Year |
Citation |
Score |
2022 |
Bocci G, Oprea TI, Benet LZ. State of the Art and Uses for the Biopharmaceutics Drug Disposition Classification System (BDDCS): New Additions, Revisions, and Citation References. The Aaps Journal. 24: 37. PMID 35199251 DOI: 10.1208/s12248-022-00687-0 |
0.339 |
|
2020 |
Benet LZ, Sodhi JK. Investigating the Theoretical Basis for In Vitro-In Vivo Extrapolation (IVIVE) in Predicting Drug Metabolic Clearance and Proposing Future Experimental Pathways. The Aaps Journal. 22: 120. PMID 32914238 DOI: 10.1208/S12248-020-00501-9 |
0.399 |
|
2020 |
Sodhi JK, Benet LZ. The Necessity of Using Changes in Absorption Time to Implicate Intestinal Transporter Involvement in Oral Drug-Drug Interactions. The Aaps Journal. 22: 111. PMID 32808084 DOI: 10.1208/S12248-020-00469-6 |
0.435 |
|
2020 |
Di L, Artursson P, Avdeef A, Benet L, Houston B, Kansy M, Kerns E, Lennernäs H, Smith D, Sugano K. The Critical Role of Passive Permeability in Designing Successful Drugs. Chemmedchem. PMID 32743945 DOI: 10.1002/Cmdc.202000419 |
0.402 |
|
2020 |
Sodhi JK, Huang CH, Benet LZ. Volume of Distribution is Unaffected by Metabolic Drug-Drug Interactions. Clinical Pharmacokinetics. PMID 32725383 DOI: 10.1007/S40262-020-00926-7 |
0.414 |
|
2020 |
Sodhi JK, Wang HJ, Benet LZ. Are there any experimental perfusion data that preferentially support the dispersion and parallel tube models over the well-stirred model of organ elimination? Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 32305951 DOI: 10.1124/Dmd.120.090530 |
0.383 |
|
2020 |
Sodhi JK, Liu S, Benet LZ. Challenging the Relevance of Unbound Tissue-to-Blood Partition Coefficient (Kp) on Prediction of Drug-Drug Interactions. Pharmaceutical Research. 37: 73. PMID 32215750 DOI: 10.1007/S11095-020-02797-W |
0.394 |
|
2020 |
Sodhi JK, Benet LZ. A Simple Methodology to Differentiate Changes in Bioavailability from Changes in Clearance Following Oral Dosing of Metabolized Drugs. Clinical Pharmacology and Therapeutics. PMID 32150643 DOI: 10.1002/Cpt.1828 |
0.414 |
|
2020 |
Liu W, Yan T, Chen K, Yang L, Benet L, Zhai S. Predicting Interactions between Rifampin and Antihypertensive Drugs Using the Biopharmaceutics Drug Disposition Classification System (BDDCS). Pharmacotherapy. PMID 32100890 DOI: 10.1002/Phar.2380 |
0.395 |
|
2020 |
Sun A, Benet LZ. Late-Stage Failures of Monoclonal Antibody Drugs: A Retrospective Case Study Analysis. Pharmacology. 1-19. PMID 31910414 DOI: 10.1159/000505379 |
0.325 |
|
2019 |
Bocci G, Benet LZ, Oprea TI. Can BDDCS illuminate targets in drug design? Drug Discovery Today. PMID 31585170 DOI: 10.1016/J.Drudis.2019.09.021 |
0.384 |
|
2019 |
Wang HJ, Benet LZ. Protein binding and hepatic clearance: Re-examining the discrimination between models of hepatic clearance with diazepam in the isolated perfused rat liver preparation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31563869 DOI: 10.1124/Dmd.119.088872 |
0.329 |
|
2019 |
Bowman CM, Benet LZ. In Vitro - In Vivo Accuracy: The CYP3A4 Anomaly. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31551322 DOI: 10.1124/Dmd.119.088427 |
0.339 |
|
2019 |
Benet LZ, Bowman CM, Sodhi JK. How Transporters Have Changed Basic Pharmacokinetic Understanding. The Aaps Journal. 21: 103. PMID 31482335 DOI: 10.1208/S12248-019-0373-3 |
0.411 |
|
2019 |
Moriya Y, Kogame A, Tagawa Y, Morohashi A, Kondo T, Asahi S, Benet LZ. The enhancement of subcutaneous first-pass metabolism causes non-linear pharmacokinetics of TAK-448 after a single subcutaneous administration to rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 31201213 DOI: 10.1124/Dmd.119.087148 |
0.358 |
|
2019 |
Benet LZ, Bowman CM, Koleske ML, Rinaldi CL, Sodhi JK. Understanding drug-drug interaction and pharmacogenomic changes in pharmacokinetics for metabolized drugs. Journal of Pharmacokinetics and Pharmacodynamics. PMID 30911879 DOI: 10.1007/S10928-019-09626-7 |
0.459 |
|
2019 |
Bowman CM, Benet LZ. In vitro-in vivo extrapolation and hepatic clearance dependent underprediction. Journal of Pharmaceutical Sciences. PMID 30817922 DOI: 10.1016/J.Xphs.2019.02.009 |
0.32 |
|
2019 |
Kogame A, Moriya Y, Mori I, Pan L, Morohashi A, Ebihara T, Fukui H, Tagawa Y, Benet LZ. Characterization of fasiglifam-related liver toxicity in dogs. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 30765394 DOI: 10.1124/Dmd.118.084889 |
0.32 |
|
2019 |
Bowman CM, Okochi H, Benet LZ. The Presence of a Transporter-Induced Protein Binding Shift: A new Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 30674616 DOI: 10.1124/Dmd.118.085779 |
0.359 |
|
2019 |
Jayachandran P, Okochi H, Frassetto LA, Park W, Fang L, Zhao L, Benet LZ. Evaluating Within-Subject Variability for Narrow Therapeutic Index Drugs. Clinical Pharmacology and Therapeutics. PMID 30652304 DOI: 10.1002/Cpt.1293 |
0.391 |
|
2018 |
Wolfe AR, Neitz RJ, Burlingame M, Suzuki BM, Lim KC, Scheideler M, Nelson DL, Benet LZ, Caffrey CR. TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling. International Journal For Parasitology. Drugs and Drug Resistance. 8: 571-586. PMID 30503203 DOI: 10.1016/J.Ijpddr.2018.10.004 |
0.333 |
|
2018 |
Bowman CM, Benet LZ. An examination of protein binding and protein-facilitated uptake relating to in vitro-in vivo extrapolation. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 123: 502-514. PMID 30098391 DOI: 10.1016/J.Ejps.2018.08.008 |
0.332 |
|
2018 |
Chan R, Benet LZ. Evaluation of the Relevance of DILI Predictive Hypotheses in Early Drug Development: Review of Methodologies BDDCS Classification. Toxicology Research. 7: 358-370. PMID 29785262 DOI: 10.1039/C8Tx00016F |
0.436 |
|
2018 |
Benet LZ. Predicting Pharmacokinetics/Pharmacodynamics in the Individual Patient: Separating Reality From Hype. Journal of Clinical Pharmacology. PMID 29663413 DOI: 10.1002/Jcph.1105 |
0.443 |
|
2018 |
Liu W, Guan X, Yu Z, Chen K, Benet L, Zhai S. A Drug-drug Interaction Between Cyclosporine and Nystatin. Clinical Therapeutics. PMID 29551534 DOI: 10.1016/J.Clinthera.2018.02.008 |
0.406 |
|
2018 |
Parasrampuria DA, Benet LZ, Sharma A. Why Drugs Fail in Late Stages of Development: Case Study Analyses from the Last Decade and Recommendations. The Aaps Journal. 20: 46. PMID 29536211 DOI: 10.1208/S12248-018-0204-Y |
0.346 |
|
2018 |
Phung N, Kuncze K, Okochi H, Louie A, Benet LZ, Ofokotun I, Haas DW, Currier JS, Chawana TD, Sheth AN, Bacchetti P, Gandhi M, Horng H. Development and Validation of an Assay to Analyze Atazanavir in Human Hair Via Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). Rapid Communications in Mass Spectrometry : Rcm. PMID 29315954 DOI: 10.1002/Rcm.8058 |
0.714 |
|
2018 |
Benet LZ. The application of BCS and BDDCS in drug discovery and development Drug Metabolism and Pharmacokinetics. 33: S2. DOI: 10.1016/J.Dmpk.2017.11.014 |
0.374 |
|
2017 |
Chan R, Benet LZ. Measures of BSEP Inhibition In Vitro Are Not Useful Predictors of DILI. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 29272540 DOI: 10.1093/Toxsci/Kfx284 |
0.425 |
|
2017 |
Koss CA, Hosek SG, Bacchetti P, Anderson PL, Liu AY, Horng H, Benet LZ, Kuncze K, Louie A, Saberi P, Wilson CM, Gandhi M. Comparison of Measures of Adherence to HIV Preexposure Prophylaxis among Adolescent and Young Men Who Have Sex with Men in the United States. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. PMID 29020194 DOI: 10.1093/Cid/Cix755 |
0.67 |
|
2017 |
Benet LZ, Liu S, Wolfe AR. The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio. Clinical Pharmacology and Therapeutics. 103: 521-525. PMID 28762489 DOI: 10.1002/Cpt.802 |
0.355 |
|
2017 |
Noguchi S, Nishimura T, Mukaida S, Benet LZ, Nakashima E, Tomi M. Cellular Uptake of Levocetirizine by Organic Anion Transporter 4. Journal of Pharmaceutical Sciences. PMID 28385546 DOI: 10.1016/J.Xphs.2017.03.026 |
0.313 |
|
2017 |
Wu HF, Hristeva N, Chang J, Liang X, Li R, Frassetto L, Benet LZ. Rosuvastatin Pharmacokinetics in Asian and White Subjects wild-type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions. Journal of Pharmaceutical Sciences. PMID 28385543 DOI: 10.1016/J.Xphs.2017.03.027 |
0.309 |
|
2017 |
Chan R, Benet LZ. Evaluation of DILI Predictive Hypotheses in Early Drug Development. Chemical Research in Toxicology. PMID 28257576 DOI: 10.1021/Acs.Chemrestox.7B00025 |
0.424 |
|
2017 |
Koss CA, Bacchetti P, Hillier SL, Livant E, Horng H, Mgodi N, Mirembe BG, Gomez Feliciano K, Horn S, Liu AY, Glidden DV, Grant RM, Benet LZ, Louie A, van der Straten A, et al. Differences in Cumulative Exposure and Adherence to Tenofovir in the VOICE, iPrEx OLE, and PrEP Demo Studies as Determined via Hair Concentrations. Aids Research and Human Retroviruses. PMID 28253024 DOI: 10.1089/aid.2016.0202 |
0.697 |
|
2016 |
Li J, Larregieu CA, Benet LZ. Classification of natural products as sources of drugs according to the biopharmaceutics drug disposition classification system (BDDCS). Chinese Journal of Natural Medicines. 14: 888-897. PMID 28262115 DOI: 10.1016/S1875-5364(17)30013-4 |
0.793 |
|
2016 |
Faber KP, Wu HF, Yago MR, Xu X, Kadiyala P, Frassetto LA, Benet LZ. Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption. Pharmaceutical Research. PMID 28028768 DOI: 10.1007/S11095-016-2090-2 |
0.343 |
|
2016 |
Gandhi M, Glidden DV, Mayer K, Schechter M, Buchbinder S, Grinsztejn B, Hosek S, Casapia M, Guanira J, Bekker LG, Louie A, Horng H, Benet LZ, Liu A, Grant RM. Association of age, baseline kidney function, and medication exposure with declines in creatinine clearance on pre-exposure prophylaxis: an observational cohort study. The Lancet. Hiv. PMID 27658870 DOI: 10.1016/S2352-3018(16)30153-9 |
0.689 |
|
2016 |
Bowman CM, Benet LZ. Hepatic clearance predictions from in vitro-in vivo extrapolation and BDDCS. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 27519549 DOI: 10.1124/Dmd.116.071514 |
0.389 |
|
2016 |
Benet LZ, Hosey CM, Ursu O, Oprea TI. BDDCS, the Rule of 5 and drugability. Advanced Drug Delivery Reviews. PMID 27182629 DOI: 10.1016/J.Addr.2016.05.007 |
0.341 |
|
2016 |
Mave V, Chandanwale A, Kinikar A, Khadse S, Kagal A, Gupte N, Suryavanshi N, Nimkar S, Koli H, Khwaja S, Bharadwaj R, Joshi S, Horng H, Benet LZ, Ramachandran G, et al. Isoniazid hair concentrations in children with tuberculosis: a proof of concept study. The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease. 20: 844-847. PMID 27155191 DOI: 10.5588/Ijtld.15.0882 |
0.719 |
|
2016 |
Chan R, Wei CY, Chen YT, Benet LZ. Use of the Biopharmaceutics Drug Disposition Classification System (BDDCS) to Help Predict the Occurrence of Idiosyncratic Cutaneous Adverse Drug Reactions Associated with Antiepileptic Drug Usage. The Aaps Journal. PMID 26951484 DOI: 10.1208/S12248-016-9898-X |
0.313 |
|
2016 |
Estudante M, Soveral G, Morais JG, Benet LZ. Insights into solute carriers: physiological functions and implications in disease and pharmacokinetics Medchemcomm. 7: 1462-1478. DOI: 10.1039/C6Md00188B |
0.412 |
|
2015 |
Hosey CM, Chan R, Benet LZ. BDDCS Predictions, Self-Correcting Aspects of BDDCS Assignments, BDDCS Assignment Corrections, and Classification for more than 175 Additional Drugs. The Aaps Journal. PMID 26589308 DOI: 10.1208/S12248-015-9845-2 |
0.421 |
|
2015 |
Zheng Y, Chen X, Benet LZ. Reliability of In Vitro and In Vivo Methods for Predicting the Effect of P-Glycoprotein on the Delivery of Antidepressants to the Brain. Clinical Pharmacokinetics. PMID 26293617 DOI: 10.1007/S40262-015-0310-2 |
0.352 |
|
2015 |
Garrison KL, Sahin S, Benet LZ. Few Drugs Display Flip-Flop Pharmacokinetics and These Are Primarily Associated with Classes 3 and 4 of the BDDCS. Journal of Pharmaceutical Sciences. 104: 3229-35. PMID 26010239 DOI: 10.1002/Jps.24505 |
0.443 |
|
2015 |
Hosey CM, Benet LZ. Predicting the extent of metabolism using in vitro permeability rate measurements and in silico permeability rate predictions. Molecular Pharmaceutics. 12: 1456-66. PMID 25816851 DOI: 10.1021/Mp500783G |
0.39 |
|
2015 |
Zheng Y, Benet LZ, Okochi H, Chen X. pH Dependent but not P-gp Dependent Bidirectional Transport Study of S-propranolol: The Importance of Passive Diffusion. Pharmaceutical Research. 32: 2516-26. PMID 25690341 DOI: 10.1007/S11095-015-1640-3 |
0.35 |
|
2015 |
Parasrampuria DA, Benet LZ. Inclusion of placebos and blinding for ascending dose first-in-human studies and other underpowered phase 1 studies has not been justified and on balance is not useful. Basic & Clinical Pharmacology & Toxicology. 117: 44-51. PMID 25406995 DOI: 10.1111/Bcpt.12352 |
0.337 |
|
2015 |
Estudante M, Sampayo C, Carvalho C, Morais J, Benet L. Correlation of rat intestinal permeability rate measures with human absorption and metabolism to improve BCS and BDDCS predictions Toxicology Letters. 238: S379. DOI: 10.1016/J.Toxlet.2015.08.1082 |
0.312 |
|
2014 |
Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. The Aaps Journal. 16: 1358-65. PMID 25274610 DOI: 10.1208/S12248-014-9673-9 |
0.424 |
|
2014 |
Hosey CM, Broccatelli F, Benet LZ. Predicting when biliary excretion of parent drug is a major route of elimination in humans. The Aaps Journal. 16: 1085-96. PMID 25004821 DOI: 10.1208/S12248-014-9636-1 |
0.453 |
|
2014 |
Larregieu CA, Benet LZ. Distinguishing between the permeability relationships with absorption and metabolism to improve BCS and BDDCS predictions in early drug discovery. Molecular Pharmaceutics. 11: 1335-44. PMID 24628254 DOI: 10.1021/Mp4007858 |
0.811 |
|
2013 |
Estudante M, Maya M, Morais JG, Soveral G, Benet LZ. Effect of P-glycoprotein on the rat intestinal permeability and metabolism of the BDDCS class 1 drug verapamil. Molecular Pharmaceutics. 10: 4038-45. PMID 24044638 DOI: 10.1021/Mp400381P |
0.45 |
|
2013 |
Smelick GS, Heffron TP, Chu L, Dean B, West DA, Duvall SL, Lum BL, Budha N, Holden SN, Benet LZ, Frymoyer A, Dresser MJ, Ware JA. Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development. Molecular Pharmaceutics. 10: 4055-62. PMID 24044612 DOI: 10.1021/Mp400403S |
0.307 |
|
2013 |
Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L. Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients. Biopharmaceutics & Drug Disposition. 34: 442-51. PMID 24030928 DOI: 10.1002/Bdd.1860 |
0.404 |
|
2013 |
Horng H, Benet LZ. The nonenzymatic reactivity of the acyl-linked metabolites of mefenamic acid toward amino and thiol functional group bionucleophiles. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1923-33. PMID 23975029 DOI: 10.1124/Dmd.113.053223 |
0.712 |
|
2013 |
Silber BM, Rao S, Fife KL, Gallardo-Godoy A, Renslo AR, Dalvie DK, Giles K, Freyman Y, Elepano M, Gever JR, Li Z, Jacobson MP, Huang Y, Benet LZ, Prusiner SB. Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. Pharmaceutical Research. 30: 932-50. PMID 23417511 DOI: 10.1007/S11095-012-0912-4 |
0.351 |
|
2013 |
Horng H, Benet LZ. Characterization of the acyl-adenylate linked metabolite of mefenamic Acid. Chemical Research in Toxicology. 26: 465-76. PMID 23402341 DOI: 10.1021/Tx300520J |
0.735 |
|
2013 |
Larregieu CA, Benet LZ. Drug discovery and regulatory considerations for improving in silico and in vitro predictions that use Caco-2 as a surrogate for human intestinal permeability measurements. The Aaps Journal. 15: 483-97. PMID 23344793 DOI: 10.1208/S12248-013-9456-8 |
0.795 |
|
2013 |
Budha NR, Benet LZ, Ware JA. Response to "drug interactions produced by proton pump inhibitors: Not simply a ph effect" Clinical Pharmacology and Therapeutics. 93: 151. PMID 23169432 DOI: 10.1038/Clpt.2012.206 |
0.325 |
|
2013 |
Benet LZ. The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development. Journal of Pharmaceutical Sciences. 102: 34-42. PMID 23147500 DOI: 10.1002/Jps.23359 |
0.38 |
|
2013 |
Estudante M, Morais JG, Soveral G, Benet LZ. Intestinal drug transporters: an overview. Advanced Drug Delivery Reviews. 65: 1340-56. PMID 23041352 DOI: 10.1016/J.Addr.2012.09.042 |
0.431 |
|
2012 |
Benet LZ. A step closer to personalized chemotherapy: Consideration of the influence of genetic variation in hepatic uptake transporters on the metabolism of CYP3A substrates Clinical Pharmacology and Therapeutics. 92: 551-552. PMID 23085879 DOI: 10.1038/Clpt.2012.165 |
0.416 |
|
2012 |
Budha NR, Frymoyer A, Smelick GS, Jin JY, Yago MR, Dresser MJ, Holden SN, Benet LZ, Ware JA. Drug absorption interactions between oral targeted anticancer agents and PPIs: Is pH-dependent solubility the achilles heel of targeted therapy Clinical Pharmacology and Therapeutics. 92: 203-213. PMID 22739140 DOI: 10.1038/Clpt.2012.73 |
0.308 |
|
2012 |
Liu W, Okochi H, Benet LZ, Zhai SD. Sotalol permeability in cultured-cell, rat intestine, and PAMPA system. Pharmaceutical Research. 29: 1768-74. PMID 22350803 DOI: 10.1007/S11095-012-0699-3 |
0.348 |
|
2012 |
Benet LZ. Benet L Z and Galeazzi R L: noncompartmental determination of the steady-state volume of distribution, J Pharm Sci 68, 1071-1074, 1979--the backstory. The Aaps Journal. 14: 164-7. PMID 22302585 DOI: 10.1208/S12248-012-9326-9 |
0.318 |
|
2012 |
Broccatelli F, Larregieu CA, Cruciani G, Oprea TI, Benet LZ. Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Advanced Drug Delivery Reviews. 64: 95-109. PMID 22261306 DOI: 10.1016/J.Addr.2011.12.008 |
0.804 |
|
2012 |
Broccatelli F, Cruciani G, Benet LZ, Oprea TI. BDDCS class prediction for new molecular entities. Molecular Pharmaceutics. 9: 570-80. PMID 22224483 DOI: 10.1021/Mp2004302 |
0.412 |
|
2011 |
Grover A, Frassetto LA, Benet LZ, Chakkera HA. Pharmacokinetic differences corroborate observed low tacrolimus dosage in Native American renal transplant patients. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 2017-9. PMID 21849516 DOI: 10.1124/Dmd.111.041350 |
0.576 |
|
2011 |
Benet LZ, Broccatelli F, Oprea TI. BDDCS applied to over 900 drugs. The Aaps Journal. 13: 519-47. PMID 21818695 DOI: 10.1208/S12248-011-9290-9 |
0.433 |
|
2011 |
Reyes M, Benet LZ. Effects of uremic toxins on transport and metabolism of different biopharmaceutics drug disposition classification system xenobiotics. Journal of Pharmaceutical Sciences. 100: 3831-42. PMID 21618544 DOI: 10.1002/Jps.22640 |
0.686 |
|
2011 |
Park MS, Okochi H, Benet LZ. Is Ciprofloxacin a Substrate of P-glycoprotein? Archives of Drug Information. 4: 1-9. PMID 21572514 DOI: 10.1111/J.1753-5174.2010.00032.X |
0.31 |
|
2011 |
Grover A, Benet LZ. Intermittent drug dosing intervals guided by the operational multiple dosing half lives for predictable plasma accumulation and fluctuation. Journal of Pharmacokinetics and Pharmacodynamics. 38: 369-83. PMID 21499748 DOI: 10.1007/S10928-011-9198-0 |
0.611 |
|
2011 |
Chen ML, Amidon GL, Benet LZ, Lennernas H, Yu LX. The BCS, BDDCS, and regulatory guidances. Pharmaceutical Research. 28: 1774-8. PMID 21491148 DOI: 10.1007/S11095-011-0438-1 |
0.447 |
|
2011 |
Gottschalk S, Cummins CL, Leibfritz D, Christians U, Benet LZ, Serkova NJ. Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism. Neurotoxicology. 32: 50-7. PMID 21075140 DOI: 10.1016/J.Neuro.2010.10.006 |
0.607 |
|
2011 |
Benet LZ. Transporter-Enzyme Interplay and Its Importance in Defining Drug Absorption and Disposition Annual Review of Pharmacology and Toxicology. 52: 110301101444027. DOI: 10.1146/Annurev-Pharmtox-010611-134726 |
0.397 |
|
2010 |
Benet LZ. Clearance (née Rowland) concepts: a downdate and an update. Journal of Pharmacokinetics and Pharmacodynamics. 37: 529-39. PMID 21113650 DOI: 10.1007/S10928-010-9187-8 |
0.443 |
|
2010 |
Aarons L, Benet LZ. Founding figures of pharmacokinetics: tribute to Malcolm Rowland. Journal of Pharmacokinetics and Pharmacodynamics. 37: 525-7. PMID 21069561 DOI: 10.1007/S10928-010-9178-9 |
0.36 |
|
2010 |
Frymoyer A, Shugarts S, Browne M, Wu AHB, Frassetto L, Benet LZ. Effect of single-dose rifampin on the pharmacokinetics of warfarin in healthy volunteers Clinical Pharmacology and Therapeutics. 88: 540-547. PMID 20703222 DOI: 10.1038/Clpt.2010.142 |
0.378 |
|
2010 |
Benet LZ, Larregieu CA. The FDA should eliminate the ambiguities in the current BCS biowaiver guidance and make public the drugs for which BCS biowaivers have been granted. Clinical Pharmacology and Therapeutics. 88: 405-7. PMID 20668447 DOI: 10.1038/Clpt.2010.149 |
0.8 |
|
2010 |
Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, et al. Membrane transporters in drug development. Nature Reviews. Drug Discovery. 9: 215-36. PMID 20190787 DOI: 10.1038/Nrd3028 |
0.417 |
|
2010 |
Sun H, Frassetto LA, Huang Y, Benet LZ. Hepatic clearance, but not gut availability, of erythromycin is altered in patients with end-stage renal disease Clinical Pharmacology and Therapeutics. 87: 465-472. PMID 20090676 DOI: 10.1038/Clpt.2009.247 |
0.344 |
|
2010 |
Benet LZ. Predicting drug disposition via application of a Biopharmaceutics Drug Disposition Classification System. Basic & Clinical Pharmacology & Toxicology. 106: 162-7. PMID 20002064 DOI: 10.1111/J.1742-7843.2009.00498.X |
0.46 |
|
2010 |
Grillo MP, Wait JC, Tadano Lohr M, Khera S, Benet LZ. Stereoselective flunoxaprofen-S-acyl-glutathione thioester formation mediated by acyl-CoA formation in rat hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 133-42. PMID 19786506 DOI: 10.1124/Dmd.109.029371 |
0.314 |
|
2010 |
Grover A, Benet LZ. Transporter-based drug-drug interactions and their effect on distribution volumes Enzyme- and Transporter-Based Drug-Drug Interactions: Progress and Future Challenges. 437-471. DOI: 10.1007/978-1-4419-0840-7_18 |
0.586 |
|
2009 |
Benet LZ. The drug transporter-metabolism alliance: uncovering and defining the interplay. Molecular Pharmaceutics. 6: 1631-43. PMID 19874004 DOI: 10.1021/Mp900253N |
0.421 |
|
2009 |
Benet LZ. A holy grail of clinical pharmacology: Prediction of drug pharmacokinetics and pharmacodynamics in the individual patient Clinical Pharmacology and Therapeutics. 86: 133-134. PMID 19621007 DOI: 10.1038/Clpt.2009.102 |
0.422 |
|
2009 |
Shugarts S, Benet LZ. The role of transporters in the pharmacokinetics of orally administered drugs. Pharmaceutical Research. 26: 2039-54. PMID 19568696 DOI: 10.1007/S11095-009-9924-0 |
0.821 |
|
2009 |
de Souza J, Benet LZ, Huang Y, Storpirtis S. Comparison of bidirectional lamivudine and zidovudine transport using MDCK, MDCK-MDR1, and Caco-2 cell monolayers. Journal of Pharmaceutical Sciences. 98: 4413-9. PMID 19472342 DOI: 10.1002/Jps.21744 |
0.357 |
|
2009 |
Grover A, Benet LZ. Effects of drug transporters on volume of distribution. The Aaps Journal. 11: 250-61. PMID 19399628 DOI: 10.1208/S12248-009-9102-7 |
0.623 |
|
2009 |
Zheng HX, Huang Y, Frassetto LA, Benet LZ. Elucidating rifampin's inducing and inhibiting effects on glyburide pharmacokinetics and blood glucose in healthy volunteers: Unmasking the differential effects of enzyme induction and transporter inhibition for a drug and its primary metabolite Clinical Pharmacology and Therapeutics. 85: 78-85. PMID 18843263 DOI: 10.1038/Clpt.2008.186 |
0.416 |
|
2009 |
Gwaza L, Wolfe AR, Benet LZ, Guglielmo BJ, Chagwedera TE, Maponga CC, Masimirembwa CM. In vitro inhibitory effects of Hypoxis obtusa and Dicoma anomala on cyp450 enzymes and p-glycoprotein African Journal of Pharmacy and Pharmacology. 3: 539-546. DOI: 10.5897/Ajpp.9000184 |
0.396 |
|
2008 |
Monera TG, Wolfe AR, Maponga CC, Benet LZ, Guglielmo J. Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4. Journal of Infection in Developing Countries. 2: 379-83. PMID 19745507 DOI: 10.3855/Jidc.201 |
0.307 |
|
2008 |
Sahin S, Benet LZ. The operational multiple dosing half-life: a key to defining drug accumulation in patients and to designing extended release dosage forms. Pharmaceutical Research. 25: 2869-77. PMID 19015955 DOI: 10.1007/S11095-008-9787-9 |
0.303 |
|
2008 |
Grillo MP, Hua F, March KL, Benet LZ, Knutson CG, Ware JA. Gamma-glutamyltranspeptidase-mediated degradation of diclofenac-S-acyl-glutathione in vitro and in vivo in rat. Chemical Research in Toxicology. 21: 1933-8. PMID 18693772 DOI: 10.1021/Tx800073P |
0.301 |
|
2008 |
Benet LZ, Amidon GL, Barends DM, Lennernäs H, Polli JE, Shah VP, Stavchansky SA, Yu LX. The use of BDDCS in classifying the permeability of marketed drugs. Pharmaceutical Research. 25: 483-8. PMID 18236138 DOI: 10.1007/S11095-007-9523-X |
0.424 |
|
2008 |
Custodio JM, Wu CY, Benet LZ. Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption. Advanced Drug Delivery Reviews. 60: 717-33. PMID 18199522 DOI: 10.1016/J.Addr.2007.08.043 |
0.75 |
|
2008 |
Li C, Grillo MP, Badagnani I, Fife KL, Benet LZ. Differential effects of fibrates on the metabolic activation of 2-phenylpropionic acid in rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 682-7. PMID 18187563 DOI: 10.1124/Dmd.107.017764 |
0.56 |
|
2007 |
Frassetto LA, Browne M, Cheng A, Wolfe AR, Roland ME, Stock PG, Carlson L, Benet LZ. Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 7: 2816-20. PMID 17949460 DOI: 10.1111/J.1600-6143.2007.02007.X |
0.336 |
|
2007 |
Frassetto LA, Poon S, Tsourounis C, Valera C, Benet LZ. Effects of uptake and efflux transporter inhibition on erythromycin breath test results Clinical Pharmacology and Therapeutics. 81: 828-832. PMID 17361125 DOI: 10.1038/Sj.Clpt.6100148 |
0.332 |
|
2007 |
Olsen J, Li C, Skonberg C, Bjørnsdottir I, Sidenius U, Benet LZ, Hansen SH. Studies on the metabolism of tolmetin to the chemically reactive acyl-coenzyme A thioester intermediate in rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 758-64. PMID 17303625 DOI: 10.1124/Dmd.106.013334 |
0.55 |
|
2007 |
Benet LZ. Review and critique of the institute of medicine report "The future of drug safety" Clinical Pharmacology and Therapeutics. 81: 158-161. PMID 17259941 DOI: 10.1038/Sj.Clpt.6100083 |
0.336 |
|
2007 |
Lau YY, Huang Y, Frassetto L, Benet LZ. effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers. Clinical Pharmacology and Therapeutics. 81: 194-204. PMID 17192770 DOI: 10.1038/Sj.Clpt.6100038 |
0.619 |
|
2006 |
Lam JL, Shugarts SB, Okochi H, Benet LZ. Elucidating the effect of final-day dosing of rifampin in induction studies on hepatic drug disposition and metabolism. The Journal of Pharmacology and Experimental Therapeutics. 319: 864-70. PMID 16905688 DOI: 10.1124/Jpet.106.108282 |
0.8 |
|
2006 |
Lam JL, Okochi H, Huang Y, Benet LZ. In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: characterizing the importance of transporter-enzyme interplay. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1336-44. PMID 16698890 DOI: 10.1124/Dmd.106.009258 |
0.794 |
|
2006 |
Lau YY, Okochi H, Huang Y, Benet LZ. Pharmacokinetics of atorvastatin and its hydroxy metabolites in rats and the effects of concomitant rifampicin single doses: relevance of first-pass effect from hepatic uptake transporters, and intestinal and hepatic metabolism. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1175-81. PMID 16624870 DOI: 10.1124/Dmd.105.009076 |
0.64 |
|
2006 |
Huang Y, Okochi H, May BC, Legname G, Prusiner SB, Benet LZ, Guglielmo BJ, Lin ET. Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1136-44. PMID 16581945 DOI: 10.1124/Dmd.105.008664 |
0.381 |
|
2006 |
Lau YY, Okochi H, Huang Y, Benet LZ. Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: application of in vitro and ex situ systems. The Journal of Pharmacology and Experimental Therapeutics. 316: 762-71. PMID 16258024 DOI: 10.1124/Jpet.105.093088 |
0.63 |
|
2006 |
Sun H, Frassetto L, Benet LZ. Effects of renal failure on drug transport and metabolism. Pharmacology & Therapeutics. 109: 1-11. PMID 16085315 DOI: 10.1016/J.Pharmthera.2005.05.010 |
0.396 |
|
2006 |
Lau YY, Okochi H, Huang Y, Benet LZ. Response to comments on "multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: Application of in vitro and ex situ systems" [2] Journal of Pharmacology and Experimental Therapeutics. 316: 1387. DOI: 10.1124/jpet.105.099473 |
0.495 |
|
2005 |
Olsen J, Li C, Bjørnsdottir I, Sidenius U, Hansen SH, Benet LZ. In vitro and in vivo studies on acyl-coenzyme A-dependent bioactivation of zomepirac in rats. Chemical Research in Toxicology. 18: 1729-36. PMID 16300382 DOI: 10.1021/Tx0501785 |
0.525 |
|
2005 |
Chang JH, Benet LZ. Glucuronidation and the transport of the glucuronide metabolites in LLC-PK1 cells. Molecular Pharmaceutics. 2: 428-34. PMID 16196496 DOI: 10.1021/Mp050018M |
0.384 |
|
2005 |
Frassetto L, Baluom M, Jacobsen W, Christians U, Roland ME, Stock PG, Carlson L, Benet LZ. Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients. Transplantation. 80: 13-7. PMID 16003227 DOI: 10.1097/01.Tp.0000165111.09687.4E |
0.325 |
|
2005 |
Benet LZ. There are no useful CYP3A probes that quantitatively predict the in vivo kinetics of other CYP3A substrates and no expectation that one will be found. Molecular Interventions. 5: 79-83. PMID 15821156 DOI: 10.1124/Mi.5.2.5 |
0.418 |
|
2005 |
Putnam WS, Woo JM, Huang Y, Benet LZ. Effect of the MDR1 C3435T variant and P-glycoprotein induction on dicloxacillin pharmacokinetics. Journal of Clinical Pharmacology. 45: 411-21. PMID 15778422 DOI: 10.1177/0091270004273492 |
0.71 |
|
2005 |
Wu CY, Benet LZ. Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharmaceutical Research. 22: 11-23. PMID 15771225 DOI: 10.1007/S11095-004-9004-4 |
0.462 |
|
2005 |
SUN H, HUANG Y, OKOCHI H, FRASSETTO L, BENET L. Uremic toxins inhibit hepatic uptake of eprosartan Clinical Pharmacology & Therapeutics. 77: P2-P2. DOI: 10.1016/J.Clpt.2004.11.012 |
0.335 |
|
2004 |
Lam JL, Benet LZ. Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of digoxin metabolism in primary rat hepatocytes versus microsomes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 1311-6. PMID 15483198 DOI: 10.1124/Dmd.32.11.1311 |
0.799 |
|
2004 |
Ikeno F, Lyons J, Kaneda H, Baluom M, Benet LZ, Rezaee M. Novel percutaneous adventitial drug delivery system for regional vascular treatment. Catheterization and Cardiovascular Interventions : Official Journal of the Society For Cardiac Angiography & Interventions. 63: 222-30. PMID 15390346 DOI: 10.1002/Ccd.20167 |
0.363 |
|
2004 |
Egge-Jacobsen W, Unger M, Niemann CU, Baluom M, Hirai S, Benet LZ, Christians U. Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors. Therapeutic Drug Monitoring. 26: 546-62. PMID 15385839 DOI: 10.1097/00007691-200410000-00014 |
0.366 |
|
2004 |
Christians U, Gottschalk S, Miljus J, Hainz C, Benet LZ, Leibfritz D, Serkova N. Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors. British Journal of Pharmacology. 143: 388-96. PMID 15339861 DOI: 10.1038/Sj.Bjp.0705939 |
0.301 |
|
2004 |
Kim WY, Benet LZ. P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharmaceutical Research. 21: 1284-93. PMID 15290871 DOI: 10.1023/B:Pham.0000033017.52484.81 |
0.517 |
|
2004 |
Sun H, Huang Y, Frassetto L, Benet LZ. Effects of uremic toxins on hepatic uptake and metabolism of erythromycin. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 1239-46. PMID 15286055 DOI: 10.1124/Dmd.104.000521 |
0.386 |
|
2004 |
Benet LZ, Cummins CL, Wu CY. Unmasking the dynamic interplay between efflux transporters and metabolic enzymes. International Journal of Pharmaceutics. 277: 3-9. PMID 15158963 DOI: 10.1016/J.Ijpharm.2002.12.002 |
0.654 |
|
2004 |
Serkova NJ, Christians U, Benet LZ. Biochemical mechanisms of cyclosporine neurotoxicity. Molecular Interventions. 4: 97-107. PMID 15087483 DOI: 10.1124/Mi.4.2.7 |
0.307 |
|
2004 |
Lau YY, Wu CY, Okochi H, Benet LZ. Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay. The Journal of Pharmacology and Experimental Therapeutics. 308: 1040-5. PMID 14634033 DOI: 10.1124/Jpet.103.061770 |
0.606 |
|
2004 |
Cummins CL, Jacobsen W, Christians U, Benet LZ. CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam. The Journal of Pharmacology and Experimental Therapeutics. 308: 143-55. PMID 14569063 DOI: 10.1124/Jpet.103.058065 |
0.673 |
|
2003 |
Frassetto L, Thai T, Aggarwal AM, Bucher P, Jacobsen W, Christians U, Benet LZ, Floren LC. Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects. Drug Metabolism and Pharmacokinetics. 18: 114-20. PMID 15618725 DOI: 10.2133/Dmpk.18.114 |
0.358 |
|
2003 |
Wu CY, Benet LZ. Disposition of tacrolimus in isolated perfused rat liver: influence of troleandomycin, cyclosporine, and gg918. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 1292-5. PMID 14570757 DOI: 10.1124/Dmd.31.11.1292 |
0.377 |
|
2003 |
Benet LZ, Cummins CL, Wu CY. Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data. Current Drug Metabolism. 4: 393-8. PMID 14529371 DOI: 10.2174/1389200033489389 |
0.679 |
|
2003 |
Li C, Olurinde MO, Hodges LM, Grillo MP, Benet LZ. Covalent binding of 2-phenylpropionyl-S-acyl-CoA thioester to tissue proteins in vitro. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 727-30. PMID 12756204 DOI: 10.1124/Dmd.31.6.727 |
0.551 |
|
2003 |
Cummins CL, Salphati L, Reid MJ, Benet LZ. In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model. The Journal of Pharmacology and Experimental Therapeutics. 305: 306-14. PMID 12649383 DOI: 10.1124/Jpet.102.044719 |
0.666 |
|
2003 |
Li C, Grillo MP, Benet LZ. In vivo mechanistic studies on the metabolic activation of 2-phenylpropionic acid in rat. The Journal of Pharmacology and Experimental Therapeutics. 305: 250-6. PMID 12649376 DOI: 10.1124/Jpet.102.043174 |
0.563 |
|
2003 |
Li C, Grillo MP, Benet LZ. In vitro studies on the chemical reactivity of 2,4-dichlorophenoxyacetyl-S-acyl-CoA thioester. Toxicology and Applied Pharmacology. 187: 101-9. PMID 12649042 DOI: 10.1016/S0041-008X(02)00043-1 |
0.5 |
|
2003 |
Putnam W, Desai D, Huang Y, Woo J, Benet L. The effect of induction conditions and MDR1 genotypes on dicloxacillin pharmacokinetics Clinical Pharmacology & Therapeutics. 73: P57-P57. DOI: 10.1016/S0009-9236(03)90568-6 |
0.672 |
|
2003 |
Benet LZ, Perotti BYT, Hardy L. Drug Absorption, Distribution, and Elimination Burger's Medicinal Chemistry and Drug Discovery. 633-647. DOI: 10.1002/0471266949.Bmc037 |
0.392 |
|
2002 |
Unger M, Holzgrabe U, Jacobsen W, Cummins C, Benet LZ. Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava). Planta Medica. 68: 1055-8. PMID 12494328 DOI: 10.1055/S-2002-36360 |
0.59 |
|
2002 |
Li C, Benet LZ, Grillo MP. Enantioselective covalent binding of 2-phenylpropionic Acid to protein in vitro in rat hepatocytes. Chemical Research in Toxicology. 15: 1480-7. PMID 12437340 DOI: 10.1021/Tx025600L |
0.51 |
|
2002 |
Putnam WS, Ramanathan S, Pan L, Takahashi LH, Benet LZ. Functional characterization of monocarboxylic acid, large neutral amino acid, bile acid and peptide transporters, and P-glycoprotein in MDCK and Caco-2 cells. Journal of Pharmaceutical Sciences. 91: 2622-35. PMID 12434407 DOI: 10.1002/Jps.10264 |
0.702 |
|
2002 |
Cummins CL, Wu CY, Benet LZ. Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein. Clinical Pharmacology and Therapeutics. 72: 474-89. PMID 12426511 DOI: 10.1067/Mcp.2002.128388 |
0.583 |
|
2002 |
Li C, Benet LZ, Grillo MP. Studies on the chemical reactivity of 2-phenylpropionic acid 1-O-acyl glucuronide and S-acyl-CoA thioester metabolites. Chemical Research in Toxicology. 15: 1309-17. PMID 12387630 DOI: 10.1021/Tx020013L |
0.52 |
|
2002 |
Christians U, Jacobsen W, Benet LZ, Lampen A. Mechanisms of clinically relevant drug interactions associated with tacrolimus. Clinical Pharmacokinetics. 41: 813-51. PMID 12190331 DOI: 10.2165/00003088-200241110-00003 |
0.424 |
|
2002 |
Susanto M, Benet LZ. Can the enhanced renal clearance of antibiotics in cystic fibrosis patients be explained by P-glycoprotein transport? Pharmaceutical Research. 19: 457-62. PMID 12033380 DOI: 10.1023/A:1015191511817 |
0.358 |
|
2002 |
Flanagan SD, Takahashi LH, Liu X, Benet LZ. Contributions of saturable active secretion, passive transcellular, and paracellular diffusion to the overall transport of furosemide across adenocarcinoma (Caco-2) cells. Journal of Pharmaceutical Sciences. 91: 1169-77. PMID 11948555 DOI: 10.1002/Jps.10099 |
0.32 |
|
2002 |
Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler PE, Litt L, Benet LZ, Leibfritz D, Christians U. Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 22: 342-52. PMID 11891440 DOI: 10.1097/00004647-200203000-00012 |
0.302 |
|
2002 |
Parasrampuria DA, Lantz MV, Birnbaum JL, Vincenti FG, Benet LZ. Effect of calcineurin inhibitor therapy on P-gp expression and function in lymphocytes of renal transplant patients: a preliminary evaluation. Journal of Clinical Pharmacology. 42: 304-11. PMID 11865967 DOI: 10.1177/00912700222011337 |
0.342 |
|
2002 |
Cummins CL, Jacobsen W, Benet LZ. Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4. The Journal of Pharmacology and Experimental Therapeutics. 300: 1036-45. PMID 11861813 DOI: 10.1124/Jpet.300.3.1036 |
0.654 |
|
2002 |
Putnam WS, Pan L, Tsutsui K, Takahashi L, Benet LZ. Comparison of bidirectional cephalexin transport across MDCK and caco-2 cell monolayers: interactions with peptide transporters. Pharmaceutical Research. 19: 27-33. PMID 11837697 DOI: 10.1023/A:1013647114152 |
0.691 |
|
2002 |
Flanagan SD, Cummins CL, Susanto M, Liu X, Takahashi LH, Benet LZ. Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2). Pharmacology. 64: 126-34. PMID 11834888 DOI: 10.1159/000056161 |
0.609 |
|
2001 |
Qiu Y, Benet LZ, Burlingame AL. Identification of hepatic protein targets of the reactive metabolites of the non-hepatotoxic regioisomer of acetaminophen, 3'-hydroxyacetanilide, in the mouse in vivo using two-dimensional gel electrophoresis and mass spectrometry Advances in Experimental Medicine and Biology. 500: 663-673. PMID 11765013 DOI: 10.1007/978-1-4615-0667-6_99 |
0.304 |
|
2001 |
Tsunoda SM, Harris RZ, Christians U, Velez RL, Freeman RB, Benet LZ, Warshaw A. Red wine decreases cyclosporine bioavailability. Clinical Pharmacology and Therapeutics. 70: 462-7. PMID 11719733 DOI: 10.1067/Mcp.2001.119814 |
0.411 |
|
2001 |
Cummins CL, Mangravite LM, Benet LZ. Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Pharmaceutical Research. 18: 1102-9. PMID 11587480 DOI: 10.1023/A:1010914624111 |
0.624 |
|
2001 |
Benet LZ, Cummins CL. The drug efflux-metabolism alliance: biochemical aspects. Advanced Drug Delivery Reviews. 50: S3-11. PMID 11576692 DOI: 10.1016/S0169-409X(01)00178-8 |
0.685 |
|
2001 |
Serkova N, Jacobsen W, Niemann CU, Litt L, Benet LZ, Leibfritz D, Christians U. Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain British Journal of Pharmacology. 133: 875-885. PMID 11454661 DOI: 10.1038/Sj.Bjp.0704142 |
0.327 |
|
2001 |
Kuhn B, Jacobsen W, Christians U, Benet LZ, Kollman PA. Metabolism of sirolimus and its derivative everolimus by cytochrome P450 3A4: insights from docking, molecular dynamics, and quantum chemical calculations. Journal of Medicinal Chemistry. 44: 2027-34. PMID 11384247 DOI: 10.1021/Jm010079Y |
0.316 |
|
2001 |
Parasrampuria DA, Lantz MV, Benet LZ. A human lymphocyte based Ex Vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function Pharmaceutical Research. 18: 39-44. PMID 11336351 DOI: 10.1023/A:1011070509191 |
0.38 |
|
2001 |
Zhang Y, Benet LZ. The gut as a barrier to drug absorption: Combined role of cytochrome P450 3A and P-glycoprotein Clinical Pharmacokinetics. 40: 159-168. PMID 11327196 DOI: 10.2165/00003088-200140030-00002 |
0.43 |
|
2001 |
Wacher VJ, Salphati L, Benet LZ. Active secretion and enterocytic drug metabolism barriers to drug absorption Advanced Drug Delivery Reviews. 46: 89-102. PMID 11259835 DOI: 10.1016/S0169-409X(00)00126-5 |
0.461 |
|
2001 |
Mancinelli LM, Frassetto L, Floren LC, Dressler D, Carrier S, Bekersky I, Benet LZ, Christians U. The pharmacokinetics and metabolic disposition of tacrolimus: A comparison across ethnic groups Clinical Pharmacology and Therapeutics. 69: 24-31. PMID 11180035 DOI: 10.1067/Mcp.2001.113183 |
0.313 |
|
2000 |
Boni JP, Korthbradley JM, Richards LS, Chiang ST, Hicks DR, Benet LZ. Chiral bioequivalence: Effect of absorption rate on racemic etodolac Clinical Pharmacokinetics. 39: 459-469. PMID 11192477 DOI: 10.2165/00003088-200039060-00006 |
0.389 |
|
2000 |
Christians U, First MR, Benet LZ. Recommendations for bioequivalence testing of cyclosporine generics revisited Therapeutic Drug Monitoring. 22: 330-345. PMID 10850403 DOI: 10.1097/00007691-200006000-00017 |
0.303 |
|
2000 |
Soldner A, Benet LZ, Mutschler E, Christians U. Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and Caco-2 cell monolayers British Journal of Pharmacology. 129: 1235-1243. PMID 10725273 DOI: 10.1038/Sj.Bjp.0703150 |
0.319 |
|
1999 |
Benet LZ, Izumi T, Zhang Y, Silverman JA, Wacher VJ. Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery Journal of Controlled Release. 62: 25-31. PMID 10518631 DOI: 10.1016/S0168-3659(99)00034-6 |
0.451 |
|
1999 |
Benet LZ. Relevance of pharmacokinetics in narrow therapeutic index drugs Transplantation Proceedings. 31: 1642-1644. PMID 10331032 DOI: 10.1016/S0041-1345(99)00083-4 |
0.412 |
|
1999 |
Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ. Grapefruit juice activates P-glycoprotein-mediated drug transport Pharmaceutical Research. 16: 478-485. PMID 10227700 DOI: 10.1023/A:1011902625609 |
0.401 |
|
1999 |
Hausen B, Boeke K, Berry GJ, Segarra I, Benet LZ, Christians U, Morris RE. Coadministration of neoral and the novel rapamycin analog, SDZ RAD, to rat lung allograft recipients: Potentiation of immunosuppressive efficacy and improvement of tolerability by staggered versus simultaneous treatment Transplantation. 67: 956-962. PMID 10221478 DOI: 10.1097/00007890-199904150-00005 |
0.379 |
|
1999 |
Salphati L, Benet LZ. Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: Involvement of cytochrome P4503A Xenobiotica. 29: 171-185. PMID 10199593 DOI: 10.1080/004982599238722 |
0.318 |
|
1999 |
Flanagan SD, Benet LZ. Net secretion of furosemide is subject to indomethacin inhibition, as observed in Caco-2 monolayers and excised rat jejunum Pharmaceutical Research. 16: 221-224. PMID 10100306 DOI: 10.1023/A:1018868123367 |
0.312 |
|
1999 |
Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ. Grapefruit juice exerts stimulatory effects on P-glycoprotein Clinical Pharmacology and Therapeutics. 65: 205. DOI: 10.1016/S0009-9236(99)80351-8 |
0.375 |
|
1999 |
Floren LC, Christians U, Zimmerman JJ, Neefe L, Schorer R, Rushworth D, Harper D, Renz J, Benet LZ. Sirolimus oral bioavailability increases ten-fold with concomitant ketoconazole Clinical Pharmacology and Therapeutics. 65: 159. DOI: 10.1016/S0009-9236(99)80167-2 |
0.301 |
|
1998 |
Tsunoda SM, Harris RZ, Mroczkowski PJ, Benet LZ. Preliminary evaluation of progestins as inducers of cytochrome P450 3A4 activity in postmenopausal women. Journal of Clinical Pharmacology. 38: 1137-43. PMID 11301566 DOI: 10.1177/009127009803801208 |
0.313 |
|
1998 |
Wacher VJ, Silverman JA, Zhang Y, Benet LZ. Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics Journal of Pharmaceutical Sciences. 87: 1322-1330. PMID 9811484 DOI: 10.1021/Js980082D |
0.41 |
|
1998 |
Benet LZ. Impact of intraindividual variability of drugs on therapeutic outcomes: Lessons from outside transplantation Transplantation Proceedings. 30: 1650-1651. PMID 9723227 DOI: 10.1016/S0041-1345(98)00376-5 |
0.312 |
|
1998 |
Salphati L, Benet LZ. Effects of ketoconazole on digoxin absorption and disposition in rat Pharmacology. 56: 308-313. PMID 9654217 DOI: 10.1159/000028214 |
0.323 |
|
1998 |
Qiu Y, Benet LZ, Burlingame AL. Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry Journal of Biological Chemistry. 273: 17940-17953. PMID 9651401 DOI: 10.1074/Jbc.273.28.17940 |
0.3 |
|
1998 |
Jang GR, Benet LZ. Antiprogestin-mediated inactivation of cytochrome P450 3A4 Pharmacology. 56: 150-157. PMID 9532615 DOI: 10.1159/000028193 |
0.383 |
|
1998 |
Mizuma T, Benet LZ, Lin ET. Preparative chromatography of furosemide 1-O-acyl-glucuronide from urine using micronized amberlite XAD-2 and its application to other 1-O-acyl-glucuronides Preparative Biochemistry and Biotechnology. 28: 37-47. PMID 9516641 DOI: 10.1080/10826069808010125 |
0.308 |
|
1997 |
Jang GR, Benet LZ. Antiprogestin pharmacodynamics, pharmacokinetics, and metabolism: Implications for their long-term use Journal of Pharmacokinetics and Biopharmaceutics. 25: 647-672. PMID 9697076 DOI: 10.1023/A:1025725716343 |
0.425 |
|
1997 |
Lown KS, Mayo RR, Leichtman AB, Hsiao HL, Turgeon DK, Schmiedlin-Ren P, Brown MB, Guo W, Rossi SJ, Benet LZ, Watkins PB. Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine Clinical Pharmacology and Therapeutics. 62: 248-260. PMID 9333100 DOI: 10.1016/S0009-9236(97)90027-8 |
0.375 |
|
1997 |
Floren LC, Bekersky I, Benet LZ, Mekki Q, Dressier D, Lee JW, Roberts JP, Hebert MF. Tacrolimus oral bioavailability doubles with coadministration of ketoconazole Clinical Pharmacology and Therapeutics. 62: 41-49. PMID 9246018 DOI: 10.1016/S0009-9236(97)90150-8 |
0.337 |
|
1996 |
Sambol NC, Chiang J, O'Conner M, Liu CY, Lin ET, Goodman AM, Benet LZ, Karam JH. Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin-dependent diabetes mellitus. Journal of Clinical Pharmacology. 36: 1012-21. PMID 8973990 DOI: 10.1177/009127009603601105 |
0.301 |
|
1996 |
Shah VP, Yacobi A, Barr WH, Benet LZ, Breimer D, Dobrinska MR, Endrenyi L, Fairweather W, Gillespie W, Gonzalez MA, Hooper J, Jackson A, Lesko LJ, Midha KK, Noonan PK, et al. Evaluation of orally administered highly variable drugs and drug formulations Pharmaceutical Research. 13: 1590-1594. PMID 8956322 DOI: 10.1023/A:1016468018478 |
0.406 |
|
1996 |
Jang GR, Wrighton SA, Benet LZ. Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes. Biochemical Pharmacology. 52: 753-61. PMID 8765473 DOI: 10.1016/0006-2952(96)00357-7 |
0.341 |
|
1996 |
Jaeger W, Benet LZ, Bornheim LM. Inhibition of cyclosporine and tetrahydrocannabinol metabolism by cannabidiol in mouse and human microsomes. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 26: 275-84. PMID 8730919 DOI: 10.3109/00498259609046707 |
0.366 |
|
1996 |
Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clinical Pharmacology and Therapeutics. 59: 297-303. PMID 8653992 DOI: 10.1016/S0009-9236(96)80007-5 |
0.397 |
|
1996 |
d'Uscio CH, Aweeka FT, Prueksaritanont T, Tomlanovich SJ, Gupta SK, Lantz MV, Gambertoglio JG, Garovoy MR, Benet LZ. Immunopharmacodynamic studies of cyclosporine in patients awaiting renal transplantation. Journal of Clinical Pharmacology. 35: 967-73. PMID 8568014 DOI: 10.1002/J.1552-4604.1995.Tb04012.X |
0.345 |
|
1996 |
Harris RZ, Benet LZ, Schwartz JB. Gender effects in pharmacokinetics and pharmacodynamics. Drugs. 50: 222-39. PMID 8521756 DOI: 10.2165/00003495-199550020-00003 |
0.409 |
|
1996 |
Benet LZ, Wu C, Hebert MF, Wacher VJ. Intestinal drug metabolism and antitransport processes: A potential paradigm shift in oral drug delivery Journal of Controlled Release. 39: 139-143. DOI: 10.1016/0168-3659(95)00147-6 |
0.45 |
|
1995 |
Gomez DY, Wacher VJ, Tomlanovich SJ, Hebert MF, Benet LZ. The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine. Clinical Pharmacology and Therapeutics. 58: 15-9. PMID 7628178 DOI: 10.1016/0009-9236(95)90067-5 |
0.358 |
|
1995 |
Wacher VJ, Wu CY, Benet LZ. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Molecular Carcinogenesis. 13: 129-34. PMID 7619215 DOI: 10.1002/Mc.2940130302 |
0.325 |
|
1995 |
Wu CY, Benet LZ, Hebert MF, Gupta SK, Rowland M, Gomez DY, Wacher VJ. Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine. Clinical Pharmacology and Therapeutics. 58: 492-7. PMID 7586942 DOI: 10.1016/0009-9236(95)90168-X |
0.373 |
|
1995 |
Zia-Amirhosseini P, Harris RZ, Brodsky FM, Benet LZ. Hypersensitivity to nonsteroidal anti-inflammatory drugs Nature Medicine. 1: 2-4. PMID 7584944 DOI: 10.1038/Nm0195-2B |
0.323 |
|
1995 |
Benet LZ, Zia-Amirhosseini P. Basic principles of pharmacokinetics. Toxicologic Pathology. 23: 115-23. PMID 7569664 DOI: 10.1177/019262339502300203 |
0.395 |
|
1995 |
Wacher VJ, Liu T, Roberts JP, Ascher NL, Benet LZ. Time course of cyclosporine and ist motabolites in blood, liver and spleen of naive Lewis rats: comparison with preliminary data obtained in transplanted animals. Biopharmaceutics & Drug Disposition. 16: 303-12. PMID 7548779 DOI: 10.1002/Bdd.2510160406 |
0.31 |
|
1995 |
Zia-Amirhosseini P, Ding A, Burlingame AL, McDonagh AF, Benet LZ. Synthesis and mass-spectrometric characterization of human serum albumins modified by covalent binding of two non-steroidal anti-inflammatory drugs: tolmetin and zomepirac. The Biochemical Journal. 431-5. PMID 7487878 DOI: 10.1042/Bj3110431 |
0.339 |
|
1995 |
Benet LZ, Goyan JE. Bioequivalence and Narrow Therapeutic Index Drugs Pharmacotherapy. 15: 433-440. DOI: 10.1002/J.1875-9114.1995.Tb04379.X |
0.386 |
|
1994 |
Zia-Amirhosseini P, Ojingwa JC, Spahn-Langguth H, McDonagh AF, Benet LZ. Enhanced covalent binding of tolmetin to proteins in humans after multiple dosing. Clinical Pharmacology and Therapeutics. 55: 21-7. PMID 8299313 DOI: 10.1038/Clpt.1994.5 |
0.324 |
|
1994 |
Benet LZ, Zech K. Pharmacokinetics--a relevant factor for the choice of a drug? Alimentary Pharmacology & Therapeutics. 25-32. PMID 8180291 DOI: 10.1111/J.1365-2036.1994.Tb00225.X |
0.443 |
|
1994 |
Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH. Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. Journal of Clinical Pharmacology. 34: 111-9. PMID 8163710 DOI: 10.1002/J.1552-4604.1994.Tb03974.X |
0.393 |
|
1994 |
Gumbleton M, Benet LZ. Simultaneous pharmacodynamic modeling of the non-steady-state effects of three oral doses of 1,3-glyceryl dinitrate upon blood pressure in healthy volunteers. Journal of Pharmacokinetics and Biopharmaceutics. 21: 515-32. PMID 8145129 DOI: 10.1007/Bf01059112 |
0.359 |
|
1994 |
Aweeka FT, Tomlanovich SJ, Prueksaritanont T, Gupta SK, Benet LZ. Pharmacokinetics of orally and intravenously administered cyclosporine in pre-kidney transplant patients. Journal of Clinical Pharmacology. 34: 60-7. PMID 8132853 DOI: 10.1002/J.1552-4604.1994.Tb03967.X |
0.334 |
|
1994 |
Ojingwa JC, Spahn-Langguth H, Benet LZ. Reversible binding of tolmetin, zomepirac, and their glucuronide conjugates to human serum albumin and plasma. Journal of Pharmacokinetics and Biopharmaceutics. 22: 19-40. PMID 8027947 DOI: 10.1007/Bf02353408 |
0.31 |
|
1994 |
Han C, Jung P, Sanders SW, Lin ET, Benet LZ. Pharmacokinetics of nitroglycerin and its four metabolites during nitroglycerin transdermal administration. Biopharmaceutics & Drug Disposition. 15: 179-83. PMID 8011969 DOI: 10.1002/Bdd.2510150210 |
0.394 |
|
1994 |
Perotti BY, Prueksaritanont T, Benet LZ. HPLC assay for FK 506 and two metabolites in isolated rat hepatocytes and rat liver microsomes. Pharmaceutical Research. 11: 844-7. PMID 7524055 DOI: 10.1023/A:1018977707960 |
0.398 |
|
1993 |
Spahn-Langguth H, Benet LZ. Microsomal acyl glucuronidation: enzyme-kinetic studies with labile glucuronides. Pharmacology. 46: 268-73. PMID 8488171 DOI: 10.1159/000139054 |
0.316 |
|
1993 |
Ding A, Ojingwa JC, McDonagh AF, Burlingame AL, Benet LZ. Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America. 90: 3797-801. PMID 8483897 DOI: 10.1073/Pnas.90.9.3797 |
0.301 |
|
1993 |
Benet LZ, Spahn-Langguth H, Iwakawa S, Volland C, Mizuma T, Mayer S, Mutschler E, Lin ET. Predictability of the covalent binding of acidic drugs in man. Life Sciences. 53: PL141-6. PMID 8350674 DOI: 10.1016/0024-3205(93)90279-C |
0.404 |
|
1993 |
Mayer S, Mutschler E, Benet LZ, Sphahn-Langguth H. In vitro and in vivo irreversible plasma protein binding of beclobric acid enantiomers. Chirality. 5: 120-5. PMID 8338721 DOI: 10.1002/Chir.530050304 |
0.367 |
|
1993 |
Lee FW, Hu J, Metzler CH, Benet LZ. Nitroglycerin dinitrate metabolites do not affect the pharmacokinetics and pharmacodynamics of nitroglycerin in the dog: A preliminary report Journal of Pharmacokinetics and Biopharmaceutics. 21: 163-173. PMID 8229678 DOI: 10.1007/Bf01059768 |
0.341 |
|
1993 |
Benet LZ. Pharmacokinetics of sustained-release etodolac. Rheumatology International. 13: S3-5. PMID 8210922 DOI: 10.1007/Bf00290277 |
0.363 |
|
1993 |
Lee FW, Salmonson T, Benet LZ. Pharmacokinetics and pharmacodynamics of nitroglycerin and its dinitrate metabolites in conscious dogs: Intravenous infusion studies Journal of Pharmacokinetics and Biopharmaceutics. 21: 533-550. PMID 8145130 DOI: 10.1007/Bf01059113 |
0.318 |
|
1993 |
Haefeli WE, Gumbleton M, Benet LZ, Hoffman BB, Blaschke TF. Comparison of vasodilatory responses to nitroglycerin and its dinitrate metabolites in human veins. Clinical Pharmacology and Therapeutics. 52: 590-6. PMID 1458768 DOI: 10.1038/Clpt.1992.196 |
0.345 |
|
1992 |
Benet LZ. Safety and pharmacokinetics: colloidal bismuth subcitrate. Scandinavian Journal of Gastroenterology. Supplement. 185: 29-35. PMID 1957122 DOI: 10.3109/00365529109093217 |
0.359 |
|
1992 |
Volland C, Benet LZ. In vitro enantioselective glucuronidation of fenoprofen. Pharmacology. 43: 53-60. PMID 1775510 DOI: 10.1159/000138828 |
0.319 |
|
1992 |
Lau DT, Benet LZ. Effects of sulfobromophthalein and ethacrynic acid on glyceryl trinitrate relaxation. Biochemical Pharmacology. 43: 2247-54. PMID 1599510 DOI: 10.1016/0006-2952(92)90184-K |
0.309 |
|
1992 |
Prueksaritanont T, Koike M, Hoener BA, Benet LZ. Transport and metabolism of cyclosporine in isolated rat hepatocytes. The effects of lipids. Biochemical Pharmacology. 43: 1997-2006. PMID 1596287 DOI: 10.1016/0006-2952(92)90643-W |
0.355 |
|
1992 |
Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH. Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. Clinical Pharmacology and Therapeutics. 51: 465-73. PMID 1563216 DOI: 10.1038/Clpt.1992.47 |
0.393 |
|
1992 |
Higo N, Hinz RS, Lau DT, Benet LZ, Guy RH. Cutaneous metabolism of nitroglycerin in vitro. I. Homogenized versus intact skin. Pharmaceutical Research. 9: 187-90. PMID 1553339 DOI: 10.1023/A:1018925004345 |
0.311 |
|
1992 |
Han C, Gumbleton M, Lau DT, Benet LZ. Improved gas chromatographic assay for the simultaneous determination of nitroglycerin and its mono- and dinitrate metabolites. Journal of Chromatography. 579: 237-45. PMID 1429971 DOI: 10.1016/0378-4347(92)80387-6 |
0.329 |
|
1992 |
Hebert MF, Roberts JP, Prueksaritanont T, Benet LZ. Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction. Clinical Pharmacology and Therapeutics. 52: 453-7. PMID 1424418 DOI: 10.1038/Clpt.1992.171 |
0.383 |
|
1992 |
Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH. Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. Journal of Pharmaceutical Sciences. 81: 605-10. PMID 1355792 DOI: 10.1002/Jps.2600810630 |
0.381 |
|
1992 |
Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, H. Rodman J, Sanathanan L, Schentag JJ, Shah VP, Sheiner LB, Skelly JP, et al. Opportunities for integration of pharmacokinetics, pharmacodynamics and toxicokinetics in rational drug development International Journal of Pharmaceutics. 82: 9-19. DOI: 10.1016/0378-5173(92)90066-B |
0.398 |
|
1991 |
Volland C, Sun H, Benet LZ. Stereoselective analysis of fenoprofen and its metabolites. Journal of Chromatography. 534: 127-38. PMID 2094699 DOI: 10.1016/S0378-4347(00)82155-6 |
0.339 |
|
1991 |
Hammarlund-Udenaes M, Benet LZ. Prednisone and prednisolone interconversion in the rabbit utilizing unbound concentrations. Biopharmaceutics & Drug Disposition. 12: 467-77. PMID 1932610 DOI: 10.1002/Bdd.2510120608 |
0.318 |
|
1991 |
Benet LZ. Rho Chi Lecture. Ideals and innovation: drugs, generics, the FDA, and the pharmacist. Dicp : the Annals of Pharmacotherapy. 25: 427-30. PMID 1926916 DOI: 10.1177/106002809102500419 |
0.375 |
|
1991 |
Williams RL, Thakker KM, John V, Lin ET, Liang-Gee W, Benet LZ. Nitroglycerin absorption from transdermal systems: formulation effects and metabolite concentrations. Pharmaceutical Research. 8: 744-9. PMID 1905809 DOI: 10.1023/A:1015802101272 |
0.406 |
|
1991 |
Lau DT, Gumbleton M, Labisch C, Benet LZ. Pharmacokinetic studies of the nitroglycerin metabolites, 1,2- and 1,3- glyceryl dinitrates, in the rat. Biopharmaceutics & Drug Disposition. 12: 215-22. PMID 1905575 DOI: 10.1002/Bdd.2510120306 |
0.356 |
|
1991 |
Gumbleton M, Benet LZ. Drug metabolism and laboratory anesthetic protocols in the rat: examination of antipyrine pharmacokinetics. Pharmaceutical Research. 8: 544-6. PMID 1871056 DOI: 10.1023/A:1015827917684 |
0.402 |
|
1991 |
Hale VG, Aizawa K, Sheiner LB, Benet LZ. Disposition of prednisone and prednisolone in the perfused rabbit liver: Modeling hepatic metabolic processes Journal of Pharmacokinetics and Biopharmaceutics. 19: 597-614. PMID 1783993 DOI: 10.1007/Bf01062965 |
0.389 |
|
1991 |
Snah VP, Flynn GL, Guy RH, Maibach HI, Schaefer H, Skelly JP, Wester RC, Yacobi A, Anderson BD, Andersen KE, Barry BW, Behl CR, Benet LZ, Bronaugh RL, Bucks DAW, et al. In vivo percutaneous penetration/absorption. Sponsored by the American Association of Pharmaceutical Scientist, U.S. Food and Drug Administration, American Academy of Dermatology, Skin Pharmacology Society and the U.S. Army Environmental Hygiene Agency May 1-3, 1989, Washington, DC International Journal of Pharmaceutics. 74: 1-8. DOI: 10.1016/0378-5173(91)90402-A |
0.358 |
|
1990 |
Gupta SK, Manfro RC, Tomlanovich SJ, Gambertoglio JG, Garovoy MR, Benet LZ. Effect of food on the pharmacokinetics of cyclosporine in healthy subjects following oral and intravenous administration. Journal of Clinical Pharmacology. 30: 643-53. PMID 2391396 DOI: 10.1002/J.1552-4604.1990.Tb01868.X |
0.321 |
|
1990 |
Williams RL, Lin ET, Liang-Gee W, Blume CD, Benet LZ. Absorption and disposition of a new low-dose combination formulation of hydrochlorothiazide and triamterene. Biopharmaceutics & Drug Disposition. 11: 233-43. PMID 2328310 DOI: 10.1002/Bdd.2510110308 |
0.335 |
|
1990 |
Gupta SK, Benet LZ. High-fat meals increase the clearance of cyclosporine. Pharmaceutical Research. 7: 46-8. PMID 2300535 DOI: 10.1023/A:1015831408425 |
0.368 |
|
1990 |
Nakashima E, Rigod JF, Lin ET, Benet LZ. Pharmacokinetics of nitroglycerin and its dinitrate metabolites over a thirtyfold range of oral doses. Clinical Pharmacology and Therapeutics. 47: 592-8. PMID 2111749 DOI: 10.1038/Clpt.1990.80 |
0.32 |
|
1990 |
Wang LH, Rudolph AM, Benet LZ. Comparative Study of Acetaminophen Disposition in Sheep at
Three Developmental Stages: the Fetal, Neonatal and Adult Periods Developmental Pharmacology and Therapeutics. 14: 161-179. DOI: 10.1159/000480915 |
0.361 |
|
1990 |
Gloff CA, Benet LZ. Pharmacokinetics and protein therapeutics Advanced Drug Delivery Reviews. 4: 359-386. DOI: 10.1016/0169-409X(90)90027-P |
0.333 |
|
1990 |
Skelly JP, Amidon GL, Barr WH, Benet LZ, Carter JE, Robinson JR, Shah VP, Yacobi A. In vitro and in vivo testing and correlation for oral controlled/ modified release dosage forms. report of the 2nd workshop held December 1988, Washington, DC. U.S.A. Journal of Controlled Release. 14: 95-106. DOI: 10.1016/0168-3659(90)90064-Z |
0.368 |
|
1989 |
Gloff CA, Benet LZ. Differential effects of the degree of renal damage on p-aminohippuric acid and inulin clearances in rats. Journal of Pharmacokinetics and Biopharmaceutics. 17: 169-77. PMID 2795454 DOI: 10.1007/Bf01059026 |
0.305 |
|
1989 |
Spahn H, Spahn I, Benet LZ. Probenecid-induced changes in the clearance of carprofen enantiomers: a preliminary study. Clinical Pharmacology and Therapeutics. 45: 500-5. PMID 2721105 DOI: 10.1038/Clpt.1989.64 |
0.362 |
|
1989 |
Watari N, Benet LZ. Determination of mean input time, mean residence time, and steady-state volume of distribution with multiple drug inputs. Journal of Pharmacokinetics and Biopharmaceutics. 17: 593-9. PMID 2614687 DOI: 10.1007/Bf01071351 |
0.329 |
|
1989 |
Gupta S, Benet L. HPLC Measurement of Cyclosporine in Blood Plasma and Urine and Simultaneous Measurement of its Four Metabolites in Blood Journal of Liquid Chromatography & Related Technologies. 12: 1451-1462. DOI: 10.1080/01483918908049516 |
0.304 |
|
1988 |
Schwartz JB, Upton RA, Lin ET, Williams RL, Benet LZ. Effect of cimetidine or ranitidine administration on nifedipine pharmacokinetics and pharmacodynamics. Clinical Pharmacology and Therapeutics. 43: 673-80. PMID 3378388 DOI: 10.1038/Clpt.1988.94 |
0.325 |
|
1988 |
Gawienowski M, Benet LZ, Fleckenstein L, Lin ET. Ion-paired liquid chromatographic method for the analysis of blood and plasma for the antimalarial drug halofantrine and its putative mono-debutylated metabolite. Journal of Chromatography. 430: 412-9. PMID 3235515 DOI: 10.1016/S0378-4347(00)83179-5 |
0.345 |
|
1988 |
Gloff CA, Mamelok RD, Benet LZ. Organic anion transport by basal-lateral membranes: effect of PAH and furosemide on each other's transport. Pharmacology. 37: 268-76. PMID 3194444 DOI: 10.1159/000138476 |
0.302 |
|
1988 |
Yu DK, Williams RL, Benet LZ, Lin ET, Giesing DH. Pharmacokinetics of nitroglycerin and metabolites in humans following oral dosing. Biopharmaceutics & Drug Disposition. 9: 557-65. PMID 3147725 DOI: 10.1002/Bod.2510090606 |
0.351 |
|
1988 |
Lee FW, Watari N, Rigod J, Benet LZ. Simultaneous determination of nitroglycerin and its dinitrate metabolites by capillary gas chromatography with electron-capture detection. Journal of Chromatography. 426: 259-66. PMID 3134385 DOI: 10.1016/S0378-4347(00)81954-4 |
0.302 |
|
1988 |
Nakashima E, Noonan PK, Benet LZ. Transdermal bioavailability and first-pass skin metabolism: a preliminary evaluation with nitroglycerin. Journal of Pharmacokinetics and Biopharmaceutics. 15: 423-37. PMID 3119815 DOI: 10.1007/Bf01066522 |
0.347 |
|
1987 |
Williams RL, Mordenti J, Upton RA, Lin ET, Gee WL, Blume CD, Benet LZ. Effects of formulation and food on the absorption of hydrochlorothiazide and triamterene or amiloride from combination diuretic products. Pharmaceutical Research. 4: 348-52. PMID 3508542 DOI: 10.1023/A:1016409606936 |
0.308 |
|
1987 |
Noonan PK, Benet LZ. Variable glyceryl dinitrate formation as a function of route of nitroglycerin administration. Clinical Pharmacology and Therapeutics. 42: 273-7. PMID 3113806 DOI: 10.1038/Clpt.1987.146 |
0.358 |
|
1987 |
Ferraiolo BL, Halldin MM, Asscher Y, Akita Y, Melmon KL, Benet LZ, Castagnoli N. Pharmacokinetics and excretion of unique beta-adrenergic agonists. Pharmacology. 34: 157-66. PMID 2884679 DOI: 10.1159/000138265 |
0.347 |
|
1987 |
Yturralde O, Lee R, Benet LZ, Fleckenstein L, Lin ETL. Ion-Paired Liquid Chromatographic Method for the Analysis of Pyridostigmine in Plasma Journal of Liquid Chromatography. 10: 2231-2246. DOI: 10.1080/01483918708068907 |
0.331 |
|
1986 |
Sörgel F, Ettinger B, Benet LZ. Metabolic fate and solubility of triamterene--not an explanation for triamterene nephrolithiasis. Journal of Pharmaceutical Sciences. 75: 129-32. PMID 3958920 DOI: 10.1002/Jps.2600750205 |
0.359 |
|
1986 |
Legler UF, Benet LZ. Marked alterations in dose-dependent prednisolone kinetics in women taking oral contraceptives. Clinical Pharmacology and Therapeutics. 39: 425-9. PMID 3956058 DOI: 10.1038/Clpt.1986.66 |
0.348 |
|
1986 |
Smith PC, McDonagh AF, Benet LZ. Irreversible binding of zomepirac to plasma protein in vitro and in vivo. The Journal of Clinical Investigation. 77: 934-9. PMID 3949982 DOI: 10.1172/Jci112392 |
0.38 |
|
1986 |
Williams RL, Thornhill MD, Upton RA, Blume C, Clark TS, Lin E, Benet LZ. Absorption and disposition of two combination formulations of hydrochlorothiazide and triamterene: influence of age and renal function. Clinical Pharmacology and Therapeutics. 40: 226-32. PMID 3731685 DOI: 10.1038/Clpt.1986.167 |
0.313 |
|
1986 |
Varughese A, Brater DC, Benet LZ, Lee CS. Ethambutol kinetics in patients with impaired renal function. The American Review of Respiratory Disease. 134: 34-8. PMID 3729159 DOI: 10.1164/Arrd.1986.134.1.34 |
0.302 |
|
1986 |
Shi RJ, Benet LZ, Lin ET. High-performance liquid chromatographic assay of basic amine drugs in plasma and urine using a silica gel column and an aqueous mobile phase. I. Amiloride. Journal of Chromatography. 377: 399-404. PMID 3711234 DOI: 10.1016/S0378-4347(00)80800-2 |
0.336 |
|
1986 |
Noonan PK, Benet LZ. The bioavailability of oral nitroglycerin. Journal of Pharmaceutical Sciences. 75: 241-3. PMID 3084757 DOI: 10.1002/Jps.2600750306 |
0.36 |
|
1985 |
Sörgel F, Ettinger B, Benet LZ. The true composition of kidney stones passed during triamterene therapy. The Journal of Urology. 134: 871-3. PMID 4057369 DOI: 10.1016/S0022-5347(17)47497-0 |
0.309 |
|
1985 |
Noonan PK, Williams RL, Benet LZ. Dose dependent pharmacokinetics of nitroglycerin after multiple intravenous infusions in healthy volunteers. Journal of Pharmacokinetics and Biopharmaceutics. 13: 143-57. PMID 3932639 DOI: 10.1007/Bf01059395 |
0.358 |
|
1985 |
Sheiner LB, Benet LZ. Premarketing observational studies of population pharmacokinetics of new drugs Clinical Pharmacology and Therapeutics. 38: 481-487. PMID 3931953 DOI: 10.1038/Clpt.1985.212 |
0.363 |
|
1985 |
Noonan PK, Benet LZ. Incomplete and delayed bioavailability of sublingual nitroglycerin. The American Journal of Cardiology. 55: 184-7. PMID 3917598 DOI: 10.1016/0002-9149(85)90325-X |
0.386 |
|
1985 |
Smith PC, Langendijk PN, Bosso JA, Benet LZ. Effect of probenecid on the formation and elimination of acyl glucuronides: studies with zomepirac. Clinical Pharmacology and Therapeutics. 38: 121-7. PMID 3874742 DOI: 10.1038/Clpt.1985.146 |
0.404 |
|
1985 |
Benet LZ. Pharmacokinetics and metabolism of bepridil. The American Journal of Cardiology. 55: 8C-13C. PMID 3872057 DOI: 10.1016/0002-9149(85)90799-4 |
0.438 |
|
1984 |
Chiang CW, Benet LZ. Dose-dependent kinetics of probenecid in rhesus monkeys--infusion studies. Pharmacology. 28: 181-7. PMID 6728896 DOI: 10.1159/000137960 |
0.377 |
|
1984 |
Meister W, Benowitz NL, Benet LZ. Unchanged absorption of digoxin tablets in patients with cardiac failure. Pharmacology. 28: 90-4. PMID 6709691 DOI: 10.1159/000137948 |
0.327 |
|
1984 |
Langendijk PN, Smith PC, Hasegawa J, Benet LZ. Simultaneous determination of zomepirac and its major metabolite zomepirac glucuronide in human plasma and urine. Journal of Chromatography. 307: 371-9. PMID 6610684 DOI: 10.1016/S0378-4347(00)84108-0 |
0.307 |
|
1984 |
Upton RA, Williams RL, Lin ET, Gee WL, Blume CD, Benet LZ. Absence of a significant pharmacokinetic interaction between hydrochlorothiazide and triamterene when coadministered. Journal of Pharmacokinetics and Biopharmaceutics. 12: 575-86. PMID 6533293 DOI: 10.1007/Bf01059553 |
0.423 |
|
1984 |
Blume CD, Williams RL, Upton RA, Lin ET, Benet LZ. Bioequivalence study of a new tablet formulation of triamterene and hydrochlorothiazide. The American Journal of Medicine. 77: 59-61. PMID 6496560 DOI: 10.1016/S0002-9343(84)80009-1 |
0.368 |
|
1984 |
Noonan PK, Kanfer I, Riegelman S, Benet LZ. Determination of picogram nitroglycerin plasma concentrations using capillary gas chromatography with on-column injection. Journal of Pharmaceutical Sciences. 73: 923-7. PMID 6432997 DOI: 10.1002/Jps.2600730715 |
0.309 |
|
1983 |
O'Neill PJ, Yorgey KA, Renzi NL, Williams RL, Benet LZ. Disposition of zomepirac sodium in man. Journal of Clinical Pharmacology. 22: 470-6. PMID 7174855 DOI: 10.1002/J.1552-4604.1982.Tb02637.X |
0.357 |
|
1983 |
Park GB, Kershner RP, Angellotti J, Williams RL, Benet LZ, Edelson J. Oral bioavailability and intravenous pharmacokinetics of amrinone in humans. Journal of Pharmaceutical Sciences. 72: 817-9. PMID 6886991 DOI: 10.1002/Jps.2600720726 |
0.324 |
|
1983 |
Smith DE, Benet LZ. Plasma protein binding of furosemide in kidney transplant patients. Journal of Pharmacokinetics and Biopharmaceutics. 10: 663-74. PMID 6763626 DOI: 10.1007/Bf01062547 |
0.305 |
|
1983 |
Smith DE, Benet LZ. Biotransformation of furosemide in kidney transplant patients. European Journal of Clinical Pharmacology. 24: 787-90. PMID 6350024 DOI: 10.1007/Bf00607088 |
0.35 |
|
1983 |
Baughman RA, Sorgel F, Mico BA, Benet LZ. Dose-dependent bioavailability of prazosin in beagle dogs Journal of Cardiovascular Pharmacology. 5: 613-617. PMID 6193359 DOI: 10.1097/00005344-198307000-00016 |
0.337 |
|
1982 |
Gustafson JH, Benet LZ. Saturable kinetics of intravenous chlorothiazide in the rhesus monkey. Journal of Pharmacokinetics and Biopharmaceutics. 9: 461-76. PMID 7310644 DOI: 10.1007/Bf01060889 |
0.346 |
|
1982 |
Hasegawa J, Lin ET, Williams RL, Sörgel F, Benet LZ. Pharmacokinetics of triamterene and its metabolite in man. Journal of Pharmacokinetics and Biopharmaceutics. 10: 507-23. PMID 7166735 DOI: 10.1007/Bf01059034 |
0.365 |
|
1982 |
Legler UF, Frey FJ, Benet LZ. Prednisolone clearance at steady state in man. The Journal of Clinical Endocrinology and Metabolism. 55: 762-7. PMID 7107818 DOI: 10.1210/Jcem-55-4-762 |
0.326 |
|
1982 |
Williams RL, Blume CD, Lin ET, Holford NH, Benet LZ. Relative bioavailability of chlorthalidone in humans: adverse influence of polyethylene glycol. Journal of Pharmaceutical Sciences. 71: 533-5. PMID 7097499 DOI: 10.1002/Jps.2600710514 |
0.302 |
|
1982 |
Williams RL, Davies RO, Berman RS, Holmes GI, Huber P, Gee WL, Lin ET, Benet LZ. Hydrochlorothiazide pharmacokinetics and pharmacologic effect: the influence of indomethacin. Journal of Clinical Pharmacology. 22: 32-41. PMID 7061724 DOI: 10.1002/J.1552-4604.1982.Tb05705.X |
0.394 |
|
1982 |
Benet LZ, Frey FJ, Amend WJC, Lozada F. Endogenous and exogenous glucocorticoids in cushingoid patients Drug Intelligence and Clinical Pharmacy. 16: 863-868. PMID 6756849 DOI: 10.1177/106002808201601109 |
0.313 |
|
1982 |
Frey FJ, Gambertoglio JG, Frey BM, Benet LZ, Amend WJ. Nonlinear plasma protein binding and haemodialysis clearance of prednisolone. European Journal of Clinical Pharmacology. 23: 65-74. PMID 6751835 DOI: 10.1007/Bf01061379 |
0.334 |
|
1982 |
Frey BM, Frey FJ, Holford NHG, Lozada F, Benet LZ. Prednisolone pharmacodynamics assessed by inhibition of the mixed lymphocyte reaction Transplantation. 33: 578-584. PMID 6213074 DOI: 10.1097/00007890-198206000-00002 |
0.333 |
|
1981 |
Lee CS, Brater DC, Gambertoglio JG, Benet LZ. Disposition kinetics of ethambutol in man. Journal of Pharmacokinetics and Biopharmaceutics. 8: 335-46. PMID 7431225 DOI: 10.1007/Bf01059382 |
0.304 |
|
1981 |
Chiang CW, Benet LZ. Dose-dependent kinetics of probenecid in rhesus monkeys - intravenous bolus studies Pharmacology. 23: 326-336. PMID 7312942 DOI: 10.1159/000137568 |
0.34 |
|
1981 |
Williams RL, Furst DE, Mandel HG, Nicoll D, Konikoff JJ, Benet LZ. Effects of indomethacin and carprofen on renal homeostasis in rheumatoid arthritis patients and in healthy individuals. Journal of Clinical Pharmacology. 21: 493-500. PMID 7037867 DOI: 10.1002/J.1552-4604.1981.Tb05656.X |
0.37 |
|
1981 |
Frey FJ, Amend WJC, Lozada F, Frey BM, Holford NHG, Benet LZ. Pharmacokinetics of prednisolone and endogenous hydrocortisone levels in cushingoid and non-cushingoid patients European Journal of Clinical Pharmacology. 21: 235-242. PMID 7032949 DOI: 10.1007/Bf00627926 |
0.331 |
|
1981 |
Frey FJ, Amend WJC, Lozada F, Benet LZ. Endogenous hydrocortisone, a possible factor contributing to the genesis of cushingoid habitus in patients on prednisone Journal of Clinical Endocrinology and Metabolism. 53: 1076-1080. PMID 7026594 DOI: 10.1210/Jcem-53-5-1076 |
0.309 |
|
1981 |
Smith DE, Gambertoglio JG, Vincenti F, Benet LZ. Furosemide kinetics and dynamics after kidney transplant. Clinical Pharmacology and Therapeutics. 30: 105-13. PMID 7016396 DOI: 10.1038/Clpt.1981.134 |
0.323 |
|
1981 |
Sheiner LB, Benet LZ, Pagliaro LA. A standard approach to compiling clinical pharmacokinetic data Journal of Pharmacokinetics and Biopharmaceutics. 9: 59-127. PMID 7014827 DOI: 10.1007/Bf01059343 |
0.335 |
|
1980 |
Baughman RA, Arnold S, Benet LZ, Lin ET, Chatterjee K, Williams RL. Altered prazosin pharmacokinetics in congestive heart failure. European Journal of Clinical Pharmacology. 17: 425-8. PMID 7398734 DOI: 10.1007/Bf00570159 |
0.339 |
|
1980 |
Smith DE, Gee WL, Brater DC, Lin ET, Benet LZ. Preliminary evaluation of furosemide-probenecid interaction in humans. Journal of Pharmaceutical Sciences. 69: 571-5. PMID 7381747 DOI: 10.1002/Jps.2600690526 |
0.347 |
|
1980 |
Lee CS, Marbury TC, Benet LZ. Clearance calculations in hemodialysis: application to blood, plasma, and dialysate measurements for ethambutol. Journal of Pharmacokinetics and Biopharmaceutics. 8: 69-81. PMID 7381692 DOI: 10.1007/Bf01059449 |
0.361 |
|
1980 |
Williams RL, Benet LZ. Drug pharmacokinetics in cardiac and hepatic disease Annual Review of Pharmacology and Toxicology. 20: 389-413. PMID 6992701 DOI: 10.1146/Annurev.Pa.20.040180.002133 |
0.434 |
|
1980 |
Gambertoglio JG, Amend WJC, Benet LZ. Pharmacokinetics and bioavailability of prednisone and prednisolone in healthy volunteers and patients: A review Journal of Pharmacokinetics and Biopharmaceutics. 8: 1-52. PMID 6991663 DOI: 10.1007/Bf01059447 |
0.309 |
|
1980 |
Smith DE, Benet LZ. Relationship between urinary excretion rate, steady-state plasma levels and diuretic response of furosemide in the rat. Pharmacology. 19: 301-6. PMID 549032 DOI: 10.1159/000137329 |
0.337 |
|
1980 |
Greither A, Goldman S, Edelen JS, Benet LZ, Cohn K. Pharmacokinetics of furosemide in patients with congestive heart failure. Pharmacology. 19: 121-31. PMID 523503 DOI: 10.1159/000137299 |
0.377 |
|
1980 |
Ding TL, Benet LZ. Determination of 6-mercaptopurine and azathioprine in plasma by high-performance liquid chromatography. Journal of Chromatography. 163: 281-8. PMID 120373 DOI: 10.1016/S0378-4347(00)81415-2 |
0.302 |
|
1980 |
Øie S, Benet LZ. Chapter 29. Altered Drug Disposition in Disease States Annual Reports in Medicinal Chemistry. 15: 277-287. DOI: 10.1016/S0065-7743(08)60390-5 |
0.408 |
|
1979 |
Benet LZ. Effect of route of administration and distribution on drug action. Journal of Pharmacokinetics and Biopharmaceutics. 6: 559-85. PMID 731418 DOI: 10.1007/Bf01062110 |
0.434 |
|
1979 |
Till AE, Benet LZ. Pseudoephedrine pharmacokinetics in the rat using a microanalysis technique. Pharmacology. 18: 306-10. PMID 493335 DOI: 10.1159/000137270 |
0.323 |
|
1979 |
Smith DE, Brater DC, Lin ET, Benet LZ. Attenuation of furosemide's diuretic effect by indomethacin: pharmacokinetic evaluation. Journal of Pharmacokinetics and Biopharmaceutics. 7: 265-74. PMID 480148 DOI: 10.1007/Bf01060017 |
0.338 |
|
1979 |
Benet LZ. Pharmacokinetics/pharmacodynamics of furosemide in man: a review. Journal of Pharmacokinetics and Biopharmaceutics. 7: 1-27. PMID 458552 DOI: 10.1007/Bf01059438 |
0.313 |
|
1979 |
Frey FJ, Frey BM, Benet LZ. Liquid-chromatographic measurement of endogenous and exogenous glucocorticoids in plasma. Clinical Chemistry. 25: 1944-1947. DOI: 10.1093/Clinchem/25.11.1944 |
0.328 |
|
1978 |
Aziz NS, Gambertoglio JG, Lin ET, Grausz H, Benet LZ. Pharmacokinetics of cefamandole using a HPLC assay. Journal of Pharmacokinetics and Biopharmaceutics. 6: 153-64. PMID 671221 DOI: 10.1007/Bf01117449 |
0.324 |
|
1978 |
Lee CS, Benet LZ. Micro and macro GLC determination of ethambutol in biological fluids. Journal of Pharmaceutical Sciences. 67: 470-3. PMID 641750 DOI: 10.1002/Jps.2600670407 |
0.303 |
|
1978 |
Stalker NE, Gambertoglio JG, Fukumitsu CJ, Naughton JL, Benet LZ. Acute massive chloral hydrate intoxication treated with hemodialysis: a clinical pharmacokinetic analysis. Journal of Clinical Pharmacology. 18: 136-42. PMID 624775 DOI: 10.1002/J.1552-4604.1978.Tb02434.X |
0.301 |
|
1977 |
Lee CS, Gambertoglio JG, Brater DC, Benet LZ. Kinetics of oral ethambutol in the normal subject. Clinical Pharmacology and Therapeutics. 22: 615-21. PMID 410579 DOI: 10.1002/Cpt1977225Part1615 |
0.336 |
|
1976 |
Galeazzi RL, Benet LZ. Inappropriate use of the law of corresponding areas to calculate the time course of absorption for multicompartmental systems. Journal of Pharmacokinetics and Biopharmaceutics. 4: 43-56. PMID 1271239 DOI: 10.1007/Bf01271443 |
0.383 |
|
1976 |
Pagliaro LA, Benet LZ. Critical compilation of terminal half-lives, percent excreted unchanged, and changes of half-life in renal and hepatic dysfunction for studies in humans with references. Journal of Pharmacokinetics and Biopharmaceutics. 3: 333-83. PMID 1107513 DOI: 10.1007/Bf01082306 |
0.312 |
|
1976 |
Galeazzi RL, Benet LZ, Sheiner LB. Relationship between the pharmacokinetics and pharmacodynamics of procainamide Clinical Pharmacology and Therapeutics. 20: 278-289. PMID 954350 DOI: 10.1002/Cpt1976203278 |
0.408 |
|
1975 |
Till AE, Benet LZ, Kwan KC. An integrated approach to the pharmacokinetic analysis of drug absorption. Journal of Pharmacokinetics and Biopharmaceutics. 2: 525-44. PMID 4461782 DOI: 10.1007/Bf01070946 |
0.374 |
|
1975 |
Gustafson JH, Benet LZ. Biliary excretion kinetics of phenolphthalein glucuronide after intravenous and retrograde biliary administration. The Journal of Pharmacy and Pharmacology. 26: 937-44. PMID 4156858 DOI: 10.1111/J.2042-7158.1974.Tb09212.X |
0.339 |
|
1975 |
Orr JM, Benet LZ. The effect of fasting on the rate of intestinal drug absorption in rats: preliminary studies. The American Journal of Digestive Diseases. 20: 858-65. PMID 1163521 DOI: 10.1007/Bf01070955 |
0.353 |
|
1975 |
Till AE, Benet LZ, Kwan KC. Erratum to: An integrated approach to the pharmacokinetic analysis of drug absorption Journal of Pharmacokinetics and Biopharmaceutics. 3: 291-291. DOI: 10.1007/Bf01066924 |
0.374 |
|
1974 |
Rowland M, Benet LZ, Graham GG. Clearance concepts in pharmacokinetics. Journal of Pharmacokinetics and Biopharmaceutics. 1: 123-36. PMID 4764426 DOI: 10.1007/Bf01059626 |
0.376 |
|
1974 |
Nayak RK, Benet LZ. Use of the unanesthetized rhesus monkey as a model for studying the gastrointestinal absorption of drugs Journal of Pharmacokinetics and Biopharmaceutics. 2: 417-431. PMID 4452944 DOI: 10.1007/Bf01071311 |
0.394 |
|
1973 |
Wolfe DL, Forland SC, Benet LZ. Drug transfer across intact rat intestinal mucosa following surgical removal of serosa and muscularis externa Journal of Pharmaceutical Sciences. 62: 200-205. PMID 4686389 DOI: 10.1002/Jps.2600620203 |
0.304 |
|
1972 |
Benet LZ. General treatment of linear mammillary models with elimination from any compartment as used in pharmacokinetics. Journal of Pharmaceutical Sciences. 61: 536-41. PMID 5014309 DOI: 10.1002/Jps.2600610408 |
0.344 |
|
1972 |
Benet LZ. Chapter 24. Biopharmaceutics and Pharmacokinetics Annual Reports in Medicinal Chemistry. 7: 259-268. DOI: 10.1016/S0065-7743(08)60819-2 |
0.461 |
|
1971 |
Benet LZ, Orr JM, Turner RH, Webb HS. Effect of buffer constituents and time on drug transfer across in vitro rat intestine. Journal of Pharmaceutical Sciences. 60: 234-8. PMID 5572446 DOI: 10.1002/Jps.2600600216 |
0.327 |
|
1971 |
Nayak RK, Benet LZ. Drug transfer across rat intestinal musculature after edetic acid treatment Journal of Pharmaceutical Sciences. 60: 1508-1511. PMID 5001965 DOI: 10.1002/Jps.2600601014 |
0.3 |
|
1971 |
Benet LZ. Chapter 26. Biopharmaceutics and Pharmacokinetics Annual Reports in Medicinal Chemistry. 6: 264-273. DOI: 10.1016/S0065-7743(08)60981-1 |
0.426 |
|
1970 |
Turner RH, Mehta CS, Benet LZ. Apparent directional permeability coefficients for drug ions: in vitro intestinal perfusion studies Journal of Pharmaceutical Sciences. 59: 590-595. PMID 5446410 DOI: 10.1002/Jps.2600590503 |
0.409 |
|
1970 |
Rowland M, Benet LZ, Riegelman S. Two-compartment model for a drug and its metabolite: application to acetylsalicylic acid pharmacokinetics. Journal of Pharmaceutical Sciences. 59: 364-7. PMID 5416180 DOI: 10.1002/Jps.2600590319 |
0.358 |
|
1966 |
Singh P, Guillory JK, Sokoloski TD, Benet LZ, Bhatia VN. Effect of inert tablet ingredients on drug absorption. I. Effect of polyethylene glycol 4000 on the intestinal absorption of four barbiturates. Journal of Pharmaceutical Sciences. 55: 63-8. PMID 5918653 DOI: 10.1002/Jps.2600550114 |
0.321 |
|
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