Robert M. Krug - Publications

Affiliations: 
Microbiology, Molecular Biology and Biochemistry University of Texas at Austin, Austin, Texas, U.S.A. 
Area:
Microbiology Biology, Virology Biology

147 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Zhao C, Sridharan H, Chen R, Baker DP, Wang S, Krug RM. Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins. Nature Communications. 7: 12754. PMID 27587337 DOI: 10.1038/ncomms12754  1
2016 Ma LC, Guan R, Hamilton K, Aramini JM, Mao L, Wang S, Krug RM, Montelione GT. A Second RNA-Binding Site in the NS1 Protein of Influenza B Virus. Structure (London, England : 1993). PMID 27545620 DOI: 10.1016/j.str.2016.07.001  1
2016 Kuo RL, Li LH, Lin SJ, Li ZH, Chen GW, Chang CK, Wang YR, Tam EH, Gong YN, Krug RM, Shih SR. The role of N-terminus-truncated NS1 proteins of influenza A virus in inhibiting IRF3 activation. Journal of Virology. PMID 26912617 DOI: 10.1128/JVI.02843-15  1
2015 Liu CH, Zhou L, Chen G, Krug RM. Battle between influenza A virus and a newly identified antiviral activity of the PARP-containing ZAPL protein. Proceedings of the National Academy of Sciences of the United States of America. PMID 26504237 DOI: 10.1073/pnas.1509745112  1
2015 Krug RM. Functions of the influenza A virus NS1 protein in antiviral defense. Current Opinion in Virology. 12: 1-6. PMID 25638592 DOI: 10.1016/j.coviro.2015.01.007  1
2014 Krug RM. Influenza: An RNA-synthesizing machine. Nature. 516: 338-9. PMID 25519129 DOI: 10.1038/516338a  1
2014 Krug RM. Viral proteins that bind double-stranded RNA: countermeasures against host antiviral responses. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 34: 464-8. PMID 24905203 DOI: 10.1089/jir.2014.0005  1
2014 Chen G, Liu CH, Zhou L, Krug RM. Cellular DDX21 RNA helicase inhibits influenza A virus replication but is counteracted by the viral NS1 protein. Cell Host & Microbe. 15: 484-93. PMID 24721576 DOI: 10.1016/j.chom.2014.03.002  1
2014 Aramini JM, Hamilton K, Ma LC, Swapna GV, Leonard PG, Ladbury JE, Krug RM, Montelione GT. (19)F NMR reveals multiple conformations at the dimer interface of the nonstructural protein 1 effector domain from influenza A virus. Structure (London, England : 1993). 22: 515-25. PMID 24582435 DOI: 10.1016/j.str.2014.01.010  1
2014 Barman S, You L, Chen R, Codrea V, Kago G, Edupuganti R, Robertus J, Krug RM, Anslyn EV. Exploring naphthyl-carbohydrazides as inhibitors of influenza A viruses European Journal of Medicinal Chemistry. 71: 81-90. PMID 24287556 DOI: 10.1016/j.ejmech.2013.10.063  1
2013 Seo GJ, Kincaid RP, Phanaksri T, Burke JM, Pare JM, Cox JE, Hsiang TY, Krug RM, Sullivan CS. Reciprocal inhibition between intracellular antiviral signaling and the RNAi machinery in mammalian cells. Cell Host & Microbe. 14: 435-45. PMID 24075860 DOI: 10.1016/j.chom.2013.09.002  1
2013 Zhao C, Collins MN, Hsiang TY, Krug RM. Interferon-induced ISG15 pathway: an ongoing virus-host battle. Trends in Microbiology. 21: 181-6. PMID 23414970 DOI: 10.1016/j.tim.2013.01.005  1
2012 Ye Q, Guu TS, Mata DA, Kuo RL, Smith B, Krug RM, Tao YJ. Biochemical and structural evidence in support of a coherent model for the formation of the double-helical influenza A virus ribonucleoprotein. Mbio. 4: e00467-12. PMID 23269829 DOI: 10.1128/mBio.00467-12  1
2012 Malur M, Gale M, Krug RM. LGP2 downregulates interferon production during infection with seasonal human influenza A viruses that activate interferon regulatory factor 3. Journal of Virology. 86: 10733-8. PMID 22837208 DOI: 10.1128/JVI.00510-12  1
2012 Hsiang TY, Zhou L, Krug RM. Roles of the phosphorylation of specific serines and threonines in the NS1 protein of human influenza A viruses. Journal of Virology. 86: 10370-6. PMID 22787231 DOI: 10.1128/JVI.00732-12  1
2012 Marklund JK, Ye Q, Dong J, Tao YJ, Krug RM. Sequence in the influenza A virus nucleoprotein required for viral polymerase binding and RNA synthesis. Journal of Virology. 86: 7292-7. PMID 22532672 DOI: 10.1128/JVI.00014-12  1
2012 Sundquist WI, Krug RM. Assemble, replicate, remodel and evade. Current Opinion in Virology. 2: 111-4. PMID 22482706 DOI: 10.1016/j.coviro.2012.02.008  1
2012 Cho EJ, Xia S, Ma LC, Robertus J, Krug RM, Anslyn EV, Montelione GT, Ellington AD. Identification of influenza virus inhibitors targeting NS1A utilizing fluorescence polarization-based high-throughput assay Journal of Biomolecular Screening. 17: 448-459. PMID 22223052 DOI: 10.1177/1087057111431488  1
2011 Guan R, Ma LC, Leonard PG, Amer BR, Sridharan H, Zhao C, Krug RM, Montelione GT. Structural basis for the sequence-specific recognition of human ISG15 by the NS1 protein of influenza B virus. Proceedings of the National Academy of Sciences of the United States of America. 108: 13468-73. PMID 21808041 DOI: 10.1073/pnas.1107032108  1
2011 Aramini JM, Ma LC, Zhou L, Schauder CM, Hamilton K, Amer BR, Mack TR, Lee HW, Ciccosanti CT, Zhao L, Xiao R, Krug RM, Montelione GT. Dimer interface of the effector domain of non-structural protein 1 from influenza A virus: an interface with multiple functions. The Journal of Biological Chemistry. 286: 26050-60. PMID 21622573 DOI: 10.1074/jbc.M111.248765  1
2011 Spesock A, Malur M, Hossain MJ, Chen LM, Njaa BL, Davis CT, Lipatov AS, York IA, Krug RM, Donis RO. The virulence of 1997 H5N1 influenza viruses in the mouse model is increased by correcting a defect in their NS1 proteins. Journal of Virology. 85: 7048-58. PMID 21593152 DOI: 10.1128/JVI.00417-11  1
2011 Yin C, Aramini JM, Ma LC, Cort JR, Swapna GV, Krug RM, Montelione GT. Backbone and Ile-δ1, Leu, Val methyl 1H, 13C and 15N NMR chemical shift assignments for human interferon-stimulated gene 15 protein. Biomolecular Nmr Assignments. 5: 215-9. PMID 21544738 DOI: 10.1007/s12104-011-9303-8  1
2011 You L, Cho EJ, Leavitt J, Ma LC, Montelione GT, Anslyn EV, Krug RM, Ellington A, Robertus JD. Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 3007-11. PMID 21478016 DOI: 10.1016/j.bmcl.2011.03.042  1
2010 Schauder C, Ma LC, Krug RM, Montelione GT, Guan R. Structure of the iSH2 domain of human phosphatidylinositol 3-kinase p85β subunit reveals conformational plasticity in the interhelical turn region. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1567-71. PMID 21139197 DOI: 10.1107/S1744309110041333  1
2010 Kuo RL, Zhao C, Malur M, Krug RM. Influenza A virus strains that circulate in humans differ in the ability of their NS1 proteins to block the activation of IRF3 and interferon-β transcription. Virology. 408: 146-58. PMID 20934196 DOI: 10.1016/j.virol.2010.09.012  1
2010 Liu H, Golebiewski L, Dow EC, Krug RM, Javier RT, Rice AP. The ESEV PDZ-binding motif of the avian influenza A virus NS1 protein protects infected cells from apoptosis by directly targeting Scribble. Journal of Virology. 84: 11164-74. PMID 20702615 DOI: 10.1128/JVI.01278-10  1
2010 Das K, Aramini JM, Ma LC, Krug RM, Arnold E. Structures of influenza A proteins and insights into antiviral drug targets. Nature Structural & Molecular Biology. 17: 530-8. PMID 20383144 DOI: 10.1038/nsmb.1779  1
2010 Zhao C, Hsiang TY, Kuo RL, Krug RM. ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 2253-8. PMID 20133869 DOI: 10.1073/pnas.0909144107  1
2010 Sridharan H, Zhao C, Krug RM. Species specificity of the NS1 protein of influenza B virus: NS1 binds only human and non-human primate ubiquitin-like ISG15 proteins. The Journal of Biological Chemistry. 285: 7852-6. PMID 20093371 DOI: 10.1074/jbc.C109.095703  1
2009 Krug RM, Aramini JM. Emerging antiviral targets for influenza A virus. Trends in Pharmacological Sciences. 30: 269-77. PMID 19428126 DOI: 10.1016/j.tips.2009.03.002  1
2009 Hsiang TY, Zhao C, Krug RM. Interferon-induced ISG15 conjugation inhibits influenza A virus gene expression and replication in human cells. Journal of Virology. 83: 5971-7. PMID 19357168 DOI: 10.1128/JVI.01667-08  1
2009 Kuo RL, Krug RM. Influenza a virus polymerase is an integral component of the CPSF30-NS1A protein complex in infected cells. Journal of Virology. 83: 1611-6. PMID 19052083 DOI: 10.1128/JVI.01491-08  1
2009 Newcomb LL, Kuo RL, Ye Q, Jiang Y, Tao YJ, Krug RM. Interaction of the influenza a virus nucleocapsid protein with the viral RNA polymerase potentiates unprimed viral RNA replication. Journal of Virology. 83: 29-36. PMID 18945782 DOI: 10.1128/JVI.02293-07  1
2008 Das K, Ma LC, Xiao R, Radvansky B, Aramini J, Zhao L, Marklund J, Kuo RL, Twu KY, Arnold E, Krug RM, Montelione GT. Structural basis for suppression of a host antiviral response by influenza A virus. Proceedings of the National Academy of Sciences of the United States of America. 105: 13093-8. PMID 18725644 DOI: 10.1073/pnas.0805213105  1
2007 Twu KY, Kuo RL, Marklund J, Krug RM. The H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cells. Journal of Virology. 81: 8112-21. PMID 17522219 DOI: 10.1128/JVI.00006-07  1
2007 Yin C, Khan JA, Swapna GV, Ertekin A, Krug RM, Tong L, Montelione GT. Conserved surface features form the double-stranded RNA binding site of non-structural protein 1 (NS1) from influenza A and B viruses. The Journal of Biological Chemistry. 282: 20584-92. PMID 17475623 DOI: 10.1074/jbc.M611619200  1
2007 Melén K, Kinnunen L, Fagerlund R, Ikonen N, Twu KY, Krug RM, Julkunen I. Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes. Journal of Virology. 81: 5995-6006. PMID 17376915 DOI: 10.1128/JVI.01714-06  1
2007 Min JY, Li S, Sen GC, Krug RM. A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis. Virology. 363: 236-43. PMID 17320139 DOI: 10.1016/j.virol.2007.01.038  1
2006 Ye Q, Krug RM, Tao YJ. The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA. Nature. 444: 1078-82. PMID 17151603 DOI: 10.1038/nature05379  1
2006 Sirén J, Imaizumi T, Sarkar D, Pietilä T, Noah DL, Lin R, Hiscott J, Krug RM, Fisher PB, Julkunen I, Matikainen S. Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines. Microbes and Infection / Institut Pasteur. 8: 2013-20. PMID 16797201 DOI: 10.1016/j.micinf.2006.02.028  1
2006 Min JY, Krug RM. The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2'-5' oligo (A) synthetase/RNase L pathway. Proceedings of the National Academy of Sciences of the United States of America. 103: 7100-5. PMID 16627618 DOI: 10.1073/pnas.0602184103  1
2006 Twu KY, Noah DL, Rao P, Kuo RL, Krug RM. The CPSF30 binding site on the NS1A protein of influenza A virus is a potential antiviral target. Journal of Virology. 80: 3957-65. PMID 16571812 DOI: 10.1128/JVI.80.8.3957-3965.2006  1
2006 Krug RM. Virology. Clues to the virulence of H5N1 viruses in humans. Science (New York, N.Y.). 311: 1562-3. PMID 16543447 DOI: 10.1126/science.1125998  1
2006 Li S, Min JY, Krug RM, Sen GC. Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA. Virology. 349: 13-21. PMID 16466763 DOI: 10.1016/j.virol.2006.01.005  1
2006 Dastur A, Beaudenon S, Kelley M, Krug RM, Huibregtse JM. Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells. The Journal of Biological Chemistry. 281: 4334-8. PMID 16407192 DOI: 10.1074/jbc.M512830200  1
2005 Noah DL, Krug RM. Influenza virus virulence and its molecular determinants. Advances in Virus Research. 65: 121-45. PMID 16387195 DOI: 10.1016/S0065-3527(05)65004-X  1
2005 Krug RM, Zhao C, Beaudenon S. Properties of the ISG15 E1 enzyme UbE1L. Methods in Enzymology. 398: 32-40. PMID 16275317 DOI: 10.1016/S0076-6879(05)98004-X  1
2005 Zhao C, Denison C, Huibregtse JM, Gygi S, Krug RM. Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. Proceedings of the National Academy of Sciences of the United States of America. 102: 10200-5. PMID 16009940 DOI: 10.1073/pnas.0504754102  1
2004 Zhao C, Beaudenon SL, Kelley ML, Waddell MB, Yuan W, Schulman BA, Huibregtse JM, Krug RM. The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein. Proceedings of the National Academy of Sciences of the United States of America. 101: 7578-82. PMID 15131269 DOI: 10.1073/pnas.0402528101  1
2004 Chien CY, Xu Y, Xiao R, Aramini JM, Sahasrabudhe PV, Krug RM, Montelione GT. Biophysical characterization of the complex between double-stranded RNA and the N-terminal domain of the NS1 protein from influenza A virus: evidence for a novel RNA-binding mode. Biochemistry. 43: 1950-62. PMID 14967035 DOI: 10.1021/bi030176o  1
2003 Krug RM, Yuan W, Noah DL, Latham AG. Intracellular warfare between human influenza viruses and human cells: the roles of the viral NS1 protein. Virology. 309: 181-9. PMID 12758165 DOI: 10.1016/S0042-6822(03)00119-3  1
2003 Noah DL, Twu KY, Krug RM. Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3' end processing of cellular pre-mRNAS. Virology. 307: 386-95. PMID 12667806 DOI: 10.1016/S0042-6822(02)00127-7  1
2003 Krug RM. The potential use of influenza virus as an agent for bioterrorism. Antiviral Research. 57: 147-50. PMID 12615310 DOI: 10.1016/S0166-3542(02)00207-3  1
2003 Rao P, Yuan W, Krug RM. Crucial role of CA cleavage sites in the cap-snatching mechanism for initiating viral mRNA synthesis. The Embo Journal. 22: 1188-98. PMID 12606583 DOI: 10.1093/emboj/cdg109  1
2002 Yuan W, Aramini JM, Montelione GT, Krug RM. Structural basis for ubiquitin-like ISG 15 protein binding to the NS1 protein of influenza B virus: a protein-protein interaction function that is not shared by the corresponding N-terminal domain of the NS1 protein of influenza A virus. Virology. 304: 291-301. PMID 12504570 DOI: 10.1006/viro.2002.1663  1
2002 Kim MJ, Latham AG, Krug RM. Human influenza viruses activate an interferon-independent transcription of cellular antiviral genes: outcome with influenza A virus is unique. Proceedings of the National Academy of Sciences of the United States of America. 99: 10096-101. PMID 12114540 DOI: 10.1073/pnas.152327499  1
2001 Schneider R, Agol VI, Andino R, Bayard F, Cavener DR, Chappell SA, Chen JJ, Darlix JL, Dasgupta A, Donzé O, Duncan R, Elroy-Stein O, Farabaugh PJ, Filipowicz W, Gale M, ... ... Krug RM, et al. New ways of initiating translation in eukaryotes. Molecular and Cellular Biology. 21: 8238-46. PMID 11710333 DOI: 10.1128/MCB.21.23.8238-8246.2001  1
2001 Cassetti MC, Noah DL, Montelione GT, Krug RM. Efficient translation of mRNAs in influenza A virus-infected cells is independent of the viral 5′ untranslated region Virology. 289: 180-185. PMID 11689040 DOI: 10.1006/viro.2001.1149  1
2001 Li Y, Chen ZY, Wang W, Baker CC, Krug RM. The mechanism and regulation of deadenylation: Identification and characterization of Xenopus PARN Rna. 7: 875-886. PMID 11424938 DOI: 10.1017/S1355838201010020  1
2001 Li ML, Rao P, Krug RM. The active sites of the influenza cap-dependent endonuclease are on different polymerase subunits. The Embo Journal. 20: 2078-86. PMID 11296240 DOI: 10.1093/emboj/20.8.2078  1
2001 Yuan W, Krug RM. Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein. The Embo Journal. 20: 362-71. PMID 11157743 DOI: 10.1093/emboj/20.3.362  1
2000 Chen Z, Krug RM. Selective nuclear export of viral mRNAs in influenza-virus-infected cells Trends in Microbiology. 8: 376-383. PMID 10920397 DOI: 10.1016/S0966-842X(00)01794-7  1
1999 Chen Z, Li Y, Krug RM. Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery Embo Journal. 18: 2273-2283. PMID 10205180  1
1999 Wang W, Riedel K, Lynch P, Chien CY, Montelione GT, Krug RM. RNA binding by the novel helical domain of the influenza virus NS1 protein requires its dimer structure and a small number of specific basic amino acids Rna. 5: 195-205. PMID 10024172 DOI: 10.1017/S1355838299981621  1
1998 Li ML, Ramirez BC, Krug RM. RNA-dependent activation of primer RNA production by influenza virus polymerase: Different regions of the same protein subunit constitute the two required RNA-binding sites Embo Journal. 17: 5844-5852. PMID 9755184 DOI: 10.1093/emboj/17.19.5844  1
1998 Nemeroff ME, Barabino SML, Li Y, Keller W, Krug RM. Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3′ end formation of cellular pre-mRNAs Molecular Cell. 1: 991-1000. PMID 9651582  1
1998 Li Y, Yamakita Y, Krug RM. Regulation of a nuclear export signal by an adjacent inhibitory sequence: The effector domain of the influenza virus NS1 protein Proceedings of the National Academy of Sciences of the United States of America. 95: 4864-4869. PMID 9560194 DOI: 10.1073/pnas.95.9.4864  1
1998 Chen Z, Li Y, Krug RM. Chimeras containing influenza NS1 and HIV-1 Rev protein sequences: mechanism of their inhibition of nuclear export of Rev protein-RNA complexes. Virology. 241: 234-50. PMID 9499798 DOI: 10.1006/viro.1997.8949  1
1998 Wang W, Krug RM. U6atac snRNA, the highly divergent counterpart of U6 snRNA, is the specific target that mediates inhibition of AT-AC splicing by the influenza virus NS1 protein Rna. 4: 55-64. PMID 9436908  1
1998 Schultz-Cherry S, Krug RM, Hinshaw VS. Induction of apoptosis by influenza virus Seminars in Virology. 8: 491-495. DOI: 10.1006/smvy.1998.0153  1
1997 Liu J, Lynch PA, Chien CY, Montelione GT, Krug RM, Berman HM. Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein. Nature Structural Biology. 4: 896-9. PMID 9360602 DOI: 10.1038/nsb1197-896  1
1997 Chien CY, Tejero R, Huang Y, Zimmerman DE, Rios CB, Krug RM, Montelione GT. A novel RNA-binding motif in influenza A virus non-structural protein 1 Nature Structural Biology. 4: 891-895. PMID 9360601 DOI: 10.1038/nsb1197-891  1
1996 Shih SR, Krug RM. Surprising function of the three influenza viral polymerase proteins: Selective protection of viral mRNAs against the cap-snatching reaction catalyzed by the same polymerase proteins Virology. 226: 430-435. PMID 8955065 DOI: 10.1006/viro.1996.0673  1
1996 Shih SR, Krug RM. Novel exploitation of a nuclear function by influenza virus: The cellular SF2/ASF splicing factor controls the amount of the essential viral M2 ion channel protein in infected cells Embo Journal. 15: 5415-5427. PMID 8895585  1
1996 Wang W, Krug RM. The RNA-binding and effector domains of the viral NS1 protein are conserved to different extents among influenza A and B viruses Virology. 223: 41-50. PMID 8806538 DOI: 10.1006/viro.1996.0453  1
1996 Qian XY, Chen ZY, Zhang J, Rabson AB, Krug RM. New approach for inhibiting REV function and HIV-1 production using the influenza virus NS1 protein Proceedings of the National Academy of Sciences of the United States of America. 93: 8873-8877. PMID 8799120 DOI: 10.1073/pnas.93.17.8873  1
1995 Qian XY, Chien CYA, Lu Y, Montelione GT, Krug RM. An amino-terminal polypeptide fragment of the influenza virus NS1 protein possesses specific RNA-binding activity and largely helical backbone structure Rna. 1: 948-956. PMID 8548659  1
1995 LU Y, WAMBACH M, KATZE MG, KRUG RM. Binding of the Influenza Virus NS1 Protein to Double-Stranded RNA Inhibits the Activation of the Protein Kinase That Phosphorylates the eIF-2 Translation Initiation Factor Virology. 214: 222-228. PMID 8525619 DOI: 10.1006/viro.1995.9937  1
1995 Nemeroff ME, Qian XY, Krug RM. The Influenza Virus NS1 Protein Forms Multimers in Vitro and in Vivo Virology. 212: 422-428. PMID 7571411 DOI: 10.1006/viro.1995.1499  1
1995 Shih SR, Nemeroff ME, Krug RM. The choice of alternative 5′ splice sites in influenza virus M1 mRNA is regulated by the viral polymerase complex Proceedings of the National Academy of Sciences of the United States of America. 92: 6324-6328. PMID 7541537  1
1995 Qiu Y, Nemeroff M, Krug RM. The influenza virus NS1 protein binds to a specific region in human U6 snRNA and inhibits U6-U2 and U6-U4 snRNA interactions during splicing Rna. 1: 304-316. PMID 7489502  1
1994 Qian XY, Alonso-Caplen F, Krug RM. Two functional domains of the influenza virus NS1 protein are required for regulation of nuclear export of mRNA Journal of Virology. 68: 2433-2441. PMID 8139028  1
1994 Lu Y, Qian XY, Krug RM. The influenza virus NS1 protein: A novel inhibitor of pre-mRNA splicing Genes and Development. 8: 1817-1828. PMID 7958859  1
1994 Qiu Y, Krug RM. The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A) Journal of Virology. 68: 2425-2432. PMID 7908060  1
1993 Krug RM. The regulation of export of mRNA from nucleus to cytoplasm Current Opinion in Cell Biology. 5: 944-949. PMID 8129947 DOI: 10.1016/0955-0674(93)90074-Z  1
1992 Nemeroff ME, Utans U, Kramer A, Krug RM. Identification of cis-acting intron and exon regions in influenza virus NS1 mRNA that inhibit splicing and cause the formation of aberrantly sedimenting presplicing complexes Molecular and Cellular Biology. 12: 962-970. PMID 1532050  1
1992 Alonso-Caplen FV, Nemeroff ME, Qiu Y, Krug RM. Nucleocytoplasmic transport: The influenza virus NS1 protein regulates the transport of spliced NS2 mRNA and its precursor NS1 mRNA Genes and Development. 6: 255-267. PMID 1531330  1
1992 Melen K, Ronni T, Broni B, Krug RM, Von Bonsdorff CH, Julkunen I. Interferon-induced Mx proteins form oligomers and contain a putative leucine zipper Journal of Biological Chemistry. 267: 25898-25907. PMID 1281477  1
1991 Alonso-Caplen FV, Krug RM. Regulation of the extent of splicing of influenza virus NS1 mRNA: Role of the rates of splicing and of the nucleocytoplasmic transport of NS1 mRNA Molecular and Cellular Biology. 11: 1092-1098. PMID 1824958  1
1990 Broni B, Julkunen I, Condra JH, Davies ME, Berry MJ, Krug RM. Parental influenza virion nucleocapsids are efficiently transported into the nuclei of murine cells expressing the nuclear interferon-induced Mx protein. Journal of Virology. 64: 6335-40. PMID 2243397  1
1990 Katze MG, Krug RM. Translational control in influenza virus-infected cells Enzyme. 44: 265-277. PMID 2133654  1
1989 Agris CH, Nemeroff ME, Krug RM. A block in mammalian splicing occurring after formation of large complexes containing U1, U2, U4, U5, and U6 small nuclear ribonucleoproteins Molecular and Cellular Biology. 9: 259-267. PMID 2522588  1
1988 Katze MG, Tomita J, Black T, Krug RM, Safer B, Hovanessian A. Influenza virus regulates protein synthesis during infection by repressing autophosphorylation and activity of the cellular 68,000-M(r) protein kinase Journal of Virology. 62: 3710-3717. PMID 3418783  1
1988 Alonso-Caplen FV, Katze MG, Krug RM. Efficient transcription, not translation, is dependent on adenovirus tripartite leader sequences at late times of infection Journal of Virology. 62: 1606-1616. PMID 2833610  1
1988 Shapiro GI, Krug RM. Influenza virus RNA replication in vitro: Synthesis of viral template RNAs and virion RNAs in the absence of an added primer Journal of Virology. 62: 2285-2290. PMID 2453679  1
1988 Alonso-Caplen FV, Agris CH, Nemeroff ME, Krug RM. Regulation of splicing of influenza viral NS1 mRNA Virus Research. 11: 26.  1
1987 Shapiro GI, Gurney T, Krug RM. Influenza virus gene expression: Control mechanisms at early and late times of infection and nuclear-cytoplasmic transport of virus-specific RNAs Journal of Virology. 61: 764-773. PMID 3806797  1
1987 Detjen BM, St. Angelo C, Katze MG, Krug RM. The three influenza virus polymerase (P) proteins not associated with viral nucleocapsids in the infected cell are in the form of a complex Journal of Virology. 61: 16-22. PMID 3783823  1
1987 St. Angelo C, Smith GE, Summers MD, Krug RM. Two of the three influenza viral polymerase proteins expressed by using baculovirus vectors form a complex in insect cells Journal of Virology. 61: 361-365. PMID 3543398  1
1987 Krug RM, St. Angelo C, Broni B, Shapiro G. Transcription and replication of influenza virion RNA in the nucleus of infected cells Cold Spring Harbor Symposia On Quantitative Biology. 52: 353-358. PMID 3454264  1
1986 Katze MG, Detjen BM, Safer B, Krug RM. Translational control by influenza virus: Suppression of the kinase that phosphorylates the alpha subunit of initiation factor eIF-2 and selective translation of influenza viral mRNAs Molecular and Cellular Biology. 6: 1741-1750. PMID 3785177  1
1986 Beaton AR, Krug RM. Transcription antitermination during influenza viral template RNA synthesis requires the nucleocapsid protein and the absence of a 5' capped end Proceedings of the National Academy of Sciences of the United States of America. 83: 6282-6286. PMID 3462695  1
1986 Plotch SJ, Krug RM. In vitro splicing of influenza viral NS1 mRNA and NS1-β-globin chimeras: Possible mechanisms for the control of viral mRNA splicing Proceedings of the National Academy of Sciences of the United States of America. 83: 5444-5448. PMID 3461442  1
1986 Katze MG, DeCorato D, Krug RM. Cellular mRNA translation is blocked at both initiation and elongation after infection by influenza virus or adenovirus Journal of Virology. 60: 1027-1039. PMID 3023655  1
1985 Braam-Markson J, Jaudon C, Krug RM. Expression of a functional influenza viral cap-recognizing protein by using a bovine papilloma virus vector Proceedings of the National Academy of Sciences of the United States of America. 82: 4326-4330. PMID 2989815  1
1985 Krug RM, Shaw M, Broni B, Shapiro G, Haller O. Inhibition of influenza viral mRNA synthesis in cells expressing the interferon-induced Mx gene product Journal of Virology. 56: 201-206. PMID 2411949  1
1985 Krug RM. The role of RNA priming in viral and trypanosomal mRNA synthesis Cell. 41: 651-652. PMID 2408758  1
1984 Beaton AR, Krug RM. Synthesis of the templates for influenza virion RNA replication in vitro Proceedings of the National Academy of Sciences of the United States of America. 81: 4682-4686. PMID 6589616  1
1984 Katze MG, Chen YT, Krug RM. Nuclear-cytoplasmic transport and VAI RNA-independent translation of influenza viral messenger RNAs in late adenovirus-infected cells Cell. 37: 483-490. PMID 6327069 DOI: 10.1016/0092-8674(84)90378-7  1
1984 Katze MG, Krug RM. Metabolism and expression of RNA polymerase II transcripts in influenza virus-infected cells Molecular and Cellular Biology. 4: 2198-2206. PMID 6095046  1
1984 Katze MG, Cheng YT, Krug RM. Translational control: Influenza viral mRNA translation in late adenorirus-infected cells is VAI RNA-independent Federation Proceedings. 43.  1
1983 Ulmanen I, Broni B, Krug RM. Influenza virus temperature-sensitive Cap (m7GpppNm)-dependent endonuclease Journal of Virology. 45: 27-35. PMID 6823015  1
1983 Braam J, Ulmanen I, Krug RM. Molecular model of a eucaryotic transcription complex: Functions and movements of influenza P proteins during capped RNA-primed transcription Cell. 34: 611-618. PMID 6616622 DOI: 10.1016/0092-8674(83)90393-8  1
1982 Heggeness MH, Smith PR, Ulmanen I, Krug RM, Choppin PW. Studies on the helical nucleocapsid of influenza virus. Virology. 118: 466-70. PMID 7090187 DOI: 10.1016/0042-6822(82)90367-1  1
1981 Herz C, Stavnezer E, Krug RM, Gurney T. Influenza virus, an RNA virus, synthesizes its messenger RNA in the nucleus of infected cells Cell. 26: 391-400. PMID 7326745 DOI: 10.1016/0092-8674(81)90208-7  1
1981 Beaton AR, Krug RM. Selected host cell capped RNA fragments prime influenza viral RNA transcription in vivo Nucleic Acids Research. 9: 4423-4436. PMID 7301581 DOI: 10.1093/nar/9.17.4423  1
1981 Ulmanen I, Broni BA, Krug RM. Role of two of the influenza virus core P proteins in recognizing cap 1 structures (m7GpppNm) on RNAs and in initiating viral RNA transcription Proceedings of the National Academy of Sciences of the United States of America. 78: 7355-7359. PMID 6950380  1
1981 Krug RM. Priming of influenza viral RNA transcription by capped heterologous RNAs Current Topics in Microbiology and Immunology. 93: 125-149. PMID 6269803  1
1981 Plotch SJ, Bouloy M, Ulmanen I, Krug RM. A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription Cell. 23: 847-858. PMID 6261960 DOI: 10.1016/0092-8674(81)90449-9  1
1981 Krug RM, Bouloy M, Plotch SJ. The 5′ ends of influenza viral messenger RNAs are donated by capped cellular RNAs Trends in Biochemical Sciences. 6: 7-10. DOI: 10.1016/0968-0004(81)90004-9  1
1980 Robertson HD, Dickson E, Plotch SJ, Krug RM. Identification of the RNA region transferred from a representative primer, β-globin mRNA, to influenza mRNA during in vitro transcription Nucleic Acids Research. 8: 925-942. PMID 7443546 DOI: 10.1093/nar/8.5.925  1
1980 Krug RM, Broni BA, LaFiandra AJ, Morgan MA, Shatkin AJ. Priming and inhibitory activities of RNAs for the influenza viral transcriptase do not require base pairing with the virion template RNA. Proceedings of the National Academy of Sciences of the United States of America. 77: 5874-8. PMID 6934519 DOI: 10.1073/pnas.77.10.5874  1
1980 Bouloy M, Plotch SJ, Krug RM. Both the 7-methyl and the 2'-O-methyl groups in the cap of mRNA strongly influence its ability to act as primer for influenza virus RNA transcription Proceedings of the National Academy of Sciences of the United States of America. 77: 3952-3956. PMID 6933444  1
1980 Krug RM, Bouloy M, Plotch SJ. RNA primers and the role of host nuclear RNA polymerase II in influenza viral RNA transcription Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 288: 359-370. PMID 6103553  1
1979 Bouloy M, Morgan MA, Shatkin AJ, Krug RM. Cap and internal nucleotides of reovirus mRNA primers are incorporated into influenza viral complementary RNA during transcription in vitro. Journal of Virology. 32: 895-904. PMID 513205  1
1979 Krug RM, Broni BA, Bouloy M. Are the 5′ ends of influenza viral mrnas synthesized in vivo donated by host mRNAs? Cell. 18: 329-334. PMID 498272 DOI: 10.1016/0092-8674(79)90052-7  1
1979 Mark GE, Taylor JM, Broni B, Krug RM. Nuclear accumulation of influenza viral RNA transcripts and the effects of cycloheximide, actinomycin D, and α-amanitin Journal of Virology. 29: 744-752. PMID 430609  1
1979 Plotch SJ, Bouloy M, Krug RM. Transfer of 5'-terminal cap of globin mRNA to influenza viral complementary RNA during transcription in vitro Proceedings of the National Academy of Sciences of the United States of America. 76: 1618-1622. PMID 287003  1
1978 Plotch SJ, Tomasz J, Krug RM. Absence of detectable capping and methylating enzymes in influenza virions Journal of Virology. 28: 75-83. PMID 702657  1
1978 Plotch SJ, Krug RM. Segments of influenza virus complementary RNA synthesized in vitro Journal of Virology. 25: 579-586. PMID 625084  1
1978 Bouloy M, Plotch SJ, Krug RM. Globin mRNAs are primers for the transcription of influenza viral RNA in vitro Proceedings of the National Academy of Sciences of the United States of America. 75: 4886-4890. PMID 283399  1
1978 Tomasz J, Simoncsits A, Kajtár M, Krug RM, Shatkin AJ. Chemical synthesis of 5'-pyrophosphate and triphosphate derivatives of 3'-5' ApA, ApG, GpA and GpG. CD study of the effect of 5'-phosphate groups on the conformation of 3'-5' GpG. Nucleic Acids Research. 5: 2945-57. PMID 211490 DOI: 10.1093/nar/5.8.2945  1
1977 Etkind PR, Buchhagen DL, Herz C, Broni BB, Krug RM. The segments of influenza viral mRNA Journal of Virology. 22: 346-352. PMID 864831  1
1977 Taylor JM, Illmensee R, Litwin S, Herring L, Broni B, Krug RM. Use of specific radioactive probes to study transcription and replication of the influenza virus genome Journal of Virology. 21: 530-540. PMID 833937  1
1977 Plotch SJ, Krug RM. Influenza virion transcriptase: Synthesis in vitro of large, polyadenylic acid containing complementary RNA Journal of Virology. 21: 24-34. PMID 833924  1
1976 Krug RM, Morgan MA, Shatkin AJ. Influenza viral mRNA contains internal N6 methyladenosine and 5' terminal 7 methylguanosine in cap structures Journal of Virology. 20: 45-53. PMID 1086370  1
1975 Etkind PR, Krug RM. Purification of influenza viral complementary RNA: its genetic content and activity in wheat germ cell free extracts Journal of Virology. 16: 1464-1475. PMID 1202245  1
1975 Krug RM, Soeiro R. Studies on the intranuclear localization of influenza virus-specific proteins. Virology. 64: 378-87. PMID 1169845 DOI: 10.1016/0042-6822(75)90114-2  1
1975 Krug RM, Ueda M, Palese P. Temperature sensitive mutants of influenza WSN virus defective in virus specific RNA synthesis Journal of Virology. 16: 790-796. PMID 1165595  1
1974 Etkind PR, Krug RM. Influenza viral messenger RNA Virology. 62: 38-45. PMID 4473156 DOI: 10.1016/0042-6822(74)90301-8  1
1973 Krug RM, Etkind PR. Cytoplasmic and nuclear virus-specific proteins in influenza virus-infected MDCK cells Virology. 56: 334-348. PMID 4795673 DOI: 10.1016/0042-6822(73)90310-3  1
1972 Krug RM. Cytoplasmic and nucleoplasmic viral RNPs in influenza virus-infected MDCK cells Virology. 50: 103-113. PMID 4673271 DOI: 10.1016/0042-6822(72)90350-9  1
1971 Krug RM. Influenza viral RNPs newly synthesized during the latent period of viral growth in MDCK cells Virology. 44: 125-136. PMID 4999122 DOI: 10.1016/0042-6822(71)90159-0  1
1969 Krug RM, Gomatos PJ. Absence of adenine-rich ribonucleic acid from purified infectious reovirus 3 Journal of Virology. 4: 642-650. PMID 4902632  1
1965 Krug RM, Gomatos PJ, Tamm I. Enzymic synthesis of RNA with reovirus RNA as template. II. Nearest neighbor analysis of the products of the reaction catalyzed by the Escherichia coli RNA polymerase. Journal of Molecular Biology. 12: 872-80. PMID 5323486  1
1964 GOMATOS PJ, KRUG RM, TAMM I. ENZYMIC SYNTHESIS OF RNA WITH REOVIRUS RNA AS TEMPLATE. I. CHARACTERISTICS OF THE REACTION CATALYZED BY THE RNA POLYMERASE FROM ESCHERICHIA COLI. Journal of Molecular Biology. 9: 193-207. PMID 14200382  1
1964 Krug RM, Franklin RM. Studies on the time of synthesis of Mengovirus ribonucleic acid and protein Virology. 22: 48-58.  1
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