Norman E. Sharpless - Publications

Genetics & Molecular Biology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Genetics, Molecular Biology

138 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Liu JY, Souroullas GP, Diekman BO, Krishnamurthy J, Hall BM, Sorrentino JA, Parker JS, Sessions GA, Gudkov AV, Sharpless NE. Cells exhibiting strong promoter activation in vivo display features of senescence. Proceedings of the National Academy of Sciences of the United States of America. PMID 30683717 DOI: 10.1073/pnas.1818313116  0.56
2018 Zhao X, Little P, Hoyle AP, Pegna GJ, Hayward MC, Ivanova A, Parker JS, Marron DL, Soloway MG, Jo H, Salazar AH, Papakonstantinou MP, Bouchard DM, Jefferys SR, Hoadley KA, ... ... Sharpless NE, et al. The Prognostic Significance of Low-Frequency Somatic Mutations in Metastatic Cutaneous Melanoma. Frontiers in Oncology. 8: 584. PMID 30662871 DOI: 10.3389/fonc.2018.00584  0.36
2017 Patel NM, Michelini VV, Snell JM, Balu S, Hoyle AP, Parker JS, Hayward MC, Eberhard DA, Salazar AH, McNeillie P, Xu J, Huettner CS, Koyama T, Utro F, Rhrissorrakrai K, ... ... Sharpless NE, et al. Enhancing Next-Generation Sequencing-Guided Cancer Care Through Cognitive Computing. The Oncologist. PMID 29158372 DOI: 10.1634/theoncologist.2017-0170  0.36
2017 Liu W, Snell JM, Jeck WR, Hoadley KA, Wilkerson MD, Parker JS, Patel N, Mlombe YB, Mulima G, Liomba NG, Wolf LL, Shores CG, Gopal S, Sharpless NE. Subtyping sub-Saharan esophageal squamous cell carcinoma by comprehensive molecular analysis. Jci Insight. 2. PMID 29148985 DOI: 10.1172/jci.insight.98457  0.48
2017 Deng J, Wang ES, Jenkins RW, Li S, Dries R, Yates K, Chhabra S, Huang W, Liu H, Aref AR, Ivanova E, Paweletz CP, Bowden M, Zhou CW, Herter-Sprie GS, ... ... Sharpless NE, et al. CDK4/6 Inhibition Augments Anti-Tumor Immunity by Enhancing T Cell Activation. Cancer Discovery. PMID 29101163 DOI: 10.1158/2159-8290.CD-17-0915  0.56
2017 Zhang H, Brainson CF, Koyama S, Redig AJ, Chen T, Li S, Gupta M, Garcia-de-Alba C, Paschini M, Herter-Sprie GS, Lu G, Zhang X, Marsh BP, Tuminello SJ, Xu C, ... ... Sharpless NE, et al. Erratum: Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2. Nature Communications. 8: 15901. PMID 28598439 DOI: 10.1038/ncomms15901  0.36
2017 He S, Roberts PJ, Sorrentino JA, Bisi JE, Storrie-White H, Tiessen RG, Makhuli KM, Wargin WA, Tadema H, van Hoogdalem EJ, Strum JC, Malik R, Sharpless NE. Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion. Science Translational Medicine. 9. PMID 28446688 DOI: 10.1126/scitranslmed.aal3986  0.56
2017 Zhang H, Fillmore Brainson C, Koyama S, Redig AJ, Chen T, Li S, Gupta M, Garcia-de-Alba C, Paschini M, Herter-Sprie GS, Lu G, Zhang X, Marsh BP, Tuminello SJ, Xu C, ... ... Sharpless NE, et al. Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2. Nature Communications. 8: 14922. PMID 28387316 DOI: 10.1038/ncomms14922  0.36
2016 Liu W, Snell JM, Jeck WR, Hoadley KA, Wilkerson MD, Parker JS, Patel N, Mlombe YB, Mulima G, Liomba NG, Wolf LL, Shores CG, Gopal S, Sharpless NE. Subtyping sub-Saharan esophageal squamous cell carcinoma by comprehensive molecular analysis. Jci Insight. 1: e88755. PMID 27734031 DOI: 10.1172/jci.insight.88755  0.48
2016 King SJ, Asokan SB, Haynes EM, Zimmerman SP, Rotty JD, Alb JG, Tagliatela A, Blake DR, Lebedeva IP, Marston D, Johnson HE, Parsons M, Sharpless NE, Kuhlman B, Haugh JM, et al. Lamellipodia are critical for haptotactic sensing and response. Journal of Cell Science. PMID 27173494 DOI: 10.1242/jcs.184507  0.96
2016 Souroullas GP, Jeck WR, Parker JS, Simon JM, Liu JY, Paulk J, Xiong J, Clark KS, Fedoriw Y, Qi J, Burd CE, Bradner JE, Sharpless NE. An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation. Nature Medicine. PMID 27135738 DOI: 10.1038/nm.4092  0.96
2016 Seifert BA, O'Daniel JM, Amin K, Marchuk DS, Patel NM, Parker JS, Hoyle AP, Mose LE, Marron A, Hayward MC, Bizon C, Wilhelmsen KC, Evans JP, Earp HS, Sharpless N, et al. Germline Analysis from Tumor-Germline Sequencing Dyads to identify clinically actionable secondary findings. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27083775 DOI: 10.1158/1078-0432.CCR-16-0015  0.96
2015 Pustavoitau A, Barodka V, Sharpless NE, Torrice C, Nyhan D, Berkowitz DE, Shah AS, Bandeen Roche KJ, Walston JD. Role of senescence marker p16(INK4a) measured in peripheral blood T-lymphocytes in predicting length of hospital stay after coronary artery bypass surgery in older adults. Experimental Gerontology. 74: 29-36. PMID 26692418 DOI: 10.1016/j.exger.2015.12.003  0.96
2015 Chang J, Wang Y, Shao L, Laberge RM, Demaria M, Campisi J, Janakiraman K, Sharpless NE, Ding S, Feng W, Luo Y, Wang X, Aykin-Burns N, Krager K, Ponnappan U, et al. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nature Medicine. PMID 26657143 DOI: 10.1038/nm.4010  0.96
2015 Montgomery ND, Parker JS, Eberhard DA, Patel NM, Weck KE, Sharpless NE, Hu Z, Hayes DN, Gulley ML. Identification of Human Papillomavirus Infection in Cancer Tissue by Targeted Next-generation Sequencing. Applied Immunohistochemistry & Molecular Morphology : Aimm / Official Publication of the Society For Applied Immunohistochemistry. PMID 26371432 DOI: 10.1097/PAI.0000000000000215  0.96
2015 Sharpless NE, Sherr CJ. Forging a signature of in vivo senescence. Nature Reviews. Cancer. 15: 397-408. PMID 26105537 DOI: 10.1038/nrc3960  0.96
2015 Zhao X, Wang A, Walter V, Patel NM, Eberhard DA, Hayward MC, Salazar AH, Jo H, Soloway MG, Wilkerson MD, Parker JS, Yin X, Zhang G, Siegel MB, Rosson GB, ... ... Sharpless NE, et al. Combined Targeted DNA Sequencing in Non-Small Cell Lung Cancer (NSCLC) Using UNCseq and NGScopy, and RNA Sequencing Using UNCqeR for the Detection of Genetic Aberrations in NSCLC. Plos One. 10: e0129280. PMID 26076459 DOI: 10.1371/journal.pone.0129280  0.96
2015 Carson CC, Moschos SJ, Edmiston SN, Darr DB, Nikolaishvili-Feinberg N, Groben PA, Zhou X, Kuan PF, Pandey S, Chan KT, Jordan JL, Hao H, Frank JS, Hopkinson DA, Gibbs DC, ... ... Sharpless NE, et al. IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 2167-76. PMID 25934889 DOI: 10.1158/1078-0432.CCR-14-1826  0.96
2015 Souroullas GP, Sharpless NE. mTOR signaling in melanoma: oncogene-induced pseudo-senescence? Cancer Cell. 27: 3-5. PMID 25584887 DOI: 10.1016/j.ccell.2014.12.005  0.96
2015 Sharpless NE, Sherr CJ. Forging a signature of in vivo senescence (Nature Reviews Cancer (2015) 15:(397-408)) Nature Reviews Cancer. 15: 509. DOI: 10.1038/nrc3988  0.96
2015 Sharpless NE, He S. The Impact of Aging on Cancer Progression and Treatment Advances in Geroscience. 53-83. DOI: 10.1007/978-3-319-23246-1_3  0.96
2014 Chan KT, Asokan SB, King SJ, Bo T, Dubose ES, Liu W, Berginski ME, Simon JM, Davis IJ, Gomez SM, Sharpless NE, Bear JE. LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues. The Journal of Cell Biology. 207: 299-315. PMID 25349262 DOI: 10.1083/jcb.201404067  0.96
2014 Burd CE, Liu W, Huynh MV, Waqas MA, Gillahan JE, Clark KS, Fu K, Martin BL, Jeck WR, Souroullas GP, Darr DB, Zedek DC, Miley MJ, Baguley BC, Campbell SL, ... Sharpless NE, et al. Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma. Cancer Discovery. 4: 1418-29. PMID 25252692 DOI: 10.1158/2159-8290.CD-14-0729  0.96
2014 Zhao N, Wilkerson MD, Shah U, Yin X, Wang A, Hayward MC, Roberts P, Lee CB, Parsons AM, Thorne LB, Haithcock BE, Grilley-Olson JE, Stinchcombe TE, Funkhouser WK, Wong KK, ... Sharpless NE, et al. Alterations of LKB1 and KRAS and risk of brain metastasis: comprehensive characterization by mutation analysis, copy number, and gene expression in non-small-cell lung carcinoma. Lung Cancer (Amsterdam, Netherlands). 86: 255-61. PMID 25224251 DOI: 10.1016/j.lungcan.2014.08.013  0.96
2014 Sorrentino JA, Sanoff HK, Sharpless NE. Defining the toxicology of aging. Trends in Molecular Medicine. 20: 375-84. PMID 24880613 DOI: 10.1016/j.molmed.2014.04.004  0.96
2014 Jeck WR, Sharpless NE. Detecting and characterizing circular RNAs. Nature Biotechnology. 32: 453-61. PMID 24811520 DOI: 10.1038/nbt.2890  0.96
2014 Sanoff HK, Deal AM, Krishnamurthy J, Torrice C, Dillon P, Sorrentino J, Ibrahim JG, Jolly TA, Williams G, Carey LA, Drobish A, Gordon BB, Alston S, Hurria A, Kleinhans K, ... ... Sharpless NE, et al. Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer. Journal of the National Cancer Institute. 106: dju057. PMID 24681605 DOI: 10.1093/jnci/dju057  0.96
2014 Jeck WR, Parker J, Carson CC, Shields JM, Sambade MJ, Peters EC, Burd CE, Thomas NE, Chiang DY, Liu W, Eberhard DA, Ollila D, Grilley-Olson J, Moschos S, Neil Hayes D, ... Sharpless NE, et al. Targeted next generation sequencing identifies clinically actionable mutations in patients with melanoma. Pigment Cell & Melanoma Research. 27: 653-63. PMID 24628946 DOI: 10.1111/pcmr.12238  0.96
2014 Shao L, Feng W, Li H, Gardner D, Luo Y, Wang Y, Liu L, Meng A, Sharpless NE, Zhou D. Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner. Blood. 123: 3105-15. PMID 24622326 DOI: 10.1182/blood-2013-07-515619  0.96
2014 Sorrentino JA, Krishnamurthy J, Tilley S, Alb JG, Burd CE, Sharpless NE. p16INK4a reporter mice reveal age-promoting effects of environmental toxicants. The Journal of Clinical Investigation. 124: 169-73. PMID 24334456 DOI: 10.1172/JCI70960  0.96
2014 Chen Z, Akbay E, Mikse O, Tupper T, Cheng K, Wang Y, Tan X, Altabef A, Woo SA, Chen L, Reibel JB, Janne PA, Sharpless NE, Engelman JA, Shapiro GI, et al. Co-clinical trials demonstrate superiority of crizotinib to chemotherapy in ALK-rearranged non-small cell lung cancer and predict strategies to overcome resistance. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 1204-11. PMID 24327273 DOI: 10.1158/1078-0432.CCR-13-1733  0.96
2013 Wu C, Haynes EM, Asokan SB, Simon JM, Sharpless NE, Baldwin AS, Davis IJ, Johnson GL, Bear JE. Loss of Arp2/3 induces an NF-κB-dependent, nonautonomous effect on chemotactic signaling. The Journal of Cell Biology. 203: 907-16. PMID 24344184 DOI: 10.1083/jcb.201306032  0.96
2013 Nakada Y, Stewart TG, Peña CG, Zhang S, Zhao N, Bardeesy N, Sharpless NE, Wong KK, Hayes DN, Castrillon DH. The LKB1 tumor suppressor as a biomarker in mouse and human tissues. Plos One. 8: e73449. PMID 24086281 DOI: 10.1371/journal.pone.0073449  0.96
2013 Souroullas GP, Sharpless NE. Stem cells: Down's syndrome link to ageing. Nature. 501: 325-6. PMID 24025769 DOI: 10.1038/nature12558  0.96
2013 Usary J, Zhao W, Darr D, Roberts PJ, Liu M, Balletta L, Karginova O, Jordan J, Combest A, Bridges A, Prat A, Cheang MC, Herschkowitz JI, Rosen JM, Zamboni W, ... Sharpless NE, et al. Predicting drug responsiveness in human cancers using genetically engineered mice. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 4889-99. PMID 23780888 DOI: 10.1158/1078-0432.CCR-13-0522  0.96
2013 Liu Y, Marks K, Cowley GS, Carretero J, Liu Q, Nieland TJ, Xu C, Cohoon TJ, Gao P, Zhang Y, Chen Z, Altabef AB, Tchaicha JH, Wang X, Choe S, ... ... Sharpless NE, et al. Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. Cancer Discovery. 3: 870-9. PMID 23715154 DOI: 10.1158/2159-8290.CD-13-0015  0.96
2013 Newgard CB, Sharpless NE. Coming of age: molecular drivers of aging and therapeutic opportunities. The Journal of Clinical Investigation. 123: 946-50. PMID 23454756 DOI: 10.1172/JCI68833  0.96
2013 Burd CE, Sorrentino JA, Clark KS, Darr DB, Krishnamurthy J, Deal AM, Bardeesy N, Castrillon DH, Beach DH, Sharpless NE. Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model. Cell. 152: 340-51. PMID 23332765 DOI: 10.1016/j.cell.2012.12.010  0.96
2013 Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF, Sharpless NE. Circular RNAs are abundant, conserved, and associated with ALU repeats Rna. 19: 141-157. PMID 23249747 DOI: 10.1261/rna.035667.112  0.96
2012 Troy A, Sharpless NE. Genetic "lnc"-age of noncoding RNAs to human disease Journal of Clinical Investigation. 122: 3837-3840. PMID 23093789 DOI: 10.1172/JCI66645  0.96
2012 Combest AJ, Roberts PJ, Dillon PM, Sandison K, Hanna SK, Ross C, Habibi S, Zamboni B, Müller M, Brunner M, Sharpless NE, Zamboni WC. Genetically engineered cancer models, but not xenografts, faithfully predict anticancer drug exposure in melanoma tumors. The Oncologist. 17: 1303-16. PMID 22993143 DOI: 10.1634/theoncologist.2012-0274  0.96
2012 Liu W, Sharpless NE. Senescence-escape in melanoma. Pigment Cell & Melanoma Research. 25: 408-9. PMID 22900268 DOI: 10.1111/j.1755-148X.2012.01021.x  0.96
2012 Jeck WR, Siebold AP, Sharpless NE. Review: a meta-analysis of GWAS and age-associated diseases. Aging Cell. 11: 727-31. PMID 22888763 DOI: 10.1111/j.1474-9726.2012.00871.x  0.96
2012 Roberts PJ, Usary JE, Darr DB, Dillon PM, Pfefferle AD, Whittle MC, Duncan JS, Johnson SM, Combest AJ, Jin J, Zamboni WC, Johnson GL, Perou CM, Sharpless NE. Combined PI3K/mTOR and MEK inhibition provides broad antitumor activity in faithful murine cancer models. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 5290-303. PMID 22872574 DOI: 10.1158/1078-0432.CCR-12-0563  0.96
2012 Nelson JA, Krishnamurthy J, Menezes P, Liu Y, Hudgens MG, Sharpless NE, Eron JJ. Expression of p16(INK4a) as a biomarker of T-cell aging in HIV-infected patients prior to and during antiretroviral therapy. Aging Cell. 11: 916-8. PMID 22738669 DOI: 10.1111/j.1474-9726.2012.00856.x  0.96
2012 Liu W, Monahan KB, Pfefferle AD, Shimamura T, Sorrentino J, Chan KT, Roadcap DW, Ollila DW, Thomas NE, Castrillon DH, Miller CR, Perou CM, Wong KK, Bear JE, Sharpless NE. LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma. Cancer Cell. 21: 751-64. PMID 22698401 DOI: 10.1016/j.ccr.2012.03.048  0.96
2012 Duncan JS, Whittle MC, Nakamura K, Abell AN, Midland AA, Zawistowski JS, Johnson NL, Granger DA, Jordan NV, Darr DB, Usary J, Kuan PF, Smalley DM, Major B, He X, ... ... Sharpless NE, et al. Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer. Cell. 149: 307-21. PMID 22500798 DOI: 10.1016/j.cell.2012.02.053  0.96
2012 Chen Z, Cheng K, Walton Z, Wang Y, Ebi H, Shimamura T, Liu Y, Tupper T, Ouyang J, Li J, Gao P, Woo MS, Xu C, Yanagita M, Altabef A, ... ... Sharpless NE, et al. A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature. 483: 613-7. PMID 22425996 DOI: 10.1038/nature10937  0.96
2012 Wu C, Asokan SB, Berginski ME, Haynes EM, Sharpless NE, Griffith JD, Gomez SM, Bear JE. Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis. Cell. 148: 973-87. PMID 22385962 DOI: 10.1016/j.cell.2011.12.034  0.96
2012 Iraqi FA, Mahajne M, Salaymah Y, Sandovski H, Tayem H, Vered K, Balmer L, Hall M, Manship G, Morahan G, Pettit K, Scholten J, Tweedie K, Wallace A, Weerasekera L, ... ... Sharpless NE, et al. The genome architecture of the collaborative cross mouse genetic reference population Genetics. 190: 389-401. PMID 22345608 DOI: 10.1534/genetics.111.132639  0.96
2012 Roberts PJ, Bisi JE, Strum JC, Combest AJ, Darr DB, Usary JE, Zamboni WC, Wong KK, Perou CM, Sharpless NE. Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy. Journal of the National Cancer Institute. 104: 476-87. PMID 22302033 DOI: 10.1093/jnci/djs002  0.96
2012 Kim WY, Sharpless NE. Drug efficacy testing in mice. Current Topics in Microbiology and Immunology. 355: 19-38. PMID 21823029 DOI: 10.1007/82_2011_160  0.96
2011 Kuo CL, Murphy AJ, Sayers S, Li R, Yvan-Charvet L, Davis JZ, Krishnamurthy J, Liu Y, Puig O, Sharpless NE, Tall AR, Welch CL. Cdkn2a is an atherosclerosis modifier locus that regulates monocyte/macrophage proliferation. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 2483-92. PMID 21868699 DOI: 10.1161/ATVBAHA.111.234492  0.96
2011 Liu Y, Johnson SM, Fedoriw Y, Rogers AB, Yuan H, Krishnamurthy J, Sharpless NE. Expression of p16(INK4a) prevents cancer and promotes aging in lymphocytes. Blood. 117: 3257-67. PMID 21245485 DOI: 10.1182/blood-2010-09-304402  0.96
2011 Cardenas JC, Owens AP, Krishnamurthy J, Sharpless NE, Whinna HC, Church FC. Overexpression of the cell cycle inhibitor p16INK4a promotes a prothrombotic phenotype following vascular injury in mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 827-33. PMID 21233453 DOI: 10.1161/ATVBAHA.110.221721  0.96
2011 Carey LA, Sharpless NE. PARP and cancer--if it's broke, don't fix it. The New England Journal of Medicine. 364: 277-9. PMID 21208102 DOI: 10.1056/NEJMe1012546  0.96
2010 Burd CE, Jeck WR, Liu Y, Sanoff HK, Wang Z, Sharpless NE. Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk. Plos Genetics. 6: e1001233. PMID 21151960 DOI: 10.1371/journal.pgen.1001233  0.96
2010 Monahan KB, Rozenberg GI, Krishnamurthy J, Johnson SM, Liu W, Bradford MK, Horner J, Depinho RA, Sharpless NE. Somatic p16(INK4a) loss accelerates melanomagenesis. Oncogene. 29: 5809-17. PMID 20697345 DOI: 10.1038/onc.2010.314  0.96
2010 Rozenberg GI, Monahan KB, Torrice C, Bear JE, Sharpless NE. Metastasis in an orthotopic murine model of melanoma is independent of RAS/RAF mutation. Melanoma Research. 20: 361-71. PMID 20679910 DOI: 10.1097/CMR.0b013e328336ee17  0.96
2010 Sharpless NE. Hot topics in stem cells and self-renewal: 2010. Aging Cell. 9: 457-61. PMID 20579010 DOI: 10.1111/j.1474-9726.2010.00592.x  0.96
2010 Johnson SM, Torrice CD, Bell JF, Monahan KB, Jiang Q, Wang Y, Ramsey MR, Jin J, Wong KK, Su L, Zhou D, Sharpless NE. Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition. The Journal of Clinical Investigation. 120: 2528-36. PMID 20577054 DOI: 10.1172/JCI41402  0.96
2010 Carretero J, Shimamura T, Rikova K, Jackson AL, Wilkerson MD, Borgman CL, Buttarazzi MS, Sanofsky BA, McNamara KL, Brandstetter KA, Walton ZE, Gu TL, Silva JC, Crosby K, Shapiro GI, ... ... Sharpless NE, et al. Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors. Cancer Cell. 17: 547-59. PMID 20541700 DOI: 10.1016/j.ccr.2010.04.026  0.96
2010 Burd CE, Sharpless NE. What's so special about RB? Cancer Cell. 17: 313-4. PMID 20385355 DOI: 10.1016/j.ccr.2010.03.010  0.96
2010 Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, ... ... Sharpless NE, et al. Impact papers on aging in 2009. Aging. 2: 111-21. PMID 20351400 DOI: v2/n3/full/100132.html  0.96
2009 Tsygankov D, Liu Y, Sanoff HK, Sharpless NE, Elston TC. A quantitative model for age-dependent expression of the p16INK4a tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America. 106: 16562-7. PMID 19805338 DOI: 10.1073/pnas.0904405106  0.96
2009 Kim WY, Perera S, Zhou B, Carretero J, Yeh JJ, Heathcote SA, Jackson AL, Nikolinakos P, Ospina B, Naumov G, Brandstetter KA, Weigman VJ, Zaghlul S, Hayes DN, Padera RF, ... ... Sharpless NE, et al. HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice. The Journal of Clinical Investigation. 119: 2160-70. PMID 19662677 DOI: 10.1172/JCI38443  0.96
2009 Wong ES, Le Guezennec X, Demidov ON, Marshall NT, Wang ST, Krishnamurthy J, Sharpless NE, Dunn NR, Bulavin DV. p38MAPK controls expression of multiple cell cycle inhibitors and islet proliferation with advancing age. Developmental Cell. 17: 142-9. PMID 19619499 DOI: 10.1016/j.devcel.2009.05.009  0.96
2009 Liu Y, Sharpless NE. Tumor suppressor mechanisms in immune aging. Current Opinion in Immunology. 21: 431-9. PMID 19535234 DOI: 10.1016/j.coi.2009.05.011  0.96
2009 Liu Y, Sanoff HK, Cho H, Burd CE, Torrice C, Ibrahim JG, Thomas NE, Sharpless NE. Expression of p16(INK4a) in peripheral blood T-cells is a biomarker of human aging. Aging Cell. 8: 439-48. PMID 19485966 DOI: 10.1111/j.1474-9726.2009.00489.x  0.96
2009 Liu Y, Sanoff HK, Cho H, Burd CE, Torrice C, Mohlke KL, Ibrahim JG, Thomas NE, Sharpless NE. INK4/ARF transcript expression is associated with chromosome 9p21 variants linked to atherosclerosis. Plos One. 4: e5027. PMID 19343170 DOI: 10.1371/journal.pone.0005027  0.96
2009 Wingo SN, Gallardo TD, Akbay EA, Liang MC, Contreras CM, Boren T, Shimamura T, Miller DS, Sharpless NE, Bardeesy N, Kwiatkowski DJ, Schorge JO, Wong KK, Castrillon DH. Somatic LKB1 mutations promote cervical cancer progression. Plos One. 4: e5137. PMID 19340305 DOI: 10.1371/journal.pone.0005137  0.96
2009 Sharpless NE, Schatten G. Stem cell aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 64: 202-4. PMID 19228784 DOI: 10.1093/gerona/gln070  0.96
2009 Stirewalt DL, Choi YE, Sharpless NE, Pogosova-Agadjanyan EL, Cronk MR, Yukawa M, Larson EB, Wood BL, Appelbaum FR, Radich JP, Heimfeld S. Decreased IRF8 expression found in aging hematopoietic progenitor/stem cells. Leukemia. 23: 391-3. PMID 18596738 DOI: 10.1038/leu.2008.176  0.96
2009 Kim WY, Perera S, Zhou B, Carretero J, Yeh JJ, Heathcote SA, Jackson AL, Nikolinakos P, Ospina B, Naumov GN, Brandstetter KA, Weigman VJ, Zaghlul S, Hayes DN, Padera RF, ... ... Sharpless NE, et al. HIF2α cooperates with RAS to promote lung tumorigenesis in mice (Journal of Clinical Investigation (2009) 119, (2160-2170) doi:101172/JCI38443) Journal of Clinical Investigation. 119: 3182. DOI: 10.1172/JCI38443C1  0.96
2008 Hammond SM, Sharpless NE. HMGA2, microRNAs, and stem cell aging. Cell. 135: 1013-6. PMID 19070572 DOI: 10.1016/j.cell.2008.11.026  0.96
2008 Li W, Asokan A, Wu Z, Van Dyke T, DiPrimio N, Johnson JS, Govindaswamy L, Agbandje-McKenna M, Leichtle S, Redmond DE, McCown TJ, Petermann KB, Sharpless NE, Samulski RJ. Engineering and selection of shuffled AAV genomes: a new strategy for producing targeted biological nanoparticles. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1252-60. PMID 18500254 DOI: 10.1038/mt.2008.100  0.96
2008 Shah U, Sharpless NE, Hayes DN. LKB1 and lung cancer: more than the usual suspects. Cancer Research. 68: 3562-5. PMID 18483235 DOI: 10.1158/0008-5472.CAN-07-6620  0.96
2008 Min JN, Whaley RA, Sharpless NE, Lockyer P, Portbury AL, Patterson C. CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control. Molecular and Cellular Biology. 28: 4018-25. PMID 18411298 DOI: 10.1128/MCB.00296-08  0.96
2008 Kim WY, Sharpless NE. VHL inactivation: a new road to senescence. Cancer Cell. 13: 295-7. PMID 18394552 DOI: 10.1016/j.ccr.2008.03.012  0.96
2008 Kaufmann WK, Nevis KR, Qu P, Ibrahim JG, Zhou T, Zhou Y, Simpson DA, Helms-Deaton J, Cordeiro-Stone M, Moore DT, Thomas NE, Hao H, Liu Z, Shields JM, Scott GA, ... Sharpless NE, et al. Defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression. The Journal of Investigative Dermatology. 128: 175-87. PMID 17597816 DOI: 10.1038/sj.jid.5700935  0.96
2008 Sharpless NE. P16INK4a and stem cell ageing: A telomere-independent process? Telomeres and Telomerase in Ageing, Disease, and Cancer: Molecular Mechanisms of Adult Stem Cell Ageing. 181-202. DOI: 10.1007/978-3-540-73709-4_9  0.96
2007 Krishnamurthy J, Sharpless NE. Stem cells and the rate of living. Cell Stem Cell. 1: 9-11. PMID 18371325 DOI: 10.1016/j.stem.2007.05.004  0.96
2007 Petermann KB, Rozenberg GI, Zedek D, Groben P, McKinnon K, Buehler C, Kim WY, Shields JM, Penland S, Bear JE, Thomas NE, Serody JS, Sharpless NE. CD200 is induced by ERK and is a potential therapeutic target in melanoma. The Journal of Clinical Investigation. 117: 3922-9. PMID 18008004 DOI: 10.1172/JCI32163  0.96
2007 Sharpless NE, DePinho RA. How stem cells age and why this makes us grow old. Nature Reviews. Molecular Cell Biology. 8: 703-13. PMID 17717515 DOI: 10.1038/nrm2241  0.96
2007 Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera SA, Liang MC, Cai D, Naumov GN, Bao L, Contreras CM, ... ... Sharpless NE, et al. LKB1 modulates lung cancer differentiation and metastasis. Nature. 448: 807-10. PMID 17676035 DOI: 10.1038/nature06030  0.96
2007 Ha L, Ichikawa T, Anver M, Dickins R, Lowe S, Sharpless NE, Krimpenfort P, Depinho RA, Bennett DC, Sviderskaya EV, Merlino G. ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence. Proceedings of the National Academy of Sciences of the United States of America. 104: 10968-73. PMID 17576930 DOI: 10.1073/pnas.0611638104  0.96
2007 Ramsey MR, Krishnamurthy J, Pei XH, Torrice C, Lin W, Carrasco DR, Ligon KL, Xiong Y, Sharpless NE. Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues. Cancer Research. 67: 4732-41. PMID 17510401 DOI: 10.1158/0008-5472.CAN-06-3437  0.96
2007 Shields JM, Thomas NE, Cregger M, Berger AJ, Leslie M, Torrice C, Hao H, Penland S, Arbiser J, Scott G, Zhou T, Bar-Eli M, Bear JE, Der CJ, Kaufmann WK, ... ... Sharpless NE, et al. Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma. Cancer Research. 67: 1502-12. PMID 17308088 DOI: 10.1158/0008-5472.CAN-06-3311  0.96
2007 Penland SK, Keku TO, Torrice C, He X, Krishnamurthy J, Hoadley KA, Woosley JT, Thomas NE, Perou CM, Sandler RS, Sharpless NE. RNA expression analysis of formalin-fixed paraffin-embedded tumors. Laboratory Investigation; a Journal of Technical Methods and Pathology. 87: 383-91. PMID 17297435 DOI: 10.1038/labinvest.3700529  0.96
2007 Sharpless NE, DePinho RA. Cancer biology: gone but not forgotten. Nature. 445: 606-7. PMID 17251931 DOI: 10.1038/nature05567  0.96
2007 Bell JF, Sharpless NE. Telomeres, p21 and the cancer-aging hypothesis. Nature Genetics. 39: 11-2. PMID 17192782 DOI: 10.1038/ng0107-11  0.96
2006 Bardeesy N, Sharpless NE. RAS unplugged: negative feedback and oncogene-induced senescence. Cancer Cell. 10: 451-3. PMID 17157783 DOI: 10.1016/j.ccr.2006.11.015  0.96
2006 Ramsey MR, Sharpless NE. ROS as a tumour suppressor? Nature Cell Biology. 8: 1213-5. PMID 17077852 DOI: 10.1038/ncb1106-1213  0.96
2006 Kim WY, Sharpless NE. The regulation of INK4/ARF in cancer and aging. Cell. 127: 265-75. PMID 17055429 DOI: 10.1016/j.cell.2006.10.003  0.96
2006 Ji H, Sharpless NE, Wong KK. EGFR targeted therapy: view from biological standpoint. Cell Cycle (Georgetown, Tex.). 5: 2072-6. PMID 16969107  0.96
2006 Molofsky AV, Slutsky SG, Joseph NM, He S, Pardal R, Krishnamurthy J, Sharpless NE, Morrison SJ. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature. 443: 448-52. PMID 16957738 DOI: 10.1038/nature05091  0.96
2006 Krishnamurthy J, Ramsey MR, Ligon KL, Torrice C, Koh A, Bonner-Weir S, Sharpless NE. p16INK4a induces an age-dependent decline in islet regenerative potential. Nature. 443: 453-7. PMID 16957737 DOI: 10.1038/nature05092  0.96
2006 Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, Cheng T, DePinho RA, Sharpless NE, Scadden DT. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature. 443: 421-6. PMID 16957735 DOI: 10.1038/nature05159  0.96
2006 Sharpless NE, Depinho RA. The mighty mouse: genetically engineered mouse models in cancer drug development. Nature Reviews. Drug Discovery. 5: 741-54. PMID 16915232 DOI: 10.1038/nrd2110  0.96
2006 Ji H, Li D, Chen L, Shimamura T, Kobayashi S, McNamara K, Mahmood U, Mitchell A, Sun Y, Al-Hashem R, Chirieac LR, Padera R, Bronson RT, Kim W, Jänne PA, ... ... Sharpless NE, et al. The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies. Cancer Cell. 9: 485-95. PMID 16730237 DOI: 10.1016/j.ccr.2006.04.022  0.96
2006 Paliwal S, Pande S, Kovi RC, Sharpless NE, Bardeesy N, Grossman SR. Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis. Molecular and Cellular Biology. 26: 2360-72. PMID 16508011 DOI: 10.1128/MCB.26.6.2360-2372.2006  0.96
2006 Sharpless NE. Preparation and immortalization of primary murine cells Cell Biology, Four-Volume Set. 1: 223-228. DOI: 10.1016/B978-012164730-8/50029-0  0.96
2006 Sharpless NE, Chin L. The biology and genetics of melanoma From Melanocytes to Melanoma: the Progression to Malignancy. 265-290. DOI: 10.1007/978-1-59259-994-3_15  0.96
2005 Gibson SL, Boquoi A, Chen T, Sharpless NE, Brensinger C, Enders GH. p16(Ink4a) inhibits histologic progression and angiogenic signaling in min colon tumors. Cancer Biology & Therapy. 4: 1389-94. PMID 16322687  0.96
2005 Sharpless NE, DePinho RA. Cancer: crime and punishment. Nature. 436: 636-7. PMID 16079829 DOI: 10.1038/436636a  0.96
2005 Sharpless NE. INK4a/ARF: a multifunctional tumor suppressor locus. Mutation Research. 576: 22-38. PMID 15878778 DOI: 10.1016/j.mrfmmm.2004.08.021  0.96
2005 Rünger TM, Vergilis I, Sarkar P, DePinho RA, Sharpless NE. How disruption of cell cycle regulating genes might predispose to sun-induced skin cancer. Cell Cycle (Georgetown, Tex.). 4: 643-5. PMID 15846097  0.96
2004 Sharpless NE. Ink4a/Arf links senescence and aging. Experimental Gerontology. 39: 1751-9. PMID 15582292 DOI: 10.1016/j.exger.2004.06.025  0.96
2004 Sarkar-Agrawal P, Vergilis I, Sharpless NE, DePinho RA, Rünger TM. Impaired processing of DNA photoproducts and ultraviolet hypermutability with loss of p16INK4a or p19ARF. Journal of the National Cancer Institute. 96: 1790-3. PMID 15572761 DOI: 10.1093/jnci/djh307  0.96
2004 Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, Su L, Sharpless NE. Ink4a/Arf expression is a biomarker of aging. The Journal of Clinical Investigation. 114: 1299-307. PMID 15520862 DOI: 10.1172/JCI22475  0.96
2004 Turner JE, Alley JG, Sharpless NE. Medical problems in patients with malignancy: case 2. Wernicke's encephalopathy: an unusual acute neurologic complication of lymphoma and its therapy. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 22: 4020-2. PMID 15459227 DOI: 10.1200/JCO.2004.12.020  0.96
2004 Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE, Brenner DA, Jobin C. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-κB activation using a novel gene-targeted enhanced GFP reporter gene mouse Journal of Immunology. 173: 1561-1570. PMID 15265883  0.96
2004 Sachs Z, Sharpless NE, DePinho RA, Rosenberg N. p16(Ink4a) interferes with Abelson virus transformation by enhancing apoptosis. Journal of Virology. 78: 3304-11. PMID 15016851 DOI: 10.1128/JVI.78.7.3304-3311.2004  0.96
2004 Sharpless NE, Ramsey MR, Balasubramanian P, Castrillon DH, DePinho RA. The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis. Oncogene. 23: 379-85. PMID 14724566 DOI: 10.1038/sj.onc.1207074  0.96
2004 Sharpless NE, DePinho RA. Telomeres, stem cells, senescence, and cancer. The Journal of Clinical Investigation. 113: 160-8. PMID 14722605 DOI: 10.1172/JCI20761  0.96
2003 O'Hagan RC, Brennan CW, Strahs A, Zhang X, Kannan K, Donovan M, Cauwels C, Sharpless NE, Wong WH, Chin L. Array comparative genome hybridization for tumor classification and gene discovery in mouse models of malignant melanoma. Cancer Research. 63: 5352-6. PMID 14500367  0.96
2003 Sharpless NE. The persistence of senescence. Science of Aging Knowledge Environment : Sage Ke. 2003: PE24. PMID 12931012 DOI: 10.1126/sageke.2003.33.pe24  0.96
2003 Sharpless NE, Kannan K, Xu J, Bosenberg MW, Chin L. Both products of the mouse INK4a/ARF locus suppress melanoma formation in vivo Oncogene. 22: 5055-5059. PMID 12902988 DOI: 10.1038/sj.onc.1206809  0.96
2003 Sharpless NE, Chin L. The INK4α/ARF locus and melanoma Oncogene. 22: 3092-3098. PMID 12789286 DOI: 10.1038/sj.onc.1206461  0.96
2003 Kannan K, Sharpless NE, Xu J, O'Hagan RC, Bosenberg M, Chin L. Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model. Proceedings of the National Academy of Sciences of the United States of America. 100: 1221-5. PMID 12538879 DOI: 10.1073/pnas.0336397100  0.96
2002 Kulke MH, Demetri GD, Sharpless NE, Ryan DP, Shivdasani R, Clark JS, Spiegelman BM, Kim H, Mayer RJ, Fuchs CS. A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer. Cancer Journal (Sudbury, Mass.). 8: 395-9. PMID 12416897 DOI: 10.1097/00130404-200209000-00010  0.96
2002 Opitz OG, Harada H, Suliman Y, Rhoades B, Sharpless NE, Kent R, Kopelovich L, Nakagawa H, Rustgi AK. A mouse model of human oral-esophageal cancer. The Journal of Clinical Investigation. 110: 761-9. PMID 12235107 DOI: 10.1172/JCI15324  0.96
2002 Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, Loda M, Carrasco DR, DePinho RA. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature. 419: 162-7. PMID 12226664 DOI: 10.1038/nature01045  0.96
2002 Sharpless NE, DePinho RA. p53: good cop/bad cop. Cell. 110: 9-12. PMID 12150992 DOI: 10.1016/S0092-8674(02)00818-8  0.96
2002 Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell. 1: 269-77. PMID 12086863 DOI: 10.1016/S1535-6108(02)00046-6  0.96
2002 Artandi SE, Alson S, Tietze MK, Sharpless NE, Ye S, Greenberg RA, Castrillon DH, Horner JW, Weiler SR, Carrasco RD, DePinho RA. Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 8191-6. PMID 12034875 DOI: 10.1073/pnas.112515399  0.96
2002 Sharpless NE, Alson S, Chan S, Silver DP, Castrillon DH, DePinho RA. p16(INK4a) and p53 deficiency cooperate in tumorigenesis. Cancer Research. 62: 2761-5. PMID 12019151  0.96
2001 Sharpless NE, Ferguson DO, O'Hagan RC, Castrillon DH, Lee C, Farazi PA, Alson S, Fleming J, Morton CC, Frank K, Chin L, Alt FW, DePinho RA. Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions. Molecular Cell. 8: 1187-96. PMID 11779495 DOI: 10.1016/S1097-2765(01)00425-7  0.96
2001 Sharpless NE, Bardeesy N, Lee KH, Carrasco D, Castrillon DH, Aguirre AJ, Wu EA, Horner JW, DePinho RA. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature. 413: 86-91. PMID 11544531 DOI: 10.1038/35092592  0.96
2001 Bardeesy N, Sharpless NE, DePinho RA, Merlino G. The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model. Seminars in Cancer Biology. 11: 201-18. PMID 11407945 DOI: 10.1006/scbi.2000.0371  0.96
2001 Martelli F, Hamilton T, Silver DP, Sharpless NE, Bardeesy N, Rokas M, DePinho RA, Livingston DM, Grossman SR. p19ARF targets certain E2F species for degradation. Proceedings of the National Academy of Sciences of the United States of America. 98: 4455-60. PMID 11274364 DOI: 10.1073/pnas.081061398  0.96
2000 Ferguson DO, Sekiguchi JM, Frank KM, Gao Y, Sharpless NE, Gu Y, Manis J, DePinho RA, Alt FW. The interplay between nonhomologous end-joining and cell cycle checkpoint factors in development, genomic stability, and tumorigenesis. Cold Spring Harbor Symposia On Quantitative Biology. 65: 395-403. PMID 12760055  0.96
2000 Frank KM, Sharpless NE, Gao Y, Sekiguchi JM, Ferguson DO, Zhu C, Manis JP, Horner J, DePinho RA, Alt FW. DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Molecular Cell. 5: 993-1002. PMID 10911993  0.96
1999 Sharpless NE, DePinho RA. The INK4A/ARF locus and its two gene products. Current Opinion in Genetics & Development. 9: 22-30. PMID 10072356 DOI: 10.1016/S0959-437X(99)80004-5  0.96
1998 Penson RT, Shannon KE, Sharpless NE, Seiden MV. Ovarian cancer: An update on genetics and therapy Comprehensive Therapy. 24: 477-487. PMID 9801846  0.96
1998 Sharpless NE, Seiden MV. Advanced ovarian cancer: Recent progress and current challenges Contemporary Ob-Gyn. 43: 123-137.  0.96
1997 Sharpless NE, Seiden MV. Managing advanced ovarian cancer Im - Internal Medicine. 18: 46-55.  0.96
1992 Sharpless NE, O'Brien WA, Verdin E, Kufta CV, Chen ISY, Dubois-Dalcq M. Human immunodeficiency virus type 1 tropism for brain microglial cells is determined by a region of the env glycoprotein that also controls macrophage tropism Journal of Virology. 66: 2588-2593. PMID 1548785  0.96
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