Ralf Langen - Publications

Biochemistry and Molecular Biology University of Southern California, Los Angeles, CA, United States 
Molecular Biology

102 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Vasquez-Montes V, Vargas-Uribe M, Pandey NK, Rodnin MV, Langen R, Ladokhin AS. Lipid-modulation of membrane insertion and refolding of the apoptotic inhibitor Bcl-xL. Biochimica Et Biophysica Acta. Proteins and Proteomics. PMID 31004798 DOI: 10.1016/j.bbapap.2019.04.006  0.4
2018 Ko J, Isas JM, Sabbaugh A, Yoo JH, Pandey NK, Chongtham A, Ladinsky M, Wu WL, Rohweder H, Weiss A, Macdonald D, Munoz-Sanjuan I, Langen R, Patterson PH, Khoshnan A. Identification of distinct conformations associated with monomers and fibril assemblies of mutant huntingtin. Human Molecular Genetics. PMID 29912367 DOI: 10.1093/hmg/ddy141  0.6
2017 Pandey NK, Isas JM, Rawat A, Lee RV, Langen J, Pandey P, Langen R. The 17-residue-long N terminus in huntingtin controls step-wise aggregation in solution and on membranes via different mechanisms. The Journal of Biological Chemistry. PMID 29282287 DOI: 10.1074/jbc.M117.813667  0.6
2017 Okada AK, Teranishi K, Lobo F, Isas JM, Xiao J, Yen K, Cohen P, Langen R. The Mitochondrial-Derived Peptides, HumaninS14G and Small Humanin-like Peptide 2, Exhibit Chaperone-like Activity. Scientific Reports. 7: 7802. PMID 28798389 DOI: 10.1038/s41598-017-08372-5  0.6
2017 Melo AA, Hegde BG, Shah C, Larsson E, Isas JM, Kunz S, Lundmark R, Langen R, Daumke O. Structural insights into the activation mechanism of dynamin-like EHD ATPases. Proceedings of the National Academy of Sciences of the United States of America. PMID 28228524 DOI: 10.1073/pnas.1614075114  0.64
2016 Fisette O, Päslack C, Barnes R, Isas JM, Langen R, Heyden M, Han S, Schäfer LV. Hydration dynamics of a peripheral membrane protein. Journal of the American Chemical Society. PMID 27548572 DOI: 10.1021/jacs.6b07005  0.6
2016 Okada AK, Teranishi K, Isas JM, Bedrood S, Chow RH, Langen R. Diabetic Risk Factors Promote Islet Amyloid Polypeptide Misfolding by a Common, Membrane-mediated Mechanism. Scientific Reports. 6: 31094. PMID 27531121 DOI: 10.1038/srep31094  0.76
2015 Dearborn AD, Wall JS, Cheng N, Heymann JB, Kajava AV, Varkey J, Langen R, Steven AC. α-Synuclein Amyloid Fibrils with Two Entwined, Asymmetrically Associated, Protofibrils. The Journal of Biological Chemistry. PMID 26644467 DOI: 10.1074/jbc.M115.698787  0.48
2015 Beasley KN, Sutch BT, Hatmal MM, Langen R, Qin PZ, Haworth IS. Computer Modeling of Spin Labels: NASNOX, PRONOX, and ALLNOX. Methods in Enzymology. 563: 569-93. PMID 26478499 DOI: 10.1016/bs.mie.2015.07.021  0.64
2015 Ambroso MR, Haworth IS, Langen R. Structural Characterization of Membrane-Curving Proteins: Site-Directed Spin Labeling, EPR, and Computational Refinement. Methods in Enzymology. 564: 259-88. PMID 26477254 DOI: 10.1016/bs.mie.2015.07.002  0.76
2015 Kegulian NC, Sankhagowit S, Apostolidou M, Jayasinghe SA, Malmstadt N, Butler PC, Langen R. Membrane Curvature-Sensing and -Inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption. The Journal of Biological Chemistry. PMID 26283787 DOI: 10.1074/jbc.M115.659797  0.76
2015 Isas JM, Langen R, Siemer AB. Solid-State Nuclear Magnetic Resonance on the Static and Dynamic Domains of Huntingtin Exon-1 Fibrils. Biochemistry. 54: 3942-9. PMID 26020223 DOI: 10.1021/acs.biochem.5b00281  0.76
2015 Darrow MC, Sergeeva OA, Isas JM, Galaz-Montoya J, King JA, Langen R, Schmid MF, Chiu W. Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by Synthetic Chaperonin-like CCT5 Complex Explained by Cryo-electron Tomography. The Journal of Biological Chemistry. PMID 25995452 DOI: 10.1074/jbc.M115.655373  0.6
2015 Isas JM, Ambroso MR, Hegde PB, Langen J, Langen R. Tubulation by amphiphysin requires concentration-dependent switching from wedging to scaffolding. Structure (London, England : 1993). 23: 873-81. PMID 25865245 DOI: 10.1016/j.str.2015.02.014  0.76
2014 Fodale V, Kegulian NC, Verani M, Cariulo C, Azzollini L, Petricca L, Daldin M, Boggio R, Padova A, Kuhn R, Pacifici R, Macdonald D, Schoenfeld RC, Park H, Isas JM, ... Langen R, et al. Polyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopy. Plos One. 9: e112262. PMID 25464275 DOI: 10.1371/journal.pone.0112262  0.76
2014 Lai Y, Kim S, Varkey J, Lou X, Song JK, Diao J, Langen R, Shin YK. Nonaggregated α-synuclein influences SNARE-dependent vesicle docking via membrane binding. Biochemistry. 53: 3889-96. PMID 24884175 DOI: 10.1021/bi5002536  0.76
2014 Ambroso MR, Hegde BG, Langen R. Endophilin A1 induces different membrane shapes using a conformational switch that is regulated by phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 111: 6982-7. PMID 24778241 DOI: 10.1073/pnas.1402233111  0.76
2014 Shah C, Hegde BG, Morén B, Behrmann E, Mielke T, Moenke G, Spahn CM, Lundmark R, Daumke O, Langen R. Structural insights into membrane interaction and caveolar targeting of dynamin-like EHD2. Structure (London, England : 1993). 22: 409-20. PMID 24508342 DOI: 10.1016/j.str.2013.12.015  0.76
2013 Cheng CY, Varkey J, Ambroso MR, Langen R, Han S. Hydration dynamics as an intrinsic ruler for refining protein structure at lipid membrane interfaces. Proceedings of the National Academy of Sciences of the United States of America. 110: 16838-43. PMID 24082088 DOI: 10.1073/pnas.1307678110  0.76
2013 Moaven H, Koike Y, Jao CC, Gurevich VV, Langen R, Chen J. Visual arrestin interaction with clathrin adaptor AP-2 regulates photoreceptor survival in the vertebrate retina. Proceedings of the National Academy of Sciences of the United States of America. 110: 9463-8. PMID 23690606 DOI: 10.1073/pnas.1301126110  0.76
2013 Varkey J, Mizuno N, Hegde BG, Cheng N, Steven AC, Langen R. α-Synuclein oligomers with broken helical conformation form lipoprotein nanoparticles. The Journal of Biological Chemistry. 288: 17620-30. PMID 23609437 DOI: 10.1074/jbc.M113.476697  0.76
2013 Costes S, Langen R, Gurlo T, Matveyenko AV, Butler PC. β-Cell failure in type 2 diabetes: a case of asking too much of too few? Diabetes. 62: 327-35. PMID 23349537 DOI: 10.2337/db12-1326  0.76
2012 Ladiwala AR, Bhattacharya M, Perchiacca JM, Cao P, Raleigh DP, Abedini A, Schmidt AM, Varkey J, Langen R, Tessier PM. Rational design of potent domain antibody inhibitors of amyloid fibril assembly. Proceedings of the National Academy of Sciences of the United States of America. 109: 19965-70. PMID 23161913 DOI: 10.1073/pnas.1208797109  0.76
2012 Li Y, Hatmal MM, Langen R, Haworth IS. Idealized models of protofilaments of human islet amyloid polypeptide. Journal of Chemical Information and Modeling. 52: 2983-91. PMID 23116372 DOI: 10.1021/ci300300e  0.76
2012 Woodham AW, Da Silva DM, Skeate JG, Raff AB, Ambroso MR, Brand HE, Isas JM, Langen R, Kast WM. The S100A10 subunit of the annexin A2 heterotetramer facilitates L2-mediated human papillomavirus infection. Plos One. 7: e43519. PMID 22927980 DOI: 10.1371/journal.pone.0043519  0.76
2012 Lai CL, Jao CC, Lyman E, Gallop JL, Peter BJ, McMahon HT, Langen R, Voth GA. Membrane binding and self-association of the epsin N-terminal homology domain. Journal of Molecular Biology. 423: 800-17. PMID 22922484 DOI: 10.1016/j.jmb.2012.08.010  0.76
2012 Bugg CW, Isas JM, Fischer T, Patterson PH, Langen R. Structural features and domain organization of huntingtin fibrils. The Journal of Biological Chemistry. 287: 31739-46. PMID 22801429 DOI: 10.1074/jbc.M112.353839  0.76
2012 Mizuno N, Varkey J, Kegulian NC, Hegde BG, Cheng N, Langen R, Steven AC. Remodeling of lipid vesicles into cylindrical micelles by α-synuclein in an extended α-helical conformation. The Journal of Biological Chemistry. 287: 29301-11. PMID 22767608 DOI: 10.1074/jbc.M112.365817  0.76
2012 Ruggiero L, Connor MP, Chen J, Langen R, Finnemann SC. Diurnal, localized exposure of phosphatidylserine by rod outer segment tips in wild-type but not Itgb5-/- or Mfge8-/- mouse retina. Proceedings of the National Academy of Sciences of the United States of America. 109: 8145-8. PMID 22566632 DOI: 10.1073/pnas.1121101109  0.76
2012 Meier F, Abeywardana T, Dhall A, Marotta NP, Varkey J, Langen R, Chatterjee C, Pratt MR. Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation. Journal of the American Chemical Society. 134: 5468-71. PMID 22404520 DOI: 10.1021/ja300094r  0.76
2012 Krishnamani V, Hegde BG, Langen R, Lanyi JK. Secondary and tertiary structure of bacteriorhodopsin in the SDS denatured state. Biochemistry. 51: 1051-60. PMID 22242919 DOI: 10.1021/bi201769z  0.76
2012 Bedrood S, Li Y, Isas JM, Hegde BG, Baxa U, Haworth IS, Langen R. Fibril structure of human islet amyloid polypeptide. The Journal of Biological Chemistry. 287: 5235-41. PMID 22187437 DOI: 10.1074/jbc.M111.327817  0.76
2012 Hatmal MM, Li Y, Hegde BG, Hegde PB, Jao CC, Langen R, Haworth IS. Computer modeling of nitroxide spin labels on proteins. Biopolymers. 97: 35-44. PMID 21792846 DOI: 10.1002/bip.21699  0.76
2011 Jensen MB, Bhatia VK, Jao CC, Rasmussen JE, Pedersen SL, Jensen KJ, Langen R, Stamou D. Membrane curvature sensing by amphipathic helices: a single liposome study using α-synuclein and annexin B12. The Journal of Biological Chemistry. 286: 42603-14. PMID 21953452 DOI: 10.1074/jbc.M111.271130  0.76
2011 Richard JP, Leikina E, Langen R, Henne WM, Popova M, Balla T, McMahon HT, Kozlov MM, Chernomordik LV. Intracellular curvature-generating proteins in cell-to-cell fusion. The Biochemical Journal. 440: 185-93. PMID 21895608 DOI: 10.1042/BJ20111243  0.76
2011 Zhang QC, Yeh TL, Leyva A, Frank LG, Miller J, Kim YE, Langen R, Finkbeiner S, Amzel ML, Ross CA, Poirier MA. A compact beta model of huntingtin toxicity. The Journal of Biological Chemistry. 286: 8188-96. PMID 21209075 DOI: 10.1074/jbc.M110.192013  0.76
2010 Heinrich MC, Capraro BR, Tian A, Isas JM, Langen R, Baumgart T. Quantifying Membrane Curvature Generation of Drosophila Amphiphysin N-BAR Domains. The Journal of Physical Chemistry Letters. 1: 3401-3406. PMID 23772271 DOI: 10.1021/jz101403q  0.76
2010 Daval M, Bedrood S, Gurlo T, Huang CJ, Costes S, Butler PC, Langen R. The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 17: 118-28. PMID 21067307 DOI: 10.3109/13506129.2010.530008  0.76
2010 Varkey J, Isas JM, Mizuno N, Jensen MB, Bhatia VK, Jao CC, Petrlova J, Voss JC, Stamou DG, Steven AC, Langen R. Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins. The Journal of Biological Chemistry. 285: 32486-93. PMID 20693280 DOI: 10.1074/jbc.M110.139576  0.76
2010 Kim YE, Chen J, Langen R, Chan JR. Monitoring apoptosis and neuronal degeneration by real-time detection of phosphatidylserine externalization using a polarity-sensitive indicator of viability and apoptosis. Nature Protocols. 5: 1396-405. PMID 20671723 DOI: 10.1038/nprot.2010.101  0.76
2010 Ritzel RA, Jayasinghe S, Hansen JB, Sturis J, Langen R, Butler PC. Beta-cell selective K(ATP)-channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity. Regulatory Peptides. 165: 158-62. PMID 20619299 DOI: 10.1016/j.regpep.2010.06.009  0.76
2010 Rao JN, Jao CC, Hegde BG, Langen R, Ulmer TS. A combinatorial NMR and EPR approach for evaluating the structural ensemble of partially folded proteins. Journal of the American Chemical Society. 132: 8657-68. PMID 20524659 DOI: 10.1021/ja100646t  0.76
2010 Mizuno N, Jao CC, Langen R, Steven AC. Multiple modes of endophilin-mediated conversion of lipid vesicles into coated tubes: implications for synaptic endocytosis. The Journal of Biological Chemistry. 285: 23351-8. PMID 20484046 DOI: 10.1074/jbc.M110.143776  0.76
2010 Jao CC, Hegde BG, Gallop JL, Hegde PB, McMahon HT, Haworth IS, Langen R. Roles of amphipathic helices and the bin/amphiphysin/rvs (BAR) domain of endophilin in membrane curvature generation. The Journal of Biological Chemistry. 285: 20164-70. PMID 20418375 DOI: 10.1074/jbc.M110.127811  0.76
2010 Ladner CL, Chen M, Smith DP, Platt GW, Radford SE, Langen R. Stacked sets of parallel, in-register beta-strands of beta2-microglobulin in amyloid fibrils revealed by site-directed spin labeling and chemical labeling. The Journal of Biological Chemistry. 285: 17137-47. PMID 20335170 DOI: 10.1074/jbc.M110.117234  0.76
2010 Wu JW, Breydo L, Isas JM, Lee J, Kuznetsov YG, Langen R, Glabe C. Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formation. The Journal of Biological Chemistry. 285: 6071-9. PMID 20018889 DOI: 10.1074/jbc.M109.069542  0.76
2010 Kim YE, Chen J, Chan JR, Langen R. Engineering a polarity-sensitive biosensor for time-lapse imaging of apoptotic processes and degeneration. Nature Methods. 7: 67-73. PMID 19966809 DOI: 10.1038/nmeth.1405  0.76
2010 Isas JM, Luibl V, Johnson LV, Kayed R, Wetzel R, Glabe CG, Langen R, Chen J. Soluble and mature amyloid fibrils in drusen deposits. Investigative Ophthalmology & Visual Science. 51: 1304-10. PMID 19892876 DOI: 10.1167/iovs.09-4207  0.76
2009 Bedrood S, Jayasinghe S, Sieburth D, Chen M, Erbel S, Butler PC, Langen R, Ritzel RA. Annexin A5 directly interacts with amyloidogenic proteins and reduces their toxicity. Biochemistry. 48: 10568-76. PMID 19810772 DOI: 10.1021/bi900608m  0.76
2008 Margittai M, Langen R. Fibrils with parallel in-register structure constitute a major class of amyloid fibrils: molecular insights from electron paramagnetic resonance spectroscopy. Quarterly Reviews of Biophysics. 41: 265-97. PMID 19079806 DOI: 10.1017/S0033583508004733  0.76
2008 Jao CC, Hegde BG, Chen J, Haworth IS, Langen R. Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement. Proceedings of the National Academy of Sciences of the United States of America. 105: 19666-71. PMID 19066219 DOI: 10.1073/pnas.0807826105  0.76
2008 Shin TM, Isas JM, Hsieh CL, Kayed R, Glabe CG, Langen R, Chen J. Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin. Molecular Neurodegeneration. 3: 16. PMID 18939994 DOI: 10.1186/1750-1326-3-16  0.76
2008 Apostolidou M, Jayasinghe SA, Langen R. Structure of alpha-helical membrane-bound human islet amyloid polypeptide and its implications for membrane-mediated misfolding. The Journal of Biological Chemistry. 283: 17205-10. PMID 18442979 DOI: 10.1074/jbc.M801383200  0.76
2007 Chen M, Margittai M, Chen J, Langen R. Investigation of alpha-synuclein fibril structure by site-directed spin labeling. The Journal of Biological Chemistry. 282: 24970-9. PMID 17573347 DOI: 10.1074/jbc.M700368200  0.76
2007 Henne WM, Kent HM, Ford MG, Hegde BG, Daumke O, Butler PJ, Mittal R, Langen R, Evans PR, McMahon HT. Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature. Structure (London, England : 1993). 15: 839-52. PMID 17540576 DOI: 10.1016/j.str.2007.05.002  0.76
2007 Jayasinghe SA, Langen R. Membrane interaction of islet amyloid polypeptide. Biochimica Et Biophysica Acta. 1768: 2002-9. PMID 17349968 DOI: 10.1016/j.bbamem.2007.01.022  0.76
2007 Fischer T, Lu L, Haigler HT, Langen R. Annexin B12 is a sensor of membrane curvature and undergoes major curvature-dependent structural changes. The Journal of Biological Chemistry. 282: 9996-10004. PMID 17267400 DOI: 10.1074/jbc.M611180200  0.76
2006 Margittai M, Langen R. Spin labeling analysis of amyloids and other protein aggregates. Methods in Enzymology. 413: 122-39. PMID 17046394 DOI: 10.1016/S0076-6879(06)13007-4  0.76
2006 Margittai M, Langen R. Side chain-dependent stacking modulates tau filament structure. The Journal of Biological Chemistry. 281: 37820-7. PMID 17023423 DOI: 10.1074/jbc.M605336200  0.76
2006 Meier JJ, Kayed R, Lin CY, Gurlo T, Haataja L, Jayasinghe S, Langen R, Glabe CG, Butler PC. Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP. American Journal of Physiology. Endocrinology and Metabolism. 291: E1317-24. PMID 16849627 DOI: 10.1152/ajpendo.00082.2006  0.76
2006 Gallop JL, Jao CC, Kent HM, Butler PJ, Evans PR, Langen R, McMahon HT. Mechanism of endophilin N-BAR domain-mediated membrane curvature. The Embo Journal. 25: 2898-910. PMID 16763559 DOI: 10.1038/sj.emboj.7601174  0.76
2006 Luibl V, Isas JM, Kayed R, Glabe CG, Langen R, Chen J. Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers. The Journal of Clinical Investigation. 116: 378-85. PMID 16453022 DOI: 10.1172/JCI25843  0.76
2006 Hegde BG, Isas JM, Zampighi G, Haigler HT, Langen R. A novel calcium-independent peripheral membrane-bound form of annexin B12. Biochemistry. 45: 934-42. PMID 16411769 DOI: 10.1021/bi052143+  0.76
2005 Isas JM, Kim YE, Jao CC, Hegde PB, Haigler HT, Langen R. Calcium- and membrane-induced changes in the structure and dynamics of three helical hairpins in annexin B12. Biochemistry. 44: 16435-44. PMID 16342936 DOI: 10.1021/bi051751m  0.76
2005 Shi GW, Chen J, Concepcion F, Motamedchaboki K, Marjoram P, Langen R, Chen J. Light causes phosphorylation of nonactivated visual pigments in intact mouse rod photoreceptor cells. The Journal of Biological Chemistry. 280: 41184-91. PMID 16219764 DOI: 10.1074/jbc.M506935200  0.76
2005 Jayasinghe SA, Langen R. Lipid membranes modulate the structure of islet amyloid polypeptide. Biochemistry. 44: 12113-9. PMID 16142909 DOI: 10.1021/bi050840w  0.76
2005 Kim YE, Isas JM, Haigler HT, Langen R. A helical hairpin region of soluble annexin B12 refolds and forms a continuous transmembrane helix at mildly acidic pH. The Journal of Biological Chemistry. 280: 32398-404. PMID 15975928 DOI: 10.1074/jbc.M505017200  0.76
2005 Raghavan SC, Chastain P, Lee JS, Hegde BG, Houston S, Langen R, Hsieh CL, Haworth IS, Lieber MR. Evidence for a triplex DNA conformation at the bcl-2 major breakpoint region of the t(14;18) translocation. The Journal of Biological Chemistry. 280: 22749-60. PMID 15840562 DOI: 10.1074/jbc.M502952200  0.76
2005 Patel DR, Isas JM, Ladokhin AS, Jao CC, Kim YE, Kirsch T, Langen R, Haigler HT. The conserved core domains of annexins A1, A2, A5, and B12 can be divided into two groups with different Ca2+-dependent membrane-binding properties. Biochemistry. 44: 2833-44. PMID 15723527 DOI: 10.1021/bi047642+  0.76
2004 Lee JC, Langen R, Hummel PA, Gray HB, Winkler JR. Alpha-synuclein structures from fluorescence energy-transfer kinetics: implications for the role of the protein in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 16466-71. PMID 15536128 DOI: 10.1073/pnas.0407307101  0.76
2004 Jayasinghe SA, Langen R. Identifying structural features of fibrillar islet amyloid polypeptide using site-directed spin labeling. The Journal of Biological Chemistry. 279: 48420-5. PMID 15358791 DOI: 10.1074/jbc.M406853200  0.76
2004 Raghavan SC, Houston S, Hegde BG, Langen R, Haworth IS, Lieber MR. Stability and strand asymmetry in the non-B DNA structure at the bcl-2 major breakpoint region. The Journal of Biological Chemistry. 279: 46213-25. PMID 15328356 DOI: 10.1074/jbc.M406280200  0.76
2004 Margittai M, Langen R. Template-assisted filament growth by parallel stacking of tau. Proceedings of the National Academy of Sciences of the United States of America. 101: 10278-83. PMID 15240881 DOI: 10.1073/pnas.0401911101  0.76
2004 Jao CC, Der-Sarkissian A, Chen J, Langen R. Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling. Proceedings of the National Academy of Sciences of the United States of America. 101: 8331-6. PMID 15155902 DOI: 10.1073/pnas.0400553101  0.76
2004 Isas JM, Langen R, Hubbell WL, Haigler HT. Structure and dynamics of a helical hairpin that mediates calcium-dependent membrane binding of annexin B12. The Journal of Biological Chemistry. 279: 32492-8. PMID 15143059 DOI: 10.1074/jbc.M402568200  0.76
2003 Der-Sarkissian A, Jao CC, Chen J, Langen R. Structural organization of alpha-synuclein fibrils studied by site-directed spin labeling. The Journal of Biological Chemistry. 278: 37530-5. PMID 12815044 DOI: 10.1074/jbc.M305266200  0.76
2003 Isas JM, Patel DR, Jao C, Jayasinghe S, Cartailler JP, Haigler HT, Langen R. Global structural changes in annexin 12. The roles of phospholipid, Ca2+, and pH. The Journal of Biological Chemistry. 278: 30227-34. PMID 12756261 DOI: 10.1074/jbc.M301228200  0.76
2003 Margittai M, Fasshauer D, Jahn R, Langen R. The Habc domain and the SNARE core complex are connected by a highly flexible linker. Biochemistry. 42: 4009-14. PMID 12680753 DOI: 10.1021/bi027437z  0.76
2002 Török M, Milton S, Kayed R, Wu P, McIntire T, Glabe CG, Langen R. Structural and dynamic features of Alzheimer's Abeta peptide in amyloid fibrils studied by site-directed spin labeling. The Journal of Biological Chemistry. 277: 40810-5. PMID 12181315 DOI: 10.1074/jbc.M205659200  0.76
2002 Isas JM, Langen R, Haigler HT, Hubbell WL. Structure and dynamics of a helical hairpin and loop region in annexin 12: a site-directed spin labeling study. Biochemistry. 41: 1464-73. PMID 11814339 DOI: 10.1021/bi011856z  0.76
2002 Pabst S, Margittai M, Vainius D, Langen R, Jahn R, Fasshauer D. Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis. The Journal of Biological Chemistry. 277: 7838-48. PMID 11751907 DOI: 10.1074/jbc.M109507200  0.76
2001 Patel DR, Jao CC, Mailliard WS, Isas JM, Langen R, Haigler HT. Calcium-dependent binding of annexin 12 to phospholipid bilayers: stoichiometry and implications. Biochemistry. 40: 7054-60. PMID 11401549 DOI: 10.1021/bi010345+  0.76
2001 Margittai M, Fasshauer D, Pabst S, Jahn R, Langen R. Homo- and heterooligomeric SNARE complexes studied by site-directed spin labeling. The Journal of Biological Chemistry. 276: 13169-77. PMID 11278719 DOI: 10.1074/jbc.M010653200  0.76
2000 Langen R, Oh KJ, Cascio D, Hubbell WL. Crystal structures of spin labeled T4 lysozyme mutants: implications for the interpretation of EPR spectra in terms of structure. Biochemistry. 39: 8396-405. PMID 10913245 DOI: 10.1021/bi000604f  0.76
2000 Isas JM, Cartailler JP, Sokolov Y, Patel DR, Langen R, Luecke H, Hall JE, Haigler HT. Annexins V and XII insert into bilayers at mildly acidic pH and form ion channels. Biochemistry. 39: 3015-22. PMID 10715122 DOI: 10.1021/bi9922401  0.76
1999 MacKenzie CR, Langen R, Takikawa O, Däubener W. Inhibition of indoleamine 2,3-dioxygenase in human macrophages inhibits interferon-γ-induced bacteriostasis but does not abrogate toxoplasmastasis European Journal of Immunology. 29: 3254-3261. PMID 10540337 DOI: 10.1002/(SICI)1521-4141(199910)29:10<3254::AID-IMMU3254>3.0.CO;2-0  0.76
1999 Langen R, Cai K, Altenbach C, Khorana HG, Hubbell WL. Structural features of the C-terminal domain of bovine rhodopsin: a site-directed spin-labeling study. Biochemistry. 38: 7918-24. PMID 10387033 DOI: 10.1021/bi990010g  0.76
1998 Langen R, Isas JM, Hubbell WL, Haigler HT. A transmembrane form of annexin XII detected by site-directed spin labeling. Proceedings of the National Academy of Sciences of the United States of America. 95: 14060-5. PMID 9826653 DOI: 10.1073/pnas.95.24.14060  0.76
1998 Hubbell WL, Gross A, Langen R, Lietzow MA. Recent advances in site-directed spin labeling of proteins. Current Opinion in Structural Biology. 8: 649-56. PMID 9818271 DOI: 10.1016/S0959-440X(98)80158-9  0.76
1998 Langen R, Isas JM, Luecke H, Haigler HT, Hubbell WL. Membrane-mediated assembly of annexins studied by site-directed spin labeling. The Journal of Biological Chemistry. 273: 22453-7. PMID 9712869 DOI: 10.1074/jbc.273.35.22453  0.76
1997 Cai K, Langen R, Hubbell WL, Khorana HG. Structure and function in rhodopsin: topology of the C-terminal polypeptide chain in relation to the cytoplasmic loops. Proceedings of the National Academy of Sciences of the United States of America. 94: 14267-72. PMID 9405601 DOI: 10.1073/pnas.94.26.14267  0.76
1997 Kalinski T, Jaquet K, Langen R, Wang L, Gabbert HE, Gerharz CD. An optimized electroporation protocol for transfection of sensitive cell lines using basic laboratory equipment Biotechnology Techniques. 11: 717-722.  0.76
1996 Muegge I, Schweins T, Langen R, Warshel A. Electrostatic control of GTP and GDP binding in the oncoprotein p21ras. Structure (London, England : 1993). 4: 475-89. PMID 8740369  0.76
1996 Langen R, Colón JL, Casimiro DR, Karpishin TB, Winkler JR, Gray HB. Electron tunneling in proteins: Role of the intervening medium Journal of Biological Inorganic Chemistry. 1: 221-225. DOI: 10.1007/s007750050046  0.76
1996 Slutter CE, Langen R, Sanders D, Lawrence SM, Wittung P, Di Bilio AJ, Hill MG, Fee JA, Richards JH, Winkler JR, Malmström BG. Electron-transfer studies with the CuA domain of Thermus thermophilus cytochrome ba3 Inorganica Chimica Acta. 243: 141-145.  0.76
1995 Regan JJ, Di Bilio AJ, Langen R, Skov LK, Winkler JR, Gray HB, Onuchic JN. Electron tunneling in azurin: the coupling across a beta-sheet. Chemistry & Biology. 2: 489-96. PMID 9383451 DOI: 10.1016/1074-5521(95)90266-X  0.76
1995 Bjerrum MJ, Casimiro DR, Chang IJ, Di Bilio AJ, Gray HB, Hill MG, Langen R, Mines GA, Skov LK, Winkler JR. Electron transfer in ruthenium-modified proteins. Journal of Bioenergetics and Biomembranes. 27: 295-302. PMID 8847343 DOI: 10.1007/BF02110099  0.76
1995 Langen R, Chang IJ, Germanas JP, Richards JH, Winkler JR, Gray HB. Electron tunneling in proteins: coupling through a beta strand. Science (New York, N.Y.). 268: 1733-5. PMID 7792598  0.76
1994 Schweins T, Langen R, Warshel A. Why have mutagenesis studies not located the general base in ras p21. Nature Structural Biology. 1: 476-84. PMID 7664067 DOI: 10.1038/nsb0794-476  0.76
1992 Langen R, Jensen GM, Jacob U, Stephens PJ, Warshel A. Protein control of iron-sulfur cluster redox potentials. The Journal of Biological Chemistry. 267: 25625-7. PMID 1464583  0.76
1992 Langen R, Schweins T, Warshel A. On the mechanism of guanosine triphosphate hydrolysis in ras p21 proteins. Biochemistry. 31: 8691-6. PMID 1390653 DOI: 10.1021/bi00152a002  0.76
1992 Langen R, Brayer GD, Berghuis AM, McLendon G, Sherman F, Warshel A. Effect of the Asn52----Ile mutation on the redox potential of yeast cytochrome c. Theory and experiment. Journal of Molecular Biology. 224: 589-600. PMID 1314900 DOI: 10.1016/0022-2836(92)90546-V  0.76
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