Bret D. Freudenthal, Ph.D. - Publications

Affiliations: 
University of Kansas Medical Center, Kansas City, KS, United States 
Area:
Cell Biology, Biochemistry
Website:
https://www.freudenthallab.com/

34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Hoitsma NM, Whitaker AM, Beckwitt EC, Jang S, Agarwal PK, Van Houten B, Freudenthal BD. AP-endonuclease 1 sculpts DNA through an anchoring tyrosine residue on the DNA intercalating loop. Nucleic Acids Research. PMID 32542366 DOI: 10.1093/nar/gkaa496  1
2020 Schaich MA, Sanford SL, Welfer GA, Johnson SA, Khoang TH, Opresko PL, Freudenthal BD. Mechanisms of nucleotide selection by telomerase. Elife. 9. PMID 32501800 DOI: 10.7554/eLife.55438  0.52
2020 Whitaker AM, Stark WJ, Flynn TS, Freudenthal BD. Molecular and structural characterization of disease-associated APE1 polymorphisms. Dna Repair. 91: 102867. PMID 32454397 DOI: 10.1016/j.dnarep.2020.102867  1
2019 Smith MR, Alnajjar KS, Hoitsma NM, Sweasy JB, Freudenthal BD. Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase β. The Journal of Biological Chemistry. PMID 31892517 DOI: 10.1074/jbc.RA119.011569  0.52
2019 McNeill DR, Whitaker AM, Stark WJ, Illuzzi JL, McKinnon PJ, Freudenthal BD, Wilson DM. Functions of the major abasic endonuclease (APE1) in cell viability and genotoxin resistance. Mutagenesis. PMID 31816044 DOI: 10.1093/mutage/gez046  1
2019 Hoitsma NM, Whitaker AM, Schaich MA, Smith MR, Fairlamb MS, Freudenthal BD. Structure and function relationships in mammalian DNA polymerases. Cellular and Molecular Life Sciences : Cmls. PMID 31722068 DOI: 10.1007/s00018-019-03368-y  1
2019 Akakpo JY, Ramachandran A, Duan L, Schaich MA, Jaeschke MW, Freudenthal BD, Ding WX, Rumack BH, Jaeschke H. Delayed Treatment with 4-Methylpyrazole Protects against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun N-Terminal Kinase. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30903181 DOI: 10.1093/toxsci/kfz077  0.52
2019 Smith MR, Shock DD, Beard WA, Greenberg MM, Freudenthal BD, Wilson SH. A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition. Nucleic Acids Research. PMID 30649431 DOI: 10.1093/nar/gkz002  0.52
2018 Whitaker AM, Freudenthal BD. APE1: A skilled nucleic acid surgeon. Dna Repair. PMID 30170830 DOI: 10.1016/j.dnarep.2018.08.012  1
2018 Fairlamb MS, Whitaker AM, Freudenthal BD. Apurinic/apyrimidinic (AP) endonuclease 1 processing of AP sites with 5' mismatches. Acta Crystallographica. Section D, Structural Biology. 74: 760-768. PMID 30082511 DOI: 10.1107/S2059798318003340  1
2018 Whitaker AM, Flynn TS, Freudenthal BD. Molecular snapshots of APE1 proofreading mismatches and removing DNA damage. Nature Communications. 9: 399. PMID 29374164 DOI: 10.1038/s41467-017-02175-y  1
2017 Bastola P, Wang F, Schaich MA, Gan T, Freudenthal BD, Chou TF, Chien J. Specific mutations in the D1-D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors. Cell Death Discovery. 3: 17065. PMID 29367883 DOI: 10.1038/cddiscovery.2017.65  0.52
2017 Schaich MA, Smith MR, Cloud AS, Holloran SM, Freudenthal BD. Structures of a DNA Polymerase Inserting Therapeutic Nucleotide Analogues. Chemical Research in Toxicology. PMID 28862449 DOI: 10.1021/acs.chemrestox.7b00173  0.52
2017 Whitaker AM, Smith MR, Schaich MA, Freudenthal BD. Capturing a mammalian DNA polymerase extending from an oxidized nucleotide. Nucleic Acids Research. PMID 28449123 DOI: 10.1093/nar/gkx293  1
2017 Whitaker AM, Schaich MA, Smith MS, Flynn TS, Freudenthal BD. Base excision repair of oxidative DNA damage: from mechanism to disease. Frontiers in Bioscience (Landmark Edition). 22: 1493-1522. PMID 28199214  1
2015 Freudenthal BD, Beard WA, Cuneo MJ, Dyrkheeva NS, Wilson SH. Capturing snapshots of APE1 processing DNA damage. Nature Structural & Molecular Biology. PMID 26458045 DOI: 10.1038/nsmb.3105  1
2015 Perera L, Freudenthal BD, Beard WA, Shock DD, Pedersen LG, Wilson SH. Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse. Proceedings of the National Academy of Sciences of the United States of America. 112: E5228-36. PMID 26351676 DOI: 10.1073/pnas.1511207112  1
2015 Fedeles BI, Freudenthal BD, Yau E, Singh V, Chang SC, Li D, Delaney JC, Wilson SH, Essigmann JM. Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer. Proceedings of the National Academy of Sciences of the United States of America. 112: E4571-80. PMID 26243878 DOI: 10.1073/pnas.1507709112  1
2015 Freudenthal BD, Beard WA, Wilson SH. New structural snapshots provide molecular insights into the mechanism of high fidelity DNA synthesis. Dna Repair. PMID 26002198 DOI: 10.1016/j.dnarep.2015.04.007  1
2015 Tsutakawa SE, Yan C, Xu X, Weinacht CP, Freudenthal BD, Yang K, Zhuang Z, Washington MT, Tainer JA, Ivanov I. Structurally distinct ubiquitin- and sumo-modified PCNA: implications for their distinct roles in the DNA damage response. Structure (London, England : 1993). 23: 724-33. PMID 25773143 DOI: 10.1016/j.str.2015.02.008  1
2015 Freudenthal BD, Beard WA, Perera L, Shock DD, Kim T, Schlick T, Wilson SH. Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide. Nature. 517: 635-9. PMID 25409153 DOI: 10.1038/nature13886  1
2014 Prasad R, Horton JK, Chastain PD, Gassman NR, Freudenthal BD, Hou EW, Wilson SH. Suicidal cross-linking of PARP-1 to AP site intermediates in cells undergoing base excision repair. Nucleic Acids Research. 42: 6337-51. PMID 24771347 DOI: 10.1093/nar/gku288  1
2014 Li Y, Freudenthal BD, Beard WA, Wilson SH, Schlick T. Optimal and variant metal-ion routes in DNA polymerase β's conformational pathways. Journal of the American Chemical Society. 136: 3630-9. PMID 24511902 DOI: 10.1021/ja412701f  1
2014 Freudenthal BD, Beard WA, Wilson SH. Watching a DNA polymerase in action. Cell Cycle (Georgetown, Tex.). 13: 691-2. PMID 24424116 DOI: 10.4161/cc.27789  1
2013 Freudenthal BD, Beard WA, Shock DD, Wilson SH. Observing a DNA polymerase choose right from wrong. Cell. 154: 157-68. PMID 23827680 DOI: 10.1016/j.cell.2013.05.048  1
2013 Freudenthal BD, Beard WA, Wilson SH. DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion. Nucleic Acids Research. 41: 1848-58. PMID 23267011 DOI: 10.1093/nar/gks1276  1
2012 Freudenthal BD, Beard WA, Wilson SH. Structures of dNTP intermediate states during DNA polymerase active site assembly. Structure (London, England : 1993). 20: 1829-37. PMID 22959623 DOI: 10.1016/j.str.2012.08.008  1
2012 Dieckman LM, Freudenthal BD, Washington MT. PCNA structure and function: insights from structures of PCNA complexes and post-translationally modified PCNA. Sub-Cellular Biochemistry. 62: 281-99. PMID 22918591 DOI: 10.1007/978-94-007-4572-8_15  1
2011 Tsutakawa SE, Van Wynsberghe AW, Freudenthal BD, Weinacht CP, Gakhar L, Washington MT, Zhuang Z, Tainer JA, Ivanov I. Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA. Proceedings of the National Academy of Sciences of the United States of America. 108: 17672-7. PMID 22006297 DOI: 10.1073/pnas.1110480108  1
2011 Freudenthal BD, Brogie JE, Gakhar L, Kondratick CM, Washington MT. Crystal structure of SUMO-modified proliferating cell nuclear antigen. Journal of Molecular Biology. 406: 9-17. PMID 21167178 DOI: 10.1016/j.jmb.2010.12.015  1
2010 Freudenthal BD, Gakhar L, Ramaswamy S, Washington MT. Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange. Nature Structural & Molecular Biology. 17: 479-84. PMID 20305653 DOI: 10.1038/nsmb.1776  1
2010 Washington MT, Carlson KD, Freudenthal BD, Pryor JM. Variations on a theme: eukaryotic Y-family DNA polymerases. Biochimica Et Biophysica Acta. 1804: 1113-23. PMID 19616647 DOI: 10.1016/j.bbapap.2009.07.004  1
2009 Freudenthal BD, Gakhar L, Ramaswamy S, Washington MT. A charged residue at the subunit interface of PCNA promotes trimer formation by destabilizing alternate subunit interactions. Acta Crystallographica. Section D, Biological Crystallography. 65: 560-6. PMID 19465770 DOI: 10.1107/S0907444909011329  1
2008 Freudenthal BD, Ramaswamy S, Hingorani MM, Washington MT. Structure of a mutant form of proliferating cell nuclear antigen that blocks translesion DNA synthesis. Biochemistry. 47: 13354-61. PMID 19053247 DOI: 10.1021/bi8017762  1
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