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Channing J. Der - Publications

Affiliations: 
Genetics & Molecular Biology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Molecular Biology, Cell Biology
Website:
https://unclineberger.org/people/profiles/channing-j.-der

271 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Ozkan-Dagliyan I, Diehl JN, George SD, Schaefer A, Papke B, Klotz-Noack K, Waters AM, Goodwin CM, Gautam P, Pierobon M, Peng S, Gilbert TSK, Lin KH, Dagliyan O, Wennerberg K, ... ... Der CJ, et al. Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers. Cell Reports. 31: 107764. PMID 32553168 DOI: 10.1016/j.celrep.2020.107764  0.44
2020 Bryant KL, Stalnecker CA, Zeitouni D, Klomp JE, Peng S, Tikunov AP, Gunda V, Pierobon M, Waters AM, George SD, Tomar G, Papke B, Hobbs GA, Yan L, Hayes TK, ... ... Der CJ, et al. Author Correction: Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer. Nature Medicine. PMID 32483362 DOI: 10.1038/s41591-020-0947-8  0.44
2019 Zhang H, Schaefer A, Wang Y, Hodge RG, Blake DR, Diehl JN, Papageorge AG, Stachler MD, Liao J, Zhou J, Wu Z, Akarca FG, de Klerk LK, Derks S, Pierobon M, ... ... Der CJ, et al. Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer. Cancer Discovery. PMID 31771969 DOI: 10.1158/2159-8290.CD-19-0811  0.44
2019 Hobbs GA, Baker NM, Miermont AM, Thurman RD, Pierobon M, Tran TH, Anderson AO, Waters AM, Diehl JN, Papke B, Hodge RG, Klomp JE, Goodwin CM, DeLiberty JM, Wang J, ... ... Der CJ, et al. Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer. Cancer Discovery. PMID 31649109 DOI: 10.1158/2159-8290.CD-19-1006  0.44
2019 Blake DR, Vaseva AV, Hodge RG, Kline MP, Gilbert TSK, Tyagi V, Huang D, Whiten GC, Larson JE, Wang X, Pearce KH, Herring LE, Graves LM, Frye SV, Emanuele MJ, ... ... Der CJ, et al. Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer. Science Signaling. 12. PMID 31311847 DOI: 10.1126/scisignal.aav7259  0.44
2019 Bryant KL, Stalnecker CA, Zeitouni D, Klomp JE, Peng S, Tikunov AP, Gunda V, Pierobon M, Waters AM, George SD, Tomar G, Papke B, Hobbs GA, Yan L, Hayes TK, ... ... Der CJ, et al. Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer. Nature Medicine. PMID 30833752 DOI: 10.1038/s41591-019-0368-8  0.44
2018 Vaseva AV, Blake DR, Gilbert TSK, Ng S, Hostetter G, Azam SH, Ozkan-Dagliyan I, Gautam P, Bryant KL, Pearce KH, Herring LE, Han H, Graves LM, Witkiewicz AK, Knudsen ES, ... ... Der CJ, et al. KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism. Cancer Cell. 34: 807-822.e7. PMID 30423298 DOI: 10.1016/j.ccell.2018.10.001  0.44
2017 Waters AM, Ozkan-Dagliyan I, Vaseva AV, Fer N, Strathern LA, Hobbs GA, Tessier-Cloutier B, Gillette WK, Bagni R, Whiteley GR, Hartley JL, McCormick F, Cox AD, Houghton PJ, Huntsman DG, ... ... Der CJ, et al. Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies. Science Signaling. 10. PMID 28951536 DOI: 10.1126/scisignal.aao3332  0.44
2017 Stratford JK, Yan F, Hill RA, Major MB, Graves LM, Der CJ, Yeh JJ. Genetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability. Plos One. 12: e0174863. PMID 28380042 DOI: 10.1371/journal.pone.0174863  0.32
2017 Yin G, Kistler S, George SD, Kuhlmann N, Garvey L, Huynh M, Bagni RK, Lammers M, Der CJ, Campbell SL. A KRAS GTPase K104Q Mutant Retains Downstream Signaling by Offsetting Defects in Regulation. The Journal of Biological Chemistry. PMID 28154176 DOI: 10.1074/jbc.M116.762435  0.32
2017 Justilien V, Ali SA, Jamieson L, Yin N, Cox AD, Der CJ, Murray NR, Fields AP. Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma. Cancer Cell. PMID 28110998 DOI: 10.1016/j.ccell.2016.12.010  0.44
2016 Zhou B, Der CJ, Cox AD. The role of wild type RAS isoforms in cancer. Seminars in Cell & Developmental Biology. PMID 27422332 DOI: 10.1016/j.semcdb.2016.07.012  0.44
2016 Ryan MB, Finn AJ, Pedone KH, Thomas NE, Der CJ, Cox AD. ERK/MAPK Signaling Drives Overexpression of the Rac-GEF, PREX1, in BRAF- and NRAS-mutant Melanoma. Molecular Cancer Research : McR. PMID 27418645 DOI: 10.1158/1541-7786.MCR-16-0184  0.44
2016 Zhou B, Ritt DA, Morrison DK, Der CJ, Cox AD. CK2alpha Maintains ERK Activity in a Kinase-independent Manner to Promote Resistance to Inhibitors of RAF and MEK but not ERK in BRAF-mutant Melanoma. The Journal of Biological Chemistry. PMID 27226552 DOI: 10.1074/jbc.M115.712885  0.44
2016 Lawson CD, Fan C, Mitin N, Baker NM, George SD, Graham DM, Perou CM, Burridge K, Der CJ, Rossman KL. Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-activating Proteins in Basal-like Breast Cancers. Cancer Research. PMID 27216196 DOI: 10.1158/0008-5472.CAN-15-2923  1
2016 Zeitouni D, Pylayeva-Gupta Y, Der CJ, Bryant KL. KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment. Cancers. 8. PMID 27096871 DOI: 10.3390/cancers8040045  1
2016 Hobbs GA, Der CJ, Rossman KL. RAS isoforms and mutations in cancer at a glance. Journal of Cell Science. PMID 26985062 DOI: 10.1242/jcs.182873  1
2016 Hobbs GA, Wittinghofer A, Der CJ. Selective Targeting of the KRAS G12C Mutant: Kicking KRAS When It's Down. Cancer Cell. 29: 251-3. PMID 26977877 DOI: 10.1016/j.ccell.2016.02.015  1
2016 Gentry LR, Karginov AV, Hahn KM, Der CJ. Characterization of an engineered Src kinase to study Src signaling and biology Methods in Molecular Biology. 1360: 157-167. DOI: 10.1007/978-1-4939-3073-9_12  1
2015 Ryan MB, Der CJ, Wang-Gillam A, Cox AD. Targeting RAS-mutant cancers: is ERK the key? Trends in Cancer. 1: 183-198. PMID 26858988 DOI: 10.1016/j.trecan.2015.10.001  1
2015 Hayes TK, Neel NF, Hu C, Gautam P, Chenard M, Long B, Aziz M, Kassner M, Bryant KL, Pierobon M, Marayati R, Kher S, George SD, Xu M, Wang-Gillam A, ... ... Der CJ, et al. Long-term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression. Cancer Cell. PMID 26725216 DOI: 10.1016/j.ccell.2015.11.011  1
2015 Philips MR, Der CJ. Seeing is believing: Ras dimers observed in live cells. Proceedings of the National Academy of Sciences of the United States of America. 112: 9793-4. PMID 26229079 DOI: 10.1073/pnas.1511805112  1
2015 Gentry LR, Nishimura A, Cox AD, Martin TD, Tsygankov D, Nishida M, Elston TC, Der CJ. Divergent Roles of CAAX Motif-Signaled Posttranslational Modifications in the Regulation and Subcellular Localization of Ral GTPases. The Journal of Biological Chemistry. PMID 26216878 DOI: 10.1074/jbc.M115.656710  1
2015 Kidd AR, Muñiz-Medina V, Der CJ, Cox AD, Reiner DJ. The C. elegans Chp/Wrch Ortholog CHW-1 Contributes to LIN-18/Ryk and LIN-17/Frizzled Signaling in Cell Polarity. Plos One. 10: e0133226. PMID 26208319 DOI: 10.1371/journal.pone.0133226  0.84
2015 Black JL, Harrell JC, Leisner TM, Fellmeth MJ, George SD, Reinhold D, Baker NM, Jones CD, Der CJ, Perou CM, Parise LV. CIB1 depletion impairs cell survival and tumor growth in triple-negative breast cancer. Breast Cancer Research and Treatment. PMID 26105795 DOI: 10.1007/s10549-015-3458-4  1
2015 Cox AD, Der CJ, Philips MR. Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery? Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 1819-27. PMID 25878363 DOI: 10.1158/1078-0432.CCR-14-3214  0.44
2015 Kim TY, Siesser PF, Rossman KL, Goldfarb D, Mackinnon K, Yan F, Yi X, MacCoss MJ, Moon RT, Der CJ, Major MB. Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase. Molecular and Cellular Biology. 35: 167-81. PMID 25332235 DOI: 10.1128/MCB.00857-14  1
2015 Cox AD, Der CJ, Philips MR. Targeting RAS membrane association: Back to the future for anti-RAS drug discovery? Clinical Cancer Research. 21: 1819-1827. DOI: 10.1158/1078-0432.CCR-14-3214  1
2014 Cox AD, Fesik SW, Kimmelman AC, Luo J, Der CJ. Drugging the undruggable RAS: Mission possible? Nature Reviews. Drug Discovery. 13: 828-51. PMID 25323927 DOI: 10.1038/nrd4389  1
2014 Baker NM, Yee Chow H, Chernoff J, Der CJ. Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 4740-6. PMID 25225063 DOI: 10.1158/1078-0432.CCR-13-1727  1
2014 Gentry LR, Martin TD, Reiner DJ, Der CJ. Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame. Biochimica Et Biophysica Acta. 1843: 2976-2988. PMID 25219551 DOI: 10.1016/j.bbamcr.2014.09.004  1
2014 Damoulakis G, Gambardella L, Rossman KL, Lawson CD, Anderson KE, Fukui Y, Welch HC, Der CJ, Stephens LR, Hawkins PT. P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils. Journal of Cell Science. 127: 2589-600. PMID 24659802 DOI: 10.1242/jcs.153049  1
2014 Martin TD, Chen XW, Kaplan RE, Saltiel AR, Walker CL, Reiner DJ, Der CJ. Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Molecular Cell. 53: 209-20. PMID 24389102 DOI: 10.1016/j.molcel.2013.12.004  1
2014 Bryant KL, Mancias JD, Kimmelman AC, Der CJ. KRAS: feeding pancreatic cancer proliferation. Trends in Biochemical Sciences. 39: 91-100. PMID 24388967 DOI: 10.1016/j.tibs.2013.12.004  1
2014 Cook DR, Rossman KL, Der CJ. Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease. Oncogene. 33: 4021-35. PMID 24037532 DOI: 10.1038/onc.2013.362  1
2014 Hayes TK, Stratford JK, Wang-Gillam A, Der CJ. RAS genes and cancer Ras Superfamily Small G Proteins: Biology and Mechanisms 1: General Features, Signaling. 2147483647: 157-171. DOI: 10.1007/978-3-7091-1806-1_7  1
2014 Hayes TK, Der CJ. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of RAS mutant cancers Ras Superfamily Small G Proteins: Biology and Mechanisms 1: General Features, Signaling. 2147483647: 135-156. DOI: 10.1007/978-3-7091-1806-1_6  1
2013 Gentry L, Samatar AA, Der CJ. Inhibitors of the ERK mitogen-activated protein kinase cascade for targeting RAS mutant cancers. The Enzymes. 34: 67-106. PMID 25034101 DOI: 10.1016/B978-0-12-420146-0.00004-4  1
2013 Vigil D, Der CJ. Inhibitors of the ROCK serine/threonine kinases: key effectors of the RhoA small GTPase. The Enzymes. 33: 193-212. PMID 25033806 DOI: 10.1016/B978-0-12-416749-0.00009-9  1
2013 Huff LP, Decristo MJ, Trembath D, Kuan PF, Yim M, Liu J, Cook DR, Miller CR, Der CJ, Cox AD. The Role of Ect2 Nuclear RhoGEF Activity in Ovarian Cancer Cell Transformation. Genes & Cancer. 4: 460-75. PMID 24386507 DOI: 10.1177/1947601913514851  1
2013 Williams KA, Zhang M, Xiang S, Hu C, Wu JY, Zhang S, Ryan M, Cox AD, Der CJ, Fang B, Koomen J, Haura E, Bepler G, Nicosia SV, Matthias P, et al. Extracellular signal-regulated kinase (ERK) phosphorylates histone deacetylase 6 (HDAC6) at serine 1035 to stimulate cell migration. The Journal of Biological Chemistry. 288: 33156-70. PMID 24089523 DOI: 10.1074/jbc.M113.472506  1
2013 Mitin N, Rossman KL, Currin R, Anne S, Marshall TW, Bear JE, Bautch VL, Der CJ. The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility. Plos One. 8: e66260. PMID 23825001 DOI: 10.1371/journal.pone.0066260  1
2013 Ngok SP, Geyer R, Kourtidis A, Mitin N, Feathers R, Der C, Anastasiadis PZ. TEM4 is a junctional Rho GEF required for cell-cell adhesion, monolayer integrity and barrier function. Journal of Cell Science. 126: 3271-7. PMID 23729734 DOI: 10.1242/jcs.123869  1
2013 Baker NM, Der CJ. Cancer: Drug for an 'undruggable' protein. Nature. 497: 577-8. PMID 23698372 DOI: 10.1038/nature12248  1
2013 Peters EC, Gossett AJ, Goldstein B, Der CJ, Reiner DJ. Redundant canonical and noncanonical Caenorhabditis elegans p21-activated kinase signaling governs distal tip cell migrations. G3 (Bethesda, Md.). 3: 181-95. PMID 23390595 DOI: 10.1534/g3.112.004416  1
2013 Hayes TK, Der CJ. Mutant and wild-type Ras: co-conspirators in cancer. Cancer Discovery. 3: 24-6. PMID 23319767 DOI: 10.1158/2159-8290.CD-12-0521  1
2013 Wang Y, Velho S, Vakiani E, Peng S, Bass AJ, Chu GC, Gierut J, Bugni JM, Der CJ, Philips M, Solit DB, Haigis KM. Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression. Cancer Discovery. 3: 294-307. PMID 23274911 DOI: 10.1158/2159-8290.CD-12-0198  1
2013 Pedone KH, Sells JL, Der CJ. Mutational activation of KRAS and BRAF in colorectal cancer Molecular Pathogenesis of Colorectal Cancer. 121-156. DOI: 10.1007/978-1-4614-8412-7_5  1
2012 Vigil D, Kim TY, Plachco A, Garton AJ, Castaldo L, Pachter JA, Dong H, Chen X, Tokar B, Campbell SL, Der CJ. ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion. Cancer Research. 72: 5338-47. PMID 22942252 DOI: 10.1158/0008-5472.CAN-11-2373  1
2012 Mitin N, Rossman KL, Der CJ. Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4. Plos One. 7: e41876. PMID 22911862 DOI: 10.1371/journal.pone.0041876  1
2012 Martin TD, Mitin N, Cox AD, Yeh JJ, Der CJ. Phosphorylation by protein kinase Cα regulates RalB small GTPase protein activation, subcellular localization, and effector utilization. The Journal of Biological Chemistry. 287: 14827-36. PMID 22393054 DOI: 10.1074/jbc.M112.344986  1
2012 Cox AD, Der CJ. The RAF inhibitor paradox revisited. Cancer Cell. 21: 147-9. PMID 22340588 DOI: 10.1016/j.ccr.2012.01.017  1
2012 Neel NF, Rossman KL, Martin TD, Hayes TK, Yeh JJ, Der CJ. The RalB small GTPase mediates formation of invadopodia through a GTPase-activating protein-independent function of the RalBP1/RLIP76 effector. Molecular and Cellular Biology. 32: 1374-86. PMID 22331470 DOI: 10.1128/MCB.06291-11  1
2012 Mitin N, Roberts PJ, Chenette EJ, Der CJ. Posttranslational lipid modification of Rho family small GTPases. Methods in Molecular Biology (Clifton, N.J.). 827: 87-95. PMID 22144269 DOI: 10.1007/978-1-61779-442-1_6  1
2011 Cook DR, Solski PA, Bultman SJ, Kauselmann G, Schoor M, Kuehn R, Friedman LS, Cowley DO, Van Dyke T, Yeh JJ, Johnson L, Der CJ. The ect2 rho Guanine nucleotide exchange factor is essential for early mouse development and normal cell cytokinesis and migration. Genes & Cancer. 2: 932-42. PMID 22701760 DOI: 10.1177/1947601912437035  1
2011 Stevens EV, Banet N, Onesto C, Plachco A, Alan JK, Nikolaishvili-Feinberg N, Midkiff BR, Kuan PF, Liu J, Miller CR, Vigil D, Graves LM, Der CJ. RhoGDI2 antagonizes ovarian carcinoma growth, invasion and metastasis. Small Gtpases. 2: 202-210. PMID 22145092 DOI: 10.4161/sgtp.2.4.17795  1
2011 Lindsay CR, Lawn S, Campbell AD, Faller WJ, Rambow F, Mort RL, Timpson P, Li A, Cammareri P, Ridgway RA, Morton JP, Doyle B, Hegarty S, Rafferty M, Murphy IG, ... ... Der C, et al. P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nature Communications. 2: 555. PMID 22109529 DOI: 10.1038/ncomms1560  1
2011 Stinchcombe TE, Der CJ. Are all KRAS mutations created equal? The Lancet. Oncology. 12: 717-8. PMID 21782508 DOI: 10.1016/S1470-2045(11)70200-5  0.44
2011 Neel NF, Martin TD, Stratford JK, Zand TP, Reiner DJ, Der CJ. The RalGEF-Ral Effector Signaling Network: The Road Less Traveled for Anti-Ras Drug Discovery. Genes & Cancer. 2: 275-87. PMID 21779498 DOI: 10.1177/1947601911407329  1
2011 Zand TP, Reiner DJ, Der CJ. Ras effector switching promotes divergent cell fates in C. elegans vulval patterning. Developmental Cell. 20: 84-96. PMID 21238927 DOI: 10.1016/j.devcel.2010.12.004  1
2011 Justilien V, Jameison L, Der CJ, Rossman KL, Fields AP. Oncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylation. The Journal of Biological Chemistry. 286: 8149-57. PMID 21189248 DOI: 10.1074/jbc.M110.196113  1
2011 Chenette EJ, Der CJ. Lipid Modification of Ras Superfamily GTPases: Not Just Membrane Glue Enzymes. 29: 59-95. DOI: 10.1016/B978-0-12-381339-8.00005-6  1
2010 Cox AD, Der CJ. Ras history: The saga continues. Small Gtpases. 1: 2-27. PMID 21686117 DOI: 10.4161/sgtp.1.1.12178  1
2010 Vigil D, Cherfils J, Rossman KL, Der CJ. Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nature Reviews. Cancer. 10: 842-57. PMID 21102635 DOI: 10.1038/nrc2960  1
2010 Campbell PM, Boufaied N, Fiordalisi JJ, Cox AD, Falardeau P, Der CJ, Gourdeau H. TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling. Journal of Molecular Signaling. 5: 18. PMID 21044336 DOI: 10.1186/1750-2187-5-18  0.44
2010 Roberts PJ, Stinchcombe TE, Der CJ, Socinski MA. Personalized medicine in non-small-cell lung cancer: is KRAS a useful marker in selecting patients for epidermal growth factor receptor-targeted therapy? Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 28: 4769-77. PMID 20921461 DOI: 10.1200/JCO.2009.27.4365  1
2010 Vigil D, Martin TD, Williams F, Yeh JJ, Campbell SL, Der CJ. Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms. The Journal of Biological Chemistry. 285: 34729-40. PMID 20801877 DOI: 10.1074/jbc.M110.116756  1
2010 Singh A, Boyer JL, Der CJ, Zohn IE. Transformation by a nucleotide-activated P2Y receptor is mediated by activation of Galphai, Galphaq and Rho-dependent signaling pathways. Journal of Molecular Signaling. 5: 11. PMID 20653955 DOI: 10.1186/1750-2187-5-11  1
2010 Stratford JK, Bentrem DJ, Anderson JM, Fan C, Volmar KA, Marron JS, Routh ED, Caskey LS, Samuel JC, Der CJ, Thorne LB, Calvo BF, Kim HJ, Talamonti MS, Iacobuzio-Donahue CA, et al. A six-gene signature predicts survival of patients with localized pancreatic ductal adenocarcinoma. Plos Medicine. 7: e1000307. PMID 20644708 DOI: 10.1371/journal.pmed.1000307  1
2010 Kidd AR, Snider JL, Martin TD, Graboski SF, Der CJ, Cox AD. Ras-related small GTPases RalA and RalB regulate cellular survival after ionizing radiation. International Journal of Radiation Oncology, Biology, Physics. 78: 205-12. PMID 20619549 DOI: 10.1016/j.ijrobp.2010.03.023  1
2010 Cox AD, Der CJ. The raf inhibitor paradox: unexpected consequences of targeted drugs. Cancer Cell. 17: 221-3. PMID 20227037 DOI: 10.1016/j.ccr.2010.02.029  1
2010 Stevens EV, Carpenter AW, Shin JH, Liu J, Der CJ, Schoenfisch MH. Nitric oxide-releasing silica nanoparticle inhibition of ovarian cancer cell growth. Molecular Pharmaceutics. 7: 775-85. PMID 20205473 DOI: 10.1021/mp9002865  1
2010 González-Pérez V, Reiner DJ, Alan JK, Mitchell C, Edwards LJ, Khazak V, Der CJ, Cox AD. Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells. Journal of Molecular Signaling. 5: 2. PMID 20178605 DOI: 10.1186/1750-2187-5-2  1
2010 Lim KH, Brady DC, Kashatus DF, Ancrile BB, Der CJ, Cox AD, Counter CM. Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. Molecular and Cellular Biology. 30: 508-23. PMID 19901077 DOI: 10.1128/MCB.00916-08  1
2010 Hanker AB, Mitin N, Wilder RS, Henske EP, Tamanoi F, Cox AD, Der CJ. Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling. Oncogene. 29: 380-91. PMID 19838215 DOI: 10.1038/onc.2009.336  1
2010 Hanker AB, Der CJ. The roles of ras family small GTPases in breast cancer Handbook of Cell Signaling, 2/E. 3: 2763-2772. DOI: 10.1016/B978-0-12-374145-5.00322-3  1
2009 Madigan JP, Bodemann BO, Brady DC, Dewar BJ, Keller PJ, Leitges M, Philips MR, Ridley AJ, Der CJ, Cox AD. Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation. The Biochemical Journal. 424: 153-61. PMID 19723022 DOI: 10.1042/BJ20082377  1
2009 Hanker AB, Healy KD, Nichols J, Der CJ. Romidepsin inhibits Ras-dependent growth transformation of NIH 3T3 fibroblasts and RIE-1 epithelial cells independently of Ras signaling inhibition. Journal of Molecular Signaling. 4: 5. PMID 19682393 DOI: 10.1186/1750-2187-4-5  1
2009 Matsuo Y, Campbell PM, Brekken RA, Sung B, Ouellette MM, Fleming JB, Aggarwal BB, Der CJ, Guha S. K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways. Molecular Cancer Research : McR. 7: 799-808. PMID 19509115 DOI: 10.1158/1541-7786.MCR-08-0577  1
2009 Yeh JJ, Routh ED, Rubinas T, Peacock J, Martin TD, Shen XJ, Sandler RS, Kim HJ, Keku TO, Der CJ. KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer. Molecular Cancer Therapeutics. 8: 834-43. PMID 19372556 DOI: 10.1158/1535-7163.MCT-08-0972  1
2009 Willard FS, Willard MD, Kimple AJ, Soundararajan M, Oestreich EA, Li X, Sowa NA, Kimple RJ, Doyle DA, Der CJ, Zylka MJ, Snider WD, Siderovski DP. Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector. Plos One. 4: e4884. PMID 19319189 DOI: 10.1371/journal.pone.0004884  1
2009 Kim TY, Vigil D, Der CJ, Juliano RL. Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility. Cancer Metastasis Reviews. 28: 77-83. PMID 19221866 DOI: 10.1007/s10555-008-9167-2  1
2009 Yang XY, Guan M, Vigil D, Der CJ, Lowy DR, Popescu NC. p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities. Oncogene. 28: 1401-9. PMID 19151751 DOI: 10.1038/onc.2008.498  1
2009 Cha JY, Maddileti S, Mitin N, Harden TK, Der CJ. Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform. The Journal of Biological Chemistry. 284: 6227-40. PMID 19103595 DOI: 10.1074/jbc.M803998200  1
2008 Kim TY, Healy KD, Der CJ, Sciaky N, Bang YJ, Juliano RL. Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration. The Journal of Biological Chemistry. 283: 32762-70. PMID 18786931 DOI: 10.1074/jbc.M800617200  1
2008 Roberts PJ, Mitin N, Keller PJ, Chenette EJ, Madigan JP, Currin RO, Cox AD, Wilson O, Kirschmeier P, Der CJ. Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. The Journal of Biological Chemistry. 283: 25150-63. PMID 18614539 DOI: 10.1074/jbc.M800882200  1
2008 Campbell PM, Lee KM, Ouellette MM, Kim HJ, Groehler AL, Khazak V, Der CJ. Ras-driven transformation of human nestin-positive pancreatic epithelial cells. Methods in Enzymology. 439: 451-65. PMID 18374182 DOI: 10.1016/S0076-6879(07)00431-4  1
2008 Reiner DJ, González-Pérez V, Der CJ, Cox AD. Use of Caenorhabditis elegans to evaluate inhibitors of Ras function in vivo. Methods in Enzymology. 439: 425-49. PMID 18374181 DOI: 10.1016/S0076-6879(07)00430-2  1
2008 Onesto C, Shutes A, Picard V, Schweighoffer F, Der CJ. Characterization of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. Methods in Enzymology. 439: 111-29. PMID 18374160 DOI: 10.1016/S0076-6879(07)00409-0  0.44
2008 Hanker AB, Morita S, Repasky GA, Ross DT, Seitz RS, Der CJ. Tools to study the function of the Ras-related, estrogen-regulated growth inhibitor in breast cancer. Methods in Enzymology. 439: 53-72. PMID 18374156 DOI: 10.1016/S0076-6879(07)00405-3  1
2008 Cha JY, Lambert QT, Reuther GW, Der CJ. Involvement of fibroblast growth factor receptor 2 isoform switching in mammary oncogenesis. Molecular Cancer Research : McR. 6: 435-45. PMID 18337450 DOI: 10.1158/1541-7786.MCR-07-0187  1
2008 Healy KD, Hodgson L, Kim TY, Shutes A, Maddileti S, Juliano RL, Hahn KM, Harden TK, Bang YJ, Der CJ. DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms. Molecular Carcinogenesis. 47: 326-37. PMID 17932950 DOI: 10.1002/mc.20389  1
2007 Shutes A, Onesto C, Picard V, Leblond B, Schweighoffer F, Der CJ. Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. The Journal of Biological Chemistry. 282: 35666-78. PMID 17932039 DOI: 10.1074/jbc.M703571200  0.44
2007 Falsetti SC, Wang DA, Peng H, Carrico D, Cox AD, Der CJ, Hamilton AD, Sebti SM. Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. Molecular and Cellular Biology. 27: 8003-14. PMID 17875936 DOI: 10.1128/MCB.00057-07  1
2007 Mitin N, Betts L, Yohe ME, Der CJ, Sondek J, Rossman KL. Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression. Nature Structural & Molecular Biology. 14: 814-23. PMID 17704816 DOI: 10.1038/nsmb1290  1
2007 Hao H, Muniz-Medina VM, Mehta H, Thomas NE, Khazak V, Der CJ, Shields JM. Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth. Molecular Cancer Therapeutics. 6: 2220-9. PMID 17699719 DOI: 10.1158/1535-7163.MCT-06-0728  1
2007 Roberts PJ, Der CJ. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene. 26: 3291-310. PMID 17496923 DOI: 10.1038/sj.onc.1210422  1
2007 Repasky GA, Zhou Y, Morita S, Der CJ. Ras-mediated intestinal epithelial cell transformation requires cyclooxygenase-2-induced prostaglandin E2 signaling. Molecular Carcinogenesis. 46: 958-70. PMID 17477350 DOI: 10.1002/mc.20333  0.84
2007 Yohe ME, Rossman KL, Gardner OS, Karnoub AE, Snyder JT, Gershburg S, Graves LM, Der CJ, Sondek J. Auto-inhibition of the Dbl family protein Tim by an N-terminal helical motif. The Journal of Biological Chemistry. 282: 13813-23. PMID 17337446 DOI: 10.1074/jbc.M700185200  1
2007 Campbell PM, Groehler AL, Lee KM, Ouellette MM, Khazak V, Der CJ. K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling. Cancer Research. 67: 2098-106. PMID 17332339 DOI: 10.1158/0008-5472.CAN-06-3752  1
2007 Shields JM, Thomas NE, Cregger M, Berger AJ, Leslie M, Torrice C, Hao H, Penland S, Arbiser J, Scott G, Zhou T, Bar-Eli M, Bear JE, Der CJ, Kaufmann WK, et al. Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma. Cancer Research. 67: 1502-12. PMID 17308088 DOI: 10.1158/0008-5472.CAN-06-3311  1
2006 Ongusaha PP, Kim HG, Boswell SA, Ridley AJ, Der CJ, Dotto GP, Kim YB, Aaronson SA, Lee SW. RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress. Current Biology : Cb. 16: 2466-72. PMID 17174923 DOI: 10.1016/j.cub.2006.10.056  1
2006 Lim KH, O'Hayer K, Adam SJ, Kendall SD, Campbell PM, Der CJ, Counter CM. Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells. Current Biology : Cb. 16: 2385-94. PMID 17174914 DOI: 10.1016/j.cub.2006.10.023  1
2006 Loomis RJ, Holmes DA, Elms A, Solski PA, Der CJ, Su L. Citron kinase, a RhoA effector, enhances HIV-1 virion production by modulating exocytosis. Traffic (Copenhagen, Denmark). 7: 1643-53. PMID 17118119 DOI: 10.1111/j.1600-0854.2006.00503.x  1
2006 Baines AT, Lim KH, Shields JM, Lambert JM, Counter CM, Der CJ, Cox AD. Use of retrovirus expression of interfering RNA to determine the contribution of activated K-Ras and ras effector expression to human tumor cell growth. Methods in Enzymology. 407: 556-74. PMID 16757353 DOI: 10.1016/S0076-6879(05)07045-X  1
2006 Key MD, Andres DA, Der CJ, Repasky GA. Characterization of RERG: an estrogen-regulated tumor suppressor gene. Methods in Enzymology. 407: 513-27. PMID 16757349 DOI: 10.1016/S0076-6879(05)07041-2  1
2006 Campbell PM, Singh A, Williams FJ, Frantz K, Ulkü AS, Kelley GG, Der CJ. Genetic and pharmacologic dissection of Ras effector utilization in oncogenesis. Methods in Enzymology. 407: 195-217. PMID 16757325 DOI: 10.1016/S0076-6879(05)07017-5  0.4
2006 Shutes A, Der CJ. Real-time in vitro measurement of intrinsic and Ras GAP-mediated GTP hydrolysis. Methods in Enzymology. 407: 9-22. PMID 16757310 DOI: 10.1016/S0076-6879(05)07002-3  0.44
2006 Kelly P, Moeller BJ, Juneja J, Booden MA, Der CJ, Daaka Y, Dewhirst MW, Fields TA, Casey PJ. The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. Proceedings of the National Academy of Sciences of the United States of America. 103: 8173-8. PMID 16705036 DOI: 10.1073/pnas.0510254103  1
2006 Chenette EJ, Mitin NY, Der CJ. Multiple sequence elements facilitate Chp Rho GTPase subcellular location, membrane association, and transforming activity. Molecular Biology of the Cell. 17: 3108-21. PMID 16641371 DOI: 10.1091/mbc.E05-09-0896  1
2006 Shutes A, Berzat AC, Chenette EJ, Cox AD, Der CJ. Biochemical analyses of the Wrch atypical Rho family GTPases. Methods in Enzymology. 406: 11-26. PMID 16472646 DOI: 10.1016/S0076-6879(06)06002-2  1
2006 Balch WE, Der CJ, Hall A. Methods in Enzymology: Preface Methods in Enzymology. 404: xvii-xviii. DOI: 10.1016/S0076-6879(05)04058-9  1
2006 Booden MA, Ulku AS, Der CJ. Cellular assays of oncogene transformation Cell Biology, Four-Volume Set. 1: 345-352. DOI: 10.1016/B978-012164730-8/50042-3  1
2005 Shutes A, Der CJ. Real-time in vitro measurement of GTP hydrolysis. Methods (San Diego, Calif.). 37: 183-89. PMID 16288887 DOI: 10.1016/j.ymeth.2005.05.019  0.44
2005 Capell BC, Erdos MR, Madigan JP, Fiordalisi JJ, Varga R, Conneely KN, Gordon LB, Der CJ, Cox AD, Collins FS. Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome. Proceedings of the National Academy of Sciences of the United States of America. 102: 12879-84. PMID 16129833 DOI: 10.1073/pnas.0506001102  1
2005 Mitin N, Rossman KL, Der CJ. Signaling interplay in Ras superfamily function. Current Biology : Cb. 15: R563-74. PMID 16051167 DOI: 10.1016/j.cub.2005.07.010  1
2005 Berzat AC, Buss JE, Chenette EJ, Weinbaum CA, Shutes A, Der CJ, Minden A, Cox AD. Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-regulated Cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif. The Journal of Biological Chemistry. 280: 33055-65. PMID 16046391 DOI: 10.1074/jbc.M507362200  1
2005 Lim KH, Baines AT, Fiordalisi JJ, Shipitsin M, Feig LA, Cox AD, Der CJ, Counter CM. Activation of RalA is critical for Ras-induced tumorigenesis of human cells. Cancer Cell. 7: 533-45. PMID 15950903 DOI: 10.1016/j.ccr.2005.04.030  1
2005 Pruitt K, Ulkü AS, Frantz K, Rojas RJ, Muniz-Medina VM, Rangnekar VM, Der CJ, Shields JM. Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells. The Journal of Biological Chemistry. 280: 23363-70. PMID 15831492 DOI: 10.1074/jbc.M503083200  1
2005 Wennerberg K, Rossman KL, Der CJ. The Ras superfamily at a glance. Journal of Cell Science. 118: 843-6. PMID 15731001 DOI: 10.1242/jcs.01660  1
2005 Rossman KL, Der CJ, Sondek J. GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nature Reviews. Molecular Cell Biology. 6: 167-80. PMID 15688002 DOI: 10.1038/nrm1587  1
2005 Chenette EJ, Abo A, Der CJ. Critical and distinct roles of amino- and carboxyl-terminal sequences in regulation of the biological activity of the Chp atypical Rho GTPase. The Journal of Biological Chemistry. 280: 13784-92. PMID 15664990 DOI: 10.1074/jbc.M411300200  1
2004 Palmby TR, Abe K, Karnoub AE, Der CJ. Vav transformation requires activation of multiple GTPases and regulation of gene expression. Molecular Cancer Research : McR. 2: 702-11. PMID 15634759  1
2004 Shutes A, Berzat AC, Cox AD, Der CJ. Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase. Current Biology : Cb. 14: 2052-6. PMID 15556869 DOI: 10.1016/j.cub.2004.11.011  1
2004 Zhang L, Zhang J, Lambert Q, Der CJ, Del Valle L, Miklossy J, Khalili K, Zhou Y, Pagano JS. Interferon regulatory factor 7 is associated with Epstein-Barr virus-transformed central nervous system lymphoma and has oncogenic properties. Journal of Virology. 78: 12987-95. PMID 15542650 DOI: 10.1128/JVI.78.23.12987-12995.2004  1
2004 Repasky GA, Chenette EJ, Der CJ. Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis? Trends in Cell Biology. 14: 639-47. PMID 15519853 DOI: 10.1016/j.tcb.2004.09.014  1
2004 Singh A, Karnoub AE, Palmby TR, Lengyel E, Sondek J, Der CJ. Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation. Oncogene. 23: 9369-80. PMID 15516977 DOI: 10.1038/sj.onc.1208182  1
2004 Collette J, Ulku AS, Der CJ, Jones A, Erickson AH. Enhanced cathepsin L expression is mediated by different Ras effector pathways in fibroblasts and epithelial cells. International Journal of Cancer. Journal International Du Cancer. 112: 190-9. PMID 15352030 DOI: 10.1002/ijc.20398  1
2004 Eckert LB, Repasky GA, Ulkü AS, McFall A, Zhou H, Sartor CI, Der CJ. Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis. Cancer Research. 64: 4585-92. PMID 15231670 DOI: 10.1158/0008-5472.CAN-04-0396  0.84
2004 Huntington JT, Shields JM, Der CJ, Wyatt CA, Benbow U, Slingluff CL, Brinckerhoff CE. Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells: role of BRAF mutation and fibroblast growth factor signaling. The Journal of Biological Chemistry. 279: 33168-76. PMID 15184373 DOI: 10.1074/jbc.M405102200  1
2004 Ellerbroek SM, Wennerberg K, Arthur WT, Dunty JM, Bowman DR, DeMali KA, Der C, Burridge K. SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis. Molecular Biology of the Cell. 15: 3309-19. PMID 15133129 DOI: 10.1091/mbc.E04-02-0146  1
2004 Solski PA, Wilder RS, Rossman KL, Sondek J, Cox AD, Campbell SL, Der CJ. Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation. The Journal of Biological Chemistry. 279: 25226-33. PMID 15073184 DOI: 10.1074/jbc.M313792200  1
2004 Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ. Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. The Journal of Biological Chemistry. 279: 22353-61. PMID 15031288 DOI: 10.1074/jbc.M312867200  1
2004 Karnoub AE, Symons M, Campbell SL, Der CJ. Molecular basis for Rho GTPase signaling specificity. Breast Cancer Research and Treatment. 84: 61-71. PMID 14999155 DOI: 10.1023/B:BREA.0000018427.84929.5c  0.32
2004 Booden MA, Eckert LB, Der CJ, Trejo J. Persistent signaling by dysregulated thrombin receptor trafficking promotes breast carcinoma cell invasion. Molecular and Cellular Biology. 24: 1990-9. PMID 14966279 DOI: 10.1128/MCB.24.5.1990-1999.2004  1
2004 Fuentes EJ, Der CJ, Lee AL. Ligand-dependent dynamics and intramolecular signaling in a PDZ domain. Journal of Molecular Biology. 335: 1105-15. PMID 14698303 DOI: 10.1016/j.jmb.2003.11.010  1
2003 Sebti SM, Der CJ. Opinion: Searching for the elusive targets of farnesyltransferase inhibitors. Nature Reviews. Cancer. 3: 945-51. PMID 14737124 DOI: 10.1038/nrc1234  1
2003 Ulkü AS, Schäfer R, Der CJ. Essential role of Raf in Ras transformation and deregulation of matrix metalloproteinase expression in ovarian epithelial cells. Molecular Cancer Research : McR. 1: 1077-88. PMID 14707291  0.4
2003 Cox AD, Der CJ. The dark side of Ras: regulation of apoptosis. Oncogene. 22: 8999-9006. PMID 14663478 DOI: 10.1038/sj.onc.1207111  1
2003 Wozniak MA, Desai R, Solski PA, Der CJ, Keely PJ. ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix. The Journal of Cell Biology. 163: 583-95. PMID 14610060 DOI: 10.1083/jcb.200305010  1
2003 Pruitt WM, Karnoub AE, Rakauskas AC, Guipponi M, Antonarakis SE, Kurakin A, Kay BK, Sondek J, Siderovski DP, Der CJ. Role of the pleckstrin homology domain in intersectin-L Dbl homology domain activation of Cdc42 and signaling. Biochimica Et Biophysica Acta. 1640: 61-8. PMID 12676355 DOI: 10.1016/S0167-4889(03)00002-8  1
2003 Fuentes EJ, Karnoub AE, Booden MA, Der CJ, Campbell SL. Critical role of the pleckstrin homology domain in Dbs signaling and growth regulation. The Journal of Biological Chemistry. 278: 21188-96. PMID 12637530 DOI: 10.1074/jbc.M211792200  1
2003 Ulkü AS, Der CJ. Ras signaling, deregulation of gene expression and oncogenesis. Cancer Treatment and Research. 115: 189-208. PMID 12613198  0.4
2003 Hii CS, Costabile M, Mayne GC, Der CJ, Murray AW, Ferrante A. Selective deficiency in protein kinase C isoenzyme expression and inadequacy in mitogen-activated protein kinase activation in cord blood T cells. The Biochemical Journal. 370: 497-503. PMID 12435268 DOI: 10.1042/BJ20021122  1
2003 Murphy GA, Cox AD, Der CJ. Role of R-Ras in Cell Growth Handbook of Cell Signaling. 2: 681-688. DOI: 10.1016/B978-012124546-7/50595-7  1
2002 Cox AD, Der CJ. Ras family signaling: therapeutic targeting. Cancer Biology & Therapy. 1: 599-606. PMID 12642680  1
2002 Wennerberg K, Ellerbroek SM, Liu RY, Karnoub AE, Burridge K, Der CJ. RhoG signals in parallel with Rac1 and Cdc42. The Journal of Biological Chemistry. 277: 47810-7. PMID 12376551 DOI: 10.1074/jbc.M203816200  1
2002 Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K. XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. The Journal of Biological Chemistry. 277: 42964-72. PMID 12221096 DOI: 10.1074/jbc.M207401200  1
2002 Solski PA, Helms W, Keely PJ, Su L, Der CJ. RhoA biological activity is dependent on prenylation but independent of specific isoprenoid modification. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 13: 363-73. PMID 12193475  1
2002 Hamad NM, Elconin JH, Karnoub AE, Bai W, Rich JN, Abraham RT, Der CJ, Counter CM. Distinct requirements for Ras oncogenesis in human versus mouse cells. Genes & Development. 16: 2045-57. PMID 12183360 DOI: 10.1101/gad.993902  1
2002 Palmby TR, Abe K, Der CJ. Critical role of the pleckstrin homology and cysteine-rich domains in Vav signaling and transforming activity. The Journal of Biological Chemistry. 277: 39350-9. PMID 12177050 DOI: 10.1074/jbc.M202641200  1
2002 Lambert JM, Lambert QT, Reuther GW, Malliri A, Siderovski DP, Sondek J, Collard JG, Der CJ. Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. Nature Cell Biology. 4: 621-5. PMID 12134164 DOI: 10.1038/ncb833  1
2002 Pruitt K, Pruitt WM, Bilter GK, Westwick JK, Der CJ. Raf-independent deregulation of p38 and JNK mitogen-activated protein kinases are critical for Ras transformation. The Journal of Biological Chemistry. 277: 31808-17. PMID 12082106 DOI: 10.1074/jbc.M203964200  0.88
2002 Booden MA, Siderovski DP, Der CJ. Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA. Molecular and Cellular Biology. 22: 4053-61. PMID 12024019 DOI: 10.1128/MCB.22.12.4053-4061.2002  1
2002 Snyder JT, Worthylake DK, Rossman KL, Betts L, Pruitt WM, Siderovski DP, Der CJ, Sondek J. Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nature Structural Biology. 9: 468-75. PMID 12006984 DOI: 10.1038/nsb796  1
2002 Booden MA, Campbell SL, Der CJ. Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation. Molecular and Cellular Biology. 22: 2487-97. PMID 11909943  0.32
2002 Shields JM, Mehta H, Pruitt K, Der CJ. Opposing roles of the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades in Ras-mediated downregulation of tropomyosin. Molecular and Cellular Biology. 22: 2304-17. PMID 11884615 DOI: 10.1128/MCB.22.7.2304-2317.2002  1
2002 Reuther GW, Lambert QT, Rebhun JF, Caligiuri MA, Quilliam LA, Der CJ. RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia. The Journal of Biological Chemistry. 277: 30508-14. PMID 11880369 DOI: 10.1074/jbc.M111330200  1
2002 Wolfman JC, Palmby T, Der CJ, Wolfman A. Cellular N-Ras promotes cell survival by downregulation of Jun N-terminal protein kinase and p38. Molecular and Cellular Biology. 22: 1589-606. PMID 11839824 DOI: 10.1128/MCB.22.5.1589-1606.2002  1
2002 Murphy GA, Graham SM, Morita S, Reks SE, Rogers-Graham K, Vojtek A, Kelley GG, Der CJ. Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation. The Journal of Biological Chemistry. 277: 9966-75. PMID 11788587 DOI: 10.1074/jbc.M109059200  0.4
2002 Shields JM, Rogers-Graham K, Der CJ. Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways Journal of Biological Chemistry. 277: 9790-9799. PMID 11773051 DOI: 10.1074/jbc.M110086200  1
2002 Lambert JM, Karnoub AE, Graves LM, Campbell SL, Der CJ. Role of MLK3-mediated activation of p70 S6 kinase in Rac1 transformation. The Journal of Biological Chemistry. 277: 4770-7. PMID 11713255 DOI: 10.1074/jbc.M109379200  1
2001 Shaw RJ, Paez JG, Curto M, Yaktine A, Pruitt WM, Saotome I, O'Bryan JP, Gupta V, Ratner N, Der CJ, Jacks T, McClatchey AI. The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Developmental Cell. 1: 63-72. PMID 11703924 DOI: 10.1016/S1534-5807(01)00009-0  1
2001 Karnoub AE, Worthylake DK, Rossman KL, Pruitt WM, Campbell SL, Sondek J, Der CJ. Molecular basis for Rac1 recognition by guanine nucleotide exchange factors. Nature Structural Biology. 8: 1037-41. PMID 11685227 DOI: 10.1038/nsb719  0.52
2001 Wing MR, Houston D, Kelley GG, Der CJ, Siderovski DP, Harden TK. Activation of Phospholipase C-ε by Heterotrimeric G Protein βγ-Subunits Journal of Biological Chemistry. 276: 48257-48261. PMID 11641393 DOI: 10.1074/jbc.C100574200  1
2001 Snyder JT, Rossman KL, Baumeister MA, Pruitt WM, Siderovski DP, Der CJ, Lemmon MA, Sondek J. Quantitative analysis of the effect of phosphoinositide interactions on the function of Dbl family proteins. The Journal of Biological Chemistry. 276: 45868-75. PMID 11577097 DOI: 10.1074/jbc.M106731200  1
2001 Finlin BS, Gau CL, Murphy GA, Shao H, Kimel T, Seitz RS, Chiu YF, Botstein D, Brown PO, Der CJ, Tamanoi F, Andres DA, Perou CM. RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer. The Journal of Biological Chemistry. 276: 42259-67. PMID 11533059 DOI: 10.1074/jbc.M105888200  1
2001 Pruitt K, Der CJ. Ras and Rho regulation of the cell cycle and oncogenesis. Cancer Letters. 171: 1-10. PMID 11485822 DOI: 10.1016/S0304-3835(01)00528-6  0.88
2001 Graham SM, Rogers-Graham K, Figueroa C, Der CJ, Vojtek AB. Analyses of TC21/R-Ras2 signaling and biological activity. Methods in Enzymology. 333: 203-16. PMID 11400337 DOI: 10.1016/S0076-6879(01)33057-4  0.4
2001 Reuther GW, Lambert QT, Booden MA, Wennerberg K, Becknell B, Marcucci G, Sondek J, Caligiuri MA, Der CJ. Leukemia-associated Rho Guanine Nucleotide Exchange Factor, a Dbl Family Protein Found Mutated in Leukemia, Causes Transformation by Activation of RhoA Journal of Biological Chemistry. 276: 27145-27151. PMID 11373293 DOI: 10.1074/jbc.M103565200  1
2001 Martin CB, Mahon GM, Klinger MB, Kay RJ, Symons M, Der CJ, Whitehead IP. The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways. Oncogene. 20: 1953-63. PMID 11360179 DOI: 10.1038/sj.onc.1204281  1
2001 Whitehead IP, Zohn IE, Der CJ. Rho GTPase-dependent transformation by G protein-coupled receptors Oncogene. 20: 1547-1555. PMID 11313901 DOI: 10.1038/sj.onc.1204188  1
2001 Fiordalisi JJ, Johnson RL, Ulkü AS, Der CJ, Cox AD. Mammalian expression vectors for Ras family proteins: generation and use of expression constructs to analyze Ras family function. Methods in Enzymology. 332: 3-36. PMID 11305105 DOI: 10.1016/S0076-6879(01)32189-4  1
2001 Shields JM, Der CJ, Powers S. Identification of Ras-regulated genes by representational difference analysis Methods in Enzymology. 332: 221-232. PMID 11305099 DOI: 10.1016/S0076-6879(01)32205-X  1
2001 Karnoub AE, Der CJ, Campbell SL. The insert region of Rac1 is essential for membrane ruffling but not cellular transformation. Molecular and Cellular Biology. 21: 2847-57. PMID 11283263 DOI: 10.1128/MCB.21.8.2847-2857.2001  0.32
2000 Gupta S, Plattner R, Der CJ, Stanbridge EJ. Dissection of Ras-dependent signaling pathways controlling aggressive tumor growth of human fibrosarcoma cells: Evidence for a potential novel pathway Molecular and Cellular Biology. 20: 9294-9306. PMID 11094080 DOI: 10.1128/MCB.20.24.9294-9306.2000  1
2000 Reuther GW, Lambert QT, Caligiuri MA, Der CJ. Identification and characterization of an activating TrkA deletion mutation in acute myeloid leukemia. Molecular and Cellular Biology. 20: 8655-66. PMID 11073967 DOI: 10.1128/MCB.20.23.8655-8666.2000  0.4
2000 Reuther GW, Buss JE, Quilliam LA, Clark GJ, Der CJ. Analysis of function and regulation of proteins that mediate signal transduction by use of lipid-modified plasma membrane-targeting sequences Methods in Enzymology. 327: 331-350. PMID 11044995 DOI: 10.1016/S0076-6879(00)27288-1  1
2000 Solski PA, Abe K, Der CJ. Analyses of transforming activity of Rho family activators. Methods in Enzymology. 325: 425-41. PMID 11036624  1
2000 Pruitt K, Pestell RG, Der CJ. Ras inactivation of the retinoblastoma pathway by distinct mechanisms in NIH 3T3 fibroblast and RIE-1 epithelial cells. The Journal of Biological Chemistry. 275: 40916-24. PMID 11007784 DOI: 10.1074/jbc.M006682200  1
2000 Der CJ, Balch WE. GTPase traffic control Nature. 405: 749-752. PMID 10866184 DOI: 10.1038/35015654  1
2000 Wang L, Zhang H, Solski PA, Hart MJ, Der CJ, Su L. Modulation of HIV-1 replication by a novel RhoA effector activity. Journal of Immunology (Baltimore, Md. : 1950). 164: 5369-74. PMID 10799900  1
2000 Williams JG, Drugan JK, Yi GS, Clark GJ, Der CJ, Campbell SL. Elucidation of binding determinants and functional consequences of Ras/Raf-cysteine-rich domain interactions. The Journal of Biological Chemistry. 275: 22172-9. PMID 10777480 DOI: 10.1074/jbc.M000397200  1
2000 Abe K, Rossman KL, Liu B, Ritola KD, Chiang D, Campbell SL, Burridge K, Der CJ. Vav2 is an activator of Cdc42, Rac1, and RhoA. The Journal of Biological Chemistry. 275: 10141-9. PMID 10744696 DOI: 10.1074/jbc.275.14.10141  1
2000 Shields JM, Pruitt K, McFall A, Shaub A, Der CJ. Understanding Ras: 'it ain't over 'til it's over'. Trends in Cell Biology. 10: 147-54. PMID 10740269 DOI: 10.1016/S0962-8924(00)01740-2  1
2000 Reuther GW, Der CJ. The Ras branch of small GTPases: Ras family members don't fall far from the tree. Current Opinion in Cell Biology. 12: 157-65. PMID 10712923 DOI: 10.1016/S0955-0674(99)00071-X  0.64
1999 Zhang H, Wang L, Kao S, Whitehead IP, Hart MJ, Liu B, Duus K, Burridge K, Der CJ, Su L. Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF. Current Biology : Cb. 9: 1271-4. PMID 10556093 DOI: 10.1016/S0960-9822(99)80511-9  1
1999 Whitehead IP, Lambert QT, Glaven JA, Abe K, Rossman KL, Mahon GM, Trzaskos JM, Kay R, Campbell SL, Der CJ. Dependence of Dbl and Dbs transformation on MEK and NF-κB activation Molecular and Cellular Biology. 19: 7759-7770. PMID 10523665 DOI: 10.1128/MCB.19.11.7759  1
1999 Abe K, Whitehead IP, O'Bryan JP, Der CJ. Involvement of NH2-terminal sequences in the negative regulation of Vav signaling and transforming activity Journal of Biological Chemistry. 274: 30410-30418. PMID 10521418 DOI: 10.1074/jbc.274.43.30410  1
1999 Sizemore N, Cox AD, Barnard JA, Oldham SM, Reynolds ER, Der CJ, Coffey RJ. Pharmacological inhibition of Ras-transformed epithelial cell growth is linked to down-regulation of epidermal growth factor-related peptides Gastroenterology. 117: 567-576. PMID 10464132 DOI: 10.1016/S0016-5085(99)70449-X  1
1999 Quilliam LA, Castro AF, Rogers-Graham KS, Martin CB, Der CJ, Bi C. M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6. The Journal of Biological Chemistry. 274: 23850-7. PMID 10446149 DOI: 10.1074/jbc.274.34.23850  1
1999 Murphy GA, Solski PA, Jillian SA, Pérez de la Ossa P, D'Eustachio P, Der CJ, Rush MG. Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth. Oncogene. 18: 3831-45. PMID 10445846 DOI: 10.1038/sj.onc.1202758  1
1999 Hussain NK, Yamabhai M, Ramjaun AR, Guy AM, Baranes D, O'Bryan JP, Der CJ, Kay BK, McPherson PS. Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells. The Journal of Biological Chemistry. 274: 15671-7. PMID 10336464 DOI: 10.1074/jbc.274.22.15671  1
1999 Plattner R, Gupta S, Khosravi-Far R, Sato KY, Perucho M, Der CJ, Stanbridge EJ. Differential contribution of the ERK and JNK mitogen-activated protein kinase cascades to ras transformation of HT1080 fibrosarcoma and DLD-1 colon carcinoma cells Oncogene. 18: 1807-1817. PMID 10086335 DOI: 10.1038/sj.onc.1202482  1
1999 Booden MA, Baker TL, Solski PA, Der CJ, Punke SG, Buss JE. A non-farnesylated Ha-Ras protein can be palmitoylated and trigger potent differentiation and transformation. The Journal of Biological Chemistry. 274: 1423-31. PMID 9880516 DOI: 10.1074/jbc.274.3.1423  0.64
1998 Tognon CE, Kirk HE, Passmore LA, Whitehead IP, Der CJ, Kay RJ. Regulation of RasGRP via a phorbol ester-responsive C1 domain Molecular and Cellular Biology. 18: 6995-7008. PMID 9819387 DOI: 10.1128/MCB.18.12.6995  1
1998 Zohn IM, Campbell SL, Khosravi-Far R, Rossman KL, Der CJ. Rho family proteins and Ras transformation: The RHOad less traveled gets congested Oncogene. 17: 1415-1438. PMID 9779988 DOI: 10.1038/sj.onc.1202181  1
1998 Campbell SL, Khosravi-Far R, Rossman KL, Clark GJ, Der CJ. Increasing complexity of Ras signaling Oncogene. 17: 1395-1413. PMID 9779987 DOI: 10.1038/sj.onc.1202174  1
1998 O'Bryan JP, Lambert QT, Der CJ. The src homology 2 and phosphotyrosine binding domains of the ShcC adaptor protein function as inhibitors of mitogenic signaling by the epidermal growth factor receptor. The Journal of Biological Chemistry. 273: 20431-7. PMID 9685397 DOI: 10.1074/jbc.273.32.20431  0.44
1998 Whitehead IP, Abe K, Gorski JL, Der CJ. CDC42 and FGD1 cause distinct signaling and transforming activities Molecular and Cellular Biology. 18: 4689-4697. PMID 9671479 DOI: 10.1128/MCB.18.8.4689  1
1998 Hii CS, Huang ZH, Bilney A, Costabile M, Murray AW, Rathjen DA, Der CJ, Ferrante A. Stimulation of p38 phosphorylation and activity by arachidonic acid in HeLa cells, HL60 promyelocytic leukemic cells, and human neutrophils. Evidence for cell type-specific activation of mitogen-activated protein kinases. The Journal of Biological Chemistry. 273: 19277-82. PMID 9668117 DOI: 10.1074/jbc.273.30.19277  1
1998 Westwick JK, Lee RJ, Lambert QT, Symons M, Pestell RG, Der CJ, Whitehead IP. Transforming potential of Dbl family proteins correlates with transcription from the cyclin D1 promoter but not with activation of Jun NH2-terminal kinase, p38/Mpk2, serum response factor, or c-Jun Journal of Biological Chemistry. 273: 16739-16747. PMID 9642229 DOI: 10.1074/jbc.273.27.16739  1
1998 Oldham SM, Cox AD, Reynolds ER, Sizemore NS, Coffey RJ, Der CJ. Ras, but not Src, transformation of RIE-1 epithelial cells is dependent on activation of the mitogen-activated protein kinase cascade Oncogene. 16: 2565-2573. PMID 9632133 DOI: 10.1038/sj.onc.1201784  1
1997 Keely PJ, Westwick JK, Whitehead IP, Der CJ, Parise LV. Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K Nature. 390: 632-636. PMID 9403696 DOI: 10.1038/37656  1
1997 Khosravi-Far R, Campbell S, Rossman KL, Der CJ. Increasing complexity of ras signal transduction: Involvement of rho family proteins Advances in Cancer Research. 72: 57-107. PMID 9338074 DOI: 10.1016/S0065-230X(08)60700-9  1
1997 Finco TS, Westwick JK, Norris JL, Beg AA, Der CJ, Baldwin AS. Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation. The Journal of Biological Chemistry. 272: 24113-6. PMID 9305854 DOI: 10.1074/jbc.272.39.24113  1
1997 Cox AD, Der CJ. Farnesyltransferase inhibitors and cancer treatment: Targeting simply ras? Biochimica Et Biophysica Acta - Reviews On Cancer. 1333. PMID 9294018 DOI: 10.1016/S0304-419X(97)00011-5  1
1997 Clark GJ, Drugan JK, Rossman KL, Carpenter JW, Rogers-Graham K, Fu H, Der CJ, Campbell SL. 14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain. The Journal of Biological Chemistry. 272: 20990-3. PMID 9261098 DOI: 10.1074/jbc.272.34.20990  1
1997 Clark GJ, Kinch MS, Rogers-Graham K, Sebti SM, Hamilton AD, Der CJ. The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation Journal of Biological Chemistry. 272: 10608-10615. PMID 9099708 DOI: 10.1074/jbc.272.16.10608  1
1997 Whitehead IP, Campbell S, Rossman KL, Der CJ. Dbl family proteins Biochimica Et Biophysica Acta - Reviews On Cancer. 1332: F1-F23. PMID 9061011 DOI: 10.1016/S0304-419X(96)00040-6  1
1997 Han J, Das B, Wei W, Van Aelst L, Mosteller RD, Khosravi-Far R, Westwick JK, Der CJ, Broek D. Lck regulates Vav activation of members of the Rho family of GTPases. Molecular and Cellular Biology. 17: 1346-53. PMID 9032261 DOI: 10.1128/MCB.17.3.1346  1
1997 Westwick JK, Lambert QT, Clark GJ, Symons M, Van Aelst L, Pestell RG, Der CJ. Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways. Molecular and Cellular Biology. 17: 1324-35. PMID 9032259  1
1997 Huff SY, Quilliam LA, Cox AD, Der CJ. R-Ras is regulated by activators and effectors distinct from those that control Ras function Oncogene. 14: 133-143. PMID 9010215 DOI: 10.1038/sj.onc.1200815  1
1997 Clark GJ, Westwick JK, Der CJ. p120 GAP modulates Ras activation of Jun kinases and transformation. The Journal of Biological Chemistry. 272: 1677-81. PMID 8999845 DOI: 10.1074/jbc.272.3.1677  0.36
1996 Peterson SN, Trabalzini L, Brtva TR, Fischer T, Altschuler DL, Martelli P, Lapetina EG, Der CJ, White GC. Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1. The Journal of Biological Chemistry. 271: 29903-8. PMID 8939933 DOI: 10.1074/jbc.271.47.29903  1
1996 Willumsen BM, Cox AD, Solski PA, Der CJ, Buss JE. Novel determinants of H-Ras plasma membrane localization and transformation. Oncogene. 13: 1901-9. PMID 8934536  1
1996 Biscardi JS, Denhez F, Buehler GF, Chesnutt DA, Baragona SC, O'Bryan JP, Der CJ, Fiordalisi JJ, Fults DW, Maness PF. Rek, a gene expressed in retina and brain, encodes a receptor tyrosine kinase of the Axl/Tyro3 family. The Journal of Biological Chemistry. 271: 29049-59. PMID 8910558 DOI: 10.1074/jbc.271.46.29049  1
1996 Quilliam LA, Lambert QT, Mickelson-Young LA, Westwick JK, Sparks AB, Kay BK, Jenkins NA, Gilbert DJ, Copeland NG, Der CJ. Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling. The Journal of Biological Chemistry. 271: 28772-6. PMID 8910519 DOI: 10.1074/jbc.271.46.28772  1
1996 Graham SM, Vojtek AB, Huff SY, Cox AD, Clark GJ, Cooper JA, Der CJ. TC21 causes transformation by Raf-independent signaling pathways Molecular and Cellular Biology. 16: 6132-6140. PMID 8887643 DOI: 10.1128/MCB.16.11.6132  1
1996 Whitehead IP, Khosravi-Far R, Kirk H, Trigo-Gonzalez G, Der CJ, Kayt R. Expression cloning of lsc, a novel oncogene with structural similarities to the Dbl family of guanine nucleotide exchange factors Journal of Biological Chemistry. 271: 18643-18650. PMID 8702517 DOI: 10.1074/jbc.271.31.18643  1
1996 Plattner R, Anderson MJ, Sato KY, Fasching CL, Der CJ, Stanbridge EJ. Loss of oncogenic ras expression does not correlate with loss of tumorigenicity in human cells. Proceedings of the National Academy of Sciences of the United States of America. 93: 6665-70. PMID 8692875 DOI: 10.1073/pnas.93.13.6665  1
1996 Khosravi-Far R, White MA, Westwick JK, Solski PA, Chrzanowska-Wodnicka M, Van Aelst L, Wigler MH, Der CJ. Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Molecular and Cellular Biology. 16: 3923-33. PMID 8668210  1
1996 Clark GJ, Drugan JK, Terrell RS, Bradham C, Der CJ, Bell RM, Campbell S. Peptides containing a consensus Ras binding sequence from Raf-1 and the GTPase activating protein NF1 inhibit Ras function Proceedings of the National Academy of Sciences of the United States of America. 93: 1577-1581. PMID 8643674 DOI: 10.1073/pnas.93.4.1577  1
1996 Quilliam LA, Hisaka MM, Zhong S, Lowry A, Mosteller RD, Han J, Drugan JK, Broek D, Campbell SL, Der CJ. Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors. The Journal of Biological Chemistry. 271: 11076-82. PMID 8626650 DOI: 10.1074/jbc.271.19.11076  1
1996 Galang CK, García-Ramírez J, Solski PA, Westwick JK, Der CJ, Neznanov NN, Oshima RG, Hauser CA. Oncogenic Neu/ErbB-2 increases ets, AP-1, and NF-kappaB-dependent gene expression, and inhibiting ets activation blocks Neu-mediated cellular transformation. The Journal of Biological Chemistry. 271: 7992-8. PMID 8626480 DOI: 10.1074/jbc.271.14.7992  1
1996 Chu Y, Solski PA, Khosravi-Far R, Der CJ, Kelly K. The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation. The Journal of Biological Chemistry. 271: 6497-501. PMID 8626452 DOI: 10.1074/jbc.271.11.6497  1
1996 Drugan JK, Khosravi-Far R, White MA, Der CJ, Sung YJ, Hwang YW, Campbell SL. Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation. The Journal of Biological Chemistry. 271: 233-7. PMID 8550565 DOI: 10.1074/jbc.271.1.233  1
1995 Overbeck AF, Brtva TR, Cox AD, Graham SM, Huff SY, Khosravi-Far R, Quilliam LA, Solski PA, Der CJ. Guanine nucleotide exchange factors: activators of Ras superfamily proteins. Molecular Reproduction and Development. 42: 468-76. PMID 8607978 DOI: 10.1002/mrd.1080420415  1
1995 Clark GJ, Cox AD, Graham SM, Der CJ. Biological assays for Ras transformation Methods in Enzymology. 255: 395-412. PMID 8524126 DOI: 10.1016/S0076-6879(95)55042-9  1
1995 Cox AD, Solski PA, Jordan JD, Der CJ. Analysis of Ras protein expression in mammalian cells. Methods in Enzymology. 255: 195-220. PMID 8524103 DOI: 10.1016/S0076-6879(95)55023-2  1
1995 Quilliam LA, Zhong S, Rabun KM, Carpenter JW, South TL, Der CJ, Campbell-Burk S. Biological and structural characterization of a Ras transforming mutation at the phenylalanine-156 residue, which is conserved in all members of the Ras superfamily Proceedings of the National Academy of Sciences of the United States of America. 92: 1272-1276. PMID 7877967 DOI: 10.1073/pnas.92.5.1272  1
1995 Prendergast GC, Khosravi-Far R, Solski PA, Kurzawa H, Lebowitz PF, Der CJ. Critical role of Rho in cell transformation by oncogenic Ras. Oncogene. 10: 2289-96. PMID 7784077  1
1995 Brtva TR, Drugan JK, Ghosh S, Terrell RS, Campbell-Burk S, Bell RM, Der CJ. Two distinct Raf domains mediate interaction with Ras. The Journal of Biological Chemistry. 270: 9809-12. PMID 7730360 DOI: 10.1074/jbc.270.17.9809  1
1995 Solski PA, Quilliam LA, Coats SG, Der CJ, Buss JE. Targeting proteins to membranes using signal sequences for lipid modification. Methods in Enzymology. 250: 435-54. PMID 7651170 DOI: 10.1016/0076-6879(95)50089-8  1
1995 Lerner EC, Qian Y, Blaskovich MA, Fossum RD, Vogt A, Sun J, Cox AD, Der CJ, Hamilton AD, Sebti SM. Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes Journal of Biological Chemistry. 270: 26802-26806. PMID 7592920 DOI: 10.1074/jbc.270.45.26802  1
1995 Khosravi-Far R, Solski PA, Clark GJ, Kinch MS, Der CJ. Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Molecular and Cellular Biology. 15: 6443-53. PMID 7565796  1
1995 Kinch MS, Clark GJ, Der CJ, Burridge K. Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia. The Journal of Cell Biology. 130: 461-71. PMID 7542250 DOI: 10.1083/jcb.130.2.461  1
1994 Quilliam LA, Kato K, Rabun KM, Hisaka MM, Huff SY, Campbell-Burk S, Der CJ. Identification of residues critical for Ras(17N) growth-inhibitory phenotype and for Ras interaction with guanine nucleotide exchange factors Molecular and Cellular Biology. 14: 1113-1121. PMID 8289792 DOI: 10.1128/MCB.14.2.1113  1
1994 Graham SM, Cox AD, Drivas G, Rush MG, D'Eustachio P, Der CJ. Aberrant function of the Ras-related protein TC21/R-Ras2 triggers malignant transformation Molecular and Cellular Biology. 14: 4108-4115. PMID 8196649 DOI: 10.1128/MCB.14.6.4108  1
1994 Quilliam LA, Huff SY, Rabun KM, Wei W, Park W, Broek D, Der CJ. Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity. Proceedings of the National Academy of Sciences of the United States of America. 91: 8512-6. PMID 8078913 DOI: 10.1073/pnas.91.18.8512  1
1994 Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M, Karin M, Brenner DA. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases Proceedings of the National Academy of Sciences of the United States of America. 91: 6030-6034. PMID 8016110 DOI: 10.1073/pnas.91.13.6030  1
1994 Khosravi-Far R, Chrzanowska-Wodnicka M, Solski PA, Eva A, Burridge K, Der CJ. Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic ras Molecular and Cellular Biology. 14: 6848-6857. PMID 7935402  1
1994 Jackson JH, Li JW, Buss JE, Der CJ, Cochrane CG. Polylysine domain of K-ras 4B protein is crucial for malignant transformation. Proceedings of the National Academy of Sciences of the United States of America. 91: 12730-4. PMID 7809111 DOI: 10.1073/pnas.91.26.12730  1
1994 Cox AD, Der CJ. Biological assays for cellular transformation Methods in Enzymology. 238: 277-294. PMID 7799794 DOI: 10.1016/0076-6879(94)38026-0  1
1994 Hauser CA, Der CJ, Cox AD. Transcriptional activation analysis of oncogene function Methods in Enzymology. 238: 271-276. PMID 7799793 DOI: 10.1016/0076-6879(94)38025-2  1
1993 Clark GJ, Quilliam LA, Hisaka MM, Der CJ. Differential antagonism of Ras biological activity by catalytic and Src homology domains of Ras GTPase activation protein Proceedings of the National Academy of Sciences of the United States of America. 90: 4887-4891. PMID 8506332 DOI: 10.1073/pnas.90.11.4887  1
1993 Cox AD, Graham SM, Solski PA, Buss JE, Der CJ. The carboxyl-terminal CXXX sequence of Gi alpha, but not Rab5 or Rab11, supports Ras processing and transforming activity. The Journal of Biological Chemistry. 268: 11548-52. PMID 8505289  1
1992 Kato K, Cox AD, Hisaka MM, Graham SM, Buss JE, Der CJ. Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity Proceedings of the National Academy of Sciences of the United States of America. 89: 6403-6407. PMID 1631135 DOI: 10.1073/pnas.89.14.6403  1
1992 Kahn RA, Der CJ, Bokoch GM. The ras superfamily of GTP-binding proteins: Guidelines on nomenclature Faseb Journal. 6: 2512-2513. PMID 1592203 DOI: 10.1096/fasebj.6.8.1592203  1
1992 Cox AD, Der CJ. Protein prenylation: more than just glue? Current Opinion in Cell Biology. 4: 1008-1016. PMID 1485954 DOI: 10.1016/0955-0674(92)90133-W  1
1992 Tisdale EJ, Bourne JR, Khosravi-Far R, Der CJ, Balch WE. GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex. The Journal of Cell Biology. 119: 749-61. PMID 1429835  1
1992 Chow M, Der CJ, Buss JE. Structure and biological effects of lipid modifications on proteins Current Opinion in Cell Biology. 4: 629-636. PMID 1419045 DOI: 10.1016/0955-0674(92)90082-N  1
1992 Cox AD, Hisaka MM, Buss JE, Der CJ. Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein Molecular and Cellular Biology. 12: 2606-2615. PMID 1375323 DOI: 10.1128/MCB.12.6.2606  1
1991 Plutner H, Cox AD, Pind S, Khosravi-Far R, Bourne JR, Schwaninger R, Der CJ, Balch WE. Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. The Journal of Cell Biology. 115: 31-43. PMID 1918138 DOI: 10.1083/jcb.115.1.31  1
1991 Buss JE, Quilliam LA, Kato K, Casey PJ, Solski PA, Wong G, Clark R, McCormick F, Bokoch GM, Der CJ. The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein. Molecular and Cellular Biology. 11: 1523-30. PMID 1899909  1
1991 Khosravi-Far R, Lutz RJ, Cox AD, Conroy L, Bourne JR, Sinensky M, Balch WE, Buss JE, Der CJ. Isoprenoid modification of rab proteins terminating in CC or CXC motifs. Proceedings of the National Academy of Sciences of the United States of America. 88: 6264-8. PMID 1648736 DOI: 10.1073/pnas.88.14.6264  1
1990 Jackson JH, Cochrane CG, Bourne JR, Solski PA, Buss JE, Der CJ. Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation. Proceedings of the National Academy of Sciences of the United States of America. 87: 3042-6. PMID 2183224  1
1990 Quilliam LA, Der CJ, Clark R, O'Rourke EC, Zhang K, McCormick F, Bokoch GM. Biochemical characterization of baculovirus-expressed rap1A/Krev-1 and its regulation by GTPase-activating proteins. Molecular and Cellular Biology. 10: 2901-8. PMID 2160589 DOI: 10.1128/MCB.10.6.2901  1
1989 Buss JE, Solski PA, Schaeffer JP, MacDonald MJ, Der CJ. Activation of cellular p21ras by myristoylation. Biochemical Society Transactions. 17: 867-9. PMID 2695362  1
1989 Casey PJ, Solski PA, Der CJ, Buss JE. p21ras is modified by a farnesyl isoprenoid. Proceedings of the National Academy of Sciences of the United States of America. 86: 8323-7. PMID 2682646  1
1989 Buss JE, Solski PA, Schaeffer JP, MacDonald MJ, Der CJ. Activation of the cellular proto-oncogene product p21Ras by addition of a myristylation signal. Science (New York, N.Y.). 243: 1600-3. PMID 2648572  0.84
1989 Diamond AM, Der CJ, Schwartz JL. Alterations in transformation efficiency by the ADPRT-inhibitor 3-aminobenzamide are oncogene specific. Carcinogenesis. 10: 383-5. PMID 2536301 DOI: 10.1093/carcin/10.2.383  1
1989 Weissman BE, Arboleda MJ, Kimoto KA, Macdonald MJ, Ochiai R, Der CJ. Activation of ras oncogenes in chemically transformed BALB/MK‐2 mouse keratinocytes Molecular Carcinogenesis. 2: 150-158. PMID 2506887 DOI: 10.1002/mc.2940020308  0.36
1988 Buss JE, Der CJ, Solski PA. The six amino-terminal amino acids of p60src are sufficient to cause myristylation of p21v-ras. Molecular and Cellular Biology. 8: 3960-3. PMID 3146693  1
1986 Geiser AG, Der CJ, Marshall CJ, Stanbridge EJ. Suppression of tumorigenicity with continued expression of the c-Ha-ras oncogene in EJ bladder carcinoma-human fibroblast hybrid cells Proceedings of the National Academy of Sciences of the United States of America. 83: 5209-5213. PMID 3523486 DOI: 10.1073/pnas.83.14.5209  1
1986 Der CJ, Pan BT, Cooper GM. rasH mutants deficient in GTP binding. Molecular and Cellular Biology. 6: 3291-4. PMID 3097518 DOI: 10.1128/MCB.6.9.3291  0.52
1983 Der CJ, Cooper GM. Altered gene products are associated with activation of cellular rasK genes in human lung and colon carcinomas. Cell. 32: 201-8. PMID 6825168 DOI: 10.1016/0092-8674(83)90510-X  0.4
1982 Stanbridge EJ, Der CJ, Doersen CJ, Nishimi RY, Peehl DM, Weissman BE, Wilkinson JE. Human cell hybrids: Analysis of transformation and tumorigenicity Science. 215: 252-259. PMID 7053574 DOI: 10.1126/science.7053574  1
1981 Der CJ, Stanbridge EJ. A tumor-specific membrane phosphoprotein marker in human cell hybrids Cell. 26: 429-438. PMID 7326746 DOI: 10.1016/0092-8674(81)90212-9  1
1980 Der CJ, Stanbridge EJ. Alterations in the extracellular matrix organization associated with the reexpression of tumorigenicity in human cell hybrids International Journal of Cancer. 26: 451-459. PMID 7251223 DOI: 10.1002/ijc.2910260410  1
1978 Der CJ, Stanbridge EJ. Lack of correlation between the decreased expression of cell surface LETS protein and tumorigenicity in human cell hybrids Cell. 15: 1241-1251. PMID 728999 DOI: 10.1016/0092-8674(78)90050-8  1
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