Kathleen M. Giacomini - Publications

Affiliations: 
Biochemistry and Molecular Biology University of California, San Francisco, San Francisco, CA 
Area:
Molecular Biology, Biochemistry, Pharmacology

259 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Yee SW, Buitrago D, Stecula A, Ngo HX, Chien HC, Zou L, Koleske ML, Giacomini KM. Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 33124720 DOI: 10.1096/fj.202001497R  0.48
2020 Zou L, Matsson P, Stecula A, Ngo HX, Zur AA, Giacomini KM. Drug Metabolites Potently Inhibit Renal Organic Anion Transporters, OAT1 and OAT3. Journal of Pharmaceutical Sciences. PMID 32910949 DOI: 10.1016/j.xphs.2020.09.004  0.52
2020 Wilson JL, Cheung KWK, Lin L, Green EAE, Porrás AI, Zou L, Mukanga D, Akpa PA, Darko DM, Yuan R, Ding S, Johnson WCN, Lee HA, Cooke E, Peck CC, ... ... Giacomini KM, et al. Scientific considerations for global drug development. Science Translational Medicine. 12. PMID 32727913 DOI: 10.1126/scitranslmed.aax2550  0.56
2020 Pottel J, Armstrong D, Zou L, Fekete A, Huang XP, Torosyan H, Bednarczyk D, Whitebread S, Bhhatarai B, Liang G, Jin H, Ghaemi SN, Slocum S, Lukacs KV, Irwin JJ, ... ... Giacomini KM, et al. The activities of drug inactive ingredients on biological targets. Science (New York, N.Y.). 369: 403-413. PMID 32703874 DOI: 10.1126/science.aaz9906  0.48
2020 Lin L, Lemieux GA, Enogieru OJ, Giacomini KM, Ashrafi K. Neural production of kynurenic acid in requires the AAT-1 transporter. Genes & Development. PMID 32675325 DOI: 10.1101/gad.339119.120  0.56
2020 Zou L, Spanogiannopoulos P, Pieper LM, Chien HC, Cai W, Khuri N, Pottel J, Vora B, Ni Z, Tsakalozou E, Zhang W, Shoichet BK, Giacomini KM, Turnbaugh PJ. Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proceedings of the National Academy of Sciences of the United States of America. PMID 32571913 DOI: 10.1073/pnas.1920483117  0.52
2020 Chang YC, Wu JT, Hong MY, Tung YA, Hsieh PH, Yee SW, Giacomini KM, Oyang YJ, Chen CY. GenEpi: gene-based epistasis discovery using machine learning. Bmc Bioinformatics. 21: 68. PMID 32093643 DOI: 10.1186/s12859-020-3368-2  0.48
2020 Zou L, Pottel J, Khuri N, Ngo HX, Ni Z, Tsakalozou E, Warren MS, Huang Y, Shoichet BK, Giacomini KM. Interactions of Oral Molecular Excipients with Breast Cancer Resistance Protein, BCRP. Molecular Pharmaceutics. PMID 31990564 DOI: 10.1021/acs.molpharmaceut.9b00658  0.52
2019 Vora B, Green EAE, Khuri N, Ballgren F, Sirota M, Giacomini KM. Drug-nutrient interactions: discovering prescription drug inhibitors of the thiamine transporter ThTR-2 (SLC19A3). The American Journal of Clinical Nutrition. PMID 31764942 DOI: 10.1093/ajcn/nqz255  0.52
2019 Yee SW, Stecula A, Chien HC, Zou L, Feofanova EV, van Borselen M, Cheung KWK, Yousri NA, Suhre K, Kinchen JM, Boerwinkle E, Irannejad R, Yu B, Giacomini KM. Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies. Plos Genetics. 15: e1008208. PMID 31553721 DOI: 10.1371/journal.pgen.1008208  0.48
2019 Lang S, Hilsabeck TA, Wilson KA, Sharma A, Bose N, Brackman DJ, Beck JN, Chen L, Watson MA, Killilea DW, Ho S, Kahn A, Giacomini K, Stoller ML, Chi T, et al. A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster. Plos Genetics. 15: e1008318. PMID 31415568 DOI: 10.1371/journal.pgen.1008318  0.4
2019 Hall C, Wolfe H, Wells A, Chien HC, Colas C, Schlessinger A, Giacomini KM, Thomas AA. l-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of l-histidine and l-tryptophan. Bioorganic & Medicinal Chemistry Letters. PMID 31248771 DOI: 10.1016/j.bmcl.2019.06.033  0.48
2019 Wun Kathy Cheung K, van Groen BD, Spaans E, van Borselen MD, C J M de Bruijn A, Simons-Oosterhuis Y, Tibboel D, Samsom JN, Verdijk RM, Smeets B, Zhang L, Huang SM, Giacomini KM, de Wildt SN. A comprehensive analysis of ontogeny of renal drug transporters: mRNA analyses, quantitative proteomics and localization. Clinical Pharmacology and Therapeutics. PMID 31127606 DOI: 10.1002/cpt.1516  0.56
2019 Yee SW, Giacomini MM, Shen H, Humphreys WG, Horng H, Brian W, Lai Y, Kroetz DL, Giacomini KM. Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug-Drug Interaction and Associated Biomarker Levels in Healthy Volunteers. Clinical and Translational Science. PMID 30982223 DOI: 10.1111/cts.12625  0.48
2019 Enogieru OJ, Ung PMU, Yee SW, Schlessinger A, Giacomini KM. Functional and Structural Analysis of Rare SLC2A2 Variants Associated with Fanconi-Bickel Syndrome and Metabolic Traits. Human Mutation. PMID 30950137 DOI: 10.1002/humu.23758  0.56
2019 Brackman DJ, Yee SW, Enogieru OJ, Shaffer C, Ranatunga D, Denny JC, Wei WQ, Kamatani Y, Kubo M, Roden DM, Jorgenson E, Giacomini KM. Genome-wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol. Clinical Pharmacology and Therapeutics. PMID 30924126 DOI: 10.1002/cpt.1439  0.56
2019 Giacomini KM, Lin L, Altman RB. Research Projects Supported by the University of California, San Francisco-Stanford Center of Excellence in Regulatory Science and Innovation. Clinical Pharmacology and Therapeutics. PMID 30773618 DOI: 10.1002/cpt.1308  0.56
2019 Zou L, Ni Z, Tsakalozou E, Giacomini KM. Impact of Pharmaceutical Excipients on Oral Drug Absorption: A Focus on Intestinal Drug Transporters. Clinical Pharmacology and Therapeutics. PMID 30663035 DOI: 10.1002/cpt.1292  0.36
2019 Song W, Luo Q, Zhang Y, Zhou L, Liu Y, Ma Z, Guo J, Huang Y, Cheng L, Meng Z, Li Z, Zhang B, Li S, Yee SW, Fan H, ... ... Giacomini KM, et al. Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue. Plos Biology. 17: e2006571. PMID 30653498 DOI: 10.1371/journal.pbio.2006571  0.52
2018 Chu X, Liao M, Shen H, Yoshida K, Zur AA, Arya V, Galetin A, Giacomini KM, Hanna I, Kusuhara H, Lai Y, Rodrigues D, Sugiyama Y, Zamek-Gliszczynski MJ, Zhang L, et al. Clinical Probes and Endogenous Biomarkers as Substrates for Transporter Drug-Drug Interaction Evaluation: Perspectives From the International Transporter Consortium. Clinical Pharmacology and Therapeutics. 104: 836-864. PMID 30347454 DOI: 10.1002/cpt.1216  0.56
2018 Giacomini KM, Galetin A, Huang SM. The International Transporter Consortium: Summarizing advances in the role of transporters in drug development. Clinical Pharmacology and Therapeutics. PMID 30137696 DOI: 10.1002/cpt.1224  0.48
2018 Zamek-Gliszczynski MJ, Taub ME, Chothe PP, Chu X, Giacomini KM, Kim RB, Ray AS, Stocker SL, Unadkat JD, Wittwer MB, Xia C, Yee SW, Zhang L, Zhang Y. Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance. Clinical Pharmacology and Therapeutics. PMID 30091177 DOI: 10.1002/cpt.1112  0.72
2018 Chien HC, Colas C, Finke K, Springer S, Stoner L, Zur AA, Venteicher B, Campbell J, Hall C, Flint A, Augustyn E, Hernandez C, Heeren N, Hansen L, Anthony A, ... ... Giacomini KM, et al. Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1). Journal of Medicinal Chemistry. PMID 30048132 DOI: 10.1021/acs.jmedchem.8b01007  0.52
2018 Srinivasan S, Yee SW, Giacomini KM. Pharmacogenetics of Antidiabetic Drugs. Advances in Pharmacology (San Diego, Calif.). 83: 361-389. PMID 29801583 DOI: 10.1016/bs.apha.2018.04.005  0.48
2018 Zamek-Gliszczynski MJ, Chu X, Cook JA, Custodio JM, Galetin A, Giacomini KM, Lee CA, Paine MF, Ray AS, Ware JA, Wittwer MB, Zhang L. ITC Commentary on Metformin Clinical Drug-Drug Interaction Study Design That Enables an Efficacy- and Safety-Based Dose Adjustment Decision. Clinical Pharmacology and Therapeutics. PMID 29761830 DOI: 10.1002/cpt.1082  0.72
2018 Zou L, Stecula A, Gupta A, Prasad B, Chien HC, Yee SW, Wang L, Unadkat JD, Stahl SH, Fenner KS, Giacomini KM. Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity. Molecular Pharmacology. PMID 29720497 DOI: 10.1124/mol.117.111153  0.48
2018 Yee SW, Brackman DJ, Ennis EA, Sugiyama Y, Kamdem LK, Blanchard R, Galetin A, Zhang L, Giacomini KM. Influence of Transporter Polymorphisms on Drug Disposition and Response: A Perspective from the International Transporter Consortium. Clinical Pharmacology and Therapeutics. PMID 29679469 DOI: 10.1002/cpt.1098  0.56
2018 Liang X, Yee SW, Chien HC, Chen EC, Luo Q, Zou L, Piao M, Mifune A, Chen L, Calvert ME, King S, Norheim F, Abad J, Krauss RM, Giacomini KM. Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content. Plos Biology. 16: e2002907. PMID 29659562 DOI: 10.1371/journal.pbio.2002907  0.48
2018 Rotroff DM, Yee SW, Zhou K, Marvel SW, Shah HS, Jack JR, Havener TM, Hedderson MM, Kubo M, Herman MA, Gao H, Mychaleckyi JC, McLeod HL, Doria A, Giacomini KM, et al. Genetic Variants in and are Associated with Variation in Response to Metformin in Individuals with Type 2 Diabetes. Diabetes. PMID 29650774 DOI: 10.2337/db17-1164  0.48
2017 Zamek-Gliszczynski MJ, Giacomini KM, Zhang L. Emerging Clinical Importance of Hepatic Organic Cation Transporter 1 (OCT1) in Drug Pharmacokinetics, Dynamics, Pharmacogenetic Variability, and Drug Interactions. Clinical Pharmacology and Therapeutics. PMID 29193038 DOI: 10.1002/cpt.941  0.56
2017 Fohner AE, Brackman DJ, Giacomini KM, Altman RB, Klein TE. PharmGKB summary: very important pharmacogene information for ABCG2. Pharmacogenetics and Genomics. PMID 28858993 DOI: 10.1097/FPC.0000000000000305  0.52
2017 Stecula A, Schlessinger A, Giacomini KM, Sali A. Human Concentrative Nucleoside Transporter 3 (hCNT3, SLC28A3) Forms a Cyclic Homotrimer. Biochemistry. PMID 28661652 DOI: 10.1021/acs.biochem.7b00339  0.52
2017 Khuri N, Zur AA, Wittwer MB, Lin L, Yee SW, Sali A, Giacomini KM. Computational Discovery And Experimental Validation of Inhibitors of the Human Intestinal Transporter, OATP2B1. Journal of Chemical Information and Modeling. PMID 28562037 DOI: 10.1021/acs.jcim.6b00720  0.72
2017 Liang X, Giacomini KM. Transporters Involved in Metformin Pharmacokinetics and Treatment Response. Journal of Pharmaceutical Sciences. PMID 28495567 DOI: 10.1016/j.xphs.2017.04.078  0.4
2017 Kathy Cheung KW, Hsueh CH, Zhao P, Meyer TW, Zhang L, Huang SM, Giacomini KM. The Effect of Uremic Solutes on the Organic Cation Transporter 2, OCT2. Journal of Pharmaceutical Sciences. PMID 28483424 DOI: 10.1016/j.xphs.2017.04.076  0.56
2017 Chen EC, Khuri N, Liang X, Stecula A, Chien HC, Yee SW, Huang Y, Sali A, Giacomini KM. Discovery of Competitive and Non-competitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1). Journal of Medicinal Chemistry. PMID 28230985 DOI: 10.1021/acs.jmedchem.6b01317  0.52
2016 Luizon MR, Eckalbar WL, Wang Y, Jones SL, Smith RP, Laurance M, Lin L, Gallins PJ, Etheridge AS, Wright F, Zhou Y, Molony C, Innocenti F, Yee SW, Giacomini KM, et al. Genomic Characterization of Metformin Hepatic Response. Plos Genetics. 12: e1006449. PMID 27902686 DOI: 10.1371/journal.pgen.1006449  0.56
2016 Giacomini KM, Yee SW, Mushiroda T, Weinshilboum RM, Ratain MJ, Kubo M. Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine. Nature Reviews. Drug Discovery. PMID 27885282 DOI: 10.1038/nrd.2016.234  0.48
2016 Dujic T, Zhou K, Yee SW, van Leeuwen N, de Keyser CE, Javorský M, Goswami S, Zaharenko L, Marie M, Christensen H, Out M, Tavendale R, Kubo M, Hedderson MM, van der Heijden AA, ... ... Giacomini KM, et al. Variants in Pharmacokinetic Transporters and Glycaemic Response to Metformin: A MetGen Meta-Analysis. Clinical Pharmacology and Therapeutics. PMID 27859023 DOI: 10.1002/cpt.567  0.48
2016 Zur AA, Chien HC, Augustyn E, Flint A, Heeren N, Finke K, Hernandez C, Hansen L, Miller S, Lin L, Giacomini KM, Colas C, Schlessinger A, Thomas AA. LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates. Bioorganic & Medicinal Chemistry Letters. PMID 27624080 DOI: 10.1016/j.bmcl.2016.09.001  0.32
2016 Irwin JJ, Pottel J, Zou L, Wen H, Zuk S, Zhang X, Sterling T, Shoichet BK, Lionberger R, Giacomini KM. A Molecular Basis for Innovation in Drug Excipients. Clinical Pharmacology and Therapeutics. PMID 27557422 DOI: 10.1002/cpt.458  0.52
2016 Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, ... ... Giacomini KM, et al. Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin. Nature Genetics. PMID 27500523 DOI: 10.1038/ng.3632  0.88
2016 Hsueh CH, Yoshida K, Zhao P, Meyer TW, Zhang L, Huang SM, Giacomini KM. Identification and Quantitative Assessment of Uremic Solutes as Inhibitors of Renal Organic Anion Transporters, OAT1 and OAT3. Molecular Pharmaceutics. PMID 27467266 DOI: 10.1021/acs.molpharmaceut.6b00332  0.88
2016 Yee SW, Giacomini MM, Hsueh CH, Weitz D, Liang X, Goswami S, Kinchen JM, Coelho A, Zur AA, Mertsch K, Brian W, Kroetz DL, Giacomini KM. Metabolomic and Genome-wide Association Studies Reveal Potential Endogenous Biomarkers for OATP1B1. Clinical Pharmacology and Therapeutics. PMID 27447836 DOI: 10.1002/cpt.434  0.88
2016 Goswami S, Yee SW, Xu F, Sridhar SB, Mosley JJ, Takahashi A, Kubo M, Maeda S, Davis RL, Roden DM, Hedderson MM, Giacomini KM, Savic RM. A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin. Clinical Pharmacology and Therapeutics. PMID 27415606 DOI: 10.1002/cpt.428  0.88
2016 Rotroff DM, Oki NO, Liang X, Yee SW, Stocker SL, Corum DG, Meisner M, Fiehn O, Motsinger-Reif AA, Giacomini KM, Kaddurah-Daouk R. Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans. Frontiers in Pharmacology. 7: 135. PMID 27378919 DOI: 10.3389/fphar.2016.00135  0.72
2016 Yee SW, Momozawa Y, Kamatani Y, Tyndale RF, Weinshilboum RM, Ratain MJ, Giacomini KM, Kubo M. Genomewide Association Studies in Pharmacogenomics: Meeting Report of the NIH Pharmacogenomics Research Network-RIKEN (PGRN-RIKEN) Collaboration. Clinical Pharmacology and Therapeutics. PMID 27256705 DOI: 10.1002/cpt.405  0.48
2016 Augustyn E, Finke K, Zur AA, Hansen L, Heeren N, Chien HC, Lin L, Giacomini KM, Colas C, Schlessinger A, Thomas AA. LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs. Bioorganic & Medicinal Chemistry Letters. PMID 27106710 DOI: 10.1016/j.bmcl.2016.04.023  0.32
2016 Altman RB, Prabhu S, Sidow A, Zook JM, Goldfeder R, Litwack D, Ashley E, Asimenos G, Bustamante CD, Donigan K, Giacomini KM, Johansen E, Khuri N, Lee E, Liang XS, et al. A research roadmap for next-generation sequencing informatics. Science Translational Medicine. 8: 335ps10. PMID 27099173 DOI: 10.1126/scitranslmed.aaf7314  0.32
2016 Chhibber A, French CE, Yee SW, Gamazon ER, Theusch E, Qin X, Webb A, Papp AC, Wang A, Simmons CQ, Konkashbaev A, Chaudhry AS, Mitchel K, Stryke D, Ferrin TE, ... ... Giacomini KM, et al. Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines. The Pharmacogenomics Journal. PMID 26856248 DOI: 10.1038/tpj.2015.93  0.48
2015 Chien HC, Zur AA, Maurer TS, Yee SW, Tolsma J, Jasper P, Scott DO, Giacomini KM. Rapid Method to Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in OCT1-transfected HEK Cells. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26700958 DOI: 10.1124/dmd.115.066647  0.88
2015 Altman RB, Khuri N, Salit M, Giacomini KM. Unmet needs: Research helps regulators do their jobs. Science Translational Medicine. 7: 315ps22. PMID 26606966 DOI: 10.1126/scitranslmed.aac4369  0.88
2015 Hibma JE, Zur AA, Castro RA, Wittwer MB, Keizer RJ, Yee SW, Goswami S, Stocker SL, Zhang X, Huang Y, Brett CM, Savic RM, Giacomini KM. The Effect of Famotidine, a MATE1-Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin. Clinical Pharmacokinetics. PMID 26597253 DOI: 10.1007/s40262-015-0346-3  0.88
2015 Liang X, Chien HC, Yee SW, Giacomini MM, Chen EC, Piao M, Hao J, Twelves J, Lepist EI, Ray AS, Giacomini KM. Metformin is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3). Molecular Pharmaceutics. PMID 26528626 DOI: 10.1021/acs.molpharmaceut.5b00501  0.88
2015 Morrissey KM, Stocker SL, Chen EC, Castro RA, Brett CM, Giacomini KM. The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers. Clinical Pharmacokinetics. PMID 26507723 DOI: 10.1007/s40262-015-0332-9  0.88
2015 Yee SW, Lin L, Merski M, Keiser MJ, Gupta A, Zhang Y, Chien HC, Shoichet BK, Giacomini KM. Prediction and validation of enzyme and transporter off-targets for metformin. Journal of Pharmacokinetics and Pharmacodynamics. PMID 26335661 DOI: 10.1007/s10928-015-9436-y  0.88
2015 Lin L, Yee SW, Kim RB, Giacomini KM. SLC transporters as therapeutic targets: emerging opportunities. Nature Reviews. Drug Discovery. 14: 543-60. PMID 26111766 DOI: 10.1038/nrd4626  0.56
2015 Chen EC, Liang X, Yee SW, Geier EG, Stocker SL, Chen L, Giacomini KM. Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin. Molecular Pharmacology. 88: 75-83. PMID 25920679 DOI: 10.1124/mol.114.096776  0.88
2015 Wen CC, Yee SW, Liang X, Hoffmann TJ, Kvale MN, Banda Y, Jorgenson E, Schaefer C, Risch N, Giacomini KM. Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response. Clinical Pharmacology and Therapeutics. 97: 518-25. PMID 25676789 DOI: 10.1002/cpt.89  0.48
2015 Chen L, Yee SW, Giacomini KM. OCT1 in hepatic steatosis and thiamine disposition. Cell Cycle (Georgetown, Tex.). 14: 283-4. PMID 25590948 DOI: 10.1080/15384101.2015.1006532  0.48
2015 Dahlin A, Wittwer M, de la Cruz M, Woo JM, Bam R, Scharen-Guivel V, Flaherty J, Ray AS, Cihlar T, Gupta SK, Giacomini KM. A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome. Pharmacogenetics and Genomics. 25: 82-92. PMID 25485598 DOI: 10.1097/FPC.0000000000000110  0.88
2015 Chen L, Yee SW, Giacomini KM. OCT1 in hepatic steatosis and thiamine disposition Cell Cycle. 14: 283-284. DOI: 10.1080/15384101.2015.1006532  0.88
2015 Lin L, Yee SW, Kim RB, Giacomini KM. SLC transporters as therapeutic targets: Emerging opportunities Nature Reviews Drug Discovery. 14: 543-560. DOI: 10.1038/nrd4626  0.88
2014 Smith RP, Eckalbar WL, Morrissey KM, Luizon MR, Hoffmann TJ, Sun X, Jones SL, Force Aldred S, Ramamoorthy A, Desta Z, Liu Y, Skaar TC, Trinklein ND, Giacomini KM, Ahituv N. Genome-wide discovery of drug-dependent human liver regulatory elements. Plos Genetics. 10: e1004648. PMID 25275310 DOI: 10.1371/journal.pgen.1004648  0.88
2014 Pawlyk AC, Giacomini KM, McKeon C, Shuldiner AR, Florez JC. Metformin pharmacogenomics: current status and future directions. Diabetes. 63: 2590-9. PMID 25060887 DOI: 10.2337/db13-1367  0.88
2014 Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, ... ... Giacomini KM, et al. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proceedings of the National Academy of Sciences of the United States of America. 111: 9983-8. PMID 24961373 DOI: 10.1073/pnas.1314939111  0.72
2014 Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, ... ... Giacomini KM, et al. Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin. Clinical Pharmacology and Therapeutics. 96: 370-9. PMID 24853734 DOI: 10.1038/clpt.2014.109  0.88
2014 Goswami S, Gong L, Giacomini K, Altman RB, Klein TE. PharmGKB summary: very important pharmacogene information for SLC22A1. Pharmacogenetics and Genomics. 24: 324-8. PMID 24681965 DOI: 10.1097/FPC.0000000000000048  0.88
2014 Clancy JP, Johnson SG, Yee SW, McDonagh EM, Caudle KE, Klein TE, Cannavo M, Giacomini KM. Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for ivacaftor therapy in the context of CFTR genotype. Clinical Pharmacology and Therapeutics. 95: 592-7. PMID 24598717 DOI: 10.1038/clpt.2014.54  0.88
2014 Hsu V, de L T Vieira M, Zhao P, Zhang L, Zheng JH, Nordmark A, Berglund EG, Giacomini KM, Huang SM. Towards quantitation of the effects of renal impairment and probenecid inhibition on kidney uptake and efflux transporters, using physiologically based pharmacokinetic modelling and simulations. Clinical Pharmacokinetics. 53: 283-93. PMID 24214317 DOI: 10.1007/s40262-013-0117-y  0.88
2014 Drake KA, Torgerson DG, Gignoux CR, Galanter JM, Roth LA, Huntsman S, Eng C, Oh SS, Yee SW, Lin L, Bustamante CD, Moreno-Estrada A, Sandoval K, Davis A, Borrell LN, ... ... Giacomini KM, et al. A genome-wide association study of bronchodilator response in Latinos implicates rare variants. The Journal of Allergy and Clinical Immunology. 133: 370-8. PMID 23992748 DOI: 10.1016/j.jaci.2013.06.043  0.88
2013 Geier EG, Chen EC, Webb A, Papp AC, Yee SW, Sadee W, Giacomini KM. Profiling solute carrier transporters in the human blood-brain barrier. Clinical Pharmacology and Therapeutics. 94: 636-9. PMID 24013810 DOI: 10.1038/clpt.2013.175  0.88
2013 Mushiroda T, Giacomini KM, Kubo M. Special Section on Pharmacogenomics: recent advances and future directions. Journal of Human Genetics. 58: 305. PMID 23797326 DOI: 10.1038/jhg.2013.53  0.88
2013 Giacomini KM, Balimane PV, Cho SK, Eadon M, Edeki T, Hillgren KM, Huang SM, Sugiyama Y, Weitz D, Wen Y, Xia CQ, Yee SW, Zimdahl H, Niemi M. International Transporter Consortium commentary on clinically important transporter polymorphisms. Clinical Pharmacology and Therapeutics. 94: 23-6. PMID 23778707 DOI: 10.1038/clpt.2013.12  0.88
2013 Schlessinger A, Yee SW, Sali A, Giacomini KM. SLC classification: An update Clinical Pharmacology and Therapeutics. 94: 19-23. PMID 23778706 DOI: 10.1038/clpt.2013.73  0.88
2013 Giacomini KM, Huang SM. Transporters in drug development and clinical pharmacology Clinical Pharmacology and Therapeutics. 94: 3-9. PMID 23778703 DOI: 10.1038/clpt.2013.86  0.88
2013 Yee SW, Mefford JA, Singh N, Percival ME, Stecula A, Yang K, Witte JS, Takahashi A, Kubo M, Matsuda K, Giacomini KM, Andreadis C. Impact of polymorphisms in drug pathway genes on disease-free survival in adults with acute myeloid leukemia. Journal of Human Genetics. 58: 353-61. PMID 23677058 DOI: 10.1038/jhg.2013.38  0.88
2013 Yee SW, Nguyen AN, Brown C, Savic RM, Zhang Y, Castro RA, Cropp CD, Choi JH, Singh D, Tahara H, Stocker SL, Huang Y, Brett CM, Giacomini KM. Reduced renal clearance of cefotaxime in asians with a low-frequency polymorphism of OAT3 (SLC22A8). Journal of Pharmaceutical Sciences. 102: 3451-7. PMID 23649425 DOI: 10.1002/jps.23581  0.88
2013 Hillgren KM, Keppler D, Zur AA, Giacomini KM, Stieger B, Cass CE, Zhang L. Emerging transporters of clinical importance: An update from the international transporter consortium Clinical Pharmacology and Therapeutics. 94: 52-63. PMID 23588305 DOI: 10.1038/clpt.2013.74  0.88
2013 Schlessinger A, Khuri N, Giacomini KM, Sali A. Molecular modeling and ligand docking for solute carrier (SLC) transporters. Current Topics in Medicinal Chemistry. 13: 843-56. PMID 23578028  0.88
2013 Geier EG, Schlessinger A, Fan H, Gable JE, Irwin JJ, Sali A, Giacomini KM. Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1. Proceedings of the National Academy of Sciences of the United States of America. 110: 5480-5. PMID 23509259 DOI: 10.1073/pnas.1218165110  0.88
2013 Dahlin A, Geier E, Stocker SL, Cropp CD, Grigorenko E, Bloomer M, Siegenthaler J, Xu L, Basile AS, Tang-Liu DD, Giacomini KM. Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures. Molecular Pharmaceutics. 10: 650-63. PMID 23268600 DOI: 10.1021/mp300429e  0.88
2013 Stocker SL, Morrissey KM, Yee SW, Castro RA, Xu L, Dahlin A, Ramirez AH, Roden DM, Wilke RA, McCarty CA, Davis RL, Brett CM, Giacomini KM. The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin. Clinical Pharmacology and Therapeutics. 93: 186-94. PMID 23267855 DOI: 10.1038/clpt.2012.210  0.88
2013 Wittwer MB, Zur AA, Khuri N, Kido Y, Kosaka A, Zhang X, Morrissey KM, Sali A, Huang Y, Giacomini KM. Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. Journal of Medicinal Chemistry. 56: 781-95. PMID 23241029 DOI: 10.1021/jm301302s  0.88
2013 Morrissey KM, Stocker SL, Wittwer MB, Xu L, Giacomini KM. Renal transporters in drug development. Annual Review of Pharmacology and Toxicology. 53: 503-29. PMID 23140242 DOI: 10.1146/annurev-pharmtox-011112-140317  0.88
2013 Chen L, Hong C, Chen EC, Yee SW, Xu L, Almof EU, Wen C, Fujii K, Johns SJ, Stryke D, Ferrin TE, Simko J, Chen X, Costello JF, Giacomini KM. Genetic and epigenetic regulation of the organic cation transporter 3, SLC22A3 Pharmacogenomics Journal. 13: 110-120. PMID 22231567 DOI: 10.1038/tpj.2011.60  0.88
2013 Matsson PD, Giacomini KM, Brater CC. Renal Disposition of Drugs and Translation to Dosing Strategies Seldin and Geibisch's the Kidney. 2: 3185-3214. DOI: 10.1016/B978-0-12-381462-3.00095-1  0.88
2013 Stocker SL, Riedmaier AE, Schwab M, Giacomini KM. OCT (SLC22A) and OCTN Family Pharmacogenomics of Human Drug Transporters: Clinical Impacts. 171-208. DOI: 10.1002/9781118353240.ch8  0.88
2013 Yee SW, Kroetz DL, Giacomini KM. The Pharmacogenomics of Membrane Transporters Project Pharmacogenomics of Human Drug Transporters: Clinical Impacts. 73-108. DOI: 10.1002/9781118353240.ch4  0.88
2012 Zamek-Gliszczynski MJ, Hoffmaster KA, Tweedie DJ, Giacomini KM, Hillgren KM. Highlights from the international transporter consortium second workshop Clinical Pharmacology and Therapeutics. 92: 553-556. PMID 23085880 DOI: 10.1038/clpt.2012.126  0.88
2012 Morrissey KM, Wen CC, Johns SJ, Zhang L, Huang SM, Giacomini KM. The UCSF-FDA TransPortal: a public drug transporter database. Clinical Pharmacology and Therapeutics. 92: 545-6. PMID 23085876 DOI: 10.1038/clpt.2012.44  0.88
2012 Dubois SG, Geier E, Batra V, Yee SW, Neuhaus J, Segal M, Martinez D, Pawel B, Yanik G, Naranjo A, London WB, Kreissman S, Baker D, Attiyeh E, Hogarty MD, ... ... Giacomini K, et al. Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children's Oncology Group. International Journal of Molecular Imaging. 2012: 250834. PMID 23050139 DOI: 10.1155/2012/250834  0.48
2012 Giacomini KM, Yee SW, Ratain MJ, Weinshilboum RM, Kamatani N, Nakamura Y. Pharmacogenomics and patient care: one size does not fit all. Science Translational Medicine. 4: 153ps18. PMID 23019654 DOI: 10.1126/scitranslmed.3003471  0.88
2012 Schlessinger A, Wittwer MB, Dahlin A, Khuri N, Bonomi M, Fan H, Giacomini KM, Sali A. High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach. The Journal of Biological Chemistry. 287: 37745-56. PMID 22932902 DOI: 10.1074/jbc.M112.388157  0.88
2012 Smith DE, Rowland M, Giacomini KM, Amidon GL. Dedication to professor Leslie Z. Benet: 50 years of scientific excellence and still going strong! Pharmaceutical Research. 29: 2345-53. PMID 22814901 DOI: 10.1007/s11095-012-0808-3  0.88
2012 Gong L, Goswami S, Giacomini KM, Altman RB, Klein TE. Metformin pathways: pharmacokinetics and pharmacodynamics. Pharmacogenetics and Genomics. 22: 820-7. PMID 22722338 DOI: 10.1097/FPC.0b013e3283559b22  0.88
2012 Yee SW, Chen L, Giacomini KM. The role of ATM in response to metformin treatment and activation of AMPK. Nature Genetics. 44: 359-60. PMID 22456732 DOI: 10.1038/ng.2236  0.88
2012 Ramsey LB, Bruun GH, Yang W, Treviño LR, Vattathil S, Scheet P, Cheng C, Rosner GL, Giacomini KM, Fan Y, Sparreboom A, Mikkelsen TS, Corydon TJ, Pui CH, Evans WE, et al. Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition. Genome Research. 22: 1-8. PMID 22147369 DOI: 10.1101/gr.129668.111  0.88
2012 Innocenti F, Owzar K, Cox NL, Evans P, Kubo M, Zembutsu H, Jiang C, Hollis D, Mushiroda T, Li L, Friedman P, Wang L, Glubb D, Hurwitz H, Giacomini KM, et al. A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 577-84. PMID 22142827 DOI: 10.1158/1078-0432.CCR-11-1387  0.88
2012 Matsson P, Yee SW, Markova S, Morrissey K, Jenkins G, Xuan J, Jorgenson E, Kroetz DL, Giacomini KM. Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping. The Pharmacogenomics Journal. 12: 214-26. PMID 21383772 DOI: 10.1038/tpj.2011.8  0.88
2011 Choi JH, Yee SW, Ramirez AH, Morrissey KM, Jang GH, Joski PJ, Mefford JA, Hesselson SE, Schlessinger A, Jenkins G, Castro RA, Johns SJ, Stryke D, Sali A, Ferrin TE, ... ... Giacomini KM, et al. A common 5'-UTR variant in MATE2-K is associated with poor response to metformin. Clinical Pharmacology and Therapeutics. 90: 674-84. PMID 21956618 DOI: 10.1038/clpt.2011.165  0.88
2011 Schlessinger A, Geier E, Fan H, Irwin JJ, Shoichet BK, Giacomini KM, Sali A. Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET. Proceedings of the National Academy of Sciences of the United States of America. 108: 15810-5. PMID 21885739 DOI: 10.1073/pnas.1106030108  0.88
2011 Kido Y, Matsson P, Giacomini KM. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of Medicinal Chemistry. 54: 4548-58. PMID 21599003 DOI: 10.1021/jm2001629  0.88
2011 Picard N, Levoir L, Lamoureux F, Yee SW, Giacomini KM, Marquet P. Interaction of sirolimus and everolimus with hepatic and intestinal organic anion-transporting polypeptide transporters. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 41: 752-7. PMID 21524191 DOI: 10.3109/00498254.2011.573882  0.88
2011 More SS, Itsara M, Yang X, Geier EG, Tadano MK, Seo Y, Vanbrocklin HF, Weiss WA, Mueller S, Haas-Kogan DA, Dubois SG, Matthay KK, Giacomini KM. Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 2339-49. PMID 21421857 DOI: 10.1158/1078-0432.CCR-10-2949  0.88
2011 Kim MJ, Skewes-Cox P, Fukushima H, Hesselson S, Yee SW, Ramsey LB, Nguyen L, Eshragh JL, Castro RA, Wen CC, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Relling MV, ... Giacomini KM, et al. Functional characterization of liver enhancers that regulate drug-associated transporters. Clinical Pharmacology and Therapeutics. 89: 571-8. PMID 21368754 DOI: 10.1038/clpt.2010.353  0.88
2011 Minematsu T, Giacomini KM. Interactions of tyrosine kinase inhibitors with organic cation transporters and multidrug and toxic compound extrusion proteins. Molecular Cancer Therapeutics. 10: 531-9. PMID 21252289 DOI: 10.1158/1535-7163.MCT-10-0731  0.88
2011 Chen L, Xue L, Giacomini KM, Casida JE. GABAA receptor open-state conformation determines non-competitive antagonist binding. Toxicology and Applied Pharmacology. 250: 221-8. PMID 21111751 DOI: 10.1016/j.taap.2010.11.010  0.88
2011 Li S, Chen Y, Zhang S, More SS, Huang X, Giacomini KM. Role of organic cation transporter 1, OCT1 in the pharmacokinetics and toxicity of cis-diammine(pyridine)chloroplatinum(II) and oxaliplatin in mice. Pharmaceutical Research. 28: 610-25. PMID 21104302 DOI: 10.1007/s11095-010-0312-6  0.88
2011 Miller WL, Agrawal V, Sandee D, Tee MK, Huang N, Choi JH, Morrissey K, Giacomini KM. Consequences of POR mutations and polymorphisms. Molecular and Cellular Endocrinology. 336: 174-9. PMID 21070833 DOI: 10.1016/j.mce.2010.10.022  0.88
2011 Ahlin G, Chen L, Lazorova L, Chen Y, Ianculescu AG, Davis RL, Giacomini KM, Artursson P. Genotype-dependent effects of inhibitors of the organic cation transporter, OCT1: predictions of metformin interactions. The Pharmacogenomics Journal. 11: 400-11. PMID 20567254 DOI: 10.1038/tpj.2010.54  0.88
2010 Sandee D, Morrissey K, Agrawal V, Tam HK, Kramer MA, Tracy TS, Giacomini KM, Miller WL. Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro. Pharmacogenetics and Genomics. 20: 677-86. PMID 20940534 DOI: 10.1097/FPC.0b013e32833f4f9b  0.88
2010 Chen L, Pawlikowski B, Schlessinger A, More SS, Stryke D, Johns SJ, Portman MA, Chen E, Ferrin TE, Sali A, Giacomini KM. Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin. Pharmacogenetics and Genomics. 20: 687-99. PMID 20859243 DOI: 10.1097/FPC.0b013e32833fe789  0.88
2010 Yee SW, Gong L, Badagnani I, Giacomini KM, Klein TE, Altman RB. SLC19A1 pharmacogenomics summary. Pharmacogenetics and Genomics. 20: 708-15. PMID 20811316 DOI: 10.1097/FPC.0b013e32833eca92  0.88
2010 Agrawal V, Choi JH, Giacomini KM, Miller WL. Substrate-specific modulation of CYP3A4 activity by genetic variants of cytochrome P450 oxidoreductase. Pharmacogenetics and Genomics. 20: 611-8. PMID 20697309 DOI: 10.1097/FPC.0b013e32833e0cb5  0.88
2010 Shima JE, Komori T, Taylor TR, Stryke D, Kawamoto M, Johns SJ, Carlson EJ, Ferrin TE, Giacomini KM. Genetic variants of human organic anion transporter 4 demonstrate altered transport of endogenous substrates. American Journal of Physiology. Renal Physiology. 299: F767-75. PMID 20668102 DOI: 10.1152/ajprenal.00312.2010  0.88
2010 Chen L, Takizawa M, Chen E, Schlessinger A, Segenthelar J, Choi JH, Sali A, Kubo M, Nakamura S, Iwamoto Y, Iwasaki N, Giacomini KM. Genetic polymorphisms in organic cation transporter 1 (OCT1) in Chinese and Japanese populations exhibit altered function. The Journal of Pharmacology and Experimental Therapeutics. 335: 42-50. PMID 20639304 DOI: 10.1124/jpet.110.170159  0.88
2010 More SS, Akil O, Ianculescu AG, Geier EG, Lustig LR, Giacomini KM. Role of the copper transporter, CTR1, in platinum-induced ototoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9500-9. PMID 20631178 DOI: 10.1523/JNEUROSCI.1544-10.2010  0.88
2010 More SS, Li S, Yee SW, Chen L, Xu Z, Jablons DM, Giacomini KM. Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue. Molecular Cancer Therapeutics. 9: 1058-69. PMID 20371711 DOI: 10.1158/1535-7163.MCT-09-1084  0.88
2010 Ianculescu AG, Friesema ECH, Visser TJ, Giacomini KM, Scanlan TS. Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine Molecular Biosystems. 6: 1403-1410. PMID 20358049 DOI: 10.1039/b926588k  0.88
2010 Yee SW, Chen L, Giacomini KM. Pharmacogenomics of membrane transporters: past, present and future. Pharmacogenomics. 11: 475-9. PMID 20350125 DOI: 10.2217/pgs.10.22  0.88
2010 Giacomini KM, Huang SM, Tweedie DJ, Benet LZ, Brouwer KL, Chu X, Dahlin A, Evers R, Fischer V, Hillgren KM, Hoffmaster KA, Ishikawa T, Keppler D, Kim RB, et al. Membrane transporters in drug development. Nature Reviews. Drug Discovery. 9: 215-36. PMID 20190787 DOI: 10.1038/nrd3028  0.88
2010 Schlessinger A, Matsson P, Shima JE, Pieper U, Yee SW, Kelly L, Apeltsin L, Stroud RM, Ferrin TE, Giacomini KM, Sali A. Comparison of human solute carriers. Protein Science : a Publication of the Protein Society. 19: 412-28. PMID 20052679 DOI: 10.1002/pro.320  0.88
2010 Huang SM, Zhang L, Giacomini KM. The international transporter consortium: A collaborative group of scientists from academia, industry, and the FDA Clinical Pharmacology and Therapeutics. 87: 32-36. PMID 20019700 DOI: 10.1038/clpt.2009.236  0.88
2010 Kroetz DL, Yee SW, Giacomini KM. The pharmacogenomics of membrane transporters project: research at the interface of genomics and transporter pharmacology. Clinical Pharmacology and Therapeutics. 87: 109-16. PMID 19940846 DOI: 10.1038/clpt.2009.226  0.88
2010 Picard N, Yee SW, Woillard JB, Lebranchu Y, Le Meur Y, Giacomini KM, Marquet P. The role of organic anion-transporting polypeptides and their common genetic variants in mycophenolic acid pharmacokinetics Clinical Pharmacology and Therapeutics. 87: 100-108. PMID 19890249 DOI: 10.1038/clpt.2009.205  0.88
2009 Treviño LR, Shimasaki N, Yang W, Panetta JC, Cheng C, Pei D, Chan D, Sparreboom A, Giacomini KM, Pui CH, Evans WE, Relling MV. Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: 5972-8. PMID 19901119 DOI: 10.1200/JCO.2008.20.4156  0.88
2009 Kroetz DL, Ahituv N, Burchard EG, Guo S, Sali A, Giacomini KM. Institutional Profile: The University of California Pharmacogenomics Center: at the interface of genomics, biological mechanisms and drug therapy. Pharmacogenomics. 10: 1569-76. PMID 19842929 DOI: 10.2217/pgs.09.119  0.88
2009 Kelly L, Pieper U, Eswar N, Hays FA, Li M, Roe-Zurz Z, Kroetz DL, Giacomini KM, Stroud RM, Sali A. A survey of integral alpha-helical membrane proteins. Journal of Structural and Functional Genomics. 10: 269-80. PMID 19760129 DOI: 10.1007/s10969-009-9069-8  0.88
2009 Ha Choi J, Wah Yee S, Kim MJ, Nguyen L, Ho Lee J, Kang JO, Hesselson S, Castro RA, Stryke D, Johns SJ, Kwok PY, Ferrin TE, Goo Lee M, Black BL, Ahituv N, ... Giacomini KM, et al. Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1 Pharmacogenetics and Genomics. 19: 770-780. PMID 19745787 DOI: 10.1097/FPC.0b013e328330eeca  0.88
2009 Hesselson SE, Matsson P, Shima JE, Fukushima H, Yee SW, Kobayashi Y, Gow JM, Ha C, Ma B, Poon A, Johns SJ, Stryke D, Castro RA, Tahara H, Choi JH, ... ... Giacomini KM, et al. Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation. Plos One. 4: e6942. PMID 19742321 DOI: 10.1371/journal.pone.0006942  0.88
2009 McBride BF, Yang T, Liu K, Urban TJ, Giacomini KM, Kim RB, Roden DM. The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel. Journal of Cardiovascular Pharmacology. 54: 63-71. PMID 19528813 DOI: 10.1097/FJC.0b013e3181abc288  0.88
2009 Chen Y, Li S, Brown C, Cheatham S, Castro RA, Leabman MK, Urban TJ, Chen L, Yee SW, Choi JH, Huang Y, Brett CM, Burchard EG, Giacomini KM. Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin. Pharmacogenetics and Genomics. 19: 497-504. PMID 19483665 DOI: 10.1097/FPC.0b013e32832cc7e9  0.88
2009 Chen Y, Teranishi K, Li S, Yee SW, Hesselson S, Stryke D, Johns SJ, Ferrin TE, Kwok P, Giacomini KM. Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function. The Pharmacogenomics Journal. 9: 127-36. PMID 19172157 DOI: 10.1038/tpj.2008.19  0.88
2009 Tahara H, Yee SW, Urban TJ, Hesselson S, Castro RA, Kawamoto M, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Giacomini KM. Functional genetic variation in the basal promoter of the organic cation/carnitine transporters OCTN1 (SLC22A4) and OCTN2 (SLC22A5). The Journal of Pharmacology and Experimental Therapeutics. 329: 262-71. PMID 19141711 DOI: 10.1124/jpet.108.146449  0.88
2009 Yee SW, Shima JE, Hesselson S, Nguyen L, De Val S, Lafond RJ, Kawamoto M, Johns SJ, Stryke D, Kwok PY, Ferrin TE, Black BL, Gurwitz D, Ahituv N, Giacomini KM. Identification and characterization of proximal promoter polymorphisms in the human concentrative nucleoside transporter 2 (SLC28A2). The Journal of Pharmacology and Experimental Therapeutics. 328: 699-707. PMID 19098160 DOI: 10.1124/jpet.108.147207  0.88
2009 Lanculescu AG, Giacomini KM, Scanlan TS. Identification and characterization of 3-iodothyronamine intracellular transport Endocrinology. 150: 1991-1999. PMID 19074582 DOI: 10.1210/en.2008-1339  0.88
2009 Li M, Hays FA, Roe-Zurz Z, Vuong L, Kelly L, Ho CM, Robbins RM, Pieper U, O'Connell JD, Miercke LJ, Giacomini KM, Sali A, Stroud RM. Selecting optimum eukaryotic integral membrane proteins for structure determination by rapid expression and solubilization screening. Journal of Molecular Biology. 385: 820-30. PMID 19061901 DOI: 10.1016/j.jmb.2008.11.021  0.88
2009 Miller WL, Huang N, Agrawal V, Giacomini KM. Genetic variation in human P450 oxidoreductase. Molecular and Cellular Endocrinology. 300: 180-4. PMID 18930113 DOI: 10.1016/j.mce.2008.09.017  0.88
2009 Cropp CD, Yee SW, Giacomini KM. Genetic variation in drug transporters in ethnic populations (Clinical Pharmacology and Therapeutics (2008) 84, (412-416) DOI: 10.1038/clpt.2008.98) Clinical Pharmacology and Therapeutics. 85: 108-109. DOI: 10.1038/clpt.2008.232  0.88
2008 Weiss ST, McLeod HL, Flockhart DA, Dolan ME, Benowitz NL, Johnson JA, Ratain MJ, Giacomini KM. Creating and evaluating genetic tests predictive of drug response. Nature Reviews. Drug Discovery. 7: 568-74. PMID 18587383 DOI: 10.1038/nrd2520  0.88
2008 Lovejoy KS, Todd RC, Zhang S, McCormick MS, D'Aquino JA, Reardon JT, Sancar A, Giacomini KM, Lippard SJ. cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects. Proceedings of the National Academy of Sciences of the United States of America. 105: 8902-7. PMID 18579768 DOI: 10.1073/pnas.0803441105  0.88
2008 Cropp CD, Yee SW, Giacomini KM. Genetic variation in drug transporters in ethnic populations. Clinical Pharmacology and Therapeutics. 84: 412-6. PMID 18528433 DOI: 10.1038/clpt.2008.98  0.88
2008 Sorani MD, Zador Z, Hurowitz E, Yan D, Giacomini KM, Manley GT. Novel variants in human Aquaporin-4 reduce cellular water permeability. Human Molecular Genetics. 17: 2379-89. PMID 18511455 DOI: 10.1093/hmg/ddn138  0.88
2008 Sorani MD, Manley GT, Giacomini KM. Genetic variation in human aquaporins and effects on phenotypes of water homeostasis. Human Mutation. 29: 1108-17. PMID 18470935 DOI: 10.1002/humu.20762  0.88
2008 Sorani MD, Morabito D, Rosenthal G, Giacomini KM, Manley GT. Characterizing the dose-response relationship between mannitol and intracranial pressure in traumatic brain injury patients using a high-frequency physiological data collection system. Journal of Neurotrauma. 25: 291-8. PMID 18373479 DOI: 10.1089/neu.2007.0411  0.88
2008 Abla N, Chinn LW, Nakamura T, Liu L, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Ferrin TE, Giacomini KM, Kroetz DL. The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene. The Journal of Pharmacology and Experimental Therapeutics. 325: 859-68. PMID 18364470 DOI: 10.1124/jpet.108.136523  0.88
2008 Huang N, Agrawal V, Giacomini KM, Miller WL. Genetics of P450 oxidoreductase: sequence variation in 842 individuals of four ethnicities and activities of 15 missense mutations. Proceedings of the National Academy of Sciences of the United States of America. 105: 1733-8. PMID 18230729 DOI: 10.1073/pnas.0711621105  0.88
2008 Cropp CD, Komori T, Shima JE, Urban TJ, Yee SW, More SS, Giacomini KM. Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP. Molecular Pharmacology. 73: 1151-8. PMID 18216183 DOI: 10.1124/mol.107.043117  0.88
2008 Urban TJ, Brown C, Castro RA, Shah N, Mercer R, Huang Y, Brett CM, Burchard EG, Giacomini KM. Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin. Clinical Pharmacology and Therapeutics. 83: 416-21. PMID 17609685 DOI: 10.1038/sj.clpt.6100271  0.88
2008 Shu Y, Brown C, Castro RA, Shi RJ, Lin ET, Owen RP, Sheardown SA, Yue L, Burchard EG, Brett CM, Giacomini KM. Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics. Clinical Pharmacology and Therapeutics. 83: 273-80. PMID 17609683 DOI: 10.1038/sj.clpt.6100275  0.88
2007 Wilke RA, Lin DW, Roden DM, Watkins PB, Flockhart D, Zineh I, Giacomini KM, Krauss RM. Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges. Nature Reviews. Drug Discovery. 6: 904-16. PMID 17971785 DOI: 10.1038/nrd2423  0.88
2007 Urban TJ, Yang C, Lagpacan LL, Brown C, Castro RA, Taylor TR, Huang CC, Stryke D, Johns SJ, Kawamoto M, Carlson EJ, Ferrin TE, Burchard EG, Giacomini KM. Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4). Pharmacogenetics and Genomics. 17: 773-82. PMID 17700366 DOI: 10.1097/FPC.0b013e3281c6d08e.  0.88
2007 Chen Y, Zhang S, Sorani M, Giacomini KM. Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family. The Journal of Pharmacology and Experimental Therapeutics. 322: 695-700. PMID 17495125 DOI: 10.1124/jpet.107.123554  0.88
2007 Shu Y, Sheardown SA, Brown C, Owen RP, Zhang S, Castro RA, Ianculescu AG, Yue L, Lo JC, Burchard EG, Brett CM, Giacomini KM. Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. The Journal of Clinical Investigation. 117: 1422-31. PMID 17476361 DOI: 10.1172/JCI30558  0.88
2007 Altman RB, Benowitz N, Gurwitz D, Lunshof J, Relling M, Lamba J, Wieben E, Mooney S, Giacomini K, Weiss S, Johnson JA, McLeod H, Flockhart D, Weinshilboum R, Shuldiner AR, et al. Genetic nondiscrimination legislation: a critical prerequisite for pharmacogenomics data sharing. Pharmacogenomics. 8: 519. PMID 17465717 DOI: 10.2217/14622416.8.5.519  0.88
2007 Giacomini KM, Krauss RM, Roden DM, Eichelbaum M, Hayden MR, Nakamura Y. When good drugs go bad. Nature. 446: 975-7. PMID 17460642 DOI: 10.1038/446975a  0.88
2007 Giacomini KM, Brett CM, Altman RB, Benowitz NL, Dolan ME, Flockhart DA, Johnson JA, Hayes DF, Klein T, Krauss RM, Kroetz DL, McLeod HL, Nguyen AT, Ratain MJ, Relling MV, et al. The pharmacogenetics research network: from SNP discovery to clinical drug response. Clinical Pharmacology and Therapeutics. 81: 328-45. PMID 17339863 DOI: 10.1038/sj.clpt.6100087  0.88
2006 Roden DM, Altman RB, Benowitz NL, Flockhart DA, Giacomini KM, Johnson JA, Krauss RM, McLeod HL, Ratain MJ, Relling MV, Ring HZ, Shuldiner AR, Weinshilboum RM, Weiss ST. Pharmacogenomics: challenges and opportunities. Annals of Internal Medicine. 145: 749-57. PMID 17116919  0.88
2006 Zhang S, Lovejoy KS, Shima JE, Lagpacan LL, Shu Y, Lapuk A, Chen Y, Komori T, Gray JW, Chen X, Lippard SJ, Giacomini KM. Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Research. 66: 8847-57. PMID 16951202 DOI: 10.1158/0008-5472.CAN-06-0769  0.88
2006 Urban TJ, Gallagher RC, Brown C, Castro RA, Lagpacan LL, Brett CM, Taylor TR, Carlson EJ, Ferrin TE, Burchard EG, Packman S, Giacomini KM. Functional genetic diversity in the high-affinity carnitine transporter OCTN2 (SLC22A5). Molecular Pharmacology. 70: 1602-11. PMID 16931768 DOI: 10.1124/mol.106.028126  0.88
2006 Owen RP, Badagnani I, Giacomini KM. Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2. The Journal of Biological Chemistry. 281: 26675-82. PMID 16840788 DOI: 10.1074/jbc.M513421200  0.88
2006 Badagnani I, Castro RA, Taylor TR, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM. Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants. The Journal of Pharmacology and Experimental Therapeutics. 318: 521-9. PMID 16702441 DOI: 10.1124/jpet.106.104364  0.88
2006 Badagnani I, Sorani M, Edwards RH, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Carlson EJ, Taylor T, Chan W, De La Cruz M, Ferrin TE, Burchard EG, ... ... Giacomini KM, et al. PharmGKB submission update: VI. PMT submissions of genetic variations in neurotransmitter transporters (SLC6, SLC17, and SLC18) to the PharmGKB network. Pharmacological Reviews. 58: 5-6. PMID 16507879 DOI: 10.1124/pr.58.1.3  0.88
2006 Shu Y, Urban TJ, Leabman MK, Fujita T, Erdman AR, Lagpacan LL, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Taylor TR, Chan W, De La Cruz M, ... ... Giacomini KM, et al. PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters. Pharmacological Reviews. 58: 3-4. PMID 16507878 DOI: 10.1124/pr.58.1.2  0.88
2006 Nguyen TD, Gow JM, Chinn LW, Kelly L, Jeong H, Huang CC, Stryke D, Kawamoto M, Johns SJ, Carlson E, Taylor T, Ferrin TE, Sali A, Giacomini KM, Kroetz DL. PharmGKB submission update: IV. PMT submissions of genetic variations in ATP-Binding cassette transporters to the PharmGKB network. Pharmacological Reviews. 58: 1-2. PMID 16507877 DOI: 10.1124/pr.58.1.1  0.88
2006 Urban TJ, Sebro R, Hurowitz EH, Leabman MK, Badagnani I, Lagpacan LL, Risch N, Giacomini KM. Functional genomics of membrane transporters in human populations. Genome Research. 16: 223-30. PMID 16354753 DOI: 10.1101/gr.4356206  0.88
2006 Fujita T, Urban TJ, Leabman MK, Fujita K, Giacomini KM. Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants. Journal of Pharmaceutical Sciences. 95: 25-36. PMID 16307453 DOI: 10.1002/jps.20536  0.88
2006 Erdman AR, Mangravite LM, Urban TJ, Lagpacan LL, Castro RA, de la Cruz M, Chan W, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Carlson EJ, Ferrin TE, Brett CM, ... ... Giacomini KM, et al. The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. American Journal of Physiology. Renal Physiology. 290: F905-12. PMID 16291576 DOI: 10.1152/ajprenal.00272.2005  0.88
2006 Owen RP, Lagpacan LL, Taylor TR, De La Cruz M, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, Giacomini KM. Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 12-5. PMID 16214850 DOI: 10.1124/dmd.105.006270  0.88
2006 Giacomini KM, Chen X. Pharmacogenetics: Focus on the Liver Zakim and Boyer's Hepatology. 53-66. DOI: 10.1016/B978-1-4160-3258-8.50009-7  0.88
2006 Urban TJ, Giacomini KM. Organic Cation Transporters Drug Transporters: Molecular Characterization and Role in Drug Disposition. 11-33. DOI: 10.1002/9780470140505.ch2  0.88
2005 Fujita T, Brown C, Carlson EJ, Taylor T, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Fujita K, Castro R, Chen CW, Lin ET, Brett CM, Burchard EG, Ferrin TE, ... ... Giacomini KM, et al. Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). Pharmacogenetics and Genomics. 15: 201-9. PMID 15864112  0.88
2005 Owen RP, Gray JH, Taylor TR, Carlson EJ, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, Giacomini KM. Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2. Pharmacogenetics and Genomics. 15: 83-90. PMID 15861032  0.88
2005 Ferrin TE, Huang CC, Greenblatt DM, Stryke D, Giacomini KM, Morris JH. Enhancing data sharing in collaborative research projects with DASH. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 260-71. PMID 15759632  0.88
2005 Badagnani I, Chan W, Castro RA, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM. Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3). The Pharmacogenomics Journal. 5: 157-65. PMID 15738947 DOI: 10.1038/sj.tpj.6500303  0.88
2005 Urban TJ, Giacomini KM, Risch N. Haplotype structure and ethnic-specific allele frequencies at the OCTN locus: implications for the genetics of Crohn's disease. Inflammatory Bowel Diseases. 11: 78-9. PMID 15674120 DOI: 10.1097/00054725-200501000-00014  0.88
2004 Shu Y, Leabman MK, Feng B, Mangravite LM, Huang CC, Stryke D, Kawamoto M, Johns SJ, DeYoung J, Carlson E, Ferrin TE, Herskowitz I, Giacomini KM. PharmGKB update: III. Genetic variants of SLC22A1, solute carrier family 22 (organic cation transporter), member 1. Pharmacological Reviews. 56: 161. PMID 15169925 DOI: 10.1124/pr.56.2.2  0.88
2004 Gray JH, Mangravite LM, Owen RP, Urban TJ, Chan W, Carlson EJ, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, Giacomini KM. Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations. Molecular Pharmacology. 65: 512-9. PMID 14978229 DOI: 10.1124/mol.65.3.512  0.88
2004 Gray JH, Owen RP, Giacomini KM. The concentrative nucleoside transporter family, SLC28. PflüGers Archiv : European Journal of Physiology. 447: 728-34. PMID 12856181 DOI: 10.1007/s00424-003-1107-y  0.88
2003 Mangravite LM, Badagnani I, Giacomini KM. Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney. European Journal of Pharmacology. 479: 269-81. PMID 14612157 DOI: 10.1016/j.ejphar.2003.08.076  0.88
2003 Leabman MK, Giacomini KM. Estimating the contribution of genes and environment to variation in renal drug clearance. Pharmacogenetics. 13: 581-4. PMID 12972957 DOI: 10.1097/01.fpc.0000054111.14659.2b  0.88
2003 Kroetz DL, Pauli-Magnus C, Hodges LM, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, DeYoung J, Taylor T, Carlson EJ, Herskowitz I, Giacomini KM, Clark AG. Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene. Pharmacogenetics. 13: 481-94. PMID 12893986 DOI: 10.1097/01.fpc.0000054113.14659.b9  0.88
2003 Leabman MK, Huang CC, Stryke D, Johns SJ, Kawamoto M, Ferrin TE, DeYoung J, Taylor TR, De La Cruz M, Herskowitz I, Giacomini KM. PharmGKB update: I. Genetic variants of the organic cation transporter 2 (OCT2, SLC22A2). Pharmacological Reviews. 55: 399. PMID 12869664 DOI: 10.1124/pr.55.3.6  0.88
2003 Osato DH, Huang CC, Kawamoto M, Johns SJ, Stryke D, Wang J, Ferrin TE, Herskowitz I, Giacomini KM. Functional characterization in yeast of genetic variants in the human equilibrative nucleoside transporter, ENT1. Pharmacogenetics. 13: 297-301. PMID 12724623 DOI: 10.1097/01.fpc.0000054083.64000.2a  0.88
2003 Shu Y, Leabman MK, Feng B, Mangravite LM, Huang CC, Stryke D, Kawamoto M, Johns SJ, DeYoung J, Carlson E, Ferrin TE, Herskowitz I, Giacomini KM. Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1. Proceedings of the National Academy of Sciences of the United States of America. 100: 5902-7. PMID 12719534 DOI: 10.1073/pnas.0730858100  0.88
2003 Leabman MK, Huang CC, DeYoung J, Carlson EJ, Taylor TR, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Urban TJ, Kroetz DL, Ferrin TE, Clark AG, Risch N, Herskowitz I, ... Giacomini KM, et al. Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proceedings of the National Academy of Sciences of the United States of America. 100: 5896-901. PMID 12719533 DOI: 10.1073/pnas.0730857100  0.88
2003 Mangravite LM, Giacomini KM. Sorting of rat SPNT in renal epithelium is independent of N-glycosylation. Pharmaceutical Research. 20: 319-23. PMID 12636174 DOI: 10.1023/A:1022247826750  0.88
2003 Stryke D, Huang CC, Kawamoto M, Johns SJ, Carlson EJ, Deyoung JA, Leabman MK, Herskowitz I, Giacomini KM, Ferrin TE. SNP analysis and presentation in the Pharmacogenetics of Membrane Transporters Project. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 535-47. PMID 12603056  0.88
2003 Mangravite LM, Xiao G, Giacomini KM. Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells. American Journal of Physiology. Renal Physiology. 284: F902-10. PMID 12527552 DOI: 10.1152/ajprenal.00215.2002  0.88
2002 Dresser MJ, Xiao G, Leabman MK, Gray AT, Giacomini KM. Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2). Pharmaceutical Research. 19: 1244-7. PMID 12240953 DOI: 10.1023/A:1019870831174  0.88
2002 Leabman MK, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, DeYoung J, Taylor T, Clark AG, Herskowitz I, Giacomini KM. Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function. Pharmacogenetics. 12: 395-405. PMID 12142729 DOI: 10.1097/00008571-200207000-00007  0.88
2002 Gerstin KM, Dresser MJ, Giacomini KM. Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT. American Journal of Physiology. Renal Physiology. 283: F344-9. PMID 12110519 DOI: 10.1152/ajprenal.00274.2001  0.88
2002 Feng B, Shu Y, Giacomini KM. Role of aromatic transmembrane residues of the organic anion transporter, rOAT3, in substrate recognition. Biochemistry. 41: 8941-7. PMID 12102636 DOI: 10.1021/bi0200615  0.88
2001 Shu Y, Bello CL, Mangravite LM, Feng B, Giacomini KM. Functional characteristics and steroid hormone-mediated regulation of an organic cation transporter in Madin-Darby canine kidney cells. The Journal of Pharmacology and Experimental Therapeutics. 299: 392-8. PMID 11561104  0.88
2001 Feng B, Dresser MJ, Shu Y, Johns SJ, Giacomini KM. Arginine 454 and lysine 370 are essential for the anion specificity of the organic anion transporter, rOAT3. Biochemistry. 40: 5511-20. PMID 11331016 DOI: 10.1021/bi002841o  0.88
2001 Mangravite LM, Lipschutz JH, Mostov KE, Giacomini KM. Localization of GFP-tagged concentrative nucleoside transporters in a renal polarized epithelial cell line. American Journal of Physiology. Renal Physiology. 280: F879-85. PMID 11292631  0.88
2001 Glatt CE, DeYoung JA, Delgado S, Service SK, Giacomini KM, Edwards RH, Risch N, Freimer NB. Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes. Nature Genetics. 27: 435-8. PMID 11279528 DOI: 10.1038/86948  0.88
2001 Dresser MJ, Leabman MK, Giacomini KM. Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters. Journal of Pharmaceutical Sciences. 90: 397-421. PMID 11170032 DOI: 10.1002/1520-6017(200104)90:4<397::AID-JPS1000>3.0.CO;2-D  0.88
2001 Xiao G, Wang J, Tangen T, Giacomini KM. A novel proton-dependent nucleoside transporter, CeCNT3, from Caenorhabditis elegans Molecular Pharmacology. 59: 339-348. PMID 11160871  0.88
2001 Pauli-Magnus C, DeYoung J, Herskowitz I, Giacomini KM, Kroetz DL. Ethnic differences in the allele frequency of polymorphisms in the MDR1 gene Clinical Pharmacology and Therapeutics. 69: P75.  0.88
2000 Gerstin KM, Dresser MJ, Wang J, Giacomini KM. Molecular cloning of a Na+-dependent nucleoside transporter from rabbit intestine. Pharmaceutical Research. 17: 906-10. PMID 11028933 DOI: 10.1023/A:1007510801253  0.88
2000 Dresser MJ, Gerstin KM, Gray AT, Loo DD, Giacomini KM. Electrophysiological analysis of the substrate selectivity of a sodium-coupled nucleoside transporter (rCNT1) expressed in Xenopus laevis oocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 28: 1135-40. PMID 10950861  0.88
2000 Dresser MJ, Gray AT, Giacomini KM. Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1). The Journal of Pharmacology and Experimental Therapeutics. 292: 1146-52. PMID 10688634  0.88
2000 Zhang L, Gorset W, Washington CB, Blaschke TF, Kroetz DL, Giacomini KM. Interactions of HIV protease inhibitors with a human organic cation transporter in a mammalian expression system. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 28: 329-34. PMID 10681378  0.88
1999 Schaner ME, Gerstin KM, Wang J, Giacomini KM. Mechanisms of transport of nucleosides and nucleoside analogues in choroid plexus. Advanced Drug Delivery Reviews. 39: 51-62. PMID 10837767 DOI: 10.1016/S0169-409X(99)00019-8  0.88
1999 Dresser MJ, Zhang L, Giacomini KM. Molecular and functional characteristics of cloned human organic cation transporters. Pharmaceutical Biotechnology. 12: 441-69. PMID 10742984  0.88
1999 Schaner ME, Wang J, Zhang L, Su SF, Gerstin KM, Giacomini KM. Functional characterization of a human purine-selective, Na+-dependent nucleoside transporter (hSPNT1) in a mammalian expression system. The Journal of Pharmacology and Experimental Therapeutics. 289: 1487-91. PMID 10336543  0.88
1999 Zhang L, Gorset W, Dresser MJ, Giacomini KM. The interaction of n-tetraalkylammonium compounds with a human organic cation transporter, hOCT1. The Journal of Pharmacology and Experimental Therapeutics. 288: 1192-8. PMID 10027858  0.88
1999 Wang J, Giacomini KM. Characterization of a bioengineered chimeric Na+-nucleoside transporter Molecular Pharmacology. 55: 234-240. PMID 9927613  0.88
1999 Wang J, Giacomini KM. Serine 318 is essential for the pyrimidine selectivity of the N2 Na+- nucleoside transporter Journal of Biological Chemistry. 274: 2298-2302. PMID 9890994 DOI: 10.1074/jbc.274.4.2298  0.88
1998 Washington CB, Giacomini KM, Brett CM. Nucleoside transport in isolated human and rhesus choroid plexus tissue slices. Pharmaceutical Research. 15: 1145-7. PMID 9688074 DOI: 10.1023/A:1011963102063  0.88
1998 Zhang L, Schaner ME, Giacomini KM. Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa) Journal of Pharmacology and Experimental Therapeutics. 286: 354-361. PMID 9655880  0.88
1998 Zevin S, Schaner ME, Giacomini KM. Nicotine transport in a human choriocarcinoma cell line (JAR) Journal of Pharmaceutical Sciences. 87: 702-706. PMID 9607946 DOI: 10.1021/js970455v  0.88
1998 Zhang L, Brett CM, Giacomini KM. Role of organic cation transporters in drug absorption and elimination. Annual Review of Pharmacology and Toxicology. 38: 431-60. PMID 9597162 DOI: 10.1146/annurev.pharmtox.38.1.431  0.88
1998 Terashita S, Dresser MJ, Zhang L, Gray AT, Yost SC, Giacomini KM. Molecular cloning and functional expression of a rabbit renal organic cation transporter. Biochimica Et Biophysica Acta. 1369: 1-6. PMID 9528667 DOI: 10.1016/S0005-2736(97)00207-1  0.88
1998 Schaner ME, Wang J, Zhang L, Su S, Giacomini KM. Characterization of a Human Purine-Selective Nucleoside Transporter (hSPNT) in transfected cells Faseb Journal. 12: A1017.  0.88
1998 Wang J, Schaner ME, Giacomini KM. Structural determinants of substrate selectivity in Na+-dependent nucleoside transporters Faseb Journal. 12: A826.  0.88
1998 Zhang L, Schaner ME, Giacomini KM. Functional characterization of a human organic cation transporter (hOCT1) in a mammalian cell line (HeLa) Faseb Journal. 12: A1017.  0.88
1997 Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM. Na-dependent purine nucleoside transporter from human kidney: cloning and functional characterization. American Journal of Physiology. Renal Physiology. 273: F1058-F1065. PMID 29586101 DOI: 10.1152/ajprenal.1997.273.6.F1058  0.88
1997 Giacomini KM. Membrane transporters in drug disposition Journal of Pharmacokinetics and Biopharmaceutics. 25: 731-741. PMID 9697080 DOI: 10.1023/A:1025733918160  0.88
1997 Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM. Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization. The American Journal of Physiology. 273: F1058-65. PMID 9435697  0.88
1997 Wang J, Schaner ME, Thomassen S, Su SF, Piquette-Miller M, Giacomini KM. Functional and molecular characteristics of Na(+)-dependent nucleoside transporters. Pharmaceutical Research. 14: 1524-32. PMID 9434270 DOI: 10.1023/A:1012113931332  0.88
1997 Ramanathan VK, Brett CM, Giacomini KM. Na+-dependent gamma-aminobutyric acid (GABA) transport in the choroid plexus of rabbit. Biochimica Et Biophysica Acta. 1330: 94-102. PMID 9375816 DOI: 10.1016/S0005-2736(97)00146-6  0.88
1997 Wang J, Giacomini KM. Molecular determinants of substrate selectivity in Na+-dependent nucleoside transporters Journal of Biological Chemistry. 272: 28845-28848. PMID 9360950 DOI: 10.1074/jbc.272.46.28845  0.88
1997 Schaner ME, Wang J, Zevin S, Gerstin KM, Giacomini KM. Transient expression of a purine-selective nucleoside transporter (SPNTint) in a human cell line (HeLa). Pharmaceutical Research. 14: 1316-21. PMID 9358542 DOI: 10.1023/A:1012148016794  0.88
1997 Chun JK, Zhang L, Piquette-Miller M, Lau E, Tong LQ, Giacomini KM. Characterization of guanidine transport in human renal brush border membranes Pharmaceutical Research. 14: 936-941. PMID 9244153 DOI: 10.1023/A:1012164203648  0.88
1997 Zhang L, Dresser MJ, Chun JK, Babbitt PC, Giacomini KM. Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A). The Journal of Biological Chemistry. 272: 16548-54. PMID 9195965 DOI: 10.1074/jbc.272.26.16548  0.88
1997 Chun JK, Piquette-Miller M, Zhang L, Giacomini KM. Expression of human polyspecific renal organic cation transport activity in Xenopus laevis oocytes Journal of Pharmaceutical Sciences. 86: 753-755. PMID 9188060 DOI: 10.1021/js960509l  0.88
1997 Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM. Cloning and functional expression of a human liver organic cation transporter. Molecular Pharmacology. 51: 913-21. PMID 9187257  0.88
1997 Ramanathan VK, Chung SJ, Giacomini KM, Brett CM. Taurine transport in cultured choroid plexus. Pharmaceutical Research. 14: 406-9. PMID 9144722 DOI: 10.1023/A:1012074827388  0.88
1997 Zevin S, Schaner ME, Illsley NP, Giacomini KM. Guanidine transport in a human choriocarcinoma cell line (JAR) Pharmaceutical Research. 14: 401-405. PMID 9144721 DOI: 10.1023/A:1012022810550  0.88
1997 Zhang L, Dresser MJ, Chun JK, Babbitt PC, Giacomini KM. Cloning and functional expression of a polyspecific organic cation transporter (OCT3) from rat kidney Clinical Pharmacology and Therapeutics. 61: 235.  0.88
1996 Washington CB, Giacomini KM. Mechanisms of 5-fluorouracil (5-FU) transport in isolated rabbit choroid plexus tissue slices Pharmaceutical Research. 13: 1276-1278. PMID 8865326 DOI: 10.1023/A:1016041009856  0.88
1996 Ramanathan VK, Hui AC, Brett CM, Giacomini KM. Primary cell culture of the rabbit choroid plexus: an experimental system to investigate membrane transport. Pharmaceutical Research. 13: 952-6. PMID 8792439 DOI: 10.1023/A:1016029918091  0.88
1996 Washington CB, Giacomini KM, Brett CM. Methods of study drug transport in isolated choroid plexus tissue and cultured cells. Pharmaceutical Biotechnology. 8: 259-83. PMID 8791814  0.88
1996 Gutierrez MM, Brett CM, Giacomini KM. Isolated renal brush border and basolateral membrane vesicles and cultured renal cells. Pharmaceutical Biotechnology. 8: 193-210. PMID 8791811  0.88
1995 Washington CB, Giacomini KM. Mechanisms of nucleobase transport in rabbit choroid plexus: Evidence for a Na+-dependent nucleobase transporter with broad substrate selectivity Journal of Biological Chemistry. 270: 22816-22819. PMID 7559412 DOI: 10.1074/jbc.270.39.22816  0.88
1994 Wu X, Gutierrez MM, Giacomini KM. Further characterization of the sodium-dependent nucleoside transporter (N3) in choroid plexus from rabbit Bba - Biomembranes. 1191: 190-196. PMID 8155674 DOI: 10.1016/0005-2736(94)90248-8  0.88
1994 Gutierrez MM, Giacomini KM. Expression of a human renal sodium nucleoside contransporter in Xenopus laevis oocytes Biochemical Pharmacology. 48: 2251-2253. PMID 7811307 DOI: 10.1016/0006-2952(94)00411-0  0.88
1993 Wu X, Hui AC, Giacomini KM. Formycin B Elimination from the Cerebrospinal Fluid of the Rat Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 10: 611-615. PMID 8483848 DOI: 10.1023/A:1018970607728  0.88
1993 Brett CM, Washington CB, Ott RJ, Gutierrez MM, Giacomini KM. Interaction of nucleoside analogues with the sodium-nucleoside transport system in brush border membrane vesicles from human kidney. Pharmaceutical Research. 10: 423-6. PMID 8464817 DOI: 10.1023/A:1018948608211  0.88
1993 Gutierrez MM, Giacomini KM. Substrate selectivity, potential sensitivity and stoichiometry of Na+-nucleoside transport in brush border membrane vesicles from human kidney Bba - Biomembranes. 1149: 202-208. PMID 8323939 DOI: 10.1016/0005-2736(93)90202-B  0.88
1992 Gutierrez MM, Brett CM, Ott RJ, Hui AC, Giacomini KM. Nucleoside transport in brush border membrane vesicles from human kidney. Biochimica Et Biophysica Acta. 1105: 1-9. PMID 1567888 DOI: 10.1016/0005-2736(92)90156-G  0.88
1990 Levy G, Amidon GL, Benet LZ, Borchardt RT, Brouwer KR, Fung HL, Giacomini KM, Kroboth PD, Repta AJ, Robinson JR, Slattery JT, Lee VHL, Breimer D, Sezaki H. Academic pharmaceutics: The challenge of excellence Pharmaceutical Research. 7: 782-785. PMID 2395809 DOI: 10.1023/A:1015844411943  0.88
1988 Valdivieso L, Giacomini KM, Nelson WL, Pershe R, Blaschke TF. Stereoselective binding of disopyramide to plasma proteins Pharmaceutical Research. 5: 316-318. PMID 3244643 DOI: 10.1023/A:1015986906627  0.88
1988 Boyd RA, Giacomini JC, Giacomini KM. Species differences in the negative inotropic response of 1,4-dihydropyridine calcium channel blockers in myocardium Journal of Cardiovascular Pharmacology. 12: 650-657. PMID 2467082 DOI: 10.1097/00005344-198812000-00005  0.88
1986 Zobrist RH, Giacomini KM, Nelson WL, Giacomini JC. The interaction of phenylalkylamine calcium channel blockers with the 1,4-dihydropyridine binding site Journal of Molecular and Cellular Cardiology. 18: 963-974. PMID 3783730 DOI: 10.1016/S0022-2828(86)80010-4  0.88
1986 Giacomini KM, Nelson WL, Pershe RA, Valdivieso L, Turner-Tamiyasu K, Blaschke TF. In vivo interaction of the enantiomers of disopyramide in human subjects Journal of Pharmacokinetics and Biopharmaceutics. 14: 335-356. PMID 3772736 DOI: 10.1007/BF01059195  0.88
1986 Theodore LJ, Nelson WL, Zobrist RH, Giacomini KM, Giacomini JC. Studies on Ca2+ channel antagonists. 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2- isopropylpentyl isothiocyanate, a chemoaffinity ligand derived from verapamil Journal of Medicinal Chemistry. 29: 1789-1792. PMID 2427721 DOI: 10.1021/jm00159a040  0.88
1985 Giacomini JC, Giacomini KM, Nelson WL, Harrison DC, Blaschke TF. Electrophysiology of the enantiomers of disopyramide in dogs. Journal of Cardiovascular Pharmacology. 7: 884-90. PMID 2413296 DOI: 10.1097/00005344-198509000-00011  0.88
1985 Giacomini JC, Nelson WL, Theodore L, Mi Wong F, Rood D, Giacomini KM. The pharmacokinetics and pharmacodynamics of d- and dl-verapamil in rabbits Journal of Cardiovascular Pharmacology. 7: 469-475. PMID 2410676 DOI: 10.1097/00005344-198505000-00009  0.88
1985 Giacomini JC, Zobrist RH, Dave B, Giacomini KM. Verapamil Interacts Stereoselectively with the Muscarinic Receptor Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 2: 94-95. DOI: 10.1023/A:1016351014051  0.88
1984 Giacomini KM, Wong FM, Tozer TN. Correction for Volume Shift during Equilibrium Dialysis by Measurement of Protein Concentration. Pharmaceutical Research. 1: 179-81. PMID 24277288 DOI: 10.1023/A:1016352725805  0.88
1984 Smith GA, Giacomini KM, Smith CT, Gregory PB, Robinson WS, Merigan TC, Blaschke TF. High-performance liquid chromatographic analysis of hypoxanthine arabinoside in plasma. Journal of Chromatography. 307: 410-5. PMID 6203924 DOI: 10.1016/S0378-4347(00)84114-6  0.88
1983 Schulz P, Giacomini KM, Luttrell S, Turner-Tamiyasu K, Blaschke TF. Effect of low doses of heparin on the plasma binding of phenytoin and prazosin in normal man European Journal of Clinical Pharmacology. 25: 211-214. PMID 6628503 DOI: 10.1007/BF00543793  0.88
1982 Pollick C, Giacomini KM, Blaschke TF, Nelson WL, Turner-Tamiyasu K, Briskin V, Popp RL. The cardiac effects of d- and l-disopyramide in normal subjects: A noninvasive study Circulation. 66: 447-453. PMID 7094252 DOI: 10.1161/01.CIR.66.2.447  0.88
1981 Nelson WL, Sneed CK, Giacomini KM, Giacomini JC, Stauss J, Blaschke TF, Cox BM. Synthesis and anticholinergic properties of the enantiomers of 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide, the mono-N-dealkylated metabolite of disopyramide. Journal of Medicinal Chemistry. 24: 614-7. PMID 7241519 DOI: 10.1021/jm00137a024  0.88
1980 Giacomini KM, Giacomini JC, Swezey SE, Harrison DC, Nelson WL, Burke TR, Blaschke TF. The stereoselective disposition of disopyramide in the dog Journal of Cardiovascular Pharmacology. 2: 825-832. PMID 6160331 DOI: 10.1097/00005344-198011000-00011  0.88
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