic Research and Clinical Evidence. Cns Drugs. PMID 27328687 DOI: 10.1007/s40263-016-0361-4 |
0.366 |
|
| 2016 |
Shinohara M, Murray ME, Frank RD, Shinohara M, DeTure M, Yamazaki Y, Tachibana M, Atagi Y, Davis MD, Liu CC, Zhao N, Painter MM, Petersen RC, Fryer JD, Crook JE, ... ... Bu G, et al. Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer's disease. Acta Neuropathologica. PMID 27179972 DOI: 10.1007/S00401-016-1580-Y |
0.64 |
|
| 2016 |
Fu Y, Zhao J, Atagi Y, Nielsen HM, Liu CC, Zheng H, Shinohara M, Kanekiyo T, Bu G. Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan. Molecular Neurodegeneration. 11: 37. PMID 27151330 DOI: 10.1186/S13024-016-0099-Y |
0.657 |
|
| 2016 |
Zheng H, Liu CC, Atagi Y, Chen XF, Jia L, Yang L, He W, Zhang X, Kang SS, Rosenberry TL, Fryer JD, Zhang YW, Xu H, Bu G. Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation. Neurobiology of Aging. 42: 132-41. PMID 27143430 DOI: 10.1016/J.Neurobiolaging.2016.03.004 |
0.598 |
|
| 2016 |
Zhang X, Hu J, Zhong L, Wang N, Yang L, Liu CC, Li H, Wang X, Zhou Y, Zhang Y, Xu H, Bu G, Zhuang J. Quercetin stabilizes apolipoprotein E and reduces brain Aβ levels in amyloid model mice. Neuropharmacology. PMID 27114256 DOI: 10.1016/J.Neuropharm.2016.04.032 |
0.641 |
|
| 2016 |
Yuede CM, Lee H, Restivo JL, Davis TA, Hettinger JC, Wallace CE, Young KL, Hayne MR, Bu G, Li CZ, Cirrito JR. Rapid in vivo measurement of β-amyloid reveals biphasic clearance kinetics in an Alzheimer's mouse model. The Journal of Experimental Medicine. PMID 27069115 DOI: 10.1084/Jem.20151428 |
0.472 |
|
| 2016 |
Sakae N, Liu CC, Shinohara M, Frisch-Daiello J, Ma L, Yamazaki Y, Tachibana M, Younkin L, Kurti A, Carrasquillo MM, Zou F, Sevlever D, Bisceglio G, Gan M, Fol R, ... ... Bu G, et al. ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 3848-59. PMID 27030769 DOI: 10.1523/Jneurosci.3757-15.2016 |
0.652 |
|
| 2016 |
Liu CC, Zhao N, Yamaguchi Y, Cirrito JR, Kanekiyo T, Holtzman DM, Bu G. Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer's disease. Science Translational Medicine. 8: 332ra44. PMID 27030596 DOI: 10.1126/Scitranslmed.Aad3650 |
0.613 |
|
| 2016 |
Li Y, Sun H, Chen Z, Xu H, Bu G, Zheng H. Implications of GABAergic Neurotransmission in Alzheimer's Disease. Frontiers in Aging Neuroscience. 8: 31. PMID 26941642 DOI: 10.3389/Fnagi.2016.00031 |
0.471 |
|
| 2016 |
Tai LM, Thomas R, Marottoli FM, Koster KP, Kanekiyo T, Morris AW, Bu G. The role of APOE in cerebrovascular dysfunction. Acta Neuropathologica. PMID 26884068 DOI: 10.1007/s00401-016-1547-z |
0.333 |
|
| 2016 |
Yamazaki Y, Baker DJ, Tachibana M, Liu CC, van Deursen JM, Brott TG, Bu G, Kanekiyo T. Vascular Cell Senescence Contributes to Blood-Brain Barrier Breakdown. Stroke; a Journal of Cerebral Circulation. PMID 26883501 DOI: 10.1161/Strokeaha.115.010835 |
0.539 |
|
| 2016 |
Reynolds MR, Singh I, Azad TD, Holmes BB, Verghese PB, Dietrich HH, Diamond M, Bu G, Han BH, Zipfel GJ. Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells. Molecular Neurodegeneration. 11: 9. PMID 26801396 DOI: 10.1186/S13024-016-0073-8 |
0.404 |
|
| 2016 |
Zheng H, Liu CC, Atagi Y, Chen XF, Jia L, Yang L, He W, Zhang X, Kang SS, Rosenberry TL, Fryer JD, Zhang YW, Xu H, Bu G. Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation Neurobiology of Aging. 42: 132-141. DOI: 10.1016/j.neurobiolaging.2016.03.004 |
0.598 |
|
| 2016 |
Shinohara M, Dickson DW, Bu G. P1-334: Regional Distribution of Amyloid-Beta, Soluble App and Synaptic Markers in Human Brains Alzheimer's & Dementia. 12: P556-P556. DOI: 10.1016/J.Jalz.2016.06.1085 |
0.343 |
|
| 2016 |
Kanekiyo T, Bu G. Apolipoprotein E and Amyloid-β-Independent Mechanisms in Alzheimer's Disease Genes, Environment and Alzheimer's Disease. 171-196. DOI: 10.1016/B978-0-12-802851-3.00006-1 |
0.408 |
|
| 2015 |
Tachibana M, Shinohara M, Yamazaki Y, Liu CC, Rogers J, Bu G, Kanekiyo T. Rescuing Effects of RXR Agonist Bexarotene on Aging-related Synapse Loss Depend on Neuronal LRP1. Experimental Neurology. PMID 26688581 DOI: 10.1016/j.expneurol.2015.12.003 |
0.536 |
|
| 2015 |
Chen XF, Wei Z, Wang T, Zhang ZL, Wang Y, Heckman MG, Diehl NN, Zhang YW, Xu H, Bu G. Demographic and Lifestyle Characteristics, but Not Apolipoprotein E Genotype, Are Associated with Intelligence among Young Chinese College Students. Plos One. 10: e0143157. PMID 26574747 DOI: 10.1371/Journal.Pone.0143157 |
0.309 |
|
| 2015 |
Malik M, Parikh I, Vasquez JB, Smith C, Tai L, Bu G, LaDu MJ, Fardo DW, Rebeck GW, Estus S. Genetics ignite focus on microglial inflammation in Alzheimer's disease. Molecular Neurodegeneration. 10: 52. PMID 26438529 DOI: 10.1186/S13024-015-0048-1 |
0.428 |
|
| 2015 |
Atagi Y, Liu CC, Painter MM, Chen XF, Verbeeck C, Zheng H, Li X, Rademakers R, Kang SS, Xu H, Younkin S, Das P, Fryer JD, Bu G. Apolipoprotein E is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2). The Journal of Biological Chemistry. PMID 26374899 DOI: 10.1074/Jbc.M115.679043 |
0.608 |
|
| 2015 |
Wren MC, Zhao J, Liu CC, Murray ME, Atagi Y, Davis MD, Fu Y, Okano HJ, Ogaki K, Strongosky AJ, Tacik P, Rademakers R, Ross OA, Dickson DW, Wszolek ZK, ... ... Bu G, et al. Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells. Molecular Neurodegeneration. 10: 46. PMID 26373282 DOI: 10.1186/S13024-015-0042-7 |
0.566 |
|
| 2015 |
Painter MM, Atagi Y, Liu CC, Rademakers R, Xu H, Fryer JD, Bu G. TREM2 in CNS homeostasis and neurodegenerative disease. Molecular Neurodegeneration. 10: 43. PMID 26337043 DOI: 10.1186/S13024-015-0040-9 |
0.584 |
|
| 2015 |
Zhao Y, Tseng IC, Heyser CJ, Rockenstein E, Mante M, Adame A, Zheng Q, Huang T, Wang X, Arslan PE, Chakrabarty P, Wu C, Bu G, Mobley WC, Zhang YW, et al. Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron. 87: 963-75. PMID 26335643 DOI: 10.1016/J.Neuron.2015.08.020 |
0.389 |
|
| 2015 |
Cook C, Kang SS, Carlomagno Y, Lin WL, Yue M, Kurti A, Shinohara M, Jansen-West K, Perkerson E, Castanedes-Casey M, Rousseau L, Phillips V, Bu G, Dickson DW, Petrucelli L, et al. Tau deposition drives neuropathological, inflammatory, and behavioral abnormalities independently of neuronal loss in a novel mouse model. Human Molecular Genetics. PMID 26276810 DOI: 10.1093/Hmg/Ddv336 |
0.393 |
|
| 2015 |
Feng T, Niu M, Ji C, Gao Y, Wen J, Bu G, Xu H, Zhang YW. SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation. Molecular Neurobiology. PMID 26115702 DOI: 10.1007/S12035-015-9306-Z |
0.381 |
|
| 2015 |
Harriott AM, Heckman MG, Rayaprolu S, Soto-Ortolaza AI, Diehl NN, Kanekiyo T, Liu CC, Bu G, Malik R, Cole JW, Meschia JF, Ross OA. Low density lipoprotein receptor related protein 1 and 6 gene variants and ischaemic stroke risk. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 22: 1235-41. PMID 26031789 DOI: 10.1111/Ene.12735 |
0.52 |
|
| 2015 |
Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, et al. Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nature Neuroscience. 18: 978-87. PMID 26005850 DOI: 10.1038/Nn.4025 |
0.476 |
|
| 2015 |
Casey CS, Atagi Y, Yamazaki Y, Shinohara M, Tachibana M, Fu Y, Bu G, Kanekiyo T. Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway. The Journal of Biological Chemistry. 290: 14208-17. PMID 25903128 DOI: 10.1074/jbc.M114.625251 |
0.382 |
|
| 2015 |
Hu J, Liu CC, Chen XF, Zhang YW, Xu H, Bu G. Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice. Molecular Neurodegeneration. 10: 6. PMID 25871773 DOI: 10.1186/S13024-015-0001-3 |
0.623 |
|
| 2015 |
Liu CC, Hu J, Tsai CW, Yue M, Melrose HL, Kanekiyo T, Bu G. Neuronal LRP1 regulates glucose metabolism and insulin signaling in the brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 5851-9. PMID 25855193 DOI: 10.1523/Jneurosci.5180-14.2015 |
0.595 |
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| 2015 |
DiBattista AM, Dumanis SB, Song JM, Bu G, Weeber E, William Rebeck G, Hoe HS. Very low density lipoprotein receptor regulates dendritic spine formation in a RasGRF1/CaMKII dependent manner. Biochimica Et Biophysica Acta. 1853: 904-17. PMID 25644714 DOI: 10.1016/J.Bbamcr.2015.01.015 |
0.332 |
|
| 2015 |
Hu J, Lin T, Gao Y, Xu J, Jiang C, Wang G, Bu G, Xu H, Chen H, Zhang YW. The resveratrol trimer miyabenol C inhibits β-secretase activity and β-amyloid generation. Plos One. 10: e0115973. PMID 25629409 DOI: 10.1371/Journal.Pone.0115973 |
0.421 |
|
| 2015 |
Hou P, Liu G, Zhao Y, Shi Z, Zheng Q, Bu G, Xu H, Zhang YW. The role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation. Neurobiology of Aging. 36: 1310-5. PMID 25557959 DOI: 10.1016/J.Neurobiolaging.2014.12.005 |
0.422 |
|
| 2014 |
Gan M, Jiang P, McLean P, Kanekiyo T, Bu G. Low-density lipoprotein receptor-related protein 1 (LRP1) regulates the stability and function of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor in neurons. Plos One. 9: e113237. PMID 25500815 DOI: 10.1371/Journal.Pone.0113237 |
0.365 |
|
| 2014 |
Wang X, Huang T, Zhao Y, Zheng Q, Thompson RC, Bu G, Zhang YW, Hong W, Xu H. Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity. Cell Reports. 9: 1023-33. PMID 25437557 DOI: 10.1016/J.Celrep.2014.09.037 |
0.477 |
|
| 2014 |
Chen Y, Peng Y, Che P, Gannon M, Liu Y, Li L, Bu G, van Groen T, Jiao K, Wang Q. α(2A) adrenergic receptor promotes amyloidogenesis through disrupting APP-SorLA interaction. Proceedings of the National Academy of Sciences of the United States of America. 111: 17296-301. PMID 25404298 DOI: 10.1073/Pnas.1409513111 |
0.414 |
|
| 2014 |
Liu CC, Tsai CW, Deak F, Rogers J, Penuliar M, Sung YM, Maher JN, Fu Y, Li X, Xu H, Estus S, Hoe HS, Fryer JD, Kanekiyo T, Bu G. Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease. Neuron. 84: 63-77. PMID 25242217 DOI: 10.1016/J.Neuron.2014.08.048 |
0.649 |
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| 2014 |
Wang X, Huang T, Bu G, Xu H. Dysregulation of protein trafficking in neurodegeneration. Molecular Neurodegeneration. 9: 31. PMID 25152012 DOI: 10.1186/1750-1326-9-31 |
0.372 |
|
| 2014 |
Liu CC, Kanekiyo T, Roth B, Bu G. Tyrosine-based signal mediates LRP6 receptor endocytosis and desensitization of Wnt/β-catenin pathway signaling. The Journal of Biological Chemistry. 289: 27562-70. PMID 25143377 DOI: 10.1074/Jbc.M113.533927 |
0.541 |
|
| 2014 |
Kanekiyo T, Bu G. The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer's disease. Frontiers in Aging Neuroscience. 6: 93. PMID 24904407 DOI: 10.3389/Fnagi.2014.00093 |
0.531 |
|
| 2014 |
Sotelo P, Farfán P, Benitez ML, Bu G, Marzolo MP. Sorting nexin 17 regulates ApoER2 recycling and reelin signaling. Plos One. 9: e93672. PMID 24705369 DOI: 10.1371/Journal.Pone.0093672 |
0.394 |
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| 2014 |
Martínez-Morillo E, Hansson O, Atagi Y, Bu G, Minthon L, Diamandis EP, Nielsen HM. Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer's disease patients and controls. Acta Neuropathologica. 127: 633-43. PMID 24633805 DOI: 10.1007/S00401-014-1266-2 |
0.443 |
|
| 2014 |
Shinohara M, Fujioka S, Murray ME, Wojtas A, Baker M, Rovelet-Lecrux A, Rademakers R, Das P, Parisi JE, Graff-Radford NR, Petersen RC, Dickson DW, Bu G. Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer's disease. Brain : a Journal of Neurology. 137: 1533-49. PMID 24625695 DOI: 10.1093/Brain/Awu046 |
0.45 |
|
| 2014 |
Medway CW, Abdul-Hay S, Mims T, Ma L, Bisceglio G, Zou F, Pankratz S, Sando SB, Aasly JO, Barcikowska M, Siuda J, Wszolek ZK, Ross OA, Carrasquillo M, Dickson DW, ... ... Bu G, et al. ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease. Molecular Neurodegeneration. 9: 11. PMID 24607147 DOI: 10.1186/1750-1326-9-11 |
0.327 |
|
| 2014 |
Zhao J, Fu Y, Liu CC, Shinohara M, Nielsen HM, Dong Q, Kanekiyo T, Bu G. Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway. The Journal of Biological Chemistry. 289: 11282-92. PMID 24599963 DOI: 10.1074/Jbc.M113.526095 |
0.598 |
|
| 2014 |
Jiang S, Li Y, Zhang C, Zhao Y, Bu G, Xu H, Zhang YW. M1 muscarinic acetylcholine receptor in Alzheimer's disease. Neuroscience Bulletin. 30: 295-307. PMID 24590577 DOI: 10.1007/S12264-013-1406-Z |
0.403 |
|
| 2014 |
Kanekiyo T, Xu H, Bu G. ApoE and Aβ in Alzheimer's disease: accidental encounters or partners? Neuron. 81: 740-54. PMID 24559670 DOI: 10.1016/J.Neuron.2014.01.045 |
0.504 |
|
| 2014 |
Jiang S, Li Y, Zhang X, Bu G, Xu H, Zhang YW. Trafficking regulation of proteins in Alzheimer's disease. Molecular Neurodegeneration. 9: 6. PMID 24410826 DOI: 10.1186/1750-1326-9-6 |
0.464 |
|
| 2014 |
Martínez-Morillo E, Nielsen HM, Batruch I, Drabovich AP, Begcevic I, Lopez MF, Minthon L, Bu G, Mattsson N, Portelius E, Hansson O, Diamandis EP. Assessment of peptide chemical modifications on the development of an accurate and precise multiplex selected reaction monitoring assay for apolipoprotein e isoforms. Journal of Proteome Research. 13: 1077-87. PMID 24392642 DOI: 10.1021/Pr401060X |
0.347 |
|
| 2014 |
Tai LM, Mehra S, Shete V, Estus S, Rebeck GW, Bu G, LaDu MJ. Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk. Molecular Neurodegeneration. 9: 2. PMID 24386905 DOI: 10.1186/1750-1326-9-2 |
0.467 |
|
| 2013 |
Kanekiyo T, Cirrito JR, Liu CC, Shinohara M, Li J, Schuler DR, Shinohara M, Holtzman DM, Bu G. Neuronal clearance of amyloid-β by endocytic receptor LRP1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 19276-83. PMID 24305823 DOI: 10.1523/Jneurosci.3487-13.2013 |
0.65 |
|
| 2013 |
Chen XF, Zhang YW, Xu H, Bu G. Transcriptional regulation and its misregulation in Alzheimer's disease. Molecular Brain. 6: 44. PMID 24144318 DOI: 10.1186/1756-6606-6-44 |
0.451 |
|
| 2013 |
Wolf AB, Valla J, Bu G, Kim J, LaDu MJ, Reiman EM, Caselli RJ. Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease. Alzheimer's Research & Therapy. 5: 38. PMID 23998393 DOI: 10.1186/Alzrt204 |
0.601 |
|
| 2013 |
Li X, Liu Y, Zheng Q, Yao G, Cheng P, Bu G, Xu H, Zhang YW. Ferritin light chain interacts with PEN-2 and affects γ-secretase activity. Neuroscience Letters. 548: 90-4. PMID 23685131 DOI: 10.1016/J.Neulet.2013.05.018 |
0.387 |
|
| 2013 |
Verghese PB, Castellano JM, Garai K, Wang Y, Jiang H, Shah A, Bu G, Frieden C, Holtzman DM. ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions. Proceedings of the National Academy of Sciences of the United States of America. 110: E1807-16. PMID 23620513 DOI: 10.1073/Pnas.1220484110 |
0.496 |
|
| 2013 |
Farfán P, Lee J, Larios J, Sotelo P, Bu G, Marzolo MP. A sorting nexin 17-binding domain within the LRP1 cytoplasmic tail mediates receptor recycling through the basolateral sorting endosome. Traffic (Copenhagen, Denmark). 14: 823-38. PMID 23593972 DOI: 10.1111/Tra.12076 |
0.348 |
|
| 2013 |
Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, et al. Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nature Medicine. 19: 473-80. PMID 23524343 DOI: 10.1038/Nm.3117 |
0.355 |
|
| 2013 |
Shinohara M, Petersen RC, Dickson DW, Bu G. Brain regional correlation of amyloid-β with synapses and apolipoprotein E in non-demented individuals: potential mechanisms underlying regional vulnerability to amyloid-β accumulation. Acta Neuropathologica. 125: 535-47. PMID 23371365 DOI: 10.1007/S00401-013-1086-9 |
0.442 |
|
| 2013 |
Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nature Reviews. Neurology. 9: 106-18. PMID 23296339 DOI: 10.1038/Nrneurol.2012.263 |
0.643 |
|
| 2013 |
Tai LM, Bilousova T, Jungbauer L, Roeske SK, Youmans KL, Yu C, Poon WW, Cornwell LB, Miller CA, Vinters HV, Van Eldik LJ, Fardo DW, Estus S, Bu G, Gylys KH, et al. Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples. The Journal of Biological Chemistry. 288: 5914-26. PMID 23293020 DOI: 10.1074/Jbc.M112.442103 |
0.46 |
|
| 2013 |
Shinohara M, Bu G. What can we learn from regional vulnerability to amyloid-β accumulation in nondemented individuals? Neurodegenerative Disease Management. 3: 187-189. DOI: 10.2217/Nmt.13.20 |
0.38 |
|
| 2013 |
N’Songo A, Kanekiyo T, Bu G. LRP1 plays a major role in the amyloid-β clearance in microglia Molecular Neurodegeneration. 8. DOI: 10.1186/1750-1326-8-S1-P33 |
0.516 |
|
| 2013 |
Bu G, Liu C, Kanekiyo T. Vascular hypothesis of Alzheimer’s disease: role of apoE and apoE receptors Molecular Neurodegeneration. 8. DOI: 10.1186/1750-1326-8-S1-O20 |
0.649 |
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| 2013 |
Liu CC, Kanekiyo T, Xu H, Bu G. Erratum: Apolipoprotein e and Alzheimer disease: Risk, mechanisms and therapy (Nature Reviews Neurology (2013) 9 (106-118)) Nature Reviews Neurology. 9. DOI: 10.1038/Nrneurol2013.32 |
0.335 |
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| 2013 |
Bu G. S1-01-01: APOE and APOE receptors in brain lipid metabolism, synaptic functions and clearance of beta-amyloid Alzheimer's & Dementia. 9: P121-P121. DOI: 10.1016/J.Jalz.2013.04.032 |
0.43 |
|
| 2012 |
Kanekiyo T, Liu CC, Shinohara M, Li J, Bu G. LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 16458-65. PMID 23152628 DOI: 10.1523/Jneurosci.3987-12.2012 |
0.634 |
|
| 2012 |
Li J, Kanekiyo T, Shinohara M, Zhang Y, LaDu MJ, Xu H, Bu G. Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms. The Journal of Biological Chemistry. 287: 44593-601. PMID 23132858 DOI: 10.1074/Jbc.M112.420224 |
0.469 |
|
| 2012 |
Zhang H, Zhang YW, Chen Y, Huang X, Zhou F, Wang W, Xian B, Zhang X, Masliah E, Chen Q, Han JD, Bu G, Reed JC, Liao FF, Chen YG, et al. Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15565-76. PMID 23115192 DOI: 10.1523/Jneurosci.3668-12.2012 |
0.342 |
|
| 2012 |
Youmans KL, Tai LM, Nwabuisi-Heath E, Jungbauer L, Kanekiyo T, Gan M, Kim J, Eimer WA, Estus S, Rebeck GW, Weeber EJ, Bu G, Yu C, Ladu MJ. APOE4-specific changes in Aβ accumulation in a new transgenic mouse model of Alzheimer disease. The Journal of Biological Chemistry. 287: 41774-86. PMID 23060451 DOI: 10.1074/Jbc.M112.407957 |
0.65 |
|
| 2012 |
Chen Y, Huang X, Zhang YW, Rockenstein E, Bu G, Golde TE, Masliah E, Xu H. Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11390-5. PMID 22895721 DOI: 10.1523/Jneurosci.0757-12.2012 |
0.458 |
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| 2012 |
Youmans KL, Tai LM, Kanekiyo T, Stine WB, Michon SC, Nwabuisi-Heath E, Manelli AM, Fu Y, Riordan S, Eimer WA, Binder L, Bu G, Yu C, Hartley DM, LaDu MJ. Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody. Molecular Neurodegeneration. 7: 8. PMID 22423893 DOI: 10.1186/1750-1326-7-8 |
0.396 |
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| 2012 |
Holtzman DM, Herz J, Bu G. Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 2: a006312. PMID 22393530 DOI: 10.1101/Cshperspect.A006312 |
0.522 |
|
| 2012 |
Liu C, Hoe H, Bu G. Wnt signaling receptor LRP6 interacts with amyloid precursor protein and regulates its trafficking and processing Molecular Neurodegeneration. 7: O5. DOI: 10.1186/1750-1326-7-S1-O5 |
0.664 |
|
| 2012 |
Bu G. ApoE and apoE receptors in brain lipid metabolism and AD Molecular Neurodegeneration. 7: L10. DOI: 10.1186/1750-1326-7-S1-L10 |
0.459 |
|
| 2012 |
Shinohara M, Dickson D, Bu G. P4-078: Brain regional distribution of apolipoprotein E and beta-amyloid peptides in cognitively normal persons Alzheimer's & Dementia. 8: P660-P661. DOI: 10.1016/J.Jalz.2012.05.1780 |
0.329 |
|
| 2011 |
Chen J, Liu CC, Li Q, Nowak C, Bu G, Wang J. Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6. Structure (London, England : 1993). 19: 313-23. PMID 21397183 DOI: 10.1016/J.Str.2011.01.010 |
0.512 |
|
| 2011 |
Kanekiyo T, Zhang J, Liu Q, Liu CC, Zhang L, Bu G. Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 1644-51. PMID 21289173 DOI: 10.1523/Jneurosci.5491-10.2011 |
0.642 |
|
| 2011 |
Liu Q, Zhang J, Zerbinatti C, Zhan Y, Kolber BJ, Herz J, Muglia LJ, Bu G. Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. Plos Biology. 9: e1000575. PMID 21264353 DOI: 10.1371/Journal.Pbio.1000575 |
0.315 |
|
| 2011 |
Youmans KL, Leung S, Zhang J, Maus E, Baysac K, Bu G, Vassar R, Yu C, LaDu MJ. Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations. Journal of Neuroscience Methods. 196: 51-9. PMID 21219931 DOI: 10.1016/J.Jneumeth.2010.12.025 |
0.443 |
|
| 2011 |
Sakamoto K, Bu G, Chen S, Takei Y, Hibi K, Kodera Y, McCormick LM, Nakao A, Noda M, Muramatsu T, Kadomatsu K. Premature ligand-receptor interaction during biosynthesis limits the production of growth factor midkine and its receptor LDL receptor-related protein 1. The Journal of Biological Chemistry. 286: 8405-13. PMID 21212259 DOI: 10.1074/Jbc.M110.176479 |
0.358 |
|
| 2010 |
Liu Q, Trotter J, Zhang J, Peters MM, Cheng H, Bao J, Han X, Weeber EJ, Bu G. Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 17068-78. PMID 21159977 DOI: 10.1523/Jneurosci.4067-10.2010 |
0.468 |
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| 2010 |
Owen JB, Sultana R, Aluise CD, Erickson MA, Price TO, Bu G, Banks WA, Butterfield DA. Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: implications for Aβ accumulation in AD brain. Free Radical Biology & Medicine. 49: 1798-803. PMID 20869432 DOI: 10.1016/J.Freeradbiomed.2010.09.013 |
0.363 |
|
| 2010 |
Fuentealba RA, Liu Q, Zhang J, Kanekiyo T, Hu X, Lee JM, LaDu MJ, Bu G. Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking. Plos One. 5: e11884. PMID 20686698 DOI: 10.1371/Journal.Pone.0011884 |
0.432 |
|
| 2010 |
Li Y, Lu W, King TD, Liu CC, Bijur GN, Bu G. Dkk1 stabilizes Wnt co-receptor LRP6: implication for Wnt ligand-induced LRP6 down-regulation. Plos One. 5: e11014. PMID 20543981 DOI: 10.1371/Journal.Pone.0011014 |
0.565 |
|
| 2010 |
Chen J, Li Q, Liu CC, Zhou P, Zhou B, Bu G, Wang J. NMR structure note: solution structure of the core domain of MESD that is essential for proper folding of LRP5/6. Journal of Biomolecular Nmr. 47: 283-8. PMID 20506034 DOI: 10.1007/s10858-010-9426-8 |
0.389 |
|
| 2010 |
Lu W, Liu CC, Thottassery JV, Bu G, Li Y. Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells. Biochemistry. 49: 4635-43. PMID 20446724 DOI: 10.1021/Bi1001486 |
0.546 |
|
| 2010 |
Liu CC, Prior J, Piwnica-Worms D, Bu G. LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy. Proceedings of the National Academy of Sciences of the United States of America. 107: 5136-41. PMID 20194742 DOI: 10.1073/Pnas.0911220107 |
0.485 |
|
| 2009 |
Hu X, Crick SL, Bu G, Frieden C, Pappu RV, Lee JM. Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide Proceedings of the National Academy of Sciences of the United States of America. 106: 20324-20329. PMID 19910533 DOI: 10.1073/Pnas.0911281106 |
0.408 |
|
| 2009 |
Grear KE, Ling IF, Simpson JF, Furman JL, Simmons CR, Peterson SL, Schmitt FA, Markesbery WR, Liu Q, Crook JE, Younkin SG, Bu G, Estus S. Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain. Molecular Neurodegeneration. 4: 46. PMID 19889229 DOI: 10.1186/1750-1326-4-46 |
0.433 |
|
| 2009 |
Kanekiyo T, Bu G. Receptor-associated protein interacts with amyloid-beta peptide and promotes its cellular uptake. The Journal of Biological Chemistry. 284: 33352-9. PMID 19826010 DOI: 10.1074/Jbc.M109.015032 |
0.481 |
|
| 2009 |
Fuentealba RA, Liu Q, Kanekiyo T, Zhang J, Bu G. Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway. The Journal of Biological Chemistry. 284: 34045-53. PMID 19815552 DOI: 10.1074/Jbc.M109.021030 |
0.394 |
|
| 2009 |
Song H, Bu G. MicroRNA-205 inhibits tumor cell migration through down-regulating the expression of the LDL receptor-related protein 1. Biochemical and Biophysical Research Communications. 388: 400-5. PMID 19665999 DOI: 10.1016/J.Bbrc.2009.08.020 |
0.337 |
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| 2009 |
Hoe HS, Lee KJ, Carney RS, Lee J, Markova A, Lee JY, Howell BW, Hyman BT, Pak DT, Bu G, Rebeck GW. Interaction of reelin with amyloid precursor protein promotes neurite outgrowth. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 7459-73. PMID 19515914 DOI: 10.1523/Jneurosci.4872-08.2009 |
0.439 |
|
| 2009 |
Liu Q, Zhang J, Tran H, Verbeek MM, Reiss K, Estus S, Bu G. LRP1 shedding in human brain: roles of ADAM10 and ADAM17. Molecular Neurodegeneration. 4: 17. PMID 19371428 DOI: 10.1186/1750-1326-4-17 |
0.433 |
|
| 2009 |
Bu G. Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy. Nature Reviews. Neuroscience. 10: 333-44. PMID 19339974 DOI: 10.1038/Nrn2620 |
0.51 |
|
| 2009 |
Liu CC, Pearson C, Bu G. Cooperative folding and ligand-binding properties of LRP6 beta-propeller domains. The Journal of Biological Chemistry. 284: 15299-307. PMID 19339249 DOI: 10.1074/jbc.M807285200 |
0.478 |
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| 2009 |
Marzolo MP, Bu G. Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease. Seminars in Cell & Developmental Biology. 20: 191-200. PMID 19041409 DOI: 10.1016/J.Semcdb.2008.10.005 |
0.49 |
|
| 2009 |
Kanekiyo T, Bu G. LRP1 and cerebral amyloid angiopathy Future Neurology. 4: 55-65. DOI: 10.2217/14796708.4.1.55 |
0.486 |
|
| 2008 |
Knisely JM, Lee J, Bu G. Measurement of receptor endocytosis and recycling. Methods in Molecular Biology (Clifton, N.J.). 457: 319-32. PMID 19066038 DOI: 10.1007/978-1-59745-261-8_24 |
0.774 |
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| 2008 |
Doray B, Knisely JM, Wartman L, Bu G, Kornfeld S. Identification of acidic dileucine signals in LRP9 that interact with both GGAs and AP-1/AP-2. Traffic (Copenhagen, Denmark). 9: 1551-62. PMID 18627575 DOI: 10.1111/J.1600-0854.2008.00786.X |
0.753 |
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| 2008 |
Bu G, Lu W, Liu CC, Selander K, Yoneda T, Hall C, Keller ET, Li Y. Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: implication for breast cancer osteolytic bone metastases. International Journal of Cancer. Journal International Du Cancer. 123: 1034-42. PMID 18546262 DOI: 10.1002/Ijc.23625 |
0.418 |
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| 2008 |
Cirrito JR, Kang JE, Lee J, Stewart FR, Verges DK, Silverio LM, Bu G, Mennerick S, Holtzman DM. Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo. Neuron. 58: 42-51. PMID 18400162 DOI: 10.1016/J.Neuron.2008.02.003 |
0.422 |
|
| 2008 |
Parkyn CJ, Vermeulen EG, Mootoosamy RC, Sunyach C, Jacobsen C, Oxvig C, Moestrup S, Liu Q, Bu G, Jen A, Morris RJ. LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein. Journal of Cell Science. 121: 773-83. PMID 18285446 DOI: 10.1242/Jcs.021816 |
0.336 |
|
| 2008 |
Lee J, Retamal C, Cuitiño L, Caruano-Yzermans A, Shin JE, van Kerkhof P, Marzolo MP, Bu G. Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes. The Journal of Biological Chemistry. 283: 11501-8. PMID 18276590 DOI: 10.1074/jbc.M800642200 |
0.32 |
|
| 2008 |
Bu G. S3-02-01: Role of LRP in APOE and Abeta metabloism Alzheimer's & Dementia. 4: T151-T151. DOI: 10.1016/J.Jalz.2008.05.378 |
0.39 |
|
| 2008 |
Fuentealba RA, Bu G. P4-246: Low density lipoprotein receptor-related protein 1 (LRP1) mediates anti-apoptotic signaling in primary neurons Alzheimer's & Dementia. 4: T743-T744. DOI: 10.1016/J.Jalz.2008.05.2314 |
0.324 |
|
| 2007 |
Wilhelmus MM, Otte-Höller I, van Triel JJ, Veerhuis R, Maat-Schieman ML, Bu G, de Waal RM, Verbeek MM. Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells. The American Journal of Pathology. 171: 1989-99. PMID 18055545 DOI: 10.2353/Ajpath.2007.070050 |
0.383 |
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| 2007 |
Liu Q, Zerbinatti CV, Zhang J, Hoe HS, Wang B, Cole SL, Herz J, Muglia L, Bu G. Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron. 56: 66-78. PMID 17920016 DOI: 10.1016/J.Neuron.2007.08.008 |
0.524 |
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| 2007 |
Knisely JM, Li Y, Griffith JM, Geuze HJ, Schwartz AL, Bu G. Slow endocytosis of the LDL receptor-related protein 1B: implications for a novel cytoplasmic tail conformation. Experimental Cell Research. 313: 3298-307. PMID 17658514 DOI: 10.1016/J.Yexcr.2007.05.026 |
0.769 |
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| 2007 |
Fuentealba RA, Barría MI, Lee J, Cam J, Araya C, Escudero CA, Inestrosa NC, Bronfman FC, Bu G, Marzolo MP. ApoER2 expression increases Abeta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity. Molecular Neurodegeneration. 2: 14. PMID 17620134 DOI: 10.1186/1750-1326-2-14 |
0.809 |
|
| 2007 |
Yuseff MI, Farfan P, Bu G, Marzolo MP. A cytoplasmic PPPSP motif determines megalin's phosphorylation and regulates receptor's recycling and surface expression. Traffic (Copenhagen, Denmark). 8: 1215-30. PMID 17555532 DOI: 10.1111/J.1600-0854.2007.00601.X |
0.331 |
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| 2007 |
Doray B, Lee I, Knisely J, Bu G, Kornfeld S. The gamma/sigma1 and alpha/sigma2 hemicomplexes of clathrin adaptors AP-1 and AP-2 harbor the dileucine recognition site. Molecular Biology of the Cell. 18: 1887-96. PMID 17360967 DOI: 10.1091/Mbc.E07-01-0012 |
0.749 |
|
| 2006 |
Bu G, Cam J, Zerbinatti C. LRP in amyloid-beta production and metabolism. Annals of the New York Academy of Sciences. 1086: 35-53. PMID 17185504 DOI: 10.1196/Annals.1377.005 |
0.819 |
|
| 2006 |
Rebeck GW, LaDu MJ, Estus S, Bu G, Weeber EJ. The generation and function of soluble apoE receptors in the CNS. Molecular Neurodegeneration. 1: 15. PMID 17062143 DOI: 10.1186/1750-1326-1-15 |
0.362 |
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| 2006 |
Zerbinatti CV, Wahrle SE, Kim H, Cam JA, Bales K, Paul SM, Holtzman DM, Bu G. Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice. The Journal of Biological Chemistry. 281: 36180-6. PMID 17012232 DOI: 10.1074/Jbc.M604436200 |
0.816 |
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| 2006 |
Cam JA, Bu G. Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family. Molecular Neurodegeneration. 1: 8. PMID 16930455 DOI: 10.1186/1750-1326-1-8 |
0.817 |
|
| 2006 |
Knisely JM, Bu G. Genetics and molecular biology: motive studies in mice--two NPXY motifs in the intracellular domain of lipoprotein receptor-related protein 1 exhibit differential importance during fetal development. Current Opinion in Lipidology. 17: 480-2. PMID 16832172 DOI: 10.1097/01.Mol.0000236374.80872.23 |
0.763 |
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| 2006 |
LaDu MJ, Stine WB, Narita M, Getz GS, Reardon CA, Bu G. Self-assembly of HEK cell-secreted ApoE particles resembles ApoE enrichment of lipoproteins as a ligand for the LDL receptor-related protein. Biochemistry. 45: 381-90. PMID 16401069 DOI: 10.1021/Bi051765S |
0.442 |
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| 2006 |
Chen X, Zhong L, Wang T, Wang Z, Bu G. O4-02-01: SOLUBLE TREM2 MODULATES MICROGLIAL FUNCTION AND PROTECTS AGAINST AMYLOID PATHOLOGY Alzheimer's & Dementia. 14: P1402-P1402. DOI: 10.1016/J.Jalz.2018.06.2915 |
0.33 |
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| 2006 |
Bu G. PL-04-01: PATHOBIOLOGY OF APOE IN ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P1399-P1399. DOI: 10.1016/J.Jalz.2018.06.2905 |
0.403 |
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| 2006 |
Yamazaki Y, Liu C, Oue H, Kurti A, Yamazaki A, Fryer JD, Kanekiyo T, Bu G. P4-065: APOE4 CONDITIONALLY EXPRESSED IN CEREBROVASCULATURE IMPAIRS ENDOTHELIAL FUNCTIONS AND INDUCES COGNITIVE DEFICITS Alzheimer's & Dementia. 14: P1457-P1458. DOI: 10.1016/J.Jalz.2018.06.2468 |
0.502 |
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| 2006 |
Yamada K, Yabuki C, Tachikawa M, Ohtsuki S, Strickland DK, Bu G, Terasaki T, Hashimoto T, Iwatsubo T. AbstractPoster presentation: Wednesday posterP4-069: Modeling amyloid β-peptide transport across the blood-brain barrier in TR-BBB cells Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1807 |
0.325 |
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| 2006 |
Verbeek MM, Wilhelmus MM, Otte-Holler I, Bu G, Maat-Schieman ML, Veerhuis R, Kuesters B, de Waal RM. P4-035: Amyloid β protein receptors in Alzheimer's disease Alzheimer's & Dementia. 2: S523-S523. DOI: 10.1016/J.Jalz.2006.05.1773 |
0.421 |
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| 2006 |
Marzolo M, Fuentealba R, Inestrosa NC, Bu G. P3-429: ApoER2 modulates APP trafficking and regulates secreted abeta levels Alzheimer's & Dementia. 2: S502-S502. DOI: 10.1016/J.Jalz.2006.05.1700 |
0.336 |
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| 2005 |
Li Y, Chen J, Lu W, McCormick LM, Wang J, Bu G. Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding. Journal of Cell Science. 118: 5305-14. PMID 16263759 DOI: 10.1242/Jcs.02651 |
0.343 |
|
| 2005 |
Cuitino L, Matute R, Retamal C, Bu G, Inestrosa NC, Marzolo MP. ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its Rafts' association. Traffic (Copenhagen, Denmark). 6: 820-38. PMID 16101684 DOI: 10.1111/J.1600-0854.2005.00320.X |
0.399 |
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| 2005 |
Pastrana DV, Hanson AJ, Knisely J, Bu G, Fitzgerald DJ. LRP 1 B functions as a receptor for Pseudomonas exotoxin. Biochimica Et Biophysica Acta. 1741: 234-9. PMID 16095885 DOI: 10.1016/J.Bbadis.2005.06.007 |
0.758 |
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| 2005 |
van Kerkhof P, Lee J, McCormick L, Tetrault E, Lu W, Schoenfish M, Oorschot V, Strous GJ, Klumperman J, Bu G. Sorting nexin 17 facilitates LRP recycling in the early endosome. The Embo Journal. 24: 2851-61. PMID 16052210 DOI: 10.1038/Sj.Emboj.7600756 |
0.351 |
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| 2005 |
Li Y, Lu W, Bu G. Striking differences of LDL receptor-related protein 1B expression in mouse and human. Biochemical and Biophysical Research Communications. 333: 868-73. PMID 15963947 DOI: 10.1016/J.Bbrc.2005.05.170 |
0.329 |
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| 2005 |
Zerbinatti CV, Bu G. LRP and Alzheimer's disease Reviews in the Neurosciences. 16: 123-135. PMID 15959937 DOI: 10.1515/Revneuro.2005.16.2.123 |
0.554 |
|
| 2005 |
Fryer JD, Demattos RB, McCormick LM, O'Dell MA, Spinner ML, Bales KR, Paul SM, Sullivan PM, Parsadanian M, Bu G, Holtzman DM. The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice. The Journal of Biological Chemistry. 280: 25754-9. PMID 15888448 DOI: 10.1074/Jbc.M502143200 |
0.509 |
|
| 2005 |
McCormick LM, Urade R, Arakaki Y, Schwartz AL, Bu G. Independent and cooperative roles of N-glycans and molecular chaperones in the folding and disulfide bond formation of the low-density lipoprotein (LDL) receptor-related protein. Biochemistry. 44: 5794-803. PMID 15823038 DOI: 10.1021/Bi047652A |
0.335 |
|
| 2005 |
Green PS, Bales K, Paul S, Bu G. Estrogen therapy fails to alter amyloid deposition in the PDAPP model of Alzheimer's disease Endocrinology. 146: 2774-2781. PMID 15731362 DOI: 10.1210/En.2004-1433 |
0.454 |
|
| 2005 |
Cam JA, Zerbinatti CV, Li Y, Bu G. Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the beta-amyloid precursor protein. The Journal of Biological Chemistry. 280: 15464-70. PMID 15705569 DOI: 10.1074/Jbc.M500613200 |
0.819 |
|
| 2004 |
Li Y, Lu W, He X, Schwartz AL, Bu G. LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering beta-catenin subcellular distribution. Oncogene. 23: 9129-35. PMID 15516984 DOI: 10.1038/Sj.Onc.1208123 |
0.355 |
|
| 2004 |
Pan W, Kastin AJ, Zankel TC, van Kerkhof P, Terasaki T, Bu G. Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier. Journal of Cell Science. 117: 5071-8. PMID 15383619 DOI: 10.1242/Jcs.01381 |
0.369 |
|
| 2004 |
Prince WS, McCormick LM, Wendt DJ, Fitzpatrick PA, Schwartz KL, Aguilera AI, Koppaka V, Christianson TM, Vellard MC, Pavloff N, Lemontt JF, Qin M, Starr CM, Bu G, Zankel TC. Lipoprotein receptor binding, cellular uptake, and lysosomal delivery of fusions between the receptor-associated protein (RAP) and alpha-L-iduronidase or acid alpha-glucosidase. The Journal of Biological Chemistry. 279: 35037-46. PMID 15170390 DOI: 10.1074/Jbc.M402630200 |
0.344 |
|
| 2004 |
Cam JA, Zerbinatti CV, Knisely JM, Hecimovic S, Li Y, Bu G. The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production. The Journal of Biological Chemistry. 279: 29639-46. PMID 15126508 DOI: 10.1074/Jbc.M313893200 |
0.816 |
|
| 2004 |
Zerbinatti CV, Wozniak DF, Cirrito J, Cam JA, Osaka H, Bales KR, Zhuo M, Paul SM, Holtzman DM, Bu G. Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein. Proceedings of the National Academy of Sciences of the United States of America. 101: 1075-80. PMID 14732699 DOI: 10.1073/Pnas.0305803101 |
0.814 |
|
| 2004 |
Zerbinatti CV, Bales KR, Paul SM, Bu G. P2-116 Neuronal overexpression of LRP selectively increases a detergent-soluble pool of hippocampal abeta in PDAPP mice Neurobiology of Aging. 25: S257. DOI: 10.1016/S0197-4580(04)80863-7 |
0.323 |
|
| 2004 |
Fryer JD, DeMattos RB, O'Dell MA, Spinner ML, Bales KR, Paul SM, Parsadanian M, Bu G, Holtzman DM. O1-03-04 The LDL receptor regulates levels of CNS and Alzheimer's disease-like pathology Neurobiology of Aging. 25: S14-S15. DOI: 10.1016/S0197-4580(04)80047-2 |
0.403 |
|
| 2003 |
Li Y, Lu W, Bu G. Essential role of the low density lipoprotein receptor-related protein in vascular smooth muscle cell migration. Febs Letters. 555: 346-50. PMID 14644440 DOI: 10.1016/S0014-5793(03)01272-9 |
0.314 |
|
| 2003 |
Knisely JM, Bu G. Genetics and molecular biology. Current Opinion in Lipidology. 14: 401-3. PMID 12865740 DOI: 10.1097/00041433-200308000-00012 |
0.73 |
|
| 2003 |
Marzolo MP, Yuseff MI, Retamal C, Donoso M, Ezquer F, Farfán P, Li Y, Bu G. Differential distribution of low-density lipoprotein-receptor-related protein (LRP) and megalin in polarized epithelial cells is determined by their cytoplasmic domains. Traffic (Copenhagen, Denmark). 4: 273-88. PMID 12694565 DOI: 10.1034/J.1600-0854.2003.00081.X |
0.329 |
|
| 2002 |
Narita M, Holtzman DM, Fagan AM, LaDu MJ, Yu L, Han X, Gross RW, Bu G, Schwartz AL. Cellular catabolism of lipid poor apolipoprotein E via cell surface LDL receptor-related protein. Journal of Biochemistry. 132: 743-9. PMID 12417024 DOI: 10.1093/oxfordjournals.jbchem.a003282 |
0.333 |
|
| 2002 |
Melman L, Geuze HJ, Li Y, McCormick LM, Van Kerkhof P, Strous GJ, Schwartz AL, Bu G. Proteasome regulates the delivery of LDL receptor-related protein into the degradation pathway. Molecular Biology of the Cell. 13: 3325-35. PMID 12221136 DOI: 10.1091/Mbc.E02-03-0152 |
0.375 |
|
| 2002 |
Shibata Y, Muramatsu T, Hirai M, Inui T, Kimura T, Saito H, McCormick LM, Bu G, Kadomatsu K. Nuclear targeting by the growth factor midkine. Molecular and Cellular Biology. 22: 6788-96. PMID 12215536 DOI: 10.1128/Mcb.22.19.6788-6796.2002 |
0.334 |
|
| 2002 |
Li Y, Knisely JM, Lu W, McCormick LM, Wang J, Henkin J, Schwartz AL, Bu G. Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration. The Journal of Biological Chemistry. 277: 42366-71. PMID 12194987 DOI: 10.1074/Jbc.M207705200 |
0.778 |
|
| 2002 |
Gent J, van Kerkhof P, Roza M, Bu G, Strous GJ. Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis. Proceedings of the National Academy of Sciences of the United States of America. 99: 9858-63. PMID 12105275 DOI: 10.1073/Pnas.152294299 |
0.327 |
|
| 2002 |
Li Y, Lu W, Schwartz AL, Bu G. Receptor-associated protein facilitates proper folding and maturation of the low-density lipoprotein receptor and its class 2 mutants. Biochemistry. 41: 4921-8. PMID 11939787 DOI: 10.1021/Bi011894I |
0.363 |
|
| 2002 |
Su HP, Nakada-Tsukui K, Tosello-Trampont AC, Li Y, Bu G, Henson PM, Ravichandran KS. Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). The Journal of Biological Chemistry. 277: 11772-9. PMID 11729193 DOI: 10.1074/Jbc.M109336200 |
0.338 |
|
| 2001 |
Li Y, Cam J, Bu G. Low-density lipoprotein receptor family: Endocytosis and signal transduction Molecular Neurobiology. 23: 53-67. PMID 11642543 DOI: 10.1385/Mn:23:1:53 |
0.785 |
|
| 2001 |
LaDu MJ, Shah JA, Reardon CA, Getz GS, Bu G, Hu J, Guo L, Van Eldik LJ. Apolipoprotein E and apolipoprotein E receptors modulate A beta-induced glial neuroinflammatory responses. Neurochemistry International. 39: 427-34. PMID 11578778 DOI: 10.1016/S0197-0186(01)00050-X |
0.411 |
|
| 2001 |
van Kerkhof P, Alves dos Santos CM, Sachse M, Klumperman J, Bu G, Strous GJ. Proteasome inhibitors block a late step in lysosomal transport of selected membrane but not soluble proteins. Molecular Biology of the Cell. 12: 2556-66. PMID 11514635 DOI: 10.1091/Mbc.12.8.2556 |
0.314 |
|
| 2001 |
Liu CX, Li Y, Obermoeller-McCormick LM, Schwartz AL, Bu G. The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein. The Journal of Biological Chemistry. 276: 28889-96. PMID 11384978 DOI: 10.1074/jbc.M102727200 |
0.518 |
|
| 2001 |
Melman L, Cao ZF, Rennke S, Marzolo MP, Wardell MR, Bu G. High affinity binding of receptor-associated protein to heparin and low density lipoprotein receptor-related protein requires similar basic amino acid sequence motifs. The Journal of Biological Chemistry. 276: 29338-46. PMID 11382778 DOI: 10.1074/Jbc.M103717200 |
0.306 |
|
| 2001 |
Li Y, Lu W, Marzolo MP, Bu G. Differential Functions of Members of the Low Density Lipoprotein Receptor Family Suggested by their Distinct Endocytosis Rates Journal of Biological Chemistry. 276: 18000-18006. PMID 11279214 DOI: 10.1074/Jbc.M101589200 |
0.36 |
|
| 2001 |
Li Y, van Kerkhof P, Marzolo MP, Strous GJ, Bu G. Identification of a major cyclic AMP-dependent protein kinase A phosphorylation site within the cytoplasmic tail of the low-density lipoprotein receptor-related protein: implication for receptor-mediated endocytosis. Molecular and Cellular Biology. 21: 1185-95. PMID 11158305 DOI: 10.1128/Mcb.21.4.1185-1195.2001 |
0.345 |
|
| 2000 |
Bu G, Marzolo MP. Role of RAP in the biogenesis of lipoprotein receptors Trends in Cardiovascular Medicine. 10: 148-155. PMID 11239794 DOI: 10.1016/S1050-1738(00)00045-1 |
0.355 |
|
| 2000 |
Liu Y, Jones M, Hingtgen CM, Bu G, Laribee N, Tanzi RE, Moir RD, Nath A, He JJ. Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Nature Medicine. 6: 1380-7. PMID 11100124 DOI: 10.1038/82199 |
0.352 |
|
| 2000 |
LaDu MJ, Shah JA, Reardon CA, Getz GS, Bu G, Hu J, Guo L, van Eldik LJ. Apolipoprotein E receptors mediate the effects of beta-amyloid on astrocyte cultures. The Journal of Biological Chemistry. 275: 33974-80. PMID 10940295 DOI: 10.1074/Jbc.M000602200 |
0.456 |
|
| 2000 |
Ladu MJ, Reardon C, Van Eldik L, Fagan AM, Bu G, Holtzman D, Getz GS. Lipoproteins in the central nervous system. Annals of the New York Academy of Sciences. 903: 167-75. PMID 10818504 DOI: 10.1111/J.1749-6632.2000.Tb06365.X |
0.354 |
|
| 2000 |
Marzolo MP, Von Bernhardi R, Bu G, Inestrosa NC. Expression of α2-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP) in rat microglial cells Journal of Neuroscience Research. 60: 401-411. PMID 10797543 DOI: 10.1002/(Sici)1097-4547(20000501)60:3<401::Aid-Jnr15>3.0.Co;2-L |
0.404 |
|
| 2000 |
Li Y, Marzolo MP, van Kerkhof P, Strous GJ, Bu G. The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low density lipoprotein receptor-related protein. The Journal of Biological Chemistry. 275: 17187-94. PMID 10747918 DOI: 10.1074/Jbc.M000490200 |
0.361 |
|
| 2000 |
Zhuo M, Holtzman DM, Li Y, Osaka H, DeMaro J, Jacquin M, Bu G. Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 542-9. PMID 10632583 DOI: 10.1523/Jneurosci.20-02-00542.2000 |
0.381 |
|
| 2000 |
LaDu MJ, Shah JA, Reardon CA, Getz GS, Bu G, Hu J, Van Eldik LJ. Apolipoprotein E and its receptors mediate the effects of β-amyloid-induced inflammation in primary astrocyte cultures Neurobiology of Aging. 21: 148-149. DOI: 10.1016/S0197-4580(00)82468-9 |
0.353 |
|
| 1999 |
Hamik A, Setiadi H, Bu G, McEver RP, Morrissey JH. Down-regulation of monocyte tissue factor mediated by tissue factor pathway inhibitor and the low density lipoprotein receptor-related protein. The Journal of Biological Chemistry. 274: 4962-9. PMID 9988740 DOI: 10.1074/Jbc.274.8.4962 |
0.373 |
|
| 1998 |
Obermoeller LM, Ghen Z, Schwartz AL, Bu G. Ca2+ and receptor-associated protein are independently required for proper folding and disulfide bond formation of the low density lipoprotein receptor-related protein Journal of Biological Chemistry. 273: 22374-22381. PMID 9712858 DOI: 10.1074/Jbc.273.35.22374 |
0.309 |
|
| 1998 |
Fagan AM, Murphy BA, Patel SN, Kilbridge JF, Mobley WC, Bu G, Holtzman DM. Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury. Experimental Neurology. 151: 314-25. PMID 9628766 DOI: 10.1006/Exnr.1998.6818 |
0.387 |
|
| 1998 |
Bu G, Sun Y, Schwartz AL, Holtzman DM. Nerve growth factor induces rapid increases in functional cell surface low density lipoprotein receptor-related protein Journal of Biological Chemistry. 273: 13359-13365. PMID 9582384 DOI: 10.1074/Jbc.273.21.13359 |
0.359 |
|
| 1998 |
Sun Y, Wu S, Bu G, Onifade MK, Patel SN, LaDu MJ, Fagan AM, Holtzman DM. Glial Fibrillary Acidic Protein–Apolipoprotein E (apoE) Transgenic Mice: Astrocyte-Specific Expression and Differing Biological Effects of Astrocyte-Secreted apoE3 and apoE4 Lipoproteins The Journal of Neuroscience. 18: 3261-3272. DOI: 10.1523/Jneurosci.18-09-03261.1998 |
0.435 |
|
| 1997 |
Narita M, Holtzman DM, Schwartz AL, Bu G. α2-macroglobulin complexes with and mediates the endocytosis of β- amyloid peptide via cell surface low-density lipoprotein receptor-related protein Journal of Neurochemistry. 69: 1904-1911. PMID 9349534 DOI: 10.1046/J.1471-4159.1997.69051904.X |
0.475 |
|
| 1997 |
Farhangrazi ZS, Ying H, Bu G, Dugan LL, Fagan AM, Choi DW, Holtzman DM. High density lipoprotein decreases beta-amyloid toxicity in cortical cell culture. Neuroreport. 8: 1127-30. PMID 9175098 DOI: 10.1097/00001756-199703240-00013 |
0.414 |
|
| 1997 |
Fagan AM, Bu G, Sun Y, Daugherty A, Holtzman DM. Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein. The Journal of Biological Chemistry. 271: 30121-5. PMID 8939961 DOI: 10.1074/Jbc.271.47.30121 |
0.433 |
|
| 1996 |
Bu G, Rennke S. Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein Journal of Biological Chemistry. 271: 22218-22224. PMID 8703036 DOI: 10.1074/Jbc.271.36.22218 |
0.379 |
|
| 1995 |
Warshawsky I, Bu G, Mast A, Saffitz JE, Broze GJ, Schwartz AL. The carboxy terminus of tissue factor pathway inhibitor is required for interacting with hepatoma cells in vitro and in vivo Journal of Clinical Investigation. 95: 1773-1781. PMID 7706485 DOI: 10.1172/Jci117855 |
0.33 |
|
| 1995 |
Holtzman DM, Pitas RE, Kilbridge J, Nathan B, Mahley RW, Bu G, Schwartz AL. Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line. Proceedings of the National Academy of Sciences of the United States of America. 92: 9480-4. PMID 7568158 DOI: 10.1073/Pnas.92.21.9480 |
0.439 |
|
| 1995 |
Narita M, Bu G, Olins GM, Higuchi DA, Herz J, Broze GJ, Schwartz AL. Two receptor systems are involved in the plasma clearance of tissue factor pathway inhibitor in vivo. The Journal of Biological Chemistry. 270: 24800-4. PMID 7559599 DOI: 10.1074/Jbc.270.42.24800 |
0.351 |
|
| 1995 |
Vettenranta K, Bu G, Schwartz AL. Binding and endocytosis of 39 kDa protein by MDBK cells Journal of Cellular Physiology. 164: 441-447. PMID 7542665 DOI: 10.1002/Jcp.1041640225 |
0.334 |
|
| 1994 |
Warshawsky I, Bu G, Schwartz AL. LRP and the receptor-mediated endocytosis of plasminogen activators Annals of the New York Academy of Sciences. 737: 70-87. PMID 7944155 DOI: 10.1111/J.1749-6632.1994.Tb44302.X |
0.3 |
|
| 1993 |
Iadonato SP, Bu G, Maksymovitch EA, Schwartz AL. Interaction of a 39 kDa protein with the low-density-lipoprotein-receptor-related protein (LRP) on rat hepatoma cells Biochemical Journal. 296: 867-875. PMID 8280086 DOI: 10.1042/Bj2960867 |
0.352 |
|
| 1993 |
Warshawsky I, Bu G, Schwartz AL. Identification of domains on the 39-kDa protein that inhibit the binding of ligands to the low density lipoprotein receptor-related protein Journal of Biological Chemistry. 268: 22046-22054. PMID 7691821 DOI: 10.1111/J.1749-6632.1994.Tb44357.X |
0.305 |
|
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