Mitchell A. Lazar - Publications

University of Pennsylvania, Philadelphia, PA, United States 
Molecular Biology, Cell Biology, Anatomy Biology

283 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Hauck AK, Mehmood R, Carpenter BJ, Frankfurter MT, Tackenberg MC, Inoue SI, Krieg MK, Cassim Bawa FN, Midha MK, Zundell DM, Batmanov K, Lazar MA. Nuclear receptor corepressors non-canonically drive glucocorticoid receptor-dependent activation of hepatic gluconeogenesis. Nature Metabolism. PMID 38622413 DOI: 10.1038/s42255-024-01029-4  0.364
2023 Woodie LN, Melink LC, Alberto AJ, Burrows M, Fortin SM, Chan CC, Hayes MR, Lazar MA. Hindbrain REV-ERB nuclear receptors regulate sensitivity to diet-induced obesity and brown adipose tissue pathophysiology. Molecular Metabolism. 101861. PMID 38142970 DOI: 10.1016/j.molmet.2023.101861  0.305
2023 Zhu K, Celwyn IJ, Guan D, Xiao Y, Wang X, Hu W, Jiang C, Cheng L, Casellas R, Lazar MA. An intrinsically disordered region controlling condensation of a circadian clock component and rhythmic transcription in the liver. Molecular Cell. 83: 3457-3469.e7. PMID 37802023 DOI: 10.1016/j.molcel.2023.09.010  0.33
2022 Richter HJ, Hauck AK, Batmanov K, Inoue SI, So BN, Kim M, Emmett MJ, Cohen RN, Lazar MA. Balanced control of thermogenesis by nuclear receptor corepressors in brown adipose tissue. Proceedings of the National Academy of Sciences of the United States of America. 119: e2205276119. PMID 35939699 DOI: 10.1073/pnas.2205276119  0.791
2022 Santoleri D, Lim HW, Emmett MJ, Stoute J, Gavin MJ, Sostre-Colón J, Uehara K, Welles JE, Liu KF, Lazar MA, Titchenell PM. Global-run on sequencing identifies as an Akt-dependent long noncoding RNA involved in insulin sensitivity. Iscience. 25: 104410. PMID 35663017 DOI: 10.1016/j.isci.2022.104410  0.801
2022 Hu W, Jiang C, Kim M, Xiao Y, Richter HJ, Guan D, Zhu K, Krusen BM, Roberts AN, Miller J, Steger DJ, Lazar MA. Isoform-specific functions of PPARγ in gene regulation and metabolism. Genes & Development. PMID 35273075 DOI: 10.1101/gad.349232.121  0.325
2021 Shabtai Y, Nagaraj NK, Batmanov K, Cho YW, Guan Y, Jiang C, Remsberg J, Forrest D, Lazar MA. A coregulator shift, rather than the canonical switch, underlies thyroid hormone action in the liver. Genes & Development. PMID 33602873 DOI: 10.1101/gad.345686.120  0.334
2021 Fang B, Guan D, Lazar MA. Using GRO-Seq to Measure Circadian Transcription and Discover Circadian Enhancers. Methods in Molecular Biology (Clifton, N.J.). 2130: 127-148. PMID 33284441 DOI: 10.1007/978-1-0716-0381-9_10  0.302
2020 Nguyen HCB, Adlanmerini M, Hauck AK, Lazar MA. Dichotomous engagement of HDAC3 activity governs inflammatory responses. Nature. PMID 32760002 DOI: 10.1038/S41586-020-2576-2  0.452
2020 Guan D, Xiong Y, Trinh TM, Xiao Y, Hu W, Jiang C, Dierickx P, Jang C, Rabinowitz JD, Lazar MA. The hepatocyte clock and feeding control chronophysiology of multiple liver cell types. Science (New York, N.Y.). PMID 32732282 DOI: 10.1126/Science.Aba8984  0.322
2020 Szigety KM, Liu F, Yuan CY, Moran DJ, Horrell J, Gochnauer HR, Cohen RN, Katz JP, Kaestner KH, Seykora JT, Tobias JW, Lazar MA, Xu M, Millar SE. HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity. Genes & Development. PMID 32467224 DOI: 10.1101/Gad.333674.119  0.438
2020 Hoon Kim Y, Lazar MA. Transcriptional Control of Circadian Rhythms and Metabolism: A Matter of Time and Space. Endocrine Reviews. PMID 32392281 DOI: 10.1210/Endrev/Bnaa014  0.358
2020 Angueira AR, Shapira SN, Ishibashi J, Sampat S, Sostre-Colón J, Emmett MJ, Titchenell PM, Lazar MA, Lim HW, Seale P. Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes. Cell Reports. 30: 2869-2878.e4. PMID 32130892 DOI: 10.1016/J.Celrep.2020.02.023  0.812
2020 Guan D, Lazar MA. 219-LB: The Hepatocyte Clock and Feeding Interdependently Control Chrono-Homeostasis of Multiple Liver Cell Types Diabetes. 69. DOI: 10.2337/Db20-219-Lb  0.329
2019 Guan D, Lazar MA. Shining light on dark matter in the genome. Proceedings of the National Academy of Sciences of the United States of America. PMID 31740615 DOI: 10.1073/Pnas.1918894116  0.371
2019 Kuo T, Kraakman MJ, Damle M, Gill R, Lazar MA, Accili D. Identification of as a human diabetes susceptibility gene with a role in β cell insulin secretion. Proceedings of the National Academy of Sciences of the United States of America. PMID 31527256 DOI: 10.1073/Pnas.1904311116  0.317
2019 Adlanmerini M, Carpenter BJ, Remsberg JR, Aubert Y, Peed LC, Richter HJ, Lazar MA. Circadian lipid synthesis in brown fat maintains murine body temperature during chronic cold. Proceedings of the National Academy of Sciences of the United States of America. PMID 31451658 DOI: 10.1073/Pnas.1909883116  0.331
2019 Jaitin DA, Adlung L, Thaiss CA, Weiner A, Li B, Descamps H, Lundgren P, Bleriot C, Liu Z, Deczkowska A, Keren-Shaul H, David E, Zmora N, Eldar SM, Lubezky N, ... ... Lazar MA, et al. Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner. Cell. PMID 31257031 DOI: 10.1016/J.Cell.2019.05.054  0.361
2019 Dierickx P, Emmett MJ, Jiang C, Uehara K, Liu M, Adlanmerini M, Lazar MA. SR9009 has REV-ERB-independent effects on cell proliferation and metabolism. Proceedings of the National Academy of Sciences of the United States of America. PMID 31127047 DOI: 10.1073/Pnas.1904226116  0.78
2019 Kuo T, Damle M, González BJ, Egli D, Lazar MA, Accili D. Induction of α cell-restricted Gc in dedifferentiating β cells contributes to stress-induced β-cell dysfunction. Jci Insight. 5. PMID 31120862 DOI: 10.1172/Jci.Insight.128351  0.327
2019 Dallner OS, Marinis JM, Lu YH, Birsoy K, Werner E, Fayzikhodjaeva G, Dill BD, Molina H, Moscati A, Kutalik Z, Marques-Vidal P, Kilpeläinen TO, Grarup N, Linneberg A, Zhang Y, ... ... Lazar MA, et al. Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity. Nature Medicine. PMID 30842678 DOI: 10.1038/S41591-019-0370-1  0.324
2019 Benson K, Hu W, Weller A, Bennett A, Chen E, Kheterpal S, Yoshino S, Wang L, Rabinowitz J, Voight B, Lazar M, Soccio R. MON-LB017 Natural Genetic Variation in Humans Determines Basal and PPAR-Inducible Expression of PM20D1, a Putative Thermogenic Gene Journal of the Endocrine Society. 3. DOI: 10.1210/Js.2019-Mon-Lb017  0.307
2019 Szigety K, Liu F, Katz J, Kaestner K, Lazar M, Millar S. 901 HDAC3 complexes with KLF4 and NCoR/SMRT to control epidermal gene expression Journal of Investigative Dermatology. 139. DOI: 10.1016/J.Jid.2019.03.977  0.348
2018 Hu W, Jiang C, Guan D, Dierickx P, Zhang R, Moscati A, Nadkarni GN, Steger DJ, Loos RJF, Hu C, Jia W, Soccio RE, Lazar MA. Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response. Cell Stem Cell. PMID 30639037 DOI: 10.1016/J.Stem.2018.11.018  0.377
2018 Koerner MV, FitzPatrick L, Selfridge J, Guy J, De Sousa D, Tillotson R, Kerr A, Sun Z, Lazar MA, Lyst MJ, Bird A. Toxicity of overexpressed MeCP2 is independent of HDAC3 activity. Genes & Development. PMID 30463906 DOI: 10.1101/Gad.320325.118  0.557
2018 Emmett MJ, Lazar MA. Integrative regulation of physiology by histone deacetylase 3. Nature Reviews. Molecular Cell Biology. PMID 30390028 DOI: 10.1038/S41580-018-0076-0  0.812
2018 Guan D, Xiong Y, Borck PC, Jang C, Doulias PT, Papazyan R, Fang B, Jiang C, Zhang Y, Briggs ER, Hu W, Steger D, Ischiropoulos H, Rabinowitz JD, Lazar MA. Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes. Cell. PMID 30057115 DOI: 10.1016/J.Cell.2018.06.031  0.369
2018 Nelson VL, Nguyen HCB, Garcìa-Cañaveras JC, Briggs ER, Ho WY, DiSpirito JR, Marinis JM, Hill DA, Lazar MA. PPARγ is a nexus controlling alternative activation of macrophages via glutamine metabolism. Genes & Development. PMID 30006480 DOI: 10.1101/Gad.312355.118  0.38
2018 Zhang Y, Dallner OS, Nakadai T, Fayzikhodjaeva G, Lu YH, Lazar MA, Roeder RG, Friedman JM. A noncanonical PPARγ/RXRα-binding sequence regulates leptin expression in response to changes in adipose tissue mass. Proceedings of the National Academy of Sciences of the United States of America. PMID 29891714 DOI: 10.1073/Pnas.1806366115  0.422
2018 Hill DA, Lim HW, Kim YH, Ho WY, Foong YH, Nelson VL, Nguyen HCB, Chegireddy K, Kim J, Habertheuer A, Vallabhajosyula P, Kambayashi T, Won KJ, Lazar MA. Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue. Proceedings of the National Academy of Sciences of the United States of America. PMID 29760084 DOI: 10.1073/Pnas.1802611115  0.34
2018 Razzoli M, Emmett MJ, Lazar MA, Bartolomucci A. β-Adrenergic receptors control brown adipose UCP-1 tone and cold response without affecting its circadian rhythmicity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201800452R. PMID 29715048 DOI: 10.1096/Fj.201800452R  0.772
2018 Kim YH, Marhon SA, Zhang Y, Steger DJ, Won KJ, Lazar MA. Rev-erbα dynamically modulates chromatin looping to control circadian gene transcription. Science (New York, N.Y.). PMID 29439026 DOI: 10.1126/Science.Aao6891  0.449
2018 Karavaeva I, Ma T, Sustarsic EG, Emmett MJ, Majd H, Jedrychowski MP, Keipert S, Madsen AN, Basse AL, Have CT, Hansen T, Hansen JB, Holst B, Schwartz TW, Jastroch M, ... ... Lazar MA, et al. Control of brown adipose thermogenesis by a cold-inducible, circadian mitochondrial transporter Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1859: e94. DOI: 10.1016/J.Bbabio.2018.09.279  0.73
2017 Jang JC, Li J, Gambini L, Batugedara HM, Sati S, Lazar MA, Fan L, Pellecchia M, Nair MG. Human resistin protects against endotoxic shock by blocking LPS-TLR4 interaction. Proceedings of the National Academy of Sciences of the United States of America. PMID 29133417 DOI: 10.1073/Pnas.1716015114  0.302
2017 Poleshko A, Shah PP, Gupta M, Babu A, Morley MP, Manderfield LJ, Ifkovits JL, Calderon D, Aghajanian H, Sierra-Pagán JE, Sun Z, Wang Q, Li L, Dubois NC, Morrisey EE, ... Lazar MA, et al. Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction. Cell. PMID 29033129 DOI: 10.1016/J.Cell.2017.09.018  0.566
2017 Armour SM, Remsberg JR, Damle M, Sidoli S, Ho WY, Li Z, Garcia BA, Lazar MA. An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides. Nature Communications. 8: 549. PMID 28916805 DOI: 10.1038/S41467-017-00772-5  0.393
2017 Zhang Y, Papazyan R, Damle M, Fang B, Jager J, Feng D, Peed LC, Guan D, Sun Z, Lazar MA. The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORα/γ. Genes & Development. PMID 28747429 DOI: 10.1101/Gad.302323.117  0.622
2017 Emmett MJ, Lim HW, Jager J, Richter HJ, Adlanmerini M, Peed LC, Briggs ER, Steger DJ, Ma T, Sims CA, Baur JA, Pei L, Won KJ, Seale P, Gerhart-Hines Z, ... Lazar MA, et al. Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge. Nature. PMID 28614293 DOI: 10.1038/Nature22819  0.788
2017 Titchenell PM, Lazar MA, Birnbaum MJ. Unraveling the Regulation of Hepatic Metabolism by Insulin. Trends in Endocrinology and Metabolism: Tem. PMID 28416361 DOI: 10.1016/J.Tem.2017.03.003  0.701
2017 Lazar MA. Maturing of the nuclear receptor family. The Journal of Clinical Investigation. 127: 1123-1125. PMID 28368290 DOI: 10.1172/Jci92949  0.375
2017 Soccio RE, Li Z, Chen ER, Foong YH, Benson KK, Dispirito JR, Mullican SE, Emmett MJ, Briggs ER, Peed LC, Dzeng RK, Medina CJ, Jolivert JF, Kissig M, Rajapurkar SR, ... ... Lazar MA, et al. Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice. The Journal of Clinical Investigation. PMID 28240605 DOI: 10.1172/Jci91211  0.766
2017 Remsberg JR, Ediger BN, Ho WY, Damle M, Li Z, Teng C, Lanzillotta C, Stoffers DA, Lazar MA. Deletion of histone deacetylase 3 in adult beta cells improves glucose tolerance via increased insulin secretion. Molecular Metabolism. 6: 30-37. PMID 28123935 DOI: 10.1016/J.Molmet.2016.11.007  0.415
2017 Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, Shao M, Gay DL, Ramos R, His TC, Oh JW, Wang X, Ramirez A, Konopelski SE, Elzein A, ... ... Lazar MA, et al. Regeneration of fat cells from myofibroblasts during wound healing. Science (New York, N.Y.). PMID 28059714 DOI: 10.1126/Science.Aai8792  0.349
2016 Hong S, Zhou W, Fang B, Lu W, Loro E, Damle M, Ding G, Jager J, Zhang S, Zhang Y, Feng D, Chu Q, Dill BD, Molina H, Khurana TS, ... ... Lazar MA, et al. Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion. Nature Medicine. PMID 27991918 DOI: 10.1038/Nm.4245  0.571
2016 Papazyan R, Zhang Y, Lazar MA. Genetic and epigenomic mechanisms of mammalian circadian transcription. Nature Structural & Molecular Biology. 23: 1045-1052. PMID 27922611 DOI: 10.1038/Nsmb.3324  0.352
2016 Papazyan R, Sun Z, Kim YH, Titchenell PM, Hill DA, Lu W, Damle M, Wan M, Zhang Y, Briggs ER, Rabinowitz JD, Lazar MA. Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP. Cell Metabolism. PMID 27866836 DOI: 10.1016/J.Cmet.2016.10.012  0.751
2016 Zhang Y, Fang B, Damle M, Guan D, Li Z, Kim YH, Gannon M, Lazar MA. HNF6 and Rev-erbα integrate hepatic lipid metabolism by overlapping and distinct transcriptional mechanisms. Genes & Development. PMID 27445394 DOI: 10.1101/Gad.281972.116  0.402
2016 Teng X, Emmett MJ, Lazar MA, Goldberg E, Rabinowitz JD. Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis. Acs Chemical Biology. PMID 27333189 DOI: 10.1021/Acschembio.6B00290  0.751
2016 Zhang L, He X, Liu L, Jiang M, Zhao C, Wang H, He D, Zheng T, Zhou X, Hassan A, Ma Z, Xin M, Sun Z, Lazar MA, Goldman SA, et al. Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch. Developmental Cell. 37: 582. PMID 27326936 DOI: 10.1016/J.Devcel.2016.06.004  0.504
2016 Jager J, Wang F, Fang B, Lim HW, Peed LC, Steger DJ, Won KJ, Kharitonenkov A, Adams AC, Lazar MA. The Nuclear Receptor Rev-erbα Regulates Adipose Tissue-Specific Fibroblast Growth Factor 21 (FGF21) Signaling. The Journal of Biological Chemistry. PMID 27002153 DOI: 10.1074/Jbc.M116.719120  0.635
2016 Zhang L, He X, Liu L, Jiang M, Zhao C, Wang H, He D, Zheng T, Zhou X, Hassan A, Ma Z, Xin M, Sun Z, Lazar MA, Goldman SA, et al. Hdac3 Interaction with p300 Histone Acetyltransferase Regulates the Oligodendrocyte and Astrocyte Lineage Fate Switch. Developmental Cell. 36: 316-330. PMID 26859354 DOI: 10.1016/J.Devcel.2016.01.002  0.545
2015 Altman BJ, Hsieh AL, Sengupta A, Krishnanaiah SY, Stine ZE, Walton ZE, Gouw AM, Venkataraman A, Li B, Goraksha-Hicks P, Diskin SJ, Bellovin DI, Simon MC, Rathmell JC, Lazar MA, et al. MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells. Cell Metabolism. 22: 1009-19. PMID 26387865 DOI: 10.1016/J.Cmet.2015.09.003  0.37
2015 Fang B, Lazar MA. Dissecting the Rev-erbα Cistrome and the Mechanisms Controlling Circadian Transcription in Liver. Cold Spring Harbor Symposia On Quantitative Biology. PMID 26370410 DOI: 10.1101/Sqb.2015.80.027508  0.434
2015 Soccio RE, Chen ER, Rajapurkar SR, Safabakhsh P, Marinis JM, Dispirito JR, Emmett MJ, Briggs ER, Fang B, Everett LJ, Lim HW, Won KJ, Steger DJ, Wu Y, Civelek M, ... ... Lazar MA, et al. Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo. Cell. 162: 33-44. PMID 26140591 DOI: 10.1016/J.Cell.2015.06.025  0.768
2015 Cohen DM, Won KJ, Nguyen N, Lazar MA, Chen C, Steger D. ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis. Elife. 4. PMID 26111340 DOI: 10.7554/Elife.06821  0.371
2015 Zhang Y, Fang B, Emmett MJ, Damle M, Sun Z, Feng D, Armour SM, Remsberg JR, Jager J, Soccio RE, Steger DJ, Lazar MA. GENE REGULATION. Discrete functions of nuclear receptor Rev-erbα couple metabolism to the clock. Science (New York, N.Y.). 348: 1488-92. PMID 26044300 DOI: 10.1126/Science.Aab3021  0.819
2015 Lim HW, Uhlenhaut NH, Rauch A, Weiner J, Hübner S, Hübner N, Won KJ, Lazar MA, Tuckermann J, Steger DJ. Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo. Genome Research. 25: 836-44. PMID 25957148 DOI: 10.1101/Gr.188581.114  0.463
2015 Harms MJ, Lim HW, Ho Y, Shapira SN, Ishibashi J, Rajakumari S, Steger DJ, Lazar MA, Won KJ, Seale P. PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program. Genes & Development. 29: 298-307. PMID 25644604 DOI: 10.1101/Gad.252734.114  0.413
2015 Jang JC, Chen G, Wang SH, Barnes MA, Chung JI, Camberis M, Le Gros G, Cooper PJ, Steel C, Nutman TB, Lazar MA, Nair MG. Macrophage-derived human resistin is induced in multiple helminth infections and promotes inflammatory monocytes and increased parasite burden. Plos Pathogens. 11: e1004579. PMID 25568944 DOI: 10.1371/Journal.Ppat.1004579  0.305
2015 Gerhart-Hines Z, Lazar MA. Rev-erbα and the circadian transcriptional regulation of metabolism Diabetes, Obesity and Metabolism. 17: 12-16. DOI: 10.1111/Dom.12510  0.401
2015 Soccio RE, Chen ER, Rajapurkar SR, Safabakhsh P, Marinis JM, Dispirito JR, Emmett MJ, Briggs ER, Fang B, Everett LJ, Lim HW, Won KJ, Steger DJ, Wu Y, Civelek M, ... ... Lazar MA, et al. Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response in Vivo Cell. 162: 33-44. DOI: 10.1016/j.cell.2015.06.025  0.706
2014 Fang B, Everett LJ, Jager J, Briggs E, Armour SM, Feng D, Roy A, Gerhart-Hines Z, Sun Z, Lazar MA. Circadian enhancers coordinate multiple phases of rhythmic gene transcription in vivo. Cell. 159: 1140-52. PMID 25416951 DOI: 10.1016/J.Cell.2014.10.022  0.63
2014 Lee JM, Wagner M, Xiao R, Kim KH, Feng D, Lazar MA, Moore DD. Nutrient-sensing nuclear receptors coordinate autophagy. Nature. 516: 112-5. PMID 25383539 DOI: 10.1038/Nature13961  0.576
2014 Gardini A, Baillat D, Cesaroni M, Hu D, Marinis JM, Wagner EJ, Lazar MA, Shilatifard A, Shiekhattar R. Integrator regulates transcriptional initiation and pause release following activation. Molecular Cell. 56: 128-39. PMID 25201415 DOI: 10.1016/J.Molcel.2014.08.004  0.369
2014 Everett LJ, Lazar MA. Nuclear receptor Rev-erbα: up, down, and all around. Trends in Endocrinology and Metabolism: Tem. 25: 586-92. PMID 25066191 DOI: 10.1016/J.Tem.2014.06.011  0.409
2014 Hoeksema MA, Gijbels MJ, Van den Bossche J, van der Velden S, Sijm A, Neele AE, Seijkens T, Stöger JL, Meiler S, Boshuizen MC, Dallinga-Thie GM, Levels JH, Boon L, Mullican SE, Spann NJ, ... ... Lazar MA, et al. Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions. Embo Molecular Medicine. 6: 1124-32. PMID 25007801 DOI: 10.15252/Emmm.201404170  0.339
2014 Lefterova MI, Haakonsson AK, Lazar MA, Mandrup S. PPARγ and the global map of adipogenesis and beyond. Trends in Endocrinology and Metabolism: Tem. 25: 293-302. PMID 24793638 DOI: 10.1016/J.Tem.2014.04.001  0.752
2014 Step SE, Lim HW, Marinis JM, Prokesch A, Steger DJ, You SH, Won KJ, Lazar MA. Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPARγ-driven enhancers. Genes & Development. 28: 1018-28. PMID 24788520 DOI: 10.1101/Gad.237628.114  0.805
2014 Lee S, Lee HC, Kwon YW, Lee SE, Cho Y, Kim J, Lee S, Kim JY, Lee J, Yang HM, Mook-Jung I, Nam KY, Chung J, Lazar MA, Kim HS. Adenylyl cyclase-associated protein 1 is a receptor for human resistin and mediates inflammatory actions of human monocytes. Cell Metabolism. 19: 484-97. PMID 24606903 DOI: 10.1016/J.Cmet.2014.01.013  0.372
2014 Lewandowski SL, Janardhan HP, Smee KM, Bachman M, Sun Z, Lazar MA, Trivedi CM. Histone deacetylase 3 modulates Tbx5 activity to regulate early cardiogenesis. Human Molecular Genetics. 23: 3801-9. PMID 24565863 DOI: 10.1093/Hmg/Ddu093  0.544
2014 Jager J, O'Brien WT, Manlove J, Krizman EN, Fang B, Gerhart-Hines Z, Robinson MB, Klein PS, Lazar MA. Behavioral changes and dopaminergic dysregulation in mice lacking the nuclear receptor Rev-erbα. Molecular Endocrinology (Baltimore, Md.). 28: 490-8. PMID 24552589 DOI: 10.1210/Me.2013-1351  0.351
2014 Altman BJ, Hsieh A, Gouw AM, Stine ZE, Venkataraman A, Bellovin DI, Diskin SJ, Lu W, Zhang S, Felsher DW, Maris JM, Lazar MA, Rabinowitz JD, Hogenesch JB, Dang CV. Abstract 2953: Rev-erbα modulates Myc-driven cancer cell growth and altered metabolism Cancer Research. 74: 2953-2953. DOI: 10.1158/1538-7445.Am2014-2953  0.337
2013 Sun Z, Feng D, Fang B, Mullican SE, You SH, Lim HW, Everett LJ, Nabel CS, Li Y, Selvakumaran V, Won KJ, Lazar MA. Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor. Molecular Cell. 52: 769-82. PMID 24268577 DOI: 10.1016/J.Molcel.2013.10.022  0.688
2013 Schupp M, Chen F, Briggs ER, Rao S, Pelzmann HJ, Pessentheiner AR, Bogner-Strauss JG, Lazar MA, Baldwin D, Prokesch A. Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues. Bmc Genomics. 14: 758. PMID 24191950 DOI: 10.1186/1471-2164-14-758  0.392
2013 Alenghat T, Osborne LC, Saenz SA, Kobuley D, Ziegler CG, Mullican SE, Choi I, Grunberg S, Sinha R, Wynosky-Dolfi M, Snyder A, Giacomin PR, Joyce KL, Hoang TB, Bewtra M, ... ... Lazar MA, et al. Histone deacetylase 3 coordinates commensal-bacteria-dependent intestinal homeostasis. Nature. 504: 153-7. PMID 24185009 DOI: 10.1038/Nature12687  0.76
2013 Wang F, Mullican SE, DiSpirito JR, Peed LC, Lazar MA. Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARγ. Proceedings of the National Academy of Sciences of the United States of America. 110: 18656-61. PMID 24167256 DOI: 10.1073/Pnas.1314863110  0.594
2013 Gerhart-Hines Z, Feng D, Emmett MJ, Everett LJ, Loro E, Briggs ER, Bugge A, Hou C, Ferrara C, Seale P, Pryma DA, Khurana TS, Lazar MA. The nuclear receptor Rev-erbα controls circadian thermogenic plasticity. Nature. 503: 410-3. PMID 24162845 DOI: 10.1038/Nature12642  0.792
2013 Mullican SE, Dispirito JR, Lazar MA. The orphan nuclear receptors at their 25-year reunion. Journal of Molecular Endocrinology. 51: T115-40. PMID 24096517 DOI: 10.1530/Jme-13-0212  0.371
2013 Schwartz DR, Briggs ER, Qatanani M, Sawaya H, Sebag IA, Picard MH, Scherrer-Crosbie M, Lazar MA. Human resistin in chemotherapy-induced heart failure in humanized male mice and in women treated for breast cancer. Endocrinology. 154: 4206-14. PMID 23981771 DOI: 10.1210/En.2013-1399  0.301
2013 Dispirito JR, Fang B, Wang F, Lazar MA. Pruning of the adipocyte peroxisome proliferator-activated receptor γ cistrome by hematopoietic master regulator PU.1. Molecular and Cellular Biology. 33: 3354-64. PMID 23775123 DOI: 10.1128/Mcb.00599-13  0.663
2013 Everett LJ, Lazar MA. Cell-specific integration of nuclear receptor function at the genome. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 5: 615-29. PMID 23757177 DOI: 10.1002/Wsbm.1231  0.437
2013 Everett LJ, Le Lay J, Lukovac S, Bernstein D, Steger DJ, Lazar MA, Kaestner KH. Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver. Bmc Genomics. 14: 337. PMID 23682854 DOI: 10.1186/1471-2164-14-337  0.421
2013 You SH, Lim HW, Sun Z, Broache M, Won KJ, Lazar MA. Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo. Nature Structural & Molecular Biology. 20: 182-7. PMID 23292142 DOI: 10.1038/Nsmb.2476  0.57
2013 Mullican SE, Tomaru T, Gaddis CA, Peed LC, Sundaram A, Lazar MA. A novel adipose-specific gene deletion model demonstrates potential pitfalls of existing methods. Molecular Endocrinology (Baltimore, Md.). 27: 127-34. PMID 23192980 DOI: 10.1210/Me.2012-1267  0.354
2013 Cristancho AG, Lazar MA. Double SET point: G9a makes its mark in adipogenesis. The Embo Journal. 32: 4-6. PMID 23188078 DOI: 10.1038/Emboj.2012.320  0.766
2013 Sun Z, Lazar MA. Dissociating fatty liver and diabetes. Trends in Endocrinology and Metabolism: Tem. 24: 4-12. PMID 23043895 DOI: 10.1016/J.Tem.2012.09.005  0.485
2012 Yan Q, Carmody RJ, Qu Z, Ruan Q, Jager J, Mullican SE, Lazar MA, Chen YH. Nuclear factor-κB binding motifs specify Toll-like receptor-induced gene repression through an inducible repressosome. Proceedings of the National Academy of Sciences of the United States of America. 109: 14140-5. PMID 22891325 DOI: 10.1073/Pnas.1119842109  0.379
2012 Feng D, Lazar MA. Clocks, metabolism, and the epigenome. Molecular Cell. 47: 158-67. PMID 22841001 DOI: 10.1016/J.Molcel.2012.06.026  0.485
2012 Sinha RA, You SH, Zhou J, Siddique MM, Bay BH, Zhu X, Privalsky ML, Cheng SY, Stevens RD, Summers SA, Newgard CB, Lazar MA, Yen PM. Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. The Journal of Clinical Investigation. 122: 2428-38. PMID 22684107 DOI: 10.1172/Jci60580  0.594
2012 Sun Z, Miller RA, Patel RT, Chen J, Dhir R, Wang H, Zhang D, Graham MJ, Unterman TG, Shulman GI, Sztalryd C, Bennett MJ, Ahima RS, Birnbaum MJ, Lazar MA. Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nature Medicine. 18: 934-42. PMID 22561686 DOI: 10.1038/Nm.2744  0.521
2012 Bugge A, Feng D, Everett LJ, Briggs ER, Mullican SE, Wang F, Jager J, Lazar MA. Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function. Genes & Development. 26: 657-67. PMID 22474260 DOI: 10.1101/Gad.186858.112  0.673
2012 Lazar MA. Up, down, and all around the epigenomic regulation of metabolism Bmc Proceedings. 6. DOI: 10.1186/1753-6561-6-S3-O14  0.436
2011 Mullican SE, Gaddis CA, Alenghat T, Nair MG, Giacomin PR, Everett LJ, Feng D, Steger DJ, Schug J, Artis D, Lazar MA. Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation. Genes & Development. 25: 2480-8. PMID 22156208 DOI: 10.1101/Gad.175950.111  0.778
2011 Singh N, Trivedi CM, Lu M, Mullican SE, Lazar MA, Epstein JA. Histone deacetylase 3 regulates smooth muscle differentiation in neural crest cells and development of the cardiac outflow tract. Circulation Research. 109: 1240-9. PMID 21959220 DOI: 10.1161/Circresaha.111.255067  0.309
2011 Cristancho AG, Lazar MA. Forming functional fat: a growing understanding of adipocyte differentiation. Nature Reviews. Molecular Cell Biology. 12: 722-34. PMID 21952300 DOI: 10.1038/Nrm3198  0.79
2011 Cristancho AG, Schupp M, Lefterova MI, Cao S, Cohen DM, Chen CS, Steger DJ, Lazar MA. Repressor transcription factor 7-like 1 promotes adipogenic competency in precursor cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 16271-6. PMID 21914845 DOI: 10.1073/Pnas.1109409108  0.82
2011 Sun Z, Feng D, Everett LJ, Bugge A, Lazar MA. Circadian epigenomic remodeling and hepatic lipogenesis: lessons from HDAC3. Cold Spring Harbor Symposia On Quantitative Biology. 76: 49-55. PMID 21900149 DOI: 10.1101/Sqb.2011.76.011494  0.669
2011 Sun Z, Singh N, Mullican SE, Everett LJ, Li L, Yuan L, Liu X, Epstein JA, Lazar MA. Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle. The Journal of Biological Chemistry. 286: 33301-9. PMID 21808063 DOI: 10.1074/Jbc.M111.277707  0.513
2011 Steger DJ, Lazar MA. Adipogenic hotspots: where the action is. The Embo Journal. 30: 1418-9. PMID 21505519 DOI: 10.1038/Emboj.2011.80  0.421
2011 Feng D, Liu T, Sun Z, Bugge A, Mullican SE, Alenghat T, Liu XS, Lazar MA. A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science (New York, N.Y.). 331: 1315-9. PMID 21393543 DOI: 10.1126/Science.1198125  0.789
2011 Soccio RE, Tuteja G, Everett LJ, Li Z, Lazar MA, Kaestner KH. Species-specific strategies underlying conserved functions of metabolic transcription factors. Molecular Endocrinology (Baltimore, Md.). 25: 694-706. PMID 21292830 DOI: 10.1210/Me.2010-0454  0.41
2011 Park HK, Qatanani M, Briggs ER, Ahima RS, Lazar MA. Inflammatory induction of human resistin causes insulin resistance in endotoxemic mice. Diabetes. 60: 775-83. PMID 21282361 DOI: 10.2337/Db10-1416  0.314
2011 McQuown SC, Barrett RM, Matheos DP, Post RJ, Rogge GA, Alenghat T, Mullican SE, Jones S, Rusche JR, Lazar MA, Wood MA. HDAC3 is a critical negative regulator of long-term memory formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 764-74. PMID 21228185 DOI: 10.1523/Jneurosci.5052-10.2011  0.702
2011 Roszer T, Menéndez-Gutiérrez MP, Lefterova MI, Alameda D, Núñez V, Lazar MA, Fischer T, Ricote M. Autoimmune kidney disease and impaired engulfment of apoptotic cells in mice with macrophage peroxisome proliferator-activated receptor gamma or retinoid X receptor alpha deficiency. Journal of Immunology (Baltimore, Md. : 1950). 186: 621-31. PMID 21135166 DOI: 10.4049/Jimmunol.1002230  0.691
2010 Schupp M, Lazar MA. Endogenous ligands for nuclear receptors: digging deeper. The Journal of Biological Chemistry. 285: 40409-15. PMID 20956526 DOI: 10.1074/Jbc.R110.182451  0.407
2010 Tong X, Muchnik M, Chen Z, Patel M, Wu N, Joshi S, Rui L, Lazar MA, Yin L. Transcriptional repressor E4-binding protein 4 (E4BP4) regulates metabolic hormone fibroblast growth factor 21 (FGF21) during circadian cycles and feeding. The Journal of Biological Chemistry. 285: 36401-9. PMID 20851878 DOI: 10.1074/Jbc.M110.172866  0.497
2010 Grant D, Yin L, Collins JL, Parks DJ, Orband-Miller LA, Wisely GB, Joshi S, Lazar MA, Willson TM, Zuercher WJ. GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα. Acs Chemical Biology. 5: 925-32. PMID 20677822 DOI: 10.1021/Cb100141Y  0.448
2010 Phelan CA, Gampe RT, Lambert MH, Parks DJ, Montana V, Bynum J, Broderick TM, Hu X, Williams SP, Nolte RT, Lazar MA. Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction. Nature Structural & Molecular Biology. 17: 808-14. PMID 20581824 DOI: 10.1038/Nsmb.1860  0.368
2010 Yin L, Joshi S, Wu N, Tong X, Lazar MA. E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha. Proceedings of the National Academy of Sciences of the United States of America. 107: 11614-9. PMID 20534529 DOI: 10.1073/Pnas.1000438107  0.448
2010 Steger DJ, Grant GR, Schupp M, Tomaru T, Lefterova MI, Schug J, Manduchi E, Stoeckert CJ, Lazar MA. Propagation of adipogenic signals through an epigenomic transition state. Genes & Development. 24: 1035-44. PMID 20478996 DOI: 10.1101/Gad.1907110  0.734
2010 You SH, Liao X, Weiss RE, Lazar MA. The interaction between nuclear receptor corepressor and histone deacetylase 3 regulates both positive and negative thyroid hormone action in vivo. Molecular Endocrinology (Baltimore, Md.). 24: 1359-67. PMID 20427468 DOI: 10.1210/Jcem.95.5.9994  0.438
2010 Yin L, Wu N, Lazar MA. Nuclear receptor Rev-erbalpha: a heme receptor that coordinates circadian rhythm and metabolism. Nuclear Receptor Signaling. 8: e001. PMID 20414452 DOI: 10.1621/Nrs.08001  0.531
2010 Schupp M, Lazar MA. Fingered for a fat fate. Cell Metabolism. 11: 244-5. PMID 20374953 DOI: 10.1016/J.Cmet.2010.02.014  0.396
2010 Lefterova MI, Steger DJ, Zhuo D, Qatanani M, Mullican SE, Tuteja G, Manduchi E, Grant GR, Lazar MA. Cell-specific determinants of peroxisome proliferator-activated receptor gamma function in adipocytes and macrophages. Molecular and Cellular Biology. 30: 2078-89. PMID 20176806 DOI: 10.1128/Mcb.01651-09  0.76
2009 Wu N, Yin L, Hanniman EA, Joshi S, Lazar MA. Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha. Genes & Development. 23: 2201-9. PMID 19710360 DOI: 10.1101/Gad.1825809  0.505
2009 Lefterova MI, Mullican SE, Tomaru T, Qatanani M, Schupp M, Lazar MA. Endoplasmic reticulum stress regulates adipocyte resistin expression. Diabetes. 58: 1879-86. PMID 19491212 DOI: 10.2337/Db08-1706  0.71
2009 Germain P, Gaudon C, Pogenberg V, Sanglier S, Van Dorsselaer A, Royer CA, Lazar MA, Bourguet W, Gronemeyer H. Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists. Chemistry & Biology. 16: 479-89. PMID 19477412 DOI: 10.1016/J.Chembiol.2009.03.008  0.402
2009 McKenna NJ, Cooney AJ, DeMayo FJ, Downes M, Glass CK, Lanz RB, Lazar MA, Mangelsdorf DJ, Moore DD, Qin J, Steffen DL, Tsai MJ, Tsai SY, Yu R, Margolis RN, et al. Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. Molecular Endocrinology (Baltimore, Md.). 23: 740-6. PMID 19423650 DOI: 10.1210/Me.2009-0135  0.333
2009 Lefterova MI, Lazar MA. New developments in adipogenesis. Trends in Endocrinology and Metabolism: Tem. 20: 107-14. PMID 19269847 DOI: 10.1016/J.Tem.2008.11.005  0.721
2009 Qatanani M, Szwergold NR, Greaves DR, Ahima RS, Lazar MA. Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice. The Journal of Clinical Investigation. 119: 531-9. PMID 19188682 DOI: 10.1172/Jci37273  0.316
2009 Schupp M, Lefterova MI, Janke J, Leitner K, Cristancho AG, Mullican SE, Qatanani M, Szwergold N, Steger DJ, Curtin JC, Kim RJ, Suh MJ, Suh M, Albert MR, Engeli S, ... ... Lazar MA, et al. Retinol saturase promotes adipogenesis and is downregulated in obesity. Proceedings of the National Academy of Sciences of the United States of America. 106: 1105-10. PMID 19139408 DOI: 10.1073/Pnas.0812065106  0.819
2009 Schupp M, Cristancho AG, Lefterova MI, Hanniman EA, Briggs ER, Steger DJ, Qatanani M, Curtin JC, Schug J, Ochsner SA, McKenna NJ, Lazar MA. Re-expression of GATA2 cooperates with peroxisome proliferator-activated receptor-gamma depletion to revert the adipocyte phenotype. The Journal of Biological Chemistry. 284: 9458-64. PMID 19136559 DOI: 10.1074/Jbc.M809498200  0.829
2009 Tomaru T, Steger DJ, Lefterova MI, Schupp M, Lazar MA. Adipocyte-specific expression of murine resistin is mediated by synergism between peroxisome proliferator-activated receptor gamma and CCAAT/enhancer-binding proteins. The Journal of Biological Chemistry. 284: 6116-25. PMID 19126543 DOI: 10.1074/Jbc.M808407200  0.747
2008 Alenghat T, Meyers K, Mullican SE, Leitner K, Adeniji-Adele A, Avila J, Bućan M, Ahima RS, Kaestner KH, Lazar MA. Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology. Nature. 456: 997-1000. PMID 19037247 DOI: 10.1038/Nature07541  0.748
2008 Lefterova MI, Zhang Y, Steger DJ, Schupp M, Schug J, Cristancho A, Feng D, Zhuo D, Stoeckert CJ, Liu XS, Lazar MA. PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. Genes & Development. 22: 2941-52. PMID 18981473 DOI: 10.1101/gad.1709008  0.808
2008 Phelan CA, Weaver JM, Steger DJ, Joshi S, Maslany JT, Collins JL, Zuercher WJ, Willson TM, Walker M, Jaye M, Lazar MA. Selective partial agonism of liver X receptor alpha is related to differential corepressor recruitment. Molecular Endocrinology (Baltimore, Md.). 22: 2241-9. PMID 18669643 DOI: 10.1210/Me.2008-0041  0.408
2008 Kajimura S, Seale P, Tomaru T, Erdjument-Bromage H, Cooper MP, Ruas JL, Chin S, Tempst P, Lazar MA, Spiegelman BM. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes & Development. 22: 1397-409. PMID 18483224 DOI: 10.1101/Gad.1666108  0.397
2008 Steger DJ, Lefterova MI, Ying L, Stonestrom AJ, Schupp M, Zhuo D, Vakoc AL, Kim JE, Chen J, Lazar MA, Blobel GA, Vakoc CR. DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Molecular and Cellular Biology. 28: 2825-39. PMID 18285465 DOI: 10.1128/Mcb.02076-07  0.727
2008 Wang J, Lazar MA. Bifunctional role of Rev-erbalpha in adipocyte differentiation. Molecular and Cellular Biology. 28: 2213-20. PMID 18227153 DOI: 10.1128/Mcb.01608-07  0.424
2008 Hosooka T, Noguchi T, Kotani K, Nakamura T, Sakaue H, Inoue H, Ogawa W, Tobimatsu K, Takazawa K, Sakai M, Matsuki Y, Hiramatsu R, Yasuda T, Lazar MA, Yamanashi Y, et al. Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation. Nature Medicine. 14: 188-93. PMID 18204460 DOI: 10.1038/Nm1706  0.38
2008 Ahima RS, Lazar MA. Adipokines and the peripheral and neural control of energy balance. Molecular Endocrinology (Baltimore, Md.). 22: 1023-31. PMID 18202144 DOI: 10.1210/Me.2007-0529  0.32
2008 Moise AR, Domínguez M, Alvarez S, Alvarez R, Schupp M, Cristancho AG, Kiser PD, de Lera AR, Lazar MA, Palczewski K. Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids. Journal of the American Chemical Society. 130: 1154-5. PMID 18179220 DOI: 10.1021/Ja710487Q  0.745
2008 Shearer BG, Steger DJ, Way JM, Stanley TB, Lobe DC, Grillot DA, Iannone MA, Lazar MA, Willson TM, Billin AN. Identification and characterization of a selective peroxisome proliferator-activated receptor beta/delta (NR1C2) antagonist. Molecular Endocrinology (Baltimore, Md.). 22: 523-9. PMID 17975020 DOI: 10.1210/Me.2007-0190  0.361
2008 Alenghat T, Lazar MA. Nuclear receptor corepressors and metabolism Nr Coregulators and Human Diseases. 370-395. DOI: 10.1142/9789812819178_0011  0.733
2007 Singhal NS, Lazar MA, Ahima RS. Central resistin induces hepatic insulin resistance via neuropeptide Y. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 12924-32. PMID 18032666 DOI: 10.1523/Jneurosci.2443-07.2007  0.352
2007 Yin L, Wu N, Curtin JC, Qatanani M, Szwergold NR, Reid RA, Waitt GM, Parks DJ, Pearce KH, Wisely GB, Lazar MA. Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways. Science (New York, N.Y.). 318: 1786-9. PMID 18006707 DOI: 10.1126/Science.1150179  0.501
2007 Lazar MA. Resistin- and obesity-associated metabolic diseases Hormone and Metabolic Research. 39: 710-716. PMID 17952831 DOI: 10.1055/S-2007-985897  0.341
2007 Kershaw EE, Schupp M, Guan HP, Gardner NP, Lazar MA, Flier JS. PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo. American Journal of Physiology. Endocrinology and Metabolism. 293: E1736-45. PMID 17848638 DOI: 10.1152/Ajpendo.00122.2007  0.685
2007 Schambach F, Schupp M, Lazar MA, Reiner SL. Activation of retinoic acid receptor-alpha favours regulatory T cell induction at the expense of IL-17-secreting T helper cell differentiation. European Journal of Immunology. 37: 2396-9. PMID 17694576 DOI: 10.1002/Eji.200737621  0.321
2007 Lazar MA, Willson TM. Sweet dreams for LXR. Cell Metabolism. 5: 159-61. PMID 17339022 DOI: 10.1016/J.Cmet.2007.02.001  0.437
2007 Schupp M, Curtin JC, Kim RJ, Billin AN, Lazar MA. A widely used retinoic acid receptor antagonist induces peroxisome proliferator-activated receptor-gamma activity. Molecular Pharmacology. 71: 1251-7. PMID 17290005 DOI: 10.1124/Mol.106.033662  0.435
2007 Lehrke M, Millington SC, Lefterova M, Cumaranatunge RG, Szapary P, Wilensky R, Rader DJ, Lazar MA, Reilly MP. CXCL16 is a marker of inflammation, atherosclerosis, and acute coronary syndromes in humans. Journal of the American College of Cardiology. 49: 442-9. PMID 17258089 DOI: 10.1016/J.Jacc.2006.09.034  0.666
2006 Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H. International Union of Pharmacology. LXIII. Retinoid X receptors. Pharmacological Reviews. 58: 760-72. PMID 17132853 DOI: 10.1124/Pr.58.4.7  0.374
2006 Michalik L, Auwerx J, Berger JP, Chatterjee VK, Glass CK, Gonzalez FJ, Grimaldi PA, Kadowaki T, Lazar MA, O'Rahilly S, Palmer CN, Plutzky J, Reddy JK, Spiegelman BM, Staels B, et al. International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacological Reviews. 58: 726-41. PMID 17132851 DOI: 10.1124/Pr.58.4.5  0.487
2006 Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H. International Union of Pharmacology. LX. Retinoic acid receptors. Pharmacological Reviews. 58: 712-25. PMID 17132850 DOI: 10.1124/Pr.58.4.4  0.375
2006 Qi Y, Nie Z, Lee YS, Singhal NS, Scherer PE, Lazar MA, Ahima RS. Loss of resistin improves glucose homeostasis in leptin deficiency. Diabetes. 55: 3083-90. PMID 17065346 DOI: 10.2337/Db05-0615  0.314
2006 McVay LD, Keilbaugh SA, Wong TM, Kierstein S, Shin ME, Lehrke M, Lefterova MI, Shifflett DE, Barnes SL, Cominelli F, Cohn SM, Hecht G, Lazar MA, Haczku A, Wu GD. Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis. The Journal of Clinical Investigation. 116: 2914-23. PMID 17024245 DOI: 10.1172/Jci28121  0.661
2006 Yu J, Palmer C, Alenghat T, Li Y, Kao G, Lazar MA. The corepressor silencing mediator for retinoid and thyroid hormone receptor facilitates cellular recovery from DNA double-strand breaks. Cancer Research. 66: 9316-22. PMID 16982777 DOI: 10.1158/0008-5472.Can-06-1902  0.785
2006 Li Y, Kao GD, Garcia BA, Shabanowitz J, Hunt DF, Qin J, Phelan C, Lazar MA. A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity. Genes & Development. 20: 2566-79. PMID 16980585 DOI: 10.1101/Gad.1455006  0.399
2006 Wang J, Yin L, Lazar MA. The orphan nuclear receptor Rev-erb alpha regulates circadian expression of plasminogen activator inhibitor type 1. The Journal of Biological Chemistry. 281: 33842-8. PMID 16968709 DOI: 10.1074/Jbc.M607873200  0.366
2006 Alenghat T, Yu J, Lazar MA. The N-CoR complex enables chromatin remodeler SNF2H to enhance repression by thyroid hormone receptor. The Embo Journal. 25: 3966-74. PMID 16917504 DOI: 10.1038/Sj.Emboj.7601280  0.835
2006 Poirier H, Shapiro JS, Kim RJ, Lazar MA. Nutritional supplementation with trans-10, cis-12-conjugated linoleic acid induces inflammation of white adipose tissue. Diabetes. 55: 1634-41. PMID 16731825 DOI: 10.2337/Db06-0036  0.361
2006 Yin L, Wang J, Klein PS, Lazar MA. Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock. Science (New York, N.Y.). 311: 1002-5. PMID 16484495 DOI: 10.1126/Science.1121613  0.383
2005 Lehrke M, Lazar MA. The many faces of PPARgamma. Cell. 123: 993-9. PMID 16360030 DOI: 10.1016/J.Cell.2005.11.026  0.459
2005 Lehrke M, Pascual G, Glass CK, Lazar MA. Gaining weight: the Keystone Symposium on PPAR and LXR. Genes & Development. 19: 1737-42. PMID 16077002 DOI: 10.1101/Gad.1341005  0.407
2005 Lehrke M, Lebherz C, Millington SC, Guan HP, Millar J, Rader DJ, Wilson JM, Lazar MA. Diet-dependent cardiovascular lipid metabolism controlled by hepatic LXRalpha. Cell Metabolism. 1: 297-308. PMID 16054077 DOI: 10.1016/J.Cmet.2005.04.005  0.619
2005 Chui PC, Guan HP, Lehrke M, Lazar MA. PPARgamma regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1. The Journal of Clinical Investigation. 115: 2244-56. PMID 16007265 DOI: 10.1172/Jci24130  0.766
2005 Graveleau C, Zaha VG, Mohajer A, Banerjee RR, Dudley-Rucker N, Steppan CM, Rajala MW, Scherer PE, Ahima RS, Lazar MA, Abel ED. Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action. The Journal of Biological Chemistry. 280: 31679-85. PMID 15983036 DOI: 10.1074/Jbc.M504008200  0.55
2005 Codina A, Love JD, Li Y, Lazar MA, Neuhaus D, Schwabe JW. Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors. Proceedings of the National Academy of Sciences of the United States of America. 102: 6009-14. PMID 15837933 DOI: 10.1073/Pnas.0500299102  0.406
2005 Hartman HB, Yu J, Alenghat T, Ishizuka T, Lazar MA. The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3. Embo Reports. 6: 445-51. PMID 15832170 DOI: 10.1038/Sj.Embor.7400391  0.815
2005 Gao Z, Chiao P, Zhang X, Zhang X, Lazar MA, Seto E, Young HA, Ye J. Coactivators and corepressors of NF-kappaB in IkappaB alpha gene promoter. The Journal of Biological Chemistry. 280: 21091-8. PMID 15811852 DOI: 10.1074/Jbc.M500754200  0.405
2005 Yin L, Lazar MA. The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene. Molecular Endocrinology (Baltimore, Md.). 19: 1452-9. PMID 15761026 DOI: 10.1210/Me.2005-0057  0.496
2005 Kamin D, Hadigan C, Lehrke M, Mazza S, Lazar MA, Grinspoon S. Resistin levels in human immunodeficiency virus-infected patients with lipoatrophy decrease in response to rosiglitazone. The Journal of Clinical Endocrinology and Metabolism. 90: 3423-6. PMID 15741250 DOI: 10.1210/Jc.2005-0287  0.305
2005 Lazar MA. PPAR gamma, 10 years later. Biochimie. 87: 9-13. PMID 15733730 DOI: 10.1016/J.Biochi.2004.10.021  0.373
2005 Ishizuka T, Lazar MA. The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor. Molecular Endocrinology (Baltimore, Md.). 19: 1443-51. PMID 15695367 DOI: 10.1210/Me.2005-0009  0.382
2005 Steppan CM, Wang J, Whiteman EL, Birnbaum MJ, Lazar MA. Activation of SOCS-3 by resistin. Molecular and Cellular Biology. 25: 1569-75. PMID 15684405 DOI: 10.1128/Mcb.25.4.1569-1575.2005  0.324
2005 Guan HP, Ishizuka T, Chui PC, Lehrke M, Lazar MA. Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes & Development. 19: 453-61. PMID 15681609 DOI: 10.1101/Gad.1263305  0.779
2004 Lehrke M, Reilly MP, Millington SC, Iqbal N, Rader DJ, Lazar MA. An inflammatory cascade leading to hyperresistinemia in humans. Plos Medicine. 1: e45. PMID 15578112 DOI: 10.1371/Journal.Pmed.0010045  0.307
2004 Wilson-Fritch L, Nicoloro S, Chouinard M, Lazar MA, Chui PC, Leszyk J, Straubhaar J, Czech MP, Corvera S. Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone Journal of Clinical Investigation. 114: 1281-1289. PMID 15520860 DOI: 10.1172/Jci21752  0.626
2004 Artis D, Wang ML, Keilbaugh SA, He W, Brenes M, Swain GP, Knight PA, Donaldson DD, Lazar MA, Miller HR, Schad GA, Scott P, Wu GD. RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract. Proceedings of the National Academy of Sciences of the United States of America. 101: 13596-600. PMID 15340149 DOI: 10.1073/Pnas.0404034101  0.525
2004 Rangwala SM, Lazar MA. Peroxisome proliferator-activated receptor gamma in diabetes and metabolism. Trends in Pharmacological Sciences. 25: 331-6. PMID 15165749 DOI: 10.1016/J.Tips.2004.03.012  0.423
2004 Hug BA, Lazar MA. ETO interacting proteins. Oncogene. 23: 4270-4. PMID 15156183 DOI: 10.1038/Sj.Onc.1207674  0.376
2004 Steppan CM, Lazar MA. The current biology of resistin. Journal of Internal Medicine. 255: 439-47. PMID 15049878 DOI: 10.1111/J.1365-2796.2004.01306.X  0.304
2004 Banerjee RR, Rangwala SM, Shapiro JS, Rich AS, Rhoades B, Qi Y, Wang J, Rajala MW, Pocai A, Scherer PE, Steppan CM, Ahima RS, Obici S, Rossetti L, Lazar MA. Regulation of fasted blood glucose by resistin. Science (New York, N.Y.). 303: 1195-8. PMID 14976316 DOI: 10.1126/Science.1092341  0.567
2004 Fanelli M, Fantozzi A, De Luca P, Caprodossi S, Matsuzawa S, Lazar MA, Pelicci PG, Minucci S. The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome. The Journal of Biological Chemistry. 279: 5374-9. PMID 14645235 DOI: 10.1074/Jbc.M306407200  0.339
2004 Hug BA, Ahmed N, Robbins JA, Lazar MA. A chromatin immunoprecipitation screen reveals protein kinase Cbeta as a direct RUNX1 target gene. The Journal of Biological Chemistry. 279: 825-30. PMID 14561740 DOI: 10.1074/Jbc.M309524200  0.387
2003 Lazar MA. Nuclear receptor corepressors. Nuclear Receptor Signaling. 1: e001. PMID 16604174 DOI: 10.1621/Nrs.01001  0.36
2003 Guenther MG, Lazar MA. Biochemical isolation and analysis of a nuclear receptor corepressor complex. Methods in Enzymology. 364: 246-57. PMID 14631849 DOI: 10.1016/S0076-6879(03)64014-0  0.737
2003 He W, Wang ML, Jiang HQ, Steppan CM, Shin ME, Thurnheer MC, Cebra JJ, Lazar MA, Wu GD. Bacterial colonization leads to the colonic secretion of RELMbeta/FIZZ2, a novel goblet cell-specific protein. Gastroenterology. 125: 1388-97. PMID 14598255 DOI: 10.1016/J.Gastro.2003.07.009  0.361
2003 Rangwala SM, Rhoades B, Shapiro JS, Rich AS, Kim JK, Shulman GI, Kaestner KH, Lazar MA. Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity. Developmental Cell. 5: 657-63. PMID 14536066 DOI: 10.1016/S1534-5807(03)00274-0  0.374
2003 Lazar MA. Thyroid hormone action: a binding contract. The Journal of Clinical Investigation. 112: 497-9. PMID 12925689 DOI: 10.1172/Jci19479  0.342
2003 Ishizuka T, Lazar MA. The N-CoR/histone deacetylase 3 complex is required for repression by thyroid hormone receptor. Molecular and Cellular Biology. 23: 5122-31. PMID 12861000 DOI: 10.1128/Mcb.23.15.5122-5131.2003  0.448
2003 Yu J, Li Y, Ishizuka T, Guenther MG, Lazar MA. A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation. The Embo Journal. 22: 3403-10. PMID 12840002 DOI: 10.1093/Emboj/Cdg326  0.812
2003 Banerjee RR, Lazar MA. Resistin: molecular history and prognosis. Journal of Molecular Medicine (Berlin, Germany). 81: 218-26. PMID 12700889 DOI: 10.1007/S00109-003-0428-9  0.634
2003 Kao GD, McKenna WG, Guenther MG, Muschel RJ, Lazar MA, Yen TJ. Histone deacetylase 4 interacts with 53BP1 to mediate the DNA damage response. The Journal of Cell Biology. 160: 1017-27. PMID 12668657 DOI: 10.1083/Jcb.200209065  0.677
2003 Guan H, Lazar MA. Reply to “A “futile cycle” induced by thiazolidinediones in human adipose tissue?” Nature Medicine. 9: 812-812. DOI: 10.1038/Nm0703-812  0.602
2002 Guenther MG, Yu J, Kao GD, Yen TJ, Lazar MA. Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. Genes & Development. 16: 3130-5. PMID 12502735 DOI: 10.1101/Gad.1037502  0.806
2002 Guan HP, Li Y, Jensen MV, Newgard CB, Steppan CM, Lazar MA. A futile metabolic cycle activated in adipocytes by antidiabetic agents. Nature Medicine. 8: 1122-8. PMID 12357248 DOI: 10.1038/Nm780  0.671
2002 Li Y, Lazar MA. Differential gene regulation by PPARgamma agonist and constitutively active PPARgamma2. Molecular Endocrinology (Baltimore, Md.). 16: 1040-8. PMID 11981038 DOI: 10.1210/Mend.16.5.0825  0.465
2002 Hartman HB, Hu X, Tyler KX, Dalal CK, Lazar MA. Mechanisms regulating adipocyte expression of resistin. The Journal of Biological Chemistry. 277: 19754-61. PMID 11901161 DOI: 10.1074/Jbc.M201451200  0.765
2002 Rangwala SM, Lazar MA. The dawn of the SPPARMs? Science's Stke : Signal Transduction Knowledge Environment. 2002: pe9. PMID 11867819 DOI: 10.1126/Stke.2002.121.Pe9  0.345
2002 Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E. Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Molecular Cell. 9: 45-57. PMID 11804585 DOI: 10.1016/S1097-2765(01)00429-4  0.724
2002 Steppan CM, Lazar MA. Resistin and obesity-associated insulin resistance Trends in Endocrinology and Metabolism. 13: 18-23. PMID 11750858 DOI: 10.1016/S1043-2760(01)00522-7  0.379
2002 Li Y, Lazar MA. Differential Gene Regulation by PPAR Agonist and Constitutively Active PPAR 2 Molecular Endocrinology. 16: 1040-1048. DOI: 10.1210/Me.16.5.1040  0.464
2001 Guenther MG, Barak O, Lazar MA. The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3. Molecular and Cellular Biology. 21: 6091-101. PMID 11509652 DOI: 10.1128/Mcb.21.18.6091-6101.2001  0.725
2001 Phiel CJ, Zhang F, Huang EY, Guenther MG, Lazar MA, Klein PS. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. The Journal of Biological Chemistry. 276: 36734-41. PMID 11473107 DOI: 10.1074/Jbc.M101287200  0.697
2001 Banerjee RR, Lazar MA. Dimerization of resistin and resistin-like molecules is determined by a single cysteine. The Journal of Biological Chemistry. 276: 25970-3. PMID 11358969 DOI: 10.1074/Jbc.M103109200  0.536
2001 Wang C, Fu M, D'Amico M, Albanese C, Zhou JN, Brownlee M, Lisanti MP, Chatterjee VK, Lazar MA, Pestell RG. Inhibition of cellular proliferation through IkappaB kinase-independent and peroxisome proliferator-activated receptor gamma-dependent repression of cyclin D1. Molecular and Cellular Biology. 21: 3057-70. PMID 11287611 DOI: 10.1128/Mcb.21.9.3057-3070.2001  0.369
2001 Hu X, Li Y, Lazar MA. Determinants of CoRNR-dependent repression complex assembly on nuclear hormone receptors Molecular and Cellular Biology. 21: 1747-1758. PMID 11238912 DOI: 10.1128/Mcb.21.5.1747-1758.2001  0.391
2001 Steppan CM, Brown EJ, Wright CM, Bhat S, Banerjee RR, Dai CY, Enders GH, Silberg DG, Wen X, Wu GD, Lazar MA. A family of tissue-specific resistin-like molecules. Proceedings of the National Academy of Sciences of the United States of America. 98: 502-6. PMID 11209052 DOI: 10.1073/Pnas.98.2.502  0.57
2001 Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA. The hormone resistin links obesity to diabetes. Nature. 409: 307-12. PMID 11201732 DOI: 10.1038/35053000  0.561
2001 Lazar MA. Progress in cardiovascular biology: PPAR for the course Nature Medicine. 7: 23-24. PMID 11135607 DOI: 10.1038/83301  0.394
2001 Zhang J, Hug BA, Huang EY, Chen CW, Gelmetti V, Maccarana M, Minucci S, Pelicci PG, Lazar MA. Oligomerization of ETO is obligatory for corepressor interaction. Molecular and Cellular Biology. 21: 156-63. PMID 11113190 DOI: 10.1128/Mcb.21.1.156-163.2001  0.355
2000 Shang Y, Hu X, DiRenzo J, Lazar MA, Brown M. Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription Cell. 103: 843-852. PMID 11136970 DOI: 10.1016/S0092-8674(00)00188-4  0.402
2000 Rangwala SM, Lazar MA. Transcriptional control of adipogenesis Annual Review of Nutrition. 20: 535-559. PMID 10940345 DOI: 10.1146/Annurev.Nutr.20.1.535  0.466
2000 Minucci S, Maccarana M, Cioce M, De Luca P, Gelmetti V, Segalla S, Di Croce L, Giavara S, Matteucci C, Gobbi A, Bianchini A, Colombo E, Schiavoni I, Badaracco G, Hu X, ... Lazar MA, et al. Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation. Molecular Cell. 5: 811-20. PMID 10882117 DOI: 10.1016/S1097-2765(00)80321-4  0.414
2000 Zhang J, Lazar MA. The mechanism of action of thyroid hormones Annual Review of Physiology. 62: 439-466. PMID 10845098 DOI: 10.1146/Annurev.Physiol.62.1.439  0.401
2000 Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R. A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. Genes & Development. 14: 1048-57. PMID 10809664  0.712
2000 Hastings ML, Ingle HA, Lazar MA, Munroe SH. Post-transcriptional regulation of thyroid hormone receptor expression by cis-acting sequences and a naturally occurring antisense RNA Journal of Biological Chemistry. 275: 11507-11513. PMID 10753970 DOI: 10.1074/Jbc.275.15.11507  0.431
2000 Rachez C, Gamble M, Chang CPB, Atkins GB, Lazar MA, Freedman LP. The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes Molecular and Cellular Biology. 20: 2718-2726. PMID 10733574 DOI: 10.1128/Mcb.20.8.2718-2726.2000  0.441
2000 Gurnell M, Wentworth JM, Agostini M, Adams M, Collingwood TN, Provenzano C, Browne PO, Rajanayagam O, Burris TP, Schwabe JW, Lazar MA, Chatterjee VK. A dominant-negative peroxisome proliferator-activated receptor gamma (PPARgamma) mutant is a constitutive repressor and inhibits PPARgamma-mediated adipogenesis. The Journal of Biological Chemistry. 275: 5754-9. PMID 10681562 DOI: 10.1074/Jbc.275.8.5754  0.426
2000 Hu X, Lazar MA. Transcriptional repression by nuclear hormone receptors Trends in Endocrinology and Metabolism. 11: 6-10. PMID 10652499 DOI: 10.1016/S1043-2760(99)00215-5  0.441
2000 Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA. Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway. Genes & Development. 14: 45-54. PMID 10640275  0.706
2000 Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R. A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. Genes & Development. 14: 1048-1057. DOI: 10.1101/Gad.14.9.1048  0.732
2000 Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA. Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway Genes & Development. 14: 45-54. DOI: 10.1101/Gad.14.1.45  0.726
1999 Hu X, Lazar MA. The CoRNR motif controls the recruitment of compressors by nuclear hormone receptors Nature. 402: 93-96. PMID 10573424 DOI: 10.1038/47069  0.396
1999 Zhu Y, Qi C, Jain S, Le Beau MM, Espinosa R, Atkins GB, Lazar MA, Yeldandi AV, Rao MS, Reddy JK. Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 96: 10848-53. PMID 10485914 DOI: 10.1073/Pnas.96.19.10848  0.339
1999 Atkins GB, Hu X, Guenther MG, Rachez C, Freedman LP, Lazar MA. Coactivators for the orphan nuclear receptor RORalpha. Molecular Endocrinology (Baltimore, Md.). 13: 1550-7. PMID 10478845 DOI: 10.1210/Mend.13.9.0343  0.721
1999 Zhang J, Hu X, Lazar MA. A novel role for helix 12 of retinoid X receptor in regulating repression Molecular and Cellular Biology. 19: 6448-6457. PMID 10454590 DOI: 10.1128/Mcb.19.9.6448  0.451
1999 Su CG, Wen X, Bailey ST, Jiang W, Rangwala SM, Keilbaugh SA, Flanigan A, Murthy S, Lazar MA, Wu GD. A novel therapy for colitis utilizing PPAR-γ ligands to inhibit the epithelial inflammatory response Journal of Clinical Investigation. 104: 383-389. PMID 10449430 DOI: 10.1172/Jci7145  0.388
1999 Shao D, Lazar MA. Modulating nuclear receptor function: May the phos be with you Journal of Clinical Investigation. 103: 1617-1618. PMID 10377165 DOI: 10.1172/Jci7421  0.435
1999 Auwerx J, Baulieu E, Beato M, Becker-Andre M, Burbach PH, Camerino G, Chambon P, Cooney A, Dejean A, Dreyer C, Evans RM, Gannon F, Giguere V, Gronemeyer H, Gustafsson JA, ... ... Lazar MA, et al. A unified nomenclature system for the nuclear receptor superfamily Cell. 97: 161-163. PMID 10219237 DOI: 10.1016/S0092-8674(00)80726-6  0.342
1999 Lazar MA. PPARy in Adipocyte Differentiation Journal of Animal Science. 77: 16-22. DOI: 10.2527/1999.77Suppl_316X  0.402
1999 Reginato MJ, Lazar MA. Mechanisms by which thiazolidinediones enhance insulin action Trends in Endocrinology and Metabolism. 10: 9-13. DOI: 10.1016/S1043-2760(98)00110-6  0.678
1998 Shao D, Rangwala SM, Bailey ST, Krakow SL, Reginato MJ, Lazar MA. Interdomain communication regulating ligand binding by PPAR-γ Nature. 396: 377-380. PMID 9845075 DOI: 10.1038/24634  0.705
1998 Marx N, Schönbeck U, Lazar MA, Libby P, Plutzky J. Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells Circulation Research. 83: 1097-1103. PMID 9831704 DOI: 10.1161/01.Res.83.11.1097  0.337
1998 Reginato MJ, Bailey ST, Krakow SL, Minami C, Ishii S, Tanaka H, Lazar MA. A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor γ-activating properties Journal of Biological Chemistry. 273: 32679-32684. PMID 9830009 DOI: 10.1074/Jbc.273.49.32679  0.705
1998 Gelmetti V, Zhang J, Fanelli M, Minucci S, Pelicci PG, Lazar MA. Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO Molecular and Cellular Biology. 18: 7185-7191. PMID 9819405 DOI: 10.1128/Mcb.18.12.7185  0.412
1998 Zhao Q, Khorasanizadeh S, Miyoshi Y, Lazar MA, Rastinejad F. Structural elements of an orphan nuclear receptor-DNA complex. Molecular Cell. 1: 849-61. PMID 9660968 DOI: 10.1016/S1097-2765(00)80084-2  0.368
1998 Zhang J, Guenther MG, Carthew RW, Lazar MA. Proteasomal regulation of nuclear receptor corepressor-mediated repression. Genes & Development. 12: 1775-80. PMID 9637679 DOI: 10.1101/Gad.12.12.1775  0.756
1998 Grignani F, De Matteis S, Nervi C, Tomassoni L, Gelmetti V, Cioce M, Fanelli M, Ruthardt M, Ferrara FF, Zamir I, Seiser C, Grignani F, Lazar MA, Minucci S, Pelicci PG. Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia. Nature. 391: 815-8. PMID 9486655 DOI: 10.1038/35901  0.369
1998 DuBois RN, Gupta R, Brockman J, Reddy BS, Krakow SL, Lazar MA. The nuclear eicosanoid receptor, PPARγ, is aberrantly expressed in colonic cancers Carcinogenesis. 19: 49-53. PMID 9472692 DOI: 10.1093/Carcin/19.1.49  0.361
1998 Reginato MJ, Krakow SL, Bailey ST, Lazar MA. Prostaglandins promote and block adipogenesis through opposing effects on peroxisome proliferator-activated receptor γ Journal of Biological Chemistry. 273: 1855-1858. PMID 9442016 DOI: 10.1074/Jbc.273.4.1855  0.708
1998 Davis KD, Lazar MA. Chapter 13 Molecular mechanisms of thyroid hormone action Principles of Medical Biology. 10: 321-337. DOI: 10.1016/S1569-2582(97)80040-2  0.306
1997 Zamir I, Dawson J, Lavinsky RM, Glass CK, Rosenfeld MG, Lazar MA. Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex. Proceedings of the National Academy of Sciences of the United States of America. 94: 14400-5. PMID 9405624 DOI: 10.1073/Pnas.94.26.14400  0.442
1997 Adams M, Montague CT, Prins JB, Holder JC, Smith SA, Sanders L, Digby JE, Sewter CP, Lazar MA, Chatterjee VK, O'Rahilly S. Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation. The Journal of Clinical Investigation. 100: 3149-53. PMID 9399962 DOI: 10.1172/Jci119870  0.42
1997 Zhang J, Zamir I, Lazar MA. Differential recognition of liganded and unliganded thyroid hormone receptor by retinoid X receptor regulates transcriptional repression Molecular and Cellular Biology. 17: 6887-6897. PMID 9372920 DOI: 10.1128/Mcb.17.12.6887  0.403
1997 Harding HP, Atkins GB, Jaffe AB, Seo WJ, Lazar MA. Transcriptional activation and repression by RORα, an orphan nuclear receptor required for cerebellar development Molecular Endocrinology. 11: 1737-1746. PMID 9328355 DOI: 10.1210/MEND.11.11.0002  0.35
1997 Michael LF, Lazar MA, Mendelson CR. Peroxisome proliferator-activated receptor γ1 expression is induced during cyclic adenosine monophosphate-stimulated differentiation of alveolar type II pneumonocytes Endocrinology. 138: 3695-3703. PMID 9275054 DOI: 10.1210/Endo.138.9.5373  0.34
1997 Peng Y, Schwarz EJ, Lazar MA, Genin A, Spinner NB, Taub R. Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene Genomics. 43: 278-284. PMID 9268630 DOI: 10.1006/Geno.1997.4821  0.363
1997 Shao D, Lazar MA. Peroxisome proliferator activated receptor γ, CCAAT/enhancer-binding protein α, and cell cycle status regulate the commitment to adipocyte differentiation Journal of Biological Chemistry. 272: 21473-21478. PMID 9261165 DOI: 10.1074/Jbc.272.34.21473  0.378
1997 Zamir I, Zhang J, Lazar MA. Stoichiometric and steric principles governing repression by nuclear hormone receptors Genes and Development. 11: 835-846. PMID 9106656 DOI: 10.1101/Gad.11.7.835  0.431
1997 Schwarz EJ, Reginato MJ, Shao D, Krakow SL, Lazar MA. Retinoic acid blocks adipogenesis by inhibiting C/EBPβ-mediated transcription Molecular and Cellular Biology. 17: 1552-1561. PMID 9032283 DOI: 10.1128/Mcb.17.3.1552  0.666
1997 Cheng X, Reginato MJ, Andrews NC, Lazar MA. The transcriptional integrator CREB-binding protein mediates positive cross talk between nuclear hormone receptors and the hematopoietic bZip protein p45/NF-E2 Molecular and Cellular Biology. 17: 1407-1416. PMID 9032267 DOI: 10.1128/Mcb.17.3.1407  0.679
1997 Adams M, Reginato MJ, Shao D, Lazar MA, Chatterjee VK. Transcriptional activation by peroxisome proliferator-activated receptor γ is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site Journal of Biological Chemistry. 272: 5128-5132. PMID 9030579 DOI: 10.1074/Jbc.272.8.5128  0.7
1996 Reginato MJ, Zhang J, Lazar MA. DNA-independent and DNA-dependent mechanisms regulate the differential heterodimerization of the isoforms of the thyroid hormone receptor with retinoid X receptor Journal of Biological Chemistry. 271: 28199-28205. PMID 8910436 DOI: 10.1074/Jbc.271.45.28199  0.687
1996 Zamir I, Harding HP, Atkins GB, Hörlein A, Glass CK, Rosenfeld MG, Lazar MA. A nuclear hormone receptor corepressor mediates transcriptional silencing by receptors with distinct repression domains. Molecular and Cellular Biology. 16: 5458-65. PMID 8816459 DOI: 10.1128/Mcb.16.10.5458  0.381
1996 Xue JC, Schwarz EJ, Chawla A, Lazar MA. Distinct stages in adipogenesis revealed by retinoid inhibition of differentiation after induction of PPARγ Molecular and Cellular Biology. 16: 1567-1575. PMID 8657131 DOI: 10.1128/Mcb.16.4.1567  0.315
1996 Kallen CB, Lazar MA. Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes Proceedings of the National Academy of Sciences of the United States of America. 93: 5793-5796. PMID 8650171 DOI: 10.1073/Pnas.93.12.5793  0.47
1995 Dimaculangan DD, Chawla A, Boak A, Kagan HM, Lazar MA. Retinoic acid prevents downregulation of ras recision gene/lysyl oxidase early in adipocyte differentiation. Differentiation; Research in Biological Diversity. 58: 47-52. PMID 7867896 DOI: 10.1046/J.1432-0436.1994.5810047.X  0.321
1995 Katz D, Reginato MJ, Lazar MA. Functional regulation of thyroid hormone receptor variant TRα2 by phosphorylation Molecular and Cellular Biology. 15: 2341-2348. PMID 7739517 DOI: 10.1128/Mcb.15.5.2341  0.686
1995 Shulemovich K, Dimaculangan DD, Katz D, Lazar MA. DNA bending by thyroid hormone receptor: influence of half-site spacing and RXR Nucleic Acids Research. 23: 811-818. PMID 7708497 DOI: 10.1093/Nar/23.5.811  0.361
1995 Harding HP, Lazar MA. The monomer-binding orphan receptor Rev-Erb represses transcription as a dimer on a novel direct repeat Molecular and Cellular Biology. 15: 4791-4802. PMID 7651396 DOI: 10.1128/Mcb.15.9.4791  0.41
1995 Yu K, Bayona W, Kallen CB, Harding HP, Ravera CP, McMahon G, Brown M, Lazar MA. Differential activation of peroxisome proliferator-activated receptors by eicosanoids. The Journal of Biological Chemistry. 270: 23975-83. PMID 7592593 DOI: 10.1074/Jbc.270.41.23975  0.394
1994 Chawla A, Lazar MA. Peroxisome proliferator and retinoid signaling pathways co-regulate preadipocyte phenotype and survival Proceedings of the National Academy of Sciences of the United States of America. 91: 1786-1790. PMID 8127882 DOI: 10.1073/Pnas.91.5.1786  0.373
1994 Chawla A, Schwarz EJ, Dimaculangan DD, Lazar MA. Peroxisome proliferator-activated receptor (PPAR) γ: Adipose-predominant expression and induction early in adipocyte differentiation Endocrinology. 135: 798-800. PMID 8033830 DOI: 10.1210/Endo.135.2.8033830  0.437
1994 Gåfvels ME, Paavola LG, Boyd CO, Nolan PM, Wittmaack F, Chawla A, Lazar MA, Bucan M, Angelin BO, Strauss JF. Cloning of a complementary deoxyribonucleic acid encoding the murine homolog of the very low density lipoprotein/apolipoprotein-E receptor: expression pattern and assignment of the gene to mouse chromosome 19. Endocrinology. 135: 387-94. PMID 8013374 DOI: 10.1210/Endo.135.1.8013374  0.376
1994 Dumas B, Harding HP, Choi HS, Lehmann KA, Chung M, Lazar MA, Moore DD. A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb Molecular Endocrinology. 8: 996-1005. PMID 7997240 DOI: 10.1210/Mend.8.8.7997240  0.369
1994 Davis KD, Berrodin TJ, Stelmach JE, Winkler JD, Lazar MA. Endogenous retinoid X receptors can function as hormone receptors in pituitary cells. Molecular and Cellular Biology. 14: 7105-10. PMID 7935425 DOI: 10.1128/Mcb.14.11.7105  0.447
1993 Harding HP, Lazar MA. The orphan receptor Rev-ErbAα activates transcription via a novel response element Molecular and Cellular Biology. 13: 3113-3121. PMID 8474464 DOI: 10.1128/mcb.13.5.3113-3121.1993  0.412
1993 Hupart KH, Hodin RA, Lazar MA, Shapiro LE, Chin WW, Surks MI. c-erb-A mRNA correlates with T3-receptor levels in liver and pituitary of tumor rats Thyroid. 3: 55-58. PMID 8388754 DOI: 10.1089/Thy.1993.3.55  0.557
1993 Chawla A, Lazar MA. Induction of Rev-ErbAα, an orphan receptor encoded on the opposite strand of the α-thyroid hormone receptor gene, during adipocyte differentiation Journal of Biological Chemistry. 268: 16265-16269. PMID 8344913  0.315
1993 Lazar MA. Thyroid hormone receptors: Multiple forms, multiple possibilities Endocrine Reviews. 14: 184-193. PMID 8325251 DOI: 10.1210/Edrv-14-2-184  0.316
1992 Berrodin TJ, Marks MS, Ozato K, Linney E, Lazar MA. Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein. Molecular Endocrinology (Baltimore, Md.). 6: 1468-78. PMID 1331778 DOI: 10.1210/Mend.6.9.1331778  0.383
1992 Katz D, Berrodin TJ, Lazar MA. The unique C-termini of the thyroid hormone receptor variant, c-erbAα2, and thyroid hormone receptor α1 mediate different DNA-binding and heterodimerization properties Molecular Endocrinology. 6: 805-814. PMID 1318505 DOI: 10.1210/Mend.6.5.1318505  0.334
1991 Lazar MA, Berrodin TJ, Harding HP. Differential DNA binding by monomeric, homodimeric, and potentially heteromeric forms of the thyroid hormone receptor Molecular and Cellular Biology. 11: 5005-5015. PMID 1922030 DOI: 10.1128/mcb.11.10.5005-5015.1991  0.381
1991 Lazar MA. Steroid and thyroid hormone receptors Endocrinology and Metabolism Clinics of North America. 20: 681-695. PMID 1778173 DOI: 10.1016/S0889-8529(18)30239-1  0.426
1990 Lazar MA, Berrodin TJ. Thyroid hormone receptors form distinct nuclear protein-dependent and independent complexes with a thyroid hormone response element Molecular Endocrinology. 4: 1627-1635. PMID 2280769 DOI: 10.1210/Mend-4-11-1627  0.35
1990 Lazar MA, Chin WW. Nuclear thyroid hormone receptors Journal of Clinical Investigation. 86: 1777-1782. PMID 2254444 DOI: 10.1172/Jci114906  0.533
1990 Hodin RA, Lazar MA, Chin WW. Differential and tissue-specific regulation of the multiple rat c-erbA messenger RNA species by thyroid hormone Journal of Clinical Investigation. 85: 101-105. PMID 2153150 DOI: 10.1172/Jci114398  0.536
1990 Lazar MA, Jones KE, Chin WW. Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone. Dna and Cell Biology. 9: 77-83. PMID 1971514 DOI: 10.1089/Dna.1990.9.77  0.544
1989 Lazar MA, Hodin RA, Chin WW. Human carboxyl-terminal variant of α-type c-erbA inhibits trans-activation by thyroid hormone receptors without binding thyroid hormone Proceedings of the National Academy of Sciences of the United States of America. 86: 7771-7774. PMID 2554288 DOI: 10.1073/Pnas.86.20.7771  0.54
1989 Lazar MA, Hodin RA, Darling DS, Chin WW. A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbAα transcriptional unit Molecular and Cellular Biology. 9: 1128-1136. PMID 2542765 DOI: 10.1128/mcb.9.3.1128-1136.1989  0.533
1989 Hodin RA, Lazar MA, Wintman BI, Darling DS, Koenig RJ, Larsen PR, Moore DD, Chin WW. Identification of a thyroid hormone receptor that is pituitary-specific Science. 244: 76-79. PMID 2539642 DOI: 10.1126/Science.2539642  0.541
1988 Lazar MA, Hodin RA, Darling DS, Chin WW. Identification of a rat c-erbAα-related protein which binds deoxyribonucleic acid but does not bind thyroid hormone Molecular Endocrinology. 2: 893-901. PMID 2903438 DOI: 10.1210/Mend-2-10-893  0.512
1988 Lazar MA, Chin WW. Regulation of two c-erbA messenger ribonucleic acids in rat GH3 cells by thyroid hormone Molecular Endocrinology. 2: 479-484. PMID 2901667 DOI: 10.1210/Mend-2-6-479  0.535
1983 Lazar MA, Raese JD, Barchas JD. Dephosphorylation of purified brain tyrosine hydroxylase by rat striatal extracts. Neurochemistry International. 5: 107-11. PMID 20487930 DOI: 10.1016/0197-0186(83)90016-5  0.484
1982 Lazar MA, Mefford IN, Barchas JD. Tyrosine hydroxylase activation. Comparison of in vitro phosphorylation and in vivo administration of haloperidol Biochemical Pharmacology. 31: 2599-2607. PMID 6128001 DOI: 10.1016/0006-2952(82)90706-7  0.48
1982 Lazar MA, Lockfeld AJ, Truscott RJW, Barchas JD. Tyrosine hydroxylase from bovine striatum: Catalytic properties of the phosphorylated and nonphosphorylated forms of the purified enzyme Journal of Neurochemistry. 39: 409-422. PMID 6123557 DOI: 10.1111/J.1471-4159.1982.Tb03962.X  0.467
1982 Lazar MA, Barchas JD. The possible role of phosphorylation of tyrosine hydroxylase in catecholaminergic neurons Psychopharmacology Bulletin. 18: 157-161.  0.381
1981 Edelman AM, Raese JD, Lazar MA, Barchas JD. Tyrosine hydroxylase: studies on the phosphorylation of a purified preparation of the brain enzyme by the cyclic AMP-dependent protein kinase. The Journal of Pharmacology and Experimental Therapeutics. 216: 647-53. PMID 6110771  0.67
1981 Lazar MA, Truscott RJW, Raese JD, Barchas JD. Thermal denaturation of native striatal tyrosine hydroxylase: Increased thermolability of the phosphorylated form of the enzyme Journal of Neurochemistry. 36: 677-682. PMID 6109765 DOI: 10.1111/J.1471-4159.1981.Tb01641.X  0.473
1978 Edelman AM, Raese JD, Lazar MA, Barchas JD. In vitro phosphorylation of a purified preparation of bovine corpus striatal tyrosine hydroxylase. Communications in Psychopharmacology. 2: 461-5. PMID 34498  0.658
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